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Michael A. Adams

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https://www.readbyqxmd.com/read/29789355/hdl-functionality-and-cardiovascular-outcome-among-non-dialysis-chronic-kidney-disease-patients
#1
Kathrin Untersteller, Sabine Meissl, Markus Trieb, Insa Emrich, Adam Zawada, Michael Holzer, Eva Knuplez, Danilo Fliser, Gunnar Heine, Gunther Marsche
Cardiovascular disease remains the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). CKD profoundly affects high-density lipoprotein (HDL) composition and functionality, but if abnormal HDL independently contributes to cardiovascular events in CKD patients remains elusive. In the present study, we assessed whether compositional and functional properties of HDL predict cardiovascular outcome among 526 non-dialysis CKD patients who participate in the CARE FOR HOMe study. We measured HDL cholesterol, the content of HDL-associated pro-inflammatory serum amyloid A (SAA) and activities of the HDL enzymes paraoxonase and lipoprotein associated phospholipase A2 (Lp-PLA2)...
May 22, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29788236/a-novel-adeno-associated-virus-capsid-with-enhanced-neurotropism-corrects-a-lysosomal-transmembrane-enzyme-deficiency
#2
Julie Tordo, Claire O'Leary, André S L M Antunes, Nuria Palomar, Patrick Aldrin-Kirk, Mark Basche, Antonette Bennett, Zelpha D'Souza, Hélène Gleitz, Annie Godwin, Rebecca J Holley, Helen Parker, Ai Yin Liao, Paul Rouse, Amir Saam Youshani, Larbi Dridi, Carla Martins, Thierry Levade, Kevin B Stacey, Daniel M Davis, Adam Dyer, Nathalie Clément, Tomas Björklund, Robin R Ali, Mavis Agbandje-McKenna, Ahad A Rahim, Alexey Pshezhetsky, Simon N Waddington, R Michael Linden, Brian W Bigger, Els Henckaerts
Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are low transduction rates and inefficient distribution of the vector. To overcome these hurdles, a variety of capsid engineering methods have been utilized to generate capsids with improved transduction properties...
May 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29786623/rating-of-perceived-exertion-as-a-method-of-volume-autoregulation-within-a-periodized-program
#3
Eric R Helms, Matt R Cross, Scott R Brown, Adam Storey, John Cronin, Michael C Zourdos
Helms, ER, Cross, MR, Brown, SR, Storey, A, Cronin, J, and Zourdos, MC. Rating of perceived exertion as a method of volume autoregulation within a periodized program. J Strength Cond Res 32(6): 1627-1636, 2018-The purpose of this investigation was to observe how a rating of perceived exertion (RPE)-based autoregulation strategy impacted volume performed by powerlifters. Twelve (26 ± 7 years, n = 9 men, n = 3 women) nationally qualified powerlifters performed the back squat, bench press, and deadlift 3x per week on nonconsecutive days in a session order of hypertrophy, power, and then strength; for 3 weeks...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29786085/chronic-crh-depletion-from-gabaergic-long-range-projection-neurons-in-the-extended-amygdala-reduces-dopamine-release-and-increases-anxiety
#4
Nina Dedic, Claudia Kühne, Mira Jakovcevski, Jakob Hartmann, Andreas J Genewsky, Karina S Gomes, Elmira Anderzhanova, Max L Pöhlmann, Simon Chang, Adam Kolarz, Annette M Vogl, Julien Dine, Michael W Metzger, Bianca Schmid, Rafael C Almada, Kerry J Ressler, Carsten T Wotjak, Valery Grinevich, Alon Chen, Mathias V Schmidt, Wolfgang Wurst, Damian Refojo, Jan M Deussing
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release...
May 21, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29781568/diastolic-dysfunction-is-associated-with-exercise-impairment-in-patients-with-sickle-cell-anemia
#5
Tarek Alsaied, Omar Niss, Adam W Powell, Robert J Fleck, James F Cnota, Clifford Chin, Punam Malik, Charles T Quinn, Michael D Taylor
BACKGROUND: Left ventricular diastolic dysfunction (DD) is an independent risk factor for mortality in sickle cell anemia (SCA) and is associated with increased extracellular volume (ECV) on cardiac MRI (CMR). Exercise impairment is common in SCA, but its causes and prognostic value are not well understood. OBJECTIVE: To study the effects of DD and ECV on cardiopulmonary exercise test (CPET) in patients with SCA. METHODS AND RESULTS: As part of a prospective study to characterize the cardiomyopathy of SCA (NCT02410811), 20 children and adults with SCA underwent CMR, echocardiography, and cycle ergometer CPET (age range 8-43 years)...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29781477/methyl-rotation-dynamics-in-metal-organic-frameworks-probed-with-terahertz-spectroscopy
#6
Qi Li, Adam J Zaczek, Timothy M Korter, J Axel Zeitler, Michael T Ruggiero
In ZIF-8 and its cobalt analogue ZIF-67, the imidazolate methyl-groups, which point directly into the void space, have been shown to freely rotate - even down to cryogenic temperatures. Using a combination of experimental terahertz time-domain spectroscopy, low-frequency Raman spectroscopy, and state-of-the-art ab initio simulations, the methyl-rotor dynamics in ZIF-8 and ZIF-67 are fully characterized within the context of a quantum-mechanical hindered-rotor model. The results lend insight into the fundamental origins of the experimentally observed methyl-rotor dynamics, and provide valuable insight into the nature of the weak interactions present within this important class of materials...
May 21, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29781129/the-role-of-competitive-and-cooperative-norms-in-the-development-of-deviant-evaluations
#7
Luke McGuire, Michael T Rizzo, Melanie Killen, Adam Rutland
The present study examined how peer group norms influence children's evaluations of deviant ingroup members. Following the manipulation of competitive or cooperative norms, participants (children, Mage  = 8.69; adolescents, Mage  = 13.81; adults, Mage  = 20.89; n = 263) evaluated deviant ingroup members from their own and the group's perspective. Children rated cooperative deviancy positively and believed their group would do the same. Adolescents and adults believed that their group would negatively evaluate cooperative deviancy when their group supported a competitive allocation strategy...
May 20, 2018: Child Development
https://www.readbyqxmd.com/read/29781115/c-h-borylation-cross-coupling-forms-twisted-donor-acceptor-compounds-exhibiting-donor-dependent-delayed-emission
#8
Michael Ingleson, Daniel Crossley, Pakapol Kulapichitr, Michael Turner, Joseph McDouall, James Radcliffe, Jay Dunsford, Inigo Vitorica-Yrezabal, Rachel Kahan, Adam Woodward
Benzothiadiazole (BT) directed C-H borylation using BCl3, followed by B-Cl hydrolysis and Suzuki-Miyaura cross coupling enables facile access to twisted donor acceptor compounds. A subsequent second C-H borylation step provides, on arylation of boron, access to borylated highly twisted D-A compounds with a reduced band gap, or on B-Cl hydrolysis/cross coupling to twisted D-A-D compounds. Photophysical studies revealed that in this series there is long lifetime emission only when the donor is triphenylamine...
May 21, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29780867/topographic-staging-of-tau-positron-emission-tomography-images
#9
Adam J Schwarz, Sergey Shcherbinin, Lawrence J Slieker, Shannon L Risacher, Arnaud Charil, Michael C Irizarry, Adam S Fleisher, Sudeepti Southekal, Abhinay D Joshi, Michael D Devous, Bradley B Miller, Andrew J Saykin
Introduction: It has been proposed that the signal distribution on tau positron emission tomography (PET) images could be used to define pathologic stages similar to those seen in neuropathology. Methods: Three topographic staging schemes for tau PET, two sampling the temporal and occipital subregions only and one sampling cortical gray matter across the major brain lobes, were evaluated on flortaucipir F 18 PET images in a test-retest scenario and from Alzheimer's Disease Neuroimaging Initiative 2...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29779976/the-discovery-and-preclinical-evaluation-of-bms-707035-a-potent-hiv-1-integrase-strand-transfer-inhibitor
#10
B Narasimhulu Naidu, Michael A Walker, Margaret E Sorenson, Yasutsugu Ueda, John D Matiskella, Timothy P Connolly, Ira B Dicker, Zeyu Lin, Sagarika Bollini, Brian J Terry, Helen Higley, Ming Zheng, Dawn D Parker, Dedong Wu, Stephen Adams, Mark R Krystal, Nicholas A Meanwell
BMS-707035 is an HIV-1 integrase strand transfer inhibitor (INSTI) discovered by systematic optimization of N-methylpyrimidinone carboxamides guided by structure-activity relationships (SARs) and the single crystal X-ray structure of compound 10. It was rationalized that the unexpectedly advantageous profiles of N-methylpyrimidinone carboxamides with a saturated C2-substitutent may be due, in part, to the geometric relationship between the C2-substituent and the pyrimidinone core. The single crystal X-ray structure of 10 provided support for this reasoning and guided the design of a spirocyclic series 12 which led to discovery of the morpholino-fused pyrimidinone series 13...
May 14, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29778641/subregional-volumes-of-the-hippocampus-in-relation-to-cognitive-function-and-risk-of-dementia
#11
Tavia E Evans, Hieab H H Adams, Silvan Licher, Frank J Wolters, Aad van der Lugt, M Kamran Ikram, Michael J O'Sullivan, Meike W Vernooij, M Arfan Ikram
BACKGROUND: Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role of subregions of the hippocampus in cognition and risk of dementia remains relatively underexplored. We studied subregions of the hippocampus in a large population-based cohort to further understand their role in cognitive impairment and dementia risk. METHODS: We studied 5035 dementia- and stroke-free persons from the Rotterdam Study, aged over 45 years...
May 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29778340/prospective-randomized-controlled-trial-of-polymer-cable-ties-versus-standard-wire-closure-of-midline-sternotomy
#12
Silvana F Marasco, Louise Fuller, Adam Zimmet, David McGiffin, Michael Seitz, Stephanie Ch'ng, Shivanand Gangahanumaiah, Michael Bailey
OBJECTIVE: Midline sternotomy remains the most common access incision for cardiac operations. Traditionally, the sternum is closed with stainless steel wires. Wires are well known to stretch and break, however, leading to pain, nonunion, and potential deep sternal wound infection. We hypothesized that biocompatible plastic cable ties would achieve a more rigid sternal fixation, reducing postoperative pain and analgesia requirements. METHODS: A prospective, randomized study compared the ZIPFIX (De Puy Synthes, West Chester, Pa) sternal closure system (n = 58) with standard stainless steel wires (n = 60)...
April 16, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29777672/valvectomy-versus-replacement-for-the-surgical-treatment-of-tricuspid-endocarditis
#13
Adam N Protos, Jaimin R Trivedi, William M Whited, Michael P Rogers, Ugochukwu Owolabi, Kendra J Grubb, Kristen Sell-Dottin, Mark S Slaughter
BACKGROUND: Optimal surgical treatment of infective tricuspid endocarditis is debatable, especially in the setting of inherent social and pathologic concerns. This study seeks to compare tricuspid valve repair, replacement, and excision for the treatment of infective endocarditis METHODS: A single center cardiac surgery database was queried between 2012 and 2016 to identify patients >18 years who underwent tricuspid valve surgery for infective endocarditis. Patients were divided into 3 groups based on the type of tricuspid valve surgery: valvectomy, repair, or replacement and evaluated to identify differences between the pre-op factors and outcomes including mortality, length of stay, and complications...
May 16, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29777634/characterisation-of-the-outer-membrane-proteome-of-francisella-noatunensis-subsp-orientalis
#14
Khalid Shahin, Kim D Thompson, Neil F Inglis, Kevin Mclean, Jose Gustavo Ramirez-Paredes, Sean J Monaghan, Rowena Hoare, Michael Fontaine, Matthijs Metselaar, Alexandra Adams
AIMS: The aims of the current study were to characterise the outer membrane proteins (OMPs) of Francisella noatunensis subsp. orientalis (Fno) STIR-GUS-F2f7, and identify proteins recognised by sera from tilapia, Oreochromis niloticus, (L) that survived experimental challenge with Fno. METHODS AND RESULTS: The composition of the OMPs of a virulent strain of Fno (STIR-GUS- F2f7), isolated from diseased red Nile tilapia in UK, was examined. The sarcosine-insoluble OMP fraction was screened with tilapia hyper-immune sera by western blot analysis following separation of the proteins by 1D SDS-PAGE...
May 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29776529/characteristics-of-construction-firms-at-risk-for-future-workers-compensation-claims-using-administrative-data-systems-washington-state
#15
Jennifer L Marcum, Michael Foley, Darrin Adams, Dave Bonauto
INTRODUCTION: Construction is high-hazard industry, and continually ranks among those with the highest workers' compensation (WC) claim rates in Washington State (WA). However, not all construction firms are at equal risk. We tested the ability to identify those construction firms most at risk for future claims using only administrative WC and unemployment insurance data. METHODS: We collected information on construction firms with 10-50 average full time equivalent (FTE) employees from the WA unemployment insurance and WC data systems (n=1228)...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29773892/metabolite-cycled-density-weighted-concentric-rings-k-space-trajectory-dw-crt-enables-high-resolution-1-h-magnetic-resonance-spectroscopic-imaging-at-3-tesla
#16
Adam Steel, Mark Chiew, Peter Jezzard, Natalie L Voets, Puneet Plaha, Michael Albert Thomas, Charlotte J Stagg, Uzay E Emir
Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling in combination with semi-LASER excitation and metabolite-cycling enables high-resolution MRSI data to be rapidly acquired at 3 Tesla...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773230/medications-received-by-patients-with-juvenile-dermatomyositis
#17
Takayuki Kishi, Nastaran Bayat, Michael M Ward, Adam M Huber, Lan Wu, Gulnara Mamyrova, Ira N Targoff, William J Warren-Hicks, Frederick W Miller, Lisa G Rider
OBJECTIVE: Few controlled studies are available to guide treatment decisions in juvenile dermatomyositis (JDM). This study evaluated therapies received, changes of treatment over time, and factors associated with medication choices in JDM. METHODS: We performed a retrospective analysis of the number and type of therapies and duration of treatment for 320 patients with JDM enrolled in a North American registry. Kaplan-Meier and logistic regression analysis were used to assess the association of demographic and clinical features and autoantibodies with medication usage...
March 28, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29770463/a-first-for-dermatopathology-and-pathology-in-general-appropriate-use-criteria-in-dermatopathology-from-the-american-society-of-dermatopathology
#18
Adam I Rubin, Michael Hitchcock
In this issue of the Journal of Cutaneous Pathology(1), the ASDP Appropriate Use Criteria (AUC) Task Force releases a landmark series of recommendations on AUC from the American Society of Dermatopathology. This is the first set of AUC in dermatopathology and, indeed, in pathology overall. These recommendations were developed as part of the work of the ASDP AUC Task Force, created in 2015. This publication provides strong, evidence-based recommendations that will improve the delivery and utilization of care for our patients, just as AUC for Mohs surgery have elevated the discourse on that procedure for the benefit of patients and society as a whole(2)...
May 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29770271/comparison-of-hoop-net-trapping-and-visual-surveys-to-monitor-abundance-of-the-rio-grande-cooter-pseudemys-gorzugi
#19
Ivana Mali, Adam Duarte, Michael R J Forstner
Abundance estimates play an important part in the regulatory and conservation decision-making process. It is important to correct monitoring data for imperfect detection when using these data to track spatial and temporal variation in abundance, especially in the case of rare and elusive species. This paper presents the first attempt to estimate abundance of the Rio Grande cooter ( Pseudemys gorzugi ) while explicitly considering the detection process. Specifically, in 2016 we monitored this rare species at two sites along the Black River, New Mexico via traditional baited hoop-net traps and less invasive visual surveys to evaluate the efficacy of these two sampling designs...
2018: PeerJ
https://www.readbyqxmd.com/read/29768178/trained-memory-of-human-uterine-nk-cells-enhances-their-function-in-subsequent-pregnancies
#20
Moriya Gamliel, Debra Goldman-Wohl, Batya Isaacson, Chamutal Gur, Natan Stein, Rachel Yamin, Michael Berger, Myriam Grunewald, Eli Keshet, Yoach Rais, Chamutal Bornstein, Eyal David, Adam Jelinski, Iris Eisenberg, Caryn Greenfield, Arbel Ben-David, Tal Imbar, Ronit Gilad, Ronit Haimov-Kochman, David Mankuta, Matan Elami-Suzin, Ido Amit, Jacob H Hanna, Simcha Yagel, Ofer Mandelboim
Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast invasion and angiogenesis. Several diseases of poor placental development are associated with first pregnancies, so we thus looked to characterize differences in decidual NKs (dNKs) in first versus repeated pregnancies. We discovered a population found in repeated pregnancies, which has a unique transcriptome and epigenetic signature, and is characterized by high expression of the receptors NKG2C and LILRB1. We named these cells Pregnancy Trained decidual NK cells (PTdNKs)...
May 15, 2018: Immunity
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