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https://www.readbyqxmd.com/read/29352743/co-transplantation-of-adipose-tissue-derived-stromal-cells-and-olfactory-ensheathing-cells-for-spinal-cord-injury-repair
#1
Eduardo D Gomes, Sofia S Mendes, Rita C Assunção-Silva, Fábio G Teixeira, Ana O Pires, Sandra I Anjo, Bruno Manadas, Hugo Leite-Almeida, Jeffrey M Gimble, Nuno Sousa, Angelo C Lepore, Nuno A Silva, António J Salgado
Patients suffering from Spinal Cord Injury (SCI) still have a dismal prognosis. Despite all the efforts developed in this area, currently there are no effective treatments. Therefore, cell therapies have been proposed as a viable alternative to the current treatments employed. Adipose tissue-derived Stem Cells (ASCs) and Olfactory Ensheathing Cells (OECs) have been used with promising results in different models of SCI, namely due to the regenerative properties of the secretome of the first, and the guidance capability of the second...
January 20, 2018: Stem Cells
https://www.readbyqxmd.com/read/29352594/systematic-review-of-uterine-artery-embolisation-practice-guidelines-are-all-the-guidelines-on-the-same-page
#2
H T Chen, S Athreya
AIM: To evaluate the degree of concordance amongst the currently available guidelines informing the use of uterine artery embolisation (UAE), and identify any inconsistencies present. MATERIALS AND METHODS: Standards of practice and quality improvement guidelines were retrieved through a search of PubMed and EMBASE. Additional sets of guidelines were retrieved directly from the websites of known obstetrics and gynaecology and radiological associations. RESULTS: Eleven guidelines were retrieved from organisations located in Europe, North America, and Australia...
January 15, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29352368/endocrine-therapy-and-related-issues-in-hormone-receptor-positive-early-breast-cancer-a-roundtable-discussion-by-the-breast-cancer-therapy-expert-group-bcteg
#3
REVIEW
Jame Abraham, Humberto Caldera, Robert Coleman, Anthony Elias, Matthew P Goetz, Muaiad Kittaneh, Elyse Lower, Reshma Mahtani, E Terry Mamounas, Mark Pegram, Hope Rugo, Lee Schwartzberg, Tiffany Traina, Chuck Vogel
PURPOSE: Management of breast cancer is a rapidly evolving field, and, although evidence-based guidelines are available for clinicians to provide direction on critical issues in patient care, clinicians often left to address these issues in the context of community practice situations with their patients. These include the patient's comorbid conditions, actual versus perceived benefit of treatments, patient's compliance as well as financial/reimbursement issues, and long-term tolerability of therapy...
January 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29351997/spatiotemporal-organization-of-exocytosis-emerges-during-neuronal-shape-change
#4
Fabio L Urbina, Shawn M Gomez, Stephanie L Gupton
Neurite elongation and branching in developing neurons requires plasmalemma expansion, hypothesized to occur primarily via exocytosis. We posited that exocytosis in developing neurons and nonneuronal cells would exhibit distinct spatiotemporal organization. We exploited total internal reflection fluorescence microscopy to image vesicle-associated membrane protein (VAMP)-pHluorin-mediated exocytosis in mouse embryonic cortical neurons and interphase melanoma cells, and developed computer-vision software and statistical tools to uncover spatiotemporal aspects of exocytosis...
January 19, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29351811/rate-and-determinants-of-non-adherence-to-a-gluten-free-diet-and-nutritional-status-assessment-in-children-and-adolescents-with-celiac-disease-in-a-tertiary-brazilian-referral-center-a-cross-sectional-and-retrospective-study
#5
Maraci Rodrigues, Glauce Hiromi Yonaminez, Carla Aline Satiro
BACKGROUND: Compliance with a gluten-free diet (GFD) is difficult at all ages but particularly for teenagers due to social, cultural, economic, and practical pressures. The multidisciplinary team responsible for the treatment of patients with celiac disease and give support to their parents plays a special role on strengthening GFD and assessing the nutritional and physical health. METHODS: A cross-sectional and retrospective study including patients under 20 years of age, with biopsy-confirmed CD, followed regularly at the Department of Pediatrics, Division of Gastroenterology, Hospital das Clínicas, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil, were surveyed using a questionnaire and serologic test applied between November 2011 and February 2012...
January 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29351792/successful-recruitment-to-trials-findings-from-the-scimitar-trial
#6
Emily Peckham, Catherine Arundel, Della Bailey, Tracy Callen, Christina Cusack, Suzanne Crosland, Penny Foster, Hannah Herlihy, James Hope, Suzy Ker, Tayla McCloud, Crystal-Bella Romain-Hooper, Alison Stribling, Peter Phiri, Ellen Tait, Simon Gilbody
BACKGROUND: Randomised controlled trials (RCT) can struggle to recruit to target on time. This is especially the case with hard to reach populations such as those with severe mental ill health. The SCIMITAR+ trial, a trial of a bespoke smoking cessation intervention for people with severe mental ill health achieved their recruitment ahead of time and target. This article reports strategies that helped us to achieve this with the aim of aiding others recruiting from similar populations...
January 19, 2018: Trials
https://www.readbyqxmd.com/read/29351710/-implementation-of-an-internet-based-self-help-for-patients-waiting-for-outpatient-psychotherapy-first-results
#7
Kristina Fuhr, Bettina Fahse, Martin Hautzinger, Marco Daniel Gulewitsch
INTRODUCTION: Numerous studies prove the efficacy of internet-based self-help programs, but integration into the health-care system was rarely investigated. The present study addresses the implementation of an internet-based self-help program into routine care of patients with depressive symptoms waiting for psychotherapy at the university outpatient center. MATERIAL AND METHODS: Patients waiting for outpatient psychotherapy were randomly assigned to either a control group or an intervention group that received access to the internet-based program Deprexis during the waiting period...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29350758/obesity-and-pediatric-drug-development
#8
Janelle D Vaughns, Laurie S Conklin, Ying Long, Panli Zheng, Fahim Faruque, Dionna J Green, John N van den Anker, Gilbert J Burckart
There is a lack of dosing guidelines for use in obese children. Moreover, the impact of obesity on drug safety and clinical outcomes is poorly defined. The paucity of information needed for the safe and effective use of drugs in obese patients remains a problem, even after drug approval. To assess the current incorporation of obesity as a covariate in pediatric drug development, the pediatric medical and clinical pharmacology reviews under the Food and Drug Administration (FDA) Amendments Act of 2007 and the FDA Safety and Innovation Act (FDASIA) of 2012 were reviewed for obesity studies...
January 19, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29350729/in-situ-mechanical-resonance-behaviour-of-pristine-and-defective-zinc-blende-gaas-nanowires
#9
Edmund Pickering, Arixin Bo, Haifei Zhan, Xiaozhou Liao, Hark Hoe Tan, YuanTong Gu
The structural versatility of semiconducting gallium arsenide (GaAs) nanowires (NWs) provides an exciting direction for the engineering of their mechanical and dynamic properties. However, the dynamic behaviour of GaAs NWs remains unexplored. In this study, comprehensive in situ mechanical resonance tests were conducted to explore the dynamic behaviour of pristine and defective zinc blende GaAs NWs. The effects of stacking faults (SFs), amorphous shell, NW tapering and end-mass particles were investigated. The quality factors (QFs) of the GaAs NWs were found to be predominately governed by surface effects, which increased linearly with the volume to surface area ratio...
January 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29350584/developing-standard-operating-procedures-for-gene-drive-research-in-disease-vector-mosquitoes
#10
Zach N Adelman, David Pledger, Kevin M Myles
The biosafety landscape for studies involving gene drive in arthropods is at a critical juncture. Numerous arthropod species represent potential targets for gene-drive-based population suppression or replacement, due to the large number of arthropods that transmit diseases, damage crops, or act as deleterious invasive species. Containment measures for gene drive research in arthropods have been discussed in the literature, but the importance of developing safe and effective standard operating procedures (SOPs) for these types of experiments has not been adequately addressed...
January 19, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29350579/evaluation-of-respiratory-motion-corrected-cone-beam-ct-at-end-expiration-in-abdominal-radiotherapy-sites-a-prospective-study
#11
Russell E Kincaid, Agung E Hertanto, Yu-Chi Hu, Abraham J Wu, Karyn A Goodman, Hai D Pham, Ellen D Yorke, Qinghui Zhang, Qing Chen, Gig S Mageras
BACKGROUND: Cone beam computed tomography (CBCT) for radiotherapy image guidance suffers from respiratory motion artifacts. This limits soft tissue visualization and localization accuracy, particularly in abdominal sites. We report on a prospective study of respiratory motion-corrected (RMC)-CBCT to evaluate its efficacy in localizing abdominal organs and improving soft tissue visibility at end expiration. MATERIAL AND METHODS: In an IRB approved study, 11 patients with gastroesophageal junction (GEJ) cancer and five with pancreatic cancer underwent a respiration-correlated CT (4DCT), a respiration-gated CBCT (G-CBCT) near end expiration and a one-minute free-breathing CBCT scan on a single treatment day...
January 19, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29350430/on-the-impact-of-sample-size-on-lc50-estimation-in-acute-fish-toxicity-testing-is-n%C3%A2-%C3%A2-7-group-enough
#12
Greg J Carr, A John Bailer, Jane M Rawlings, Scott E Belanger
The fish acute toxicity test method is foundational to aquatic toxicity testing strategies, yet the literature lacks a concise sample size assessment. While various sources address sample size, historical precedent seems to play a larger role than objective measures. Here, a novel and comprehensive quantification of the effect of sample size on estimation of the LC50 is presented, covering a wide range of scenarios. The results put into perspective the practical differences across a range of sample sizes, from N = 5/concentration up to N = 23/concentration...
January 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29350335/tools-for-assessment-of-the-appropriateness-of-prescribing-and-association-with-patient-related-outcomes-a-systematic-review
#13
REVIEW
Nashwa Masnoon, Sepehr Shakib, Lisa Kalisch-Ellett, Gillian E Caughey
BACKGROUND: There are tools and criteria in the literature aimed at distinguishing between appropriate and inappropriate medicines use. However, many have not been externally validated with regard to patient-related outcomes, potentially limiting their use in clinical practice. OBJECTIVES: The aim of the study was to conduct a systematic review to summarise (1) available prescribing appropriateness assessment tools and criteria, and (2) their associations with patient-related outcomes (external validity)...
January 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29350282/neutrophil-chemotaxis
#14
REVIEW
Björn Petri, Maria-Jesús Sanz
Neutrophils are the primary cells recruited to inflamed sites during an innate immune response to tissue damage and/or infection. They are finely sensitive to inciting stimuli to reach in great numbers and within minutes areas of inflammation and tissue insult. For this effective response, they can detect extracellular chemical gradients and move towards higher concentrations, the so-called chemotaxis process or guided cell migration. This directed neutrophil recruitment is orchestrated by chemoattractants, a chemically diverse group of molecular guidance cues (e...
January 19, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29350192/size-dependent-young-s-modulus-in-zno-nanowires-with-strong-surface-atomic-bonds
#15
Shiwen Fan, Sheng Bi, Qikun Li, Qinglei Guo, Junshan Liu, Zhongliang Ouyang, Chengming Jiang, Jinhui Song
Mechanical properties of size-dependent nanowires are important in nano-electro-mechanical systems (NEMS), and have attracted much research interest. It is desperate to characterize the size effect of nanowires at atmosphere directly to broaden its practical application instead of in high vacuum situation as reported previously. In this study, we systematically studied the Young's modulus of vertical ZnO nanowires at atmosphere. The diameters range from 48nm to 287 nm, with resonance method by non-contact atomic force microscopy (AFM)...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29349931/biomimetic-architectures-for-peripheral-nerve-repair-a-review-of-biofabrication-strategies
#16
REVIEW
Paul A Wieringa, Ana Rita Gonçalves de Pinho, Silvestro Micera, Richard J A van Wezel, Lorenzo Moroni
Biofabrication techniques have endeavored to improve the regeneration of the peripheral nervous system (PNS), but nothing has surpassed the performance of current clinical practices. However, these current approaches have intrinsic limitations that compromise patient care. The "gold standard" autograft provides the best outcomes but requires suitable donor material, while implantable hollow nerve guide conduits (NGCs) can only repair small nerve defects. This review places emphasis on approaches that create structural cues within a hollow NGC lumen in order to match or exceed the regenerative performance of the autograft...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29349842/is-end-of-life-a-special-case-connecting-q-with-survey-methods-to-measure-societal-support-for-views-on-the-value-of-life-extending-treatments
#17
Helen Mason, Marissa Collins, Neil McHugh, Jon Godwin, Job Van Exel, Cam Donaldson, Rachel Baker
Preference elicitation studies reporting societal views on the relative value of end-of-life treatments have produced equivocal results. This paper presents an alternative method, combining Q methodology and survey techniques (Q2S) to determine the distribution of 3 viewpoints on the relative value of end-of-life treatments identified in a previous, published, phase of this work. These were Viewpoint 1, "A population perspective: value for money, no special cases"; Viewpoint 2, "Life is precious: valuing life-extension and patient choice"; and Viewpoint 3, "Valuing wider benefits and opportunity cost: the quality of life and death...
January 19, 2018: Health Economics
https://www.readbyqxmd.com/read/29349638/innovation-in-3d-echocardiographic-imaging
#18
REVIEW
Pei-Ni Jone, Nee Khoo
PURPOSE OF REVIEW: The purpose of this review is to detail three-dimensional echocardiographic (3DE) innovations in pre-surgical planning of congenital heart disease, guidance of catheter interventions such as fusion imaging, and functional assessment of patients with congenital heart disease. RECENT FINDINGS: Innovations in 3DE have helped us delineate the details of atrioventricular valve function and understand the mechanism of atrioventricular valve failure in patients with atrioventricular septal defect and single ventricle post repair...
January 19, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29349617/use-of-venovenous-ecmo-for-neonatal-and-pediatric-ecmo-a-decade-of-experience-at-a-tertiary-children-s-hospital
#19
Jennifer L Carpenter, Yangyang R Yu, Darrell L Cass, Oluyinka O Olutoye, James A Thomas, Cole Burgman, Caraciolo J Fernandes, Timothy C Lee
BACKGROUND: Advances in extracorporeal membrane oxygenation (ECMO) have led to increased use of venovenous (VV) ECMO in the pediatric population. We present the evolution and experience of pediatric VV ECMO at a tertiary care institution. METHODS: A retrospective cohort study from 01/2005 to 07/2016 was performed, comparing by cannulation mode. Survival to discharge, complications, and decannulation analyses were performed. RESULTS: In total, 160 patients (105 NICU, 55 PICU) required 13 ± 11 days of ECMO...
January 18, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29349596/concomitant-use-of-antiplatelets-and-anticoagulants-in-patients-with-coronary-heart-disease-and-atrial-fibrillation-what-do-recent-clinical-trials-teach-us
#20
REVIEW
David H Lam, Sean M Bell, Ravi S Hira
PURPOSE OF REVIEW: Coronary heart disease (CHD) and atrial fibrillation (AF) are among the most common cardiovascular diseases. A significant proportion of patients have both CHD and AF and are at increased risk for thrombotic complications. Current therapy for CHD and AF includes antiplatelet and anticoagulant medications, respectively. Patients with concurrent CHD and AF may be prescribed dual antiplatelet therapy (DAPT) in addition to anticoagulation, which increases their bleeding risk...
January 19, 2018: Current Atherosclerosis Reports
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