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https://www.readbyqxmd.com/read/28181217/hypercoagulability-and-migraine
#1
Gretchen E Tietjen, Stuart A Collins
BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms...
February 9, 2017: Headache
https://www.readbyqxmd.com/read/28121918/intracranial-dermoid-cyst-rupture-related-brain-ischemia-case-report-and-hemodynamic-study
#2
Hang Jin, Zhen-Ni Guo, Yun Luo, Ren Zhao, Ming-Shuo Sun, Yi Yang
RATIONALE: Spontaneous rupture of intracranial dermoid cyst is a rare but serious clinical event that can result in cerebral ischemia. Cerebral vasospasm and vasculitis are considered as potential mechanisms of dermoid cyst rupture-related cerebral ischemia. However, the hemodynamic mechanisms between cerebral ischemia and dermoid cyst rupture are not well known. PATIENT CONCERNS: A 55-year-old, right-handed man was admitted to our hospital with sudden receptive aphasia and right-sided hypoalgesia...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28088807/posterior-versus-anterior-circulation-stroke-in-young-adults-a-comparative-study-of-stroke-aetiologies-and-risk-factors-in-stroke-among-young-fabry-patients-sifap1
#3
Bettina von Sarnowski, Ulf Schminke, Ulrike Grittner, Christian Tanislav, Tobias Böttcher, Michael G Hennerici, Turgut Tatlisumak, Jukka Putaala, Manfred Kaps, Franz Fazekas, Christian Enzinger, Arndt Rolfs, Christof Kessler
BACKGROUND: Although 20-30% of all strokes occur in the posterior circulation, few studies have explored the characteristics of patients with strokes in the posterior compared to the anterior circulation so far. Especially data on young patients is missing. METHODS: In this secondary analysis of data of the prospective multi-centre European sifap1 study that investigated stroke and transient ischemic attack (TIA) patients aged 18-55 years, we compared vascular risk factors, stroke aetiology, presence of white matter hyperintensities (WMH) and cerebral microbleeds (CMB) between patients with ischaemic posterior circulation stroke (PCS) and those having suffered from anterior circulation stroke (ACS) based on cerebral MRI...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28049199/systemic-atherosclerosis-relate-to-brain-arterial-diameters-the-northern-manhattan-study
#4
Jose Gutierrez, Tatjana Rundek, Ken Cheung, Ahmet Bagci, Noam Alperin, Ralph L Sacco, Clinton B Wright, Mitchell S V Elkind, Marco R Di Tullio
BACKGROUND: Phenotypic expressions of arterial disease vary throughout the body and it is not clear to what extent systemic atherosclerosis influences brain arterial remodeling. We aim to test the hypothesis that systemic atherosclerosis is associated with brain arterial diameters. METHODS: Stroke-free participants in the Northern Manhattan Study MRI subcohort in whom carotid ultrasound, transthoracic echocardiogram, and brain MRA (n = 482) were performed were included in this analysis...
January 4, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27987504/-diagnostic-value-of-carotid-atherosclerosis-score-for-ischemic-stroke
#5
T Y Xiao, Y Liu, J L Li, R T Wang, J C DU
OBJECTIVE: To discuss the diagnostic value of carotid atherosclerosis score for ischemic stroke. METHODS: In the study, 151 patients with ischemic stroke were enrolled, who were diagnosed by cranial CT scan or cranial MRI scan, and examined with carotid duplex ultrasound, and 151 healthy check-up cases matched by age and sex were chosen as control group, who were excluded ischemic stroke by cranial CT scan or cranial MRI scan. All the control cases were examined with carotid duplex ultrasound also...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27984560/relationship-between-carotid-stenosis-and-infarct-volume-in-ischemic-stroke-patients
#6
Aybala Neslihan Alagoz, Bilgehan Atılgan Acar, Türkan Acar, Alper Karacan, Bekir Enes Demiryürek
BACKGROUND Stroke is a serious health problem all over the world. Ischemia causes 85% of strokes and 75% of these ischemic strokes occur within the area supplied by the internal carotid artery (ICA). MATERIAL AND METHODS This study included 47 acute stroke patients who were in the large-artery atherosclerosis group according to Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification and who had an infarct in the area supplied by the internal carotid artery. We sought to determine whether there was a significant correlation between the infarct volume of the patients as measured by diffusion-weighted magnetic resonance imaging (DW MRI), their National Institutes of Health Stroke Scale (NIHSS), and degree of carotid stenosis as identified by carotid computed tomography angiography (CTA)...
December 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27960181/stroke-mechanisms
#7
Ka Sing Wong, Louis R Caplan, Jong S Kim
Recent advances in neuroimaging technologies, such as diffusion weighted magnetic resonance imaging (MRI), perfusion weighted computed tomography (CT)/MRI, MR/CT angiography and Doppler ultrasonography allow us to determine the mechanisms of stroke and transient ischemic attack. In addition, high-resolution vessel wall MRI is nowadays increasingly used to understand the stroke mechanism in patients with intracranial atherosclerosis. Artery to artery embolism, hypoperfusion and the combination of the two are the important stroke mechanisms in patients with extracranial atherosclerosis...
2016: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/27843693/treatment-and-imaging-of-intracranial-atherosclerotic-stenosis-current-perspectives-and-future-directions
#8
REVIEW
Ido R van den Wijngaard, Ghislaine Holswilder, Marianne A A van Walderveen, Ale Algra, Marieke J H Wermer, Osama O Zaidat, Jelis Boiten
BACKGROUND AND PURPOSE: Intracranial atherosclerosis is a common cause of stroke worldwide. It results in ischemic stroke due to different mechanisms including artery-to-artery embolism, in situ thrombo-occlusion, occlusion of perforating arteries, and hemodynamic failure. In this review, we present an overview of current treatment and imaging modalities in intracranial atherosclerotic stenosis. METHODS: PubMed was searched for relevant articles in English that evaluated the treatment and imaging of intracranial atherosclerotic stenosis (ICAS)...
November 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27790125/a-case-of-turner-syndrome-with-multiple-embolic-infarcts
#9
Cindy W Yoon, Eungseok Lee, Byung-Nam Yoon, Hee-Kwon Park, Joung-Ho Rha
Only a few cases of Turner syndrome (TS) with ischemic stroke have been reported. Various arteriopathies of the cerebral arteries, including fibromuscular dysplasia, congenital hypoplasia, moyamoya syndrome, and premature atherosclerosis have been assumed to be the cause of ischemic stroke in TS. There has been no case report of a TS patient presenting with an embolic stroke pattern without any cerebral arteriopathy. A 28-year-old woman with TS was referred to our hospital because of abnormal brain magnetic resonance imaging (MRI) findings...
September 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27586679/magnetic-resonance-perfusion-imaging-provides-a-significant-tool-for-the-identification-of-cardioembolic-stroke
#10
Chun-Hsien Lin, Yuan-Hsiung Tsai, Jiann-Der Lee, Hsu-Huei Weng, Jen-Tsung Yang, Leng-Chieh Lin, Ya-Hui Lin, Chih-Ying Wu, Ying-Chih Huang, Huan-Lin Hsu, Meng Lee, Chia-Yu Hsu, Yi-Ting Pan, Yen-Chu Huang
Despite advances in imaging techniques and detailed examinations to determine the etiology of a stroke, the cause still remains undetermined in about one fourth of all ischemic strokes. The aim of this prospective study was to determine whether perfusion magnetic resonance imaging (MRI) can differentiate cardioembolic stroke from large artery atherosclerosis (LAA). We recruited 17 cardioembolic stroke and 22 LAA stroke patients, who were classified according to the Trial of Org 10172 in Acute Stroke Treatment and underwent perfusion MRI within 24 hours after the onset of stroke...
2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27573442/magnetic-resonance-imaging-of-plaque-burden-in-vascular-walls-of-the-middle-cerebral-artery-correlates-with-cerebral-infarction
#11
Fei Li, Qian-Xue Chen, Zhi-Biao Chen, Dao-Feng Tian, Qiang Cai
Intracranial atherosclerosis may be related to the risk of ischemic stroke. High-resolution magnetic resonance imaging (H-R MRI) makes it possible to measure the intracranial atheroma in vivo. The aim of this study was to evaluate the plaque burden of the middle cerebral artery (MCA) using H-R MRI, and to determine its relationship with both cerebral infarction size and plaque burden in the carotid artery (CA). 54 patients with MCA territory infarction were enrolled and HR-MRI was performed within 7 days following stroke onset...
2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27554075/independent-correlation-of-serum-homocysteine-with-cerebral-microbleeds-in-patients-with-acute-ischemic-stroke-due-to-large-artery-atherosclerosis
#12
Bian-Rong Wang, Zhou Ou, Teng Jiang, Ying-Dong Zhang, Hong-Dong Zhao, You-Yong Tian, Jian-Quan Shi, Jun-Shan Zhou
BACKGROUND AND AIM: The severity of cerebral microbleeds (CMBs) affected the prognosis of patients with acute cerebrovascular disease. Considering the impact of CMBs on clinical decision, it is necessary to assess the risk factors of CMBs. We aimed to evaluate the independent risk factors of CMBs in patients with acute ischemic stroke of large-artery atherosclerosis. MATERIALS AND METHODS: 112 patients were enrolled in the study. The baseline information, the results of laboratory examination and cranial MRI were collected...
November 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27540477/recent-advances-in-pathogenesis-assessment-and-treatment-of-atherosclerosis
#13
REVIEW
J David Spence
In recent years, there have been a number of advances in the pathogenesis and treatment of atherosclerosis and in assessing prognosis in carotid atherosclerosis. Risk stratification to improve vascular prevention by identifying patients most likely to benefit from intensive therapy is much improved by measuring carotid plaque burden. In patients with asymptomatic carotid stenosis, a number of modalities can be used to identify the 10-15% who could benefit from endarterectomy or stenting. Transcranial Doppler embolus detection, echolucency and ulceration on 3D ultrasound, intraplaque hemorrhage on magnetic resonance imaging (MRI), and reduced cerebrovascular reserve are useful already; new approaches including plaque texture on ultrasound and imaging of plaque inflammation and early calcification on positron emission tomography/computed tomography (PET/CT) are in development...
2016: F1000Research
https://www.readbyqxmd.com/read/27533937/clinical-usefulness-of-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-in-patients-with-ischemic-stroke
#14
Hyung-Suk Lee, Hye Lim Lee, Ho-Seong Han, Minju Yeo, Ji Seon Kim, Sung-Hyun Lee, Sang-Soo Lee, Dong-Ick Shin
Ankle brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are widely used noninvasive modalities to evaluate atherosclerosis. Recently, evidence has increased supporting the use of ABI and baPWV as markers of cerebrovascular disease. This study sought to examine the relationship between ABI and baPWV with ischemic stroke. This study also aimed to determine which pathogenic mechanism, large artery disease (LAD) or small vessel disease (SVD), is related to ABI or baPWV. Retrospectively, 121 patients with ischemic stroke and 38 subjects with no obvious ischemic stroke history were recruited...
July 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27532106/qualitative-evaluation-of-a-high-resolution-3d-multi-sequence-intracranial-vessel-wall-protocol-at-3-tesla-mri
#15
Nikki Dieleman, Wenjie Yang, Anja G van der Kolk, Jill Abrigo, Ka Lok Lee, Winnie Chiu Wing Chu, Jaco J M Zwanenburg, Jeroen C W Siero, Ka Sing Wong, Jeroen Hendrikse, Fiona Xiang Yan Chen
BACKGROUND AND PURPOSE: Intracranial vessel wall imaging using MRI has great potential as a clinical method for assessing intracranial atherosclerosis. The purpose of the current study was to compare three 3T MRI vessel wall sequences with different contrast weightings (T1w, PD, T2w) and dedicated sagittal orientation perpendicular to the middle cerebral artery, to the reconstructed sagittal image from a transverse 3D T1w volumetric isotropically reconstructed turbo spin-echo acquisition (VIRTA), and provide a clinical recommendation...
2016: PloS One
https://www.readbyqxmd.com/read/27527539/vessel-wall-mri-of-an-inflamed-aneurysm-with-atherosclerosis-in-a-patient-with-ischemic-stroke
#16
Adam de Havenon, Min Park, Scott McNally
No abstract text is available yet for this article.
August 16, 2016: Neurology
https://www.readbyqxmd.com/read/27507861/nonatheroscleotic-isolated-middle-cerebral-artery-disease-may-be-early-manifestation-of-moyamoya-disease
#17
Yeon-Jung Kim, Joo Kyung Lee, Sung-Ho Ahn, Bum Joon Kim, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND AND PURPOSE: Middle cerebral artery steno-occlusive disease (MCAD) is not an uncommon cause of ischemic stroke in young Asians. Aside from atherosclerosis, the pathogenesis of MCAD include various nonatherosclerotic vasculopathies, most of which are yet to be defined. This study investigated the pathogenesis of symptomatic isolated MCAD in young Asian patients using high-resolution magnetic resonance imaging (HR-MRI) and mutation analysis of RNF213. METHODS: Patients aged <60 years with stroke or transient ischemic attack caused by MCAD were prospectively enrolled...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27506779/acute-stroke-with-major-intracranial-vessel-occlusion-characteristics-of-cardioembolism-and-atherosclerosis-related-in-situ-stenosis-occlusion
#18
Nobutaka Horie, Yohei Tateishi, Minoru Morikawa, Yoichi Morofuji, Kentaro Hayashi, Tsuyoshi Izumo, Akira Tsujino, Izumi Nagata, Takayuki Matsuo
Acute ischemic stroke with major intracranial vessel occlusion is commonly due to cardioembolic or atherosclerosis-related in situ stenosis/occlusion, and immediate identification of these subtypes is important to establish the optimal treatment strategy. The aim of this study was to clarify the differences in clinical presentation, radiological findings, neurological temporal courses, and outcomes between these etiologies, which have not been fully evaluated. Consecutive emergency patients with acute ischemic stroke were retrospectively reviewed...
October 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27488980/association-between-aortic-atheroma-and-cerebral-small-vessel-disease-in-patients-with-ischemic-stroke
#19
Tae-Jin Song, Young Dae Kim, Joonsang Yoo, Jinkwon Kim, Hyuk-Jae Chang, Geu Ru Hong, Chi Young Shim, Dongbeom Song, Ji Hoe Heo, Hyo Suk Nam
BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVDs) are related with large artery atherosclerosis. However, the association between aortic atheroma (AA) and cerebral small vessel disease has rarely been reported. This study evaluated the relationship between presence and burden of AAs and those of SVDs in patients with acute ischemic stroke. METHODS: We included 737 consecutive patients who underwent transesophageal echocardiography (TEE) and brain magnetic resonance imaging (MRI) for evaluation of acute stroke...
September 2016: Journal of Stroke
https://www.readbyqxmd.com/read/27488238/mediterranean-diet-score-and-left-ventricular-structure-and-function-the-multi-ethnic-study-of-atherosclerosis
#20
Emily B Levitan, Ali Ahmed, Donna K Arnett, Joseph F Polak, W Gregory Hundley, David A Bluemke, Susan R Heckbert, David R Jacobs, Jennifer A Nettleton
BACKGROUND: Data are limited on the relation between dietary patterns and left ventricular (LV) structure and function. OBJECTIVE: We examined cross-sectional associations of a diet-score assessment of a Mediterranean dietary pattern with LV mass, volume, mass-to-volume ratio, stroke volume, and ejection fraction. DESIGN: We measured LV variables with the use of cardiac MRI in 4497 participants in the Multi-Ethnic Study of Atherosclerosis study who were aged 45-84 y and without clinical cardiovascular disease...
September 2016: American Journal of Clinical Nutrition
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