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subclinical hypothyroidism

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https://www.readbyqxmd.com/read/28923288/delaying-thyroxine-until-positive-beta-human-chorionic-gonadotropin-is-safe-for-patients-receiving-fertility-therapy-applying-new-ata-guidelines-to-subclinical-hypothyroidism
#1
Alyse S Goldberg, Shoba Sujana Kumar, Ellen Greenblatt, Iliana C Lega, Heather Shapiro
OBJECTIVE: This study sought to examine the effect of changing TSH threshold recommendations from 2.5 to 4 mIU/L before fertility therapy on the prevalence of early gestational subclinical hypothyroidism (SCH) (TSH2 >2.5 mIU/L) and to evaluate implications on progression to clinical pregnancy (defined as detection of cardiac activity on ultrasound). METHODS: A retrospective chart review was performed in an academic fertility clinic on all patients with a measured pre-treatment TSH (TSH1) and positive beta-human chorionic gonadotropin following fertility treatment...
September 8, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28918836/role-of-microalbuminuria-in-predicting-cardiovascular-mortality-in-individuals-with-subclinical-hypothyroidism
#2
Tushar A Tuliani, Maithili Shenoy, Kevin Belgrave, Abhishek Deshmukh, Sadip Pant, Anthony Hilliard, Luis Afonso
PURPOSE: Studies suggest that subclinical hypothyroidism (SCH) is related to cardiovascular mortality (CVM). We explored the role of microalbuminuria (MIA) as a predictor of long-term CVM in population with and without SCH with normal kidney function. MATERIALS AND METHODS: We examined the National Health and Nutrition Education Survey - III database (n = 6,812). Individuals younger than 40 years, thyroid-stimulating hormone levels ≥20 and ≤0.35mIU/L, estimated glomerular filtration rate <60mL/minute/1...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#3
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetrical outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: To examine the association between pre-pregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery (PTD), gestational diabetes (GDM), and preeclampsia. STUDY DESIGN: Secondary analysis of a prospective cohort of 18-40 year old women with 1-2 prior pregnancy losses (n=1193) participating in a multi-center randomized, placebo-controlled trial of low-dose aspirin...
September 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28913145/subclinical-hypothyroidism-is-it-important-in-intracytoplasmic-sperm-injection-cycles
#4
Eray Çalışkan, Rahime Nida Ergin, Deniz Can Öztekin, Bülent Kars, Seda Çakır, Kenan Sofuoğlu
OBJECTIVE: To compare intracytoplasmic sperm injection (ICSI) outcomes of women with subclinical hypothyroidism with those of euthyroid women. MATERIALS AND METHODS: A retrospective case-control study was conducted. Out of 2529 ICSI cycles evaluated, 41 women with hypothyroidism, 28 women with hyperthyroidism, and 128 women with subclinical hyperthyroidism were excluded, and 2336 cycles were analyzed. Women were identified as having subclinical hypothyroidism (case group, n=105) in the presence of a thyroid-stimulating hormone level >4...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28875606/the-relationship-between-subclinical-thyroid-disease-and-cardiovascular-disease-risk-score-in-koreans
#5
Hee Joong Lim, Seong Hee Ahn, Seongbin Hong, Young Ju Suh
Subclinical hyperthyroidism and subclinical hypothyroidism are characterized by abnormal thyroid stimulating hormone (TSH) with normal free thyroxine. Subclinical thyroid diseases, to date, have received less attention compared with other thyroid diseases since they are asymptomatic. This study aimed to verify the association between subclinical thyroid diseases and cardiovascular diseases (CVDs) risk score in the Korean population. This was a population-based cohort study using data collected from 3,722 subjects (aged ≥ 30 years) during the 6th Korea National Health and Nutrition Examination Survey (KNHANES VI; 2013-2015)...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28872553/hybrid-spect-ct-helps-characterization-and-localization-of-a-dual-thyroid-ectopia
#6
Yasser Abdelhafez, Maha Khalil, Esraa Roshdy, Waleed A Diab, Lobna Eltoni
The presence of ectopic thyroid tissue in 2 or more different sites is rare. A 12-year-old girl presented with midline anterior neck swelling in the infrahyoid region with subclinical hypothyroidism. Thyroid scanning with Tc-pertechnetate was performed, and SPECT/CT was ordered for further evaluation. Two hyperdense lesions demonstrating intense radiotracer uptake were seen in the midline at the base of the tongue and infrahyoid neck. We emphasis the role of hybrid SPECT/CT for characterization and localization of suspected ectopic thyroid tissue...
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28872086/-subclinical-hypothyroidism-and-endocrine-metabolic-characteristics-in-women-with-polycystic-ovary-syndrome
#7
Fangzhi Yue, Dongmei Zhang, Fei Gong, Li Zhang, Zhixiang Sun, Minxiang Lei
To explore associations of subclinical hypothyroidism (SCH) with endocrine metabolic characteristics in women with polycystic ovary syndrome (PCOS).
 Methods: A total of 321 women who were newly diagnosed as PCOS were recruited from two endocrine outpatient clinics. The diagnosis of PCOS was established according to the 2003 Rotterdam consensus criteria. Thyroid function was examined by chemiluminescent immunoassay. Patients who had normal free thyroxine (FT4) were divided into different SCH subgroups according to two thyroid stimulating hormone (TSH) cutoff points (4...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28868261/nonalcoholic-fatty-liver-disease-is-not-associated-with-thyroid-hormone-levels-and-hypothyroidism-a-systematic-review-and-meta-analysis
#8
Veeravich Jaruvongvanich, Anawin Sanguankeo, Sikarin Upala
BACKGROUND: Whether hypothyroidism is related to nonalcoholic fatty liver disease (NAFLD) is unclear. Thyroid dysfunction is closely related with components of metabolic syndrome. Given the hepatic manifestation of metabolic syndrome, several studies have investigated the association between NAFLD and thyroid dysfunction and have demonstrated inconsistent results. Thus, we conducted a systematic review and meta-analysis to better characterize the association between NAFLD and thyroid dysfunction...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28868249/should-subclinical-hypothyroidism-be-an-exclusion-criterion-for-the-diagnosis-of-polycystic-ovary-syndrome
#9
Sebastião Freitas de-Medeiros, Márcia Marly Winck Yamamoto, Matheus Antônio Souto de-Medeiros, Jacklyne Silva Barbosa, Robert John Norman
BACKGROUND: The purpose of the study was to examine whether patients with subclinical hypothyroidism (SCH) should be excluded before making a diagnosis of polycystic ovary syndrome (PCOS). METHODS: Seven hundred sixteen patients, 462 with true PCOS, 31 with PCOS-SCH, and 223 normal cycling women were enrolled. Clinical, metabolic, and hormonal parameters among the groups were investigated. Continuous variables were compared by one-way analysis of variance. Proportions were compared using Z test...
April 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28854871/unstable-thyroid-function-in-older-adults-is-caused-by-alterations-in-both-thyroid-and-pituitary-physiology-and-associated-with-increased-mortality
#10
Jennifer Sophie Mammen, John McGready, Paul W Ladenson, Eleanor M Simonsick
BACKGROUND: Average thyrotropin (TSH) levels are known to be higher in older adults when measured in cross-sectional populations. Possible etiologies include differential survival, neutral aging changes, or increased disease prevalence at older ages. This study aimed to elucidate the mechanisms underlying changing thyroid function during aging, and to determine the association of changes with survival, by analyzing the individual thyroid axis over time. METHODS: Individual patterns of changing TSH and free thyroxine (FT4) were determined in 640 participants in the Baltimore Longitudinal Study of Aging who had at least three measures of serum TSH and FT4, not on medications, over an average of 7 years follow up...
August 30, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28854714/routine-serum-thyroid-stimulating-hormone-testing-optimizing-pre-conception-health-or-generating-toxic-knowledge
#11
Abha Maheshwari, Priya Bhide, Jyotsna Pundir, Siladitya Bhattacharya
Monitoring subclinical hypothyroidism (SCH) in women is believed to be important in terms of preventing overt hypothyroidism and optimizing the health and cognitive development of their children. Current systematic reviews have suggested an association between maternal SCH and adverse obstetric and neonatal outcomes. However, initiating the administration of thyroxine during pregnancy has failed to demonstrate appreciable health benefits. Hence there are calls by professional endocrine societies for optimizing serum thyroid-stimulating hormone (TSH) levels pre-conception...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28853052/thyroid-diseases-and-bone-health
#12
REVIEW
G R Williams, J H D Bassett
Thyroid hormones are essential for skeletal development and are important regulators of bone maintenance in adults. Childhood hypothyroidism causes delayed skeletal development, retarded linear growth and impaired bone mineral accrual. Epiphyseal dysgenesis is evidenced by classic features of stippled epiphyses on X-ray. In severe cases, post-natal growth arrest results in a complex skeletal dysplasia. Thyroid hormone replacement stimulates catch-up growth and bone maturation, but recovery may be incomplete dependent on the duration and severity of hypothyroidism prior to treatment...
August 29, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28829155/efficacy-and-safety-of-ashwagandha-root-extract-in-subclinical-hypothyroid-patients-a-double-blind-randomized-placebo-controlled-trial
#13
Ashok Kumar Sharma, Indraneel Basu, Siddarth Singh
BACKGROUND: Subclinical hypothyroidism, a thyroid disorder without obvious symptoms of thyroid deficiency, occurs in 3%-8% of the global population. Ashwagandha [Withania somnifera (L.) Dunal], a traditional medicine in Ayurveda, is often prescribed for thyroid dysfunctions. OBJECTIVE: This pilot study was designed to evaluate the efficacy and safety of ashwagandha root extract in subclinical hypothyroid patients. DESIGN, SETTING, AND PARTICIPANTS: A prospective, randomized, double-blind, single-center placebo-controlled study was performed at Sudbhawana Hospital, Varanasi, India between May 2016 and September 2016...
August 22, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28828047/type-1-diabetes-and-thyroid-autoimmunity-in-children
#14
Anca Orzan, Carmen Novac, Mihaiela Mihu, Constantin Ionescu Tirgoviste, Mihaela Balgradean
INTRODUCTION: Autoimmune thyroid disease and type 1 diabetes (T1DM) are two autoimmune diseases frequently associated, especially in pediatric population. Aims: we wanted to determine and ilustrate the relationship between type 1 diabetes and autoimmune thyroiditis and also the factors than can influence it, like gender, age, diabetes duration. Glycemic control was also evaluated for all the patients. MATERIAL AND METHODS: There were studied 256 patients, children and adolescents with T1DM (male/ female: 145/115; 55%/45%)...
December 2016: Mædica
https://www.readbyqxmd.com/read/28821377/ischemic-stroke-and-impact-of-thyroid-profile-at-presentation-a-systematic-review-and-meta-analysis-of-observational-studies
#15
Rashmi Dhital, Dilli Ram Poudel, Niranjan Tachamo, Bishal Gyawali, Sijan Basnet, Pragya Shrestha, Paras Karmacharya
BACKGROUND: Stroke is the fifth leading cause of mortality in the United States and a leading cause of disability. A complex relationship between thyroid hormone levels and severity of, and outcome after, stroke has been described. AIM: Our objective is to identify the association between baseline thyroid function profile and outcome after acute ischemic stroke. METHODS: Studies looking at the association between thyroid function and functional stroke outcomes were identified from available electronic databases from inception to December 16, 2016...
August 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28813223/subclinical-hypothyroidism-or-hypothyroxinemia-in-pregnancy
#16
LETTER
Brian M Casey, Elizabeth A Thom
New England Journal of Medicine, Volume 377, Issue 7, Page 700-701, August 2017.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28813222/subclinical-hypothyroidism-or-hypothyroxinemia-in-pregnancy
#17
LETTER
Laszlo Hegedüs, Thomas H Brix
No abstract text is available yet for this article.
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28806795/in-older-adults-with-subclinical-hypothyroidism-levothyroxine-did-not-improve-symptoms-or-tiredness
#18
Reema Shah
No abstract text is available yet for this article.
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28796656/hypothyroidism-potentially-linked-to-cutaneous-squamous-cell-carcinoma-retrospective-study-at-a-single-tertiary-academic-medical-center
#19
Omeed Ahadiat, Shauna Higgins, Cameron Trodello, Guy Talmor, Niels Kokot, Ashley Wysong
BACKGROUND: There are multiple known risk factors for the development of cutaneous squamous cell carcinoma (SCC). OBJECTIVE: To determine whether patients with cutaneous SCC have a higher prevalence of hypothyroidism than the general US population. MATERIALS AND METHODS: A retrospective review was performed for patients seen at the University of Southern California with cutaneous SCC. Chart review was performed for the presence of hypothyroidism and thyroid replacement therapy before the diagnosis of SCC for each patient...
August 7, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28775130/occupational-pesticide-exposure-and-subclinical-hypothyroidism-among-male-pesticide-applicators
#20
Catherine C Lerro, Laura E Beane Freeman, Curt T DellaValle, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Farzana Jasmine, Stella Koutros, Christine G Parks, Dale P Sandler, Michael C R Alavanja, Jonathan N Hofmann, Mary H Ward
OBJECTIVES: Animal studies suggest that exposure to pesticides may alter thyroid function; however, few epidemiologic studies have examined this association. We evaluated the relationship between individual pesticides and thyroid function in 679 men enrolled in a substudy of the Agricultural Health Study, a cohort of licensed pesticide applicators. METHODS: Self-reported lifetime pesticide use was obtained at cohort enrolment (1993-1997). Intensity-weighted lifetime days were computed for 33 pesticides, which adjusts cumulative days of pesticide use for factors that modify exposure (eg, use of personal protective equipment)...
August 3, 2017: Occupational and Environmental Medicine
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