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https://www.readbyqxmd.com/read/29783161/candidate-gene-analysis-in-the-s%C3%A3-o-paulo-epidemiologic-sleep-study-episono-shows-an-association-of-variant-in-pde4d-and-sleepiness
#1
Victoria M Pak, Diego R Mazzotti, Brendan T Keenan, Camila Hirotsu, Philip Gehrman, Lia Bittencourt, Allan I Pack, Sergio Tufik
INTRODUCTION: Sleepiness and cardiovascular disease share common molecular pathways; thus, genetic risk factors for sleepiness may also predict cardiovascular disease risk. This study explored the associations between subjective sleepiness and single-nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory, and neuronal pathways, which may contribute to sleepiness and downstream cardiovascular disease risk: Cytochrome B-245, Alpha Polypeptide (CYBA), Cytochrome B-245, Beta Polypeptide (CYBB), Neutrophil Cytosolic Factor (NCF2), Tumor Necrosis Factor-Alpha (TNFA), and Phosphodiesterase 4D (PDE4D)...
January 12, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29783009/antiplatelet-medication-reversal-strategies-in-operative-intracranial-hemorrhage-a-survey-of-practicing-neurosurgeons
#2
Paul M Foreman, Adeel Ilyas, James Mooney, Philip G R Schmalz, Beverly C Walters, Christoph J Griessenauer
OBJECTIVE: Antiplatelet therapy is common and complicates the operative management of acute intracranial hemorrhage. Little data exist to guide antiplatelet reversal strategies. METHODS: An online survey detailing antiplatelet reversal strategies in patients presenting with acute operative intracranial hemorrhage (subdural hematoma (SDH), epidural hematoma (EDH), and intracerebral hemorrhage (ICH) was distributed to board certified neurosurgeons in the North America...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29782998/measurement-of-salivary-pepsin-for-diagnosis-of-gerd-in-adults-and-children-is-not-yet-ready-for-clinical-application
#3
Philip Woodland, Maartje Mj Singendonk, Joanne Ooi, Kornilia Nikaki, Terry Wong, Chung Lee, Esteban Glasinovic, Romy Koning, Rene Lutter, Marc A Benninga, Michiel P van Wijk, Daniel Sifrim
No abstract text is available yet for this article.
May 18, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29782895/detection-of-il-36y-via-non-invasive-tape-stripping-reliably-discriminates-psoriasis-from-atopic-eczema
#4
Anna Berekméri, Anne Latzko, Adewonuola Alase, Tom Macleod, Joseph S Ainscough, Philip Laws, Mark Goodfield, Andrew Wright, Philip Helliwell, Sara Edward, Gordon D Brown, Delyth M Reid, Joerg Wenzel, Martin Stacey, Miriam Wittmann
This report demonstrates that sampling and detection of IL-36γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.
May 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29782794/peptides-peptidomimetics-and-carbohydrate-peptide-conjugates-as-amyloidogenic-aggregation-inhibitors-for-alzheimer-s-disease
#5
Philip Ryan, Bhautikkumar Patel, Vivek Makwana, Hemant Jadhav, Milton John Kiefel, Andrew Davey, Tristan Reekie, Santosh Rudrawar, Michael Kassiou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for 60-80% of dementia cases. For many years, AD causality was attributed to amyloid-β (Aβ) aggregated species. Recently, multiple therapies that target Aβ aggregation have failed in clinical trials, since Aβ aggregation is found in AD and healthy patients. Attention has therefore shifted towards the aggregation of the peptide tau as a major driver of AD. Numerous inhibitors of tau-based pathology have recently been developed...
May 21, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29782652/adenosine-methylation-as-a-molecular-imprint-defining-the-fate-of-rna
#6
REVIEW
Philip Knuckles, Marc Bühler
Multiple lines of evidence suggest the RNA modification N6 -methyladonsine (m6 A), which is installed in the nucleus co-transcriptionally and, thereafter, serves as a reversible chemical imprint that influences several steps of mRNA metabolism. This includes but is not limited to RNA folding, splicing, stability, transport, and translation. In this Review we focus on the current view of the nuclear installation of m6 A as well the molecular players involved, the so called m6 A writers. We also explore the effector proteins, or m6 A readers, that decode the imprint in different cellular contexts and compartments, and ultimately, the way the modification influences the lifecycle of an RNA molecule...
May 21, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29782553/correction-electrocardiographic-biomarkers-for-detection-of-drug-induced-late-sodium-current-block
#7
Jose Vicente, Lars Johannesen, Meisam Hosseini, Jay W Mason, Philip T Sager, Esther Pueyo, David G Strauss
[This corrects the article DOI: 10.1371/journal.pone.0163619.].
2018: PloS One
https://www.readbyqxmd.com/read/29782405/the-impact-of-anesthesia-influenced-process-measure-compliance-on-length-of-stay-results-from-an-enhanced-recovery-after-surgery-for-colorectal-surgery-cohort
#8
Michael C Grant, Claro M Pio Roda, Joseph K Canner, Philip Sommer, Daniel Galante, Deborah Hobson, Susan Gearhart, Christopher L Wu, Elizabeth Wick
BACKGROUND: Process measure compliance has been associated with improved outcomes in enhanced recovery after surgery (ERAS) programs. Herein, we sought to assess the impact of compliance with measures directly influenced by anesthesiology in an ERAS for colorectal surgery cohort. METHODS: From January 2013 to April 2015, data from 1140 consecutive patients were collected for all patients before (pre-ERAS) and after (ERAS) implementation of an ERAS program. Compliance with 9 specific process measures directly influenced by the anesthesiologist or acute pain service was analyzed to determine the impact on hospital length of stay (LOS)...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29781964/influencing-health-behavior-change-related-to-musculoskeletal-conditions-the-need-to-expand-the-evidence-base-and-the-case-for-multi-theory-model-mtm
#9
Richard W Kim, Philip M Stephens, Vinayak K Nahar, Manoj Sharma
No abstract text is available yet for this article.
May 17, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29781626/on-selecting-evidence-to-test-hypotheses-a-theory-of-selection-tasks
#10
Marco Ragni, Ilir Kola, Philip N Johnson-Laird
How individuals choose evidence to test hypotheses is a long-standing puzzle. According to an algorithmic theory that we present, it is based on dual processes: individuals' intuitions depending on mental models of the hypothesis yield selections of evidence matching instances of the hypothesis, but their deliberations yield selections of potential counterexamples to the hypothesis. The results of 228 experiments using Wason's selection task corroborated the theory's predictions. Participants made dependent choices of items of evidence: the selections in 99 experiments were significantly more redundant (using Shannon's measure) than those of 10,000 simulations of each experiment based on independent selections...
May 21, 2018: Psychological Bulletin
https://www.readbyqxmd.com/read/29781524/tgf-%C3%AE-signalling-in-renal-fibrosis-from-smads-to-non-coding-rnas
#11
Patrick Ming-Kuen Tang, Ying-Ying Zhang, Thomas Shiu-Kwong Mak, Philip Chiu-Tsun Tang, Xiao-Ru Huang, Hui-Yao Lan
Transforming growth factor-β (TGF-β) is the key player in tissue fibrosis. However, antifibrotic therapy targeting this multifunctional protein may interfere other physiological processes to cause side effects. Thus, precise therapeutic targets are needed to be identified by further understanding the underlying mechanisms of TGF-β1 signalling during fibrogenesis. Equilibrium of Smad signalling is crucial for TGF-β-mediated renal fibrosis, where Smad3 is pathogenic but Smad2 and Smad7 are protective. The activation of TGF-β1/Smad signalling triggers extracellular matrix deposition, and local myofibroblast generation and activation...
May 21, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29781325/is-it-clinically-defensible-to-treat-children-longer-term-with-second-generation-antipsychotics
#12
Philip Hazell
No abstract text is available yet for this article.
May 21, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29780921/is-it-melanoma-associated-retinopathy-or-drug-toxicity-bilateral-cystoid-macular-edema-posing-a-diagnostic-and-therapeutic-dilemma
#13
Sachi R Patel, Stavros N Moysidis, Nicole Koulisis, Philip P Storey, Amir H Kashani, Narsing A Rao, Damien C Rodger
Purpose: To report the clinical presentation, multimodal imaging, and management of a patient with metastatic melanoma who presented with cystoid macular edema (CME). Observations: We report a case of a 71-year-old Caucasian male with metastatic melanoma who presented with bilateral cystoid macular edema after being on treatment with a programmed T cell death ligand 1 inhibitor, MPDL3280, for 1 year. Multimodal imaging techniques, including color fundus photographs, autofluorescence, spectral domain optical coherence tomography (OCT), fluorescein angiography (Spectralis, Heidelberg, Germany), and spectral-domain OCT angiography (Zeiss; California, USA) were performed to evaluate the etiology of his CME and to monitor his response to treatment...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780863/a-novel-cognitive-functional-composite-measure-to-detect-changes-in-early-alzheimer-s-disease-test-retest-reliability-and-feasibility
#14
Roos J Jutten, John Harrison, Philippe R Lee Meeuw Kjoe, Esther M Opmeer, Niki S M Schoonenboom, Frank Jan de Jong, Craig W Ritchie, Philip Scheltens, Sietske A M Sikkes
Introduction: To improve the detection of changes in Alzheimer's disease (AD), we designed the cognitive-functional composite (CFC). As a first validation step, we investigated its test-retest reliability and feasibility of use. Methods: We performed a test-retest study with 2-3 weeks between assessments, including patients with mild cognitive impairment (MCI) or mild AD dementia and cognitively healthy participants. We calculated intraclass correlation coefficients (ICCs) type absolute agreement for all CFC measures and compared baseline and retest scores using paired-samples t -tests...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780860/microbleeds-are-associated-with-depressive-symptoms-in-alzheimer-s-disease
#15
Anna E Leeuwis, Niels D Prins, Astrid M Hooghiemstra, Marije R Benedictus, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flier
Introduction: Co-occurrence of cerebrovascular disease and depression led to the "vascular depression hypothesis". White matter hyperintensities (WMHs) have been associated with depressive symptoms in population-based studies. We studied the association between small vessel disease and depressive symptoms in a memory clinic population. Methods: We included >2000 patients with subjective cognitive decline (SCD), mild cognitive impairment, and Alzheimer's disease (AD)...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780849/incidental-findings-on-coronary-computed-tomography-angiography-in-human-immunodeficiency-virus-hiv-positive-and-hiv-negative-persons
#16
Sara Reinschmidt, Teja Turk, Philip E Tarr, Roger Kouyos, Christoph Hauser, Patrick Schmid, Rainer Weber, Philipp Kaufmann, Ronny R Buechel, Helen Kovari
Background: Incidental findings on coronary computed tomography angiography (CCTA) have a great impact on the benefits and costs of testing for cardiovascular disease. The number of incidental findings might be increased in human immunodeficiency virus (HIV)-positive individuals compared with the general population. Data are limited regarding the association between incidental findings and HIV infection. Methods: We assessed the prevalence and factors associated with incidental findings among HIV-positive and HIV-negative participants ≥45 years undergoing CCTA...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29780810/factors-associated-with-bites-to-a-child-from-a-dog-living-in-the-same-home-a-bi-national-comparison
#17
Locksley L McV Messam, Philip H Kass, Bruno B Chomel, Lynette A Hart
We conducted a veterinary clinic-based retrospective cohort study aimed at identifying child-, dog-, and home-environment factors associated with dog bites to children aged 5-15 years old living in the same home as a dog in Kingston, Jamaica (236) and San Francisco, USA (61). Secondarily, we wished to compare these factors to risk factors for dog bites to the general public. Participant information was collected via interviewer-administered questionnaire using proxy respondents. Data were analyzed using log-binomial regression to estimate relative risks and associated 95% confidence intervals (CIs) for each exposure-dog bite relationship...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29780025/neighbourhood-socioeconomic-position-and-risks-of-major-chronic-diseases-and-all-cause-mortality-a-quasi-experimental-study
#18
Daniel Kim, Richard H Glazier, Brandon Zagorski, Ichiro Kawachi, Philip Oreopoulos
OBJECTIVES: This study estimated the health impacts of neighbourhood socioeconomic position (SEP) among public housing residents. Because applicants to public housing were assigned to housing projects primarily based on factors other than personal choice, we capitalised on a quasirandom source of variation in neighbourhood of residence to obtain more valid estimates of the health impacts of neighbourhood SEP. DESIGN: Quasiexperimental study. SETTING: Greater Metropolitan Toronto area, Canada...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29779997/variations-in-time-to-benefit-among-clinical-trials-of-cholesterol-lowering-drugs
#19
Philip J Barter, David D Waters
BACKGROUND: Time to benefit (TTB) in clinical trials of cholesterol-lowering drugs is important because it may provide a clue as to the potential mechanism of action of the drug, it is helpful in determining when to stop a trial for futility, and it may inform treatment decisions in subjects with reduced life expectancy. OBJECTIVE: To compare TTB among clinical trials of cholesterol-lowering drugs. METHODS: We examined TTB in 24 trials of cholesterol-lowering drugs with positive outcomes...
April 21, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29779899/signaling-dependent-control-of-apical-membrane-size-and-self-renewal-in-rosette-stage-human-neuroepithelial-stem-cells
#20
Jan-Philip Medelnik, Kathleen Roensch, Satoshi Okawa, Antonio Del Sol, Osvaldo Chara, Levan Mchedlishvili, Elly M Tanaka
In the developing nervous system, neural stem cells are polarized and maintain an apical domain facing a central lumen. The presence of apical membrane is thought to have a profound influence on maintaining the stem cell state. With the onset of neurogenesis, cells lose their polarization, and the concomitant loss of the apical domain coincides with a loss of the stem cell identity. Little is known about the molecular signals controlling apical membrane size. Here, we use two neuroepithelial cell systems, one derived from regenerating axolotl spinal cord and the other from human embryonic stem cells, to identify a molecular signaling pathway initiated by lysophosphatidic acid that controls apical membrane size and consequently controls and maintains epithelial organization and lumen size in neuroepithelial rosettes...
May 10, 2018: Stem Cell Reports
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