keyword
https://read.qxmd.com/read/38440737/four-clinical-and-biological-phenotypes-in-antiphospholipid-syndrome-a-cluster-analysis-of-174-patients-with-antinuclear-antibody-tests
#1
JOURNAL ARTICLE
Marie Ottavi, Pierre Toulon, Barbara Casolla, Nihal Martis
INTRODUCTION: Antiphospholipid syndrome (APS) is an autoimmune thrombotic disease with various systemic presentations. This study aimed to identify homogeneous groups of patients based on a non-supervised hierarchical cluster analysis and assess the rate of relapse associated with antinuclear antibodies (ANA). METHODS: This retrospective observational study enrolled patients, over a 90-month period, who had APS as defined by the 2006 Sydney classification criteria, and for whom ANA workup was performed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38390439/cerebral-venous-sinus-thrombosis-in-a-patient-treated-with-ribociclib-for-metastatic-breast-cancer-case-reports-and-literature-review
#2
Baha Sharaf, Zeina Othman, Hala Abu Faris, Malak Al-Bitar, Qasem Al-Zoubi, Dima Abu Laban, Hala Abu-Jaish, Hikmat Abdel-Razeq
Breast cancer is the most diagnosed cancer among women worldwide. Cyclin dependent kinase 4/6 inhibitors (ribociclib, palbociclib, and abemaciclib) modulate endocrine resistance and are widely used treatment for patients with advanced-stage hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. Reports of both venous and arterial thromboembolic events, as a complication of cyclin dependent kinase 4/6 inhibitors, are increasingly recognized, but none involved cerebral venous sinus...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38357865/express-does-anticoagulation-in-combination-with-immunosuppressive-therapy-prevent-recurrent-thrombosis-in-beh%C3%A3-et-s-disease
#3
JOURNAL ARTICLE
Serhat Erol, Aslıhan Gürün Kaya, Fatma Arslan, Hasan Hasanzade, Ahmet Onur Daştan, Aydın Çiledağ, Banu Eriş Gülbay, Akın Kaya, Özlem Özdemir Kumbasar, Gökhan Çelik, Turan Acıcan
Vascular involvement in Behçet's Disease (BD) occurs in up to 50% of patients. The main mechanism of thrombosis is inflammation. Thus, immunosuppressants (IS) are the mainstay of therapy, and adding anticoagulants (AC) is controversial. In daily practice, we observed that patients who receive AC in combination with IS experience less recurrent thrombosis and decided to retrospectively investigate our Behçet's Disease patients. We hypothesized that adding anticoagulants to immunosuppressive therapy may lower the risk of recurrent thrombosis...
February 15, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/38256570/the-application-of-existing-risk-assessment-models-rams-to-predict-the-occurrence-of-venous-thromboembolic-events-among-patients-with-classic-hodgkin-lymphoma
#4
JOURNAL ARTICLE
Mohammad Ma'koseh, Alaa Abufara, Dana Albaghdadi, Ruba Ghalayni, Sarah Abdel-Razeq, Eman Alzughali, Fadwa Abdel Rahman, Yazan Alhalaseh, Khalid Halahleh, Hikmat Abdel-Razeq
Background: A majority of patients included in risk assessment models (RAMs) developed to predict venous thromboembolic events (VTE) in lymphoma were non-Hodgkin lymphoma. Our study aims to evaluate the incidence and predictors of VTE, utilizing different RAMs, in patients with classic Hodgkin lymphoma (cHL) treated with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD). Methods : Adult patients with cHL, treated and followed at our center, were included. Correlations between different variables, Khorana score, and thrombosis in lymphoma (ThroLy) RAMs with VTE were examined using Fisher's exact test and logistic regression analysis...
January 12, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38143657/poems-polyneuropathy-organomegaly-endocrinopathy-monoclonal-plasma-cell-disorder-and-skin-changes-syndrome-as-a-sequela-of-castleman-disease-a-case-report
#5
Syed Abdullah Haider, Sadia Iram, Asma Abdul Rashid, Anusha Manazar, Hamza Javed
Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a rare multisystemic paraneoplastic disorder caused by an underlying plasma cell dyscrasia. Its diagnosis is based on the presence of two mandatory criteria and at least one major and one minor criterion. We report a case of a 52-year-old female patient who presented with complaints of acrocyanosis, night sweats, scaly skin, and swelling on the left side of the neck. She was a known case of hypothyroidism, antiphospholipid syndrome, and cerebral venous thrombosis, and had other comorbidities as well...
November 2023: Curēus
https://read.qxmd.com/read/38064842/venous-thromboembolism-prophylaxis-and-multiple-myeloma-patients-in-real-life-results-of-a-large-survey-and-clinical-guidance-recommendations-from-the-ifm-group
#6
JOURNAL ARTICLE
Laurent Frenzel, Olivier Decaux, Margaret Macro, Karim Belhadj-Merzoug, Salomon Manier, Cyrille Touzeau, Xavier Leleu, Corinne Frère, Thomas Lecompte, Aurore Perrot, Hervé Avet-Loiseau, Philippe Moreau, Emilie Chalayer
Venous thromboembolism (VTE) remains a critical issue in the management of patients with multiple myeloma (MM), particularly when immunomodulatory drugs (IMiDs) combined with dexamethasone therapy are being prescribed as first-line and relapse therapy. One possible explanation for the persistent high rates of VTE, is the use of inappropriate thromboprophylaxis strategies for patients starting antimyeloma treatment. To tackle the issue, the Intergroupe francophone du myélome (IFM) offered convenient guidance for VTE thromboprophylaxis in MM patients initiating systemic therapy...
December 2, 2023: Thrombosis Research
https://read.qxmd.com/read/37955334/cutaneous-vasculitis-in-autoinflammatory-diseases
#7
REVIEW
Ko-Ron Chen
Autoinflammatory diseases (AIDs) characterized by recurrent episodes of localized or systemic inflammation are disorders of the innate immune system. Skin lesions are commonly found in AIDs and cutaneous vasculitis can coexist with AIDs and even present as the most striking feature. This review aims to focus on the frequent cutaneous vasculitis association in three monogenic AIDs including familial Mediterranean fever (FMF), deficiency of adenosine deaminase type 2 (DADA2), and the recently identified adult-onset VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome...
November 13, 2023: Journal of Dermatology
https://read.qxmd.com/read/37953819/short-course-versus-prolonged-course-antimicrobial-therapy-in-adults-with-catheter-related-septic-thrombosis-a-propensity-weighted-retrospective-study
#8
JOURNAL ARTICLE
Marine Stoldick, Margot Vannier, Mikael Verdalle-Cazes, Manuel Etienne, Kévin Alexandre
BACKGROUND: Optimal duration of antimicrobial therapy (AT) for catheter-related septic deep venous thrombosis (DVT) is unknown. We aimed to compare the outcomes of patients receiving short-course AT (≤21 days) versus prolonged-course AT (>21 days). METHODS: This was a monocentric retrospective study comparing adults with catheter-related septic DVT from 2015 to 2020 treated with short- or prolonged-course AT. A propensity score-weighted analysis was used to mitigate potential bias...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37932973/comparison-of-the-efficacy-and-safety-of-ultrasound-guided-chiva-and-traditional-hls-in-the-treatment-of-varicose-veins-of-lower-extremities-a-meta-analysis
#9
JOURNAL ARTICLE
Yueying Pei, Chuntao Li, Shuai Niu, Kun Jia, Fei Ju
OBJECTIVE: Systematic evaluation of the efficacy and safety of conservative hemodynamic cure for venous insufficiency (CHIVA) compared with high ligation and stripping (HLS) in the treatment of varicose veins of lower extremities. METHODS: We conducted a systematic literature search and compared the randomized controlled trial and retrospective cohort study of CHIVA and HLS in the treatment of varicose veins of lower extremities in several databases, including China National Knowledge Infrastructure, Wanfang database, cqvip datebase, PubMed, Cochrane library and EMBASE, to identify articles that might meet the criteria...
November 3, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37830113/a-challenging-case-of-oral-ulcers-and-gastrointestinal-bleeding-crohn-s-or-beh%C3%A3-et-s-disease
#10
Marina A S Dantas, Ana Luiza Graneiro, Rodrigo Cavalcante, Lina Maria Felipez
Introduction . Differentiating Crohn's disease (CD) and Behçet's disease (BD) with gastrointestinal (GI) manifestations can be clinically challenging, as current diagnostic criteria are not clear between both conditions and multiple symptoms could overlap. Case Presentation . The patient is an 8-year-old boy of Brazilian descent, who initially presented with a 1-year history of painful oral ulcers. Before presenting to the hospital, he had been treated for periodic fever, aphthous stomatitis, pharyngitis, and adenitis and placed on steroids, with relapsing symptoms on attempts to wean the doses...
2023: Case Reports in Pediatrics
https://read.qxmd.com/read/37794997/mesenteric-arterial-thrombosis-revealing-relapse-of-nephrotic-syndrome-in-young-women
#11
Maryem Ferjani, Yosra Zaimi, Nouha Trad, Yousra Hammi, Myriam Ayari, Shema Ayadi, Taha Sayari, Tahar Gargah
BACKGROUND: Nephrotic syndrome (NS) is associated with a hypercoagulable state and may be complicated by thrombotic events. Venous thrombosis is well-acknowledged, while arterial thrombosis is rather unusual. CASE PRESENTATION: We present the case of a 20-year-old woman with a 12-year history of idiopathic NS revealed by extensive cerebral venous thrombosis with pulmonary embolism treated with anticoagulation therapy and oral corticosteroid therapy followed by mycophenolate mofetil (MMF)...
2023: International Medical Case Reports Journal
https://read.qxmd.com/read/37791647/d-dimers-variability-in-the-perioperative-period-of-breast-cancer-surgery-helps-to-predict-cancer-relapse-a-single-centre-prospective-study
#12
JOURNAL ARTICLE
Małgorzata Dybowska, Dariusz Dybowski, Monika Szturmowicz, Adam Jóźwik, Katarzyna Lewandowska, Małgorzata Sobiecka, Witold Tomkowski
BACKGROUND: The importance of D-dimers (DD) assessment in the diagnostic algorithm of venous thromboembolic (VTE) disease is well known. Increase of DD concentration may be also associated with neoplastic disease. Many studies documented that high concentration of DD before solid tumour surgery indicates more advanced disease and poor life expectancy. The prognostic value of the DD concentration variability in the perioperative period, in women undergoing breast cancer surgery, has not been analysed so far...
2023: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/37786830/incidence-and-management-of-thromboembolism-in-patients-with-acute-leukemia
#13
JOURNAL ARTICLE
Salih Güler, Aytül Temuroğlu, Melike Sezgin Evim, Adalet Meral Günes
Thromboembolic events (TE) in childhood are relatively rare but, serious complications of acute leukemia. The aim was to define the incidence and risk factors of thrombosis in children with leukemias. The electronic files of pediatric denovo/relapsed acute leukemia patients aged below 18 years, treated between 2011 and 2021 were retrospectively evaluated for thrombotic attacks. Thirty out of 469 patients developed 35 thrombotic events. The median age at the time of the TE was 11.8 (2-17.6) years, and the median time from diagnosis to TE was 9 (0-58) months...
October 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/37775123/neurological-involvement-by-beh%C3%A3-et-s-syndrome-clinical-features-diagnosis-treatment-and-outcome
#14
REVIEW
Desmond Patrick Kidd
Neurological involvement in Behçet's syndrome arises predominately through an inflammatory meningoencephalitis characterised by perivenular inflammation due to activation of Th-17 immunological pathways. The brainstem is involved in 50% of cases, the diencephalon and other areas of the brain in 30%, and the spinal cord in 10%. Movement disorders and epilepsy may occur. Psychiatric syndromes may arise with brain and brainstem involvement, and cognitive disorders relate to the brain disease, to circulating inflammatory factors, and to fatigue and despondency...
October 2023: Practical Neurology
https://read.qxmd.com/read/37736104/relapsing-tipic-syndrome-after-administration-of-an-mrna-based-covid-19-vaccine
#15
Georgiana C Sandu, Gregor Weisser, Stefan Krämer, Matthias Reinhard
Reported vascular complications following mRNA-based COVID-19 vaccines are consisting of myocarditis, cerebral venous thrombosis, cerebral vascular thrombosis, and vaccine-induced thrombocytopenia. Here, we describe a case of a 49-year-old woman with left-sided pain above the middle common carotid artery (carotidynia) starting a few days after her second vaccination with an mRNA-based COVID-19 vaccine (Spikevax). Imaging was indicative of transient perivascular inflammation of the carotid artery (TIPIC) syndrome...
2023: Case Reports in Vascular Medicine
https://read.qxmd.com/read/37614942/acute-pulmonary-embolism-with-arrhythmia-associated-with-minimal-change-disease-in-adults-a-case-report
#16
Chunyan Rong, Xuhan Liu, Baoguo Wang, Weihua Zhang
BACKGROUND: Minimal change disease (MCD) is a common pathological type of nephrotic syndrome (NS), and is one of the most common causes of NS in children, but is not common in adults. MCD is sensitive to corticosteroid therapy and has a good prognosis, but is prone to relapse. Venous thromboembolism (VTE) is less common in MCD. CASE PRESENTATION: We report a case of acute pulmonary embolism (PE) with arrhythmia associated with MCD in adults. The hypercoagulable state caused by MCD through multiple systems may be one of the important causes of thrombosis in this patient...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37601429/relapse-of-nephrotic-syndrome-with-unusual-thromboembolic-event-a-case-report
#17
Zahra Pournasiri, Seyedeh Masumeh Hashemi, Seyyedeh Narjes Ahmadizadeh, Bahareh Yaghmaei, Mitra Khalili, Azita Behzad, Amirali Soheili, Mahnaz Jamee
KEY CLINICAL MESSAGE: Most children with nephrotic syndrome heal without any sequelae. However, rare life-threatening complications such as thromboembolism may occur in pediatric nephrotic syndrome and should be considered in those with a new-onset neurologic deficit. ABSTRACT: The thromboembolism (TE) as a complication of nephrotic syndrome (NS) is rare and serious, and may involve renal, cerebral, pulmonary, or peripheral venous and/or arterial thrombosis. Here, we describe a 4...
August 2023: Clinical Case Reports
https://read.qxmd.com/read/37583732/pulmonary-arterial-aneurysms-and-thrombosis-in-a-young-male-a-rare-presentation-of-behcet-s-disease
#18
Bapi Raju V Kurada, Chukwuemeka A Umeh, Rakesh C Gupta, Stella C Onyi, Jose Penaherrera
Behcet's disease (BD) is a chronic systemic inflammatory vasculitis with a relapsing and remitting course. The disease predominantly affects males between the ages of 20 and 40 years. The disease is more prevalent in Middle Eastern and Asian countries but is less common in North American countries. BD typically presents as recurrent oro-genital ulcers and ocular inflammation. Pulmonary vasculitis with pulmonary arterial involvement is a unique manifestation, with most pulmonary manifestations occurring later in the disease course...
July 2023: Curēus
https://read.qxmd.com/read/37534898/the-effectiveness-of-adalimumab-as-an-add-on-therapy-on-two-cases-with-leg-ulcers-in-beh%C3%A3-et-s-disease-resistant-to-conventional-immunosuppressive-therapy-alone-and-review-of-the-literature
#19
JOURNAL ARTICLE
Nedim Kaban, Halil Harman
We report two cases with leg ulcers in Behçet's disease (BD) resistant to conventional immunosuppressive therapy (CIST) alone but successfully treated with adding on adalimumab (ADA). BD, which can affect vessels of any size and type, is a systemic vasculitis. In the vascular system, veins are the most predominatly affected blood vessels with deep vein thrombosis (DVT) and recurrent superficial vein thrombophlebitis (SVT) that are the most common vascular signs of the disease in the lower extremities. Leg ulcers, commonly associated with vasculitis or deep vein thrombosis, are rare in patients with BD...
August 3, 2023: Modern rheumatology case reports
https://read.qxmd.com/read/37480098/vacuoles-e1-enzyme-x-linked-autoinflammatory-and-somatic-syndrome-in-the-intensive-care-unit-a%C3%A2-case-report
#20
JOURNAL ARTICLE
Félicie Belicard, Nicolas Belhomme, Simon Bouzy, Clémence Saillard, Fabienne Nedelec, Jean-Baptiste Mear, Samuel Ardois, Cedric Pastoret, Florian Reizine, Christophe Camus, Benoit Painvin
BACKGROUND: Vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic syndrome is a newly discovered inflammatory disease affecting male subjects, for which few data exist in the literature. Here, we describe the case of a patient with known Sweet's syndrome admitted to the intensive care unit and for whom a vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic syndrome was diagnosed, allowing for appropriate treatment and the patient's discharge and recovery. CASE PRESENTATION: A 70-year-old male White patient was hospitalized in the intensive care unit following an intrahospital cardiac arrest...
July 22, 2023: Journal of Medical Case Reports
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