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atherosclerosis MRI stroke

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https://www.readbyqxmd.com/read/29097437/associations-of-endogenous-estradiol-and-testosterone-levels-with-plaque-composition-and-risk-of-stroke-in-subjects-with-carotid-atherosclerosis
#1
Marija Glisic, Blerim Mujaj, Oscar L Rueda-Ochoa, Eralda Asllanaj, Joop S Laven, Maryam Kavousi, M Kamran Ikram, Meike W Vernooij, M Arfan Ikram, Oscar H Franco, Daniel Bos, Taulant Muka
Rationale: Sex steroids may play a role in plaque composition and in stroke incidence. Objective: To study the associations of endogenous estradiol and testosterone with carotid plaque composition in elderly men and postmenopausal women with carotid atherosclerosis, as well as with risk of stroke in this population. Methods and Results: Data of 1023 postmenopausal women and 1124 men (≥45 years) with carotid atherosclerosis, from prospective population-based Rotterdam Study, were available. At baseline, total estradiol (TE) and total testosterone (TT) were measured...
November 2, 2017: Circulation Research
https://www.readbyqxmd.com/read/29040971/characteristics-and-outcomes-of-vertebrobasilar-artery-dissection-with-accompanied-atherosclerosis
#2
Chun Chien, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Chih-Ping Chung
BACKGROUND: With the popularity of MRI use, vertebrobasilar artery dissection (VBD) has been found more frequently in patients with posterior circulation ischemic stroke (PCS). The relationship between VBD and atherosclerosis is unknown. The present study aimed to prove the hypothesis that PCS with pure VBD (p-VBD) and with VBD and accompanied cervical or cerebral artery atherosclerosis (a-VBD) have distinct manifestations. METHODS: Patients with VBD-related PCS who were prospectively enrolled in the Taipei Veterans General Hospital Stroke Registry between January 1, 2010 and August 31, 2014 were recruited for the present study...
October 17, 2017: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/28974389/high-prevalence-of-small-vessel-disease-long-after-cranial-irradiation
#3
Masatomo Miura, Makoto Nakajima, Akiko Fujimoto, Yasuyuki Kaku, Takayuki Kawano, Masaki Watanabe, Jun-Ichi Kuratsu, Yukio Ando
Accelerated atherosclerosis of intra- or extracranial large arteries is a major cause of radiation-induced strokes. Recent development of MRI techniques has enabled detection of another important vasculopathy: microinfarcts or microbleeds after cranial irradiation. The purpose of this study was to investigate the incidence and characteristics of small vessel disease after cranial irradiation. MR images and clinical records of 102 outpatients who had undergone cranial irradiation to brain tumors were retrospectively reviewed...
December 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28959486/chinese-atherosclerosis-risk-evaluation-care-ii-study-a-novel-cross-sectional-multicentre-study-of-the-prevalence-of-high-risk-atherosclerotic-carotid-plaque-in-chinese-patients-with-ischaemic-cerebrovascular-events-design-and-rationale
#4
Xihai Zhao, Rui Li, Daniel S Hippe, Thomas S Hatsukami, Chun Yuan
BACKGROUND: Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke. However, the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population. OBJECTIVES: The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack (TIA)...
March 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28950911/assessment-of-intracranial-vessels-in-association-with-carotid-atherosclerosis-and-brain-vascular-lesions-in-rheumatoid-arthritis
#5
Csaba Oláh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki, Zoltán Szekanecz
BACKGROUND: Stroke has been associated with rheumatoid arthritis (RA). We assessed patients with RA and healthy control subjects by transcranial Doppler (TCD), carotid ultrasonography and brain magnetic resonance imaging (MRI). METHODS: Altogether, 41 female patients with RA undergoing methotrexate (MTX) or biologic treatment and 60 age-matched control subjects underwent TCD assessment of the middle cerebral artery (MCA) and basilar artery. Pulsatility index (PI), resistivity (resistance) index (RI) and circulatory reserve capacity (CRC) were determined at rest (r) and after apnoea (a) and hyperventilation (h)...
September 26, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28942481/high-resolution-vessel-wall-mri-for-the-evaluation-of-intracranial-atherosclerotic-disease
#6
REVIEW
Adam de Havenon, Mahmud Mossa-Basha, Lubdha Shah, Seong-Eun Kim, Min Park, Dennis Parker, J Scott McNally
High-resolution vessel wall MRI (vwMRI) of the intracranial arteries is an emerging diagnostic imaging technique with the goal of evaluating vascular pathology. vwMRI sequences have high spatial resolution and directly image the vessel wall by suppressing blood signal. With vwMRI, it is possible to identify distinct morphologic and enhancement patterns of atherosclerosis that can provide important information about stroke etiology and recurrence risk. We present a review of vwMRI research in relation to intracranial atherosclerosis, with a focus on the relationship between ischemic stroke and atherosclerotic plaque T1 post-contrast enhancement or plaque/vessel wall morphology...
December 2017: Neuroradiology
https://www.readbyqxmd.com/read/28856071/prediction-of-functional-outcome-in-ischemic-stroke-patients-an-observational-study-on-egyptian-population
#7
Mohamed Mahmoud Fouad, Sherien Mohamed Farag, Mohamed I Hegazy, Mohamed Abd Elalem Aziz
Introduction Determining the prognosis of ischemic stroke is important for neurologists and patients. The aim is to study the predictors of three months clinical outcome in ischemic stroke patients. Materials and methods A total of 397 patients were classified according to three months modified Rankin Scale score (mRS score) into two groups, favorable and unfavorable outcome. Favorable outcome was assumed if the score was zero or one, or unchanged if the score was ≥ 1 before the onset of the most recent event...
June 26, 2017: Curēus
https://www.readbyqxmd.com/read/28855432/prospective-study-on-the-incidence-of-cerebrovascular-disease-after-coronary-angiography
#8
Akihiro Tokushige, Masaaki Miyata, Takeshi Sonoda, Ippei Kosedo, Daisuke Kanda, Takuro Takumi, Yuichi Kumagae, Yoshihiko Fukukura, Mitsuru Ohishi
AIM: Previous studies have reported a 10.2%-22% rate of silent cerebral infarction and a 0.1%-1% rate of symptomatic cerebral infarction after coronary angiography (CAG). However, the risk factors of cerebral infarction after CAG have not been fully elucidated. For this reason, we investigated the incidence and risk factors of CVD complications within 48 h after CAG using magnetic resonance imaging (MRI) (Diffusion-weighted MRI) at Kagoshima University Hospital. METHODS: From September 2013 to April 2015, we examined the incidence and risk factors, including procedural data and patients characteristics, of cerebrovascular disease after CAG in consecutive 61 patients who underwent CAG and MRI in our hospital...
August 30, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28673480/association-of-descending-thoracic-aortic-plaque-with-brain-atrophy-and-white-matter-hyperintensities-the-framingham-heart-study
#9
Hugo J Aparicio, Rodica E Petrea, Joseph M Massaro, Warren J Manning, Noriko Oyama-Manabe, Alexa S Beiser, Carlos S Kase, Ralph B D'Agostino, Philip A Wolf, Ramachandran S Vasan, Charles DeCarli, Christopher J O'Donnell, Sudha Seshadri
BACKGROUND AND AIMS: Aortic atherosclerosis is an aggregate marker of vascular risk factor exposure and has been associated with intracranial atherosclerosis and stroke. We hypothesized that atherosclerosis of the descending aorta (DAo) could be a risk marker for brain aging and injury. METHODS: We evaluated 1527 participants (mean age 59.9 years, 53.5% women) in the Framingham Offspring cohort who underwent both aortic and brain MRI. Participants were free of clinical stroke, dementia, or other neurological illness at the time of axial MRI of the thoracic and abdominal DAo and subsequent brain MRI...
October 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28648478/imaging-vulnerable-plaques-by-targeting-inflammation-in-atherosclerosis-using-fluorescent-labeled-dual-ligand-microparticles-of-iron-oxide-and-magnetic-resonance-imaging
#10
Joyce M S Chan, Claudia Monaco, Marzena Wylezinska-Arridge, Jordi L Tremoleda, Jennifer E Cole, Michael Goddard, Maggie S H Cheung, Kishore K Bhakoo, Richard G J Gibbs
OBJECTIVE: Identification of patients with high-risk asymptomatic carotid plaques remains an elusive but essential step in stroke prevention. Inflammation is a key process in plaque destabilization and a prelude to clinical sequelae. There are currently no clinical imaging tools to assess the inflammatory activity within plaques. This study characterized inflammation in atherosclerosis using dual-targeted microparticles of iron oxide (DT-MPIO) as a magnetic resonance imaging (MRI) probe...
June 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28631982/carotid-intraplaque-hemorrhage-on-vessel-wall-mri-does-not-correlate-with-tcd-emboli-monitoring-in-patients-with-recently-symptomatic-carotid-atherosclerosis
#11
Adam de Havenon, David Tirschwell, Jennifer J Majersik, Scott McNally, Gregory Stoddard, Anne Moore, Mahmud Mossa-Basha
Background Carotid intraplaque hemorrhage (IPH) seen on vessel wall MRI is associated with an increased risk of stroke or transient ischemic attack, as are microembolic signals (MES) detected by transcranial Doppler (TCD). We sought to examine the association between IPH and MES in acute stroke patients with symptomatic carotid atherosclerosis. Methods Through a retrospective chart review, we included patients from 2011 to 2013 with acute ischemic stroke due to carotid atherosclerosis of varying stenosis who had both 3D volumetric MRI of the neck and TCD emboli monitoring...
October 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28617385/-differential-diagnosis-of-cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy
#12
A A Moroz, N Yu Abramycheva, M S Stepanova, R N Konovalov, S L Timerbaeva, S N Illarioshkin
Cerebral autosomal dominant arteriopathy with subcortical infarctions and leucoencephalopathy (CADASIL) is an inherited CNS disease, which is caused by mutations in the NOTCH3 gene. Selective disorders of small vessels underlie the disease pathogenesis. Clinically CADASIL is characterized by headaches, multiple stroke-like disorders (in most cases transient ischemic attacks and lacunar strokes), and different focal neurological symptoms and dementia. There are specific MRI signs of the disease: multiple lacunar infarctions located in the basal ganglia, brain steam and cerebellum, focal lesions of temporal poles, capsula externa, periventricular and subcortical areas; diffuse white matter changes and leukoaraiosis can be observed as well...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28608454/accelerated-atherosclerosis-in-anca-associated-vasculitis
#13
I González-Suárez, J J Ríos-Blanco, J Arpa
OBJECTIVES: Cardiovascular disease, including myocardial infarction and stroke, is a major cause of mortality in ANCA-associated vasculitis (AAV). Although AAV affects small vessels, an accelerated atherosclerosis not explained by traditional cardiovascular risk factors (CVRF) has been demonstrated. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cerebral small vessel disease in AAV-patients. MATERIALS & METHODS: Twenty-three AAV-patients in complete remission were recruited...
June 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28543314/subclinical-hypothyroidism-and-risk-of-cerebral-small-vessel-disease-a-hospital-based-observational-study
#14
Xiaohao Zhang, Yi Xie, Caixia Ding, Jing Xiao, Yinyan Tang, Xuemei Jiang, Hua Shan, Yuankai Lin, Yujia Zhu, Chuanyou Li, Dan Hu, Zhixiang Ling, Gelin Xu, Lei Sheng
OBJECTIVE: Subclinical hypothyroidism (SCH) has been associated with atherosclerosis and increased risk of ischaemic stroke. However, whether SCH is associated with cerebral small vessel disease (cSVD) remains largely unexplored. This study aimed to investigate the relationship between SCH and total cSVD burden, a composite measurement detected with magnetic resonance imaging (MRI), in patients with minor ischaemic stroke or transient ischaemic attack (TIA). DESIGN: This was a prospective observational cohort study conducted in a tertiary referral hospital...
May 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28469441/magnetic-resonance-imaging-detection-of-intraplaque-hemorrhage
#15
REVIEW
J Scott McNally, Seong-Eun Kim, Jason Mendes, J Rock Hadley, Akihiko Sakata, Adam H De Havenon, Gerald S Treiman, Dennis L Parker
Carotid artery atherosclerosis is a major cause of ischemic stroke. For more than 30 years, future stroke risk and carotid stroke etiology have been determined using percent diameter stenosis based on clinical trials in the 1990s. In the past 10 years, magnetic resonance imaging (MRI) sequences have been developed to detect carotid intraplaque hemorrhage. By detecting carotid intraplaque hemorrhage, MRI identifies potential stroke sources that are often overlooked by lumen imaging. In addition, MRI can dramatically improve assessment of future stroke risk beyond lumen stenosis alone...
2017: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/28426728/pulmonary-vascular-volume-impaired-left-ventricular-filling-and-dyspnea-the-mesa-lung-study
#16
Carrie P Aaron, Eric A Hoffman, Joao A C Lima, Steven M Kawut, Alain G Bertoni, Jens Vogel-Claussen, Mohammadali Habibi, Katja Hueper, David R Jacobs, Ravi Kalhan, Erin D Michos, Wendy S Post, Martin R Prince, Benjamin M Smith, Bharath Ambale-Venkatesh, Chia-Ying Liu, Filip Zemrak, Karol E Watson, Matthew Budoff, David A Bluemke, R Graham Barr
BACKGROUND: Evaluation of impaired left ventricular (LV) filling has focused on intrinsic causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced LV filling and dyspnea. We hypothesized that lower total pulmonary vascular volume (TPVV) on computed tomography (CT) would be associated with dyspnea and decrements in LV end-diastolic volume, particularly among ever-smokers. METHODS: The Multi-Ethnic Study of Atherosclerosis recruited adults without clinical cardiovascular disease in 2000-02...
2017: PloS One
https://www.readbyqxmd.com/read/28348599/a-rare-case-of-stroke-secondary-to-iron-deficiency-anemia-in-a-young-female-patient
#17
Kavitha Gopalratnam, Kevin Andrew Woodson, Jigarkumar Rangunwala, Kanaga Sena, Manisha Gupta
Ischemic strokes occur when there is a sudden obstruction of an artery supplying blood flow to an area of the brain, leading to a focal neurological deficit. Strokes can be thrombotic or embolic in etiology and are associated with underlying conditions such as hypertension and atherosclerosis. Possible etiologies of strokes include cardioembolic disease, hematologic disorders, connective tissue disorders, and substance abuse or can be cryptogenic. Most stroke cases are seen in patients over 65 years of age...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28289478/cerebral-white-matter-hyperintensities-on-mri-and-acceleration-of-epigenetic-aging-the-atherosclerosis-risk-in-communities-study
#18
Abhay Raina, Xiaoping Zhao, Megan L Grove, Jan Bressler, Rebecca F Gottesman, Weihua Guan, James S Pankow, Eric Boerwinkle, Thomas H Mosley, Myriam Fornage
BACKGROUND: Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and dementia. We investigated the association of cerebral WMH burden on MRI with a DNA methylation-based biomarker of aging, termed DNA methylation age acceleration, which represents the deviation of the DNA methylation-predicted age from the chronologic age. RESULTS: In this cross-sectional observational study of 713 African-American participants of the Atherosclerosis Risk in Communities study, aged 51-73 years, estimates of predicted age were obtained based on two algorithms (Hannum et al...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28279371/carotid-plaque-lipid-content-and-fibrous-cap-status-predict-systemic-cv-outcomes-the-mri-substudy-in-aim-high
#19
RANDOMIZED CONTROLLED TRIAL
Jie Sun, Xue-Qiao Zhao, Niranjan Balu, Moni B Neradilek, Daniel A Isquith, Kiyofumi Yamada, Gádor Cantón, John R Crouse, Todd J Anderson, John Huston, Kevin O'Brien, Daniel S Hippe, Nayak L Polissar, Chun Yuan, Thomas S Hatsukami
OBJECTIVES: The aim of this study was to investigate whether and what carotid plaque characteristics predict systemic cardiovascular outcomes in patients with clinically established atherosclerotic disease. BACKGROUND: Advancements in atherosclerosis imaging have allowed assessment of various plaque characteristics, some of which are more directly linked to the pathogenesis of acute cardiovascular events compared to plaque burden. METHODS: As part of the event-driven clinical trial AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes), subjects with clinically established atherosclerotic disease underwent multicontrast carotid magnetic resonance imaging (MRI) to detect plaque tissue composition and high-risk features...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28181217/hypercoagulability-and-migraine
#20
Gretchen E Tietjen, Stuart A Collins
BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms...
February 9, 2017: Headache
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