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https://www.readbyqxmd.com/read/28240853/enhancement-in-sustained-release-of-antimicrobial-peptide-from-dual-diameter-structured-tio2-nanotubes-for-long-lasting-antibacteria-and-cytocompatibility
#1
Yanni Zhang, Lan Zhang, Bo Li, Yong Han
Novel films on Ti-based orthopedic implants for localized antimicrobial delivery, which comprised dual-diameter TiO2 nanotubes with the inner layers of compact and Fluorine-free oxide tightly bonding to Ti, were formed by voltage-increased anodization with F- sedimentation procedure. The nanotubes were closely aligned and structured with upper 35 and 70 nm diametric tubes as nanocaps, respectively, and the underlying 140 nm diametric tubes as nanoreservoirs. Followed by loading ponericin G1 (a kind of antimicrobial peptide (AMP)) into the dual-diameter nanotubes with vacuum-assisted physisorption, the resultant films were investigated for loading efficiency and release kinetics of AMP, antibacterial activity against Staphylococcus aureus and osteoblastic compatibility, together with the AMP loaded single-diameter (140 nm) nanotube film...
February 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28240419/enhanced-antimicrobial-effects-of-decellularized-extracellular-matrix-cormatrix-with-added-vancomycin-and-gentamicin-for-device-implant-protection
#2
Thomas F Deering, Carlos Chang, Carl Snyder, Selvamuthu K Natarajan, Robert Matheny
BACKGROUND: The incidence of cardiac implantable electronic device (CIED) infections has risen significantly over the past years. Although several devices are currently available to decrease the incidence of infection, most are made from non-viable synthetic material and are more prone to infection than vascularized tissue. OBJECTIVE: This study was undertaken to assess the resistance to infection of the CorMatrix CanGaroo, a CIED envelope made of decellularised extracellular matrix (ECM) hydrated in different antibiotic solutions...
February 27, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28238505/rapid-diagnosis-of-sexually-transmitted-infections
#3
Luis Otero-Guerra, Ana Fernández-Blázquez, Fernando Vazquez
Sexually transmitted infections (STIs) are responsible for an enormous burden of morbidity and mortality. Worldwide, millions of cases of STIs, such as syphilis, chlamydia, or gonorrhoea occur every year, and there is now an increase in antimicrobial resistance in pathogens, such as gonococcus. Delay in diagnosis is one of the factors that justifies the difficulty in controlling these infections. Rapid diagnostic tests allow the introduction of aetiological treatment at the first visit, and also leads to treating symptomatic and asymptomatic patients more effectively, as well as to interrupt the epidemiological transmission chain without delay...
February 23, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28238035/major-antimicrobial-representatives-from-marine-sponges-and-or-their-associated-bacteria
#4
Fei He, Linh H Mai, Johan Gardères, Amjad Hussain, Vesna Erakovic Haber, Marie-Lise Bourguet-Kondracki
The rapid emergence of resistant bacteria during the last 20 years has stimulated research efforts in order to overcome this thorny problem. Marine sponges and their associated bacteria, which have been proven to be a source of bioactive natural products, have appeared as a promising opportunity to identify new antibiotic compounds. An overview of the major antibacterial compounds isolated from marine sponges and/or their associated bacteria is presented in this chapter, highlighting new potential antibiotics...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28237766/n-acetylcysteine-inhibits-growth-adhesion-and-biofilm-formation-of-gram-positive-skin-pathogens
#5
Daria Eroshenko, Tatyana Polyudova, Vladimir Korobov
N-Acetylcysteine (NAC) is a non-antibiotic drug with antimicrobial properties against biofilm phenotypes of Gram-positive and Gram-negative bacteria. Our aim was to assess the effects of NAC on the growth of Gram-positive human skin and mucous membrane pathogens in the planktonic and biofilm phases. The minimum inhibitory concentrations (MICs) of NAC against Enterococcus faecalis, Corynebacterium ammoniagenes, Mycobacterium smegmatis, Propionibacterium acnes, Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes, and 14 clinical strains of coagulase-negative staphylococci (CNS) ranged from 0...
February 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28237599/prevalence-antimicrobial-resistance-and-molecular-characterization-of-campylobacter-spp-in-bulk-tank-milk-and-milk-filters-from-us-dairies
#6
Laura P Del Collo, Jeffrey S Karns, Debabrata Biswas, Jason E Lombard, Bradd J Haley, R Camilla Kristensen, Christine A Kopral, Charles P Fossler, Jo Ann S Van Kessel
Campylobacter spp. are frequently isolated from dairy cows as commensal organisms. Sporadic Campylobacter infections in humans in the United States are generally attributed to poultry, but outbreaks are also commonly associated with dairy products, particularly unpasteurized or raw milk. Bulk tank milk samples and milk filters from US dairy operations were collected during the National Animal Health Monitoring System Dairy 2014 study and analyzed using real-time PCR and traditional culture techniques for the presence of thermophilic Campylobacter species...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28237557/synthesis-of-1-3-5-trisubstituted-pyrazolines-as-potential-antimalarial-and-antimicrobial-agents
#7
Vikash K Mishra, Mitali Mishra, Varsha Kashaw, Sushil K Kashaw
A series of novel 1,3,5-trisubstituted pyrazolines derivatives have been synthesized from chalcones and nicotinic acid hydrazide in two steps. In first step, chalcones were prepared by treatment of 4-hydroxy acetophenone with different substituted benzaldehyde by Claisen-Schimidt Condensation. In second step, various pyrazoline derivatives were prepared by reflux reaction of chalcones with nicotinic acid hydrazide in ethanolic solution. Compounds were confirmed by elemental analyses, IR, (1)H NMR and (13)C NMR spectral data and were evaluated for antimalarial and antibacterial activity...
February 14, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28236646/an-invertebrate-sting-from-shrimp-activates-an-innate-immune-defense-against-bacterial-infection
#8
Haoyang Li, Sheng Wang, Kai Lǚ, Bin Yin, Bang Xiao, Sedong Li, Jianguo He, Chaozheng Li
It has been proposed that invertebrate stimulators of interferon genes (STINGs) do not take part in the innate immune response to infection. Herein, we identified a new STING homolog from pacific white shrimp Litopenaeus vannamei (LvSTING). Some amino acids crucial for recognizing cyclic dinucleotides in mammals are highly conserved in LvSTING. Moreover, LvSTING expression can be robustly induced by challenge with the Gram-negative bacteria Vibrio parahaemolyticus. Silencing of LvSTING contributes to decreased expression of the antimicrobial peptide PEN4 and renders shrimp more susceptible to V...
February 25, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28236643/selection-of-indigenous-lactobacillus-paracasei-cd4-and-lactobacillus-gastricus-btm-7-as-probiotic-assessment-of-traits-combined-with-principal-component-analysis
#9
Kavita Sharma, Rishi Mahajan, Sampan Attri, Gunjan Goel
AIMS: The population of Himalayan region is known to consume variety of fermented and non fermented foods and as a result they have been benefited in terms of overall health, because of the associated beneficial microbes. Therefore, the focus of the present study was to identify new strains of Lactic Acid Bacteria (LAB) from dairy products such as milk (cow, goat, buffalo) and fermented products (curd and buttermilk) with properties suitable for use as probiotic cultures. METHODS AND RESULTS: A total of 75 isolates tentatively identified as LAB from 100 samples were initially screened for production of β-hemolysin as indicators of virulence which resulted in 38 isolates with no haemolytic activity...
February 25, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28236620/influence-of-huang-lian-jie-du-decoction-on-quorum-sensing-system-of-pseudomonas-aeruginosa
#10
Fei Xia, Lihua Ye, Ping Wang, Mingwei Zhang
Context • Pseudomonas aeruginosa (P aeruginosa) is an opportunistic and nosocomial, Gram-negative pathogen that is characteristic of quorum sensing (QS) modulation. QS inhibition (QSI) is considered to be a new approach to antimicrobial treatment that may reduce issues of antibiotic resistance. Traditional Chinese herbs have been recognized as a source of QSI. Objective • This study was intended to investigate whether the Huang Lian Jie Du decoction (HLJJD) possesses the ability to produce anti-QS activity...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236177/virulence-genes-and-antimicrobial-susceptibility-of-lactose-negative-and-lactose-positive-strains-of-escherichia-coli-isolated-from-pregnant-women-and-neonates
#11
Agnieszka Kaczmarek, Krzysztof Skowron, Anna Budzyńska, Katarzyna Grudlewska, Eugenia Gospodarek-Komkowska
Escherichia coli can cause serious infections in the neonates and pregnant women. Although E. coli is widely studied, E. coli lactose-negative (lac-) strains have been rarely described before. So, the aim of this study was to compare lac- and lactose-positive (lac+) E. coli strains in respect of antimicrobial susceptibility and the frequency of virulence genes (VGs). The study included 58 lac+ and 58 lac- E. coli strains isolated from pregnant women and neonates. Culture and the results of biochemical reactions were conducted for lac- and lac+ E...
February 24, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28235706/the-lytic-activity-of-recombinant-phage-lysin-lysk%C3%AE-amidase-against-staphylococcal-strains-associated-with-bovine-and-human-infections-in-the-jiangsu-province-of-china
#12
Yan Zhou, Hui Zhang, Hongduo Bao, Xiaomeng Wang, Ran Wang
We investigated the lytic activity of the bacteriophage endolysin (lysin) LysKΔamidase against live methicillin-resistant and-susceptible staphylococcal strains clinically isolated from bovine milk and humans from different origins of China. Antibiotic resistance patterns, multilocus sequence typing and SCCmec type of 137 staphylococcal strains isolated from bovine milk associated with bovine mastitis and human diseases were studied. A lytic enzyme, LysKΔamidase, was constructed by fusing the N-terminal 220 amino acids with the C-terminal 105 amino acids of staphylococcal phage lysin LysK...
February 16, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28235571/efficacy-of-rifampicin-combination-therapy-for-the-treatment-of-enterococcal-infections-assessed-in-vivo-using-a-galleria-mellonella-infection-model
#13
Kirsty Skinner, Jonathan A T Sandoe, Ranjith Rajendran, Gordon Ramage, Sue Lang
Enterococci are a leading cause of healthcare-associated infection worldwide and display increasing levels of resistance to many of the commonly used antimicrobials, making treatment of their infections challenging. Combinations of antibiotics are occasionally employed to treat serious infections, allowing for the possibility of synergistic killing. The aim of this study was to evaluate the effects of different antibacterial combinations against enterococcal isolates using an in vitro approach and an in vivo Galleria mellonella infection model...
February 21, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28231617/characterization-of-staphylococcus-epidermidis-strains-isolated-from-industrial-cleanrooms-under-regular-routine-disinfection
#14
U Ribič, A Klančnik, B Jeršek
AIMS: The purpose of this study was the genotypic and phenotypic characterization of 57 strains of Staphylococcus epidermidis isolated from cleanroom environments, based on their biofilm formation and antimicrobial resistance profiles. METHODS AND RESULTS: Biofilm formation was investigated using real-time PCR (icaA, aap, bhp genes), the Congo red agar method, and the crystal violet assay. The majority of the strains (59.7%; 34/57) did not form biofilms according to the crystal violet assay, although the biofilm-associated genes were present in 94...
February 23, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28231455/synthetic-investigation-physicochemical-characterization-and-antibacterial-evaluation-of-ternary-bi-iii-systems-with-hydroxycarboxylic-acid-and-aromatic-chelator-substrates
#15
C M Nday, E Halevas, A Tsiaprazi-Stamou, D Eleftheriadou, A Hatzidimitriou, G Jackson, D Reid, A Salifoglou
Due to its physical and chemical properties, bismuth (Bi(III)) is widely used in the treatment of several gastrointestinal and skin diseases, and infections caused by bacteria. Herein, its known antimicrobial potential was taken into consideration in the synthesis of two new hybrid ternary materials of Bi(III) with the physiological α-hydroxycarboxylic glycolic acid and 1,10-phenanthroline (phen), [Bi2(C2H2O3)2(C2H3O3)(NO3)]n(.) nH2O (1) and [Bi(C12H8N2)(NO3)4](C10H8N4) (2), aiming at improving its antibacterial properties...
February 11, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28230992/novel-design-of-heptad-amphiphiles-to-enhance-cell-selectivity-salt-resistance-anti-biofilm-properties-and-their-membrane-disruptive-mechanism
#16
Xiujing Dou, Xin Zhu, Jiajun Wang, Na Dong, Anshan Shan
Coiled-coil, a basic folding pattern of native proteins, was previously demonstrated to be associated with the specific spatial recognition, association, and dissociation of proteins and can be used to perfect engineering peptide model. Thus, in this study, a series of amphiphiles composed of heptads repeats with coiled-coil structures was constructed, and the designed peptides exhibited a broad spectrum of antimicrobial activities. Circular dichroism and biological assays showed that the heptad repeats and length of the linker between the heptads largely influenced the amphiphile's helical propensity and cell selectivity...
February 23, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28230084/highly-potent-antimicrobial-peptides-from-n-terminal-membrane-binding-region-of-e-coli-mreb
#17
Karabi Saikia, Yalavarthi Durga Sravani, Vibin Ramakrishnan, Nitin Chaudhary
Microbial pathogenesis is a serious health concern. The threat escalates as the existing conventional antimicrobials are losing their efficacy against the evolving pathogens. Peptides hold promise to be developed into next-generation antibiotics. Antimicrobial peptides adopt amphipathic structures that could selectively bind to and disrupt the microbial membranes. Interaction of proteins with membranes is central to all living systems and we reasoned that the membrane-binding domains in microbial proteins could be developed into efficient antimicrobials...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229435/design-and-pharmacodynamics-of-recombinant-nz2114-histidine-mutants-with-improved-activity-against-methicillin-resistant-staphylococcus-aureus
#18
Huixian Chen, Ruoyu Mao, Da Teng, Xiumin Wang, Ya Hao, Xingjun Feng, Jianhua Wang
NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus. Our objective was to identify NZ2114 derivatives with improved activity through substitution of His16 and His18 with residues Arginine and Lysine. Eight mutants were designed and expressed in Pichia pastoris X-33 via pPICZαA. Five of them exhibited strong antimicrobial activity against S. aureus at low minimal inhibitory concentrations (MICs) of 0.057-0.454 μM. Among them, H1, H2, and H3 showed ideal pharmacodynamic effects on methicillin-resistant S...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28229018/-genomic-data-mining-of-the-marine-actinobacteria-streptomyces-sp-h-kf8-unveils-insights-into-multi-stress-related-genes-and-metabolic-pathways-involved-in-antimicrobial-synthesis
#19
Agustina Undabarrena, Juan A Ugalde, Michael Seeger, Beatriz Cámara
Streptomyces sp. H-KF8 is an actinobacterial strain isolated from marine sediments of a Chilean Patagonian fjord. Morphological characterization together with antibacterial activity was assessed in various culture media, revealing a carbon-source dependent activity mainly against Gram-positive bacteria (S. aureus and L. monocytogenes). Genome mining of this antibacterial-producing bacterium revealed the presence of 26 biosynthetic gene clusters (BGCs) for secondary metabolites, where among them, 81% have low similarities with known BGCs...
2017: PeerJ
https://www.readbyqxmd.com/read/28228492/neisseria-gonorrhoeae-sequence-typing-for-antimicrobial-resistance-ng-star-a-novel-antimicrobial-resistance-multilocus-typing-scheme-for-tracking-the-global-dissemination-of-n-gonorrhoeae-strains
#20
W Demczuk, S Sidhu, M Unemo, D M Whiley, V G Allen, J R Dillon, M Cole, C Seah, E Trembizki, D L Trees, E N Kersh, A J Abrams, H J C de Vries, A P van Dam, I Medina, A Bharat, M R Mulvey, G Van Domselaar, I Martin
A curated web-based user-friendly sequence typing tool based on antimicrobial resistance determinants in Neisseria gonorrhoeae was developed and is publicly accessible at https://ngstar.canada.ca The N. gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) molecular typing scheme uses the DNA sequences of 7 genes (penA, mtrR, porB, ponA, gyrA, parC, 23S rRNA) associated with resistance to β-lactam antimicrobials, macrolides, or fluoroquinolones. NG-STAR uses the entire penA sequence combining the historical nomenclature for penA types I-XXXVIII with novel nucleotide sequence designations; the full mtrR sequence and a portion of its promoter region; portions of ponA, porB, gyrA and parC; and 23S rRNA sequences...
February 22, 2017: Journal of Clinical Microbiology
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