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Scrub typhus

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https://www.readbyqxmd.com/read/28088326/acute-kidney-injury-due-to-tropical-infectious-diseases-and-animal-venoms-a-tale-of-2-continents
#1
REVIEW
Emmanuel A Burdmann, Vivekanand Jha
South and Southeast Asia and Latin American together comprise 46 countries and are home to approximately 40% of the world population. The sociopolitical and economic heterogeneity, tropical climate, and malady transitions characteristic of the region strongly influence disease behavior and health care delivery. Acute kidney injury epidemiology mirrors these inequalities. In addition to hospital-acquired acute kidney injury in tertiary care centers, these countries face a large preventable burden of community-acquired acute kidney injury secondary to tropical infectious diseases or animal venoms, affecting previously healthy young individuals...
January 11, 2017: Kidney International
https://www.readbyqxmd.com/read/28086810/genotypic-characterization-of-orientia-tsutsugamushi-from-patients-in-two-geographical-locations-in-sri-lanka
#2
Ranjan Premaratna, Lucas S Blanton, Dilhar N Samaraweera, G Nalika N de Silva, Nilmini T G A Chandrasena, David H Walker, H J de Silva
BACKGROUND: To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to establish effective diagnostics, clinical management and to develop effective vaccines. Genetic and antigenic characterization of OT causing human disease in OT-endemic regions is not known for Sri Lanka...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056840/rapid-increase-of-scrub-typhus-incidence-in-guangzhou-southern-china-2006-2014
#3
Ye Sun, Yue-Hong Wei, Yang Yang, Yu Ma, Sake J de Vlas, Hong-Wu Yao, Yong Huang, Mai-Juan Ma, Kun Liu, Xiao-Ning Li, Xin-Lou Li, Wen-Hui Zhang, Li-Qun Fang, Zhi-Cong Yang, Wu-Chun Cao
BACKGROUND: In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. METHODS: Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identified environmental determinants for the spatial distribution of ST using a panel negative binomial model. RESULTS: A total of 4821 scrub typhus cases were reported in Guangzhou during 2006-2014...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056811/evaluation-of-a-broad-ranging-and-convenient-enzyme-linked-immunosorbent-assay-using-the-lysate-of-infected-cells-with-five-serotypes-of-orientia-tsutsugamushi-a-causative-agent-of-scrub-typhus
#4
Motohiko Ogawa, Masaaki Satoh, Masayuki Saijo, Shuji Ando
BACKGROUND: Scrub typhus is a mite-borne rickettsiosis caused by infection of Orientia tsutsugamushi, which is endemic to several Asia-Pacific Rim countries, including Japan. Although micro-indirect immunofluorescent assay (micro-IFA) is the standard method for the serological diagnosis of scrub typhus, enzyme-linked immunosorbent assay (ELISA) is considered to be more objective, by providing digitized results as opposed to being subject to the judgment of the evaluator as in micro-IFA...
January 5, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28055333/differences-in-clinical-and-laboratory-features-for-different-genotypes-of-orientia-tsutsugamushi-in-guangzhou-southern-china
#5
Yuehong Wei, Yu Ma, Lei Luo, Xinwei Wu, Yong Huang, Xiaoning Li, Zhicong Yang
PURPOSE: To describe the genotypes distribution of Orientia tsutsugamushi, in Guangzhou, and explore differences in clinical and laboratory features among genotypes. METHOD: We collected blood or eschar samples of all scrub typhus cases reported in 2013 from 10 district hospitals positive for PCR. We further tested the PCR-positive samples for DNA sequencing and phylogenetic analysis. We collected the demographic, clinical, and laboratory data by questionnaire and medical records...
January 5, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28050364/serological-diagnosis-of-acute-scrub-typhus-in-southern-india-evaluation-of-inbios-scrub-typhus-detect-igm-rapid-test-and-comparison-with-other-serological-tests
#6
Velmurugan Anitharaj, Selvaraj Stephen, Jothimani Pradeep, Sungman Park, Seung-Han Kim, Young Jin Kim, Eun-Ye Kim, Yoon-Won Kim
INTRODUCTION: Scrub Typhus (ST) is being reported from different parts of India in the recent past. However, the diagnosis and confirmation of ST cases require specific serological and molecular diagnostic tests. Both rapid and conventional ELISA tests need to be properly evaluated. AIM: Evaluation of a new ST IgM Immunochromatography (ICT) test kit (InBios Scrub Typhus Detect IgM Rapid Test) and compare it with another rapid kit, conventional ELISA kit and Weil-Felix (WF) test...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28044222/scrub-typhus-radiological-and-clinical-findings-in-abdominopelvic-involvement
#7
Kun Yung Kim, Ji Soo Song, Eun Hae Park, Gong Yong Jin
PURPOSE: To describe the clinical and radiological findings of abdominopelvic involvement in scrub typhus. MATERIALS AND METHODS: Abdominopelvic computed tomography (CT) of 78 patients with scrub typhus were evaluated by two readers. The presence of gallbladder wall thickening, arterial inhomogeneous enhancement of the liver, periportal edema, splenic infarction, hepatomegaly, splenomegaly, ascites, pleural effusion, and sites of lymphadenopathy were evaluated. Patients were divided into four clinical subgroups according to laboratory findings...
January 2, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27981627/characteristics-of-pediatric-scrub-typhus-eschar-in-south-indian-children
#8
Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Shanthi Ananthakrishnan
BACKGROUND: Knowledge of anatomic location of eschar is useful in diagnosing scrub typhus early in children and to initiate appropriate treatment. METHODS: All children younger than 12 years of age admitted with confirmed diagnosis of scrub typhus over a 17-month period were included and the presence of eschar and other characteristics were recorded and analyzed. RESULTS: Of 107 confirmed patients with scrub typhus, 37 (34.6%) presented with eschar...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27966835/the-epidemiology-and-characteristics-of-q-fever-and-co-infections-with-scrub-typhus-murine-typhus-or-leptospirosis-in-taiwan-a-nationwide-database-study
#9
C-H Lai, W Sun, C-H Lee, J-N Lin, M-H Liao, S-S Liu, T-Y Chang, K-F Tsai, Y-C Chang, H-H Lin, Y-H Chen
Q fever (QF) is a worldwide zoonosis associated with outbreaks. Only a few nationwide studies regarding the surveillance and epidemiology of human QF have been reported. Although QF is endemic in Taiwan, a nationwide database investigation of the epidemiology and characteristics of QF and its associations with scrub typhus (ST), murine typhus (MT) and leptospirosis (LS) has never been reported. We analysed nationwide databases of suspected QF, ST, MT and LS cases from October 2007 to December 2014 obtained from the Centers for Disease Control, Taiwan...
December 14, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27942194/acute-undifferentiated-febrile-illness-in-patients-presenting-to-a-tertiary-care-hospital-in-south-india-clinical-spectrum-and-outcome
#10
Kundavaram Paul Prabhakar Abhilash, Jonathan Arul Jeevan, Shubhanker Mitra, Nirvin Paul, Thimiri Palani Murugan, Ajay Rangaraj, Sandeep David, Samuel George Hansdak, John Antony Jude Prakash, Asha Mary Abraham, Prakash Ramasami, Sowmya Sathyendra, Thambu David Sudarsanam, George M Varghese
BACKGROUND: Acute undifferentiated febrile illness (AUFI) may have similar clinical presentation, and the etiology is varied and region specific. MATERIALS AND METHODS: This prospective observational study was conducted in a tertiary hospital in South India. All adult patients presenting with AUFI of 3-14 days duration were evaluated for etiology, and the differences in presentation and outcome were analyzed. RESULTS: The study cohort included 1258 patients...
October 2016: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/27928073/evolution-of-eschar-in-scrub-typhus
#11
Jin Park, Soo-Han Woo, Chang-Seop Lee
No abstract text is available yet for this article.
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27924792/a-cost-effective-approach-to-the-diagnosis-and-management-of-acute-infectious-encephalitis
#12
Usha Kant Misra, Vinita Elizabeth Mani, Jayantee Kalita
SETTING: A tertiary care teaching hospital in India. OBJECTIVE: To report a syndromic approach to acute encephalitis syndrome (AES) and propose a cost-effective model. STUDY DESIGN: AES patients were categorized by the presence or absence of myalgia/rash into systemic and neurological AES. The patients with systemic AES were investigated for dengue, scrub typhus, leptospira, chikungunya, and malaria, and those with neurological AES were investigated for herpes and Japanese encephalitis (JE)...
2017: European Neurology
https://www.readbyqxmd.com/read/27908651/eschar-a-stepping-stone-to-scrub-typhus
#13
Shu-Chao Weng, Hung-Chang Lee, Jeng-Jung Chen, Yu-Jyun Cheng, Hsin Chi, Chien-Yu Lin
No abstract text is available yet for this article.
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27887623/generation-of-protective-immunity-against-orientia-tsutsugamushi-infection-by-immunization-with-a-zinc-oxide-nanoparticle-combined-with-scaa-antigen
#14
Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim, Nam-Hyuk Cho
BACKGROUND: Zinc oxide nanoparticle (ZNP) has been applied in various biomedical fields. Here, we investigated the usage of ZNP as an antigen carrier for vaccine development by combining a high affinity peptide to ZNP. RESULTS: A novel zinc oxide-binding peptide (ZBP), FPYPGGDA, with high affinity to ZNP (K a  = 2.26 × 10(6) M(-1)) was isolated from a random peptide library and fused with a bacterial antigen, ScaA of Orientia tsutsugamushi, the causative agent of scrub typhus...
November 26, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27886863/analysis-of-scrub-typhus-involvement-of-the-lung-by-bronchoalveolar-lavage-a-case-report
#15
Shih-Yuan Lin, Yosuke Matsuno, Masahiro Yokosawa, Takeshi Suzuki, Yuko Morishima, Tohru Sakamoto, Takayuki Sumida, Nobuyuki Hizawa
No abstract text is available yet for this article.
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27885295/scrub-typhus-an-emerging-neglected-tropical-disease-in-nepal
#16
B P Upadhyaya, G Shakya, S Adhikari, N Rijal, J Acharya, L Maharjan, B R Marasini
BACKGROUND: Scrub typhus is a neglected tropical disease and is under reported from Nepal. The objective of this study was to investigate the sero-epidemiology of scrub typhus in patients suffering from acute febrile illness. METHODS: A total of 434 specimens collected from July to November 2015 at National Public Health Laboratory (NPHL) were investigated for detection of immunoglobulin M (IgM) antibody to Orientiatsutsugamushi.The Scrub Typhus Detect TM kit (InBios, USA) was used to detect the antibodies to O...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27883370/epstein-barr-virus-associated-hemophagocytic-syndrome-after-scrub-typhus-infection
#17
Jeong Woo Hong, Hyun Seon You, Tae Won Lee, Won Yong Jo, Bo Ra Kim, Young Sun Suh, In Gyu Bae, Oh Hyun Cho
There have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (HPS), most of which were treated successfully using adequate antibiotics. Here, we report a case of Epstein-Barr virus (EBV)-associated HPS after scrub typhus infection that was not improved using antirickettsial treatment. A 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-day doxycycline therapy...
December 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27834329/epidemiology-risk-factors-of-scrub-typhus-in-south-india
#18
George M Varghese, Deepa Raj, Mark R Francis, Rajiv Sarkar, Paul Trowbridge, Jayaprakash Muliyil
BACKGROUND & OBJECTIVES: Scrub typhus is a major public health threat in South and Southeastern Asian countries including India. Understanding local patterns of disease and factors that place individuals at risk is pivotal to future preventive measures against scrub typhus. The primary aim of this study was to identify specific epidemiological and geographical factors associated with an increased risk of developing scrub typhus in this region. METHODS: We mapped 709 patients from Tamil Nadu, Andhra Pradesh and Telangana who were admitted to the Christian Medical College (CMC) Hospital, Vellore, Tamil Nadu, India, for the period 2006-2011, assessed seasonality using monthly counts of scrub typhus cases, and conducted a case-control study among a subset of patients residing in Vellore...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27829876/scrub-typhus-in-pregnancy-maternal-and-fetal-outcomes
#19
Sudha J Rajan, Sowmya Sathyendra, Alice J Mathuram
Scrub typhus is an important unrecognized cause for undifferentiated acute febrile illness in India associated with poor fetal outcomes. Maternal and fetal outcomes among pregnant patients with scrub typhus presenting to a tertiary care university teaching hospital from January 2010 to July 2012 were studied. Scrub typhus was diagnosed by clinical criteria along with scrub ELISA positivity or an eschar. In total, 33 of 738 patients (4.5%) who were diagnosed with scrub typhus were pregnant; 57.6% were in the third trimester, 27...
December 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27790497/an-unusual-presentation-of-scrub-typhus
#20
Giridhar Reddy Banda, Srikrishna Raghavendra Boddu, Priyanka Ballal, Jayaprakash Belle
Presentation of scrub typhus associated with brachial neuritis is extremely rare with only a few cases reported so far. Here, we report a case of a 45-year-old female who presented with fever and right shoulder pain. Laboratory parameters showed leucocytosis with ELISA and PCR for scrub typhus positive. Electromyography (EMG) and Nerve Conduction Velocity (NCV) study was suggestive of brachial neuritis. She was given doxycycline therapy for 10 days following which her shoulder pain resolved.
September 2016: Journal of Clinical and Diagnostic Research: JCDR
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