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https://www.readbyqxmd.com/read/29353391/detection-of-sleep-disordered-breathing-with-ambulatory-holter-monitoring
#1
Ian Grasso, Mark Haigney, David Mortara, Jacob F Collen, Jordanna Hostler, Aimee Moores, Karen Sheikh, William Kelly
PURPOSE: Obstructive sleep apnea (OSA) syndrome is a common condition that can impact clinical outcomes among patients with cardiovascular disease. Screening all subjects with heart disease via polysomnography (PSG) is costly and resource-limited. We sought to compare a Holter monitor-based algorithm to detect OSA to in-laboratory polysomnography (PSG). METHODS: Prospective cohort study of patients undergoing in-laboratory attended PSG for the evaluation of OSA...
January 20, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29353025/efficacy-and-safety-of-fezakinumab-an-anti-il-22-monoclonal-antibody-in-adults-with-moderate-to-severe-atopic-dermatitis-inadequately-controlled-by-conventional-treatments-a-randomized-double-blind-phase-2a-trial
#2
Emma Guttman-Yassky, Patrick M Brunner, Avidan U Neumann, Saakshi Khattri, Ana B Pavel, Kunal Malik, Giselle K Singer, Danielle Baum, Patricia Gilleaudeau, Mary Sullivan-Whalen, Sharon Rose, Shelbi Jim On, Xuan Li, Judilyn Fuentes-Duculan, Yeriel Estrada, Sandra Garcet, Claudia Traidl-Hoffmann, James G Krueger, Mark G Lebwohl
BACKGROUND: IL-22 promotes epidermal hyperplasia and inhibits skin barrier function. OBJECTIVE: Evaluate IL-22 blockade in adults with moderate-to-severe atopic dermatitis (AD). METHODS: Randomized, double-blind, placebo-controlled trial with intravenous fezakinumab monotherapy every 2wks for 10wks, with follow-up assessments until 20wks. SCORAD change from baseline at 12wks served as primary endpoint. RESULTS: At 12wks, mean SCORAD decline was 13·8±2·7 (fezakinumab) vs...
January 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29353024/outcomes-and-mortality-prediction-model-of-critically-ill-adults-with-acute-respiratory-failure-and-interstitial-lung-disease
#3
Whitney Gannon, David J Lederer, Mauer Biscotti, Azka Javaid, Nina Patel, Daniel Brodie, Matthew Bacchetta, Matthew Baldwin
BACKGROUND: We aimed to examine short- and long-term mortality in a mixed population of interstitial lung disease (ILD) patients with acute respiratory failure, and to identify those at lower versus higher risk of in-hospital death. METHODS: We conducted a single-center retrospective cohort study of 126 consecutive adults with ILD admitted to an intensive care unit (ICU) for respiratory failure at a tertiary care hospital between 2010 and 2014 who did not undergo lung transplantation during their hospitalization...
January 15, 2018: Chest
https://www.readbyqxmd.com/read/29352472/the-bioequivalence-of-a-single-intravenous-administration-of-the-anesthetic-alfaxalone-in-cyclodextrin-versus-alfaxalone-in-cyclodextrin-plus-preservatives-in-cats
#4
K Pasloske, M G Ranasinghe, S Sauer, J Hare
To demonstrate the bioequivalence of alfaxalone in cyclodextrin (Reference Product) to a formulation of alfaxalone in cyclodextrin also containing the preservatives ethanol, chlorocresol, and benzethonium chloride (Test Product) when administered for the purpose of inducing anesthesia in the cat. Blinded, single-dose, randomized, two-period, two-sequence, cross-over bioequivalence study with a 7-day washout period between treatments. Twenty-four (12 neutered males and 12 intact females), healthy, adult cats weighing 4...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29351876/vital-signs-analysis-algorithm-detects-inflammatory-response-in-premature-infants-with-late-onset-sepsis-and-necrotizing-enterocolitis
#5
Leena B Mithal, Ram Yogev, Hannah L Palac, Daniel Kaminsky, Ilan Gur, Karen K Mestan
BACKGROUND: Nonspecific clinical signs and suboptimal diagnostic tests limit accurate identification of late onset sepsis (LOS) and necrotizing enterocolitis (NEC) in premature infants, resulting in significant morbidity and antibiotic overuse. An infant's systemic inflammatory response may be identified earlier than clinical suspicion through analysis of multiple vital signs by a computerized algorithm (RALIS). AIM: To evaluate the revised RALIS algorithm for detection of LOS and NEC in preterm infants...
January 16, 2018: Early Human Development
https://www.readbyqxmd.com/read/29351818/obstructive-sleep-apnea-in-patients-with-congenital-central-hypoventilation-syndrome-ventilated-by-diaphragm-pacing-without-tracheostomy
#6
Annie Wang, Sheila Kun, Bonnie Diep, Sally L Davidson Ward, Thomas G Keens, Iris A Perez
STUDY OBJECTIVES: To determine presence of obstructive sleep apnea (OSA) in patients with congenital central hypoventilation syndrome (CCHS) ventilated by diaphragm pacing (DP) without tracheostomy, and to determine if OSA can be improved by DP setting changes. METHODS: We reviewed polysomnography (PSG) results of 15 patients with CCHS from October 2001 to April 2014, age 15.4 ± 7.8 years, body mass index 22.0 ± 6.0 kg/m2, and 60% female. RESULTS: Of the 22 PSG results obtained for the 15 patients with CCHS, 9 were performed with tracheostomy capped, and 13 were performed after patients underwent decannulation...
January 16, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29351567/whole-thorax-irradiation-of-non-human-primates-induces-persistent-nuclear-damage-and-gene-expression-changes-in-peripheral-blood-cells
#7
Shanaz A Ghandhi, Helen C Turner, Igor Shuryak, Gregory O Dugan, J Daniel Bourland, John D Olson, Janet A Tooze, Shad R Morton, Ines Batinic-Haberle, J Mark Cline, Sally A Amundson
We investigated the cytogenetic and gene expression responses of peripheral blood cells of non-human primates (NHP, Macaca mulatta) that were whole-thorax irradiated with a single dose of 10 Gy. In this model, partial irradiation of NHPs in the thoracic region (Whole Thorax Lung Irradiation, WTLI) allows the study of late radiation-induced lung injury, while avoiding acute radiation syndromes related to hematopoietic and gastrointestinal injury. A transient drop in circulating lymphocytes and platelets was seen by 9 days, followed by elevations in respiratory rate, circulating neutrophils, lymphocytes, and monocytes at 60-100 days, corresponding to computed tomography (CT) and histologic evidence of pneumonitis, and elective euthanasia of four animals...
2018: PloS One
https://www.readbyqxmd.com/read/29351501/pediatric-anaphylaxis-in-the-prehospital-setting-incidence-characteristics-and-management
#8
Emily Andrew, Ziad Nehme, Stephen Bernard, Karen Smith
OBJECTIVE: Although hospital presentations for pediatric anaphylaxis have been described in the literature, a minimal amount is known regarding the incidence, characteristics, and management of pediatric anaphylaxis presenting to emergency medical services (EMS). METHODS: We performed a retrospective observational study of pediatrics (≤16 years) presenting to EMS in Victoria, Australia. Patients with suspected anaphylaxis were included if they were treated with epinephrine before or after EMS arrival...
January 19, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29351496/implementation-of-a-prehospital-protocol-change-for-asthmatic-children
#9
Anriada Nassif, Daniel G Ostermayer, Kim B Hoang, Mary K Claiborne, Elizabeth A Camp, Manish I Shah
BACKGROUND: Respiratory distress due to asthma is a common reason for pediatric emergency medical services (EMS) transports. Timely initiation of asthma treatment, including glucocorticoids, improves hospital outcomes. The impact of EMS-administered glucocorticoids on hospital-based outcomes for pediatric asthma patients is unknown. OBJECTIVE: The objective of this study was to evaluate the effect of an evidence-based pediatric EMS asthma protocol update, inclusive of oral glucocorticoid administration, on time to hospital discharge...
January 19, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29351331/the-association-between-previous-and-future-severe-exacerbations-of-chronic-obstructive-pulmonary-disease-updating-the-literature-using-robust-statistical-methodology
#10
Mohsen Sadatsafavi, Hui Xie, Mahyar Etminan, Kate Johnson, J Mark FitzGerald
BACKGROUND: There is minimal evidence on the extent to which the occurrence of a severe acute exacerbation of COPD that results in hospitalization affects the subsequent disease course. Previous studies on this topic did not generate causally-interpretable estimates. Our aim was to use corrected methodology to update previously reported estimates of the associations between previous and future exacerbations in these patients. METHODS: Using administrative health data in British Columbia, Canada (1997-2012), we constructed a cohort of patients with at least one severe exacerbation, defined as an episode of inpatient care with the main diagnosis of COPD based on international classification of diseases (ICD) codes...
2018: PloS One
https://www.readbyqxmd.com/read/29351330/use-of-influenza-antivirals-in-patients-hospitalized-in-hong-kong-2000-2015
#11
Benjamin J Cowling, Celine S L Chui, Wey Wen Lim, Peng Wu, Christopher K M Hui, J S Malik Peiris, Esther W Chan
OBJECTIVES: We aimed to describe patterns in the usage of antivirals to treat influenza virus infection in hospitals in Hong Kong from 2000 through 2015. METHODS: We analyzed centralized electronic health records that included dispensation information and diagnosis codes. Information collected on admissions included patient age, sex, admission year and month, and medications dispensed, and were matched with the first 15 discharge diagnosis codes. We divided monthly admission episodes by relevant population denominators to obtain admission rates, and stratified analyses by drug type, age group, and diagnosis codes...
2018: PloS One
https://www.readbyqxmd.com/read/29351160/acute-cardiorespiratory-and-metabolic-effects-of-a-sandbag-resistance-exercise-protocol
#12
Nicholas A Ratamess, Jie Kang, Jeremy D Kuper, Elizabeth A O'Grady, Nicole L Ellis, Ira T Vought, Emma Culleton, Jill A Bush, Avery D Faigenbaum
The purpose of the present study was to examine the acute cardiorespiratory and metabolic effects of a sandbag (SB) resistance exercise protocol and compare the responses to time-matched treadmill running protocols. Eight healthy, resistance-trained men (21.1 ± 1.0 years; 86.1 ± 7.8 kg) completed four protocols of equal duration in random sequence: 1) SB, 2) treadmill running at 60% of VO2 reserve (60VO2R), 3) treadmill running at 80% of VO2 reserve (80VO2R), and 4) a control protocol. The SB protocol was 16 min in duration and consisted of 3 circuits of 8 multiple-joint exercises (with 11-, 20-, or -48 kg sandbags) performed for as many repetitions as possible for 20 sec followed by a 10-sec rest interval prior to beginning the next exercise...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29350153/trends-in-infectious-disease-mortality-south-korea-1983-2015
#13
Young June Choe, Seung-Ah Choe, Sung-Il Cho
We used national statistics from 1983-2015 to evaluate trends in mortality caused by infectious diseases in South Korea. Age-standardized mortality from infectious disease decreased from 43.5/100,000 population in 1983 to 16.5/100,000 in 1996, and then increased to 44.6/100,000 in 2015. Tuberculosis was the most common cause of death in 1983 and respiratory tract infections in 2015. We observed a significant decline in infant deaths caused by infectious diseases, but mortality in persons age >65 years increased from 135 deaths/100,000 population in 1996 to 307/100,000 in 2015...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29350018/allergy-and-high-trait-anxiety-are-related-to-increases-in-heart-rate-variability-results-of-naturalistic-long-term-design-study
#14
J Rajcani, P Solarikova, I Brezina
A number of studies report heart rate variability (HRV) changes in allergic as well as high trait anxious people, and associations between allergic inflammation and trait anxiety. This study investigated HRV of 20 low anxious allergic, 19 healthy high trait anxious and 18 healthy low anxious, in naturalistic setting. On arranged research days, subjects performed measurements using portable ECG device and subjective self-assessment of perceived stress. Five repeated measurements data from each subject have shown increases in overall HRV, as well as HRV on respiratory frequencies in both allergy and high trait anxiety...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29348607/evaluation-of-mitochondrial-bioenergetics-dynamics-endoplasmic-reticulum-mitochondria-crosstalk-and-reactive-oxygen-species-in-fibroblasts-from-patients-with-complex-i-deficiency
#15
Guilhian Leipnitz, Al-Walid Mohsen, Anuradha Karunanidhi, Bianca Seminotti, Vera Y Roginskaya, Desiree M Markantone, Mateus Grings, Stephanie J Mihalik, Peter Wipf, Bennett Van Houten, Jerry Vockley
Mitochondrial complex I (CI) deficiency is the most frequent cause of oxidative phosphorylation (OXPHOS) disorders in humans. In order to benchmark the effects of CI deficiency on mitochondrial bioenergetics and dynamics, respiratory chain (RC) and endoplasmic reticulum (ER)-mitochondria communication, and superoxide production, fibroblasts from patients with mutations in the ND6, NDUFV1 or ACAD9 genes were analyzed. Fatty acid metabolism, basal and maximal respiration, mitochondrial membrane potential, and ATP levels were decreased...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348388/disseminated-histoplasmosis-in-an-indonesian-hiv-positive-patient-a-case-diagnosed-by-fine-needle-aspiration-cytology
#16
Nungki Anggorowati, Rita C Sulistyaningsih, Ahmad Ghozali, Yanri W Subronto
A 30-year-old Javanese-Indonesian man was admitted with complaints of 3 months persistent fever, weight loss, and fatigue. He had never known his past history of unprotected HIV until the admission. His only risk factor is unsafe sex. The patient seemed well nourished. Physical examination revealed blood pressure 100/60 mmHg, pulse 100 beats per minute, respiratory rate 20 times per minute, and temperature 38.8°C. Multiple cervical and inguinal lymphadenopathies were also found. Electrocardiogram showed anterolateral ischemic finding, whereas chest X-ray were normal...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29348183/neurophysiological-mechanisms-of-exertional-dyspnoea-in-fibrotic-interstitial-lung-disease
#17
Michele R Schaeffer, Christopher J Ryerson, Andrew H Ramsook, Yannick Molgat-Seon, Sabrina S Wilkie, Satvir S Dhillon, Reid A Mitchell, A William Sheel, Nasreen Khalil, Pat G Camp, Jordan A Guenette
Our understanding of the mechanisms of dyspnoea in fibrotic interstitial lung disease (ILD) is incomplete. The aims of this study were two-fold: 1) to determine whether dyspnoea intensity is better predicted by neural respiratory drive (NRD) or neuromechanical uncoupling (NMU) of the respiratory system in fibrotic ILD, and 2) to examine the effect of breathing 60% oxygen on NRD, NMU and dyspnoea ratings.Fourteen patients with fibrotic ILD were included. Visit 1 comprised a familiarisation incremental cycle exercise test, Visit 2 comprised a normoxic incremental cycling test to address Aim 1, and Visits 3 and 4 consisted of constant-load cycling while breathing room air or 60% oxygen to address Aim 2...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29346836/emergency-demand-repeat-and-frequent-presentations-by-older-patients-in-metropolitan-melbourne-a-retrospective-cohort-study-using-routinely-collected-hospital-data
#18
Judy Lowthian, Lyle Turner, Angela Joe, Christopher Pearce, Bianca Brijnath, Colette Browning, Marianne Shearer, Danielle Mazza
OBJECTIVE: To describe patterns for potentially avoidable general practice (PAGP)-type and non-PAGP-type ED presentations by older patients during 2008 and 2012. METHODS: Retrospective analysis of ED presentations by patients ≥70 years for 2008 and 2012. Metropolitan Melbourne public hospital data were obtained from the Victorian Emergency Minimum Dataset. Outcomes were characteristics of PAGP-type and non-PAGP-type presentations as defined by the Australian Institute of Health and Welfare; numbers and rates per 1000 population ≥70 years of repeat (×2-3/year) and frequent (≥ ×4/year) PAGP-type and non-PAGP-type presentations...
January 18, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29346225/validating-lung-models-using-the-asl-5000-breathing-simulator
#19
Amanda Dexter, Neil McNinch, Destiny Kaznoch, Teresa A Volsko
OBJECTIVE: This study sought to validate pediatric models with normal and altered pulmonary mechanics. METHODS: PubMed and CINAHL databases were searched for studies directly measuring pulmonary mechanics of healthy infants and children, infants with severe bronchopulmonary dysplasia and neuromuscular disease. The ASL 5000 was used to construct models using tidal volume (VT), inspiratory time (TI), respiratory rate, resistance, compliance, and esophageal pressure gleaned from literature...
January 17, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29345931/umbrella-sampling-and-x-ray-crystallographic-analysis-unveil-an-arg-asp-gate-facilitating-inhibitor-binding-inside-phosphopantetheine-adenylyltransferase-allosteric-cleft
#20
Abhisek Mondal, Rakesh Chatterjee, Saumen Datta
Phosphopantetheine adenylyltransferase (PPAT) is a rate limiting enzyme essential for biosynthesis of coenzyme A (CoA) which in turn is responsible to regulate the secretion of exotoxins via type III secretion system in Pseudomonas aeruginosa, causing severe health concerns ranging from nosocomial infections to respiratory failure. Acetyl Coenzyme A (AcCoA) is a newly reported inhibitor of PPAT, believed to regulate the cellular levels of CoA and thereby the pathogenesis. Very little is known so far regarding the mechanistic details of AcCoA binding inside PPAT binding cleft...
January 18, 2018: Journal of Physical Chemistry. B
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