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Scrub typhus

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https://www.readbyqxmd.com/read/28226202/predictors-of-acute-myocarditis-in-complicated-scrub-typhus-an-endemic-province-in-the-republic-of-korea
#1
Jung Yeon Chin, Ki-Woon Kang, Kyung Min Moon, Jongwoo Kim, Yu Jeong Choi
Background/Aims: Scrub typhus is known as a self-limited infectious disease. Cardiac complication is uncommon and usually not life-threatening. Until now, few cases of fulminant myocarditis by scrub typhus have been reported. So, we investigated incidence and predictors of acute myocarditis in severe scrub typhus. Methods: We retrospectively reviewed 89 patients among 91 scrub typhus confirmed patients who examined an echocardiogram and cardiac biomarkers from 2005 to 2015 in the intensive care unit at our hospital...
February 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28202789/use-of-multiplex-real-time-pcr-to-diagnose-scrub-typhus
#2
Wiwit Tantibhedhyangkul, Ekkarat Wongsawat, Saowaluk Silpasakorn, Duangdao Waywa, Nuttawut Saenyasiri, Jintapa Suesuay, Wilawan Thipmontree, Yupin Suputtamongkol
Scrub typhus, caused by Orientia tsutsugamushi, is a common cause of acute undifferentiated febrile illness in the Asia--Pacific region. However, its non-specific clinical manifestation often prevents early diagnosis. We propose the use of PCR and serologic tests as diagnostic tools. Here, we developed a multiplex real-time PCR assay using hydrolysis (Taqman) probes targeting O. tsutsugamushi47-kDa, groEL, and human IFNB genes to improve early diagnosis of scrub typhus. The amplification efficiency was higher than 94%, and the lower detection limit was 10 copies per reaction...
February 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28195095/molecular-detection-of-orientia-tsutsugamushi-from-suspected-scrub-typhus-cases
#3
Seethalakshmi Srinivasan, Thangam Menon
CONTEXT: Scrub typhus is an acute febrile illness caused by Orientia tsutsugamushi. The disease is under-diagnosed in India, because of low index of suspicion and also due to its nonspecific presentation, and lack of confirmatory diagnostic tests. AIMS: This study was undertaken to diagnose scrub typhus in patients with undifferentiated fevers by serology and molecular methods. MATERIALS AND METHODS: A total of 68 blood samples were collected from patients clinically suspected to have scrub typhus...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28193163/prevalence-and-clinical-presentation-of-rickettsia-coxiella-leptospira-bartonella-and-chikungunya-virus-infections-among-hospital-based-febrile-patients-from-december-2008-to-november-2009-in-bangladesh
#4
Labib Imran Faruque, Rashid Uz Zaman, Emily S Gurley, Robert F Massung, A S M Alamgir, Renee L Galloway, Ann M Powers, Ying Bai, Michael Kosoy, William L Nicholson, Mahmudur Rahman, Stephen P Luby
BACKGROUND: We conducted a study to identify Rickettsia, Coxiella, Leptospira, Bartonella, and Chikungunya virus infections among febrile patients presenting at hospitals in Bangladesh. METHODS: We collected blood samples from patients at six tertiary hospitals from December 2008 to November 2009 and performed laboratory tests at the United States Centers for Disease Control and Prevention (CDC). RESULTS: Out of 720 enrolled patients, 263 (37%) were infected with Rickettsia; 132 patients had immunofluorescence antibody titer >64 against spotted fever, 63 patients against scrub typhus fever and 10 patients against typhus fever...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28173608/prevalence-and-risk-factors-for-scrub-typhus-in-south-india
#5
Paul Trowbridge, P Divya, Prasanna S Premkumar, George M Varghese
OBJECTIVE: To determine the prevalence and risk factors of scub typhus in Tamil Nadu, South India. METHODS: We performed a clustered seroprevalence study of the areas around Vellore. All participants completed a risk factor survey, with seropositive and seronegative participants acting as cases and controls, respectively, in a risk factor analysis. After univariate analysis, variables found to be significant underwent multivariate analysis. RESULTS: Of 721 people participating in this study, 31...
February 7, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28149037/acute-respiratory-failure-in-scrub-typhus-patients
#6
Pradeep Marur Venkategowda, S Manimala Rao
No abstract text is available yet for this article.
December 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28144059/epidemiological-profile-of-acute-respiratory-distress-syndrome-patients-a-tertiary-care-experience
#7
Rahul Magazine, Shobitha Rao, Bharti Chogtu, Ramkumar Venkateswaran, Hameed Aboobackar Shahul, Umesh Goneppanavar
BACKGROUND: Acute respiratory distress syndrome (ARDS) is seen in critically ill patients. Its etiological spectrum in India is expected to be different from that seen in western countries due to the high prevalence of tropical infections. AIM: To study the epidemiological profile of ARDS patients. SETTING: A tertiary care hospital in Karnataka, India. MATERIALS AND METHODS: Retrospective analysis of 150 out of the 169 ARDS patients diagnosed during 2010-2012...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28122687/retrospective-survey-of-severe-fever-with-thrombocytopenia-syndrome-in-patients-with-suspected-rickettsiosis-in-japan
#8
Masaaki Satoh, Shintaro Akashi, Motohiko Ogawa, Takatoshi Wakeyama, Hiroshi Ogawa, Aiko Fukuma, Satoshi Taniguchi, Hideki Tani, Takeshi Kurosu, Shuetsu Fukushi, Masayuki Shimojima, Shuji Ando, Masayuki Saijo
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). The aim of this study was to clarify whether SFTS is potentially mis-diagnosed as rickettsioses, including spotted fever, typhus fever, and scrub typhus, which are also tick-borne disease. A total of 464 serum samples collected from 222 patients with clinically suspected rickettsiosis between 1999 and 2012 were tested for antibodies against the SFTSV. Of the 464 serum samples, one was positive for antibodies against the virus in an enzyme-linked immunosorbent assay and indirect immunofluorescence assay...
January 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28115665/successfully-managed-acute-transverse-myelitis-related-to-scrub-typhus-and-serial-image-findings
#9
Jae Sung Yun, Ji Soo Song, Eun Jung Choi, Jeong-Hwan Hwang, Chang-Seop Lee, Eun Hae Park
Central nervous system involvement manifesting as meningitis or meningoencephalitis is a known complication of scrub typhus, but very few spinal cord lesions such as acute transverse myelitis (ATM) have been reported in association with this disease. Scrub typhus patients with a spinal lesion present with neurologic symptoms including dysuria, motor, and sensory weakness. Herein, we describe a rare case of ATM associated with scrub typhus. Clinical characteristics, cerebrospinal fluid cytology, Orientia tsutsugamushi serum antibody titer, and serial magnetic resonance imaging scans resulted in a diagnosis of ATM associated with scrub typhus...
January 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28103630/orientia-tsutsugamushi-ank9-is-a-multifunctional-effector-that-utilizes-a-novel-grip-like-golgi-localization-domain-for-golgi-to-endoplasmic-reticulum-trafficking-and-interacts-with-host-copb2
#10
Andrea R Beyer, Kyle G Rodino, Lauren VieBrock, Ryan S Green, Brittney K Tegels, Lee D Oliver, Richard T Marconi, Jason A Carlyon
Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that afflicts one million people annually. This obligate intracellular bacterium boasts one of the largest microbial arsenals of ankyrin repeat-containing protein (Ank) effectors, most of which target the endoplasmic reticulum (ER) by undefined mechanisms. Ank9 is the only one proven to function during infection. Here, we demonstrate that Ank9 bears a motif that mimics the GRIP domain of eukaryotic golgins and is necessary and sufficient for its Golgi localization...
January 19, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28088326/acute-kidney-injury-due-to-tropical-infectious-diseases-and-animal-venoms-a-tale-of-2-continents
#11
REVIEW
Emmanuel A Burdmann, Vivekanand Jha
South and Southeast Asia and Latin American together comprise 46 countries and are home to approximately 40% of the world population. The sociopolitical and economic heterogeneity, tropical climate, and malady transitions characteristic of the region strongly influence disease behavior and health care delivery. Acute kidney injury epidemiology mirrors these inequalities. In addition to hospital-acquired acute kidney injury in tertiary care centers, these countries face a large preventable burden of community-acquired acute kidney injury secondary to tropical infectious diseases or animal venoms, affecting previously healthy young individuals...
January 11, 2017: Kidney International
https://www.readbyqxmd.com/read/28086810/genotypic-characterization-of-orientia-tsutsugamushi-from-patients-in-two-geographical-locations-in-sri-lanka
#12
Ranjan Premaratna, Lucas S Blanton, Dilhar N Samaraweera, G Nalika N de Silva, Nilmini T G A Chandrasena, David H Walker, H J de Silva
BACKGROUND: To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to establish effective diagnostics, clinical management and to develop effective vaccines. Genetic and antigenic characterization of OT causing human disease in OT-endemic regions is not known for Sri Lanka...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056840/rapid-increase-of-scrub-typhus-incidence-in-guangzhou-southern-china-2006-2014
#13
Ye Sun, Yue-Hong Wei, Yang Yang, Yu Ma, Sake J de Vlas, Hong-Wu Yao, Yong Huang, Mai-Juan Ma, Kun Liu, Xiao-Ning Li, Xin-Lou Li, Wen-Hui Zhang, Li-Qun Fang, Zhi-Cong Yang, Wu-Chun Cao
BACKGROUND: In the last decade, scrub typhus (ST) has been emerging or re-emerging in some areas of Asia, including Guangzhou, one of the most affected endemic areas of ST in China. METHODS: Based on the data on all cases reported in Guangzhou from 2006 to 2014, we characterized the epidemiological features, and identified environmental determinants for the spatial distribution of ST using a panel negative binomial model. RESULTS: A total of 4821 scrub typhus cases were reported in Guangzhou during 2006-2014...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056811/evaluation-of-a-broad-ranging-and-convenient-enzyme-linked-immunosorbent-assay-using-the-lysate-of-infected-cells-with-five-serotypes-of-orientia-tsutsugamushi-a-causative-agent-of-scrub-typhus
#14
Motohiko Ogawa, Masaaki Satoh, Masayuki Saijo, Shuji Ando
BACKGROUND: Scrub typhus is a mite-borne rickettsiosis caused by infection of Orientia tsutsugamushi, which is endemic to several Asia-Pacific Rim countries, including Japan. Although micro-indirect immunofluorescent assay (micro-IFA) is the standard method for the serological diagnosis of scrub typhus, enzyme-linked immunosorbent assay (ELISA) is considered to be more objective, by providing digitized results as opposed to being subject to the judgment of the evaluator as in micro-IFA...
January 5, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28055333/differences-in-clinical-and-laboratory-features-for-different-genotypes-of-orientia-tsutsugamushi-in-guangzhou-southern-china
#15
Yuehong Wei, Yu Ma, Lei Luo, Xinwei Wu, Yong Huang, Xiaoning Li, Zhicong Yang
PURPOSE: To describe the genotypes distribution of Orientia tsutsugamushi, in Guangzhou, and explore differences in clinical and laboratory features among genotypes. METHOD: We collected blood or eschar samples of all scrub typhus cases reported in 2013 from 10 district hospitals positive for PCR. We further tested the PCR-positive samples for DNA sequencing and phylogenetic analysis. We collected the demographic, clinical, and laboratory data by questionnaire and medical records...
January 5, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28050364/serological-diagnosis-of-acute-scrub-typhus-in-southern-india-evaluation-of-inbios-scrub-typhus-detect-igm-rapid-test-and-comparison-with-other-serological-tests
#16
Velmurugan Anitharaj, Selvaraj Stephen, Jothimani Pradeep, Sungman Park, Seung-Han Kim, Young Jin Kim, Eun-Ye Kim, Yoon-Won Kim
INTRODUCTION: Scrub Typhus (ST) is being reported from different parts of India in the recent past. However, the diagnosis and confirmation of ST cases require specific serological and molecular diagnostic tests. Both rapid and conventional ELISA tests need to be properly evaluated. AIM: Evaluation of a new ST IgM Immunochromatography (ICT) test kit (InBios Scrub Typhus Detect IgM Rapid Test) and compare it with another rapid kit, conventional ELISA kit and Weil-Felix (WF) test...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28044222/scrub-typhus-radiological-and-clinical-findings-in-abdominopelvic-involvement
#17
Kun Yung Kim, Ji Soo Song, Eun Hae Park, Gong Yong Jin
PURPOSE: To describe the clinical and radiological findings of abdominopelvic involvement in scrub typhus. MATERIALS AND METHODS: Abdominopelvic computed tomography (CT) of 78 patients with scrub typhus were evaluated by two readers. The presence of gallbladder wall thickening, arterial inhomogeneous enhancement of the liver, periportal edema, splenic infarction, hepatomegaly, splenomegaly, ascites, pleural effusion, and sites of lymphadenopathy were evaluated. Patients were divided into four clinical subgroups according to laboratory findings...
January 2, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/27981627/characteristics-of-pediatric-scrub-typhus-eschar-in-south-indian-children
#18
Thirunavukkarasu Arun Babu, Vijayasankar Vijayadevagaran, Shanthi Ananthakrishnan
BACKGROUND: Knowledge of anatomic location of eschar is useful in diagnosing scrub typhus early in children and to initiate appropriate treatment. METHODS: All children younger than 12 years of age admitted with confirmed diagnosis of scrub typhus over a 17-month period were included and the presence of eschar and other characteristics were recorded and analyzed. RESULTS: Of 107 confirmed patients with scrub typhus, 37 (34.6%) presented with eschar...
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27966835/the-epidemiology-and-characteristics-of-q-fever-and-co-infections-with-scrub-typhus-murine-typhus-or-leptospirosis-in-taiwan-a-nationwide-database-study
#19
C-H Lai, W Sun, C-H Lee, J-N Lin, M-H Liao, S-S Liu, T-Y Chang, K-F Tsai, Y-C Chang, H-H Lin, Y-H Chen
Q fever (QF) is a worldwide zoonosis associated with outbreaks. Only a few nationwide studies regarding the surveillance and epidemiology of human QF have been reported. Although QF is endemic in Taiwan, a nationwide database investigation of the epidemiology and characteristics of QF and its associations with scrub typhus (ST), murine typhus (MT) and leptospirosis (LS) has never been reported. We analysed nationwide databases of suspected QF, ST, MT and LS cases from October 2007 to December 2014 obtained from the Centers for Disease Control, Taiwan...
December 14, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27942194/acute-undifferentiated-febrile-illness-in-patients-presenting-to-a-tertiary-care-hospital-in-south-india-clinical-spectrum-and-outcome
#20
Kundavaram Paul Prabhakar Abhilash, Jonathan Arul Jeevan, Shubhanker Mitra, Nirvin Paul, Thimiri Palani Murugan, Ajay Rangaraj, Sandeep David, Samuel George Hansdak, John Antony Jude Prakash, Asha Mary Abraham, Prakash Ramasami, Sowmya Sathyendra, Thambu David Sudarsanam, George M Varghese
BACKGROUND: Acute undifferentiated febrile illness (AUFI) may have similar clinical presentation, and the etiology is varied and region specific. MATERIALS AND METHODS: This prospective observational study was conducted in a tertiary hospital in South India. All adult patients presenting with AUFI of 3-14 days duration were evaluated for etiology, and the differences in presentation and outcome were analyzed. RESULTS: The study cohort included 1258 patients...
October 2016: Journal of Global Infectious Diseases
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