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https://www.readbyqxmd.com/read/27925796/a-severe-asthma-disease-signature-from-gene-expression-profiling-of-peripheral-blood-from-u-biopred-cohorts
#1
Jeannette Bigler, Michael Boedigheimer, James P R Schofield, Paul J Skipp, Julie Corfield, Anthony Rowe, Ana R Sousa, Martin Timour, Lori Twehues, Xuguang Hu, Graham Roberts, Andrew A Welcher, Wen Yu, Kian F Chung, Ian M Adcock, Peter J Sterk, Ratko Djukanović
RATIONALE: Stratification of asthma at the molecular level, especially using accessible biospecimens, could greatly enable patient selection for targeted therapy. OBJECTIVES: To determine the value of blood to identify transcriptional differences between clinically defined asthmatic and non-asthmatic groups, identify potential patient subgroups based on gene expression, and explore biological pathways associated with identified differences. METHODS: Transcriptomics profiles were generated by microarray analysis of blood from 610 asthmatic and control participants in U-BIOPRED...
December 7, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27925151/development-of-a-clinical-diagnostic-matrix-for-characterising-inherited-epidermolysis-bullosa
#2
V K Yenamandra, C Moss, V Sreenivas, M Khan, S Sivasubbu, V K Sharma, G Sethuraman
BACKGROUND: Accurately diagnosing the subtype of Epidermolysis Bullosa (EB) is critical for management and genetic counseling. Modern laboratory techniques are largely inaccessible in developing countries, where the diagnosis remains clinical and often inaccurate. OBJECTIVE OF THE STUDY: To develop a simple clinical diagnostic tool to aid in the diagnosis and sub typing of EB. METHODS: We developed a matrix indicating presence or absence of a set of distinctive clinical features (rows) for the 9 more prevalent EB subtypes (columns)...
December 7, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27924996/n-heterocyclic-carbene-or-phosphorus-ylide-which-one-forms-a-stronger-bond-with-group-11-metals-a-theoretical-study
#3
Mehdi Bayat, Asieh Sedghi, Leila Ebrahimkhani, Seyyed Javad Sabounchei
N-Heterocyclic carbene and phosphorus ylides are inorganic and organometallic ligands, and their coordination chemistry with transition elements, particularly group 11 metals, would be noticeable. This study seeks to characterize the structure and nature of the C→M bond of group 11 metals (M = Cu(i), Ag(i), Au(i)) in coordination with different monodentate phosphorus ylides {P(Ph)3CHR} and N-heterocyclic carbenes (NHC(R)) (where R = F, Cl, Br, CF3, CH3, H, C(CH3)3, Si(CH3)3, SiH3, Ph). In this regard, DFT calculations with the PBE/def2-TZVP level of theory were applied...
December 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27923762/treatment-of-acute-perilunate-dislocations-orif-versus-proximal-row-carpectomy
#4
Thibaut Muller, Juan José Hidalgo Diaz, Emilie Pire, Guillaume Prunières, Sybille Facca, Philippe Liverneaux
PURPOSE: Some authors have proposed performing proximal row carpectomy (PRC) as the initial treatment for perilunate dislocations. HYPOTHESIS: The goal of this retrospective study was to compare the results of a cohort of perilunate dislocation cases that were operated by ORIF (open reduction and internal fixation) or by PRC between 2006 and 2011. METHODS: The cohort consisted of 21 men with a mean age of 33 years, who either had an isolated perilunate dislocation (7 cases) or a fracture-dislocation (14 cases)...
December 3, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27922841/stress-resiliency-practices-in-neonatal-nurses
#5
Lisa M Pannell, Lynn Rowe, Salena Tully
BACKGROUND: Multiple environmental changes were experienced in a large level III neonatal intensive care unit (NICU) causing a perception of work-related stress leading to high nurse turnover, decreased engagement, and decreased satisfaction. PURPOSE: To identify a preintervention measure of perceived stress resiliency and ranking of interpretive styles in a population of neonatal, bedside registered nurses faced with a change in the physical practice environment...
December 5, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27920847/liposarcoma-metastases-to-the-small-bowel-presenting-as-fat-density-intraluminal-lesions
#6
Steven P Rowe, Stephanie F Coquia, Pamela T Johnson, Elliot K Fishman
Metastatic disease to the small bowel is rare; however, it is important to recognize that when it does occurs a variety of complications are possible including obstruction, gastrointestinal bleeding, intussusception, and bowel perforation. We present here an unusual case of small bowel metastases in a patient with known metastatic liposarcoma in which the lesions manifested as rapidly evolving fat-density masses that necessitated segmental small bowel resection. Careful scrutiny of the small bowel in oncology patients is necessary to guide appropriate treatment and avoid potential catastrophic complications from small bowel metastases...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920488/evalmsa-a-program-to-evaluate-multiple-sequence-alignments-and-detect-outliers
#7
Alvaro Chiner-Oms, Fernando González-Candelas
We present EvalMSA, a software tool for evaluating and detecting outliers in multiple sequence alignments (MSAs). This tool allows the identification of divergent sequences in MSAs by scoring the contribution of each row in the alignment to its quality using a sum-of-pair-based method and additional analyses. Our main goal is to provide users with objective data in order to take informed decisions about the relevance and/or pertinence of including/retaining a particular sequence in an MSA. EvalMSA is written in standard Perl and also uses some routines from the statistical language R...
2016: Evolutionary Bioinformatics Online
https://www.readbyqxmd.com/read/27918597/seqplots-interactive-software-for-exploratory-data-analyses-pattern-discovery-and-visualization-in-genomics
#8
Przemyslaw Stempor, Julie Ahringer
Experiments involving high-throughput sequencing are widely used for analyses of chromatin function and gene expression. Common examples are the use of chromatin immunoprecipitation for the analysis of chromatin modifications or factor binding, enzymatic digestions for chromatin structure assays, and RNA sequencing to assess gene expression changes after biological perturbations. To investigate the pattern and abundance of coverage signals across regions of interest, data are often visualized as profile plots of average signal or stacked rows of signal in the form of heatmaps...
2016: Wellcome Open Res
https://www.readbyqxmd.com/read/27918297/a-novel-one-dimensional-double-chain-like-zn-ii-coordination-polymer-poly-bis-1-benzyl-1h-imidazole-%C3%AE%C2%BAn-3-tris-%C3%AE-cyanido-%C3%AE%C2%BA-2-c-n-cyanido-%C3%AE%C2%BAc-disilver-i-zinc-ii
#9
Pattiya Krinchampa, Kittipong Chainok, Siriporn Phengthaisong, Sujittra Youngme, Filip Kielar, Nanthawat Wannarit
One of most interesting systems of coordination polymers constructed from the first-row transition metals is the porous Zn(II) coordination polymer system, but the numbers of such polymers containing N-donor linkers are still limited. The title double-chain-like Zn(II) coordination polymer, [Ag2Zn(CN)4(C10H10N2)2]n, presents a one-dimensional linear coordination polymer structure in which Zn(II) ions are linked by bridging anionic dicyanidoargentate(I) units along the crystallographic b axis and each Zn(II) ion is additionally coordinated by a terminal dicyanidoargentate(I) unit and two terminal 1-benzyl-1H-imidazole (BZI) ligands, giving a five-coordinated Zn(II) ion...
December 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27917588/the-effect-of-liver-transplantation-on-the-quality-of-life-of-the-recipient-s-main-caregiver-a-systematic-review
#10
REVIEW
Alastair L Young, Ian A Rowe, Kate Absolom, Rebecca L Jones, Amy Downing, Nick Meader, Adam Glaser, Giles J Toogood
INTRODUCTION: Liver transplantation (LT) is a transformative, life-saving procedure with life-long sequale for patients and their caregivers. The impact of LT on the patient's main caregiver can be underestimated. We carried out a systematic review of the impact of LT on the Health Related Quality of Life (HRQL) of LT patients' main caregivers. METHODS: We searched 13 medical databases from 1996 to 2015. We included studies with HRQL data on caregivers of patients following LT then quality assessed and narratively synthesized the findings from these studies...
December 5, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27917046/a-new-species-of-pentamera-ayres-1852-from-the-brazilian-coast-holothuroidea-dendrochirotida-phyllophoridae
#11
Jéssica Prata, Martin L Christoffersen
Pentamera paraibanensissp. n. is described from more than 3000 specimens as a new species of Phyllophoridae from northeast Brazil, in the tropical southwestern Atlantic. It is distinguished from its congeners by the shape of the calcareous ring with moderate posterior processes, and by the tables in the body wall with a usually quadrilocular disc and a low, toothed spire composed of two pillars. The body is brown, with the tube feet in double rows per ambulacrum, and tentacles more lightly colored. The species was found inside rodoliths in large numbers...
2016: ZooKeys
https://www.readbyqxmd.com/read/27914650/towards-upright-pedalling-to-drive-recovery-in-people-who-cannot-walk-in-the-first-weeks-after-stroke-movement-patterns-and-measurement
#12
Nicola J Hancock, Lee Shepstone, Philip Rowe, Phyo K Myint, Valerie M Pomeroy
OBJECTIVES: To examine whether people who are within 31days of stroke onset are able to produce controlled lower limb movement, and phasic activity in antagonistic lower limb muscle groups, during Upright Pedalling (UP). DESIGN: Observational study. SETTING: Acute stroke unit within a University Hospital. PARTICIPANTS: Eight adults between 3 and 30days from stroke onset, with unilateral lower limb paresis and unable to walk without assistance...
November 15, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27914499/exercise-training-improves-exercise-capacity-and-quality-of-life-after-transcatheter-aortic-valve-implantation-a-randomized-pilot-trial
#13
Axel Pressler, Jeffrey W Christle, Benjamin Lechner, Viola Grabs, Bernhard Haller, Ina Hettich, David Jochheim, Julinda Mehilli, Rüdiger Lange, Sabine Bleiziffer, Martin Halle
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is increasingly applied for aortic stenosis in elderly patients with impaired mobility and reduced quality of life. These patients may particularly benefit from postinterventional exercise programs, but no randomized study has evaluated the safety and efficacy of exercise in this population. METHODS: In a prospective pilot study, 30 patients after TAVI (mean age, 81±6 years, 44% female, 83±34 days postintervention) were randomly allocated 1:1 to a training group (TG) performing 8 weeks of supervised combined endurance and resistance exercise or to usual care...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27914115/molecular-phylogeny-and-taxonomy-of-a-new-freshwater-hymenostomatid-from-northeastern-china-with-the-establishment-of-a-new-genus-anteglaucoma-gen-n-protista-ciliophora-oligohymenophorea
#14
Xuming Pan, Zihan Shi, Chundi Wang, William A Bourland, Ying Chen, Weibo Song
The morphology, infraciliature and SSU rDNA sequence of a new freshwater hymenostomatid ciliate, Anteglaucoma harbinensis gen. nov., spec. nov., collected from a farmland pond in Harbin, China, were investigated. The new genus Anteglaucoma is characterized as follows: small to medium-sized Glaucomidae with oral apparatus in anterior one-third of cell; paroral membrane composed of almost longitudinally arranged dikinetids; three adoral membranelles nearly equal in length and arranged almost longitudinally in parallel; silverline pattern tetrahymenid...
November 7, 2016: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/27913603/the-tumor-suppressor-flcn-mediates-an-alternate-mtor-pathway-to-regulate-browning-of-adipose-tissue
#15
Shogo Wada, Michael Neinast, Cholsoon Jang, Yasir H Ibrahim, Gina Lee, Apoorva Babu, Jian Li, Atsushi Hoshino, Glenn C Rowe, James Rhee, José A Martina, Rosa Puertollano, John Blenis, Michael Morley, Joseph A Baur, Patrick Seale, Zoltan Arany
Noncanonical mechanistic target of rapamycin (mTOR) pathways remain poorly understood. Mutations in the tumor suppressor folliculin (FLCN) cause Birt-Hogg-Dubé syndrome, a hamartomatous disease marked by mitochondria-rich kidney tumors. FLCN functionally interacts with mTOR and is expressed in most tissues, but its role in fat has not been explored. We show here that FLCN regulates adipose tissue browning via mTOR and the transcription factor TFE3. Adipose-specific deletion of FLCN relieves mTOR-dependent cytoplasmic retention of TFE3, leading to direct induction of the PGC-1 transcriptional coactivators, drivers of mitochondrial biogenesis and the browning program...
December 2, 2016: Genes & Development
https://www.readbyqxmd.com/read/27911950/a-specialized-multi-transmit-head-coil-for-high-resolution-fmri-of-the-human-visual-cortex-at-7t
#16
Shubharthi Sengupta, Alard Roebroeck, Valentin G Kemper, Benedikt A Poser, Jan Zimmermann, Rainer Goebel, Gregor Adriany
PURPOSE: To design, construct and validate radiofrequency (RF) transmit and receive phased array coils for high-resolution visual cortex imaging at 7 Tesla. METHODS: A 4 channel transmit and 16 channel receive array was constructed on a conformal polycarbonate former. Transmit field efficiency and homogeneity were simulated and validated, along with the Specific Absorption Rate, using [Formula: see text] mapping techniques and electromagnetic simulations. Receiver signal-to-noise ratio (SNR), temporal SNR (tSNR) across EPI time series, g-factors for accelerated imaging and noise correlations were evaluated and compared with a commercial 32 channel whole head coil...
2016: PloS One
https://www.readbyqxmd.com/read/27910832/vacancy-pairing-and-superstructure-in-the-high-pressure-silicate-k1-5mg2si2o7h0-5-a-new-potential-host-for-potassium-in-the-deep-earth
#17
M D Welch, L Bindi, V Petříček, J Plášil
The high-pressure silicate K1.5Mg2Si2O7H0.5, synthesized and characterized by Welch et al. [(2012), Am. Mineral. 97, 1849-1857], has been re-examined with the aim of determining the nature of the superstructure noted in their study. The composition corresponds to a 1:1 combination of KMg2Si2O7H and K2Mg2Si2O7 end-members, but it is not a solid solution. Single-crystal X-ray diffraction data for one of the original K1.5Mg2Si2O7H0.5 crystals synthesized at 16 GPa/1573 K, has been collected using a much longer exposure time in order to improve the intensity statistics of weak superlattice reflections identified by Welch et al...
December 1, 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/27910523/first-measurement-of-the-edge-charge-exchange-recombination-spectroscopy-on-east-tokamak
#18
Y Y Li, X H Yin, J Fu, D Jiang, S Y Feng, B Lyu, Y J Shi, Y Yi, X J Zhou, C D Hu, M Y Ye, B N Wan
An edge toroidal charge exchange recombination spectroscopy (eCXRS) diagnostic, based on a heating neutral beam injection (NBI), has been deployed recently on the Experimental Advanced Superconducting Tokamak (EAST). The eCXRS, which aims to measure the plasma ion temperature and toroidal rotation velocity in the edge region simultaneously, is a complement to the exiting core CXRS (cCXRS). Two rows with 32 fiber channels each cover a radial range from ∼2.15 m to ∼2.32 m with a high spatial resolution of ∼5-7 mm...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910357/diagnostics-for-molybdenum-and-tungsten-erosion-and-transport-in-nstx-u
#19
F Scotti, V A Soukhanovskii, M E Weller
A comprehensive set of spectroscopic diagnostics is planned in the National Spherical Torus Experiment Upgrade to connect measurements of molybdenum and tungsten divertor sources to scrape-off layer (SOL) and core impurity transport, supporting the installation of high-Z plasma facing components which is scheduled to begin with a row of molybdenum tiles. Imaging with narrow-bandpass interference filters and high-resolution spectroscopy will be coupled to estimate divertor impurity influxes. Vacuum ultraviolet and extreme ultraviolet spectrometers will allow connecting high-Z sources to SOL transport and core impurity content...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909668/triple-row-modification-of-the-suture-bridge-technique-for-arthroscopic-rotator-cuff-repair
#20
Roger V Ostrander, Jarrod Smith, Michael Saper
Recent advances to improve outcomes in rotator cuff repair include using arthroscopic double-row suture-bridge techniques in an effort to reconstruct the rotator cuff footprint and improve fixation. However, when using this technique for larger tears, it can be difficult to get the lateral portion of the rotator cuff into an anatomic position. This report describes a triple-row modification of the suture-bridge technique that results in significantly more footprint contact area and contact pressure compared with the double-row and standard suture-bridge techniques...
October 2016: Arthroscopy Techniques
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