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https://www.readbyqxmd.com/read/27875736/emerging-roles-and-mechanisms-of-long-noncoding-rnas-in-atherosclerosis
#1
REVIEW
Yao Liu, Lei Zheng, Qian Wang, Yan-Wei Hu
Atherosclerosis is the most common cause of heart attacks, strokes, and peripheral vascular disease. Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Increasing evidence suggests that long non-protein-coding RNAs (lncRNAs) are important for the regulation of tissue homeostasis and pathophysiological conditions. Although knowledge about lncRNAs in atherosclerosis and other cardiovascular diseases is sparse, lncRNAs are clinically interesting because of their diagnostic and therapeutic value...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27856951/lipoprotein-a-levels-and-recurrent-vascular-events-after-first-ischemic-stroke
#2
Kristin S Lange, Alexander H Nave, Thomas G Liman, Ulrike Grittner, Matthias Endres, Martin Ebinger
BACKGROUND AND PURPOSE: The association of elevated lipoprotein(a) (Lp(a)) levels and the incidence of cardiovascular disease, especially coronary heart disease and ischemic stroke, is well established. However, evidence on the association between Lp(a) levels and residual vascular risk in stroke survivors is lacking. We aimed to elucidate the risk for recurrent cardiovascular and cerebrovascular events in the patients with first-ever ischemic stroke with elevated Lp(a). METHODS: All patients with acute ischemic stroke who participated in the prospective Berlin C&S study (Cream & Sugar) between January 2009 and August 2014 with available 12-month follow-up data and stored blood samples were eligible for inclusion...
November 17, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27831848/productivity-losses-associated-with-cardiovascular-disease-a-systematic-review
#3
Adam L Gordois, Peter P Toth, Ruben Gw Quek, Emma M Proudfoot, Carly J Paoli, Shravanthi R Gandra
People with cardiovascular disease (CVD) often require time off work to recover from illness or surgery; for example, following a myocardial infarction (MI) or stroke. These individuals incur income losses, work-related productivity is reduced for employers, and output is reduced for the wider economy. Productivity impacts to the economy also arise due to CVD-related mortality. Areas covered: A systematic literature review was conducted to identify and collate studies that report the magnitude of work-related productivity losses associated with CVD generally or specific cardiovascular (CV) events or conditions (coronary heart disease, MI, stroke, transient ischemic attack, angina, heart failure, peripheral artery disease, coronary revascularization)...
December 2016: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/27825770/estimating-longitudinal-risks-and-benefits-from-cardiovascular-preventive-therapies-among-medicare-patients-the-million-hearts-longitudinal-ascvd-risk-assessment-tool
#4
Donald M Lloyd-Jones, Mark D Huffman, Kunal N Karmali, Darshak M Sanghavi, Janet S Wright, Colleen Pelser, Martha Gulati, Frederick A Masoudi, David C Goff
The Million Hearts Initiative has a goal of preventing 1 million heart attacks and strokes-the leading causes of mortality-through several public health and healthcare strategies by 2017. The American Heart Association and American College of Cardiology support the program. The Cardiovascular Risk Reduction Model was developed by Million Hearts and the Center for Medicare & Medicaid Services as a strategy to asses a value-based payment approach toward reduction in 10-year predicted risk of atherosclerotic cardiovascular disease (ASCVD) by implementing cardiovascular preventive strategies to manage the "ABCS" (aspirin therapy in appropriate patients, blood pressure control, cholesterol management, and smoking cessation)...
October 28, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27823096/mediterranean-diet-could-cut-cardiovascular-disease-risk
#5
(no author information available yet)
A diet high in fruits, vegetables, nuts and whole grains could significantly reduce risk of stroke and heart attacks, say University of Cambridge researchers.
October 5, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27821100/exploratory-study-into-the-awareness-of-heart-diseases-among-emirati-women-uae-and-their-health-seeking-behaviour-a-qualitative-study
#6
Sarah Khan, Ayesha Khoory, Dhabia Al Zaffin, Meera Al Suwaidi
BACKGROUND: Cardiovascular diseases were the leading cause of death in women in the United Arab Emirates (UAE) in 2010. The UAE is expected to experience a tripling of heart diseases in the next two decades as risk factors for heart diseases increase. Research shows that first year survival rates of younger women suffering from a heart attack are lower than in men. Women present with a wider range of symptoms for heart diseases than men; non-recognition of atypical symptoms may explain the delay in seeking treatment and poor prognosis following heart diseases in women...
November 7, 2016: BMC Women's Health
https://www.readbyqxmd.com/read/27815375/estimating-longitudinal-risks-and-benefits-from-cardiovascular-preventive-therapies-among-medicare-patients-the-million-hearts-longitudinal-ascvd-risk-assessment-tool-a-special-report-from-the-american-heart-association-and-american-college-of-cardiology
#7
Donald M Lloyd-Jones, Mark D Huffman, Kunal N Karmali, Darshak M Sanghavi, Janet S Wright, Colleen Pelser, Martha Gulati, Frederick A Masoudi, David C Goff
The Million Hearts Initiative has a goal of preventing 1 million heart attacks and strokes-the leading causes of mortality-through several public health and healthcare strategies by 2017. The American Heart Association and American College of Cardiology support the program. The Cardiovascular Risk Reduction Model was developed by Million Hearts and the Center for Medicare & Medicaid Services as a strategy to asses a value-based payment approach toward reduction in 10-year predicted risk of atherosclerotic cardiovascular disease (ASCVD) by implementing cardiovascular preventive strategies to manage the "ABCS" (aspirin therapy in appropriate patients, blood pressure control, cholesterol management, and smoking cessation)...
November 4, 2016: Circulation
https://www.readbyqxmd.com/read/27753983/sy-09-1-lowering-salt-intake-and-cardiovascular-risk-reduction-what-is-the-evidence
#8
Francesco Cappuccio
The evidence. Salt (i.e. sodium chloride) is causally related to blood pressure (BP). The higher the salt intake, the higher the BP, an effect seen since birth. A small and sustained reduction in salt intake causes a fall in BP. The evidence from controlled studies, small and large, short and long, all agree on the following: (1) salt intake is one of the major determinants of BP in populations and individuals; (2) a reduction in salt intake causes a dose-dependent reduction in BP - the lower the salt the lower the BP; (3) the effect is seen in both sexes, in people of all ages and ethnic groups, and with all starting BPs...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753865/poa-01-1-moderate-dietary-salt-reduction-in-populations
#9
Francesco Cappuccio
Current salt consumption in human societies is now much greater than needed for survival. Furthermore, high salt intake substantially increases blood pressure (BP) in both animals and humans. Conversely, a reduction in salt intake causes a dose-dependent reduction in BP in men and women of all ages and ethnic groups, and in patients already on medication. The risk of strokes and heart attacks rises with increasing BP, but can be decreased by anti-hypertensive drugs. However, the majority of cardiovascular disease (CVD) events occur in the numerous individuals with 'normal' BP levels below the 'clinically hypertensive' level which might trigger drug therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27725020/risk-of-cardiovascular-disease-among-teachers-in-cape-town-findings-of-the-south-african-pact-pilot-study
#10
E C Laurence, J Volmink, T M Esterhuizen, S Dalal, M D Holmes
BACKGROUND: The accelerating epidemic of cardiovascular disease (CVD) and other non-communicable diseases (NCDs) highlights the need to establish long-term cohort studies in Africa. OBJECTIVE: The Partnership for Cohort Research and Training (PaCT) seeks to study NCDs in South Africa (SA), Uganda, Tanzania and Nigeria on a long-term basis. Pilot studies at each site have tested feasibility. The SA site additionally studied the prevalence of CVD risk factors and categorised participants' 10-year predicted risk of a cardiovascular event...
September 23, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27643102/poa-01-1-moderate-dietary-salt-reduction-in-populations
#11
Francesco Cappuccio
Current salt consumption in human societies is now much greater than needed for survival. Furthermore, high salt intake substantially increases blood pressure (BP) in both animals and humans. Conversely, a reduction in salt intake causes a dose-dependent reduction in BP in men and women of all ages and ethnic groups, and in patients already on medication. The risk of strokes and heart attacks rises with increasing BP, but can be decreased by anti-hypertensive drugs. However, the majority of cardiovascular disease (CVD) events occur in the numerous individuals with 'normal' BP levels below the 'clinically hypertensive' level which might trigger drug therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642894/sy-09-1-lowering-salt-intake-and-cardiovascular-risk-reduction-what-is-the-evidence
#12
Francesco Cappuccio
The evidence. Salt (i.e. sodium chloride) is causally related to blood pressure (BP). The higher the salt intake, the higher the BP, an effect seen since birth. A small and sustained reduction in salt intake causes a fall in BP. The evidence from controlled studies, small and large, short and long, all agree on the following: (1) salt intake is one of the major determinants of BP in populations and individuals; (2) a reduction in salt intake causes a dose-dependent reduction in BP - the lower the salt the lower the BP; (3) the effect is seen in both sexes, in people of all ages and ethnic groups, and with all starting BPs...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27621833/low-eosinophil-and-low-lymphocyte-counts-and-the-incidence-of-12-cardiovascular-diseases-a-caliber-cohort-study
#13
Anoop Dinesh Shah, Spiros Denaxas, Owen Nicholas, Aroon D Hingorani, Harry Hemingway
BACKGROUND: Eosinophil and lymphocyte counts are commonly performed in clinical practice. Previous studies provide conflicting evidence of association with cardiovascular diseases. METHODS: We used linked primary care, hospitalisation, disease registry and mortality data in England (the CALIBER (CArdiovascular disease research using LInked Bespoke studies and Electronic health Records) programme). We included people aged 30 or older without cardiovascular disease at baseline, and used Cox models to estimate cause-specific HRs for the association of eosinophil or lymphocyte counts with the first occurrence of cardiovascular disease...
2016: Open Heart
https://www.readbyqxmd.com/read/27620069/histone-deacetylase-inhibitors-future-therapeutics-for-insulin-resistance-and-type-2-diabetes
#14
Sorabh Sharma, Rajeev Taliyan
Insulin resistance is a common feature of obesity and predisposes the affected individuals to a variety of pathologies, including type 2 diabetes mellitus (T2DM), dyslipidemias, hypertension, cardiovascular disease etc. Insulin resistance is the primary cause of T2DM and it occurs many years before the disease onset. Although Thiazolidinediones (TZDs) such as rosiglitazone and pioglitazone are outstanding insulin sensitizers and are in clinical use since 1990s, however, their serious side effects such as heart attack and bladder cancer have limited their utilization...
September 9, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27601888/factors-associated-with-lipid-goal-attainment-among-acute-coronary-syndrome-patients
#15
Siti-Zainora Mohd-Zulkefli, Marhanis-Salihah Omar, Adyani Md-Redzuan
BACKGROUND: The incidence of acute coronary syndrome (ACS), one of the most common cardiovascular diseases, is high. Lipid goal attainment is one of the important factors to reduce the risk of recurrent heart attack. Identification of factors influencing lipid goal attainment such as age, female, race, underlying comorbidities, intensity of lipid-lowering therapy, patients' knowledge, and patients' belief about medicine would be beneficial in achieving the lipid goal. This study is aimed to determine lipid profile attainment and prescribing pattern of lipid-lowering therapy as well as to identify factors influencing lipid profile attainment among ACS patients...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27571048/cpap-for-prevention-of-cardiovascular-events-in-obstructive-sleep-apnea
#16
RANDOMIZED CONTROLLED TRIAL
R Doug McEvoy, Nick A Antic, Emma Heeley, Yuanming Luo, Qiong Ou, Xilong Zhang, Olga Mediano, Rui Chen, Luciano F Drager, Zhihong Liu, Guofang Chen, Baoliang Du, Nigel McArdle, Sutapa Mukherjee, Manjari Tripathi, Laurent Billot, Qiang Li, Geraldo Lorenzi-Filho, Ferran Barbe, Susan Redline, Jiguang Wang, Hisatomi Arima, Bruce Neal, David P White, Ron R Grunstein, Nanshan Zhong, Craig S Anderson
BACKGROUND: Obstructive sleep apnea is associated with an increased risk of cardiovascular events; whether treatment with continuous positive airway pressure (CPAP) prevents major cardiovascular events is uncertain. METHODS: After a 1-week run-in period during which the participants used sham CPAP, we randomly assigned 2717 eligible adults between 45 and 75 years of age who had moderate-to-severe obstructive sleep apnea and coronary or cerebrovascular disease to receive CPAP treatment plus usual care (CPAP group) or usual care alone (usual-care group)...
September 8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27549083/salivary-and-serum-adiponectin-and-c-reactive-protein-levels-in-acute-myocardial-infarction-related-to-body-mass-index-and-oral-health
#17
J L Ebersole, R J Kryscio, C Campbell, D F Kinane, J McDevitt, N Christodoulides, P N Floriano, C S Miller
BACKGROUND AND OBJECTIVE: Adiponectin is produced by adipose cells and is considered an anti-inflammatory molecule. In contrast, C-reactive protein (CRP) has been identified as a hallmark of systemic inflammation and used as a risk marker of cardiovascular disease (CVD). Of interest was the relationship of these two biomarkers to oral health and CVD risk. MATERIAL AND METHODS: This investigation examined these two molecules in serum and unstimulated whole saliva of patients within 48 h of an acute myocardial infarction (AMI) compared to control subjects...
August 23, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27516798/thirty-year-risk-of-cardiovascular-disease-in-senior-medical-students-based-on-the-studheart-study
#18
Robert Morawiec, Kamil Janikowski, Malgorzata Lelonek
INTRODUCTION: Long-term risk functions highlight the need of prophylaxis in youth before the first symptoms of cardiovascular disease (CVD) occur. AIM: On the basis of data obtained in the StudHeart study, the aim of this report was to evaluate the 30-year risk of CVD based on the risk scale developed by the Framingham Heart Study (FHS). MATERIAL AND METHODS: Seven hundred and one students aged 22-27 (mean age: 24 ±1.42) from the 5(th) and 6(th) year of the medical faculties of the Medical University of Lodz were included in the study...
June 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/27516056/impact-of-heart-rate-on-admission-on-mortality-and-morbidity-in-acute-ischaemic-stroke-patients-results-from-vista
#19
C H Nolte, H Erdur, U Grittner, A Schneider, S K Piper, J F Scheitz, I Wellwood, P M W Bath, H-C Diener, K R Lees, M Endres
BACKGROUND AND PURPOSE: Elevated heart rate (HR) is associated with worse outcomes in patients with cardiovascular disease. Its predictive value in acute stroke patients is less well established. We investigated the effects of HR on admission in acute ischaemic stroke patients. METHODS: Using the Virtual International Stroke Trials Archive (VISTA) database, the association between HR in acute stroke patients without atrial fibrillation and the pre-defined composite end-point of (recurrent) ischaemic stroke, transient ischaemic attack (TIA), myocardial infarction (MI) and vascular death within 90 days was analysed...
December 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27491766/-alcohol-consumption-in-women-and-the-elderly-when-does-it-induce-heart-failure
#20
S Pankuweit
The association between alcohol consumption and the etiology and prognosis of cardiovascular diseases has been the focus of attention and also the subject of controversial discussions for many years. This is particularly true for heart failure, which can be induced by coronary artery disease (CAD), arterial hypertension, atrial and ventricular arrhythmias and cardiomyopathies. Acute effects of high doses of alcohol can lead to impairment of the cardiac contraction strength with rhythm disturbances (holiday heart syndrome), transient ischemic attacks and in rare cases to sudden cardiac death...
September 2016: Herz
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