Xiurong Ma, Junjian Lu, Peixin Yang, Zheng Zhang, Bo Huang, Rongtao Li, Ruirong Ye
As an ideal scaffold for metal ion chelation, 8-hydroxyquinoline (8HQ) can chelate different metal ions, such as Fe2+ , Cu2+ , Zn2+ , etc. Here, by integrating 8HQ with a ruthenium(II) polypyridyl moiety, two Ru(II)-8HQ complexes (Ru1 and Ru2), [Ru(N-N)2 L](PF6 )2 (L = 2-(1 H -imidazo[4,5- f ][1,10]phenanthrolin-2-yl)quinolin-8-ol; N-N: 2,2'-bipyridine (bpy, in Ru1), 1,10-phenanthroline (phen, in Ru2)) were designed and synthesized. In both complexes, ligand L is an 8HQ derivative designed to chelate the cofactor Fe2+ of jumonji C domain-containing demethylase (JMJD)...
August 30, 2022: Dalton Transactions: An International Journal of Inorganic Chemistry