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https://www.readbyqxmd.com/read/28742878/assessment-of-the-effect-of-enteromorpha-prolifera-on-bacterial-community-structures-in-aquaculture-environment
#1
Guorong Lin, Fulin Sun, Chunzhong Wang, Li Zhang, Xinzhong Zhang
In recent years, Enteromorpha prolifera blooms had serious impacts on costal environments and fisheries in China. Nevertheless, the effects of E. prolifera on microbial ecology remain unknown. In this study, for the first time, an Illumina sequencing analysis was used to investigate bacterial communities in source water, aquaculture ponds with E. prolifera, and an aquaculture pond in which E. prolifera -free. Principal coordinate and phylogenic analyses revealed obvious differences among the bacterial communities in the pond water with and without E...
2017: PloS One
https://www.readbyqxmd.com/read/28741602/journal-of-radiological-protection-now-offers-reviewer-recognition-with-publons
#2
Maggie Simmons
Reviewers for Journal of Radiological Protection (JRP) are now able to track, verify and showcase their peer review contributions. IOP Publishing has partnered with Publons, a free service that enables reviewers to seamlessly have their reviewer records updated in Publons with the click of a button. As of 2017, reviewers for JRP will get the option to have a verified record of each review they do added to their Publons profile. Recognition will be given even if the reviews are anonymous and the manuscript is never published...
July 25, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28741334/endovascular-treatment-of-chronic-occluded-popliteal-artery-aneurysm-early-and-mid-term-outcomes
#3
Vincenzo Ardita, Alessia Giaquinta, Matteo Orrico, Sonia Ronchey, Massimiliano Veroux, Nicola Mangialardi, Pierfrancesco Veroux
BACKGROUND: Critical limb ischemia (CLI) may be the consequence of chronic occluded popliteal artery aneurysm (PAA). Open repair (OR) offers better 5-year results than endovascular treatment, but in patients with severe comorbidities or unfit to OR, endovascular repair (ER) could represent a valid treatment option. The purpose of this retrospective study was to review our experience of endovascular popliteal aneurism repair (EVPAR) in patients with chronic occluded PAA. METHODS: The endpoints assessed were: 1- and 3-year primary and secondary patency rates, technical success, 30-day major adverse events, major amputation free-survival, re-intervention and survival rates...
July 24, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28740850/the-role-of-dog-population-management-in-rabies-elimination-a-review-of-current-approaches-and-future-opportunities
#4
REVIEW
Louise H Taylor, Ryan M Wallace, Deepashree Balaram, Joann M Lindenmayer, Douglas C Eckery, Beryl Mutonono-Watkiss, Ellie Parravani, Louis H Nel
Free-roaming dogs and rabies transmission are integrally linked across many low-income countries, and large unmanaged dog populations can be daunting to rabies control program planners. Dog population management (DPM) is a multifaceted concept that aims to improve the health and well-being of free-roaming dogs, reduce problems they may cause, and may also aim to reduce dog population size. In theory, DPM can facilitate more effective rabies control. Community engagement focused on promoting responsible dog ownership and better veterinary care could improve the health of individual animals and dog vaccination coverage, thus reducing rabies transmission...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28740437/the-larynx-ruler-to-measure-height-and-profile-of-vocal-folds-a-proof-of-concept
#5
Gauthier Desuter, Benjamin Mertens, Alain Delchambre, Julie van Lith-Bijl, Peter Paul van Benthem, Elisabeth Sjögren
INTRODUCTION: Glottic leakage during phonation is a direct consequence of unilateral vocal fold (VF) paralysis. This air leakage can be in the horizontal plane and in the vertical plane. Presently, there is no easily applicable medical device allowing noninvasive, office-based measurement of the relative vertical position of the VFs. The larynx ruler (LR) is a laser-based measuring device that could meet the previously stated need, using a flexible endoscope. This study represents a proof of concept regarding the use of the LR in assessing VF relative positions in the vertical plane...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28739699/clinical-significance-and-phenotype-of-mta1-expression-in-esophageal-squamous-cell-carcinoma
#6
Hiroaki Honjo, Yasushi Toh, Makoto Sohda, Shigemasa Suzuki, Kyoichi Kaira, Yoshikatsu Kanai, Shushi Nagamori, Tetsunari Oyama, Takehiko Yokobori, Tatsuya Miyazaki, Hiroyuki Kuwano
BACKGROUND/AIM: Metastasis-associated gene 1 (MTA1) is considered a potential prognostic factor in esophageal cancer. We investigated the clinical relationship between MTA1, LAT1, and tumor metabolism, as evaluated by positron emission tomography (PET) in esophageal squamous cell carcinoma. MATERIALS AND METHODS: We analyzed 142 esophageal squamous cell carcinoma patients who underwent curative resection without preoperative treatment. MTA1 expression was assessed by immuno-zahistochemistry, and tested against standardized uptake values from preoperative PET-CT...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738577/high-bright-fluorescent-carbon-dot-as-versatile-sensing-platform
#7
Mumei Han, Liping Wang, Siheng Li, Liang Bai, Yunjie Zhou, Yue Sun, Hui Huang, Hao Li, Yang Liu, Zhenhui Kang
The surface functionalization will introduce additional functional groups on carbon dots (CDs) surface and then enrich the properties of CDs. Here, we show the various surface functionalized CDs (-COOH, -OH, -SH, -NH2, etc, named as NS-CDs) were synthesized with fascinating features, including high quantum efficiency (38.9%), long-term stability and good biocompatibility. Notably, it can serve as multifunction fluorescent probe in sensing system, including label-free detections in hydrogen peroxide (H2O2) with a wide linear range (1...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737706/redox-properties-of-tryptophan-metabolism-and-the-concept-of-tryptophan-use-in-pregnancy
#8
REVIEW
Kang Xu, Hongnan Liu, Miaomiao Bai, Jing Gao, Xin Wu, Yulong Yin
During pregnancy, tryptophan (Trp) is required for several purposes, and Trp metabolism varies over time in the mother and fetus. Increased oxidative stress (OS) with high metabolic, energy and oxygen demands during normal pregnancy or in pregnancy-associated disorders has been reported. Taking the antioxidant properties of Trp and its metabolites into consideration, we made four hypotheses. First, the use of Trp and its metabolites is optional based on their antioxidant properties during pregnancy. Second, dynamic Trp metabolism is an accommodation mechanism in response to OS...
July 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28737470/recent-advances-in-circulating-tumor-cells-and-cell-free-dna-in-metastatic-prostate-cancer-a-review
#9
Sunil Parimi, Jenny J Ko
The treatment landscape of metastatic prostate cancer has changed dramatically over the past five years. As new discoveries are made and further novel therapies become available, there is a heightened urgency to develop biomarkers that can guide prognoses and predict therapy responses. Circulating tumor cells (CTCs) and cell-free circulating tumor DNA (ctDNA) in the blood have emerged as potential promising tumor avatars. Areas covered: In this review, we describe technological breakthroughs and clinical implementation of the CTCs and ctDNA...
July 24, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28737374/an-integrated-sers-based-microdroplet-platform-for-the-automated-immunoassay-of-f1-antigens-in-yersinia-pestis
#10
Namhyun Choi, Jiyoung Lee, Juhui Ko, Jun Ho Jeon, Gi-Eun Rhie, Andrew J deMello, Jaebum Choo
The development of surface-enhanced Raman scattering (SERS)-based microfluidic platforms has attracted significant recent attention in the biological sciences. SERS is a highly sensitive detection modality, with microfluidic platforms providing many advantages over microscale methods, including high analytical throughput, facile automation and reduced sample requirements. Accordingly, the integration of SERS with microfluidic platforms offers significant utility in chemical and biological experimentation. Herein, we report a fully integrated SERS-based microdroplet platform for the automatic immunoassay of specific antigen fraction 1 (F1) in Yersinia pestis...
July 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28736911/observational-study-of-adherence-to-a-traditional-mediterranean-diet-sociocultural-characteristics-and-cardiovascular-disease-risk-factors-of-older-greek-australians-from-mediterranean-islands-medis-australia-study-protocol-and-rationale
#11
Antonia Thodis, Catherine Itsiopoulos, Antigone Kouris-Blazos, Laima Brazionis, Stefanos Tyrovolas, Evangelos Polychronopoulos, Demosthenes B Panagiotakos
AIM: To describe the study protocol of the MEDiterranean ISlands-Australia (MEDIS-Australia) Study modelled on the MEDIS Study conducted in Greece. The present study aims to explore adherence to the traditional Mediterranean diet pattern, determine enablers and barriers to adherence, explore the definition of Greek cuisine, and associations between adherence to the diet pattern and risk factors for cardiovascular disease (CVD) and metabolic syndrome in older Greek Australians originally from Greek islands and Cyprus...
July 24, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28736809/dose-evaluation-of-grid-therapy-using-a-6-mv-flattening-filter-free-fff-photon-beam-a-monte-carlo-study
#12
Immaculada Martínez-Rovira, Josep Puxeu, Yolanda Prezado
PURPOSE: Spatially fractionated radiotherapy is a strategy to overcome the main limitation of radiotherapy, i.e., the restrained normal tissue tolerances. A well-known example is Grid Therapy, which is currently performed at some hospitals using megavoltage photon beams delivered by Linacs. Grid Therapy has been successfully used in the management of bulky abdominal tumors with low toxicity. The aim of this work is to evaluate whether an improvement in therapeutic index in Grid Therapy can be obtained by implementing it in a flattening filter-free (FFF) Linac...
July 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28736786/an-enzyme-free-flow-cytometric-bead-assay-for-the-sensitive-detection-of-micrornas-based-on-click-nucleic-acid-ligation-mediated-signal-amplification
#13
Yan Qi, Liying Qiu, Wenjiao Fan, Chenghui Liu, Zhengping Li
A versatile flow cytometric bead assay (FCBA) coupled with a completely enzyme-free signal amplification mechanism is developed for the sensitive detection of microRNAs (miRNAs). This new strategy integrates click chemistry-mediated ligation chain reaction (CLCR) with hybridization chain reaction (HCR) for enzyme-free signal amplification on magnetic beads (MBs), and a flow cytometer for the robust fluorescence readout of the MBs. Firstly, target miRNA can initiate CLCR on the surface of MBs based on the click chemical ligation between dibenzocyclooctyne (DBCO)- and azide-modified single-stranded DNA (ssDNA) probes, and the amount of ligated ssDNA sequences on the MBs will be proportional to the dosage of target miRNA...
July 24, 2017: Analyst
https://www.readbyqxmd.com/read/28736759/forecasted-trends-in-disability-and-life-expectancy-in-england-and-wales-up-to-2025-a-modelling-study
#14
Maria Guzman-Castillo, Sara Ahmadi-Abhari, Piotr Bandosz, Simon Capewell, Andrew Steptoe, Archana Singh-Manoux, Mika Kivimaki, Martin J Shipley, Eric J Brunner, Martin O'Flaherty
BACKGROUND: Reliable estimation of future trends in life expectancy and the burden of disability is crucial for ageing societies. Previous forecasts have not considered the potential impact of trends in disease incidence. The present prediction model combines population trends in cardiovascular disease, dementia, disability, and mortality to forecast trends in life expectancy and the burden of disability in England and Wales up to 2025. METHODS: We developed and validated the IMPACT-Better Ageing Model-a probabilistic model that tracks the population aged 35-100 years through ten health states characterised by the presence or absence of cardiovascular disease, dementia, disability (difficulty with one or more activities of daily living) or death up to 2025, by use of evidence-based age-specific, sex-specific, and year-specific transition probabilities...
July 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28736637/primary-and-acquired-resistance-to-biologic-therapies-in-gastrointestinal-cancers
#15
REVIEW
Sam J Lubner, Nataliya V Uboha, Dustin A Deming
Improvements in the understanding of cancer biology have led to therapeutic advances in the treatment of gastrointestinal cancers. Drugs which target the vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) pathways have led the way in colon cancer. Monoclonal antibodies (mAbs) such as bevacizumab, ramucirumab, cetuximab, and panitumumab, have improved progression free survival and overall survival (OS) for colorectal cancers and were quickly adopted. Human epidermal growth factor receptor 2 (HER2) has demonstrated significant benefit for gastroesophageal cancers and in the setting of HER2 amplification, trastuzumab in combination with chemotherapy has become the standard of care...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736633/biologics-in-gastrointestinal-and-pancreatic-neuroendocrine-tumors
#16
REVIEW
Iris H Liu, Pamela L Kunz
The development of biologic agents has ushered in a new era of precision medicine, opening the door to new therapeutic options designed to intelligently target cancer cells and their promoting factors, while leaving normal cells relatively unharmed. Biologics for the treatment of neuroendocrine tumors (NETs) have followed in the footsteps of regimens targeting pathways upregulated in other cancers, including the vascular endothelial growth factor (VEGF) and the mammalian target of rapamycin (mTOR). Through a number of clinical trials, the mTOR inhibitor everolimus and the receptor tyrosine kinase (RTK) inhibitor sunitinib were recently approved for NETs...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736629/biologic-therapy-in-esophageal-and-gastric-malignancies-current-therapies-and-future-directions
#17
REVIEW
Pamela Samson, A Craig Lockhart
Biologic agents, including targeted antibodies as well as immunomodulators, are demonstrating unparalleled development and study across the entire spectrum of human malignancy. This review summarizes the current state of biologic therapies for esophageal, esophagogastric, and gastric malignancies, including those that target human epidermal growth factor receptor 2 (HER2), epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), c-Met, mechanistic target of rapamycin (mTOR) and immunomodulators...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736627/personalized-and-precision-medicine-integrating-genomics-into-treatment-decisions-in-gastrointestinal-malignancies
#18
REVIEW
Trang H Au, Kai Wang, David Stenehjem, Ignacio Garrido-Laguna
The advent of next generation sequencing (NGS) technologies has advanced our understanding of the intrinsic biology of different gastrointestinal (GI) tumor types. The use of novel, more efficient sequencing platforms has improved turnaround times of sequencing results. This is providing real time opportunities to put precision medicine to the test. A number of early phase clinical trials are testing targeted therapies in unique molecularly characterized subsets of patients (baskets). While basket studies are gaining momentum, treatment failures serve to remind us that shifting from a histology-driven to a histology-agnostic approach is unlikely to be a failure-free strategy for a number of tumor types as recently learnt from vemurafenib failure in BRAF mutated metastatic colorectal cancer (mCRC)...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736537/the-five-marks-of-the-mental
#19
REVIEW
Tuomas K Pernu
The mental realm seems different to the physical realm; the mental is thought to be dependent on, yet distinct from the physical. But how, exactly, are the two realms supposed to be different, and what, exactly, creates the seemingly insurmountable juxtaposition between the mental and the physical? This review identifies and discusses five marks of the mental, features that set characteristically mental phenomena apart from the characteristically physical phenomena. These five marks (intentionality, consciousness, free will, teleology, and normativity) are not presented as a set of features that define mentality...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28736252/systemic-therapy-following-metastasectomy-for-renal-cell-carcinoma-using-insights-from-other-clinical-settings-to-address-unanswered-questions
#20
REVIEW
Leonard J Appleman, Jodi K Maranchie
Surgical resection for metastatic renal cell carcinoma (RCC) was first described several decades ago, but the appropriate role for surgery in coordinated multidisciplinary care has not been well-defined. The explosive development of new therapies for advanced RCC over the past 10 years has improved the outlook for patients, and there is now renewed interest in surgical metastasectomy for selected patients with metastatic RCC, moving away from the conventional dichotomy between surgery for local disease and systemic therapy for metastatic disease...
July 20, 2017: Urologic Oncology
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