keyword
https://read.qxmd.com/read/37456916/eltrombopag-plus-cyclosporine-in-refractory-immune-thrombocytopenia-a-single-center-study
#21
JOURNAL ARTICLE
Yilei Hong, Yingying Shen, Qi Liu, Jingjie Dong, Jingjing Xiang, Yiping Shen, Liqiang Wu, Yuhong Zhou, Baodong Ye, Dijiong Wu
BACKGROUND: With the development of thrombopoietin receptor agonists, the prognosis of immune thrombocytopenia (ITP) in patients in whom there was a poor response to first-line treatment has greatly improved. However, there are still some patients who are refractory to eltrombopag. OBJECTIVES: To explore the efficacy and safety of eltrombopag combined with low-dose cyclosporine in the management of patients with refractory ITP. METHODS: A total of 21 participants with ITP who failed to respond to multiple lines of therapy (including a daily dose of 75 mg of eltrombopag for at least 30 days) treated at The First Affiliated Hospital of Zhejiang Chinese Medical University between January 2018 and August 2022 were included...
July 2023: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/37423421/chorea-following-sars-cov-2-infection-and-vaccination-a-systematic-review-of-reported-cases
#22
JOURNAL ARTICLE
Elena Cecilia Rosca, Raluca Bilavu, Amalia Cornea, Mihaela Simu
BACKGROUND: Chorea following SARS-CoV-2 infection and vaccination, has been increasingly recognized. We aimed to synthesize clinical and paraclinical characteristics, treatment responses, and outcomes of this neurologic complication. METHODS: We systematically reviewed LitCOVID, the WHO database on COVID-19, and MedRxiv up to March 2023, following a published protocol. RESULTS: We included 14 chorea cases in patients with SARS-CoV-2 infection and eight following COVID-19 vaccination...
July 7, 2023: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/37385325/infliximab-for-vascular-involvement-in-beh%C3%A3-et-s-syndrome
#23
JOURNAL ARTICLE
Gulen Hatemi, Nur Beyza Tukek, Sinem Nihal Esatoglu, Yesim Ozguler, Sitki Safa Taflan, Ugur Uygunoglu, Melike Melikoglu, Serdal Ugurlu, Izzet Fresko, Aksel Siva, Zekayi Kutlubay, Sebahattin Yurdakul, Hasan Yazici, Vedat Hamuryudan
OBJECTIVE: Vascular involvement is an important cause of morbidity and mortality in patients with Behçet's syndrome (BS). We aimed to survey the efficacy and safety of infliximab (IFX) in BS patients with vascular involvement followed in a dedicated tertiary center. METHODS: Charts of all BS patients who used IFX for vascular involvement between 2004 and 2022 were reviewed. Primary endpoint was remission at Month 6, defined as lack of new clinical symptoms and findings associated with vascular lesion, lack of worsening of the primary vascular lesion and a new vascular lesion on imaging, and CRP < 10 mg/L...
August 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/37363978/prevalence-patterns-and-predictors-of-venous-thromboembolic-events-in-patients-undergoing-salvage-chemotherapy-and-autologous-stem-cell-transplantation-for-relapsed-lymphomas
#24
JOURNAL ARTICLE
Mohammad Ma'koseh, Mohammad Alrwashdeh, Nayef Abdel-Razeq, Rozan Alfar, Sarah Edaily, Rayan Bater, Mais Zmaily, Mohammad Almomani, Hikmat Abdel-Razeq
BACKGROUND AND OBJECTIVES: Almost 25% of patients with lymphoma may have relapse or develop refractory disease, and a majority of such patients undergo salvage chemotherapy and autologous stem cell transplantation (ASCT). Data on venous thromboembolism (VTE) in this setting are scarce. This study aimed to investigate the prevalence and factors that may increase the risk of VTE in such patients. PATIENTS AND METHODS: Adult patients who were diagnosed with lymphoma and received salvage chemotherapy and ASCT were included in the study, and the subgroup with radiologically confirmed VTE were identified...
May 23, 2023: Hematology/oncology and Stem Cell Therapy
https://read.qxmd.com/read/37345389/-diagnosis-and-treatment-of-neuro-beh%C3%A3-et-a-clinical-update
#25
REVIEW
Lénia Silva, João Correia, Ernestina Santos
Behçet's disease is a relapsing multisystemic inflammatory syndrome characterized by recurrent oral and/or genital ulcers, uveitis, arthritis, skin lesions, and gastrointestinal and neurological involvement. Neuro-Behçet corresponds to nervous system involvement and is one of the most severe complications of Behçet disease. It occurs in 3% to 30% of cases and is categorized into parenchymal (most common) or non-parenchymal disease. The most common manifestation of parenchymal neuro-Behçet is meningoencephalitis with involvement of the brainstem, where patients present with cranial neuropathies, encephalopathy, sensory-motor syndromes, epilepsy, or myelitis...
June 21, 2023: Acta Médica Portuguesa
https://read.qxmd.com/read/37270177/sixth-cranial-nerve-palsy-and-dense-cerebral-venous-sinus-thrombosis-in-a-child-with-nephrotic-syndrome
#26
JOURNAL ARTICLE
Sucheta Parija, Nikita Dash, Genickson Jeyaraj
Nephrotic syndrome (NS) is a common glomerular disease characterised by massive proteinuria, hypoalbuminaemia, oedema and hyperlipidaemia. Cerebral venous sinus thrombosis (CVST) is a rare complication in children with NS. Here, we report a case of relapsing NS on steroid therapy, in a male in early childhood who presented with symptoms of headache, vomiting and double vision. On prism cover test there was 25 PD esotropia with abduction restriction in the left eye. Fundus examination showed bilateral papilloedema...
June 2, 2023: BMJ Case Reports
https://read.qxmd.com/read/37228533/a-triad-of-trichobezoar-rapunzel-syndrome-severe-malnutrition-and-cerebral-venous-thrombosis
#27
Minal Shastri, Darshankumar M Raval, Vaishnavi M Rathod, Shashwat Mallik, Shahin Khan
Trichobezoar is a rare condition almost exclusively seen in young females presenting with non-specific abdominal complaints and a history of psychiatric illness. In most patients, it is confined within the stomach; however, in some severe cases, it extends through the pylorus into the duodenum, jejunum, ileum, or even colon, known as Rapunzel syndrome. Conventional treatment includes laparotomy and psychiatric counseling to prevent relapses. We report the case of an 18-year-old female with no previous history of medical or psychiatric illness who presented with chief complaints of upper abdominal pain, nausea, occasional vomiting for the last six months, and generalized edema for the last three days...
April 2023: Curēus
https://read.qxmd.com/read/37176053/thrombotic-events-are-unusual-toxicities-of-chimeric-antigen-receptor-t-cell-therapies
#28
JOURNAL ARTICLE
Christopher Schorr, Jorge Forindez, Manuel Espinoza-Gutarra, Rakesh Mehta, Natalie Grover, Fabiana Perna
Chimeric antigen receptor (CAR) T-cell therapy has greatly transformed the treatment and prognosis of B-cell hematological malignancies. As CAR T-cell therapy continues to be more readily adopted and indications increase, the field's recognition of emerging toxicities will continue to grow. Among the adverse events associated with CAR T-cell therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) are the most common toxicities, while thrombotic events represent an under-reported, life-endangering complication...
May 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37150028/venous-thromboembolism-in-hematopoietic-stem-cell-transplantation-a-narrative-review
#29
REVIEW
Jodi Chiu, Alejandro Lazo-Langner
Venous thromboembolism (VTE) is a common complication of hematopoietic stem cell transplantation (HSCT) and its treatment has significant effects on morbidity and non-relapse mortality. There is a complex interplay on balancing the risk for thrombosis and bleeding in these patients, making treatment decisions particularly challenging. Despite this, there are currently no validated risk assessment models or guidelines to aid clinical decision making on thromboprophylaxis and VTE treatment in this population of patients...
June 2023: Thrombosis Research
https://read.qxmd.com/read/36938179/naproxen-induced-evans-syndrome
#30
Ange Ahoussougbemey Mele, Christopher Chew, Ruben Ruiz Vega, Riaz Mahmood, Riyadh AlRubaye
Evans syndrome is an autoimmune disorder characterized by the simultaneous occurrence of autoimmune hemolytic anemia and immune thrombocytopenic purpura. It can further be classified as primary Evans syndrome when it occurs by itself, or secondary Evans syndrome when it is associated with other autoimmune and lymphoproliferative disorders. Corticosteroids and immunoglobulins are the first-line treatments for primary Evans syndrome, and subsequent options include other immunosuppressive medications. Medical literature provides little information about the triggers of primary Evans syndrome...
February 2023: Curēus
https://read.qxmd.com/read/36933861/cerebral-venous-thrombosis-in-an-adult-with-relapsing-minimal-change-disease
#31
REVIEW
Matthias Bergmann, Thanh N Nguyen, Christine C Segal, Bertrand L Jaber
Minimal change disease (MCD) is a well-known cause of fulminant acute nephrotic syndrome (NS) and has been associated with thrombotic complications. We report the case of a 51-year-old woman with previously biopsy-proven MCD in remission who presented with headache and encephalopathy shortly after a relapse of the NS and was diagnosed with cerebral venous thrombosis (CVT) complicated by intracranial hemorrhage and midline shift. One month prior, she had been initiated on an oral contraceptive agent during remission of the NS...
March 16, 2023: American Journal of the Medical Sciences
https://read.qxmd.com/read/36894193/identifying-high-risk-profile-in-primary-antiphospholipid-syndrome-through-cluster-analysis-french-multicentric-cohort-study
#32
MULTICENTER STUDY
Alexis F Guedon, Laure Ricard, Charlotte Laurent, Claire De Moreuil, Geoffrey Urbanski, Sophie Deriaz, Grigorios Gerotziafas, Ismail Elalamy, Alexandra Audemard, Francois Chasset, Sonia Alamowitch, Jérémie Sellam, Jean Jacques Boffa, Ariel Cohen, Clémentine Wahl, Noemie Abisror, François Maillot, Olivier Fain, Arsène Mekinian
INTRODUCTION: Antiphospholipid syndrome (APS) is an autoimmune disease characterised by thrombosis (arterial, venous or small vessel) or obstetrical events and persistent antiphospholipid antibodies (aPL), according to the Sydney classification criteria. Many studies have performed cluster analyses among patients with primary APS and associated autoimmune disease, but none has focused solely on primary APS. We aimed to perform a cluster analysis among patients with primary APS and asymptomatic aPL carriers without any autoimmune disease, to assess prognostic value...
March 2023: RMD Open
https://read.qxmd.com/read/36837493/evaluation-of-low-molecular-weight-heparin-for-treatment-of-portal-vein-thrombosis-in-liver-cirrhosis-patients
#33
JOURNAL ARTICLE
Ji Min Han, Youngil Koh, Sung Hwan Kim, Sung Yun Suh, Yoon Sook Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Hye Sun Gwak
Background and Objectives: Even though low-molecular-weight heparin (LMWH), including dalteparin, has a critical role in portal vein thrombosis (PVT) treatment in liver cirrhosis (LC) patients, the predictive factors and the proper dose of dalteparin for PVT treatment and relapse have not yet been investigated. Materials and Methods: This retrospective study evaluated the records of LC patients receiving dalteparin from July 2013 to June 2019. The odds ratio (OR) and adjusted OR were calculated from univariate and multivariable analyses, respectively...
February 4, 2023: Medicina
https://read.qxmd.com/read/36676061/predicting-factors-for-seizures-after-cerebral-venous-thrombosis-a-retrospective-single-center-cohort-study
#34
JOURNAL ARTICLE
Francesca Colò, Valerio Brunetti, Mariangela Di Muro, Elena Rossi, Francesca Bartolomei, Andrea Maria Alexandre, Simone Bellavia, Irene Scala, Artur Słomka, Fabio Pilato, Giovanni Frisullo, Aldobrando Broccolini, Giacomo Della Marca
BACKGROUND: Seizures are a common complication of cerebral venous thrombosis. In this study, we intended to define clinical and neuroradiological factors associated with early and late seizures and predictors for seizure recurrence. METHODS: The database of our high-volume tertiary stroke center was screened for patients diagnosed with cerebral venous thrombosis between April 2006 and July 2021. Demographics, clinical, imaging, and instrumental data were collected...
December 30, 2022: Life
https://read.qxmd.com/read/36660571/cerebral-venous-thrombosis-secondary-to-ulcerative-colitis-a-case-report-with-a-literature-review
#35
Mohamed Hamid, Aziz Ahizoune, Maha Ait Berri
Ulcerative colitis is an idiopathic inflammatory bowel condition that may be worsened by thromboembolic events such deep vein thrombosis, cerebral venous thrombosis, and pulmonary embolism. Cerebral venous thrombosis is a rare but critical consequence of ulcerative colitis characterized by high mortality and morbidity rate. It is thought to be caused by the hypercoagulable state that occurs during ulcerative colitis relapse. Cerebral venous thrombosis is a reversible condition with good outcomes when detected early and treated properly...
March 2023: Radiology Case Reports
https://read.qxmd.com/read/36571427/eltrombopag-for-the-treatment-of-poor-graft-function-following-haematopoietic-cell-transplantation-real-life-data
#36
JOURNAL ARTICLE
Ekin Kırcalı, Güldane Cengiz Seval, Cemaleddin Öztürk, Hülya Yılmaz, Derya Koyun, Sinem Civriz Bozdağ, Selami Koçak Toprak, Pervin Topçuoğlu, Önder Arslan, Muhit Özcan, Taner Demirer, Osman İlhan, Günhan Gürman, Meral Beksaç, Meltem Kurt Yüksel
BACKGROUND: Eltrombopag has an off-label indication for haematopoietic cell transplantation in patients experiencing delayed thrombocyte recovery and/or thrombocytopaenia. AIMS: To present our centre’s experience of using this agent not only for post- haematopoietic cell transplantation thrombocytopaenia but also for poor graft functioning in the post-haematopoietic cell transplantation setting. STUDY DESIGN: Retrospective cross-sectional study...
January 23, 2023: Balkan Medical Journal
https://read.qxmd.com/read/36354782/combined-methylprednisolone-pulse-therapy-plus-rituximab-for-treating-a-rare-juvenile-steroid-resistant-nephrotic-syndrome-with-cerebral-venous-sinus-thrombosis-a-case-report
#37
Hader I Sakr, Burhan Edrees, Hussein Omar Taher, Tuleen Talal Miliany, Raneem Yasser Gazzaz, Asma Omar AlRuwaithi, Mohammed Fouad Alamer, Mostafa E Metawee
Background : Cerebral venous sinus thrombosis (CVST) secondary to nephrotic syndrome (NS) is rarely reported. Additionally, treating steroid-sensitive nephrotic syndrome (SSNS) that changes to steroid resistance (SRNS) is difficult, with many relapses and side effects. Case presentation : A 32-month-old SSNS male child turned into SRNS and developed cerebral venous sinus thrombosis (CVST), a rare complication of NS. As a result of the administration of combined pulse methylprednisolone and IV Rituximab (RTX) therapy, the patient showed marked improvement, the results of urine analysis were remarkably improved, and the child started to respond to treatment...
November 8, 2022: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/36259114/neurological-autoimmune-diseases-following-vaccinations-against-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-a-follow-up-study
#38
JOURNAL ARTICLE
Sofia Doubrovinskaia, Christoph M Mooshage, Corinna Seliger, Hanns-Martin Lorenz, Simon Nagel, Pascal Lehnert, Jan Purrucker, Brigitte Wildemann, Martin Bendszus, Wolfgang Wick, Silvia Schönenberger, Leon D Kaulen
BACKGROUND AND PURPOSE: Population-based studies suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may trigger neurological autoimmunity including immune-mediated thrombotic thrombocytopenia. Long-term characterization of cases is warranted to facilitate patient care and inform vaccine-hesitant individuals. METHODS: In this single-center prospective case study with a median follow-up of 387 days long-term clinical, laboratory and imaging characteristics of patients with neurological autoimmunity diagnosed in temporal association (≤6 weeks) with SARS-CoV-2 vaccinations are reported...
February 2023: European Journal of Neurology
https://read.qxmd.com/read/36177950/antiphospholipid-syndrome-in-patients-over-65-years-a-comparative-study-of-clinical-and-biological-features-and-thrombotic-relapses
#39
MULTICENTER STUDY
Colombe Masson, Thi T An Nguyen, Virginie Dufrost, Marie Audrain, Caroline Hémont, Christian Agard, Mathieu Artifoni, Jérôme Connault, Marc Fouassier, Mohamed Hamidou, Alexis F Guedon, Denis Wahl, Stéphane Zuily, Olivier Espitia
OBJECTIVE: The aim of the study was to describe clinical and biological characteristics and thrombotic relapses of patients diagnosed with antiphospholipid syndrome (APS) after the age of 65 years, in comparison with patients diagnosed with APS before 65. METHODS: This retrospective multicenter study was performed to 2005 from 2017 and included patients diagnosed with APS after the age of 65 years, in accordance with Sydney criteria. We compared these patients with APS patients diagnosed before the age of 65 years, and with control thrombotic patients older than 65 years...
December 2022: Lupus
https://read.qxmd.com/read/36082668/outcomes-of-cerebral-venous-thrombosis-due-to-vaccine-induced-immune-thrombotic-thrombocytopenia-after-the-acute-phase
#40
JOURNAL ARTICLE
Anita van de Munckhof, Erik Lindgren, Timothy J Kleinig, Thalia S Field, Charlotte Cordonnier, Katarzyna Krzywicka, Sven Poli, Mayte Sánchez van Kammen, Afshin Borhani-Haghighi, Robin Lemmens, Adrian Scutelnic, Alfonso Ciccone, Thomas Gattringer, Matthias Wittstock, Vanessa Dizonno, Annemie Devroye, Ahmed Elkady, Albrecht Günther, Alvaro Cervera, Annerose Mengel, Beng Lim Alvin Chew, Brian Buck, Carla Zanferrari, Carlos Garcia-Esperon, Christian Jacobi, Cristina Soriano, Dominik Michalski, Zohreh Zamani, Dylan Blacquiere, Elias Johansson, Elisa Cuadrado-Godia, Fabrice Vuillier, Felix J Bode, François Caparros, Frank Maier, Georgios Tsivgoulis, Hans D Katzberg, Jiangang Duan, Jim Burrow, Johann Pelz, Joshua Mbroh, Joyce Oen, Judith Schouten, Julian Zimmermann, Karl Ng, Katia Garambois, Marco Petruzzellis, Mariana Carvalho Dias, Masoud Ghiasian, Michele Romoli, Miguel Miranda, Miriam Wronski, Mona Skjelland, Mostafa Almasi-Dooghaee, Pauline Cuisenier, Seán Murphy, Serge Timsit, Shelagh B Coutts, Silvia Schönenberger, Simon Nagel, Sini Hiltunen, Sophie Chatterton, Thomas Cox, Thorsten Bartsch, Vahid Shaygannejad, Zahra Mirzaasgari, Saskia Middeldorp, Marcel M Levi, Johanna A Kremer Hovinga, Katarina Jood, Turgut Tatlisumak, Jukka Putaala, Mirjam R Heldner, Marcel Arnold, Diana Aguiar de Sousa, José M Ferro, Jonathan M Coutinho
BACKGROUND: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization. METHODS: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022...
September 9, 2022: Stroke; a Journal of Cerebral Circulation
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