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https://www.readbyqxmd.com/read/29166717/-left-atrial-appendage-volume-is-a-valuable-predictor-of-atrial-fibrillation-recurrence-after-radiofrequency-catheter-ablation
#1
G A Zheng, C Y Lin, L Weng, J D Chen
Objective: To investigate the association between the left atrial appendage (LAA) volume and atrial fibrillation (AF) recurrence after radiofrequency catheter ablation. Methods: We prospectively enrolled sixty-two patients with AF (40 cases with paroxysmal AF, 22 cases with persistent AF) who successfully underwent a first AF catheter ablation and had performed contrast-enhanced cardiac computed tomography (CT) prior to the procedure to measure LAA volumes in our hospital from January 2012 to August 2015. Circumferential pulmonary vein isolation was performed under the guidance of three-dimension mapping system (CARTO system)...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166475/proposal-of-a-trigger-tool-to-assess-adverse-events-in-dental-care
#2
Claudia Dolores Trierweiler Sampaio de Oliveira Corrêa, Walter Mendes
The aim of this study was to propose a trigger tool for research of adverse events in outpatient dentistry in Brazil. The tool was elaborated in two stages: (i) to build a preliminary set of triggers, a literature review was conducted to identify the composition of trigger tools used in other areas of health and the principal adverse events found in dentistry; (ii) to validate the preliminarily constructed triggers a panel of experts was organized using the modified Delphi method. Fourteen triggers were elaborated in a tool with explicit criteria to identify potential adverse events in dental care, essential for retrospective patient chart reviews...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166418/prosthetic-rehabilitation-of-a-patient-with-rare-and-severe-enamel-renal-syndrome
#3
Cedric Mauprivez, Jean-Francois Nguyen, Muriel de la Dure-Molla, Adrien Naveau
Dental rehabilitation of acute cases of enamel renal syndrome is challenging due to the absence of clinical reports. In the present case history report, examination of an 18-year-old patient revealed a complete lack of permanent teeth, as well as irregular and swollen bone and gingival morphology. Radiographs showed multiple impacted teeth in both arches. Creating a 1.5- to 2-cm interarch space was necessary for setting complete dentures. The ideal occlusal plane was chosen by combining two techniques (cephalometric radiograph and modification of the mandibular occlusal rim according to anatomical guidelines)...
November 22, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29166310/universal-applicability-of-the-furlow-palatoplasty-resident-as-primary-surgeon-in-a-consecutive-nonselective-series
#4
Mitchell A Stotland, Thanapoom Boonipat, Cheryl M Lundgren, Esperanza Garcia Gonzalo
BACKGROUND: Questions persist regarding the general applicability of the Furlow palatoplasty technique, and thus, widespread adoption of its use has been uneven. This study describes a consecutive, nonselective series of primary Furlow palatoplasties. Highlighted is the unique fact that plastic surgical residents functioned as the primary surgeon for all steps of all procedures throughout the series. METHODS: A retrospective review was undertaken of all primary palatoplasties performed under the direction of the senior surgeon between December 2005 and April 2012...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166186/medical-device-related-pressure-injuries-to-children-in-the-intensive-care-unit
#5
Eka Widiati, Nani Nurhaeni, Dewi Gayatri
Medical devices that are attached to children put pressure on their skin or mucous membranes, and the devices can lead to injuries. The objective of this study was to determine the effectiveness of injury-prevention guidance about children who need to have medical devices attached to their bodies as part of their treatment. The research used a randomized controlled trial method, along with a cross-over design in 50 respondents with age ranges from 1 day to 18 years. The control group was treated in accordance to hospital routine, while the intervention group was given medical treatment based on Kiss and Heiler's guidelines...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29165937/-jobsharing-in-medical-hospital-care-the-experience-of-the-medical-department-of-lausanne-university-hospital
#6
Nathalie Koch, Marie Méan, Peter Vollenweider, Gérard Waeber, Jean-Blaise Wasserfallen
Job sharing is a promising way of organizing work : it allows physicians wishing to work part-time to access jobs that are usually inaccessible to them, while offering hospitals the possibility to recruit or retain qualified physicians to ensure succession planning. This article describes the advantages and the main challenges of jobsharing in a medical department. It provides concrete guidance to physicians wishing to practice it, to contribute to its dissemination. Jobsharing it is a way of organizing work that is practicable and safe in hospitals, provided that partners have compatible values and vision, respect therapeutic attitudes taken by the partner and optimally coordinate their work...
November 22, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29165815/development-and-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-analytical-method-for-the-therapeutic-drug-monitoring-of-eight-novel-anticancer-drugs
#7
M Herbrink, N de Vries, H Rosing, A D R Huitema, B Nuijen, J H M Schellens, J H Beijnen
To support therapeutic drug monitoring (TDM) of patients with cancer, a fast and accurate method for simultaneous quantification of the registered anticancer drugs afatinib, axitinib, ceritinib, crizotinib, dabrafenib, enzalutamide, regorafenib and trametinib in human plasma using liquid chromatography tandem mass spectrometry was developed and validated. Human plasma samples were collected from treated patients and stored at -20 (o) C. Analytes and internal standards (stable isotopically labeled analytes) were extracted with acetonitrile...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29165641/how-to-do-or-not-to-do-%C3%A2-measuring-health-worker-motivation-in-surveys-in-low-and-middle-income-countries
#8
J Borghi, J Lohmann, E Dale, F Meheus, J Goudge, K Oboirien, A Kuwawenaruwa
A health system's ability to deliver quality health care depends on the availability of motivated health workers, which are insufficient in many low income settings. Increasing policy and researcher attention is directed towards understanding what drives health worker motivation and how different policy interventions affect motivation, as motivation is key to performance and quality of care outcomes. As a result, there is growing interest among researchers in measuring motivation within health worker surveys...
November 20, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29165607/an-evidence-based-approach-to-pre-pregnancy-counselling-for-patients-with-systemic-lupus-erythematosus
#9
Y K Onno Teng, Edwin O W Bredewold, Ton J Rabelink, Tom W J Huizinga, H C Jeroen Eikenboom, Maarten Limper, Ruth D E Fritsch-Stork, Kitty W M Bloemenkamp, Marieke Sueters
Patients with SLE are often young females of childbearing age and a pregnancy wish in this patient group is common. However, SLE patients are at high risk for adverse pregnancy outcomes that require adequate guidance. It is widely acknowledged that pre-pregnancy counselling is the pivotal first step in the management of SLE patients with a wish to become pregnant. Next, management of these patients is usually multidisciplinary and often requires specific expertise from the different physicians involved. Very recently a EULAR recommendation was published emphasizing the need for adequate preconception counselling and risk stratification...
November 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/29165160/a-review-of-vietnam-s-healthcare-reform-through-the-direction-of-healthcare-activities-doha
#10
REVIEW
Kyoko Takashima, Koji Wada, Ton Thanh Tra, Derek R Smith
OBJECTIVE: This article provides a comprehensive review of the healthcare reform process driven by the Vietnamese Ministry of Health's Direction of Healthcare Activities (DOHA) scheme. METHODS: We reviewed policy documents relating to DOHA, along with historical literature and background information describing its formation. RESULTS: DOHA (Chỉ đạo tuyến in Vietnamese) literally means guidance line or level in English. It requires healthcare facilities at higher government administration levels to support those at lower levels (the four levels being central, provincial, district, and commune), to help lower level hospitals to provide medical services for local communities in primary care settings and reduce the number of patients in higher level (central and provincial) hospitals...
October 30, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165094/potential-risks-and-mitigation-strategies-during-the-conduct-of-a-clinical-trial-an-industry-perspective
#11
Seema Bhagat, Vaibhavi Kapatkar, Sagar Katare, Ashish Mane, Colette Pinto, Kedar Pawar, Agam Shah, Hanmant Barkate
BACKGROUND: Every phase of a clinical trial should be designed in compliance with good clinical practices by following all relevant regulatory guidelines. Patient safety, data integrity and ethics are an integral part of a successful clinical trial which must be considered. Therefore risk monitoring is an essential tool to identify the risks associated with conduct of any trial. This article is a result of extensive research conducted by a reputed pharmaceutical company to identify the potential stages of risks associated with the conduct phase of trial that could impact the overall quality and safety of a trial...
November 19, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29165066/dysregulated-pathway-identification-of-alzheimer-s-disease-based-on-internal-correlation-analysis-of-genes-and-pathways
#12
Wei Kong, Xiaoyang Mou, Benteng Di, Jin Deng, Ruxing Zhong, Shuaiqun Wang
Dysregulated pathway identification is an important task which can gain insight into the underlying biological processes of disease. Current pathway-identification methods focus on a set of co-expression genes and single pathways and ignore the correlation between genes and pathways. The method proposed in this study, takes into account the internal correlations not only between genes but also pathways to identifying dysregulated pathways related to Alzheimer's disease (AD), the most common form of dementia...
November 20, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29164399/efficacy-of-a-single-intra-articular-injection-of-ultra-high-molecular-weight-hyaluronic-acid-for-hip-osteoarthritis-a-randomized-controlled-study
#13
Daniele Clementi, Riccardo D'Ambrosi, Paride Bertocco, Miguel Simon Bucci, Carlo Cardile, Paolo Ragni, Graziella Giaffreda, Vincenza Ragone
BACKGROUND: Viscosupplementation with hyaluronic acid (HA) is increasingly used for the treatment of hip osteoarthritis (OA). The purpose of this study was to compare the efficacy of intra-articular injections of an ultra-high molecular weight viscosupplement (UHMW-HA, Fermathron S) with a medium molecular weight hyaluronan (MMW-HA, Hyalubrix 60) in hip OA. METHODS: Fifty-four patients with hip OA grade 3 on the Kellgren/Lawrence scale were randomized. All infiltrations were performed under ultrasound guidance...
November 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29164343/determining-the-size-of-a-complete-disturbance-landscape-multi-scale-continental-analysis-of-forest-change
#14
Brian Buma, Jennifer K Costanza, Kurt Riitters
The scale of investigation for disturbance-influenced processes plays a critical role in theoretical assumptions about stability, variance, and equilibrium, as well as conservation reserve and long-term monitoring program design. Critical consideration of scale is required for robust planning designs, especially when anticipating future disturbances whose exact locations are unknown. This research quantified disturbance proportion and pattern (as contagion) at multiple scales across North America. This pattern of scale-associated variability can guide selection of study and management extents, for example, to minimize variance (measured as standard deviation) between any landscapes within an ecoregion...
November 21, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29164341/mathematical-models-of-hiv-latency
#15
Alison L Hill
Viral latency is a major barrier to curing HIV infection with antiretroviral therapy, and consequently, for eliminating the disease globally. The establishment, maintenance, and potential clearance of latent infection are complex dynamic processes and can be best understood and described with the help of mathematical models. Here we review the use of viral dynamics models for HIV, with a focus on applications to the latent reservoir. Such models have been used to explain the multiphasic decay of viral load during antiretroviral therapy, the early seeding of the latent reservoir during acute infection and the limited inflow during treatment, the dynamics of viral blips, and the phenomenon of posttreatment control...
November 22, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29163960/when-to-let-the-fellow-do-the-procedure
#16
Amnon Sonnenberg
Background and aims: In complex endoscopies, the initial attempt is often associated with the highest success and subsequent attempts to achieve the same outcome have a higher failure rate. An attending physician needs to decide how the ultimate success may become compromised by letting a fellow start the procedure. A decision analysis is aimed to shed light on this issue. Methods: A formula is derived to calculate the point in time when to switch the instrument between an attending and fellow physician...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29163945/pregnancy-associated-death-in-record-linkage-studies-relative-to-delivery-termination-of-pregnancy-and-natural-losses-a-systematic-review-with-a-narrative-synthesis-and-meta-analysis
#17
David C Reardon, John M Thorp
Objectives: Measures of pregnancy associated deaths provide important guidance for public health initiatives. Record linkage studies have significantly improved identification of deaths associated with childbirth but relatively few have also examined deaths associated with pregnancy loss even though higher rates of maternal death have been associated with the latter. Following PRISMA guidelines we undertook a systematic review of record linkage studies examining the relative mortality risks associated with pregnancy loss to develop a narrative synthesis, a meta-analysis, and to identify research opportunities...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29163939/infection-prevention-and-control-measures-and-tools-for-the-prevention-of-entry-of-carbapenem-resistant-enterobacteriaceae-into-healthcare-settings-guidance-from-the-european-centre-for-disease-prevention-and-control
#18
A P Magiorakos, K Burns, J Rodríguez Baño, M Borg, G Daikos, U Dumpis, J C Lucet, M L Moro, E Tacconelli, G Skov Simonsen, E Szilágyi, A Voss, J T Weber
Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and hospital costs. Patients who are "at-risk" may be carriers of these multidrug-resistant Enterobacteriaceae (MDR-E).The purpose of this guidance is to raise awareness and identify the "at-risk" patient when admitted to a healthcare setting and to outline effective infection prevention and control measures to halt the entry and spread of CRE...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29163928/understanding-single-enzyme-activity-via-the-nano-impact-technique
#19
Chuhong Lin, Enno Kätelhön, Lior Sepunaru, Richard G Compton
To evaluate the possible detection of single enzyme activity via electrochemical methods, a combined finite difference and random walk simulation is used to model individual enzyme-electrode collisions where such events are monitored amperometrically via the measurement of products formed by the enzyme in solution. It is found that the observed signal is highly sensitive to both the enzyme turnover number, the size of the electrode and the bandwidth of the electronics. Taking single catalase impacts as an example, simulation results are compared with experimental data...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163862/comparison-of-dsm-5-and-proposed-icd-11-criteria-for-ptsd-with-dsm-iv-and-icd-10-changes-in-ptsd-prevalence-in-military-personnel
#20
Annika Kuester, Kai Köhler, Thomas Ehring, Christine Knaevelsrud, Louisa Kober, Antje Krüger-Gottschalk, Ingo Schäfer, Julia Schellong, Ulrich Wesemann, Heinrich Rau
Background: Recently, changes have been introduced to the diagnostic criteria for posttraumatic stress disorder (PTSD) according to the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD). Objectives:This study investigated the effect of the diagnostic changes made from DSM-IV to DSM-5 and from ICD-10 to the proposed ICD-11. The concordance of provisional PTSD prevalence between the diagnostic criteria was examined in a convenience sample of 100 members of the German Armed Forces...
2017: European Journal of Psychotraumatology
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