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https://www.readbyqxmd.com/read/29675141/differential-hypomethylation-of-the-repetitive-tol2-alu-rich-sequences-in-the-genome-of-bodianus-species-labriformes-labridae
#1
Clóvis C Motta-Neto, André Marques, Gideão W W F Costa, Marcelo B Cioffi, Luiz A C Bertollo, Rodrigo X Soares, Kátia C Scortecci, Roberto F Artoni, Wagner F Molina
Representatives of the order Labriformes show karyotypes of extreme conservatism together with others with high chromosomal diversification. However, the cytological characterization of epigenetic modifications remains unknown for the majority of the species. In the family Labridae, the most abundant fishes on tropical reefs, the genomes of the genus Bodianus Bloch, 1790 have been characterized by the occurrence of a peculiar chromosomal region, here denominated BOD. This region is exceptionally decondensed, heterochromatic, argentophilic, GC-neutral and, in contrast to classical secondary constrictions, shows no signals of hybridization with 18S rDNA probes...
2018: Comparative Cytogenetics
https://www.readbyqxmd.com/read/29405092/a-porcine-model-of-skin-wound-infected-with-a-polybacterial-biofilm
#2
Pavel Klein, Martin Sojka, Jan Kucera, Jana Matonohova, Vojtech Pavlik, Jan Nemec, Gabriela Kubickova, Rastislav Slavkovsky, Katarzyna Szuszkiewicz, Petr Danek, Miroslav Rozkot, Vladimir Velebny
A clinically relevant porcine model of a biofilm-infected wound was established in 10 minipigs. The wounds of six experimental animals were infected with a modified polymicrobial Lubbock chronic wound biofilm consisting of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Bacillus subtilis. Four animals served as uninfected controls. The wounds were monitored until they had healed for 24 days. The biofilm persisted in the wounds up to day 14 and significantly affected healing. The control to infected healed wound area ratios were: 45%/21%, 66%/37%, and 90%/57% on days 7, 10 and 14, respectively...
February 2018: Biofouling
https://www.readbyqxmd.com/read/29245701/-i-pseudanthias-i-i-tequila-i-a-new-species-of-anthiadine-serranid-from-the-ogasawara-and-mariana-islands
#3
Anthony C Gill, Yi-Kai Tea, Hiroshi Senou
Pseudanthias tequila is described on the basis of two specimens from the Ogasawara Islands. It also is recorded from the Mariana Islands on the basis of colour photographs. The species belongs to a complex that includes P. randalli (Lubbock & Allen), P. pulcherrimus Heemstra & Randall, P. flavicauda Randall & Pyle, P. oumati Williams, Delrieu-Trottin & Planes, and a potentially new species from the Line Islands. Species within the complex are distinguished on the basis of male live colouration, morphometric details and gill-raker and scale counts...
October 30, 2017: Zootaxa
https://www.readbyqxmd.com/read/29176098/incidence-of-non-melanoma-skin-cancer-in-the-uninsured
#4
Ashley Sturgeon, David Allen Pate, Ravi Patel, Katherine Snodgrass, Michelle Tarbox, Fiona Prabhu, Phillip Watkins
Non-melanoma skin cancer (NMSC) is a common reason for outpatient primary care visits. Uninsured patients may be at a higher risk for NMSC due to lack of access to health care and a possible increased risk of sun exposure due to insecure housing. The true incidence of NMSC in this population is unknown. In order to determine the population's incidence of NMSC we performed a retrospective chart review on all patients (n = 656) seen at the Lubbock Impact Free Clinic from July 1, 2014 through July 30, 2015. This highlighted an increased incidence of NMSC in our uninsured population (1...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/29168249/violent-crime-redistribution-in-a-city-following-a-substantial-increase-in-the-number-of-off-sale-alcohol-outlets-a-bayesian-analysis
#5
Dennis M Gorman, William R Ponicki, Qi Zheng, Daikwon Han, Paul J Gruenewald, Andrew J Gaidus
INTRODUCTION AND AIMS: This study examined whether the introduction of a large number of off-premise alcohol outlets into a city over a brief period of time could affect rates of violent crime. DESIGN AND METHODS: The study analysed annual counts of violent crime across 172 US Census block groups in Lubbock, Texas from 2006 through 2011. Spatial Poisson models related annual violent crime counts within each block group to off-premise and on-premise alcohol outlets active during this time period as well as neighbourhood socio-demographic characteristics...
November 22, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29154790/recognition-of-rare-hemoglobin-variants-by-hemoglobin-a-1c-measurement-procedures
#6
Sydney W Strickland, Sean T Campbell, Randie R Little, David E Bruns, Lindsay A L Bazydlo
BACKGROUND: Unrecognized hemoglobinopathies can lead to measured hemoglobin A1c (Hb A1c ) concentrations that are erroneous or misleading. We determined the effects of rare hemoglobin variants on capillary electrophoresis (CE) and HPLC methods for measurement of Hb A1c . METHODS: We prospectively investigated samples in which Hb A1c was measured by CE during a 14-month period. For samples in which the electropherograms suggested the presence of rare hemoglobinopathies, hemoglobin variants were identified by molecular analysis or by comparison with electropherograms of known variants...
January 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29064859/increasing-the-accessibility-of-sexual-assault-forensic-examinations-evaluation-of-texas-law-sb-1191
#7
Robert C Davis, Bernard Auchter, Susan Howley, Torie Camp, Ilse Knecht, William Wells
INTRODUCTION: Texas SB 1191 was enacted in 2013 with the intent of increasing access to medical forensic examinations for sexual assault victims by requiring every hospital with an emergency department to be prepared to provide a medical forensic examination if requested by a sexual assault victim. To realize that goal, the law also required basic forensic training for medical professionals before conducting a medical forensic examination as well as a requirement that hospitals develop a "plan to train personnel on sexual assault forensic evidence collection...
October 2017: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/28666314/gpu-powered-model-analysis-with-pysb-cupsoda
#8
Leonard A Harris, Marco S Nobile, James C Pino, Alexander L R Lubbock, Daniela Besozzi, Giancarlo Mauri, Paolo Cazzaniga, Carlos F Lopez
Summary: A major barrier to the practical utilization of large, complex models of biochemical systems is the lack of open-source computational tools to evaluate model behaviors over high-dimensional parameter spaces. This is due to the high computational expense of performing thousands to millions of model simulations required for statistical analysis. To address this need, we have implemented a user-friendly interface between cupSODA, a GPU-powered kinetic simulator, and PySB, a Python-based modeling and simulation framework...
November 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28665906/characteristics-of-patients-with-congestive-heart-failure-or-chronic-obstructive-pulmonary-disease-readmissions-within-30-days-following-an-acute-exacerbation
#9
Austin Castillo, Hawa Edriss, Kavitha Selvan, Kenneth Nugent
BACKGROUND: The Hospital Readmissions Reduction Program targets Medicare patients with congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) and penalizes hospitals that have increased 30-day readmission rates for these patients. The main goals of this study were to determine the clinical explanations for readmissions within 30 days, to identify possible deficiencies in patient care, and to identify typical characteristics of patients who were readmitted to the hospital...
July 2017: Quality Management in Health Care
https://www.readbyqxmd.com/read/28648142/overcoming-intratumoural-heterogeneity-for-reproducible-molecular-risk-stratification-a-case-study-in-advanced-kidney-cancer
#10
Alexander L R Lubbock, Grant D Stewart, Fiach C O'Mahony, Alexander Laird, Peter Mullen, Marie O'Donnell, Thomas Powles, David J Harrison, Ian M Overton
BACKGROUND: Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for prediction of response to treatment. Considerable investment in molecular risk stratification has sought to overcome the performance ceiling encountered by methods restricted to traditional clinical parameters. However, replication of results has proven challenging, and intratumoural heterogeneity (ITH) may confound attempts at tissue-based stratification...
June 26, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28630809/technical-report-of-the-use-of-a-novel-eye-tracking-system-to-measure-impairment-associated-with-mild-traumatic-brain-injury
#11
Michael Kelly
This technical report details the results of an uncontrolled study of EyeGuide Focus, a 10-second concussion management tool which relies on eye tracking to determine the potential impairment of visual attention, an indicator often of mild traumatic brain injury (mTBI). Essentially, people who can visually keep steady and accurate attention on a moving object in their environment likely suffer from no impairment. However, if after a potential mTBI event, subjects cannot keep attention on a moving object in a normal way as demonstrated on their previous healthy baseline tests...
May 15, 2017: Curēus
https://www.readbyqxmd.com/read/28513291/low-cost-mobile-air-pollution-monitoring-in-urban-environments-a-pilot-study-in-lubbock-texas
#12
Grant R McKercher, Jennifer K Vanos
The complex nature of air pollution in urban areas prevents traditional monitoring techniques from obtaining measurements representative of true human exposure. The current study assessed the capability of low-cost mobile monitors to acquire useful data in a city without a monitoring network in place (Lubbock, Texas) using a bicycle platform. The monitoring campaign resulted in 30 days of data along a 13.4 km fixed concentric route. Due to high sensitivities to airflow, the apparent wind velocity was accounted for throughout the route...
June 5, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28477222/the-influence-of-surface-type-on-the-absorbed-radiation-by-a-human-under-hot-dry-conditions
#13
A W Hardin, J K Vanos
Given the predominant use of heat-retaining materials in urban areas, numerous studies have addressed the urban heat island mitigation potential of various "cool" options, such as vegetation and high-albedo surfaces. The influence of altered radiational properties of such surfaces affects not only the air temperature within a microclimate, but more importantly the interactions of long- and short-wave radiation fluxes with the human body. Minimal studies have assessed how cool surfaces affect thermal comfort via changes in absorbed radiation by a human (Rabs ) using real-world, rather than modeled, urban field data...
January 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28456735/aneurysms-of-the-proximal-segment-of-the-anterior-cerebral-artery-a-new-classification-system-with-corresponding-therapeutic-options
#14
Xinmin Ding, Peyton L Nisson, Whitney S James, Michael T Lawton, Shaohua Ren, Lu Jia, Honging Ji
OBJECTIVE: This study aims to establish a new classification system for proximal anterior cerebral artery (A1) aneurysms and to offer treatment strategies, based on the lessons learned by studying the case reports of 41 patients with A1 aneurysms. METHODS: A total of 2332 consecutive patients with intracranial aneurysms were treated at a single medical center between June 2005 and May 2015. Forty-one patients with 42 A1 aneurysms were treated by surgical clipping or endovascular coiling...
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28440932/microplastics-in-a-freshwater-environment-receiving-treated-wastewater-effluent
#15
Steven Lasee, Jessica Mauricio, William A Thompson, Adcharee Karnjanapiboonwong, John Kasumba, Seenivasan Subbiah, Audra N Morse, Todd A Anderson
Small plastic fragments (microplastics or solid particles <5 mm in size or "microbeads" used in personal care products and cosmetics) may ultimately find their way into aquatic environments. We studied the presence of microplastics (particle sizes 53-105 μm and 106-179 μm) spatially and temporally in 3 connected urban lakes being fed by treated wastewater effluent in Lubbock, Texas. These lakes also serve as drainage during storm events. Water samples from drainage playa wetlands within the city were also collected...
May 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28097673/schoolyard-shade-and-sun-exposure-assessment-of-personal-monitoring-during-children-s-physical-activity
#16
Jennifer K Vanos, Grant R McKercher, Kylie Naughton, Marc Lochbaum
Childhood exposure to ultraviolet radiation (UVR) is a major risk factor for the development of melanoma later in life. However, it is challenging to accurately determine personal outdoor exposure to UVR, specifically erythemally weighted UVR (UVEry ), due to technological constraints, variable time-activity patterns, and the influence of outdoor environmental design. To address this challenge, this study utilized mobile and stationary techniques to examine the UVEry exposures of 14 children in a schoolyard in Lubbock, TX, in spring 2016...
July 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28088864/integrated-high-throughput-multiomics-platform-enables-data-driven-construction-of-cellular-responses-and-reveals-global-drug-mechanisms-of-action
#17
Jeremy L Norris, Melissa A Farrow, Danielle B Gutierrez, Lauren D Palmer, Nicole Muszynski, Stacy D Sherrod, James C Pino, Jamie L Allen, Jeffrey M Spraggins, Alex L R Lubbock, Ashley Jordan, William Burns, James C Poland, Carrie Romer, M Lisa Manier, Yuan-Wei Nei, Boone M Prentice, Kristie L Rose, Salisha Hill, Raf Van de Plas, Tina Tsui, Nathaniel M Braman, M Ray Keller, Stacey A Rutherford, Nichole Lobdell, Carlos F Lopez, D Borden Lacy, John A McLean, John P Wikswo, Eric P Skaar, Richard M Caprioli
An understanding of how cells respond to perturbation is essential for biological applications; however, most approaches for profiling cellular response are limited in scope to pre-established targets. Global analysis of molecular mechanism will advance our understanding of the complex networks constituting cellular perturbation and lead to advancements in areas, such as infectious disease pathogenesis, developmental biology, pathophysiology, pharmacology, and toxicology. We have developed a high-throughput multiomics platform for comprehensive, de novo characterization of cellular mechanisms of action...
March 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/27959871/seasonal-influence-of-environmental-variables-and-artificial-aeration-on-escherichia-coli-in-small-urban-lakes
#18
Bart W Durham, Lucy Porter, Allie Webb, Joshua Thomas
This study investigated patterns of Escherichia coli in urban lakes in Lubbock, Texas. Specific objectives were to (1) document seasonal patterns in abundance of E. coli over a 3-year period, (2) identify environmental factors, including effects of migratory geese and artificial aeration devices that may influence E. coli abundance, and (3) determine if E. coli abundance over time was similar for individual lakes. Water samples were collected monthly for 36 months from six lakes, three of which contained artificial aeration devices (fountains)...
December 2016: Journal of Water and Health
https://www.readbyqxmd.com/read/27774359/technical-report-of-successful-deployment-of-tandem-visual-tracking-during-live-laparoscopic-cholecystectomy-between-novice-and-expert-surgeon
#19
Yana Puckett, Benedicto C Baronia
With the recent advances in eye tracking technology, it is now possible to track surgeons' eye movements while engaged in a surgical task or when surgical residents practice their surgical skills. Several studies have compared eye movements of surgical experts and novices and developed techniques to assess surgical skill on the basis of eye movement utilizing simulators and live surgery. None have evaluated simultaneous visual tracking between an expert and a novice during live surgery. Here, we describe a successful simultaneous deployment of visual tracking of an expert and a novice during live laparoscopic cholecystectomy...
September 20, 2016: Curēus
https://www.readbyqxmd.com/read/27391147/a-blind-test-of-the-younger-dryas-impact-hypothesis
#20
Vance Holliday, Todd Surovell, Eileen Johnson
The Younger Dryas Impact Hypothesis (YDIH) states that North America was devastated by some sort of extraterrestrial event ~12,800 calendar years before present. Two fundamental questions persist in the debate over the YDIH: Can the results of analyses for purported impact indicators be reproduced? And are the indicators unique to the lower YD boundary (YDB), i.e., ~12.8k cal yrs BP? A test reported here presents the results of analyses that address these questions. Two different labs analyzed identical splits of samples collected at, above, and below the ~12...
2016: PloS One
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