Miruto Tanaka, Shinsuke Nakamura, Tomohisa Sakaue, Takumi Yamamoto, Masashi Maekawa, Anri Nishinaka, Hiroto Yasuda, Kaori Yunoki, Yuji Sato, Masaaki Sawa, Kohichiro Yoshino, Masamitsu Shimazawa, Masahiko Hatano, Takeshi Tokuhisa, Shigeki Higashiyama, Hideaki Hara
BACKGROUND: Endothelial cell activation is tightly controlled by the balance between VEGF (vascular endothelial cell growth factor) and Notch signaling pathway. VEGF destabilizes blood vessels and promotes neovascularization, which are common features of sight-threatening ocular vascular disorders. Here, we show that BCL6B (B-cell CLL/lymphoma 6 member B protein), also known as BAZF, ZBTB28, and ZNF62, plays a pivotal role in the development of retinal edema and neovascularization. METHODS: The pathophysiological physiological role of BCL6B was investigated in cellular and animal models mimicking 2 pathological conditions: retinal vein occlusion and choroidal neovascularization...
June 2023: Arteriosclerosis, Thrombosis, and Vascular Biology