keyword
MENU ▼
Read by QxMD icon Read
search

Philips

keyword
https://www.readbyqxmd.com/read/28934507/a-comprehensive-cell-specific-microrna-catalogue-of-human-peripheral-blood
#1
Simonas Juzenas, Geetha Venkatesh, Matthias Hübenthal, Marc P Hoeppner, Zhipei Gracie Du, Maren Paulsen, Philip Rosenstiel, Philipp Senger, Martin Hofmann-Apitius, Andreas Keller, Limas Kupcinskas, Andre Franke, Georg Hemmrich-Stanisak
With this study, we provide a comprehensive reference dataset of detailed miRNA expression profiles from seven types of human peripheral blood cells (NK cells, B lymphocytes, cytotoxic T lymphocytes, T helper cells, monocytes, neutrophils and erythrocytes), serum, exosomes and whole blood. The peripheral blood cells from buffy coats were typed and sorted using FACS/MACS. The overall dataset was generated from 450 small RNA libraries using high-throughput sequencing. By employing a comprehensive bioinformatics and statistical analysis, we show that 3' trimming modifications as well as composition of 3' added non-templated nucleotides are distributed in a lineage-specific manner-the closer the hematopoietic progenitors are, the higher their similarities in sequence variation of the 3' end...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934228/knowledge-about-tuberculosis-transmission-and-prevention-and-perceptions-of-health-service-utilization-among-index-cases-and-contacts-in-brazil-understanding-losses-in-the-latent-tuberculosis-cascade-of-care
#2
Flavia Matos Salame, Márcia Danielle Ferreira, Marcia Teresa Belo, Eleny Guimarães Teixeira, Marcelo Cordeiro-Santos, Ricardo Arraes Ximenes, Maria de Fátima Militão de Albuquerque, Philip C Hill, Dick Menzies, Anete Trajman
INTRODUCTION: Tuberculosis contacts are candidates for active and latent tuberculosis infection screening and eventual treatment. However, many losses occur in the different steps of the contacts' cascade of care. Reasons for this are poorly understood. OBJECTIVE: To describe the different steps where losses in the contact cascade occur and to explore knowledge and attitudes regarding tuberculosis transmission/prevention and perceptions about tuberculosis services in order to understand the reasons for losses from the tuberculosis service users' perspective...
2017: PloS One
https://www.readbyqxmd.com/read/28934202/platelet-dysfunction-contributes-to-bleeding-complications-in-patients-with-probable-leptospirosis
#3
Rahajeng N Tunjungputri, Muhammad Hussein Gasem, Willemijn van der Does, Pandu H Sasongko, Bambang Isbandrio, Rolf T Urbanus, Philip G de Groot, Andre van der Ven, Quirijn de Mast
BACKGROUND: Severe leptospirosis is frequently complicated by a hemorrhagic diathesis, of which the pathogenesis is still largely unknown. Thrombocytopenia is common, but often not to the degree that spontaneous bleeding is expected. We hypothesized that the hemorrhagic complications are not only related to thrombocytopenia, but also to platelet dysfunction, and that increased binding of von Willebrand factor (VWF) to platelets is involved in both platelet dysfunction and increased platelet clearance...
September 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28934181/notes-from-the-field-increase-in-reported-hepatitis-a-infections-among-men-who-have-sex-with-men-new-york-city-january-august-2017
#4
Julia Latash, Marie Dorsinville, Paula Del Rosso, Mike Antwi, Vasudha Reddy, HaeNa Waechter, Jacqueline Lawler, Heather Boss, Philip Kurpiel, P Bryon Backenson, Charles Gonzalez, Shannon Rowe, Tasha Poissant, Yulin Lin, Guo-Liang Xia, Sharon Balter
Since 2011, the New York City (NYC) Department of Health and Mental Hygiene (DOHMH) has typically been notified of three or fewer cases of hepatitis A virus (HAV) infection each year among men who have sex with men (MSM) who reported no travel to countries where HAV is endemic. This year, DOHMH noted an increase in HAV infections among MSM with onsets in January-March 2017, and notified other public health jurisdictions via Epi-X, CDC's communication exchange network. As a result, 51 patients with HAV infection involving MSM were linked to the increase in NYC...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934167/live-attenuated-influenza-vaccine-contains-substantial-and-unexpected-amounts-of-defective-viral-genomic-rna
#5
Philip S Gould, Andrew J Easton, Nigel J Dimmock
The live attenuated influenza vaccine FluMist(®) was withdrawn in the USA by the Centers for Disease Control and Prevention after its failure to provide adequate protective immunity during 2013-2016. The vaccine uses attenuated core type A and type B viruses, reconfigured each year to express the two major surface antigens of the currently circulating viruses. Here Fluenz™ Tetra, the European version of this vaccine, was examined directly for defective-interfering (DI) viral RNAs. DI RNAs are deleted versions of the infectious virus genome, and have powerful biological properties including attenuation of infection, reduction of infectious virus yield, and stimulation of some immune responses...
September 21, 2017: Viruses
https://www.readbyqxmd.com/read/28934137/evidence-for-involvement-of-il-9-and-il-22-in-cows-milk-allergy-in-infants
#6
Karina V Barros, Vera L Flor Silveira, Marisa S Laranjeira, Neusa F Wandalsen, Susana Passeti, Roberta de Oliveira, Regina V Munekata, Paul S Noakes, Elizabeth A Miles, Philip C Calder
Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20)...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28934113/sphingosine-1-phosphate-signaling-and-its-pharmacological-modulation-in-allogeneic-hematopoietic-stem-cell-transplantation
#7
REVIEW
Philip Smith, Catherine O'Sullivan, Peter Gergely
Allogeneic haemopoietic stem cell transplantation (HSCT) is increasingly used to treat haematological malignant diseases via the graft-versus-leukaemia (GvL) or graft-versus-tumour effects. Although improvements in infectious disease prophylaxis, immunosuppressive treatments, supportive care, and molecular based tissue typing have contributed to enhanced outcomes, acute graft-versus-host disease and other transplant related complications still contribute to high mortality and significantly limit the more widespread use of HSCT...
September 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28933826/a-modern-twist-to-a-classic-synthetic-route-ph3bi-based-redox-transmetalation-protolysis-rtp-for-the-preparation-of-barium-metalorganic-species
#8
Yuriko Takahashi, Anna O'Brien, Glen B Deacon, Philip C Andrews, Melanie Wolf, Ana Torvisco, Miriam M Gillett-Kunnath, Karin Ruhlandt-Senge
This paper reports advances in redox transmetalation/protolysis (RTP) utilizing the readily available Ph3Bi for the synthesis of a series of barium metal-organic species. On the basis of easily available starting materials, an easy one-pot procedure, and workup, we have obtained BaL2 compounds (L = bis(trimethylsilyl)amide, phenyl(trimethylsilyl)amide, pentamethylcyclopentadienide, fluorenide, 2,6-di-isopropylphenolate, and 3,5-diphenylpyrazolate) quantitatively by sonication of an excess of barium metal with triphenylbismuth and HL in perdeuterotetrahydrofuran, as established by NMR measurements...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933715/rating-of-perceived-exertion-for-quantification-of-training-and-combat-loads-during-combat-sport-specific-activities-a-short-review
#9
Maamer Slimani, Philip Davis, Emerson Franchini, Wassim Moalla
Slimani, M, Davis, P, Franchini, E, and Moalla, W. Rating of perceived exertion for quantification of training and combat loads during combat sport-specific activities: a short review. J Strength Cond Res 31(10): 2889-2902, 2017-The aim of this short review was to summarize data pertaining to the rating of perceived exertion (RPE) methods (RPE value and session-RPE) during combat sport-specific activities (i.e., competition and training) based on many factors, including contest type (i.e., official vs. simulated vs...
October 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28933657/a-novel-immunization-approach-for-dengue-infection-based-on-conserved-t-cell-epitopes-formulated-in-calcium-phosphate-nanoparticles
#10
Xiaofang Huang, Aykan Karabudak, Joseph D Comber, Mohan Philip, Tulin Morcol, Ramila Philip
Dengue virus (DV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Most DV vaccine approaches are focused on generating antibody mediated responses; one such DV vaccine is approved for use in humans but its efficacy is limited. While it is clear that T cell responses play important role in DV infection and subsequent disease manifestations, fewer studies are aimed at developing vaccines that induce robust T cells responses. Potent T cell based vaccines require two critical components: the identification of specific T cell stimulating MHC associated peptides, and an optimized vaccine delivery vehicle capable of simultaneously delivering the antigens and any required adjuvants...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933531/room-temperature-activation-of-ingazno-thin-film-transistors-via-he-irradiation
#11
Michael G Stanford, Joo Hyon Noh, Kyle Mahady, Anton V Ievlev, Petro Maksymovych, Olga S Ovchinnikova, Philip D Rack
Amorphous indium gallium zinc oxide (a-IGZO) is a transparent semiconductor which has demonstrated excellent electrical performance as thin film transistors (TFTs). However, a high-temperature activation process is generally required which is incompatible for next-generation flexible electronic applications. In this work, He(+) irradiation is demonstrated as an athermal activation process for a-IGZO TFTs. Controlling He+ dose enables the tuning of charge density and a dose of 1×10(14) He(+)/cm(2) induces a change in charge density of 2...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28933288/stem-cell-differentiation-stage-factors-and-their-role-in-triggering-symmetry-breaking-processes-during-cancer-development-a-quantum-field-theory-model-for-reprogramming-cancer-cells-to-healthy-phenotypes
#12
Pier Mario Biava, Fabio Burigana, Roberto Germano, Philip Kurian, Claudio Verzegnassi, Giuseppe Vitiello
A long history of research has pursued the use of embryonic factors isolated during cell differentiation processes for the express purpose of transforming cancer cells back to healthy phenotypes. Recent results have clarified that the substances present at different stages of cell differentiation-which we call stem cell differentiation stage factors (SCDSFs)-are proteins with low molecular weight and nucleic acids that regulate genomic expression. The present review summarizes how these substances, taken at different stages of cellular maturation, are able to retard proliferation of many human tumor cell lines and thereby reprogram cancer cells to healthy phenotypes...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28932925/hepatic-complications-of-anorexia-nervosa
#13
REVIEW
Elissa Rosen, Neeru Bakshi, Ashlie Watters, Hugo R Rosen, Philip S Mehler
Anorexia nervosa (AN) has the highest mortality rate of all psychiatric illnesses due to the widespread organ dysfunction caused by the underlying severe malnutrition. Starvation causes hepatocyte injury and death leading to a rise in aminotransferases. Malnutrition-induced hepatitis is common among individuals with AN especially as body mass index decreases. Acute liver failure associated with coagulopathy and encephalopathy can rarely occur. Liver enzymes may also less commonly increase as part of the refeeding process due to hepatic steatosis and can be distinguished from starvation hepatitis by the finding of a fatty liver on ultrasonography...
September 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28932826/interobserver-variation-of-the-bolus-and-burst-method-for-pancreatic-perfusion-with-dynamic-contrast-enhanced-ultrasound
#14
Marcus Stangeland, Trond Engjom, Martin Mezl, Radovan Jirik, Odd Helge Gilja, Georg Dimcevski, Kim Nylund
PURPOSE: Dynamic contrast-enhanced ultrasound (DCE-US) can be used for calculating organ perfusion. By combining bolus injection with burst replenishment, the actual mean transit time (MTT) can be estimated. Blood volume (BV) can be obtained by scaling the data to a vessel on the imaging plane. The study aim was to test interobserver agreement for repeated recordings using the same ultrasound scanner and agreement between results on two different scanner systems. MATERIALS AND METHODS: Ten patients under evaluation for exocrine pancreatic failure were included...
June 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28932809/aberrant-cortical-activity-in-multiple-gcamp6-expressing-transgenic-mouse-lines
#15
Nicholas A Steinmetz, Christina Buetfering, Jerome Lecoq, Christian R Lee, Andrew J Peters, Elina A K Jacobs, Philip Coen, Douglas R Ollerenshaw, Matthew T Valley, Saskia E J de Vries, Marina Garrett, Jun Zhuang, Peter A Groblewski, Sahar Manavi, Jesse Miles, Casey White, Eric Lee, Fiona Griffin, Joshua D Larkin, Kate Roll, Sissy Cross, Thuyanh V Nguyen, Rachael Larsen, Julie Pendergraft, Tanya Daigle, Bosiljka Tasic, Carol L Thompson, Jack Waters, Shawn Olsen, David J Margolis, Hongkui Zeng, Michael Hausser, Matteo Carandini, Kenneth D Harris
Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. Here we report aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors. These epileptiform events have been observed particularly, but not exclusively, in mice with Emx1-Cre and Ai93 transgenes, of either sex, across multiple laboratories...
September 2017: ENeuro
https://www.readbyqxmd.com/read/28932711/molecular-characterization-of-antimicrobial-resistance-in-clinical-shigella-isolates-during-2014-and-2015-trends-in-south-india
#16
Shalini Anandan, Dhiviya Prabaa Muthuirulandi Sethuvel, Revathi Gajendiren, Valsan Philip Verghese, Kamini Walia, Balaji Veeraraghavan
BACKGROUND: Shigella species are an important cause of acute diarrheal disease worldwide. This study describes the prevalence of Shigella spp. serotypes and their resistance profile in Vellore, South India from 2014 to 2015. METHODS: From 2014 to 2015, 338 Shigella strains were isolated from stool samples at Christian Medical College, Vellore, India. Identification and serotyping was carried out using standard protocols. Antimicrobial susceptibility testing was done against commonly used antibiotics...
September 2017: Germs
https://www.readbyqxmd.com/read/28932494/nanotechnology-advancing-the-translational-respiratory-research
#17
Kamal Dua, Shakti Dhar Shukla, Terezinha de Jesus Andreoli Pinto, Philip Michael Hansbro
Considering the various limitations associated with the conventional dosage forms, nanotechnology is gaining increased attention in drug delivery particularly in respiratory medicine and research because of its advantages like targeting effects, improved pharmacotherapy, and patient compliance. This paper provides a quick snapshot about the recent trends and applications of nanotechnology to various translational and formulation scientists working on various respiratory diseases, which can help paving a new path in developing effective drug delivery system...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28931194/intracapsular-tonsillectomy-for-keratosis-pharyngeous-a-pilot-study-of-postoperative-recovery-and-surgical-efficacy
#18
Philip A Gaudreau, Eric M Gessler
Our objective was to perform a pilot study comparing intracapsular radiofrequency ablation tonsillectomy with subcapsular tonsillectomy in adult patients with keratosis pharyngeous. Patients diagnosed with keratosis pharyngeous between December 2010 and February 2013 were randomized to undergo either intracapsular or subcapsular tonsillectomy using radiofrequency ablation. Postoperative pain scores and amount of pain medication taken were recorded for 2 weeks. A 6-month follow-up questionnaire was used to assess efficacy of the procedure...
September 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28930965/bayesian-clinical-trial-designs-another-option-for-trauma-trials
#19
Jan O Jansen, Philip Pallmann, Graeme MacLennan, Marion K Campbell
Conducting clinical trials in trauma care is challenging. As new treatments become available, we are faced with the dilemma of how to confirm their effectiveness and strengthen the evidence base. Randomized controlled trials are the criterion standard, but target groups in trauma care are often small and specialized, making the classic approach to trial design difficult. Bayesian designs represent an innovative means of increasing trial efficiency and conducting trials with more realistic sample sizes. This article examines the design of such trials, using the UK-REBOA Trial as an example...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930658/defined-sensing-mechanisms-and-signaling-pathways-contribute-to-the-global-inflammatory-gene-expression-output-elicited-by-ionizing-radiation
#20
Prabhat K Purbey, Philip O Scumpia, Peter J Kim, Ann-Jay Tong, Keisuke S Iwamoto, William H McBride, Stephen T Smale
Environmental insults are often detected by multiple sensors that activate diverse signaling pathways and transcriptional regulators, leading to a tailored transcriptional output. To understand how a tailored response is coordinated, we examined the inflammatory response elicited in mouse macrophages by ionizing radiation (IR). RNA-sequencing studies revealed that most radiation-induced genes were strongly dependent on only one of a small number of sensors and signaling pathways, notably the DNA damage-induced kinase ATM, which regulated many IR-response genes, including interferon response genes, via an atypical IRF1-dependent, STING-independent mechanism...
September 19, 2017: Immunity
keyword
keyword
42266
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"