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https://www.readbyqxmd.com/read/29880281/roundtable-discussion-dietary-fats-in-prevention-of-atherosclerotic-cardiovascular-disease
#1
REVIEW
Tracy Severson, Penny M Kris-Etherton, Jennifer G Robinson, John R Guyton
This roundtable discussion on dietary fats was inspired by a recent Presidential Advisory from the American Heart Association giving recommendations about dietary fats for prevention of atherosclerotic cardiovascular disease. The Advisory clarifies a long-held position that saturated fat should be reduced in the American diet. New studies and meta-analyses have questioned the adverse role of saturated fat. The Advisory adds a crucial clarification based primarily on 4 randomized controlled diet trials, each conducted over 4 to 8 years during the 1960s extending to the 1970s...
May 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29805927/long-term-quality-of-life-in-survivors-of-brain-metastases-a-roller-coaster-of-perspective
#2
Naveen Kumar Reddy, Franklin C Brown, Miklos C Fogarasi, James B Yu, Judith Hess, Veronica S Chiang
Longevity in cancer patients with brain metastases is increasingly being observed. This raises discussions about how best to maintain a good quality of life for these patients. Recent data suggest that post-treatment quality of life (QoL) can be maintained using new treatment options, but little data exist regarding the QoL in long-term survivors. This study of 19 patients surviving greater than two years from the initial treatment of brain metastases suggests that long-term QoL can be better than at the start of treatment and perhaps even better than normal, especially between three and five years post-treatment...
March 22, 2018: Curēus
https://www.readbyqxmd.com/read/29758944/the-conundrum-of-gsk3-inhibitors-is-it-the-dawn-of-a-new-beginning
#3
Ratan V Bhat, Ulf Andersson, Shalini Andersson, Laurent Knerr, Udo Bauer, Anna Sundgren Andersson
Spanning over three decades of extensive drug discovery research, the efforts to develop a potent and selective GSK3 inhibitor as a therapeutic for the treatment of type 2 diabetes, Alzheimer's disease (AD), bipolar disorders and cancer have been futile. Since its initial discovery in 1980 and subsequent decades of research, one cannot underscore the importance of the target and the promise of a game changing disease modifier. Several pharmaceutical companies, biotech companies, and academic institutions raged in a quest to unravel the biology and discover potent and selective GSK3 inhibitors, some of which went through clinical trials...
May 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29701424/perioperative-family-centered-care-nursing-interventions-that-support-child-and-family-s-emotional-management
#4
Dario Antunes, Paula Diogo
INTRODUCTION: Hospitalization is a negative tonality experience for both child and family, being fear and anxiety their emotional mirror. Concerning the surgical experience, the environment, invasiveness, fear of pain, of not waking up from anaesthesia and parental separation are both causes and enhancers of child and family perioperative distress. A study concerning parent's emotional experience of child's submitted to cardiac surgery, refer guilt for their son's cardiopathy, a roller coaster of emotions, impotence and being seated on pins and needles while waiting during the surgery...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29649509/cybersickness-related-changes-in-brain-hemodynamics-a-pilot-study-comparing-transcranial-doppler-and-near-infrared-spectroscopy-assessments-during-a-virtual-ride-on-a-roller-coaster
#5
Alireza Mazloumi Gavgani, Rachel H X Wong, Peter R C Howe, Deborah M Hodgson, Frederick R Walker, Eugene Nalivaiko
Our aim was to assess cerebral blood flow changes during cybersickness. Transcranial Doppler (TCD) ultrasound and near infrared spectroscopy (NIRS) were used separately in two independent experiments. In both studies, a 15-min virtual roller coaster ride was used as a provocative visual stimulus. Subjective nausea ratings were obtained at 1 min intervals. The TCD study was performed in 14 healthy subjects (8 males and 6 females); in this study we also measured heart rate and arterial pressure. In a separate study a 52-channel NIRS device (Hitachi ETG-4000) was used to monitor activated brain regions by measuring oxy-hemoglobin (HbO2) concentration in 9 healthy subjects (4 male, 5 females)...
July 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29524202/a-case-report-of-conservative-management-for-a-roller-coaster-related-vitreous-haemorrhage
#6
Alexander James Brent, Abdul R El-Khayat, Shamfa A M Peart, Somnath Banerjee
The purpose of this report is to describe the case and management of an unexplained vitreous haemorrhage that occurred after repeated roller-coaster riding. The authors inadvertently demonstrate the value of observation over immediate surgery in certain situations and review the literature on vitreoretinal and other ocular complications after roller-coaster riding. A 26-year-old male presented 12 h after riding high-velocity roller-coasters with a left vitreous haemorrhage. A hazy view of the retina and B-scan revealed a bullous area of superior-temporal retinal lifting...
March 9, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29486480/improving-family-functioning-to-hopefully-improve-treatment-efficacy-of-borderline-personality-disorder-an-opportunity-not-to-dismiss
#7
Andrea Fossati, Antonella Somma
People having intimate relationships with persons suffering from borderline personality disorder (BPD) - for instance, members of their family - are likely to be involved in stormy, roller coaster relationships. Thus, they may feel overwhelmed by extreme, unpredictable feelings and situations, even when they do not suffer from any mental disorder or have no problems with mentalization. As a consequence of living with a BPD relative, family members often experience an emotional and financial burden, and may blame themselves for their relative's illness or for not being able to do more to help...
February 27, 2018: Psychopathology
https://www.readbyqxmd.com/read/29426906/alps-to-apennines-zircon-roller-coaster-along-the-adria-microplate-margin
#8
J Jacobs, G Paoli, S Rocchi, A K Ksienzyk, H Sirevaag, M A Elburg
We have traced the particle path of high-pressure metasedimentary rocks on Elba Island, Northern Apennines, with the help of a U-Pb-Hf detrital zircon study. One quarter of the analysed zircons are surprisingly young, 41-30 Ma, with a main age peak at ca. 32 Ma, indicating an unexpected early Oligocene maximum deposition age. These Oligocene ages with negative εHf indicate a volcanic source region in the central-southern Alps. Though young by geological means, these zircons record an extraordinary geodynamic history...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29284273/a-double-whammy-new-baccalaureate-registered-nurses-transitions-into-rural-acute-care
#9
Jean Smith, Virginia Vandall-Walker
INTRODUCTION: Transitioning into the Canadian rural acute care environment can be challenging for new RNs, and so retention is of concern. Currently, few seasoned registered nurses (RNs) are available to support new RNs during transition because (a) the Canadian RN workforce countrywide is aging and significant numbers are retiring, and (b) the number of Canadian RNs working rurally has plummeted in the past 10 years. Investigations into the phenomenon of new RNs\' transitions into the workforce have been conducted, but little is known about this phenomenon as it relates to Canadian rural acute care hospitals...
December 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/29276259/formal-leadership-thrilling-and-scary-like-a-roller-coaster-ride
#10
EDITORIAL
Sara J White
No abstract text is available yet for this article.
June 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28758968/middle-cerebral-artery-stroke-as-amusement-park-injury-case-report-and-review-of-the-literature
#11
Abby Baumgartle, Laura Wolfe, Vinay Puri, Karen Moeller, Salvatore Bertolone, Ashok Raj
Strokes as amusement park injuries are rare, but have been reported in the literature. Only about 20 cases of cerebrovascular accidents after amusement park visits have been described. We report a healthy 12-year-old boy who presented with facial droop, slurred speech, and inability to use his right arm after riding roller coasters at a local amusement park. He was evaluated and found to have a left middle cerebral artery (MCA) infarction. The patient was treated with anticoagulants and has recovered with no major residual symptoms...
July 31, 2017: Children
https://www.readbyqxmd.com/read/28683585/pilot-findings-of-brain-displacements-and-deformations-during-roller-coaster-rides
#12
Calvin Kuo, Lyndia C Wu, Patrick P Ye, Kaveh Laksari, David B Camarillo, Ellen Kuhl
With 300,000,000 riders annually, roller coasters are a popular recreational activity. Although the number of roller coaster injuries is relatively low, the precise effect of roller coaster rides on our brains remains unknown. Here we present the quantitative characterization of brain displacements and deformations during roller coaster rides. For two healthy adult male subjects, we recorded head accelerations during three representative rides, and, for comparison, during running and soccer headers. From the recordings, we simulated brain displacements and deformations using rigid body dynamics and finite element analyses...
November 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28612649/a-brain-on-a-roller-coaster-can-the-dopamine-reward-system-act-as-a-protagonist-to-subdue-the-ups-and-downs-of-bipolar-disorder
#13
Shokouh Arjmand, Mina Behzadi, Gary J Stephens, Sara Ezzatabadipour, Rostam Seifaddini, Shahrad Arjmand, Mohammad Shabani
One of the most interesting but tenebrous parts of the bipolar disorder (BD) story is the switch between (hypo)mania and depression, which can give bipolar patients a thrilling, but somewhat perilous, 'ride'. Numerous studies have pointed out that there are some recognizable differences (either state-dependent or state-independent) in several brain regions of people with BD, including components of the brain's reward system. Understanding the underpinning mechanisms of high and low mood statuses in BD has potential, not only for the development of highly specific and selective pharmaceutical agents, but also for better treatment approaches and psychological interventions to manage BD and, thus, give patients a safer ride...
June 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28556853/evaluation-of-renal-calculi-passage-while-riding-a-roller-coaster
#14
LETTER
Michael R Bailey
No abstract text is available yet for this article.
June 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28298437/riding-the-metalloproteinase-roller-coaster
#15
Gillian Murphy
To many of us in the field, working on<u>m</u>atrix<u>m</u>etalloproteinases (MMPs) has felt like riding a roller coaster, traveling through times of both excitement and despair. I was fortunate to join the ride when it was a mere carousel of three activities thought to target the proteins that comprise the extracellular matrix (ECM). New technologies brought the thrills of discovery as we uncovered specific proteinase genes and defined specialized activities in different cellular processes...
May 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28245669/the-nearly-invisible-intraneural-cyst-a-new-and-emerging-part-of-the-spectrum
#16
Thomas J Wilson, Marie-Noëlle Hébert-Blouin, Naveen S Murthy, Joaquín J García, Kimberly K Amrami, Robert J Spinner
OBJECTIVE The authors have observed that a subset of patients referred for evaluation of peroneal neuropathy with "negative" findings on MRI of the knee have subtle evidence of a peroneal intraneural ganglion cyst on subsequent closer inspection. The objective of this study was to introduce the nearly invisible peroneal intraneural ganglion cyst and provide illustrative cases. The authors further wanted to identify clues to the presence of a nearly invisible cyst. METHODS Illustrative cases demonstrating nearly invisible peroneal intraneural ganglion cysts were retrospectively reviewed and are presented...
March 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28165318/an-evaluation-approach-for-the-performance-of-dosing-regimens-in-attention-deficit-hyperactivity-disorder-treatment
#17
Guillaume Bonnefois, Philippe Robaey, Olivier Barrière, Jun Li, Fahima Nekka
OBJECTIVE: Stimulant medications, with methylphenidate as the main agent, are the most prescribed for the treatment of attention-deficit/hyperactivity disorder. Nevertheless, real challenges still remain for clinicians concerned with adaptation of the therapeutic regimens, in terms of doses and timing, to children's daily activities. The aim of this study was to optimize short-acting methylphenidate regimens according to specific children's needs by evaluating the performance of a particular regimen through a web-based application...
May 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28076574/macular-hemorrhage-after-roller-coaster-riding-in-a-single-eyed-patient-with-congenital-glaucoma
#18
Dilek Guven, Zeynep Acar, Mehmet Demir, Yekta Sendul, Atilla Gokce Demir, Erdem Ergen
A 21-year-old female presented with a 4-day history of decreased vision in her only functional eye (right eye, OD). She had a history of multiple ocular surgeries in both eyes because of congenital glaucoma and had lost light perception in her left eye several years prior. Ophthalmological examination revealed 0.15 Snellen visual acuity, and fundoscopy revealed nearly total cupping and pallor of the optic disc and multiple retinal hemorrhagic foci in the macula in OD. Lesions spontaneously resolved over a few months...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28006955/speechless-after-a-roller-coaster-ride
#19
Valerie Whitcomb, Nirupama Kannikeswaran, Nirmala Bhaya, Deniz Altinok, Lalitha Sivaswamy
No abstract text is available yet for this article.
February 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/27669068/validation-of-a-functional-pyelocalyceal-renal-model-for-the-evaluation-of-renal-calculi-passage-while-riding-a-roller-coaster
#20
Marc A Mitchell, David D Wartinger
CONTEXT: The identification and evaluation of activities capable of dislodging calyceal renal calculi require a patient surrogate or validated functional pyelocalyceal renal model. OBJECTIVE: To evaluate roller coaster facilitation of calyceal renal calculi passage using a functional pyelocalyceal renal model. METHODS: A previously described adult ureteroscopy and renoscopy simulator (Ideal Anatomic) was modified and remolded to function as a patient surrogate...
October 1, 2016: Journal of the American Osteopathic Association
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