keyword
MENU ▼
Read by QxMD icon Read
search

Scrub typhus

keyword
https://www.readbyqxmd.com/read/29760694/dissemination-of-orientia-tsutsugamushi-a-causative-agent-of-scrub-typhus-and-immunological-responses-in-the-humanized-draga-mouse
#1
Le Jiang, Erin K Morris, Rodrigo Aguilera-Olvera, Zhiwen Zhang, Teik-Chye Chan, Soumya Shashikumar, Chien-Chung Chao, Sofia A Casares, Wei-Mei Ching
Scrub typhus is caused by Orientia tsutsugamushi , an obligated intracellular bacterium that affects over one million people per year. Several mouse models have been used to study its pathogenesis, disease immunology, and for testing vaccine candidates. However, due to the intrinsic differences between the immune systems in mouse and human, these mouse models could not faithfully mimic the pathology and immunological responses developed by human patients, limiting their value in both basic and translational studies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29746378/acute-encephalitis-syndrome-in-gorakhpur-uttar-pradesh-2016-clinical-and-laboratory-findings
#2
Mahima Mittal, Vijay Bondre, Manoj Murhekar, Hirawati Deval, Winsley Rose, Valsan Philip Verghese, Mahim Mittal, Gajanan Patil, R Sabarinathan, Jeromie Wesley Vivian Thangaraj, K Kanagasabai, John Antony Jude Prakash, Nivedita Gupta, Manish Gupte, Mohan D Gupte
BACKGROUND: Seasonal outbreaks of acute encephalitis syndrome (AES) with high fatality have been occurring in Gorakhpur, Uttar Pradesh, India for several years. We conducted investigations during the 2016 outbreak, to identify the etiology. METHODS: We included 407 hospitalized AES patients with CSF pleocytosis (>5 cells/cmm) in our study. These patients were clinically examined; their blood and CSF samples were collected and investigated for scrub typhus (ST), Japanese encephalitis virus (JEV), dengue virus and spotted fever group of rickettsia (SFGR) by serology and/or PCR...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29735837/diagnostic-performance-of-serological-tests-to-detect-antibodies-against-acute-scrub-typhus-infection-in-central-india
#3
Kiran Pote, Rahul Narang, Pradeep Deshmukh
Background: Differentiating scrub typhus from other acute febrile illness is difficult due to non specificity of clinical symptoms and relative absence of eschar in Indian population. The diagnosis thus relies mainly on laboratory tests. Antibody based serological tests are mainstay of scrub typhus diagnosis. Here, we evaluated the diagnostic performance of IgM ELISA, IgM IFA and ICT to detect antibodies against O. tsutsugamushi in acute serum of febrile patients. Methodology: The serum samples from 600 randomly selected patients suffering from acute undifferentiated fever were tested by all the three tests mentioned above...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29734393/orientia-tsutsugamushi-uses-two-ank-effectors-to-modulate-nf-%C3%AE%C2%BAb-p65-nuclear-transport-and-inhibit-nf-%C3%AE%C2%BAb-transcriptional-activation
#4
Sean M Evans, Kyle G Rodino, Haley E Adcox, Jason A Carlyon
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response. Here, we report that NF-κB p65 nuclear accumulation and NF-κB-dependent transcription are inhibited in O. tsutsugamushi infected HeLa cells and/or primary macrophages, even in the presence of TNFα. The bacterium modulates p65 subcellular localization by neither degrading it nor inhibiting IκBα degradation...
May 7, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29706479/scrub-typhus-diagnosis-on-acute-specimens-using-serological-and-molecular-assays-a-3-year-prospective-study
#5
Munegowda Koralur, Rahul Singh, Muralidhar Varma, Shalini Shenoy, Vasudeva Acharya, Asha Kamath, John Stenos, Eugen Athan, Indira Bairy
Scrub typhus (ST) is an underdiagnosed acute febrile illness in the Asia Pacific region with recent reemergence. Clinical diagnosis is difficult, and laboratory confirmation is largely based on serological and molecular tests. However, Weil-Felix test still remains the only test available in much of the rural tropics where a disproportionate number of cases occur. Sensitive and affordable assays are important for broader use and accurate diagnosis. We evaluated the diagnostic capabilities of serological and molecular assays on single acute clinical samples...
February 24, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29698425/complexity-of-type-specific-56-kda-antigen-cd4-t-cell-epitopes-of-orientia-tsutsugamushi-strains-causing-scrub-typhus-in-india
#6
Arunachalam Ramaiah, Munegowda C Koralur, Gregory A Dasch
Orientia tsutsugamushi (Ots) is an obligate, intracellular, mite-transmitted human pathogen which causes scrub typhus. Understanding the diversity of Ots antigens is essential for designing specific diagnostic assays and efficient vaccines. The protective immunodominant type-specific 56 kDa antigen (TSA) of Ots varies locally and across its geographic distribution. TSA contains four hypervariable domains. We bioinformatically analyzed 345 partial sequences of TSA available from India, most of which contain only the three variable domains (VDI-III) and three spacer conserved domains (SVDI, SVDII/III, SVDIII)...
2018: PloS One
https://www.readbyqxmd.com/read/29697421/a-case-report-and-literature-review-of-scrub-typhus-with-acute-abdomen-and-septic-shock-in-a-child-the-role-of-leukocytoclastic-vasculitis-and-granulysin
#7
Po-Hsiung Chang, Yu-Pin Cheng, Po-Sheng Chang, Chiao-Wei Lo, Lung-Huang Lin, Chin-Fang Lu, Wen-Hung Chung
Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. It has various systemic manifestations, including GI symptoms. In some, the illness progresses to multiorgan dysfunction syndrome and death...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29692908/metabolic-characterization-of-serum-from-mice-challenged-with-orientia-tsutsugamushi-infected-mites
#8
C-C Chao, B O Ingram, W Lurchachaiwong, W-M Ching
Scrub typhus is an acute zoonosis caused by the obligate intracellular Gram-negative bacterium Orientia tsutsugamushi. To better understand the host response elicited by natural infection by chigger feeding, ICR mice were infected by Leptotrombidium chiangraiensis (Lc1) chiggers, and the metabolic profiles of their serum were examined over several time points after initiation of feeding. ICR mice were infected by either naive Lc1 chiggers (i.e. not infected by O. tsutsugamushi, NLc1) or O. tsutsugamushi -infected Lc1 chiggers (OLc1)...
May 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29692489/scrub-typhus-atypical-presentation-in-subhimalayan-region
#9
Vivek S Guleria, Chetan Sharda, A K Sood, Virendra Kumar
No abstract text is available yet for this article.
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29685854/distribution-of-tick-borne-diseases-in-japan-past-patterns-and-implications-for-the-future
#10
REVIEW
Kayoko Yamaji, Hiroka Aonuma, Hirotaka Kanuka
The rapid geographical spread of tick-borne diseases (TBDs) worldwide has recently provoked significant concerns amongst public health authorities. Tick-borne pathogens are maintained in enzootic cycles involving ticks and wild animal hosts, with epizootic spread to other mammals, including livestock and humans. Despite the increasing public health concern, current TBD diagnostic tests and treatments are inadequate, and predictive models of future risks posed by TBDs are limited by the heterogeneity of environmental, vector, and host factors, even in neighboring regions...
April 20, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29685200/scrub-typhus-re-emergence-in-india-contributing-factors-and-way-forward
#11
Jai Ranjan, John Antony Jude Prakash
Scrub typhus is a mite borne infectious disease which has re-emerged in India in the 3rd millennium after years of quiescence. In this review, the authors hypothesize the various factors responsible for resurgence of this disease. The main drivers that could have contributed to the upsurge in scrub typhus cases in past two decades are changes in land use land cover (LULC) and urbanisation which are; as a result of the population explosion, causing a strain on sanitation and also increased diversion of forest land for agricultural use...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29663698/comparative-study-of-two-droplet-based-dissolving-microneedle-fabrication-methods-for-skin-vaccination
#12
Chisong Lee, Hongil Kim, Suyong Kim, Shayan F Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho, Hyungil Jung
Dissolving microneedles (DMNs) have been widely studied in medical applications due to their pain-free administration, superior efficiency, and safe drug delivery. In skin vaccination, preserving the activity of the encapsulated antigen is an important consideration, as antigen activity is lost during DMN fabrication because of various stress factors. These stress factors vary between fabrication methods and each method affects the antigen's activity to different degrees. In this study, the activity of encapsulated antigens delivered by DMNs is compared between two recently developed DMN fabrication methods; droplet-born air blowing (DAB) and centrifugal lithography (CL) for a model scrub typhus vaccine antigen, ScaA...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29653201/kinetics-of-igm-and-igg-antibodies-after-scrub-typhus-infection-and-the-clinical-implications
#13
George M Varghese, Veera Manikandan Rajagopal, Paul Trowbridge, Divya Purushothaman, Sherry Joseph Martin
OBJECTIVES: Serology detecting IgM antibodies is the most widely used test to diagnose scrub typhus infection. However, kinetics of IgM and IgG antibodies post-infection remains elusive which could contribute to false positivity. The objective of this study is to document the nature of evolution of these antibody titers after infection. METHODS: Adult patients previously confirmed to have scrub typhus using IgM ELISA or positive PCR or both were included in this cross-sectional study...
April 10, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29590177/emergence-of-orientia-tsutsugamushi-as-an-important-cause-of-acute-encephalitis-syndrome-in-india
#14
Parul Jain, Shantanu Prakash, Piyush K Tripathi, Archana Chauhan, Shikha Gupta, Umesh Sharma, Anil K Jaiswal, Devraj Sharma, Amita Jain
BACKGROUND: Acute Encephalitis Syndrome (AES) is a major seasonal public health problem in Bihar, India. Despite efforts of the Bihar health department and the Government of India, burden and mortality of AES cases have not decreased, and definitive etiologies for the illness have yet to be identified. OBJECTIVES: The present study was undertaken to study the specific etiology of AES in Bihar. METHODS: Cerebrospinal fluid and/or serum samples from AES patients were collected and tested for various pathogens, including viruses and bacteria by ELISA and/or Real Time PCR...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29584919/genetic-diversity-of-orientia-tsutsugamushi-strains-circulating-in-northeast-india
#15
Trishna Bora, Siraj Ahmed Khan, Lobsang Jampa, Basanta Laskar
Background: Scrub typhus, caused by the intracellular bacteria Orientia tsutsugamushi is widely distributed in Southeast Asian countries with antigenically divergent strains reported across the Asia-Pacific belt. The present study was conducted to characterize the circulating strains of Orientia tsutsugamushi prevailing in two Northeastern states of India-the gateway to most Southeast Asian countries. Methods: A total of 278 (98 clinical and 180 field collected) scrub typhus positive blood samples collected from December 2014 to December 2016 were subjected for amplification of partial 56 KDa, 47 KDa and 16SrRNA genes of Orientia...
March 12, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29581051/febrile-illness-in-asia-gaps-in-epidemiology-diagnosis-management-for-informing-health-policy
#16
REVIEW
Poojan Shrestha, Tamalee Roberts, Anousin Homsana, Tin Ohn Myat, John A Crump, Yoel Lubell, Paul N Newton
BACKGROUND: There is increasing evidence on the aetiology and management of fevers in Asia, the importance of which has risen with declines in malaria incidence. AIMS: To conduct a narrative review of the epidemiology and management of fevers in South and South-East Asia and to highlight gaps in our knowledge that impair evidence-based health policy decisions. SOURCES: A narrative review of papers published since 2012 of developments in fever epidemiology, diagnosis and treatment in South and South-East Asia...
March 23, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29579046/scrub-typhus-point-of-care-testing-a-systematic-review-and-meta-analysis
#17
Kartika Saraswati, Nicholas P J Day, Mavuto Mukaka, Stuart D Blacksell
BACKGROUND: Diagnosing scrub typhus clinically is difficult, hence laboratory tests play a very important role in diagnosis. As performing sophisticated laboratory tests in resource-limited settings is not feasible, accurate point-of-care testing (POCT) for scrub typhus diagnosis would be invaluable for patient diagnosis and management. Here we summarise the existing evidence on the accuracy of scrub typhus POCTs to inform clinical practitioners in resource-limited settings of their diagnostic value...
March 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29567888/prevalence-of-scrub-typhus-in-pyrexia-of-unknown-origin-and-assessment-of-interleukin-8-tumor-necrosis-factor-alpha-and-interferon-gamma-levels-in-scrub-typhus-positive-patients
#18
Meher Rizvi, Asfia Sultan, Madhav Chowdhry, Mohd Azam, Fatima Khan, Indu Shukla, Haris M Khan
Background: Scrub typhus is lesser known cause of fever of unknown origin in India. Even if there have been reports documenting the prevalence of scrub typhus in different parts of India, it is still an unknown entity, and clinicians usually do not consider it as differential diagnosis. The present study was performed to document the prevalence of scrub typhus among febrile patients in western part of Uttar Pradesh and to assess the clinical profile of infected patients on the one hand and knowledge, attitude, and practices among clinicians on the other...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29553921/rickettsial-illnesses-as-important-causes-of-febrile-illness-in-chittagong-bangladesh
#19
Hugh W Kingston, Mosharraf Hossain, Stije Leopold, Tippawan Anantatat, Ampai Tanganuchitcharnchai, Ipsita Sinha, Katherine Plewes, Richard J Maude, M A Hassan Chowdhury, Sujat Paul, Rabiul Alam Mohammed Erfan Uddin, Mohammed Abu Naser Siddiqui, Abu Shahed Zahed, Abdullah Abu Sayeed, Mohammed Habibur Rahman, Anupam Barua, Mohammed Jasim Uddin, Mohammed Abdus Sattar, Arjen M Dondorp, Stuart D Blacksell, Nicholas P J Day, Aniruddha Ghose, Amir Hossain, Daniel H Paris
We conducted a yearlong prospective study of febrile patients admitted to a tertiary referral hospital in Chittagong, Bangladesh, to assess the proportion of patients with rickettsial illnesses and identify the causative pathogens, strain genotypes, and associated seasonality patterns. We diagnosed scrub typhus in 16.8% (70/416) and murine typhus in 5.8% (24/416) of patients; 2 patients had infections attributable to undifferentiated Rickettsia spp. and 2 had DNA sequence-confirmed R. felis infection. Orientia tsutsugamushi genotypes included Karp, Gilliam, Kato, and TA763-like strains, with a prominence of Karp-like strains...
April 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29548879/development-of-a-rapid-and-visual-nucleotide-detection-method-towards-an-chinese-epidemic-strain-of-orientia-tsutsugamushi-based-on-recombinase-polymerase-amplification-assay-and-lateral-flow-test
#20
Yong Qi, Qiong Yin, Yinxiu Shao, Min Cao, Suqin Li, Hongxia Chen, Wanpeng Shen, Jixian Rao, Jiameng Li, Xiaoling Li, Yu Sun, Yu Lin, Yi Deng, Wenwen Zeng, Shulong Zheng, Suyun Liu, Yuexi Li
OBJECTIVES: Orientia tsutsugamushi is an obligate intracellular pathogen that causes scrub typhus. Diagnosing scrub typhus is still a challenge and sensitive, specific, simple, and rapid diagnostic tests is in need. METHODS: Recombinase polymerase amplification (RPA) assay combined with a lateral flow (LF) test was developed and optimized targeting 56-kDa gene of a Karp-like strain of O. tsutsugamushi. Detection limits, sensitivity, specificity, and simulative clinical performance were evaluated...
March 13, 2018: International Journal of Infectious Diseases: IJID
keyword
keyword
42302
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"