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https://www.readbyqxmd.com/read/28515015/collateral-damage-and-the-criminalisation-of-drug-use
#1
Lisa Maher, Thomas Crewe Dixon
No abstract text is available yet for this article.
May 12, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28512170/deconstruction-of-interhospital-transfer-workflow-in-large-vessel-occlusion-real-world-data-in-the-thrombectomy-era
#2
Felix C Ng, Essie Low, Emily Andrew, Karen Smith, Bruce C V Campbell, Peter J Hand, Douglas E Crompton, Tissa Wijeratne, Helen M Dewey, Philip M Choi
BACKGROUND AND PURPOSE: Interhospital transfer is a critical component in the treatment of acute anterior circulation large vessel occlusive stroke transferred for mechanical thrombectomy. Real-world data for benchmarking and theoretical modeling are limited. We sought to characterize transfer workflow from primary stroke center (PSC) to comprehensive stroke center after the publication of positive thrombectomy trials. METHODS: Consecutive patients transferred from 3 high-volume PSCs to a single comprehensive stroke center between January 2015 and August 2016 were included in a retrospective study...
May 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28499679/aeromedical-ultrasound-the-evaluation-of-point-of-care-ultrasound-during-helicopter-transport
#3
Jeffrey G Yates, Denise Baylous
INTRODUCTION: This study correlated the eFAST findings performed in-flight by the flight crew with the findings obtained by the trauma team upon initial evaluation at a level 1 trauma center and with the subsequent CT scans that were performed or the surgeon's operative note. We hypothesize that aeromedical eFAST examinations are highly correlated with the trauma teams findings. METHODS: This prospective, observational study evaluated 190 traumatically injured patients from June 2014 to December 2015 in Southeast Virginia and Northeast North Carolina...
May 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28495841/lower-body-negative-pressure-decreases-non-invasively-measured-intracranial-pressure-and-internal-jugular-vein-cross-sectional-area-during-head-down-tilt
#4
William Watkins, Alan R Hargens, Shannon Baird, Erika Marie Clary, Brandon R Macias
INTRODUCTION: Long-term space flight induces a near visual acuity change in approximately 50% of astronauts. In some crew members, postflight cerebrospinal fluid (CSF) opening pressures by lumbar puncture are as high as 20.9 mmHg who demonstrated optic disc edema. CSF communicates through the cochlear aqueduct to affect perilymphatic pressure and tympanic membrane motion. We hypothesized that 50 mmHg of lower-body negative pressure (LBNP) during 15° head-down tilt (HDT) would mitigate elevations in internal jugular vein cross-sectional area (IJV CSA) and intracranial pressure (ICP)...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28492594/improving-patient-satisfaction-in-dermatology-a-prospective-study-of-an-urban-dermatology-clinic
#5
Adam V Sutton, Charles N Ellis, Samantha Spragg, Joe Thorpe, Kai-Ya Tsai, Sachi Patel, Katharine Ozeki, Ashley B Crew
Patient satisfaction has become an important measure of quality under the Patient Protection and Affordable Care Act. In this study, we assessed and analyzed patient satisfaction, nonattendance rates, and cycle times in an outpatient dermatology clinic. This study provides a snapshot of patient satisfaction in an urban dermatology clinic. Under the Patient Protection and Affordable Care Act, providers will be challenged to increase access to care and to validate quality of care through patient satisfaction.
April 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28492348/culture-of-human-cells-in-experimental-units-for-spaceflight-impacts-on-their-behavior
#6
Alessandra Cazzaniga, Claudia Moscheni, Jeanette Am Maier, Sara Castiglioni
Because space missions produce pathophysiological alterations such as cardiovascular disorders and bone demineralization which are very common on Earth, biomedical research in space is a frontier that holds important promises not only to counterbalance space-associated disorders in astronauts but also to ameliorate the health of Earth-bound population. Experiments in space are complex to design. Cells must be cultured in closed cell culture systems (from now defined experimental units (EUs)), which are biocompatible, functional, safe to minimize any potential hazard to the crew, and with a high degree of automation...
May 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28490255/developing-a-taxonomy-of-coordination-behaviors-in-nuclear-power-plant-control-rooms-during-emergencies
#7
Dunxing Wang, Qin Gao, Zhizhong Li, Fei Song, Liang Ma
This study aims to develop a taxonomy of coordination behaviors during emergencies in nuclear power plants (NPPs). We summarized basic coordination behaviors from literature in aviation, healthcare, and nuclear field and identified coordination behaviors specific to the nuclear domain by interviewing and surveying control crew operators. The established taxonomy includes seven workflow stages and 24 basic coordination behaviors. To evaluate the reliability and feasibility of the taxonomy, we analyzed 12 videos of operators' training sessions by coding coordination behaviors with the taxonomy and the inter-rater reliability was acceptable...
May 10, 2017: Ergonomics
https://www.readbyqxmd.com/read/28486129/the-canonical-notch-signaling-pathway-structural-and-biochemical-insights-into-shape-sugar-and-force
#8
REVIEW
Rhett A Kovall, Brian Gebelein, David Sprinzak, Raphael Kopan
The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activity and half-life. Herein we provide a review of recent molecular insights into how Notch signals are triggered and how cell shape affects these events, and we use the new insights to illuminate a few perplexing observations...
May 8, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28484734/comparative-quality-assessment-of-esophageal-examination-with-transnasal-and-sedated-endoscopy
#9
Nicholas R Crews, Emmanuel C Gorospe, Michele L Johnson, Louis-Michel Wong Kee Song, David A Katzka, Prasad G Iyer
Background Unsedated transnasal esophagoscopy (TNE) may offer a less expensive, mobile alternative to sedated esophagogastroduodenoscopy (EGD) for evaluations of reflux related complications. Comparisons of imaging quality by these methods are lacking. Methods Two reviewers evaluated videos of TNE and EGD procedures, performed during a community randomized study comparing endoscopic techniques. Subjects were randomized to EGD, TNE in endoscopy suite, or TNE in mobile research unit. Endoscopic quality was assessed using a validated scoring tool...
May 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28481748/lessons-from-crew-resource-management-for-cardiac-surgeons
#10
Patrick Marvil, Curt Tribble
Crew resource management (CRM) describes a system developed in the late 1970s in response to a series of deadly commercial aviation crashes. This system has been universally adopted in commercial and military aviation and is now an integral part of aviation culture. CRM is an error mitigation strategy developed to reduce human error in situations in which teams operate in complex, high-stakes environments. Over time, the principles of this system have been applied and utilized in other environments, particularly in medical areas dealing with high-stakes outcomes requiring optimal teamwork and communication...
April 30, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/28473515/-our-care-through-our-eyes-impact-of-a-co-produced-digital-educational-programme-on-nurses-knowledge-confidence-and-attitudes-in-providing-care-for-children-and-young-people-who-have-self-harmed-a-mixed-methods-study-in-the-uk
#11
Joseph C Manning, Tim Carter, Asam Latif, Angela Horsley, Joanne Cooper, Marie Armstrong, Jamie Crew, Damian Wood, Patrick Callaghan, Heather Wharrad
OBJECTIVES: (1) To determine the impact of a digital educational intervention on the knowledge, attitudes, confidence and behavioural intention of registered children's nurses working with children and young people (CYP) admitted with self-harm.(2) To explore the perceived impact, suitability and usefulness of the intervention. INTERVENTION: A digital educational intervention that had been co-produced with CYP service users, registered children's nurses and academics...
May 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28467438/frail-or-hale-skeletal-frailty-indices-in-medieval-london-skeletons
#12
Kathryn E Marklein, Douglas E Crews
To broaden bioarchaeological applicability of skeletal frailty indices (SFIs) and increase sample size, we propose indices with fewer biomarkers (2-11 non-metric biomarkers) and compare these reduced biomarker SFIs to the original metric/non-metric 13-biomarker SFI. From the 2-11-biomarker SFIs, we choose the index with the fewest biomarkers (6-biomarker SFI), which still maintains the statistical robusticity of a 13-biomarker SFI, and apply this index to the same Medieval monastic and nonmonastic populations, albeit with an increased sample size...
2017: PloS One
https://www.readbyqxmd.com/read/28463042/defining-components-of-team-leadership-and-membership-in-prehospital-emergency-medical-services
#13
Remle P Crowe, Robert L Wagoner, Severo A Rodriguez, Melissa A Bentley, David Page
BACKGROUND: Teamwork is critical for patient and provider safety in high-stakes environments, including the setting of prehospital emergency medical services (EMS). OBJECTIVE: We sought to describe the components of team leadership and team membership on a single patient call where multiple EMS providers are present. METHODS: We conducted a two-day focus group with nine subject matter experts in crew resource management (CRM) and EMS using a structured nominal group technique (NGT)...
May 2, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28446593/creating-cell-type-specific-mutants-by-enhancer-mutagenesis
#14
Stephen Crews
Cell signaling plays an essential role in development, and knowledge of the identities of the cells sending the signal is critical. This can be a challenge, since signaling pathways and ligands are commonly used at multiple times and in multiple cell types during development. One solution to this problem is to create cell type-specific mutants using CRISPR/Cas9 to mutate enhancers that control different patterns of expression. In this issue of Genes & Development, Rogers and colleagues (pp. 634-638) provide the first use of this method in Drosophila to solve a long-standing issue in patterning of the embryonic central nervous system...
April 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28445889/genetic-polymorphisms-in-aromatase-cyp19a1-are-not-associated-with-gonadal-phenotypes-in-red-eared-slider-turtle-hatchlings-developed-at-a-pivotal-temperature
#15
Yuiko Matsumoto, David Crews
Embryonic gonad sex in many reptilian species is determined by the incubation temperature of the egg, a differentiation process known as temperature-dependent sex determination (TSD). Incubation at the pivotal temperature (PvT) results in approximately an equal number of offspring of both sexes. We investigated the potential contribution of genetic variations that drives the gonadal differentiation into testes or ovaries under this temperature in the red-eared slider turtle (Trachemys scripta). Four male and 4 female hatchlings of eggs that had been incubated at the PvT were examined for polymorphisms at an approximately 23-kb region of the aromatase (cyp19a1) gene...
April 27, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/28445210/perceived-discrimination-and-longitudinal-change-in-kidney-function-among-urban-adults
#16
May A Beydoun, Angedith Poggi-Burke, Alan B Zonderman, Ola S Rostant, Michele K Evans, Deidra C Crews
OBJECTIVE: Perceived discrimination has been associated with psychosocial distress and adverse health outcomes. We examined associations of perceived discrimination measures with changes in kidney function in a prospective cohort study, the Healthy Aging in Neighborhoods of Diversity Across the LifeSpan. METHODS: Our study included 1,620 participants with preserved baseline kidney function (estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73m) (662 Whites and 958 African-Americans (AA), aged 30-64 years)...
April 26, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28435494/the-efficacy-of-lucas-in-prehospital-cardiac-arrest-scenarios-a-crossover-mannequin-study
#17
Robert A Gyory, Scott E Buchle, David Rodgers, Jeffrey S Lubin
INTRODUCTION: High-quality cardiopulmonary resuscitation (CPR) is critical for successful cardiac arrest outcomes. Mechanical devices may improve CPR quality. We simulated a prehospital cardiac arrest, including patient transport, and compared the performance of the LUCAS™ device, a mechanical chest compression-decompression system, to manual CPR. We hypothesized that because of the movement involved in transporting the patient, LUCAS would provide chest compressions more consistent with high-quality CPR guidelines...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28427424/microglial-depletion-alters-the-brain-neuroimmune-response-to-acute-binge-ethanol-withdrawal
#18
T Jordan Walter, Fulton T Crews
BACKGROUND: Recent studies have implicated microglia-the resident immune cells of the brain-in the pathophysiology of alcoholism. Indeed, post-mortem alcoholic brains show increased microglial markers and increased immune gene expression; however, the effects of ethanol on microglial functioning and how this impacts the brain remain unclear. In this present study, we investigate the effects of acute binge ethanol on microglia and how microglial depletion changes the brain neuroimmune response to acute binge ethanol withdrawal...
April 20, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28426257/facial-eschar-following-a-single-application-of-black-salve
#19
Dayne Laskey, Midori Tran
A previously healthy 86-year-old male was transported by ambulance to the trauma bay of the emergency department (ED) for profuse bleeding from the left temple. The ambulance crew raised concern that the volume and force of the bleed may suggest arterial involvement. The patient reported having applied a natural topical remedy to a mole two weeks prior at the recommendation of a naturopath. The patient described progressive blackening and swelling of the area in the days following the single application of the product...
April 20, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28420688/can-a-partnership-between-general-practitioners-and-ambulance-services-reduce-conveyance-to-emergency-care
#20
Manuel Villarreal, Jonathan Leach, Kandala Ngianga-Bakwin, Jeremy Dale
BACKGROUND: Emergency services are facing increasing workload pressures, and new models of care are needed. We evaluate the impact of a service development involving a partnership between emergency ambulance crews and general practitioners (GPs) on reducing conveyance rates to the Hospital Emergency Department (ED). METHODS: The service model was implemented in the West Midlands of England. Call handlers identified patients with needs that could be addressed by a GP using locally agreed criteria...
April 18, 2017: Emergency Medicine Journal: EMJ
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