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https://www.readbyqxmd.com/read/16812978/clinical-impact-of-cachexia-on-survival-and-outcome-of-cancer-patients
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C Dimitriu, M E Martignoni, Jeaninne Bachmann, B Fröhlich, G Tintărescu, T Buliga, I Lică, G Constantinescu, M Beuran, H Friess
Approximately one half of all cancer patients experience a complex metabolic status involving progressive exhaustion of adipose and skeletal muscle tissue. This condition, known as cachexia, is responsible for more than 20% of the overall deaths in cancer patients. Although its main mechanisms remain unknown, several hypotheses have been proposed. One of the pathogenic mechanisms involves leptin and hypothalamic neuropeptide-containing pathways. Orexigenic and anorexigenic neuropeptides are down-regulated respectively upregulated as a result of cancer...
2005: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
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