James C Pino, Alexander L R Lubbock, Leonard A Harris, Danielle B Gutierrez, Melissa A Farrow, Nicole Muszynski, Tina Tsui, Stacy D Sherrod, Jeremy L Norris, John A McLean, Richard M Caprioli, John P Wikswo, Carlos F Lopez
Technological advances have made it feasible to collect multi-condition multi-omic time courses of cellular response to perturbation, but the complexity of these datasets impedes discovery due to challenges in data management, analysis, visualization, and interpretation. Here, we report a whole-cell mechanistic analysis of HL-60 cellular response to bendamustine. We integrate both enrichment and network analysis to show the progression of DNA damage and programmed cell death over time in molecular, pathway, and process-level detail using an interactive analysis framework for multi-omics data...
November 18, 2022: IScience