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https://www.readbyqxmd.com/read/28445789/characterisation-of-pb-induced-changes-and-prediction-of-pb-exposure-in-microalgae-using-infrared-spectroscopy
#1
Ly Dao, John Beardall, Philip Heraud
Macromolecular changes in Chlorella sp. FleB1 and Scenedesmus acutus YaA6 exposed to Pb were characterised by Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy. Spectra were collected in the mid-infrared spectral region and a chemometric approach was used to analyse the spectra. Principal Component Analysis showed that under Pb treatment, carbohydrates and lipids increased while proteins and phosphorylated molecules decreased in both the isolates. These conclusions were corroborated by conventional measurements of photosynthesis and neutral lipids...
April 14, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28445644/broadband-fluorescence-enhancement-with-self-assembled-silver-nanoparticle-optical-antennas
#2
Carolin Vietz, Izabela Kaminska, Maria Sanz Paz, Philip Tinnefeld, Guillermo P Acuna
Plasmonic structures are known to affect the fluorescence properties of dyes placed in close proximity. This effect has been exploited in combination with single-molecule techniques for several applications in the field of biosensing. Among these plasmonic structures, top-down zero mode waveguides stand out due to their broadband capabilities. In contrast, optical antennas based on gold nanostructures exhibit fluorescence enhancement on a narrow fraction of the visible spectrum typically restricted to the red to near-infrared region...
April 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28445072/an-approach-to-the-core-of-lactonamycin
#3
Philip J Parsons, Daniel R Jones, Lee J Walsh, Lewis A T Allen, Ada Onwubiko, Lewis Preece, Johnathan Board, Andrew J P White
A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent lactonamycin Z.
April 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/28445068/experimental-demonstration-of-230%C3%A2-phase-modulation-in-gate-tunable-graphene-gold-reconfigurable-mid-infrared-metasurfaces
#4
Michelle C Sherrott, Philip W C Hon, Katherine T Fountaine, Juan C Garcia, Samuel M Ponti, Victor Watson Brar, Luke A Sweatlock, Harry A Atwater
Metasurfaces offer significant potential to control far-field light propagation through the engineering of amplitude, polarization, and phase at an interface. We report here phase modulation of an electronically reconfigurable metasurface and demonstrate its utility for mid-infrared beam steering. Using a gate-tunable graphene-gold resonator geometry, we demonstrate highly tunable reflected phase at multiple wavelengths and show up to 237° phase modulation range at an operating wavelength of 8.50 μm. We observe a smooth monotonic modulation of phase with applied voltage from 0° to 206° at a wavelength of 8...
April 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28445052/facile-preparation-of-drug-loaded-tristearin-encapsulated-superparamagnetic-iron-oxide-nanoparticles-using-coaxial-electrospray-processing
#5
Manoochehr Rasekh, Zeeshan Ahmad, Richard Barrie Michael Cross, Javier Hernández Gil, James D E T Wilton-Ely, Philip W Miller
Naturally occurring polymers are promising biocompatible materials that have many applications for emerging therapies, drug delivery systems and diagnostic agents. The handling and processing of such materials still constitutes a major challenge which can limit the full exploitation of their properties. This study explores an ambient environment processing technique: coaxial electrospray (CO-ES) to encapsulate genistein (an isoflavonoid and model drug), superparamagnetic iron oxide nanoparticles (SPIONs, 10-15 nm) and a fluorophore (BODIPY) into a layered (triglyceride tristearin shell) particulate system, with a view to constructing a theranostic agent...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28444896/agreement-between-finger-plethysmography-and-brachial-oscillometry-derived-blood-pressure-measurements
#6
Philip D Allan, Terrence O'Donnell, Yu-Chieh Tzeng
PURPOSE: Blood pressure (BP) is commonly assessed by brachial oscillometry in clinical practice, whereas in physiological studies, finger plethysmography is often employed. This study assessed the limits of agreement between BP metrics obtained from each device. METHODS: In 96 participants, we simultaneously recorded BP by brachial oscillometry (BP+; Uscom, Sydney, NSW, Australia) and finger plethysmography (Finometer MIDI, MLE1054-V; Finapres Medical Systems B...
April 26, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28444492/optimal-radial-force-and-size-for-palliation-in-gastroesophageal-adenocarcinoma-a-comparative-analysis-of-current-stent-technology
#7
Nsehniitooh Mbah, Prejesh Philips, Michael J Voor, Robert C G Martin
BACKGROUND: The optimal use of esophageal stents for malignant and benign esophageal strictures continues to be plagued with variability in pain tolerance, migration rates, and reflux-related symptoms. The aim of this study was to evaluate the differences in radial force exhibited by a variety of esophageal stents with respect to the patient's esophageal stricture. METHODS: Radial force testing was performed on eight stents manufactured by four different companies using a hydraulic press and a 5000 N force gage...
April 25, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28444283/navigating-transitions-and-charting-new-paths
#8
Philip A Pizzo
No abstract text is available yet for this article.
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28444219/dna-methylation-of-a-novel-pak4-locus-influences-ototoxicity-susceptibility-following-cisplatin-and-radiation-therapy-for-pediatric-embryonal-tumors
#9
Austin L Brown, Kayla L Foster, Philip J Lupo, Erin C Peckham-Gregory, Jeffrey C Murray, M Fatih Okcu, Ching C Lau, Surya P Rednam, Murali Chintagumpala, Michael E Scheurer
Background: Ototoxicity is a common adverse side effect of platinum chemotherapy and cranial radiation therapy; however, individual susceptibility is highly variable. Therefore, the objective of this study was to conduct an epigenome-wide association study to identify differentially methylated CpG sites associated with ototoxicity susceptibility among cisplatin-treated pediatric patients with embryonal tumors. Methods: Samples were collected for a discovery (n=62) and a replication cohort (n=18) of medulloblastoma and primitive neuroectodermal tumor patients...
April 24, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28444204/murine-models-of-sepsis-and-trauma-can-we-bridge-the-gap
#10
Julie A Stortz, Steven L Raymond, Juan C Mira, Lyle L Moldawer, Alicia M Mohr, Philip A Efron
Sepsis and trauma are both leading causes of death in the United States and represent major public health challenges. Murine models have largely been used in sepsis and trauma research to better understand the pathophysiological changes that occur after an insult and to develop potential life-saving therapeutic agents. Mice are favorable subjects for this type of research given the variety of readily available strains including inbred, outbred, and transgenic strains. In addition, they are relatively easy to maintain and have a high fecundity...
April 21, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28443886/supramolecular-chemistry-anniversary
#11
EDITORIAL
David B Amabilino, Philip A Gale
No abstract text is available yet for this article.
April 26, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28443841/automatic-concentration-and-reformulation-of-pet-tracers-via-microfluidic-membrane-distillation
#12
Philip H Chao, Jeffery Collins, Joseph P Argus, Wei-Yu Tseng, Jason T Lee, R Michael van Dam
Short-lived radiolabeled tracers for positron emission tomography (PET) must be rapidly synthesized, purified, and formulated into injectable solution just prior to imaging. Current radiosynthesizers are generally designed for clinical use, and the HPLC purification and SPE formulation processes often result in a final volume that is too large for preclinical and emerging in vitro applications. Conventional technologies and techniques for reducing this volume tend to be slow, resulting in radioactive decay of the product, and often require manual handling of the radioactive materials...
April 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28443837/real-time-plasmonic-qpcr-how-fast-is-ultra-fast-30-cycles-in-54-seconds
#13
Philip J R Roche, Mohamed Najih, Seung S Lee, Lenore K Beitel, Matthew L Carnevale, Miltiadis Paliouras, Andrew G Kirk, Mark A Trifiro
Polymerase Chain Reaction (PCR) is a critical tool for biological research investigators but recently it also has been making a significant impact in clinical, veterinary and agricultural applications. Plasmonic PCR, which employs the very efficient heat transfer of optically irradiated metallic nanoparticles, is a simple and powerful methodology to drive PCR reactions. The scalability of next generation plasmonic PCR technology will introduce various forms of PCR applications ranging from small footprint portable point of care diagnostic devices to large footprint central laboratory multiplexing devices...
April 26, 2017: Analyst
https://www.readbyqxmd.com/read/28442796/resonant-raman-scattering-based-approaches-for-the-quantitative-assessment-of-nanometric-znmgo-layers-in-high-efficiency-chalcogenide-solar-cells
#14
Maxim Guc, Dimitrios Hariskos, Lorenzo Calvo-Barrio, Philip Jackson, Florian Oliva, Paul Pistor, Alejandro Perez-Rodriguez, Victor Izquierdo-Roca
This work reports a detailed resonant Raman scattering analysis of ZnMgO solid solution nanometric layers that are being developed for high efficiency chalcogenide solar cells. This includes layers with thicknesses below 100 nm and compositions corresponding to Zn/(Zn + Mg) content rations in the range between 0% and 30%. The vibrational characterization of the layers grown with different compositions and thicknesses has allowed deepening in the knowledge of the sensitivity of the different Raman spectral features on the characteristics of the layers, corroborating the viability of resonant Raman scattering based techniques for their non-destructive quantitative assessment...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442712/cardioprotective-effects-of-cu-ii-atsm-in-human-vascular-smooth-muscle-cells-and-cardiomyocytes-mediated-by-nrf2-and-dj-1
#15
Salil Srivastava, Philip J Blower, Aisah A Aubdool, Robert C Hider, Giovanni E Mann, Richard C Siow
Cu((II))ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu((II))ATSM, yet there are no reports that it confers cardioprotection. We demonstrate that Cu((II))ATSM activates the redox-sensitive transcription factor Nrf2 in human coronary artery smooth muscle cells (HCASMC) and cardiac myocytes (HCM), leading to upregulation of antioxidant defense enzymes. Oral delivery of Cu((II))ATSM in mice induced expression of the Nrf2-regulated enzymes in the heart and aorta...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28442271/evaluation-of-the-xpert-hcv-viral-load-point-of-care-assay-from-venepuncture-collected-and-finger-stick-capillary-whole-blood-samples-a-cohort-study
#16
Jason Grebely, Francois M J Lamoury, Behzad Hajarizadeh, Yasmin Mowat, Alison D Marshall, Sahar Bajis, Philippa Marks, Janaki Amin, Julie Smith, Michael Edwards, Carla Gorton, Nadine Ezard, David Persing, Marika Kleman, Philip Cunningham, Beth Catlett, Gregory J Dore, Tanya L Applegate
BACKGROUND: Point-of-care hepatitis C virus (HCV) RNA testing offers an advantage over antibody testing (which only indicates previous exposure), enabling diagnosis of active infection in a single visit. In this study, we evaluated the performance of the Xpert HCV Viral Load assay with venepuncture and finger-stick capillary whole-blood samples. METHODS: Plasma and finger-stick capillary whole-blood samples were collected from participants in an observational cohort enrolled at five sites in Australia (three drug and alcohol clinics, one homelessness service, and one needle and syringe programme)...
April 21, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28442236/red-blood-cell-membrane-omega-3-fatty-acid-levels-and-physical-performance-cross-sectional-data-from-the-mapt-study
#17
Bertrand Fougère, Philipe de Souto Barreto, Sabine Goisser, Gaëlle Soriano, Sophie Guyonnet, Sandrine Andrieu, Bruno Vellas
BACKGROUND & AIMS: Studies have shown that omega-3 polyunsaturated fatty acids (PUFAs) are associated with brain, cardiovascular and immune function, as well as physical performance and bone health in older adults. So far, few studies have highlighted the associations between PUFA status and performance-based tests of physical function. To study the associations between the omega-3 index (red blood cell (RBC) membrane content of omega-3 PUFAs, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and physical performance measured with the Short Physical Performance Battery (SPPB) in a sample of community-dwelling older adults...
April 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28442194/a-child-abuse-research-network-now-what
#18
Daniel M Lindberg, Philip V Scribano
As foundational work in preparation for a sustainable, multi-center network devoted to child abuse medical research, we recently used a combination of survey and modified Delphi methodologies to determine research priorities for future multi-center studies. Avoiding missed diagnoses, and improving selected/indicated prevention were the topics rated most highly in terms of research priority. Several constructive commentaries in this issue identify the key challenges which must be overcome to ensure a successful network...
April 22, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28442103/man-with-painless-oral-lesions
#19
Alexander Philip, Amanda W Smith, Josh Greenstein, Barry Hahn
No abstract text is available yet for this article.
May 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28441958/metformin-to-augment-strength-training-effective-response-in-seniors-masters-study-protocol-for-a-randomized-controlled-trial
#20
Doug E Long, Bailey D Peck, Jenny L Martz, S Craig Tuggle, Heather M Bush, Gerald McGwin, Philip A Kern, Marcas M Bamman, Charlotte A Peterson
BACKGROUND: Muscle mass and strength are strong determinants of a person's quality of life and functional independence with advancing age. While resistance training is the most effective intervention to combat age-associated muscle atrophy (sarcopenia), the ability of older adults to increase muscle mass and strength in response to training is blunted and highly variable. Thus, finding novel ways to complement resistance training to improve muscle response and ultimately quality of life among older individuals is critical...
April 26, 2017: Trials
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