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https://www.readbyqxmd.com/read/29310816/the-clinical-characteristics-of-adult-bacterial-meningitis-caused-by-non-pseudomonas-ps-aeruginosa-pseudomonas-species-a-clinical-comparison-with-ps-aeruginosa-meningitis
#1
Chi-Ren Huang, Chia-Yi Lien, Wan-Chen Tsai, Wei-An Lai, Che-Wei Hsu, Nai-Wen Tsai, Chiung-Chih Chang, Cheng-Hsien Lu, Chun-Chih Chien, Wen-Neng Chang
Adult bacterial meningitis (ABM) caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas (NPAP) species infection has rarely been reported. The clinical characteristics of 52 cases of Pseudomonas ABM (11 NPAP- and 41 Ps. aeruginosa-related meningitis) collected during a 30-year study period (1986-2015) were included. Eleven cases of NPAP ABM were identified in the literature, and their clinical data were also collected. Therefore, a total of 22 NPAP ABM cases were enrolled. The clinical characteristics of the NPAP ABM and Ps...
January 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29288749/enhanced-wakefulness-following-lesions-of-a-mesopontine-locus-essential-for-the-induction-of-general-anesthesia
#2
Sa'ar Lanir-Azaria, Guy Meiri, Tamir Avigdor, Anne Minert, Marshall Devor
The induction of general anesthesia shares many features with the transition from wakefulness to non-rapid eye movement (NREM) sleep, suggesting that the two types of brain-state transition are orchestrated by a common neuronal mechanism. Previous studies revealed a brainstem locus, the mesopontine tegmental anesthesia area (MPTA), that is of singular importance for anesthetic induction. Microinjection there of GABAergic anesthetics induces rapid loss-of-consciousness and lesions render the animal relatively insensitive to anesthetics administered systemically...
December 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29278634/pain-intensity-scales-comparison-in-patient-with-abdominal-pain
#3
Zoran Trninić, Manja Spahalić, Gordan Galić, Davorin Kozomara, Valentina Lasić, Danijel Bevanda, Nikica Šutalo
BACKGROUND: The aim of study was to explore efficiency of the pain rating scales on patients experiencing abdominal pain, determine correlation between the scales and their applicability to general population and determine the minimal clinical important difference in mm on the VAS as discriminatory for difference in pain intensity. SUBJECTS AND METHODS: The study was performed at the Emergency Department of the University Clinical Hospital of Mostar on patients with abdominal pain which started less than 24 hours before, excluding patients under 16 years old, uncooperative patients and those with altered state of consciousness...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29213515/rehabilitation-in-severe-memory-deficit-a-case-study
#4
Nariana Mattos Figueiredo Sousa
The term amnesia refers to a pathological state of mind in which memory and learning are affected to a greater extent than other cognitive functions in a patient without altered level of consciousness. The aim of the current study was to describe a case of severe amnesia in a patient during neurological rehabilitation and to report the importance of preserved cognitive functions to compensate for the mnemonic deficit. VJA presented a clinical condition suggestive of encephalopathy due to caloric-protein malnutrition following several abdominal surgical procedures for complicated choledocholithiasis...
April 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29197090/syndrome-of-transient-headache-and-neurologic-deficits-with-cerebrospinal-fluid-lymphocitosis-should-be-considered-in-children-presenting-with-acute-confusional-state
#5
Romina Moavero, Laura Papetti, Samuela Tarantino, Barbara Battan, Irene Salfa, Annalisa Deodati, Riccardo Schiaffini, Federico Vigevano, Massimiliano Valeriani
BACKGROUND: Transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) is benign and self-limited, with neurologic deficits including sensory disturbance of one body side, aphasia, nausea/vomiting, weakness, decreased vision, homonymous hemianopsia, photophobia. Acute confusional state can rarely occur. Papilledema and intracranial hypertension have also been described. It is a rare entity mainly affecting adults; however, it has been sporadically described in children and adolescents...
December 2, 2017: Headache
https://www.readbyqxmd.com/read/29167644/lsd-increases-primary-process-thinking-via-serotonin-2a-receptor-activation
#6
Rainer Kraehenmann, Dan Pokorny, Helena Aicher, Katrin H Preller, Thomas Pokorny, Oliver G Bosch, Erich Seifritz, Franz X Vollenweider
Rationale: Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previously been shown to increase primary process thinking - an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces primary process thinking under placebo-controlled, standardized experimental conditions and whether these effects are related to subjective experience and 5-HT2A receptor activation...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29167538/a-deep-dream-virtual-reality-platform-for-studying-altered-perceptual-phenomenology
#7
Keisuke Suzuki, Warrick Roseboom, David J Schwartzman, Anil K Seth
Altered states of consciousness, such as psychotic or pharmacologically-induced hallucinations, provide a unique opportunity to examine the mechanisms underlying conscious perception. However, the phenomenological properties of these states are difficult to isolate experimentally from other, more general physiological and cognitive effects of psychoactive substances or psychopathological conditions. Thus, simulating phenomenological aspects of altered states in the absence of these other more general effects provides an important experimental tool for consciousness science and psychiatry...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29160761/fronto-parietal-coherence-response-to-tdcs-modulation-in-patients-with-disorders-of-consciousness
#8
Yang Bai, Xiaoyu Xia, Yong Wang, Yongkun Guo, Yi Yang, Jianghong He, Xiaoli Li
A transcranial direct current stimulation (tDCS) protocol (2 min, 2 mA, anodal electrode at the left dorsolateral prefrontal cortex and cathodal electrode at the right supraorbital area) was applied in patients with different degrees of disorders of consciousness (DoC). Although previous research indicates that it could improve patients' coma recovery scale-revised (CRS-R) scores, the brain's electrophysiological responses to tDCS are still unclear. Therefore, the present study was performed to explore the underlying brain responses of patients in a minimally conscious state (MCS) and a Unresponsive Wakefulness Syndrome (UWS) to tDCS modulation...
November 21, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29146105/content-validation-of-behaviours-and-autonomic-responses-for-the-assessment-of-pain-in-critically-ill-adults-with-a-brain-injury
#9
Céline Gélinas, Kathleen A Puntillo, Madalina Boitor, Mélanie Bérubé, Jane Topolovec-Vranic, Anne-Sylvie Ramelet, Aaron M Joffe, Melissa Richard-Lalonde, Francis Bernard, David L Streiner
BACKGROUND: The evidence shows that brain-injured patients express behaviours that are related to their level of consciousness (LOC), and different from other patients in the intensive care unit (ICU). Therefore, existing behavioural scales should be revised to enhance their content and validity for use in these patients. OBJECTIVES: The aim was to evaluate the content relevance of behaviours and autonomic responses for pain assessment of brain-injured ICU patients from the perspective of critical care clinicians...
November 13, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29121879/hypnotic-susceptibility-and-affective-states-in-bipolar-i-and-ii-disorders
#10
Bingren Zhang, Jiawei Wang, Qisha Zhu, Guorong Ma, Chanchan Shen, Hongying Fan, Wei Wang
BACKGROUND: Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. METHODS: The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test, the Mood Disorder Questionnaire (MDQ), the Hypomanic Checklist-32 (HCL-32) and the Plutchick-van Praag Depression Inventory (PVP) were applied to 62 patients with bipolar I disorder, 33 bipolar II disorder, and 120 healthy volunteers...
November 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29116669/altered-states-of-consciousness-evaluation-of-a-voice-hearing-simulation-during-an-immersive-art-exhibition
#11
Simon Riches, Rich Maskey, Rachel Waddingham, Jonny Benjamin, Patrick Dishman, Charlie Tebrook, Eve Mundy, Phoebe Roberts, Helen L Fisher
AIM: To improve public understanding of the subjective experience of auditory hallucinations and increase empathy towards individuals who hear voices and have other unusual sensory experiences. METHODS: This pilot study developed a new immersive art exhibition, Altered States of Consciousness, which gave members of the public an individualized voice-hearing simulation experience in 2 real-world settings-an art gallery and the London Underground. A total of 150 visitors completed visual analogue scales immediately before and after their experience of the exhibition...
November 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29101022/lsd-modulates-effective-connectivity-and-neural-adaptation-mechanisms-in-an-auditory-oddball-paradigm
#12
REVIEW
Christopher Timmermann, Meg J Spriggs, Mendel Kaelen, Robert Leech, David J Nutt, Rosalyn J Moran, Robin L Carhart-Harris, Suresh D Muthukumaraswamy
Under the predictive coding framework, perceptual learning and inference are dependent on the interaction between top-down predictions and bottom-up sensory signals both between and within regions in a network. However, how such feedback and feedforward connections are modulated in the state induced by lysergic acid diethylamide (LSD) is poorly understood. In this study, an auditory oddball paradigm was presented to healthy participants (16 males, 4 female) under LSD and placebo, and brain activity was recorded using magnetoencephalography (MEG)...
October 31, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29095071/n-n-dimethyltryptamine-and-the-pineal-gland-separating-fact-from-myth
#13
David E Nichols
The pineal gland has a romantic history, from pharaonic Egypt, where it was equated with the eye of Horus, through various religious traditions, where it was considered the seat of the soul, the third eye, etc. Recent incarnations of these notions have suggested that N,N-dimethyltryptamine is secreted by the pineal gland at birth, during dreaming, and at near death to produce out of body experiences. Scientific evidence, however, is not consistent with these ideas. The adult pineal gland weighs less than 0...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29073221/distinct-retrosplenial-cortex-cell-populations-and-their-spike-dynamics-during-ketamine-induced-unconscious-state
#14
Grace E Fox, Meng Li, Fang Zhao, Joe Z Tsien
Ketamine is known to induce psychotic-like symptoms, including delirium and visual hallucinations. It also causes neuronal damage and cell death in the retrosplenial cortex (RSC), an area that is thought to be a part of high visual cortical pathways and at least partially responsible for ketamine's psychotomimetic activities. However, the basic physiological properties of RSC cells as well as their response to ketamine in vivo remained largely unexplored. Here, we combine a computational method, the Inter-Spike Interval Classification Analysis (ISICA), and in vivo recordings to uncover and profile excitatory cell subtypes within layers 2&3 and 5&6 of the RSC in mice within both conscious, sleep, and ketamine-induced unconscious states...
2017: PloS One
https://www.readbyqxmd.com/read/29060032/change-in-functional-networks-for-transitions-between-states-of-consciousness-during-midazolam-induced-sedation
#15
Minji Lee, Robert D Sanders, Seul-Ki Yeom, Dong-Ok Won, Hwi-Jae Kim, Bo-Ram Lee, Kwang-Suk Seo, Hyun Jeong Kim, Giulio Tononi, Seong-Whan Lee
How brain dynamics change across conscious states, including reliable signatures of the transitions between unconsciousness and consciousness, remains unclear. In this work, we addressed the changes in functional brain networks during self-titrated midazolam sedation using high-density electroencephalography (EEG) in ten subjects. We were particularly interested in the underlying network alterations, identified with graph theory, associated with transitions between states of consciousness. The weighted Phase Lag Index (wPLI) was used as the connectivity estimator between two signals...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29050394/cortical-neurons-and-networks-are-dormant-but-fully-responsive-during-isoelectric-brain-state
#16
Tristan Altwegg-Boussac, Adrien E Schramm, Jimena Ballestero, Fanny Grosselin, Mario Chavez, Sarah Lecas, Michel Baulac, Lionel Naccache, Sophie Demeret, Vincent Navarro, Séverine Mahon, Stéphane Charpier
A continuous isoelectric electroencephalogram reflects an interruption of endogenously-generated activity in cortical networks and systematically results in a complete dissolution of conscious processes. This electro-cerebral inactivity occurs during various brain disorders, including hypothermia, drug intoxication, long-lasting anoxia and brain trauma. It can also be induced in a therapeutic context, following the administration of high doses of barbiturate-derived compounds, to interrupt a hyper-refractory status epilepticus...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050383/early-detection-of-consciousness-in-patients-with-acute-severe-traumatic-brain-injury
#17
Brian L Edlow, Camille Chatelle, Camille A Spencer, Catherine J Chu, Yelena G Bodien, Kathryn L O'Connor, Ronald E Hirschberg, Leigh R Hochberg, Joseph T Giacino, Eric S Rosenthal, Ona Wu
See Schiff (doi:10.1093/awx209) for a scientific commentary on this article. Patients with acute severe traumatic brain injury may recover consciousness before self-expression. Without behavioural evidence of consciousness at the bedside, clinicians may render an inaccurate prognosis, increasing the likelihood of withholding life-sustaining therapies or denying rehabilitative services. Task-based functional magnetic resonance imaging and electroencephalography techniques have revealed covert consciousness in the chronic setting, but these techniques have not been tested in the intensive care unit...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29032875/ventilator-use-by-emergency-medical-services-during-911-calls-in-the-united-states
#18
Mazen El Sayed, Hani Tamim, Aurelie Mailhac, Mann N Clay
BACKGROUND: Emergency and transport ventilators use in the prehospital field is not well described. This study examines trends of ventilator use by EMS agencies during 911 calls in the United States and identifies factors associated with this use. METHODS: This retrospective study used four consecutive releases of the US National Emergency Medical Services Information System (NEMSIS) public research dataset (2011-2014) to describe scene EMS activations (911 calls) with and without reported ventilator use...
October 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29029313/subjective-objective-sleep-discrepancy-is-associated-with-alterations-in-regional-glucose-metabolism-in-patients-with-insomnia-and-good-sleeper-controls
#19
Daniel B Kay, Helmet T Karim, Adriane M Soehner, Brant P Hasler, Jeffrey A James, Anne Germain, Martica H Hall, Peter L Franzen, Julie C Price, Eric A Nofzinger, Daniel J Buysse
Objectives: Sleep discrepancies are common in primary insomnia (PI) and include reports of longer sleep onset latency (SOL) than measured by polysomnography (PSG) or "negative SOL discrepancy." We hypothesized that negative SOL discrepancy in PI would be associated with higher relative glucose metabolism during nonrapid eye movement (NREM) sleep in brain networks involved in conscious awareness, including the salience, left executive control, and default mode networks. Methods: PI (n = 32) and good sleeper controls (GS; n = 30) completed [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) scans during NREM sleep, and relative regional cerebral metabolic rate for glucose (rCMRglc) was measured...
November 1, 2017: Sleep
https://www.readbyqxmd.com/read/28986208/dynamic-functional-connectivity-and-brain-metastability-during-altered-states-of-consciousness
#20
REVIEW
Federico Cavanna, Martina G Vilas, Matías Palmucci, Enzo Tagliazucchi
The scientific study of human consciousness has greatly benefited from the development of non-invasive brain imaging methods. The quest to identify the neural correlates of consciousness combined psychophysical experimentation with neuroimaging tools such as functional magnetic resonance imaging (fMRI) to map the changes in neural activity associated with conscious vs. unconscious percepts. Different neuroimaging methods have also been applied to characterize spontaneous brain activity fluctuations during altered states of consciousness, and to develop quantitative metrics for the level of consciousness...
October 3, 2017: NeuroImage
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