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https://www.readbyqxmd.com/read/29785343/perinatal-specimens-of-maiasaura-from-the-upper-cretaceous-of-montana-usa-insights-into-the-early-ontogeny-of-saurolophine-hadrosaurid-dinosaurs
#1
Albert Prieto-Marquez, Merrilee F Guenther
Perinatal specimens of hadrosaurids discovered in the late 1970's by field crews from Princeton University were significant in providing evidence of the early ontogenetic stages in North American dinosaurs. These specimens from the Campanian (Upper Cretaceous) Two Medicine Formation of Montana consist of over a dozen skeletons referable to the saurolophine hadrosaurid Maiasaura peeblesorum , but never fully figured or described. Here, we provide a more complete documentation of the morphology of these specimens, along with an examination of variation during a large span of the development of saurolophine hadrosaurids...
2018: PeerJ
https://www.readbyqxmd.com/read/29776997/turning-workers-into-false-queens-the-role-of-exogenous-pheromones-in-regulating-reproduction-in-worker-honey-bees
#2
Abdullahi A Yusuf, Robin M Crewe, Christian W W Pirk
One of the responses that honey bee workers can make in the event of queen loss is to develop into false queens. False queens are workers that exhibit both behavioural and physiological traits similar to those of a true queen. However, the presence of more than one false queen in a colony distorts the established hierarchies. As transformation into a false queen occurs after emergence as an adult, we tested the effect of worker mobile pheromone carriers (PCs) treated with exogenously supplied pheromones on their nestmates...
May 18, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29773139/systemic-humoral-immunity-in-beef-bulls-following-therapeutic-vaccination-against-tritrichomonas-foetus
#3
Christopher Alling, D Owen Rae, Xiaojie Ma, Laura Neumann, L Gene Lollis, Elizabeth Steele, John Yelvington, Hemant K Naikare, Heather Stockdale Walden, John Crews, Raoul Boughton
The utility of therapeutic vaccination of bulls against Tritrichomonas foetus has been advocated in previous studies, but anecdotal reports suggest this practice does not clear infections and may additionally confound diagnostic testing by reducing parasite burdens below detectable limits. The objective of this study was to characterize the systemic humoral immune response to therapeutic vaccination in T. foetus-infected bulls over a period of four months using an indirect ELISA and to compare the dynamics of this response to culture and PCR results to establish the existence of a relationship (or lack thereof) between immunization and infection status...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772877/report-back-for-geo-referenced-environmental-data-a-case-study-on-personal-monitoring-of-temperature-in-outdoor-workers
#4
Laura Thompson, Maggie Sugg, Jennifer Runkle
Few studies have evaluated the benefits of reporting back participatory environmental monitoring results, particularly regarding participant motivation toward behavioural modification concerning workplace heat exposure. This study evaluated the individual data report-back for geo-located environmental temperature and time activity patterns in grounds maintenance crews in three geographic regions across the South-eastern United States. Surveys collected information on worker interpretation of their results and intended action(s) to reduce heat exposure...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29761750/obesity-disrupts-rhythmic-clock-gene-expression-in-maternal-adipose-tissue-during-rat-pregnancy
#5
Rachael C Crew, Peter J Mark, Brendan J Waddell
Obesity during pregnancy causes numerous maternal and fetal health complications, but the underlying mechanisms remain unclear. Adipose tissue dysfunction in obesity has previously been linked to disruption of the intrinsic adipose clock gene network that is crucial for normal metabolic function. This adipose clock also undergoes major change as part of the maternal metabolic adaptation to pregnancy, but whether this is affected by maternal obesity is unknown. Consequently, in this study we tested the hypothesis that obesity disturbs rhythmic gene expression in maternal adipose tissue across pregnancy...
June 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29753536/wasp-write-a-scientific-paper-doctors-in-star-trek-correctly-compassionate-caring-kantian-zampolit
#6
Victor Grech, Elizabeth Grech, Jason T Eberl
Doctors in Star Trek are vital and central characters, often crucial in helping their captains to reach command decisions. They are also interdisciplinarians, performing not only medical tasks but also any form of work related to all fields of biology. Furthermore, these doctors also carry out any required research that pertains to the biological sciences. It is perhaps this unique blend of skills, combined with a fundamental orientation towards humanism and compassion, that leads to their default position, de facto, if not de jure, as the crew's ethics officers, a role that they embrace with as much dedication and zeal as the former Soviet communist political officers/commissars (the Zampolit) did theirs...
May 9, 2018: Early Human Development
https://www.readbyqxmd.com/read/29753414/late-effects-of-1-h-irradiation-on-hippocampal-physiology
#7
Frederico Kiffer, Alexis K Howe, Hannah Carr, Jing Wang, Tyler Alexander, Julie E Anderson, Thomas Groves, John W Seawright, Vijayalakshmi Sridharan, Gwendolyn Carter, Marjan Boerma, Antiño R Allen
NASA's Missions to Mars and beyond will expose flight crews to potentially dangerous levels of charged-particle radiation. Of all charged nuclei, 1 H is the most abundant charged particle in both the galactic cosmic ray (GCR) and solar particle event (SPE) spectra. There are currently no functional spacecraft shielding materials that are able to mitigate the charged-particle radiation encountered in space. Recent studies have demonstrated cognitive injuries due to high-dose 1 H exposures in rodents. Our study investigated the effects of 1 H irradiation on neuronal morphology in the hippocampus of adult male mice...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29753411/solar-particle-event-storm-shelter-requirements-for-missions-beyond-low-earth-orbit
#8
REVIEW
L W Townsend, J H Adams, S R Blattnig, M S Clowdsley, D J Fry, I Jun, C D McLeod, J I Minow, D F Moore, J W Norbury, R B Norman, D V Reames, N A Schwadron, E J Semones, R C Singleterry, T C Slaba, C M Werneth, M A Xapsos
Protecting spacecraft crews from energetic space radiations that pose both chronic and acute health risks is a critical issue for future missions beyond low Earth orbit (LEO). Chronic health risks are possible from both galactic cosmic ray and solar energetic particle event (SPE) exposures. However, SPE exposures also can pose significant short term risks including, if dose levels are high enough, acute radiation syndrome effects that can be mission- or life-threatening. In order to address the reduction of short term risks to spaceflight crews from SPEs, we have developed recommendations to NASA for a design-standard SPE to be used as the basis for evaluating the adequacy of proposed radiation shelters for cislunar missions beyond LEO...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29753408/a-urine-fuelled-soil-based-bioregenerative-life-support-system-for-long-term-and-long-distance-manned-space-missions
#9
Federico Maggi, Fiona H M Tang, Céline Pallud, Chuanhui Gu
A soil-based cropping unit fuelled with human urine for long-term manned space missions was investigated with the aim to analyze whether a closed-loop nutrient cycle from human liquid wastes was achievable. Its ecohydrology and biogeochemistry were analysed in microgravity with the use of an advanced computational tool. Urine from the crew was used to supply primary (N, P, and K) and secondary (S, Ca and Mg) nutrients to wheat and soybean plants in the controlled cropping unit. Breakdown of urine compounds into primary and secondary nutrients as well as byproduct gases, adsorbed, and uptake fractions were tracked over a period of 20 years...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29750057/medical-issues-in-flight-and-updating-the-emergency-medical-kit
#10
REVIEW
Mohamud A Verjee, Robert Crone, Grigory Ostrovskiy
Airline travel is more affordable than ever and likely safer than ever too. Within half a day, a passenger can be on the other side of the world. However, medical care in-flight has been an issue for those with medical conditions and for those who fall sick during a journey. While airlines have the advice of multiple recognized organizations on needs and standards of care, in-flight emergencies occur at various levels. An emergency medical kit (EMK) together with trained cabin crew can be very effective at resolving the minor problems that arise and reducing the risk of escalation...
2018: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/29746855/the-first-multi-zoo-application-of-an-allostatic-load-index-to-western-lowland-gorillas-gorilla-gorilla-gorilla
#11
Ashley N Edes, Barbara A Wolfe, Douglas E Crews
Vertebrate stress responses are highly adaptive biological functions, maximizing survival probability in life-threatening situations. However, experiencing repeated and/or chronic stressors can generate physiological dysregulation and lead to disease. Because stress responses are multi-systemic and involve a wide range of physiological functions, identifying responses to stressors is best accomplished using integrated biomarker models. Allostatic load, defined as the physiological dysregulation that accumulates over the lifespan due to stressful experiences, is one such model...
May 7, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29745923/bcg-therapy-in-nmibc-how-much-and-for-how-long
#12
Annelisse Ashton, Venkata Ramana Murthy Kusuma, Jeremy Crew, A Hugh Mostafid
Since its introduction in 1976 Bacille Calmette- Guerin (BCG) has become the standard of care in high risk non-muscle-invasive bladder cancer (NMIBC). Despite more than 40 years of experience, we do not know the most optimal BCG dose to maximize effectiveness whilst minimizing side effects. There is universal agreement that an initial induction course of BCG should consist of 6 weekly instillations if tolerated. However, with regards to the actual dose, data on the comparative effectiveness of one third dose versus full dose BCG is inconclusive...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29743777/implication-of-emotional-labor-cognitive-flexibility-and-relational-energy-among-cabin-crew-a-review
#13
REVIEW
Rithi Baruah, K Jayasankara Reddy
The primary aim of the civil aviation industry is to provide a secured and comfortable service to their customers and clients. This review concentrates on the cabin crew members, who are the frontline employees of the aviation industry and are salaried to smile. The objective of this review article is to analyze the variables of emotional labor, cognitive flexibility, and relational energy using the biopsychosocial model and identify organizational implications among cabin crew. Online databases such as EBSCOhost, JSTOR, Springerlink, and PubMed were used to gather articles for the review...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29736694/pre-surgical-trial-of-the-akt-inhibitor-mk-2206-in-patients-with-operable-invasive-breast-cancer-a-new-york-cancer-consortium-trial
#14
K Kalinsky, J A Sparano, X Zhong, E Andreopoulou, B Taback, L Wiechmann, S M Feldman, P Ananthakrishnan, A Ahmad, S Cremers, A N Sireci, J R Cross, D K Marks, P Mundi, E Connolly, K D Crew, M A Maurer, H Hibshoosh, S Lee, D L Hershman
INTRODUCTION: The PI3K/AKT/mTOR pathway is an oncogenic driver in breast cancer (BC). In this multi-center, pre-surgical study, we evaluated the tissue effects of the AKT inhibitor MK-2206 in women with stage I-III BC. MATERIALS AND METHODS: Two doses of weekly oral MK2206 were administered at days - 9 and - 2 before surgery. The primary endpoint was reduction of pAktSer473 in breast tumor tissue from diagnostic biopsy to surgery. Secondary endpoints included changes in PI3K/AKT pathway tumor markers, tumor proliferation (ki-67), insulin growth factor pathway blood markers, pharmacokinetics (PK), genomics, and MK-2206 tolerability...
May 7, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29735310/factors-leading-to-the-discard-of-deceased-donor-kidneys-in-the-united-states
#15
Sumit Mohan, Mariana C Chiles, Rachel E Patzer, Stephen O Pastan, S Ali Husain, Dustin J Carpenter, Geoffrey K Dube, R John Crew, Lloyd E Ratner, David J Cohen
The proportion of deceased donor kidneys procured for transplant but subsequently discarded has been growing steadily in the United States, but factors contributing to the rising discard rate remain unclear. To assess the reasons for and probability of organ discard we assembled a cohort of 212,305 deceased donor kidneys recovered for transplant from 2000-2015 in the SRTR registry that included 36,700 kidneys that were discarded. 'Biopsy Findings' (38.2%) was the most commonly reported reason for discard. The median Kidney Donor Risk Index of discarded kidneys was significantly higher than transplanted organs (1...
May 5, 2018: Kidney International
https://www.readbyqxmd.com/read/29735225/articles-that-may-change-your-practice-right-patient-right-crew-right-destination
#16
REVIEW
Russell D MacDonald
No abstract text is available yet for this article.
May 2018: Air Medical Journal
https://www.readbyqxmd.com/read/29730774/in-flight-cardiac-arrest-and-in-flight-cardiopulmonary-resuscitation-during-commercial-air-travel-consensus-statement-and-supplementary-treatment-guideline-from-the-german-society-of-aerospace-medicine-dglrm
#17
Jochen Hinkelbein, Lennert Böhm, Stefan Braunecker, Harald V Genzwürker, Steffen Kalina, Fabrizio Cirillo, Matthieu Komorowski, Andreas Hohn, Jörg Siedenburg, Michael Bernhard, Ilse Janicke, Christoph Adler, Stefanie Jansen, Eckard Glaser, Pawel Krawczyk, Mirko Miesen, Janusz Andres, Edoardo De Robertis, Christopher Neuhaus
By the end of the year 2016, approximately 3 billion people worldwide travelled by commercial air transport. Between 1 out of 14,000 and 1 out of 50,000 passengers will experience acute medical problems/emergencies during a flight (i.e., in-flight medical emergency). Cardiac arrest accounts for 0.3% of all in-flight medical emergencies. So far, no specific guideline exists for the management and treatment of in-flight cardiac arrest (IFCA). A task force with clinical and investigational expertise in aviation, aviation medicine, and emergency medicine was created to develop a consensus based on scientific evidence and compiled a guideline for the management and treatment of in-flight cardiac arrests...
May 5, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29724177/effectiveness-of-informational-decision-aids-and-a-live-donor-financial-assistance-program-on-pursuit-of-live-kidney-transplants-in-african-american-hemodialysis-patients
#18
L Ebony Boulware, Patti L Ephraim, Jessica Ameling, LaPricia Lewis-Boyer, Hamid Rabb, Raquel C Greer, Deidra C Crews, Bernard G Jaar, Priscilla Auguste, Tanjala S Purnell, Julio A Lamprea-Monteleagre, Tope Olufade, Luis Gimenez, Courtney Cook, Tiffany Campbell, Ashley Woodall, Hema Ramamurthi, Cleomontina A Davenport, Kingshuk Roy Choudhury, Matthew R Weir, Donna S Hanes, Nae-Yuh Wang, Helene Vilme, Neil R Powe
BACKGROUND: African Americans have persistently poor access to living donor kidney transplants (LDKT). We conducted a small randomized trial to provide preliminary evidence of the effect of informational decision support and donor financial assistance interventions on African American hemodialysis patients' pursuit of LDKT. METHODS: Study participants were randomly assigned to receive (1) Usual Care; (2) the Providing Resources to Enhance African American Patients' Readiness to Make Decisions about Kidney Disease (PREPARED); or (3) PREPARED plus a living kidney donor financial assistance program...
May 3, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29722847/dietary-acid-load-and-bone-turnover-during-long-duration-spaceflight-and-bed-rest
#19
Sara R Zwart, Barbara L Rice, Holly Dlouhy, Linda C Shackelford, Martina Heer, Matthew D Koslovsky, Scott M Smith
Background: Bed rest studies document that a lower dietary acid load is associated with lower bone resorption. Objective: We tested the effect of dietary acid load on bone metabolism during spaceflight. Design: Controlled 4-d diets with a high or low animal protein-to-potassium (APro:K) ratio (High and Low diets, respectively) were given to 17 astronauts before and during spaceflight. Each astronaut had 1 High and 1 Low diet session before flight and 2 High and 2 Low sessions during flight, in addition to a 4-d session around flight day 30 (FD30), when crew members were to consume their typical in-flight intake...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29709187/integrating-dispersants-in-oil-spill-response-in-arctic-and-other-icy-environments
#20
Alun Lewis, Roger C Prince
Future oil exploration and marine navigation may well extend into the Arctic Ocean, and government agencies and responders need to plan for accidental oil spills. We argue that dispersants should play an important role in these plans, since they have substantial logistical benefits, work effectively under Arctic conditions, and stimulate the rapid biodegradation of spilled oil. They also minimize the risk of surface slicks to birds and mammals, the stranding of oil on fragile shorelines and minimize the need for large work crews to be exposed to Arctic conditions...
April 30, 2018: Environmental Science & Technology
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