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Niki Katsiki, Konstantinos Tsioufis, Dilek Ural, Massimo Volpe
There is an unmet need to prevent cardiovascular disease and chronic kidney disease development and progression worldwide. Losartan, the first angiotensin receptor blocker, was shown to exert significant cardioprotective and renoprotective effects in the LIFE (Losartan Intervention for Endpoint Reduction in Hypertension) and RENAAL (Reduction of Endpoints in NIDDM With the Angiotensin II Antagonist Losartan) trials. Losartan significantly prevented stroke and decreased serum uric acid levels and the rates of new-onset diabetes mellitus and atrial fibrillation...
June 15, 2018: Journal of Clinical Hypertension
Rajesh Kumar Pathak, Ayushi Gupta, Rohit Shukla, Mamta Baunthiyal
Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation during purine catabolism. Uncontrolled expression of this enzyme is responsible for overproduction and deposition of uric acid in blood that is potentially injurious because it can breakdown DNA and protein molecules, triggering many diseases. Human Xanthine oxidoreductase (HsXOR) is considered to be a pharmacological target for the treatment of hyperuricemia. Many of the HsXOR-inhibitor drugs such as Febuxostat and Allopurinol are known to have significant adverse effects...
May 28, 2018: Computational Biology and Chemistry
Dimitrios A Savva, Nicole Herrera, Radha Rohatgi
BACKGROUND: The American Society of Clinical Oncology guidelines recommend rasburicase for the treatment of pediatric patients with hyperuricemia at risk of tumor lysis syndrome (TLS) using a weight-based dose of 0.1-0.2 mg/kg once daily for 1-7 days. However, there has been a trend in practice due to recent data showing benefit using a fixed-dose approach. The purpose of this study was to evaluate the efficacy and safety between fixed and weight-based dosing of rasburicase in a pediatric population...
June 15, 2018: Pediatric Blood & Cancer
Anna Marco-Ramell, Sara Tulipani, Magali Palau-Rodriguez, Raul Gonzalez-Dominguez, Antonio Miñarro, Olga Jauregui, Alex Sanchez-Pla, Manuel Macias-Gonzalez, Fernando Cardona, Francisco J Tinahones, Cristina Andres-Lacueva
This study explores the metabolic profiles of concordant/discordant phenotypes of high insulin resistance (IR) and obesity. Through untargeted metabolomics (LC-ESI-QTOF-MS), we analyzed the fasting serum of subjects with high IR and/or obesity ( n = 64). An partial least-squares discriminant analysis with orthogonal signal correction followed by univariate statistics and enrichment analysis allowed exploration of these metabolic profiles. A multivariate regression method (LASSO) was used for variable selection and a predictive biomarker model to identify subjects with high IR regardless of obesity was built...
June 15, 2018: Journal of Proteome Research
Perdana Samekto Tyasnugroho Suyoto
Meta-analysis was conducted to clarify the effect of low carbohydrate diet (LCD) on renal function in patients with type 2 diabetes mellitus (T2DM). An extensive literature search was conducted on scientific databases including PubMed, Scopus, and Cochrane Library until September 2017. Only controlled trials on human subjects written in English were included in this meta-analysis. Several markers of renal function were compared between subjects who adopted a LCD or control diet, including estimated glomerular filtration rate (eGFR), creatinine clearance, urinary albumin, serum creatinine, and serum uric acid...
June 14, 2018: Diabetes/metabolism Research and Reviews
Yadi Zhang, Fandi Zhang, Li Zhao, Jiancai Du, Yun Wang, Zhongqin Guo
OBJECTIVE: To investigate the relationship between SLC22A12 gene rs1529909 and rs7929627 polymorphism and hyperuricemia of residents in Yinchuan, Ningxia province. METHODS: Through retrospective analysis in healthy subjects from April to November in 2014, 365 patients with hyperuricemia were selected. 1∶ 1 matched casecontrol study was carried out, matched with age( ± 5 years old), gender, race, and selected 365 people with normal serum uric acid levels as the control group...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Xialian Lei, Renfu Li, Datao Tu, Xiaoying Shang, Yan Liu, Wenwu You, Caixia Sun, Fan Zhang, Xueyuan Chen
Near-infrared (NIR) II luminescence between 1000 and 1700 nm has attracted reviving interest for biosensing due to its unique advantages such as deep-tissue penetration and high spatial resolution. Traditional NIR-II probes such as organic fluorophores usually suffer from poor photostability and potential long-term toxicity. Herein, we report the controlled synthesis of monodisperse NaCeF4 :Er/Yb nanocrystals (NCs) that exhibit intense NIR-II emission upon excitation at 980 nm. Ce3+ in the host lattice was found to enhance the luminescence of Er3+ at 1530 nm with a maximum NIR-II quantum yield of 32...
May 28, 2018: Chemical Science
Manal M Alem, Abdullah M Alshehri, Peter Mb Cahusac, Matthew R Walters
Background: The xanthine oxidase inhibitor allopurinol improves endothelial function in different populations, including patients with chronic heart failure (CHF). Its effect on arterial stiffness parameters is less clear. We investigated the effect of short-term low-dose allopurinol therapy on arterial stiffness in Saudi patients with stable mild-moderate CHF. Methods: A prospective, randomized, double-blind, placebo-controlled study was performed on 73 patients with mild-moderate CHF...
2018: Clinical Medicine Insights. Cardiology
C Mancusi, R Izzo, L A Ferrara, F Rozza, M A Losi, G Canciello, M Pepe, N de Luca, B Trimarco, G de Simone
BACKGROUND AND AIMS: Circulating uric acid (UA) is positively associated with body mass index (BMI), blood glucose, blood pressure (BP), markers of inflammation, and altered lipid profile. UA has also anti-oxidative properties which might be beneficial for cardiovascular (CV) system. It is still debated whether or not UA is independently associated with increased CV morbidity and/or mortality. METHODS AND RESULTS: We studied prognostic impact of UA in 8833 hypertensive adults (mean age 53 ± 12 yrs, 3857 women) from the Campania Salute Network, without prevalent CV disease and more than stage 3 CKD...
May 4, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Jarunee Leetheeragul, Dittakarn Boriboonhirunsarn, Kanit Reesukumal, Nusara Srisaimanee, Siriluck Horrasith, Tuangsit Wataganara
INTRODUCTION: There is little information on the effect of maternal characteristics and on-admission laboratory parameters to the therapeutic serum magnesium sulfate (MgSO4) levels in women with preeclampsia (PE). We sought to identify factors that may predict timely attainment of therapeutic serum magnesium levels after intravenous administration for seizure prophylaxis. MATERIALS AND METHODS: On-admission factors of 360 women with PE who received intravenous MgSO4 (4-g loading and 2-g/hr maintenance) for seizure prophylaxis were retrospectively reviewed...
June 13, 2018: Journal of Maternal-fetal & Neonatal Medicine
Kimberly A Maciolek, Kristina L Penniston, R Allan Jhagroo, Sara L Best
INTRODUCTION AND OBJECTIVES: To examine the association of glycemic control, including strict glycemic control, with 24-hour (24-h) urine risk factors for uric acid and calcium calculi. MATERIALS AND METHODS: With IRB approval, we identified 183 stone formers (SFs) with 459 24-h urine collections. Hemoglobin A1c (HgbA1c) measures were obtained within 3 months of the urine collection. Collections were separated into normoglycemic (NG, HgbA1c<6.5) and hyperglycemic (HG, HgbA1c≥6...
June 13, 2018: Journal of Endourology
Atsushi Tanaka, Atsushi Kawaguchi, Hirofumi Tomiyama, Tomoko Ishizu, Chisa Matsumoto, Yukihito Higashi, Bonpei Takase, Toru Suzuki, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Akira Yamashina, Koichi Node
OBJECTIVES: The endothelial dysfunction-arterial stiffness-atherosclerosis continuum plays an important pathophysiological role in hypertension. The aim of this study was to investigate the cross-sectional association between serum uric acid (SUA) and vascular markers related to this continuum, and to assess the longitudinal association between SUA and endothelial function that represents the initial step of the continuum. METHODS: We evaluated the baseline associations between SUA levels and vascular markers that included flow-mediated vasodilatation (FMD), brachial-ankle pulse wave velocity (baPWV), and common carotid artery intima-media thickness (CCA-IMT) in 648 subjects receiving antihypertensive treatment...
June 6, 2018: International Journal of Cardiology
Lan-Zhu Li, Guo-Xiu Zhou, Jia Li, Wei Jiang, Bao-Lin Liu, Wen Zhou
Compounds containing trace elements copper or zinc are potential gout and hyperuricemia suppressant by virtue of their inhibiting effect on xanthine oxidase/xanthine dehydrogenase (XOD/XDH) and anti-inflammatory and anti-oxidative function. In this study, compounds Cu(hmy-paa)·SO4 ·H2 O (simplified as CuHP) and Zn(hmy-paa)·SO4 ·H2 O (simplified as ZnHP) are synthesized, where hmy-paa stands for 3-(4-hydroxy-3-methoxyphenyl)-N-(1H-pyrazol-3-yl)acrylamide). The ligand hmy-paa is composed of functional ferulic acid and 3-aminopyrazole...
September 2018: Journal of Trace Elements in Medicine and Biology
Fan Yang, Zhiyue Yu, Xinyi Li, Peipei Ren, Guanhong Liu, Youtao Song, Jun Wang
In this study, a novel fluorescent probe, TbIII -dtpa-bis(2,6-diaminopurine) (Tb-dtpa-bdap), is designed based on the principle of complementary base pairing and synthesized for uric acid detection. The synthesized fluorescent probe is characterized by 1 H NMR, 13 C NMR, infra-red (IR) spectrum and ultraviolet-visible (UV-vis) spectra. It is found that the fluorescence of Tb-dtpa-bdap solution can be quenched obviously in the presence of uric acid. The affecting factors, including solution acidity, uric acid concentration and interfering substances, on the detection of uric acid using this probe are examined...
June 3, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Ju Qin, Qian Nan, Jing Yang, Rui Yang
In this paper, the high performance fluorescent carbon dots were synthesized with maleic acid, tris and benzoic acid as raw materials by one-step hydrothermal method. The obtained carbon dots with uniform size emitted strong blue fluorescence, which the maximum excitation and emission wavelengths at 250 nm and 415 nm, respectively. Under the optimum condition, it was meaningfully founded that the reaction between the carbon dots and uric acid resulting in the fluorescence quenching of the carbon dots at the emission spectrum of 415 nm...
May 26, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Fan Wu, Jieli Huang, Jianhong Zhou
Adiponectin protects against the development of albuminuria in rodent experiments and patients with diabetic kidney disease. However, it is not clear whether higher circulating adiponectin levels have the same effect in patients with pregnancy-induced hypertension (PIH). Urine albumin excretion (UAE) is an easy to use test and a powerful index for routine management of PIH patients. This study aimed to investigate the relationship between serum total adiponectin and UAE in PIH patients. A total of 156 PIH patients were enrolled and divided into three groups according to adiponectin tertiles...
June 12, 2018: Clinical and Experimental Hypertension: CHE
Mohamed Rezk, Wael Gaber, Abdelhamid Shaheen, Ahmed Nofal, Mahmoud Emara, Awni Gamal, Hassan Badr
OBJECTIVE: To determine if second trimester mean platelet volume (MPV) and serum uric acid are reasonable predictors of preeclampsia (PE) or not, in patients at moderate and low risk. METHODS: This prospective study was conducted on 9522 women at low or moderate risk for developing PE who underwent dual measurements of MPV and serum uric acid at late first trimester (10-12 weeks) and at second trimester (18-20 weeks) and subsequently divided into two groups; PE group (n = 286) who later developed PE and non-PE group (n = 9236)...
June 12, 2018: Hypertension in Pregnancy
Brenna M G Gormally, Jessica Wright-Lichter, J Michael Reed, L Michael Romero
Despite decades of research, we still lack a complete understanding of what factors influence the transition of the necessary and adaptive acute stress response to what has become known as chronic stress. This gap in knowledge has illuminated the necessity for studies that examine the thresholds between these two sides of the stress response. Here, we determine how repeated exposure to acute stressors influences physiological and behavioral responses. In this repeated measures study, house sparrows ( Passer domesticus ) were exposed to a chronic stress protocol...
2018: PeerJ
Hyung Joon Joo, Han Saem Jeong, Hyungdon Kook, Seung Hun Lee, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu, Do-Sum Lim
BACKGROUND: There have been limited data on the impact of hyperuricemia on long-term clinical outcomes after percutaneous coronary intervention (PCI) for in-stent restenosis (ISR). METHODS: From January 2009 to July 2015, 317 patients who underwent repeat PCI for ISR were divided into two groups: patients with normal serum uric acid (UA) levels (normal UA group) and patients with higher serum UA levels (higher UA group). The higher UA group included patients with serum UA levels > 6...
June 11, 2018: BMC Cardiovascular Disorders
Lourdes Lorigados Pedre, Juan M Gallardo, Lilia M Morales Chacón, Angélica Vega García, Monserrat Flores-Mendoza, Teresa Neri-Gómez, Bárbara Estupiñán Díaz, Rachel M Cruz-Xenes, Nancy Pavón Fuentes, Sandra Orozco-Suárez
Oxidative stress (OS) has been implicated as a pathophysiological mechanism of drug-resistant epilepsy, but little is known about the relationship between OS markers and clinical parameters, such as the number of drugs, age onset of seizure and frequency of seizures per month. The current study&rsquo;s aim was to evaluate several oxidative stress markers and antioxidants in 18 drug-resistant partial complex seizure (DRPCS) patients compared to a control group (age and sex matched), and the results were related to clinical variables...
June 9, 2018: Behavioral Sciences
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