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https://www.readbyqxmd.com/read/29035440/impact-of-ph-on-urine-chemistry-assayed-on-roche-analyzers
#1
R Cohen, R Alkouri, I Tostivint, S Djiavoudine, F Mestari, S Dever, G Atlan, C Devilliers, F Imbert-Bismut, D Bonnefont-Rousselot, D Monneret
BACKGROUND: The pH may impact the concentration of certain urinary parameters, making urine pre-treatment questionable. METHODS: 1) Determining the impact of pH in vitro on the urinary concentration of chemistry parameters assayed on Roche Modular analyzers. 2) Evaluating whether concentrations depended on pH in non-pretreated urines from patients. RESULTS: 1) The optimal urinary pH values for each measurement were: 6.3 ± 0.8 (amylase), < 5...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035437/serum-uric-acid-levels-and-the-risk-of-obesity-a-longitudinal-population-based-epidemiological-study
#2
Rongjiong Zheng, Changxi Chen, Tianmeng Yang, Qingmei Chen, Rongdan Lu, Yushan Mao
BACKGROUND: Obesity is a common chronic disease, and elevated serum uric acid has been suggested to be associated with obesity. However, whether the elevation is casual or a consequence of obesity remains unclear. We performed the study to investigate the longitudinal association between serum uric acid levels and obesity. METHODS: A total of 4411 initially obesity-free subjects were followed up for 9 years. The subjects were divided into groups according to the serum uric acid quartile...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035321/a-novel-multi-epitope-vaccine-based-on-urate-transporter-1-alleviates-streptozotocin-induced-diabetes-by-producing-anti-urat1-antibody-and-an-immunomodulatory-effect-in-c57bl-6j-mice
#3
Yanjie Ma, Huimin Cao, Zhixin Li, Jinzhi Fang, Xiaomin Wei, Peng Cheng, Rui Jiao, Xiaoran Liu, Ya Li, Yun Xing, Jiali Tang, Liang Jin, Taiming Li
Hyperuricemia (HUA) is related to diabetes. Uric acid-induced inflammation and oxidative stress are risk factors for diabetes and its complications. Human urate transporter 1 (URAT1) regulates the renal tubular reabsorption of uric acid. IA-2(5)-P2-1, a potent immunogenic carrier designed by our laboratory, can induce high-titer specific antibodies when it carries a B cell epitope, such as B cell epitopes of DPP4 (Dipeptidyl peptidase-4), xanthine oxidase. In this report, we describe a novel multi-epitope vaccine composing a peptide of URAT1, an anti-diabetic B epitope of insulinoma antigen-2(IA-2) and a Th2 epitope (P2:IPALDSLTPANED) of P277 peptide in human heat shock protein 60 (HSP60)...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29035044/nicotine-alters-the-gut-microbiome-and-metabolites-of-gut-brain-interactions-in-a-sex-specific-manner
#4
Liang Chi, Ridwan Mahbub, Bei Gao, Xiaoming Bian, Pengcheng Tu, Hongyu Ru, Kun Lu
As the primary active substance in tobacco, nicotine affects the activity of the central nervous system, and its effects are sex-dependent. There are complex interactions between the gut and brain, and the gut microbiome can influence neuronal activity and host behavior, with diverse chemical signaling being involved. However, it is unclear whether nicotine can affect the normal gut microbiome and associated chemical signaling of the gut-brain axis. Sex is an important factor that shapes the gut microbiome, but the role of sex in the interaction among nicotine, gut bacteria, and related metabolites remains unknown...
October 16, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29034196/protective-effect-of-ethyl-acetate-fraction-of-biophytum-sensitivum-extract-against-sodium-oxalate-induced-urolithiasis-in-rats
#5
Anil T Pawar, Niraj S Vyawahare
The methanolic whole plant extract of Biophytum sensitivum (gǎnyìng cǎo) has been found to possess antiurolithiatic effect. The present study was undertaken to evaluate the antiurolithiatic effect of some fractions of methanolic whole plant extract of B. sensitivum (MBS) in rats as a step toward activity-directed isolation of antiurolithiatic component. The MBS was successively extracted with dichloromethane, ethyl acetate, ethanol and water to obtain fractions. Sodium oxalate (70 mg/kg, i.p.) was administered to rats for seven days to develop calcium oxalate urolithiasis...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033310/relation-of-elevated-serum-uric-acid-levels-to-first-degree-heart-block-and-other-cardiac-conduction-defects-in-hospitalized-patients-with-type-2-diabetes
#6
Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Giovanni Morani, Stefano Bonapace, Clementina Dugo, Giacomo Zoppini, Enzo Bonora, Giovanni Targher
AIMS: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM. METHODS: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014...
September 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29032376/impact-of-uric-acid-levels-on-kidney-disease-progression
#7
Hernan Rincon-Choles, Stacey E Jolly, Susana Arrigain, Victoria Konig, Jesse D Schold, Georges Nakhoul, Sankar D Navaneethan, Joseph V Nally, Michael B Rothberg
BACKGROUND: Hyperuricemia is associated with the progression of chronic kidney disease (CKD), but it is not known whether the relationship is causal. We examined the association of hyperuricemia and uric acid lowering therapy (UALT) with progression of CKD in patients with CKD 3 and 4 in the Cleveland Clinic CKD registry. METHODS: We included 1,676 patients with CKD stages 3 and 4 from Ohio, who had measured their uric acid (UA) levels a year prior to the recording of the second eGFR <60 mL/min/1...
October 13, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/29031886/zif-67-derived-porous-co3o4-hollow-nanopolyhedron-functionalized-solution-gated-graphene-transistors-for-simultaneous-detection-of-glucose-and-uric-acid-in-tears
#8
Can Xiong, Tengfei Zhang, Weiyu Kong, Zhixiang Zhang, Hao Qu, Wei Chen, Yanbo Wang, Linbao Luo, Lei Zheng
Biomarkers in tears have attracted much attention in daily healthcare sensing and monitoring. Here, highly sensitive sensors for simultaneous detection of glucose and uric acid are successfully constructed based on solution-gated graphene transistors (SGGTs) with two separate Au gate electrodes, modified with GOx-CHIT and BSA-CHIT respectively. The sensitivity of the SGGT is dramatically improved by co-modifying the Au gate with ZIF-67 derived porous Co3O4 hollow nanopolyhedrons. The sensing mechanism for glucose sensor is attributed to the reaction of H2O2 generated by the oxidation of glucose near the gate, while the sensing mechanism for uric acid is due to the direct electro-oxidation of uric acid molecules on the gate...
October 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29030163/metabolites-related-to-renal-function-immune-activation-and-carbamylation-are-associated-with-muscle-composition-in-older-adults
#9
Michael S Lustgarten, Roger A Fielding
Reduced skeletal muscle density in older adults is associated with insulin resistance, decreased physical function, and an increased all-cause mortality risk. To elucidate mechanisms that may underlie the maintenance of skeletal muscle density, we conducted a secondary analysis of previously published muscle composition and serum metabolomic data in 73 older adults (average age, 78y). Multivariable-adjusted linear regression was used to examine associations between 321 metabolites with muscle composition, defined as the ratio between normal density (NDM) with low density (LDM) thigh muscle cross sectional area (NDM/LDM)...
October 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29029738/a-redox-modulated-fluorescent-strategy-for-the-highly-sensitive-detection-of-metabolites-by-using-graphene-quantum-dots
#10
Hua Liu, Xing Li, Mengke Wang, Xueqian Chen, Xingguang Su
In this paper, a redox-modulated fluorescent strategy based on the transformation of Fe(2+)/Fe(3+) couple and enzymatic reaction for rapid monitoring glucose and uric acid using graphene quantum dots (GQDs) as fluorescent probe was developed. Hydrogen peroxide (H2O2) can be produced by the enzymatic reaction of a series of metabolites, such as glucose and uric acid. In the presence of hydrogen peroxide, Fe(2+) can be oxidized and converted to Fe(3+), which have a significant quenching difference in the fluorescence of graphene quantum dots (GQDs)...
October 16, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29029600/clinical-features-and-ckd-related-quality-of-life-in-patients-with-ckd-g3a-and-ckd-g3b-in-china-results-from-the-chinese-cohort-study-of-chronic-kidney-disease-c-stride
#11
Zhangzhe Peng, Jinwei Wang, Qiongjing Yuan, Xiangcheng Xiao, Hui Xu, Yanyun Xie, Wei Wang, Ling Huang, Yong Zhong, Xiang Ao, Luxia Zhang, Minghui Zhao, Lijian Tao, Qiaoling Zhou
BACKGROUND: This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chinese patients with CKD. METHODS: Participants with stage 3 CKD (18-74 years of age) were recruited at 39 clinical centers located at 28 cities in 22 provinces of China. The sociodemographic status, medical history, anthropometric measurements, and lifestyle behaviors were documented at entry, and blood and urine samples were collected...
October 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29029210/lesinurad-monotherapy-in-gout-patients-intolerant-to-a-xanthine-oxidase-inhibitor-a-6-month-phase-3-clinical-trial-and-extension-study
#12
Anne-Kathrin Tausche, Rieke Alten, Nicola Dalbeth, Jeff Kopicko, Maple Fung, Scott Adler, Nihar Bhakta, Chris Storgard, Scott Baumgartner, Kenneth Saag
Objective: To investigate the efficacy and safety of lesinurad, a selective uric acid reabsorption inhibitor, in a 6 month, phase 3 clinical trial and extension study. Methods: Patients with gout who cannot take a xanthine oxidase inhibitor (XOI) and have serum uric acid (sUA) ⩾6.5 mg/dl were randomized to receive oral lesinurad (400 mg daily) or placebo. The primary endpoint was the proportion of patients with sUA <6.0 mg/dl at month 6. Safety assessments included treatment-emergent adverse events (TEAEs) and laboratory data...
September 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/29028660/cumulative-exposure-of-tenofovir-disoproxil-fumarate-is-associated-with-kidney-tubulopathy-whether-it-is-currently-used-or-discontinued-in-hiv-infected-patients
#13
Takeshi Nishijima, Yoshikazu Mutoh, Yohei Kawasaki, Kiyomi Tomonari, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
OBJECTIVE: TDF increases the risk of kidney tubular dysfunction (KTD). This study was conducted to elucidate whether KTD persists after discontinuation of TDF. DESIGN: A prospective cross-sectional study which enrolled 941 HIV-1-infected patients. METHODS: KTD was predefined as the presence of at least two abnormalities among the five tubular markers (fractional excretion of phosphate, fractional excretion of uric acid, β2-microglobulinuria, N-acetyl-β-D-glucosaminidase, non-diabetic glycosuria)...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29028079/potency-on-lowering-serum-uric-acid-in-gout-patients-a-pooled-analysis-of-registrative-studies-comparing-febuxostat-vs-allopurinol
#14
M Cutolo, M A Cimmino, F Perez-Ruiz
OBJECTIVE: Hyperuricemia leading to urate crystal formation in tissues represents the pathophysiological mechanism of gout. Guidelines recommend a therapeutic target of serum urate concentration (sUA) <6 mg/dL, or even lower (≤5 mg/dL) in patients with large deposits. We conducted an analysis with the aim to achieve additional insights into the urate-lowering efficacy of two xanthine oxidase inhibitors, allopurinol and febuxostat. PATIENTS AND METHODS: This was a pooled analysis of phase III trials on allopurinol and febuxostat, including 4101 patients with gout and hyperuricemia...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027691/serum-adenosine-deaminase-and-xanthine-oxidase-activities-in-silver-catfish-naturally-infected-with-ichthyophthirius-multifiliis-the-influence-of-these-enzymes-on-inflammatory-and-oxidative-status
#15
M D Baldissera, C F Souza, P H Doleski, S G Monteiro, A S da Silva, B Baldisserotto
Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals...
October 13, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29025321/rutin-ameliorates-oxidative-stress-and-preserves-hepatic-and-renal-functions-following-exposure-to-cadmium-and-ethanol
#16
Sunny O Abarikwu, Rex-Clovis Njoku, Chiamaka J Lawrence, Iniobong A Charles, Jude C Ikewuchi
CONTEXT: Rutin (RUT) is an antioxidant flavonoid with well-known metal chelating potentials. OBJECTIVE: This study was designed to evaluate the protective effects of RUT against cadmium (Cd) + ethanol (EtOH)-induced hepatic and renal toxicity in rats. MATERIALS AND METHODS: Wistar rats were treated with Cd (50 mg/kg) alone or in combination with EtOH (5 mg/kg) and RUT (25, 50 and 100 mg/kg) for 15 days. After treatment, the liver, kidney and serum were removed for biochemical assays by spectrophotometric methods...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29024864/association-between-serum-uric-acid-level-and-renal-arteriolar-hyalinization-in-individuals-without-chronic-kidney-disease
#17
Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Naoki Haruyama, Yasuhiro Okabe, Masafumi Nakamura, Kazuhiko Tsuruya, Takanari Kitazono
BACKGROUND AND AIMS: Recent studies have reported an association between serum uric acid (SUA) and renal arteriolar changes in patients with chronic kidney disease (CKD). However, the association in individuals without CKD remains unclear. In this study, we investigated the relationship between SUA and renal arteriolar lesions in individuals without CKD from our living kidney donor cohort. METHODS: Between January 2006 and May 2016, 393 living kidney donors underwent "time-zero" biopsy at Kyushu University Hospital...
September 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29024064/physiological-and-health-related-response-of-broiler-chickens-fed-diets-containing-raw-full-fat-soya-bean-meal-supplemented-with-microbial-protease
#18
M M Erdaw, R A Perez-Maldonado, P A Iji
A 2 × 3 factorial study (protease: 0 or 1,5000 PROT/kg and raw full-fat soya bean meal [RSBM] replacing the commercial SBM at 0, 45 and 75 g/kg of diet) was conducted to examine the performance of broilers. Phytase (2000 FYT/kg) was uniformly added to each diet, each also replicated six times, with eight birds per replicate. Birds were raised in climate-controlled rooms using sawdust as the bedding material and offered starter, grower and finisher diets. Feed intake (FI) and body weight gain (BWG) were reduced (p < ...
October 10, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29020824/biomarkers-of-oxidative-stress-and-protein-protein-interaction-in-chronic-obstructive-pulmonary-disease
#19
Taru Aggarwal, Ridhima Wadhwa, Vishwajeet Rohil, Pawan Kumar Maurya
CONTENT: The increased oxidative stress in chronic obstructive pulmonary disease (COPD) patients is the result of increased inhaled oxidants, generated by various cells of the airways. OBJECTIVE: The investigation included measurements of malondiadehyde (MDA), uric acid, ascorbic acid, and matrix metalloproteinase-12 (MMP-12) in COPD patient. We also performed genetic analysis for protein-protein interaction (PPI) network. MATERIALS AND METHODS: The study was conducted on healthy subjects with normal lung function (NS, 14 subjects) and 28 patients (Global Initiative for Chronic Obstructive Lung Disease (Gold) 1 and Gold 2) with COPD...
October 11, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29019366/moderation-of-hyperuricemia-in-rats-via-consuming-walnut-protein-hydrolysate-diet-and-identification-of-new-antihyperuricemic-peptides
#20
Qingyong Li, Xiaoyan Kang, Chuanchao Shi, Yujuan Li, Kaustav Majumder, Zhengxiang Ning, Jiaoyan Ren
In this study, walnut meal hydrolysates (WMH) and dephenolized walnut meal hydrolysates (DWMH) were found to effectively decrease the serum uric acid level and protect the renal function in potassium oxonate-induced hyperuricemic rats in vivo as well as inhibit xanthine oxidase in vitro. Two novel antihyperuricemic peptides including WPPKN (640.8 Da) and ADIYTE (710.7 Da) were purified from DWMH via Sephadex G-15 gel filtration and reverse-phase high-performance liquid chromatography and identified by LC-ESI-MS/MS...
October 11, 2017: Food & Function
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