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https://www.readbyqxmd.com/read/29329963/switch-to-ticagrelor-in-critical-limb-ischemia-antiplatelet-study-stt-clips
#1
Leonardo C Clavijo, Ashwat Dhillon, Noor Al-Asady, Ray V Matthews, Jorge Caro, Han Tun, Vincent Rowe, David M Shavelle
OBJECTIVE: To investigate platelet reactivity in patients with critical limb ischemia (CLI) after switching from clopidogrel to ticagrelor. BACKGROUND: High on-treatment platelet reactivity (HPR) is highly prevalent in patients with CLI treated with clopidogrel. The effect of ticagrelor in patients with CLI is not known, however. METHODS: We performed P2Y12 platelet receptor inhibition studies (VASP and VerifyNow) in 50 patients with CLI. Tests were performed before and 6±1h after daily 75mg clopidogrel dose...
September 5, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29329886/solid-phase-extraction-of-chlorophenols-in-seawater-using-a-magnetic-ionic-liquid-molecularly-imprinted-polymer-with-incorporated-silicon-dioxide-as-a-sorbent
#2
Wanwan Ma, Kyung Ho Row
A type of magnetic ionic liquid based molecularly imprinted polymer coated on SiO2 (Fe3O4@SiO2@IL-MIPs) was prepared with 1-vinyl-3-ethylimidazole ionic liquid as functional monomer, and 1,4-butane-3,3'-bis-1-ethylimidazole ionic liquid as cross linker, 4-Chlorophenol as template was successfully applied as a selective adsorbent for selective extraction of 5 chlorophenols in seawater samples by using the magnetic solid-phase extraction (MSPE) method. 11 types of Fe3O4@SiO2@IL-MIPs were synthesized and investigated for their different compositions of functional monomer (such as [C2min][Br], [C2min][BF4], [C2min][PF6], acrylamide, methacrylic acid and 4-vinyl pyridine) and cross-linker (such as [C4min2][Br], [C4min2][BF4], [C4min2][PF6], divinylbenzene, and ethylene glycol dimethacrylate), respectively...
January 6, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29329425/comparison-of-hepatic-2d-sandwich-cultures-and-3d-spheroids-for-long-term-toxicity-applications-a-multi-center-study
#3
Catherine C Bell, Anita C A Dankers, Volker M Lauschke, Rowena Sison-Young, Roz Jenkins, Cliff Rowe, Chris Goldring, Kevin Park, Sophie Regan, Tracy Walker, Chris Schofield, Audrey Baze, Alison J Foster, Dominic Williams, Amy W M van de Ven, Frank Jacobs, Jos van Houdt, Tuula Lähteenmäki, Jan Snoeys, Satu Juhila, Lysiane Richert, Magnus Ingelman-Sundberg
Primary human hepatocytes (PHH) are commonly used for in vitro studies of drug-induced liver injury. However, when cultured as 2D monolayers, PHH lose crucial hepatic functions within hours. This dedifferentiation can be ameliorated when PHH are cultured in sandwich configuration (2Dsw), particularly when cultures are regularly re-overlaid with extracellular matrix, or as 3D spheroids. In this study, the six participating laboratories evaluated the robustness of these two model systems made from cryopreserved PHH from the same donors considering both inter-donor and inter-lab variability and compared their suitability for use in repeated-dose toxicity studies using 5 different hepatotoxins with different toxicity mechanisms...
January 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29329059/amyloid-burden-and-incident-depressive-symptoms-in-preclinical-alzheimer-s-disease
#4
Stephanie Perin, Karra D Harrington, Yen Ying Lim, Kathryn Ellis, David Ames, Robert H Pietrzak, Adrian Schembri, Stephanie Rainey-Smith, Olivier Salvado, Simon M Laws, Ralph N Martins, Victor L Villemagne, Christopher C Rowe, Colin L Masters, Paul Maruff
BACKGROUND: Relationships between depression and Alzheimer's disease (AD) may become clearer if studied in preclinical AD where dementia is not present. METHOD: The aim of this study was to evaluate prospectively, relationships between brain amyloid-β (Aβ), depressive symptoms and screen positive depression in cognitively normal (CN) older adults. Depressive symptoms were measured with the Geriatric Depression Inventory (GDS-15) in CN adults from the Australian Imaging Biomarkers and Lifestyle (AIBL) study without depression at baseline and classified as having abnormally high (Aβ+; n = 136) or low (Aβ-; n = 449) Aβ according to positron emission tomography at 18-month intervals over 72 months...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29328256/nanoscale-beam-splitters-based-on-gradient-metasurfaces
#5
Di Zhang, Mengxin Ren, Wei Wu, Ninghui Gao, Xuanyi Yu, Wei Cai, Xinzheng Zhang, Jingjun Xu
Beam splitters are essential components in various optical and photonic applications, for example, interferometers, multiplexers, and so on. Present beam splitters based on cubes or plates are normally bulky. Realizing beam splitters in nanoscales is useful to reduce the total size of photonic devices. We demonstrate here a beam splitter with nanoscale thickness based on a gradient metasurface comprising lithium niobate cylinder arrays. Since one unit cell of metasurface comprising two cylinder rows shows two opposite phase gradients, the incident light is split into different directions according to the generalized Snell's law...
January 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29327106/mdct-of-ductus-diverticulum-3d-cinematic-rendering-to-enhance-understanding-of-anatomic-configuration-and-avoid-misinterpretation-as-traumatic-aortic-injury
#6
Steven P Rowe, Pamela T Johnson, Elliot K Fishman
Acute aortic injuries are not common in the setting of severe blunt trauma, but lead to significant morbidity and mortality. High-quality MDCT with 2D MPRs and 3D rendering are essential to identify aortic trauma and distinguish anatomic variants and other forms of aortic pathology from an acute injury. Misinterpretation of mimics of acute aortic injury can lead to unnecessary arteriography and thoracic surgery. Since most traumatic injuries occur in the distal arch, radiologists must be cognizant of the range of appearances of variants related to the ductus diverticulum...
January 11, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29327070/-open-repair-of-gluteus-medius-and-minimus-tendons-tears-with-double-row-technique-clinical-and-radiological-results
#7
J H Schröder, M Geßlein, M Schütz, C Perka, D Krüger
BACKGROUND: Operative refixation is a new therapeutic option in cases of failed conservative treatment for trochanteric pain syndrome (TPS) and lesions of the hip abductors in magnetic resonance imaging (MRI). OBJECTIVE: Evaluation of the clinical and radiological results after open gluteus medius and minimus tendon reconstruction with a double-row technique was carried out. MATERIAL AND METHODS: Patients with failed conservative treatment for TPS and confirmed lesions of the hip abductors in MRI were treated by open hip abductor tendon reconstruction with a double-row technique...
January 11, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29326203/high-quality-whole-genome-sequences-for-21-enterotoxigenic-escherichia-coli-strains-generated-with-pacbio-sequencing
#8
Peyton Smith, Rebecca L Lindsey, Lori A Rowe, Dhwani Batra, Devon Stripling, Lisley Garcia-Toledo, Daniel Drapeau, Kristen Knipe, Nancy Strockbine
Enterotoxigenic Escherichia coli (ETEC) is an important diarrheagenic pathogen. We report here the high-quality whole-genome sequences of 21 ETEC strains isolated from patients in the United States, international diarrheal surveillance studies, and cruise ship outbreaks.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29324476/revisiting-autologous-transplantation-in-acute-myeloid-leukemia
#9
Chezi Ganzel, Jacob M Rowe
PURPOSE OF REVIEW: Autologous hematopoietic cell transplantation (auto-HCT) has been evaluated as a consolidation treatment for acute myeloid leukemia (AML) in the 1980s and 1990s. These prospective studies from large trials compared auto-HCT with chemotherapy. A comparison was made also with allogeneic hematopoietic cell transplantation (allo-HCT). These studies reported a lower relapse rate with auto-HCT compared with chemotherapy, but without impact on the overall survival. A high transplant-related mortality in that era confounded the relevance of these data...
January 10, 2018: Current Opinion in Hematology
https://www.readbyqxmd.com/read/29324078/what-an-evidence-based-guideline-for-fatigue-risk-management-means-for-us-statements-from-stakeholders
#10
J Brent Myers, R Keith Wages, Dennis Rowe, Chris Nollette, Michael Touchstone, John Sinclair, Edward L Mund, Justin M Eberly, John D Montes, Richard J Sherlock, Laura K Barger, Sean P A Drummond, Indira Gurubhagavatula
No abstract text is available yet for this article.
January 11, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29323925/the-responsiveness-of-patient-reported-outcome-tools-in-shoulder-surgery-is-dependent-on-the-underlying-pathological-condition
#11
R Zackary Unger, Jeremy M Burnham, Lee Gammon, Chaitu S Malempati, Cale A Jacobs, Eric C Makhni
BACKGROUND: Given the high number of available patient-reported outcome (PRO) tools for patients undergoing shoulder surgery, comparative information is necessary to determine the most relevant forms to incorporate into clinical practice. PURPOSE: To determine the utilization and responsiveness of common PRO tools in studies involving patients undergoing arthroscopic rotator cuff repair or operative management of glenohumeral instability. STUDY DESIGN: Systematic review...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29323675/a-systematic-examination-of-classical-and-multi-center-bonding-in-heteroborane-clusters
#12
Petr Melichar, Drahomír Hnyk, Jindřich Fanfrlík
This paper presents a systematic study of multicenter and classical bonding on a broad series of experimentally known heteroboranes covering closo, nido, arachno and hypho types of cages with incorporated tetrel, pnictogen or chalcogen heterovertices up to the third-row elements. The nature of bonding is studied using a novel quantum-chemical tool, the intrinsic atomic/bond orbital (IAO/IBO) approach, which provides a direct connection between quantum chemistry and chemical concepts. We also discuss how the computed IBO properties are related to molecular observables such as interatomic distances, molecular electrostatic potential surfaces and dipole moments...
January 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29323416/citizenship-and-community-mental-health-care
#13
Allison N Ponce, Michael Rowe
Citizenship is an approach to supporting the social inclusion and participation in society of people with mental illnesses. It is receiving greater attention in community mental health discourse and literature in parallel with increased awareness of social determinants of health and concern over the continued marginalization of persons with mental illness in the United States. In this article, we review the definition and principles of our citizenship framework with attention to social participation and access to resources as well as rights and responsibilities that society confers on its members...
January 11, 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29322403/divorce-separation-and-housing-changes-a-multiprocess-analysis-of-longitudinal-data-from-england-and-wales
#14
Júlia Mikolai, Hill Kulu
This study investigates the effect of marital and nonmarital separation on individuals' residential and housing trajectories. Using rich data from the British Household Panel Survey (BHPS) and applying multilevel competing-risks event history models, we analyze the risk of a move of single, married, cohabiting, and separated men and women to different housing types. We distinguish moves due to separation from moves of separated people and account for unobserved codeterminants of moving and separation risks...
January 10, 2018: Demography
https://www.readbyqxmd.com/read/29322320/is-there-a-relationship-between-the-load-distribution-on-the-tibial-plateau-and-hip-knee-ankle-angle-after-tka
#15
Takao Kaneko, Norihiko Kono, Yuta Mochizuki, Hiroyasu Ikegami, Yoshiro Musha
INTRODUCTION: This study asked whether differences in coronal alignment after total knee arthroplasty (TKA) affect the load distribution on the tibial plateau. The aim of this study was to investigate the correlation between coronal alignment and the load distribution on the tibial plateau after TKA, using three-dimensional multi-detector-row-computed tomography (3D-MDCT). MATERIALS AND METHODS: In this study, we performed 84 cementless TKA with porous tantalum modular tibial component (PTMT) and divided into three groups based on post-operative hip-knee-ankle (HKA) angle: varus alignment group (n = 22), (176° ≧) neutral alignment group (n = 45), (180° ± 3°), and valgus alignment group (n = 17) (184° ≦)...
January 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29322298/a-new-microsporidium-fibrillaspora-daphniae-g-n-sp-n-infecting-daphnia-magna-crustacea-cladocera-in-siberia-and-its-taxonomic-placing-within-a-new-family-fibrillasporidae-and-new-superfamily-tubulinosematoidea-opisthosporidia-microsporidia
#16
Anastasia V Simakova, Yuri S Tokarev, Irma V Issi
Infection with a new microsporidium, Fibrillaspora daphniae g. n. sp. n., was found in a local Daphnia magna population in Tomsk region (Western Siberia, Russia) at the prevalence rate of 52%. Histological sections showed parasite cells entirely encompassing the host haemocoel. Methanol-fixed spores were elongate, oval, 4.8 ± 0.3 μm × 2.3 ± 0.2 μm in size. All developmental stages were in direct contact with the host cell cytoplasm, with single nuclei, and division by binary fission. The sporont surface was covered with an additional outer layer composed of fine tubules...
January 10, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29322147/self-assembly-of-1-3-5-benzenetribenzoic-acid-on-ag-and-cu-at-the-liquid-solid-interface
#17
Hannah Aitchison, Hao Lu, Rodrigo Ortiz de la Morena, Izabela Cebula, Michael Zharnikov, Manfred Buck
Assembly of 1,3,5-benzenetribenzoic acid (H3BTB) from solution on Au substrates modified by underpotential deposited Ag and Cu layers was studied by near edge X-ray absorption fine structure spectroscopy, X-ray photoelectron spectroscopy and scanning tunneling microscopy. Adsorption of H3BTB on Cu resulted in disordered layers with sporadic occurrence of ordered molecular aggregates. In contrast, highly ordered layers were obtained on Ag which exhibit a pronounced row structure and involve a monopodal bidentate adsorption geometry of the molecules through carboxylate coordinating bonding...
January 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29321389/aortic-root-calcification-score-as-an-independent-factor-for-predicting-major-adverse-cardiac-events-in-familial-hypercholesterolemia
#18
Hirofumi Okada, Hayato Tada, Kenshi Hayashi, Hiroki Kawashima, Tadanori Takata, Kenji Sakata, Atsushi Nohara, Hiroshi Mabuchi, Masakazu Yamagishi, Masa-Aki Kawashiri
AIM: The aims of this study were: 1) to determine whether the accumulation of aortic root calcification (ARC) assessed using coronary computed tomography angiography (CCTA) can predict future cardiovascular events, and 2) to estimate the onset and progression of ARC in patients with familial hypercholesterolemia (FH). METHODS: One hundred thirteen consecutive Japanese patients with heterozygous FH (male=54, mean age=52.1±15.6 years, mean LDL-C=299.0±94.6 mg/dL), without known coronary artery disease, who underwent 64-detector row CCTA were retrospectively evaluated...
January 10, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29321377/development-of-an-airway-mucus-defect-in-the-cystic-fibrosis-rat
#19
Susan E Birket, Joy M Davis, Courtney M Fernandez, Katherine L Tuggle, Ashley M Oden, Kengyeh K Chu, Guillermo J Tearney, Michelle V Fanucchi, Eric J Sorscher, Steven M Rowe
The mechanisms underlying the development and natural progression of the airway mucus defect in cystic fibrosis (CF) remain largely unclear. New animal models of CF, coupled with imaging using micro-optical coherence tomography, can lead to insights regarding these questions. The Cftr-/- (KO) rat allows for longitudinal examination of the development and progression of airway mucus abnormalities. The KO rat exhibits decreased periciliary depth, hyperacidic pH, and increased mucus solid content percentage; however, the transport rates and viscoelastic properties of the mucus are unaffected until the KO rat ages...
January 11, 2018: JCI Insight
https://www.readbyqxmd.com/read/29320551/are-oral-deformities-in-tadpoles-accurate-indicators-of-anuran-chytridiomycosis
#20
Alba Navarro-Lozano, David Sánchez-Domene, Denise C Rossa-Feres, Jaime Bosch, Ricardo J Sawaya
We evaluated the use of oral deformities as reliable proxies for determining Batrachochytrium dendrobatidis (Bd) infection in tadpoles of six anuran species of the Atlantic Forest in southeastern Brazil. We examined oral discs of 2156 tadpoles of six species of anurans collected in 2016: Aplastodiscus albosignatus, Boana albopunctata, Boana faber, Scinax hayii, Crossodactylus caramaschii, and Physalaemus cuvieri. Three oral deformities were recognized: lack of keratinization only in upper and/or lower jaw sheaths, lack of keratinization only in upper or lower tooth rows, and both deformities together...
2018: PloS One
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