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subclinical hypothyroidism

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https://www.readbyqxmd.com/read/29353219/blocking-mitochondrial-cyclophilin-d-ameliorates-tsh-impaired-defensive-barrier-of-artery
#1
Xiaojing Liu, Heng Du, Qiang Chai, Qing Jia, Lu Liu, Meng Zhao, Jun Li, Hui Tang, Wenbin Chen, Lifang Zhao, Li Fang, Ling Gao, Jiajun Zhao
AIMS: Endothelial cells (ECs) constitute the defensive barrier of vasculature, which maintains the vascular homeostasis. Mitochondrial oxidative stress (mitoOS) in ECs significantly affects the initiation and progression of vascular diseases. The higher serum thyroid stimulating hormone (TSH) level is being recognized as a nonconventional risk factor responsible for the increased risk of cardiovascular diseases in subclinical hypothyroidism (SCH). However, effects and underlying mechanisms of elevated TSH on ECs are still ambiguous...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29348381/thyroid-dysfunction-in-type-2-diabetes-mellitus-patients
#2
Imam Subekti, Laurentius Aswin Pramono, Esthika Dewiasty, Dante Saksono Harbuwono
BACKGROUND: thyroid dysfunction is more likely to occur in diabetes mellitus patients than general population. Until now, no study has been done to find prevalence of hypothyroidism and hyperthyroidism in Indonesian diabetics. This study aimed to find the proportion and characteristics of thyroid dysfunction in Indonesian type 2 diabetes mellitus patients. METHODS: a cross-sectional study was conducted in Endocrine and Diabetes Polyclinic, Department of Internal Medicine, Cipto Mangunkusumo Hospital from July to September 2015...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29343652/painless-thyroiditis-and-fulminant-type-1-diabetes-mellitus-in-a-patient-treated-with-an-immune-checkpoint-inhibitor-nivolumab
#3
Kanako Sakurai, Satsuki Niitsuma, Ryota Sato, Kazuhiro Takahashi, Zenei Arihara
The programmed cell death-1 (PD-1) pathway is a novel therapeutic target in immune checkpoint therapy for cancer. Nivolumab, an anti-PD-1 monoclonal antibody, blocks PD-1 and can restore anti-cancer immune responses by disrupting the signal that inhibits T-cell activation. Nivolumab may induce endocrine-related adverse events, including hypophysitis, autoimmune thyroiditis, and type 1 diabetes mellitus. Here we report a 68-year-old female patient with advanced renal cell carcinoma who was treated with nivolumab...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29341525/-general-internal-medicine%C3%A2-2017-scientific-breakthroughs-in-ambulatory-care
#4
Alexandre Gouveia, Lionel De Alencastro, Yvonne Fierz, Lionel Koehli, Alexandre Béguelin, Olivier Pasche, Kevin Selby, Patrick Bodenmann
Bariatric surgery improves glycemic control in obese patients with diabetes type 2. Dual antiplatelet therapy can be maintained beyond 12 months after a myocardial infarction. Levothyroxine is not beneficial among patients ≥ 65 years that have subclinical hypothyroidism. Prophylactic anticoagulation in lower limb immobilisation should be reserved only for patients with a high risk of thromboembolism. A diagnosis of asthma should be initially confirmed by a spirometry if clinically suspected. A proton pump inhibitor is indicated for patients ≥ 65 years that are treated with aspirin...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29340281/urgent-need-to-define-pretreatment-predictors-of-immune-check-point-inhibitors-related-endocrinopathies-a-case-report-and-review-of-literature
#5
Vishal Sehgal, Richard Childress
Immune check point inhibitors have revolutionized the treatment of metastatic malignancies. They are a promising area in oncology and more drugs are likely to be available in the coming years. Along with the promise of better response oncologically, there is an increased incidence of endocrinopathies related to autoimmunity. This case report illustrates the dramatic development of hypothyroidism in a patient with underlying subclinical hyperthyroidism. It also suggests the potential pretreatment predictors of endocrinopathies related to these immune check point inhibitors...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29333819/hashimoto-s-disease-in-a-cohort-of-29-children-and-adolescents-epidemiology-clinical-course-and-comorbidities-in-the-short-and-long-term
#6
Eliot Gómez López, Ana P Nso-Roca, Mercedes Juste Ruiz, Ernesto Cortés Castell
Hashimoto's thyroiditis is the most common cause of goiter and hypothyroidism among children and adolescents. Its clinical manifestations and course vary. The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in the pediatric population. Clinical, analytical, ultrasound, epidemiological, and evolutionary data of patients with autoimmune thyroiditis seen at Hospital Universitario San Juan de Alicante between January 2010 and January 2016 were analyzed...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29325223/maternal-thyroid-hormone-insufficiency-during-pregnancy-and-risk-of-neurodevelopmental-disorders-in-offspring-a-systematic-review-and-meta-analysis
#7
William Thompson, Ginny Russell, Genevieve Baragwanath, Justin Matthews, Bijay Vaidya, Jo Thompson-Coon
BACKGROUND: In the last two decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results. AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes...
January 11, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29319359/secondary-and-tertiary-preventions-of-thyroid-disease
#8
Fereidoun Azizi, Ladan Mehran, Farhad Hosseinpanah, Hossein Delshad, Atieh Amouzegar
INTRODUCTION: Secondary and tertiary preventions are concerned with the recognition of the disease process in a very early stage and delay in progression to complete disease and minimization of complications and the impact of illness. METHODS: All articles related to secondary and tertiary prevention of thyroid diseases were reviewed. Using related key words, articles published between 2001 and 2015 were evaluated, categorized, and analyzed. RESULTS: In secondary prevention, congenital hypothyroidism and subclinical hypo and hyperthyroidism are equally important...
January 10, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29319127/sexual-function-and-depressive-symptoms-in-young-men-with-hypothyroidism-receiving-levothyroxine-liothyronine-combination-therapy
#9
Robert Krysiak, Bogdan Marek, Bogusław Okopień
INTRODUCTION: Both overt and subclinical hypothyroidism are often accompanied by sexual dysfunction. Despite improving male sexual functioning, levothyroxine treatment does not always restore all its aspects. The aim of this study was to compare male sexual functioning and depressive symptoms between men with hypothyroidism receiving levothyroxine/liothyronine combination therapy and men receiving levothyroxine alone. MATERIAL AND METHODS: The study population consisted of 21 young levothyroxine-treated men with clinical symptoms of hypothyroidism in whom serum thyrotropin and thyroid hormone levels were within the normal limits...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29317172/impact-of-positive-thyroid-autoimmunity-on-pregnant-women-with-subclinical-hypothyroidism
#10
Cristina López-Tinoco, Amparo Rodríguez-Mengual, Almudena Lara-Barea, Julia Barcala, Laura Larrán, Ana Saez-Benito, Manuel Aguilar-Diosdado
BACKGROUND: The impact of subclinical hypothyroidism (SH) and thyroid autoimmunity on obstetric and perinatal complications continues to be a matter of interest and highly controversial. AIM: To assess the impact of SH and autoimmunity in early pregnancy on the obstetric and perinatal complications in our population. MATERIAL AND METHOD: A retrospective cohort study in 435 women with SH (TSH ranging from 3.86 and 10 μIU/mL and normal FT4 values) in the first trimester of pregnancy...
January 6, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29316865/effects-of-thyroid-stimulating-hormone-on-peripheral-thyroid-hormone-metabolism-and-serum-lipids
#11
Carolien M Beukhof, Elske Theresia Massolt, Theo J Visser, Tim Korevaar, Marco Medici, Wouter W de Herder, Jeanine Roeters van Lennep, Monique Mulder, Yolanda B de Rijke, Christoph Reiners, Frederik A Verburg, Robin Peeters
BACKGROUND: Subclinical hypothyroidism is associated with dyslipidemia and atherosclerosis. Whether part of these effects are mediated via direct effects of TSH on peripheral TH metabolism and/or concentrations of serum lipids is not clear. OBJECTIVE: To examine whether thyroid stimulating hormone (TSH) has direct effects on peripheral thyroid hormone (TH) metabolism and serum lipids. METHODS: We retrospectively analyzed 82 patients with differentiated thyroid cancer...
January 9, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29306458/impact-of-subclinical-hypothyroidism-on-clinical-outcomes-following-percutaneous-coronary-intervention
#12
Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Jinkyu Park, Jinho Shin
BACKGROUND: Similar to overt hypothyroidism, subclinical hypothyroidism (SCH) has been reported to increase the risk of cardiovascular disease. However, the influence of SCH on clinical outcomes following percutaneous coronary intervention (PCI) remains unclear. METHODS: We performed a prospective cohort study. SCH was defined as a thyroid-stimulating hormone (TSH) level ≥4.5mIU/l and a normal level of free thyroxine (FT4). A composite event was defined as the combination of cardiac death, non-fatal myocardial infarction (MI) and repeat revascularization...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29297967/levothyroxine-supplementation-improves-serum-anti-m%C3%A3-llerian-hormone-levels-in-infertile-patients-with-hashimoto-s-thyroiditis
#13
Masako Kuroda, Keiji Kuroda, Tomoya Segawa, Jaeduk Y Noh, Ai Yoshihara, Koichi Ito, Hisao Osada, Satoru Takeda, Shokichi Teramoto
AIM: Thyroid dysfunction and autoimmunity are associated with an adverse effect on fertility. An aberrant high thyroid stimulating hormone level is associated with diminished ovarian reserve in women of reproductive age; however, the utility of levothyroxine (LT4) replacement for infertile patients with subclinical hypothyroidism is still under discussion. The aim of this study was to investigate whether LT4 supplementation for infertile patients with subclinical hypothyroidism improves impaired ovarian function...
January 3, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29285444/optimal-levothyroxine-replacement-adequately-improves-symptoms-of-hypothyroidism-residual-symptoms-need-further-evaluation-for-other-than-hypothyroidism-causation
#14
Rekha Singh, Ashwani Tandon, Sushil Kumar Gupta, K Saroja
Objectives: Many patients with hypothyroidism complain of persistent residual symptoms, despite optimal treatment, although the similar prevalence is seen in patients with documented absence of thyroid disorder in primary health-care setup. We aimed to investigate symptomatic relief in new cases of primary hypothyroidism and compare with controls with other chronic conditions. Methods: This prospective case-control follow-up study enrolled patients from July 2014 to May 2015 in an endocrine outpatient clinic of a tertiary hospital...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29285443/cardiovascular-risk-factors-in-children-and-adolescents-with-subclinical-hypothyroidism
#15
Yogesh Yadav, Uma Kaimal Saikia, Dipti Sarma, Manoj Hazarika
Background: Subclinical hypothyroidism (SCH) is a commonly encountered entity in day-to-day clinical practice and has been associated with adverse cardiovascular risk profile in adults and children. Data on children and adolescents with SCH, from India, are limited. Materials and Methods: This study was a cross-sectional case-control study, conducted at a tertiary care center in Northeast India. Twenty-seven children and adolescents aged 11 ± 2.4 years with SCH and thyroid-stimulating hormone >7...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29280293/subclinical-hypothyroidism-a-common-finding-in-adult-patients-with-cyanotic-congenital-heart-disease
#16
Peter Bak, Cristel S Hjortshøj, Peter Gaede, Lars Idorn, Lars Søndergaard, Annette S Jensen
OBJECTIVE: Cyanotic congenital heart disease is a systemic disease, with effects on multiple organ systems. A high prevalence of subclinical hypothyroidism (SCH) has been reported in a small cohort of cyanotic congenital heart disease patients. Subclinical hypothyroidism has been associated with various adverse cardiovascular effects, as well as an increased risk of progression to overt hypothyroidism. The aim of this study was to examine the prevalence of SCH in cyanotic congenital heart disease patients, consider possible etiologies, and evaluate thyroid function over time...
December 27, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/29279270/prevalence-of-thyroid-disorders-in-north-indian-type-2-diabetic-subjects-a-cross-sectional-study
#17
Maaz Ozair, Saba Noor, Alok Raghav, Sheelu Shafiq Siddiqi, Anjum Mirza Chugtai, Jamal Ahmad
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major health burden worldwide with many patients encountering thyroid dysfunction later in their life. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexists. However, the prevalence of thyroid dysfunction and associated clinical variables in these patients has not been investigated. OBJECTIVES: The study aimed at determining the incidence and prevalence of thyroid dysfunction in patients with T2DM in relation to age, sex, metabolic syndrome and other co-morbid conditions...
December 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29276739/data-on-the-impact-of-subclinical-hypothyroidism-on-clinical-outcomes-following-percutaneous-coronary-intervention
#18
Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Jinkyu Park, Jinho Shin
This article contains the data showing the different influence of subclinical hypothyroidism (SCH) on the risk of cardiovascular events after percutaneous coronary intervention (PCI) in various subgroups regarding myocardial infarction, previous PCI, the stent generation, total stent length, the extent of coronary artery disease, diabetes mellitus, obesity, a lipid reduction level and a C-reactive protein level. This article also contains the data showing the association between SCH and the risk of receiving repeat PCI for in-stent restenosis or de novo coronary stenosis...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29275887/subclinical-hypothyroidism-is-associated-with-adverse-prognosis-in-heart-failure-patients
#19
Yu Sato, Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Shunsuke Watanabe, Yuki Kanno, Satoshi Abe, Makiko Miyata, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: It is widely recognized that overt hyper- as well as hypothyroidism are potential causes of heart failure (HF). Additionally it has been recently reported that subclinical hypothyroidism (sub-hypo) is associated with atherosclerosis, development of HF, and cardiovascular death. We aimed to clarify the effect of sub-hypo on prognosis of HF, and underlying hemodynamics and exercise capacity. METHODS: We measured the serum levels of thyroid stimulating hormone (TSH) and free thyroxine (FT4) in 1100 consecutive HF patients...
January 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29275875/subclinical-hypothyroidism-and-heart-failure-chicken-or-egg
#20
EDITORIAL
Sarah Parent, Bibiana Cujec
No abstract text is available yet for this article.
January 2018: Canadian Journal of Cardiology
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