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JOURNAL ARTICLE
Gregory W Roloff, Satyajit Kosuri, Mariam T Nawas, Adam S DuVall, Anand A Patel, Peter A Riedell, Olatoyosi Odenike, Wendy Stock, Richard A Larson, Michael R Bishop, Emma Nunley, Lucy A Godley, Feighanne Hathaway, Daniela Del Gaudio, Soma Das, Lorraine E Canham, Michael W Drazer
Not available.
April 11, 2024: Haematologica
#22
Luke Lambourne, Kaia Mattioli, Clarissa Santoso, Gloria Sheynkman, Sachi Inukai, Babita Kaundal, Anna Berenson, Kerstin Spirohn-Fitzgerald, Anukana Bhattacharjee, Elisabeth Rothman, Shaleen Shrestha, Florent Laval, Zhipeng Yang, Deepa Bisht, Jared A Sewell, Guangyuan Li, Anisa Prasad, Sabrina Phanor, Ryan Lane, Devlin M Campbell, Toby Hunt, Dawit Balcha, Marinella Gebbia, Jean-Claude Twizere, Tong Hao, Adam Frankish, Josh A Riback, Nathan Salomonis, Michael A Calderwood, David E Hill, Nidhi Sahni, Marc Vidal, Martha L Bulyk, Juan I Fuxman Bass
Most human Transcription factors (TFs) genes encode multiple protein isoforms differing in DNA binding domains, effector domains, or other protein regions. The global extent to which this results in functional differences between isoforms remains unknown. Here, we systematically compared 693 isoforms of 246 TF genes, assessing DNA binding, protein binding, transcriptional activation, subcellular localization, and condensate formation. Relative to reference isoforms, two-thirds of alternative TF isoforms exhibit differences in one or more molecular activities, which often could not be predicted from sequence...
April 10, 2024: bioRxiv
#23
JOURNAL ARTICLE
Adam M Gordon, Mitchell K Ng, Faisal Elali, Nicolas S Piuzzi, Michael A Mont
INTRODUCTION: Socioeconomic status (SES) has been demonstrated to be an important prognostic risk factor among patients undergoing total joint arthroplasty. We evaluated patients living near neighborhoods with higher socioeconomic risk undergoing total knee arthroplasty (TKA) and if they were associated with differences in: 1) medical complications; 2) emergency department (ED) utilizations; 3) readmissions; and 4) costs of care. METHODS: A query of a national database from 2010 to 2020 was performed for primary TKAs...
April 12, 2024: Journal of Arthroplasty
#24
JOURNAL ARTICLE
Rajish Shil, Cordelia Dunai, Adam Seed, Greta Wood, Ceryce Collie, Sophie Pendered, Michael Bonello, Liene Elsone, Benedict Michael
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#25
JOURNAL ARTICLE
Laura Breen, James Flynn, Adam Bergin, Evangelia Flampouri, Michael Butler
Reliable monitoring of mammalian cells in bioreactors is essential to biopharmaceutical production. Trypan blue exclusion is a method of determining cell density and viability that has been used for over one hundred years to monitor cells in culture and is the current standard method in biomanufacturing. This method has many disadvantages however and there is a growing demand for more detailed and in-line measurements of cell growth in bioreactors. This article assesses a novel dynamic imaging system for single cell analysis...
April 13, 2024: Biotechnology Progress
#26
REVIEW
Milou Berends, Hans L A Nienhuis, David Adams, Chafic Karam, Marco Luigetti, Michael Polydefkis, Mary M Reilly, Yoshiki Sekijima, Bouke P C Hazenberg
Peripheral and autonomic neuropathy are common disease manifestations in systemic amyloidosis. The neurofilament light chain (NfL), a neuron-specific biomarker, is released into the blood and cerebrospinal fluid after neuronal damage. There is a need for an early and sensitive blood biomarker for polyneuropathy, and this systematic review provides an overview on the value of NfL in the early detection of neuropathy, central nervous system involvement, the monitoring of neuropathy progression, and treatment effects in systemic amyloidosis...
March 28, 2024: International Journal of Molecular Sciences
#27
JOURNAL ARTICLE
Arietta Spinou, Beatriz Hererro-Cortina, Stefano Aliberti, Pieter C Goeminne, Eva Polverino, Katerina Dimakou, Charles S Haworth, Michael R Loebinger, Anthony De Soyza, Montserrat Vendrell, Pierre Regis Burgel, Melissa McDonnell, Sivagurunathan Sutharsan, Sabina Skrgat, Luiz Maiz-Carro, Oriol Sibila, Daiana Stolz, Paula Kauppi, Apostolos Bossios, Adam T Hill, Ian Clifton, Megan L Crichton, Paul Walker, Rosario Menendez, Sermin Borecki, Dusanka Obradovic, Adam Nowinski, Adelina Amorim, Antoni Torres, Natalie Lorent, Tobias Welte, Francesco Blasi, Mateja Jankovic Makek, Michal Shteinberg, Wim Boersma, J Stuart Elborn, James D Chalmers, Felix C Ringshausen
BACKGROUND: International guidelines recommend airway clearance management as one of the important pillars of bronchiectasis treatment. However, the extent to which airway clearance is used for people with bronchiectasis in Europe is unclear. The aim of the study was to identify the use of airway clearance management in patients with bronchiectasis across different countries and factors influencing airway clearance use. METHODS: Prospective observational study using data from the EMBARC Registry between January 2015 and April 2022...
April 12, 2024: European Respiratory Journal
#28
JOURNAL ARTICLE
Stefano Aliberti, Felix C Ringshausen, Raja Dhar, Charles S Haworth, Michael R Loebinger, Katerina Dimakou, Megan L Crichton, Anthony De Soyza, Montse Vendrell, Pierre-Regis Burgel, Melissa McDonnell, Sabina Skrgat, Luis Maiz Carro, Andres de Roux, Oriol Sibila, Apostolos Bossios, Menno van der Eerden, Paula Kauppi, Robert Wilson, Branislava Milenkovic, Rosario Menendez, Marlene Murris, Sermin Borekci, Oxana Munteanu, Dusanka Obradovic, Adam Nowinski, Adelina Amorim, Antoni Torres, Natalie Lorent, Eva Van Braeckel, Josje Altenburg, Amelia Shoemark, Michal Shteinberg, Wim Boersma, Pieter C Goeminne, J Stuart Elborn, Adam T Hill, Tobias Welte, Francesco Blasi, Eva Polverino, James D Chalmers
INTRODUCTION: A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In the EMBARC registry, we tested whether sputum colour would be associated with disease severity and clinical outcomes. METHODS: Prospective, observational registry of adults with bronchiectasis conducted in 31 countries. Patients who did not produce spontaneous sputum were excluded from the analysis. The Murray sputum colour chart was used at baseline and at follow-up visits...
April 12, 2024: European Respiratory Journal
#29
JOURNAL ARTICLE
Emmanuel Aniekan Essien, Bonaventure Michael Ukoaka, Faithful Miebaka Daniel, Gideon Okobru, Tajuddeen Wali Adam
Mistreatment in medical education encompasses various forms of abusive behavior, often indicating a disregard for students' dignity and interfering with the learning process. This review paper aims to investigate the prevalence, patterns, and correlates of medical student mistreatment in Nigerian medical education and shed light on its impact on students' well-being. A literature search was conducted in August 2023 using Medline, Google Scholar, and Web of Science databases to identify relevant studies on the mistreatment of Nigerian medical students...
April 12, 2024: Medicine (Baltimore)
#30
JOURNAL ARTICLE
Hamid Al Badi, Michael Tanzer, Robert Turcotte, Adam Hart
CASE: A 38-year-old man with congenital pain insensitivity underwent bilateral below-knee amputations. After his subsequent bilateral osseointegration (OI) limb replacements, he rapidly developed severe bilateral knee arthritis and varus deformity. In lieu of performing bilateral above-knee amputations, he underwent bilateral staged total knee arthroplasties (TKA) with excellent clinical and radiographic evaluation at 1-year follow-up. CONCLUSION: To address both the limited bone stock and OI implant stem location, TKA after OI limb replacement in congenital pain insensitivity patients can be successfully achieved with a nonkeeled cementless tibial component and augmentation with a tibial cone...
April 1, 2024: JBJS Case Connector
#31
JOURNAL ARTICLE
Adam D Price, Ryan C Chae, Taylor E Wallen, Ellen R Becker, Matthew R Baucom, Rebecca Schuster, Lisa England, Timothy A Pritts, Michael D Goodman
BACKGROUND: Prior literature has implicated Red Blood Cells (RBCs) in the initiation of thrombosis and suggests that post-transfusion hypercoagulability may occur secondary to the effects of RBCs. Elevated serum tissue factor is a known sequelae of acute trauma. Phosphatidylserine is a pro-thrombotic phospholipid present within the RBC cell membrane. We hypothesized that RBC aggregation is dependent on the interaction between RBC membrane bound (exposed) PS, extracellular calcium, and tissue factor...
April 12, 2024: Journal of Trauma and Acute Care Surgery
#32
JOURNAL ARTICLE
Megan Polden, Andrew Jones, Michael Essman, Jean Adams, Tom Bishop, Thomas Burgoine, Aisling Donohue, Stephen Sharp, Martin White, Richard Smith, Eric Robinson
BACKGROUND AND OBJECTIVES: On 6 April 2022, the UK government implemented mandatory kilocalorie (kcal) labelling regulations for food and drink products sold in the out-of-home food sector (OHFS) in England. Previous assessments of kcal labelling practices in the UK OHFS found a low prevalence of voluntary implementation and poor compliance with labelling recommendations. This study aimed to examine changes in labelling practices preimplementation versus post implementation of mandatory labelling regulations in 2022...
April 11, 2024: BMJ Open
#33
JOURNAL ARTICLE
Aashi Parikh, Johan Pansu, Adam Stow, Michael St J Warne, Christine Chivas, Paul Greenfield, Frédéric Boyer, Stuart Simpson, Rachael Smith, Jacob Gruythuysen, Geoffrey Carlin, Natalie Caulfield, Frédérique Viard, Anthony A Chariton
Agricultural run-off in Australia's Mackay-Whitsunday region is a major source of nutrient and pesticide pollution to coastal and inshore ecosystems of the Great Barrier Reef. While the effects of run-off are well documented for the region's coral and seagrass habitats, the ecological impacts on estuaries, the direct recipients of run-off, are less known. This is particularly true for fish communities, which are shaped by the physico-chemical properties of coastal waterways that vary greatly in tropical regions...
April 9, 2024: Environmental Pollution
#34
JOURNAL ARTICLE
Adam G Culvenor, Thomas J West, Andrea M Bruder, Mark J Scholes, Christian J Barton, Ewa M Roos, Edwin H G Oei, Steven M McPhail, Richard B Souza, Jusuk Lee, Brooke E Patterson, Michael A Girdwood, Jamon L Couch, Kay M Crossley
OBJECTIVES: The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of individuals needed to be screened to include one participant (NNS) and (3) report baseline characteristics of randomised participants. METHODS: The SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER)-Knee RCT compares SUPER and minimal intervention for young adults (aged 18-40 years) with ongoing symptoms (ie, mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score subscales (KOOS4 )) 9-36 months post-ACLR...
2024: BMJ Open Sport & Exercise Medicine
#35
JOURNAL ARTICLE
Philipp Lurz, Thomas Schmitz, Tobias Geisler, Jörg Hausleiter, Ingo Eitel, Volker Rudolph, Edith Lubos, Ralph Stephan von Bardeleben, Nedy Brambilla, Federico De Marco, Sergio Berti, Holger Nef, Axel Linke, Christian Hengstenberg, Stephan Baldus, Konstantinos Spargias, Paolo Denti, Georg Nickenig, Helge Möllmann, Wolfgang Rottbauer, Fabien Praz, Christian Butter, Markus Reinthaler, Nicolas M Van Mieghem, Mohammad Sherif, Martin Swaans, Adam Witkowski, Mamta Buch, Tim Seidler, Andrés Iñiguez, Holger Thiele, Mareike Eißmann, Juergen Schreieck, Michael Näbauer, Leo Marcoff, Konstantinos Koulogiannis, Tienush Rassaf, Peter Luedike
BACKGROUND: Mitral transcatheter edge-to-edge repair (M-TEER) is a guideline-recommended treatment option for patients with severe symptomatic mitral regurgitation (MR). Outcomes with the PASCAL system in a post-market setting have not been established. OBJECTIVES: The authors report 30-day and 1-year outcomes from the MiCLASP (Transcatheter Repair of Mitral Regurgitation with Edwards PASCAL Transcatheter Valve Repair System) European post-market clinical follow-up study...
April 8, 2024: JACC. Cardiovascular Interventions
#36
JOURNAL ARTICLE
Sigrid V Carlsson, Mark Preston, Andrew Vickers, Deepak Malhotra, Behfar Ehdaie, Michael Healey, Adam S Kibel
OBJECTIVES: We conducted a focus group to assess the attitudes of primary care physicians (PCPs) toward prostate-specific antigen (PSA)-screening algorithms, perceptions of using decision support tools, and features that would make such tools feasible to implement. METHODS: A multidisciplinary team (primary care, urology, behavioral sciences, bioinformatics) developed the decision support tool that was presented to a focus group of 10 PCPs who also filled out a survey...
March 2024: Applied Clinical Informatics
#37
JOURNAL ARTICLE
Sigrid V Carlsson, Mark A Preston, Andrew Vickers, Deepak Malhotra, Behfar Ehdaie, Michael J Healey, Adam S Kibel
OBJECTIVES: Our objective was to pilot test an electronic health record-embedded decision support tool to facilitate prostate-specific antigen (PSA) screening discussions in the primary care setting. METHODS: We pilot-tested a novel decision support tool that was used by 10 primary care physicians (PCPs) for 6 months, followed by a survey. The tool comprised (1) a risk-stratified algorithm, (2) a tool for facilitating shared decision-making (Simple Schema), (3) three best practice advisories (BPAs: <45, 45-75, and >75 years), and (4) a health maintenance module for scheduling automated reminders about PSA rescreening...
March 2024: Applied Clinical Informatics
#38
JOURNAL ARTICLE
Satoshi Shoji, Lisa A Kaltenbach, Bradi B Granger, Gregg C Fonarow, Hussein Al-Khalidi, Nancy M Albert, Javed Butler, Larry A Allen, G Michael Felker, Robert W Harrison, Marat Fudim, Adam J Nelson, Christopher B Granger, Adrian F Hernandez, Adam D DeVore
BACKGROUND: Randomized controlled trials typically require study-specific visits, which can burden participants and sites. Remote follow-up, such as centralized call centers for participant-reported or site-reported, holds promise for reducing costs and enhancing the pragmatism of trials. In this secondary analysis of the CONNECT-HF trial, we aimed to evaluate the completeness and validity of the remote follow-up process. METHODS AND RESULTS: CONNECT-HF evaluated the effect of a post-discharge quality improvement intervention for heart failure compared to usual care for up to 1 year...
April 4, 2024: Journal of Cardiac Failure
#39
JOURNAL ARTICLE
Katherine W Saylor, Elizabeth Q Fernandes, Michael Adams, Sarah Paraghamian, David I Shalowitz
OBJECTIVES: To identify predictors of referral and completion of germline genetic testing among newly diagnosed ovarian cancer patients, with a focus on geographic social deprivation, oncologist-level practices, and time between diagnosis and completion of testing. METHODS: Clinical and sociodemographic data were abstracted from medical records of patients newly diagnosed with ovarian cancer between 2014 and 2019 in the University of North Carolina Health System...
April 8, 2024: Gynecologic Oncology
#40
JOURNAL ARTICLE
Amy R Tims, Peter J Unmack, Michael P Hammer, Culum Brown, Mark Adams, Matthew D McGee
Crater lake fishes are common evolutionary model systems, with recent studies suggesting a key role for gene flow in promoting rapid adaptation and speciation. However, the study of these young lakes can be complicated by human-mediated extinctions. Museum genomics approaches integrating genetic data from recently extinct species are therefore critical to understanding the complex evolutionary histories of these fragile systems. Here, we examine the evolutionary history of an extinct Southern Hemisphere crater lake endemic, the rainbowfish Melanotaenia eachamensis...
April 10, 2024: Systematic Biology
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