keyword
https://read.qxmd.com/read/38534366/steroidogenesis-upregulation-through-mitochondria-associated-endoplasmic-reticulum-membranes-and-mitochondrial-dynamics-in-rat-testes-the-role-of-d-aspartate
#1
JOURNAL ARTICLE
Debora Latino, Massimo Venditti, Sara Falvo, Giulia Grillo, Alessandra Santillo, Imed Messaoudi, Mariem Ben Rhouma, Sergio Minucci, Gabriella Chieffi Baccari, Maria Maddalena Di Fiore
Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) mediate the communication between the Endoplasmic Reticulum (ER) and the mitochondria, playing a fundamental role in steroidogenesis. This study aimed to understand how D-aspartate (D-Asp), a well-known stimulator of testosterone biosynthesis and spermatogenesis, affects the mechanism of steroidogenesis in rat testes. Our results suggested that D-Asp exerts this function through MAMs, affecting lipid trafficking, calcium signaling, ER stress, and mitochondrial dynamics...
March 16, 2024: Cells
https://read.qxmd.com/read/38511146/-in-vitro-and-in-vivo-studies-on-the-effect-of-a-mitochondrial-fusion-promoter-on-leydig-cell-integrity-and-function
#2
JOURNAL ARTICLE
Samuel Garza, Chantal Sottas, Hovhannes J Gukasyan, Vassilios Papadopoulos
Background: The interstitial testicular Leydig cells are responsible for the production of testosterone, which functionally deteriorate with normal aging. Decreased expression of mitochondrial steroidogenic interactome proteins and diminished mitochondrial function in aging Leydig cells suggest that mitochondrial dynamics play a role in maintaining adequate levels of testosterone. Optic atrophy 1 (OPA1) protein regulates mitochondrial dynamics and cristae formation in many cell types. Previous studies showed that increasing OPA1 expression in dysfunctional Leydig cells restored mitochondrial function and recovered androgen production to levels found in healthy Leydig cells...
2024: Frontiers in toxicology
https://read.qxmd.com/read/38503156/rhodiola-crenulata-alleviates-hypobaric-hypoxia-induced-brain-injury-by-maintaining-bbb-integrity-and-balancing-energy-metabolism-dysfunction
#3
JOURNAL ARTICLE
Ya Hou, Fuhan Fan, Na Xie, Yi Zhang, Xiaobo Wang, Xianli Meng
BACKGROUND/PURPOSE: Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (R. crenulate), a famous and characteristic Tibetan medicine, has been demonstrated to exert an outstanding brain protection role in the treatment of high-altitude hypoxia disease. However, the metabolic effects of R. crenulate on high-altitude hypoxic brain injury (HHBI) are still incompletely understood. Herein, the anti-hypoxic effect and associated mechanisms of R. crenulate were explored through both in vivo and in vitro experiments...
March 11, 2024: Phytomedicine
https://read.qxmd.com/read/38496899/imbalance-of-mitochondrial-fusion-in-peripheral-blood-mononuclear-cells-is-associated-with-liver-fibrosis-in-patients-with-metabolic-dysfunction-associated-steatohepatitis
#4
JOURNAL ARTICLE
Thanaput Kunlayawutipong, Nattayaporn Apaijai, Kanokkan Tepmalai, Sarawut Kongkarnka, Apinya Leerapun, Kanokporn Pinyopornpanish, Atiwat Soontornpun, Siriporn C Chattipakorn, Nipon Chattipakorn, Kanokwan Pinyopornpanish
Mitochondrial dysfunction and inflammation contribute to the pathophysiology of metabolic dysfunction-associated steatohepatitis (MASH). This study aims to evaluate the potential association between mitochondrial dynamics and cell death markers from peripheral blood mononuclear cells (PBMCs) and the presence of MASH with significant liver fibrosis among metabolic dysfunction-associated steatotic liver disease (MASLD) patients. Consecutive patients undergoing bariatric surgery from January to December 2022 were included...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38474152/downregulation-of-mitochondrial-fusion-protein-expression-affords-protection-from-canonical-necroptosis-in-h9c2-cardiomyoblasts
#5
JOURNAL ARTICLE
Yuki Toda, Sang-Bing Ong, Toshiyuki Yano, Atsushi Kuno, Hidemichi Kouzu, Tatsuya Sato, Wataru Ohwada, Yuki Tatekoshi, Toshifumi Ogawa, Masaki Shimizu, Masaya Tanno, Masato Furuhashi
Necroptosis, a form of necrosis, and alterations in mitochondrial dynamics, a coordinated process of mitochondrial fission and fusion, have been implicated in the pathogenesis of cardiovascular diseases. This study aimed to determine the role of mitochondrial morphology in canonical necroptosis induced by a combination of TNFα and zVAD (TNF/zVAD) in H9c2 cells, rat cardiomyoblasts. Time-course analyses of mitochondrial morphology showed that mitochondria were initially shortened after the addition of TNF/zVAD and then their length was restored, and the proportion of cells with elongated mitochondria at 12 h was larger in TNF/zVAD-treated cells than in non-treated cells (16...
March 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38469619/loss-of-foxo1-activates-an-alternate-mechanism-of-mitochondrial-quality-control-for-healthy-adipose-browning
#6
JOURNAL ARTICLE
Limin Shi, Jinying Yang, Zhipeng Tao, Louise Zheng, Tyler F Bui, Ramon L Alonso, Feng Yue, Zhiyong Cheng
Browning of white adipose tissue is hallmarked by increased mitochondrial density and metabolic improvements. However, it remains largely unknown how mitochondrial turnover and quality control are regulated during adipose browning. In the present study, we found that mice lacking adipocyte FoxO1, a transcription factor that regulates autophagy, adopted an alternate mechanism of mitophagy to maintain mitochondrial turnover and quality control during adipose browning. Post-developmental deletion of adipocyte FoxO1 (adO1KO) suppressed Bnip3 but activated Fundc1/Drp1/OPA1 cascade, concurrent with up-regulation of Atg7 and CTSL...
March 20, 2024: Clinical Science (1979-)
https://read.qxmd.com/read/38467926/renal-coloboma-syndrome-dominant-optic-atrophy-with-severe-retinal-atrophy-and-de-novo-digenic-mutations-in-pax2-and-opa1
#7
JOURNAL ARTICLE
Wataru Shimabukuro, Yasutsugu Chinen, Naoya Imanaga, Kumiko Yanagi, Tadashi Kaname, Koichi Nakanishi
Renal coloboma syndrome (RCS) and dominant optic atrophy are mainly caused by heterozygous mutations in PAX2 and OPA1, respectively. We describe a patient with digenic mutations in PAX2 and OPA1. A female infant was born without perinatal abnormalities. Magnetic resonance imaging at 4 months of age showed bilateral microphthalmia and optic nerve hypoplasia. Appropriate body size was present at 2 years of age, and mental development was favorable. Color fundus photography revealed severe retinal atrophy in both eyes...
March 11, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38464287/the-loss-of-opa1-accelerates-intervertebral-disc-degeneration-and-osteoarthritis-in-aged-mice
#8
Makarand Risbud, Vedavathi Madhu, Miriam Hernandez-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige Boneski, Hiromi Sesaki, John Collins
NP cells of the intervertebral disc and articular chondrocytes reside in avascular and hypoxic tissue niches. As a consequence of these environmental constraints the cells are primarily glycolytic in nature and were long thought to have a minimal reliance on mitochondrial function. Recent studies have challenged this long-held view and highlighted the increasingly important role of mitochondria in the physiology of these tissues. However, the foundational understanding of mechanisms governing mitochondrial dynamics and function in these tissues is lacking...
February 20, 2024: Research Square
https://read.qxmd.com/read/38463054/molecular-insights-into-codon-usage-analysis-of-mitochondrial-fission-and-fusion-gene-relevance-to-neurodegenerative-diseases
#9
JOURNAL ARTICLE
Rekha Khandia, Megha Katare Pandey, Rajkumar Garg, Azmat Ali Khan, Igor Baklanov, Amer M Alanazi, Prakash Nepali, Pankaj Gurjar, Om Prakash Choudhary
Mitochondrial dysfunction is the leading cause of neurodegenerative disorders like Alzheimer's disease and Parkinson's disease. Mitochondria is a highly dynamic organelle continuously undergoing the process of fission and fusion for even distribution of components and maintaining proper shape, number, and bioenergetic functionality. A set of genes governs the process of fission and fusion. OPA1, Mfn1 , and Mfn2 govern fusion, while Drp1 , Fis1 , MIEF1 , and MIEF2 genes control fission. Determination of specific molecular patterns of transcripts of these genes revealed the impact of compositional constraints on selecting optimal codons...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38462198/tdcpp-and-tio-2-nps-aggregates-synergistically-induce-sh-sy5y-cell-neurotoxicity-by-excessive-mitochondrial-fission-and-mitophagy-inhibition
#10
JOURNAL ARTICLE
Ling Wang, Binquan Wang, Xiaoyan Zhang, Ziyi Yang, Xing Zhang, Hongyang Gong, Yuanyuan Song, Ke Zhang, Mingkuan Sun
Tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a halogen-containing phosphorus flame retardant, is widely used and has been shown to possess health risks to humans. The sustained release of artificial nanomaterials into the environment increases the toxicological risks of their coexisting pollutants. Nanomaterials may seriously change the environmental behavior and fate of pollutants. In this study, we investigated this combined toxicity and the potential mechanisms of toxicity of TDCPP and titanium dioxide nanoparticles (TiO2 NPs) aggregates on human neuroblastoma SH-SY5Y cells...
March 8, 2024: Environmental Pollution
https://read.qxmd.com/read/38461295/novel-meriolin-derivatives-activate-the-mitochondrial-apoptosis-pathway-in-the-presence-of-antiapoptotic-bcl-2
#11
JOURNAL ARTICLE
Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A Skowron, Marlena Sekeres, Julia Hoppe, Karina S Krings, Tanya R Llewellyn, Christoph Peter, Björn Stork, Nan Qin, Sanil Bhatia, Daniel Nettersheim, Gerhard Fritz, Ana J García-Sáez, Thomas J J Müller, Sebastian Wesselborg
Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) that displayed a strong apoptotic potential in Jurkat leukemia and Ramos lymphoma cells. Meriolin 16 induced apoptosis in rapid kinetics (within 2-3 h) and more potently (IC50 : 50 nM) than the previously described derivatives meriolin 31 and 36 [1]. Exposure of Ramos cells to meriolin 16, 31, or 36 for 5 min was sufficient to trigger severe and irreversible cytotoxicity...
March 9, 2024: Cell Death Discovery
https://read.qxmd.com/read/38459070/activity-dependent-compartmentalization-of-dendritic-mitochondria-morphology-through-local-regulation-of-fusion-fission-balance-in-neurons-in-vivo
#12
JOURNAL ARTICLE
Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Fiona M Russell, D Grahame Hardie, Julien Prudent, Erik Bloss, Attila Losonczy, Franck Polleux, Tommy L Lewis
Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly between the axon and dendrites of a given neuronal subtype, but in CA1 pyramidal neurons (PNs) of the hippocampus, mitochondria within the dendritic arbor also display a remarkable degree of subcellular, layer-specific compartmentalization. In the dendrites of these neurons, mitochondria morphology ranges from highly fused and elongated in the apical tuft, to more fragmented in the apical oblique and basal dendritic compartments, and thus occupy a smaller fraction of dendritic volume than in the apical tuft...
March 8, 2024: Nature Communications
https://read.qxmd.com/read/38456936/clinical-and-genetic-architecture-of-a-large-cohort-with-auditory-neuropathy
#13
JOURNAL ARTICLE
Hongyang Wang, Liping Guan, Xiaonan Wu, Jing Guan, Jin Li, Nan Li, Kaili Wu, Ya Gao, Dan Bing, Jianguo Zhang, Lan Lan, Tao Shi, Danyang Li, Wenjia Wang, Linyi Xie, Fen Xiong, Wei Shi, Lijian Zhao, Dayong Wang, Ye Yin, Qiuju Wang
Auditory neuropathy (AN) is a unique type of language developmental disorder, with no precise rate of genetic contribution that has been deciphered in a large cohort. In a retrospective cohort of 311 patients with AN, pathogenic and likely pathogenic variants of 23 genes were identified in 98 patients (31.5% in 311 patients), and 14 genes were mutated in two or more patients. Among subgroups of patients with AN, the prevalence of pathogenic and likely pathogenic variants was 54.4% and 56.2% in trios and families, while 22...
March 8, 2024: Human Genetics
https://read.qxmd.com/read/38454809/pyridostigmine-attenuated-high-fat-diet-induced-liver-injury-by-the-reduction-of-mitochondrial-damage-and-oxidative-stress-via-%C3%AE-7nachr-and-m3achr
#14
REVIEW
Runqing Xue, Qing Wu, Lulu Guo, Dan Ye, Qing Cao, Meng Zhang, Yushan Xian, Minchun Chen, Kangkang Yan, Jie Zheng
Obesity is a major cause of nonalcohol fatty liver disease (NAFLD), which is characterized by hepatic fibrosis, lipotoxicity, inflammation, and apoptosis. Previous studies have shown that an imbalance in the autonomic nervous system is closely related to the pathogenesis of NAFLD. In this study, we investigated the effects of pyridostigmine (PYR), a cholinesterase (AChE) inhibitor, on HFD-induced liver injury and explored the potential mechanisms involving mitochondrial damage and oxidative stress. A murine model of HFD-induced obesity was established using the C57BL/6 mice, and PYR (3 mg/kg/d) or placebo was administered for 20 weeks...
March 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38444138/-role-of-mitochondrial-dynamics-in-diabetic-cardiomyopathy-and-regulatory-mechanisms
#15
REVIEW
Huan Yue, De-Ma De, Ming-Ge Ding, Feng Fu
Cardiovascular complications are the leading cause of death in diabetic patients. Among them, diabetic cardiomyopathy (DCM) is a type of specific cardiomyopathy excluding myocardial damage caused by hypertension and coronary heart disease. It is characterized by abnormal metabolism of cardiomyocytes and gradual decline of cardiac function. The clinical manifestations of DCM are impaired diastolic function in early stage and impaired systolic function in late stage. Eventually it developed into heart failure...
February 25, 2024: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://read.qxmd.com/read/38439927/cd62e-and-ros-responsive-ets-improves-cartilage-repair-by-inhibiting-endothelial-cell-activation-through-opa1-mediated-mitochondrial-homeostasis
#16
JOURNAL ARTICLE
Pengcheng Tu, Yalan Pan, Lining Wang, Bin Li, Xiaoxian Sun, Zhongqing Liang, Mengmin Liu, Zitong Zhao, Chengjie Wu, Jianwei Wang, Zhifang Wang, Yu Song, Yafeng Zhang, Yong Ma, Yang Guo
Background: In the environment of cartilage injury, the activation of vascular endothelial cell (VEC), marked with excessive CD62E and reactive oxygen species (ROS), can affect the formation of hyaluronic cartilage. Therefore, we developed a CD62E- and ROS-responsive drug delivery system using E-selectin binding peptide, Thioketal, and silk fibroin (ETS) to achieve targeted delivery and controlled release of Clematis triterpenoid saponins (CS) against activated VEC, and thus promote cartilage regeneration. Methods: We prepared and characterized ETS/CS and verified their CD62E- and ROS-responsive properties in vitro...
2024: Biomaterials Research
https://read.qxmd.com/read/38419397/atf4-dependent-increase-in-mitochondrial-endoplasmic-reticulum-tethering-following-opa1-deletion-in-skeletal-muscle
#17
JOURNAL ARTICLE
Antentor Hinton, Prasanna Katti, Margaret Mungai, Duane D Hall, Olha Koval, Jianqiang Shao, Zer Vue, Edgar Garza Lopez, Rahmati Rostami, Kit Neikirk, Jessica Ponce, Jennifer Streeter, Brandon Schickling, Serif Bacevac, Chad Grueter, Andrea Marshall, Heather K Beasley, Young Do Koo, Sue C Bodine, Nayeli G Reyes Nava, Anita M Quintana, Long-Sheng Song, Isabella M Grumbach, Renata O Pereira, Brian Glancy, E Dale Abel
Mitochondria and endoplasmic reticulum (ER) contact sites (MERCs) are protein- and lipid-enriched hubs that mediate interorganellar communication by contributing to the dynamic transfer of Ca2+ , lipid, and other metabolites between these organelles. Defective MERCs are associated with cellular oxidative stress, neurodegenerative disease, and cardiac and skeletal muscle pathology via mechanisms that are poorly understood. We previously demonstrated that skeletal muscle-specific knockdown (KD) of the mitochondrial fusion mediator optic atrophy 1 (OPA1) induced ER stress and correlated with an induction of Mitofusin-2, a known MERC protein...
February 28, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38417589/human-neural-stem-cells-promote-mitochondrial-genesis-to-alleviate-neuronal-damage-in-mptp-induced-cynomolgus-monkey-models
#18
JOURNAL ARTICLE
Ying He, Ruicheng Li, Yuxi Yu, Chusheng Huang, Zhiran Xu, Tianbao Wang, Ming Chen, Hongri Huang, Zhongquan Qi
Currently, there is no effective treatment for Parkinson's disease (PD), and the regenerative treatment of neural stem cells (NSCs) is considered the most promising method. This study aimed to investigate the protective effect and mechanism of NSCs on neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced cynomolgus monkey (Macaca fascicularis) model of PD. We first found that injecting NSCs into the subarachnoid space relieved motor dysfunction in PD cynomolgus monkeys, as well as reduced dopaminergic neuron loss and neuronal damage in the substantia nigra (SN) and striatum...
February 28, 2024: Neurochemistry International
https://read.qxmd.com/read/38414856/optic-atrophy-1-mediates-muscle-differentiation-by-promoting-a-metabolic-switch-via-the-supercomplex-assembly-factor-scaf1
#19
JOURNAL ARTICLE
Matthew Triolo, Nicole Baker, Soniya Agarwal, Nikita Larionov, Tina Podinić, Mireille Khacho
Myogenic differentiation is integral for the regeneration of skeletal muscle following tissue damage. Though high-energy post-mitotic muscle relies predominantly on mitochondrial respiration, the importance of mitochondrial remodeling in enabling muscle differentiation and the players involved are not fully known. Here we show that the mitochondrial fusion protein OPA1 is essential for muscle differentiation. Our study demonstrates that OPA1 loss or inhibition, through genetic and pharmacological means, abolishes in vivo muscle regeneration and in vitro myotube formation...
March 15, 2024: IScience
https://read.qxmd.com/read/38413032/effect-of-electroacupuncture-of-governor-vessel-on-mitochondrial-fusion-and-proliferation-and-differentiation-of-neural-stem-cells-in-spinal-cord-injury-rats
#20
JOURNAL ARTICLE
Ming-Li Wu, Zhao-Yuan Duan, Wen-Tao Chang, Jing Gao, Kai-Qi Su, Xiao-Dong Feng
OBJECTIVES: To observe the effect of electroacupuncture (EA) at "Dazhui" (GV14) and "Jizhong"(GV6) of the Governor Vessel (GV) on mitochondrial fusion and neural stem cell (NSC) proliferation and differentiation in the spinal cord of rats with spinal cord injury (SCI), so as to investigate its mechanisms underlying improvement of SCI. METHODS: SD rats were randomly divided into sham operation, model and EA groups, with 15 rats in each group. The SCI model was established by using a precision impactor...
February 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
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