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https://www.readbyqxmd.com/read/28524035/-comparison-of-risk-of-death-between-older-and-non-older-critical-patients-in-icu-a-retrospective-cohort-study-of-consecutive-3-years
#1
Yeting Zhou, Daoming Tong, Shaodan Wang, Liansong Liu, Song Ye, Benwen Xu
OBJECTIVE: To investigate the risk of death between older and non-older critical patients in intensive care unit (ICU) in Shuyang People's Hospital. METHODS: A retrospective cohort study was conducted. The critical patients who aged 15 or above, and admitted to ICU of Shuyang People's Hospital from January 2014 to December 2016 were enrolled, and all the data was collected from the registration and electronic medical records in the ICU. The prevalence and causes of death in ICU critical patients during the study period were observed...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28523906/facile-synthesis-of-three-dimensional-sandwiched-mno2-gcs-mno2-hybrid-nanostructured-electrode-for-electrochemical-capacitors
#2
Xian Jian, Shiyu Liu, Yuqi Gao, Wanli Zhang, Weidong He, Asif Mahmood, Chandrasekar M Subramaniyam, Xiaolin Wang, Nasir Mahmood, Shixue Dou
Designable control over morphology and structure of active materials is highly-desirable for achieving high-performance devices. Here, we develop a facile microwave assisted synthesis to decorate MnO2 nanocrystals on three dimensional (3D) graphite-like capsules (GCs) for obtaining sandwich nanostructures (3D MnO2@GCs@MnO2) as electrode materials for electrochemical capacitors (ECs). A templated growth of 3D GCs is carried out via catalytic chemical vapour deposition (CCVD) and MnO2 is decorated on exterior and interior surfaces of GC walls through microwave irradiation to build engineered architecture with robust structural and morphological stability...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28523336/multum-in-parvo
#3
Dan Cristian Voinescu, Aurel George Mohan, Andrei Alexandru Marinescu, Alexandru Vlad Ciurea
The authors begin from the Latin expression Multum in parvo, which is used to summarize the essential aspects of something. This phrase is used in this case to define the Glasgow Coma Scale (GCS) - the posttraumatic conscious state evaluation scale. The authors gather the entire information regarding the creation of a uniform evaluation scale for the patients that have the state of consciousness altered or are even in a posttraumatic coma. This subject has been thoroughly debated for over 40 years. Teasdale & Jennett represented a huge step in the evaluation of patient's state of consciousness...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28523300/prenatal-glucocorticoid-administration-persistently-increased-the-immunohistochemical-expression-of-type-1-metabotropic-glutamate-receptor-and-purkinje-cell-dendritic-growth-in-the-cerebellar-cortex-of-the-rat
#4
Rodrigo Pascual, Odra Santander, Isabel Cuevas, Martina Valencia
Several studies have indicated that abnormal prenatal changes in the circulating glucocorticoids (GCs), induced by either maternal stress or exogenous GC administration, significantly alter the development of Purkinje cells (PCs). Among the suggested mechanisms that could mediate this GC-dependent PC susceptibility are changes in the expression of type-1 metabotropic glutamate receptors (mGluR1). In the current study, we analyzed whether a single course of prenatally administered betamethasone phosphate (BET) in pregnant rats increased the immunohistochemical expression of mGluR1 in PCs and decreased PC dendritic growth...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28521903/motorcycle-related-hospitalizations-of-the-elderly
#5
Ching-Hua Hsieh, Hang-Tsung Liu, Shiun-Yuan Hsu, Hsiao-Yun Hsieh, Yi-Chun Chen
BACKGROUND: To investigate the injury pattern, mechanisms, severity, and mortality of the elderly hospitalized for treatment of trauma following motorcycle accidents. METHODS: Motorcycle-related hospitalization of 994 elderly and 5078 adult patients from the 16,548 hospitalized patients registered in the Trauma Registry System between January 1, 2009 and December 31, 2013. RESULTS: The motorcycle-related elderly trauma patients had higher injury severity, less favorable outcomes, higher proportion of patients admitted to the intensive care unit (ICU), prolonged hospital and ICU stays and higher mortality than those adult motorcycle riders...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28515280/airway-epithelial-cells-are-crucial-targets-of-glucocorticoids-in-a-mouse-model-of-allergic-asthma
#6
Carina Klaßen, Anna Karabinskaya, Lien Dejager, Sabine Vettorazzi, Justine Van Moorleghem, Fred Lühder, Sebastiaan H Meijsing, Jan P Tuckermann, Hanibal Bohnenberger, Claude Libert, Holger M Reichardt
Although glucocorticoids (GCs) are a mainstay in the clinical management of asthma, the target cells that mediate their therapeutic effects are unknown. Contrary to our expectation, we found that GC receptor (GR) expression in immune cells was dispensable for successful therapy of allergic airway inflammation (AAI) with dexamethasone. Instead, GC treatment was compromised in mice expressing a defective GR in the nonhematopoietic compartment or selectively lacking the GR in airway epithelial cells. Further, we found that an intact GR dimerization interface was a prerequisite for the suppression of AAI and airway hyperresponsiveness by GCs...
May 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28514205/apj-is-associated-with-treatment-response-in-gastric-cancer-patients-receiving-concurrent-chemoradiotherapy-and-endostar-therapy
#7
Yan-Zhang Hao, Mian-Li Li, Fang-Ling Ning, Xiu-Wen Wang
BACKGROUND: Endostar combined with concurrent chemoradiotherapy (CRT) has been used in patients with gastric cancers (GCs). However, there are no reliable markers to predict the treatment response and prognosis of these patients. Apelin and its receptor (APJ) are involved in angiogenesis in tumor tissues. We aimed to study whether Apelin and Apelin receptor (APJ) tumor expression can predict the treatment response of combination therapy of endostar and CRT. MATERIALS AND METHODS: We enrolled patients with locally advanced GC receiving CRT only and CRT+endostar combination therapy...
May 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28513991/immunoprotective-effect-of-chitosan-particles-on-hymenolepis-nana-infected-mice
#8
Mahmoud Abdel-Latif, Gamal El-Shahawi, Shawky M Aboelhadid, Heba Abdel-Tawab
Hymenolepis nana is the most commonly known intestinal cestode infecting mainly human. The present study aimed to investigate the potential effect of chitosan particles (CSP) to enhance the immune system against H. nana infection. Determination of worm burden, egg output, histopathological changes, oxidative stress markers (lipid peroxidation & reduced glutathione), goblet (GCs) and mucosal mast cells (MMCs) counts in intestinal ileum were performed. In addition, levels of intestinal mRNA expression of interleukin (IL)-4, IL-9, stem cell factor (SCF), type I & II interferons (IFN)-α/ γ, tumor necrosis factor (TNF)-α, mucin 2 (MUC2), and inducible nitric oxide synthase (iNOs) were investigated using real-time PCR...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28513870/activation-of-the-nrf2-are-signaling-pathway-prevents-hyperphosphatemia-induced-vascular-calcification-by-inducing-autophagy-in-renal-vascular-smooth-muscle-cells
#9
Li Yao, Jian Wang, Bin-Yao Tian, Tian-Hua Xu, Zi-Tong Sheng
This study investigates the effect of nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) signaling pathway in vascular calcification (VC) via inducing Autophagy in renal vascular smooth muscle cells (VSMCs). VSMCs were assigned into six experimental groups: the normal control, high phosphorus, si-negative control (si-NC), Nrf2-siRNA, over-expressed Nrf2 and negative control (NC) groups. RT-PCR was applied to detect the mRNA expressions of the desired Nrf2-ARE signaling pathway-related genes (Nrf2, NQO-1, HO-1, γ-GCS)...
May 17, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28513573/nrf2-inhibits-periodontal-ligament-stem-cell-apoptosis-under-excessive-oxidative-stress
#10
Yanli Liu, Hongxu Yang, Yi Wen, Bingyi Li, Yinhua Zhao, Jing Xing, Min Zhang, Yongjin Chen
The present study aimed to analyze novel mechanisms underlying Nrf2-mediated anti-apoptosis in periodontal ligament stem cells (PDLSCs) in the periodontitis oxidative microenvironment. We created an oxidative stress model with H₂O₂-treated PDLSCs. We used real-time PCR, Western blotting, TUNEL staining, fluorogenic assay and transfer genetics to confirm the degree of oxidative stress and apoptosis as well as the function of nuclear factor-erythroid 2-related factor 2 (Nrf2). We demonstrated that with upregulated levels of reactive oxygen species (ROS) and malondialdehyde (MDA), the effect of oxidative stress was obvious under H₂O₂ treatment...
May 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28512614/postoperative-contralateral-hematoma-in-patient-with-acute-traumatic-brain-injury
#11
Myeong-Jin Oh, Je Hoon Jeong, Dong-Seong Shin, Sun-Chul Hwang, Soo Bin Im, Bum-Tae Kim, Won-Han Shin
OBJECTIVE: Head injury is a leading cause of death and disability in subjects who suffer a traumatic accident. Contralateral hematomas after surgery for traumatic brain injury are rare. However, an unrecognized, these hematomas can cause devastating results. We presented our experience of these patients and discussed diagnosis and management. METHODS: This study included 12 traumatic patients with acute traumatic brain injury who developed delayed contralateral hematoma after evacuation of an acute hematoma...
April 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/28511026/hdac2-is-required-by-the-physiological-concentration-of-glucocorticoid-to-inhibit-inflammation-in-cardiac-fibroblasts
#12
Haining Zhang, Yanhua He, Guiping Zhang, Xiaobin Li, Suikai Yan, Ning Hou, Qing Xiao, Yue Huang, Miaoshan Luo, Genshui Zhang, Quan Yi, Minsheng Chen, Jiandong Luo
We previously suggested that endogenous glucocorticoids (GCs) may inhibit myocardial inflammation induced by lipopolysaccharide (LPS) <i>in vivo</i>. However, the possible cellular and molecular mechanisms were poorly understood. In this study, we investigated the role of physiological concentration of GCs in inflammation induced by LPS in cardiac fibroblasts and explored the possible mechanisms. The results showed that hydrocortisone at the dose of 127ng/ml (equivalent to endogenous basal level of glucocorticoids) inhibited LPS (100ng/ml)-induced productions of TNF-α and IL-1β in cardiac fibroblasts...
May 16, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28510786/the-impact-of-frailty-on-noninvasive-mechanical-ventilation-in-elderly-medical-intensive-care-unit-patients
#13
Iskender Kara, F Yildirim, A Zerman, Z Gullu, N Boyaci, B B Aydogan, U Gaygisiz, K Gonderen, G Arik, M Turkoglu, M Aydogdu, G Aygencel, Z Ulger, G Gursel
AIM: Many factors affecting noninvasive ventilation (NIV) in critically ill patients have been reported in the literature, but there is no study about the effect of frailty. With this study, the frailty prevalence was evaluated with two different frailty scores among the NIV population of a medical intensive care unit (ICU). Besides, the impact of frailty on NIV success and mortality and its association with NIV application problems were evaluated. METHOD: A prospective observational cohort study was performed on patients who were over 50 years of age and assigned to NIV due to hypercapnic respiratory failure...
May 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28508695/ganglion-cells-are-frequently-present-in-pediatric-mucosal-colorectal-biopsies
#14
Alexandra E Kovach, M Cristina Pacheco
Hirschsprung disease (HD) rarely presents as chronic constipation after the newborn period. At our institution, calretinin immunohistochemistry (CAL) is frequently requested by clinicians on rectal mucosal biopsies (RMBs) taken during colonoscopy in older children in whom suspicion for HD is low. We hypothesized that review of these biopsies would frequently reveal ganglion cells (GCs). We reviewed features of mucosal biopsies (November 2013 to September 2015) from children ≥1 year of age on which clinicians had requested CAL on at least one specimen...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28507998/effects-of-pre-injury-anti-platelet-agents-on-short-term-outcome-of-patients-with-mild-traumatic-brain-injury-a-cohort-study
#15
Davood Farsi, Parviz Karimi, Mani Mofidi, Babak Mahshidfar, Mahdi Rezai, Peyman Hafezimoghadam, Saeed Abbasi
OBJECTIVE: To determine the effects of pre-injury consumption of anti-platelet agents on the 30-day outcomes of patients with mild traumatic brain injury (TBI). METHODS: This prospective cohort study was conducted at three general hospitals in Tehran, Iran between July 2013 and July 2014. The study population included all patients with mild TBI aged over 18 years that medicated with aspirin or clopidogrel before occurring trauma. Within hospitalization, all patients were assessed with respect to in-hospital conditions especially complications and adverse events...
April 2017: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/28507801/the-novel-negative-checkpoint-regulator-vista-is-expressed-in-gastric-carcinoma-and-associated-with-pd-l1-pd-1-a-future-perspective-for-a-combined-gastric-cancer-therapy
#16
Christine Böger, Hans-Michael Behrens, Sandra Krüger, Christoph Röcken
A combined blockade of V-domain Ig suppressor of T-cell activation (VISTA) and PD-1 is a promising new cancer treatment option, which was efficient in murine tumor models and is currently tested in first phase I studies. Here, we analyzed the VISTA expression in a large and well-characterized gastric cancer (GC) cohort on 464 therapy-naive GC samples and 14 corresponding liver metastases using immunohistochemistry. Staining results were correlated with clinico-pathological characteristics, genetic alterations and survival...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28504848/association-of-traumatic-head%C3%A2-injuries-and-maxillofacial-fractures-a-retrospective-study
#17
Maher M Abosadegh, Shaifulizan Ab Rahman, Norkhafizah Saddki
The association of traumatic head injury (THI) with maxillofacial fractures (MFF) is a major health concern worldwide. In spite of the close anatomical proximity of maxillofacial bones to the cranium, the association of THI with MFF is controversial. The aim of this study was to assess the association between traumatic head injuries (THI) and maxillofacial fractures (MFF). Other factors associated with THI in patients with MFF were also investigated MATERIALS AND METHODS: A hospital-based retrospective study was conducted at the OMFS Unit, Hospital USM, Kelantan, Malaysia...
May 15, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28503281/effect-of-septimeb-tm-as-a-new-natural-extract-on-severe-sepsis-a-randomized-clinical-trial
#18
Alieh Pourdast, Maryam Sanaei, Sirous Jafari, Mostafa Mohammadi, Hossein Khalili, Gita Shafiee, Zeinab Ahadi, Mahsa Rostami, Saba Alizad, Ramin Heshmat, Minoo Mohraz
BACKGROUND: Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate. METHODS: In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28502689/complicated-mild-traumatic-brain-injury-and-the-need-for-imaging-surveillance
#19
Martina Stippler, Jingyi Liu, Rouzbeh Motiei-Langroudi, Zoya Voronovich, Howard Yonas, Roger B Davis
OBJECTIVE: to evaluate the need for repeat head CT in patients with complicated mild traumatic brain injury (cmTBI) determined non-operative after the first head CT METHODS: 380 patients with mild TBI and a positive head CT not needing surgery were included. Changes between first and second head CT were categorized as decreased, increased or stable. RESULTS: Three patients required neurosurgical intervention (0.8%) after the second CT. There were no significant differences in demographics including age, gender, alcohol consumption, anticoagulation status, time between first and second CT, GCS at admission and discharge, and incidence of SAH, EDH, contusion or skull fractures between the operated and non-operated groups...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28502379/external-validation-of-the-clinical-indications-of-computed-tomography-ct-of-the-head-in-patients-with-low-energy-geriatric-hip-fractures
#20
Amrut Borade, Harish Kempegowda, Hemil H Maniar, Anthony De Giacomo, Paul Tornetta, Kasey Bramlett, Andrew J Marcantonio, Lucas S Marchand, Erik N Kubiak, William H Ip, James F Kellam, Jay S Bender, Eric G Meinberg, James Kee, Regis Renard, Michael Suk, Daniel S Horwitz
INTRODUCTION: On evaluation of the clinical indications of computed tomography (CT) scan of head in the patients with low-energy geriatric hip fractures, Maniar et al. identified physical evidence of head injury, new onset confusion, and Glasgow Coma Scale (GCS)<15 as predictive risk factors for acute findings on CT scan. The goal of the present study was to validate these three criteria as predictive risk factors for a larger population in a wider geographical distribution. PATIENTS AND METHODS: Patients ≥65 years of age with low-energy hip fractures from 6 trauma centers in a wide geographical distribution in the United States were included in this study...
April 26, 2017: Injury
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