Sorin Marian Mârza, Adela Maria Dăescu, Robert Cristian Purdoiu, Mădălina Dragomir, Mariana Tătaru, Iulia Melega, Andras-Laszlo Nagy, Adrian Gal, Flaviu Tăbăran, Sidonia Bogdan, Mirela Moldovan, Emoke Pall, Camelia Munteanu, Klara Magyari, Ionel Papuc
Rosmarinic acid is a well-known natural antioxidant and anti-inflammatory compound, and it is one of the polyphenolic compounds found in comfrey plants. Comfrey root also contains allantoin, which helps with new skin regeneration. This study aimed to investigate the healing and skin regeneration process of skin wounds in Wistar rats using creams based on comfrey extract and to correlate the results with active compounds in the extract. The obtained results showed that comfrey root is rich in bioactive compounds, including allantoin, salvianolic acid, and rosmarinic acid, which are known for their great free radical scavenging activity, and the high antioxidant activity of the extract may be mainly due to these compounds...
March 7, 2024: International Journal of Molecular Sciences