keyword
MENU ▼
Read by QxMD icon Read
search

Crew

keyword
https://www.readbyqxmd.com/read/29144750/investigation-of-the-physical-and-bioactive-properties-of-bromo-and-iodo-containing-sponge-derived-compounds-possessing-an-oxyphenylethanamine-core
#1
Erin P McCauley, Hanh Lam, Nicholas Lorig-Roach, Justin Luu, Cameron Lloyd, Karen Tenney, Halina Pietraszkiewicz, Cristina Diaz, Frederick A Valeriote, Victoria Auerbuch, Phillip Crews
This research set out to identify compounds from marine sponges that can act as bacterial virulence blockers. Extracts from a total of 80 sponges collected from throughout Indonesia were screened in a high-throughput NF-κB-based screen that identifies compounds capable of inhibiting the bacterial type III secretion system (T3SS) in Yersinia pseudotuberculosis. An extract that was shown to inhibit T3SS-driven NF-κB expression was obtained from an Iotrochota cf. iota sponge and was the source of seven new bromo- and iodo-containing compounds, all of which contain a 2-(4-oxyphenyl)ethan-1-amine core...
November 16, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29136391/effects-of-1-h-16-o-charged-particle-irradiation-on-short-term-memory-and-hippocampal-physiology-in-a-murine-model
#2
Frederico Kiffer, Hannah Carr, Thomas Groves, Julie E Anderson, Tyler Alexander, Jing Wang, John W Seawright, Vijayalakshmi Sridharan, Gwendolyn Carter, Marjan Boerma, Antiño R Allen
Radiation from galactic cosmic rays (GCR) poses a significant health risk for deep-space flight crews. GCR are unique in their extremely high-energy particles. With current spacecraft shielding technology, some of the predominant particles astronauts would be exposed to are (1)H + (16)O. Radiation has been shown to cause cognitive deficits in mice. The hippocampus plays a key role in memory and cognitive tasks; it receives information from the cortex, undergoes dendritic-dependent processing and then relays information back to the cortex...
November 14, 2017: Radiation Research
https://www.readbyqxmd.com/read/29129718/lessons-in-protac-design-from-selective-degradation-with-a-promiscuous-warhead
#3
Daniel P Bondeson, Blake E Smith, George M Burslem, Alexandru D Buhimschi, John Hines, Saul Jaime-Figueroa, Jing Wang, Brian D Hamman, Alexey Ishchenko, Craig M Crews
Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we report a previously understudied benefit of small molecule proteolysis-targeting chimeras (PROTACs) that recruit E3 ubiquitin ligases to target proteins for their ubiquitination and subsequent proteasome-mediated degradation. Using promiscuous CRBN- and VHL-recruiting PROTACs that bind >50 kinases, we show that only a subset of bound targets is degraded. The basis of this selectivity relies on protein-protein interactions between the E3 ubiquitin ligase and the target protein, as illustrated by engaged proteins that are not degraded as a result of unstable ternary complexes with PROTAC-recruited E3 ligases...
November 9, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29129716/the-advantages-of-targeted-protein-degradation-over-inhibition-an-rtk-case-study
#4
George M Burslem, Blake E Smith, Ashton C Lai, Saul Jaime-Figueroa, Daniel C McQuaid, Daniel P Bondeson, Momar Toure, Hanqing Dong, Yimin Qian, Jing Wang, Andrew P Crew, John Hines, Craig M Crews
Proteolysis targeting chimera (PROTAC) technology has emerged over the last two decades as a powerful tool for targeted degradation of endogenous proteins. Herein we describe the development of PROTACs for receptor tyrosine kinases, a protein family yet to be targeted for induced protein degradation. The use of VHL-recruiting PROTACs against this protein family reveals several advantages of degradation over inhibition alone: direct comparisons of fully functional, target-degrading PROTACs with target-inhibiting variants that contain an inactivated E3 ligase-recruiting ligand show that degradation leads to more potent inhibition of cell proliferation and a more durable and sustained downstream signaling response, and thus addresses the kinome rewiring challenge seen with many receptor tyrosine kinase inhibitors...
October 25, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29126483/multi-parametric-polymer-based-potentiometric-analytical-microsystem-for-future-manned-space-missions
#5
Antonio Calvo-López, Mar Puyol, Joan Manel Casalta, Julián Alonso-Chamarro
The construction and evaluation of a Cyclic Olefin Copolymer (COC)-based continuous flow potentiometric microanalyzer to simultaneously monitor potassium, chloride and nitrate ions in samples from an on-board water recycling process expected to be installed in future manned space missions is presented. The main goals accomplished in this work address the specific required characteristics for a miniaturized on-line monitoring system to control water quality in such missions. To begin with, the integration of three ion-selective electrodes (ISEs) and a reference electrode in a compact microfluidic platform that incorporates a simple automatic autocalibration process allows obtaining information about the concentration of the three ions with optimal analytical response characteristics, but moreover with low reagents consumption and therefore with few waste generation, which is critical for this specific application...
December 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29123877/performance-review-of-regional-emergency-medical-service-pre-arrival-cardiopulmonary-resuscitation-with-or-without-dispatcher-instruction-a-population-based-observational-study
#6
Hidetada Fukushima, Yasuyuki Kawai, Hideki Asai, Tadahiko Seki, Kazunobu Norimoto, Yasuyuki Urisono, Kazuo Okuchi
Background: To investigate variations in emergency medical service (EMS) pre-arrival cardiopulmonary resuscitation (CPR), including both bystander CPR without dispatch assistance and dispatch-assisted CPR (DACPR). Methods: We carried out an observational study by implementing EMS pre-arrival CPR reports in three fire agencies. We included adult, non-traumatic, and non-EMS witnessed out-of-hospital cardiac arrests. This reporting system comprised the dispatch instruction process and bystander CPR quality based on evaluations by EMS crews who arrived on the scene...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122202/human-responses-to-wave-slamming-vibration-on-a-polar-supply-and-research-vessel
#7
H Omer, A Bekker
A polar supply and research vessel is pre-disposed to wave slamming which has caused complaints among crew and researchers regarding interference with sleep, equipment use and research activities. The present work undertook to survey passenger claims of sleep interference, disturbed motor tasks and equipment damage as a result of wave slamming during normal operations of this vessel. The hypothesis was investigated that whole-body vibration metrics from ISO 2631-1 are potentially suitable for the prediction of human slamming complaints...
February 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29120515/the-effects-of-crew-resource-management-on-teamwork-and-safety-climate-at-veterans-health-administration-facilities
#8
Miriam E Schwartz, Deborah E Welsh, Douglas E Paull, Regina S Knowles, Lori D DeLeeuw, Robin R Hemphill, Keith E Essen, Gary L Sculli
Communication failure is a significant source of adverse events in health care and a leading root cause of sentinel events reported to the Joint Commission. The Veterans Health Administration National Center for Patient Safety established Clinical Team Training (CTT) as a comprehensive program to enhance patient safety and to improve communication and teamwork among health care professionals. CTT is based on techniques used in aviation's Crew Resource Management (CRM) training. The aviation industry has reached a significant safety record in large part related to the culture change generated by CRM and sustained by its recurrent implementation...
November 9, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29117128/bioactive-secondary-metabolites-from-the-marine-sponge-genus-agelas
#9
REVIEW
Huawei Zhang, Menglian Dong, Jianwei Chen, Hong Wang, Karen Tenney, Phillip Crews
The marine sponge genus Agelas comprises a rich reservoir of species and natural products with diverse chemical structures and biological properties with potential application in new drug development. This review for the first time summarized secondary metabolites from Agelas sponges discovered in the past 47 years together with their bioactive effects.
November 8, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29116818/pure-and-oxidized-copper-materials-as-potential-antimicrobial-surfaces-for-spaceflight-activities
#10
C Hahn, M Hans, C Hein, R L Mancinelli, F Mücklich, R Wirth, P Rettberg, C E Hellweg, R Moeller
Microbial biofilms can lead to persistent infections and degrade a variety of materials, and they are notorious for their persistence and resistance to eradication. During long-duration space missions, microbial biofilms present a danger to crew health and spacecraft integrity. The use of antimicrobial surfaces provides an alternative strategy for inhibiting microbial growth and biofilm formation to conventional cleaning procedures and the use of disinfectants. Antimicrobial surfaces contain organic or inorganic compounds, such as antimicrobial peptides or copper and silver, that inhibit microbial growth...
November 8, 2017: Astrobiology
https://www.readbyqxmd.com/read/29105064/outcomes-after-cancelled-helicopter-emergency-medical-service-missions-due-to-concurrencies-a-retrospective-cohort-study
#11
Ø Østerås, J-K Heltne, K Tønsager, G Brattebø
BACKGROUND: Appropriate dispatch criteria and helicopter emergency medical service (HEMS) crew decisions are crucial for avoiding over-triage and reducing the number of concurrencies. The aim of the present study was to compare patient outcomes after completed HEMS missions and missions cancelled by the HEMS due to concurrencies. METHODS: Missions cancelled due to concurrencies (AMB group) and completed HEMS missions (HEMS group) in Western Norway from 2004 to 2013 were assessed...
November 3, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29102800/hmgb1-il-1%C3%AE-complexes-regulate-neuroimmune-responses-in-alcoholism
#12
Leon G Coleman, Jian Zou, Liya Qin, Fulton T Crews
Neuroimmune activation is a key feature of the pathologies of numerous psychiatric disorders including alcoholism, depression, and anxiety. Both HMGB1 and IL-1β have been implicated in brain disorders. Previous studies find HMGB1 andIL-1β form heterocomplexes in vitro with enhanced immune responses, lead to our hypothesis that HMGB1 and IL-1β heterocomplexes formed in vivo to contribute to the pathology of alcoholism. HMGB1/IL-1β heterocomplexes were prepared in vitro and found to potentiate IL-1β receptor proinflammatory gene induction compared to IL-1β alone in hippocampal brain slice culture...
November 1, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29095286/clinical-predictors-of-outcomes-in-patients-undergoing-emergency-air-medical-transport-from-kinmen-to-taiwan
#13
Julia Chia-Yu Chang, Hsien-Hao Huang, Shu-Hua Chang, Yin-Ru Chen, Ju-Shin Fan, Yen-Chia Chen, David Hung-Tsang Yen
Emergency air medical transport (EAMT) is indispensable for acutely or critically ill patients in remote areas. We determined patient-level and transport-specific factors associated with all-cause mortality after EAMT.We conducted a population-based, retrospective cohort study using a prospective registry consisting of clinical/medical records. Study inclusion criteria consisted of all adults undergoing EAMT from Kinmen hospital to the ED of Taipei Veterans General Hospital (TVGH) between January 1, 2006 and December 31, 2012...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29094430/social-support-following-diagnosis-and-treatment-for-colorectal-cancer-and-associations-with-health-related-quality-of-life-results-from-the-uk-colorectal-wellbeing-crew-cohort-study
#14
Joanne Haviland, Samantha Sodergren, Lynn Calman, Jessica Corner, Amy Din, Deborah Fenlon, Chloe Grimmett, Alison Richardson, Peter W Smith, Jane Winter, Claire Foster
OBJECTIVE: Social support is acknowledged as important in cancer survivorship, but little is known about change in support after cancer diagnosis and factors associated with this, particularly in colorectal cancer. The CREW cohort study investigated social support up to 2 years following curative intent surgery for colorectal cancer. METHODS: A total of 871 adults recruited pre-treatment from 29 UK centres 2010 to 2012 consented to follow-up. Questionnaires at baseline, 3, 9, 15, and 24 months post-surgery included assessments of social support (Medical Outcomes Study-Social Support Survey, MOS-SSS) and health-related quality of life (HRQoL)...
November 1, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29093364/mercury-poisoning-in-a-fisherman-working-on-a-pelagic-fishing-vessel-due-to-excessive-tuna-consumption
#15
Ji-Sung Ahn, Kyung Wook Kang, Won-Yang Kang, Hyeong-Min Lim, Seunghyeon Cho, Jai-Dong Moon, Won-Ju Park
OBJECTIVE: To report the case of a fisherman who developed chronic mercury poisoning due to excessive consumption of tuna while working on a pelagic fishing vessel. CASE REPORT: A 48-year-old male deep-sea fisherman developed paresthesia and pain in both legs while working at sea. He continued working for over 4 months on a pelagic fishing vessel but was eventually unable to function normally as his condition deteriorated. Upon arrival on land, he received specialist treatment, including imaging studies, for 2 months; however, the cause of the symptoms was not identified...
November 1, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29083461/development-of-a-virtual-crew-resource-management-training-program-to-improve-communication
#16
Dana Tschannen
Crew Resource Management (CRM), a method focused on the management of human error and risk reduction, has shown promise in reducing communication failure in health care. The purpose of this project was to develop a virtual training program in CRM principles of effective leadership and followership, and evaluate the applicability to nurses working in the hospital setting. The intervention included the development of a virtual CRM training program consisting of a self-learning module and virtual simulation. Beta testing of the module was conducted by six nurses, followed by an evaluation of the training program by nurses (n = 5) in a general medicine department...
November 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/29078292/early-rearing-history-influences-oxytocin-receptor-epigenetic-regulation-in-rhesus-macaques
#17
Maggie Baker, Stephen G Lindell, Carlos A Driscoll, Zhifeng Zhou, Qiaoping Yuan, Melanie L Schwandt, Isaac Miller-Crews, Elizabeth A Simpson, Annika Paukner, Pier Francesco Ferrari, Ravi Kumar Sindhu, Muslima Razaqyar, Wolfgang H Sommer, Juan F Lopez, Robert C Thompson, David Goldman, Markus Heilig, J Dee Higley, Stephen J Suomi, Christina S Barr
Adaptations to stress can occur through epigenetic processes and may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n = 13). Focusing on genes with roles in stress response and behavior, we assessed the effects of rearing on H3K4me3 binding by ANOVA. We found decreased H3K4me3 binding at genes critical to behavioral stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a corresponding decrease in RNA expression...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29072311/modifications-of-the-national-early-warning-score-for-patients-with-chronic-respiratory-disease
#18
N E Pedersen, L S Rasmussen, J A Petersen, T A Gerds, D Østergaard, A Lippert
BACKGROUND: The National Early Warning Score (NEWS) uses physiological variables to detect deterioration in hospitalized patients. However, patients with chronic respiratory disease may have abnormal variables not requiring interventions. We studied how the Capital Region of Denmark NEWS Override System (CROS), the Chronic Respiratory Early Warning Score (CREWS) and the Salford NEWS (S-NEWS) affected NEWS total scores and NEWS performance. METHODS: In an observational study, we included patients with chronic respiratory disease...
October 26, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29060764/how-the-workload-impacts-on-cognitive-cooperation-a-pilot-study
#19
Nicolina Sciaraffa, Gianluca Borghini, Pietro Arico, Gianluca Di Flumeri, Jlenia Toppi, Alfredo Colosimo, Anastatios Bezerianos, Nitish V Thakor, Fabio Babiloni
Cooperation degradation can be seen as one of the main causes of human errors. Poor cooperation could arise from aberrant mental processes, such as mental overload, that negatively affect the user's performance. Using different levels of difficulty in a cooperative task, we combined behavioural, subjective and neurophysiological data with the aim to i) quantify the mental workload under which the crew was operating, ii) evaluate the degree of their cooperation, and iii) assess the impact of the workload demands on the cooperation levels...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29053941/a-point-source-outbreak-of-coccidioidomycosis-among-a-highway-construction-crew
#20
Mark Nicas
Coccidioidomycosis is an infection caused by inhaling spores of the soil fungus Coccidioides immitis (hereafter termed Cocci). Cocci is endemic in certain areas of California. When soil containing the fungus is disturbed, as during earth-moving activities, respirable Cocci spores can become airborne and be inhaled by persons in the vicinity. This paper describes a cluster of seven Cocciodioidomycosis cases among a highway construction crew that occurred in June/July 2008 in Kern County, CA, which is among the most highly endemic regions for Cocci in California...
October 20, 2017: Journal of Occupational and Environmental Hygiene
keyword
keyword
42278
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"