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roller coaster

Gillian Murphy
To many of us in the field, working on Matrix Metalloproteinases (MMPs) has felt like riding a roller coaster, traveling through times of both excitement and despair. I was fortunate to join the ride when it was a mere carousel of three activities thought to target the proteins that comprise the extracellular matrix (ECM). New technologies brought the thrills of discovery, as we uncovered specific proteinase genes and defined specialised activities in different cellular processes. The MMPs and the sister families of 'A Disintegrin And Metalloproteinase' (ADAMs), ADAMs with ThromboSpondin domains (ADAM-TS) and Astacins are now recognised as key signalling 'scissors' that drive rapid changes in a plethora of cellular pathways...
March 15, 2017: Journal of Biological Chemistry
Thomas J Wilson, Marie-Noëlle Hébert-Blouin, Naveen S Murthy, Joaquín J García, Kimberly K Amrami, Robert J Spinner
OBJECTIVE The authors have observed that a subset of patients referred for evaluation of peroneal neuropathy with "negative" findings on MRI of the knee have subtle evidence of a peroneal intraneural ganglion cyst on subsequent closer inspection. The objective of this study was to introduce the nearly invisible peroneal intraneural ganglion cyst and provide illustrative cases. The authors further wanted to identify clues to the presence of a nearly invisible cyst. METHODS Illustrative cases demonstrating nearly invisible peroneal intraneural ganglion cysts were retrospectively reviewed and are presented...
March 2017: Neurosurgical Focus
Guillaume Bonnefois, Philippe Robaey, Olivier Barrière, Jun Li, Fahima Nekka
OBJECTIVE: Stimulant medications, with methylphenidate as the main agent, are the most prescribed for the treatment of attention-deficit/hyperactivity disorder. Nevertheless, real challenges still remain for clinicians concerned with adaptation of the therapeutic regimens, in terms of doses and timing, to children's daily activities. The aim of this study was to optimize short-acting methylphenidate regimens according to specific children's needs by evaluating the performance of a particular regimen through a web-based application...
February 6, 2017: Journal of Child and Adolescent Psychopharmacology
Dilek Guven, Zeynep Acar, Mehmet Demir, Yekta Sendul, Atilla Gokce Demir, Erdem Ergen
A 21-year-old female presented with a 4-day history of decreased vision in her only functional eye (right eye, OD). She had a history of multiple ocular surgeries in both eyes because of congenital glaucoma and had lost light perception in her left eye several years prior. Ophthalmological examination revealed 0.15 Snellen visual acuity, and fundoscopy revealed nearly total cupping and pallor of the optic disc and multiple retinal hemorrhagic foci in the macula in OD. Lesions spontaneously resolved over a few months...
November 2016: Arquivos Brasileiros de Oftalmologia
Valerie Whitcomb, Nirupama Kannikeswaran, Nirmala Bhaya, Deniz Altinok, Lalitha Sivaswamy
No abstract text is available yet for this article.
February 2017: Clinical Pediatrics
Marc A Mitchell, David D Wartinger
CONTEXT: The identification and evaluation of activities capable of dislodging calyceal renal calculi require a patient surrogate or validated functional pyelocalyceal renal model. OBJECTIVE: To evaluate roller coaster facilitation of calyceal renal calculi passage using a functional pyelocalyceal renal model. METHODS: A previously described adult ureteroscopy and renoscopy simulator (Ideal Anatomic) was modified and remolded to function as a patient surrogate...
October 1, 2016: Journal of the American Osteopathic Association
Guido E Pieles, Victoria Husk, Teresa Blackwell, Deirdre Wilson, Simon M Collin, Craig A Williams, A Graham Stuart
Theme park operators and medical professionals advise children with heart conditions against using rollercoaster rides, but these recommendations are not evidence-based. The underlying assumption is that the combination of adrenergic stimulation through stress and acceleration might trigger arrhythmias in susceptible individuals. We conducted a cross-sectional observational study to assess heart rate and rhythm in healthy children during commercial rollercoaster rides. Twenty healthy children (9 male) aged 11-15 (mean 13...
January 2017: Pediatric Cardiology
Todd Linden
The Rural Health Care Leadership Conference offers the chance for executives and board members to network and gain insights from each other and expert presenters. And there's a bonus: It's in Phoenix in February.
January 2016: Trustee: the Journal for Hospital Governing Boards
Ryan Eid, Ashok Raj, Darren Farber, Vinay Puri, Salvatore Bertolone
Spinal cord infarction (SCI) is extremely rare in children, and only 2 other reports have described the occurrence of SCI in patients with hemoglobin SC disease (HbSC). Amusement park accidents are serious injuries. Patients with preexisting conditions, such as hypertension, cardiac disease, and recent back or neck injuries, may be at an increased risk. We report the case of a 12-year-old girl with HbSC with a past history of only 2 admissions for pain crises, who presented to the emergency department with symptoms of SCI after riding a roller coaster...
September 2016: Pediatrics
Rebecca Fischbein, James Meeker, Julia R Saling, Michelle Chyatte, Lauren Nicholas
BACKGROUND: Twin-to-twin transfusion syndrome (TTTS) affects 10-20 % of monochorionic diamniotic (MCDA) births and accounts for 50 % of fetal loss in MCDA pregnancies. This exploratory qualitative study identified shared experiences, including potential emotional and psychosocial impacts, of this serious disease. METHODS: Forty-five publicly accessible, online stories posted by families who experienced TTTS were analyzed using grounded theory. RESULTS: Shared TTTS experiences included a common trajectory: early pregnancy experiences, diagnostic experiences, making decisions, interventions and variable outcomes...
2016: BMC Pregnancy and Childbirth
Changhee Kim, Soowook Kim
This study assesses the operation efficiency of theme park attractions using the data envelopment analysis, utilizing actual data on 15 attractions at Samsung Everland located in Yongin-si, Republic of Korea. In particular, this study identifies crowding and waiting time as one of the main causes of visitor's satisfaction, and analyzes the efficiency of individual attractions in terms of waiting time. The installation area, installation cost, and annual repair cost are set as input factors and the number of annual users and customer satisfaction as output factors...
2016: SpringerPlus
Henri Weimerskirch, Charles Bishop, Tiphaine Jeanniard-du-Dot, Aurélien Prudor, Gottfried Sachs
Understanding how animals respond to atmospheric conditions across space is critical for understanding the evolution of flight strategies and long-distance migrations. We studied the three-dimensional movements and energetics of great frigate birds (Fregata minor) and showed that they can stay aloft for months during transoceanic flights. To do this, birds track the edge of the doldrums to take advantage of favorable winds and strong convection. Locally, they use a roller-coaster flight, relying on thermals and wind to soar within a 50- to 600-meter altitude band under cumulus clouds and then glide over kilometers at low energy costs...
July 1, 2016: Science
Dawei Li, Nancy L Zucker, Philip A Kragel, Virginia E Covington, Kevin S LaBar
Adolescence is hypothesized to be a critical period for the maturation of self-regulatory capacities, including those that depend on interoceptive sensitivity, but the neural basis of interoceptive regulation in adolescence is unknown. We used functional magnetic resonance imaging and psychophysiology to study interoceptive regulation in healthy adolescent females. Participants regulated their gut activities in response to a virtual roller coaster by deep breathing aided by visually monitoring their online electrogastrogram (EGG) activity through a virtual thermometer (i...
June 19, 2016: Developmental Science
Mark Rumbak
No abstract text is available yet for this article.
June 2016: American Journal of the Medical Sciences
(no author information available yet)
No abstract text is available yet for this article.
March 2016: Australian Nursing & Midwifery Journal
Britt Laugesen, Marlene Briciet Lauritsen, Rikke Jørgensen, Erik Elgaard Sørensen, Philippa Rasmussen, Mette Grønkjær
AIM: This systematic review is aimed to identify and synthesize the best available evidence on parenting experiences of living with a child with attention-deficit hyperactivity disorder, including their experiences of healthcare and other services. METHODS: A meta-synthesis was conducted following the Joanna Briggs Institute (JBI) guidelines. Qualitative research articles were considered for inclusion in the review and the meta-aggregative approach to synthesizing qualitative evidence from JBI was followed...
December 2016: International Journal of Evidence-based Healthcare
Florian Kronenberg
Bowe et al. report an association between low high-density lipoprotein cholesterol concentrations and various incident chronic kidney disease end points in a cohort of almost 2 million US veterans followed for 9 years. These impressive data should be a starting point for further investigations including genetic epidemiologic investigations as well as post hoc analyses of interventional trials that target high-density lipoprotein cholesterol and, finally, studies that focus on the functionality of high-density lipoprotein particles...
April 2016: Kidney International
Jenna A LoGiudice, Cheryl T Beck
INTRODUCTION: In the United States, one in every 5 women will experience sexual violence. Survivors are at risk for difficult pregnancies, substance abuse, stress, fear, and preterm births. A history of sexual abuse can impact several aspects of a woman's childbirth, thereby affecting her long-term physical and emotional well-being. The adverse pregnancy outcomes, combined with the prevalence of sexual abuse, underscore the need for research to understand survivors' experiences. METHODS: This study's purpose was to understand the lived experience of pregnancy, labor, and birth from survivors...
July 2016: Journal of Midwifery & Women's Health
V Sri Nagesh
The ultimate dream of every young student stepping into the hallowed portals of a medical college is to achieve the holy grail of medical education, a DM seat. However, the real battle begins only after the DM seat is won. The residency is a veritable roller coaster ride all through the three years, with the student alternating between exhilaration and despondency, wisdom and foolishness, hope and despair and ecstasy and agony. The long working hours, logistic difficulties, interpersonal conflicts and resource limitations are the anvils on which the callow postgraduates are beaten into shape, to bring to fore, their inner steel...
January 2016: Indian Journal of Endocrinology and Metabolism
Britt Laugesen, Mette Groenkjaer
BACKGROUND: Attention deficit hyperactivity disorder is the most prevalent mental disorder among children and adolescents worldwide. Parenting a child with attention deficit hyperactivity disorder is challenging and parents find it difficult to raise the child and struggle to get professional support. Research has shown how living with a child with Attention Deficit Hyperactivity Disorder influences the families' daily life. This includes how the parents manage to maintain a bearable family life, supportive or not supportive factors as well as parents' experiences of collaboration with professionals in diverse settings...
November 2015: JBI Database of Systematic Reviews and Implementation Reports
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