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JOURNAL ARTICLE
Zaw Thet, Alfred King-Yin Lam, Shu-Kay Ng, Soe Yu Aung, Thin Han, Dwarakanathan Ranganathan, Stephanie Newsham, Jennifer Borg, Christine Pepito, Tien K Khoo
INTROUDCTION: There is increased risk of skin cancer in patients with gloermular disease or those with renal transplant. OBJECTIVES: To compare the risk of skin cancer between kidney recipients (KTRs) and patients with glomerular disease (GD). DESIGN: The cohort comprised patients with KTRs (n = 61) and GD (n = 51) in Central and Central West Queensland, Australia. A quantitative cohort study was undertaken to study the risk of skin cancer in rural communities between two subgroups of patients with kidney diseases in relationship to immunosuppression...
April 2024: Australian Journal of Rural Health
#2
JOURNAL ARTICLE
Yashaswinii Polaka, Evangeline P Christina, Karthik Krishna Ramakrishnan, Arunkumar Mohanakrishnan, Paarthipan Natarajan
Background Renal insufficiency, a critical concern in native and transplant kidneys, necessitates effective screening modalities for evaluation and management. Grayscale sonography has been a cornerstone in renal diagnostics, providing basic anatomical insights such as renal length, cortical thickness, and collecting system dilatation. Despite technological advancements, its impact on the differential diagnosis or management of renal disease remains limited, often showing normal findings in the presence of severe renal dysfunction...
March 2024: Curēus
#3
JOURNAL ARTICLE
Louise Moore, Frances Balmer, Alexander Woywodt
No abstract text is available yet for this article.
March 2024: Future Healthcare Journal
#4
JOURNAL ARTICLE
Nikita Pawar, Vaibhav Tiwari, Anurag Gupta, Smita Divyaveer, Imran Rather, Shiv Chadha, Vinant Bhargava, Manish Malik, Ashwani Gupta, Anil Kumar Bhalla, D S Rana, Pallav Gupta
INTRODUCTION: In view of ever-increasing end-stage renal disease (ESRD) population but inadequate availability of suitable donors, ABO-incompatible (ABOi) transplantation can be an important void filler. However, at present, ABOi transplantation is limited to a few centers in India and there is a lack of adequate experience and expertise to guide this program to other centers in the country. METHODS: Data of all the ABOi transplants performed from 2012 to 2021 in a tertiary care hospital was retrospectively analyzed...
2024: Indian Journal of Nephrology
#5
JOURNAL ARTICLE
Shalini Santhakumaran, Louis Fisher, Bang Zheng, Viyaasan Mahalingasivam, Lucy Plumb, Edward Pk Parker, Retha Steenkamp, Caroline Morton, Amir Mehrkar, Sebastian Bacon, Sue Lyon, Rob Konstant-Hambling, Ben Goldacre, Brian MacKenna, Laurie A Tomlinson, Dorothea Nitsch
OBJECTIVE: To validate primary and secondary care codes in electronic health records to identify people receiving chronic kidney replacement therapy based on gold standard registry data. DESIGN: Validation study using data from OpenSAFELY and the UK Renal Registry, with the approval of NHS England. SETTING: Primary and secondary care electronic health records from people registered at 45% of general practices in England on 1 January 2020, linked to data from the UK Renal Registry (UKRR) within the OpenSAFELY-TPP platform, part of the NHS England OpenSAFELY covid-19 service...
2024: BMJ Med
#6
EDITORIAL
Giorgina Barbara Piccoli
No abstract text is available yet for this article.
April 20, 2024: Journal of Nephrology
#7
JOURNAL ARTICLE
Rita Quinteira, Sara Gimondi, Nelson O Monteiro, Rita Sobreiro-Almeida, Laura Lasagni, Paola Romagnani, Nuno M Neves
Kidney regeneration is hindered by the limited pool of intrinsic reparative cells. Advanced therapies targeting renal regeneration have the potential to alleviate the clinical and financial burdens associated with kidney disease. Delivery systems for cells, extracellular vesicles, or growth factors aimed at enhancing regeneration can benefit from vehicles enabling targeted delivery and controlled release. Hydrogels, optimized to carry biological cargo while promoting regeneration, have emerged as promising candidates for this purpose...
April 18, 2024: Acta Biomaterialia
#8
JOURNAL ARTICLE
Claudio Carmine Guida, Angela Maria Pellegrino, Aurora Del Mar Perez Ys, Filippo Aucella
No abstract text is available yet for this article.
April 20, 2024: Journal of Nephrology
#9
JOURNAL ARTICLE
Alessandra Palmisano, Marta D'Angelo, Ilaria Gandolfini, Marco Delsante, Giovanni Maria Rossi, Micaela Gentile, Enrico Fiaccadori, Paolo Cravedi, Umberto Maggiore
INTRODUCTION: It is unclear whether kidney transplant recipients with a biopsy diagnosis as a "borderline" acute T-cell mediated rejection (TCMR) requires the treatment with intravenous (iv) steroids pulse plus/minus intensification of the maintenance therapy (TRT) in comparison with the simple clinical follow-up (F-UP). METHODS: We retrospectively followed a consecutive series of kidney transplant recipients diagnosed with a borderline acute TCMR at biopsy by surveillance or clinical indication for 12 months and compared TRT and F-UP groups...
April 17, 2024: Transplant Immunology
#10
JOURNAL ARTICLE
Penina Dienstag, Rana Halsa, Keren Tzukert, Ashraf Imam, Abed Khalaileh, Aryeh Dienstag
Living donor kidney transplantation (LDKT) is one of the most effective treatment options for people suffering from end stage renal disease. Traditionally, LDKT can be either: "directed" or "non-directed," based on whether the recipient is specified by the donor. Recently there has been an increase in conditional and semidirected live kidney donation among strangers; where the donor specifies characteristics of the recipient whom they wish to donate to. This practice has both gained popularity and sparked controversy in the State of Israel through the non-profit organization Matnat Chaim...
April 17, 2024: American Journal of Transplantation
#11
JOURNAL ARTICLE
Rajesh Nachiappa Ganesh, Edward A Graviss, Duc Nguyen, Ziad El-Zaatari, Lillian Gaber, Roberto Barrios, Luan Truong, Alton B Farris
INTRODUCTION: Semi-quantitative scoring of various parameters in renal biopsy is accepted as an important tool to assess disease activity and prognostication. There are concerns on the impact of inter-observer variability in its prognostic utility, generating a need for computerized quantification. METHODS: We studied 94 patients with renal biopsies, 45 with native diseases and 49 transplant patients with index biopsies for Polyomavirus nephropathy. Chronicity scores were evaluated using two methods...
April 17, 2024: Human Pathology
#12
Sreshta Paranji, Amir Steinberg
Post-transplant lymphoproliferative disorder (PTLD) is a condition that is highly variable in presentation but life-threatening for post-transplant, immunosuppressed patients. Current standard management in PTLD sees the use of a chemoimmunotherapy regimen similar to the management of diffuse large B-cell lymphoma. Here, we discuss the case of a 33-year-old male with a history of renal transplant, hemodynamically stable, who presented with fevers and night sweats lasting one month. Investigations revealed multiple masses in his liver, the largest of which was biopsied and revealed diffuse large B-cell lymphoma...
March 2024: Curēus
#13
REVIEW
Olga Balafa, Beatriz Fernandez-Fernandez, Alberto Ortiz, Evangelia Dounousi, Robert Ekart, Charles J Ferro, Patrick B Mark, Jose M Valdivielso, Lucia Del Vecchio, Francesca Mallamaci
Sex (biologically determined) and gender (socially constructed) modulate manifestations and prognosis of a vast number of diseases, including cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD remains the leading cause of death in CKD patients. Population-based studies indicate that women present a higher prevalence of CKD and experience less CVD than men in all CKD stages, although this is not as clear in patients on dialysis or transplantation. When compared to the general population of the same sex, CKD has a more negative impact on women on kidney replacement therapy...
March 2024: Clinical Kidney Journal
#14
JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
#15
JOURNAL ARTICLE
Melissa Rau, Adrian Santelli, Sara Martí, María Isabel Díaz, Nuria Sabé, María Fiol, Luis Riera, Begoña Etcheverry, Sergi Codina, Ana Coloma, Anna Carreras-Salinas, Carmen Ardanuy, Josep M Cruzado, Edoardo Melilli
BACKGROUND: Studies analyzing non-antibiotic alternatives in kidney transplant UTI's are lacking. d-Mannose, a simple sugar, inhibits bacterial attachment to the urothelium, as does Proanthocyanidins; both could act as a synergic strategy preventing UTI; nonetheless their efficacy and safety have not been evaluated in kidney transplant population yet. METHODS: This is a pilot prospective, double-blind randomized trial. Sixty de novo kidney transplant recipients were randomized (1:1) to receive a prophylactic strategy based on a 24-h prolonged release formulation of d-Mannose plus Proanthocyanidins vs...
April 17, 2024: Nefrología
#16
JOURNAL ARTICLE
Miko Yu, Kristen L King, Lindsey M Maclay, S Ali Husain, Jesse D Schold, Sumit Mohan
Administrative claims data could provide a unique opportunity to identify acute rejection events by use of specific anti-rejection medications and validate rejection data reported to the Organ Procurement Transplant Network (OPTN). This retrospective cohort study examined differences in registry-reported events and those identified via claims data among adult kidney transplant recipients from 2012-2017 using Standard Analysis Files from the United States Renal Data System. Rejection rates, survival estimates, and center-level differences were assessed using each approach...
April 16, 2024: American Journal of Transplantation
#17
JOURNAL ARTICLE
Tung-Ling Chung, Nai-Ching Chen, Chun-Hao Yin, Ching-Chih Lee, Chien-Liang Chen
BACKGROUND: Conflicting evidence exists regarding the relationship between socioeconomic status and access to or outcomes after kidney transplantation. This study analyzed the effects of individual and neighborhood socioeconomic status on kidney transplant access and outcomes in Taiwan. METHODS: We used a retrospective cohort study design and performed comparisons using the Cox proportional hazards model after adjusting for risk factors. Data were collected from the National Health Insurance Bureau of Taiwan data (2003-2012)...
April 18, 2024: Journal of Nephrology
#18
JOURNAL ARTICLE
Bochuan Deng, Jiao Zhang, Xiang Zhang, Dan Wang, Lu Cheng, Ping Su, Tingli Yu, Guangjun Bao, Guofeng Li, Liang Hong, Xiaokang Miao, Wenle Yang, Rui Wang, Junqiu Xie
Renal fibrosis is a complex pathological process that contributes to the development of chronic kidney disease due to various risk factors. Conservative treatment to curb progression without dialysis or renal transplantation is widely applicable, but its effectiveness is limited. Here, the inhibitory effect of the novel peptide DR3penA (DHα-(4-pentenyl)-AlaNPQIR-NH2 ), which was developed by our group, on renal fibrosis was assessed in cells and mice with established fibrosis and fibrosis triggered by transforming growth factor-β1 (TGF-β1), unilateral ureteral obstruction, and repeated low-dose cisplatin...
April 12, 2024: ACS Pharmacology & Translational Science
#19
JOURNAL ARTICLE
Wenxiang Feng, Nan Zhu, Yubin Xia, Zehai Huang, Jianmin Hu, Zefeng Guo, Yuzhuz Li, Song Zhou, Yongguang Liu, Ding Liu
Kidney transplantation is essential for patients with end-stage renal disease; however, ischemia-reperfusion injury (IRI) during transplantation can lead to acute kidney damage and compromise survival. Recent studies have reported that antiferroptotic agents may be a potential therapeutic strategy, by reducing production of reactive oxygen species (ROS). Therefore, we constructed rutin-loaded polydopamine nanoparticles (PEG-PDA@rutin NPs, referred to as PPR NPs) to eliminate ROS resulting from IRI. Physicochemical characterization showed that the PPR NPs were ∼100 nm spherical particles with good ROS scavenging ability...
April 19, 2024: IScience
#20
JOURNAL ARTICLE
Steve Biko Tobada, Valérie Chatelet, Clemence Bechade, Antoine Lanot, Annabel Boyer, Cécile Couchoud, Fatouma Toure, Sabrina Boime, Thierry Lobbedez, Mathilde Beaumier
BACKGROUND: Social deprivation is associated with lower peritoneal dialysis (PD) uptake. This study was carried out to evaluate the role of social deprivation on the outcome of PD. METHODS: This was a retrospective study of data extracted from the Renal Epidemiology and Information Network registry for patients older than 18 years who started PD in metropolitan France between 1 January 2017 and 30 June 2018. The end of the observation period was 31 December 2020...
April 17, 2024: Peritoneal Dialysis International
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