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Skin biomaterial nanofiber

Guorui Jin, Jun Li, Kai Li
Photosensitive semiconducting polymer (SP) combined with light stimulation has shown the capability in promoting the proliferation of human dermal fibroblasts (HDFs). However, the high cytotoxicity of the used SP hindered its further application in bioactive scaffolds. In this contribution, we designed and synthesized a SP, poly (N,N-bis(2-octyldodecyl)-3,6-di(thiophen-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione-alt-thieno[3,2-b]thiophene) (PDBTT) with low cytotoxicity and strong absorbance in red and near-infrared region (600-1200nm)...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Dave Jao, Xiaoyang Mou, Xiao Hu
Silk proteins are natural biopolymers that have extensive structural possibilities for chemical and mechanical modifications to facilitate novel properties, functions, and applications in the biomedical field. The versatile processability of silk fibroins (SF) into different forms such as gels, films, foams, membranes, scaffolds, and nanofibers makes it appealing in a variety of applications that require mechanically superior, biocompatible, biodegradable, and functionalizable biomaterials. There is no doubt that nature is the world's best biological engineer, with simple, exquisite but powerful designs that have inspired novel technologies...
August 5, 2016: Journal of Functional Biomaterials
Tian Zhou, Nanping Wang, Yang Xue, Tingting Ding, Xin Liu, Xiumei Mo, Jiao Sun
The development of biomaterials with the ability to induce skin wound healing is a great challenge in biomedicine. In this study, tilapia skin collagen sponge and electrospun nanofibers were developed for wound dressing. The collagen sponge was composed of at least two α-peptides. It did not change the number of spleen-derived lymphocytes in BALB/c mice, the ratio of CD4(+)/CD8(+) lymphocytes, and the level of IgG or IgM in Sprague-Dawley rats. The tensile strength and contact angle of collagen nanofibers were 6...
July 1, 2016: Colloids and Surfaces. B, Biointerfaces
Said Mahmoud Ahmed, Hanaa Ahmed, Chang Tian, Qin Tu, Yadan Guo, Jinyi Wang
Design and fabrication of scaffolds using appropriate biomaterials are a key step for the creation of functionally engineered tissues and their clinical applications. Poly(epsilon-caprolactone) (PCL), a biodegradable and biocompatible material with negligible cytotoxicity, is widely used to fabricate nanofiber scaffolds by electrospinning for the applications of pharmaceutical products and wound dressings. However, the use of PCL as such in tissue engineering is limited due to its poor bioregulatory activity, high hydrophobicity, lack of functional groups and neutral charge...
July 1, 2016: Colloids and Surfaces. B, Biointerfaces
Ingrid Tamm, Jyrki Heinämäki, Ivo Laidmäe, Liisi Rammo, Urve Paaver, Sveinung G Ingebrigtsen, Nataša Škalko-Basnet, Anna Halenius, Jouko Yliruusi, Pauliina Pitkänen, Sami Alakurtti, Karin Kogermann
Suberin fatty acids (SFAs) isolated from outer birch bark were investigated as an antimicrobial agent and biomaterial in nanofibrous mats intended for wound treatment. Electrospinning (ES) was used in preparing the composite nonwoven nanomats containing chloramphenicol (CAM; as a primary antimicrobial drug), SFAs, and polyvinylpyrrolidone (as a carrier polymer for ES). The X-ray powder diffraction, differential scanning calorimetry, scanning electron microscopy, atomic force microscopy, and texture analysis were used for the physicochemical and mechanical characterization of the nanomats...
March 2016: Journal of Pharmaceutical Sciences
Zeinab Ghanavati, Niloofar Neisi, Vahid Bayati, Manoochehr Makvandi
Tissue engineering is a new field of which the main purpose is to regenerate and repair the damaged tissues. Scaffolds serve as three dimensional matrices for neo-organogenesis and their substance can be biologic or synthetic. Natural polymers have good interactions with the cells and synthetic biomaterials are also highly useful in biomedical application because of their biocompatible properties. In addition to scaffold substance, surface properties of biomaterials have an important role in tissue engineering...
December 2015: Anatomy & Cell Biology
Fateme Ahmadi-Aghkand, Shiva Gholizadeh-Ghaleh Aziz, Yunes Panahi, Hadis Daraee, Fateme Gorjikhah, Sara Gholizadeh-Ghaleh Aziz, Arash Hsanzadeh, Abolfazl Akbarzadeh
The largest organ of human body is skin, which acting as a barrier with immunologic, sensorial and protective functions. It is always in exposure to the external environment, which can result many different types of damage and injury with loss of variable volumes of extracellular matrix (ECM). For the treatment of skin lesions and damages, several approaches are now accessible, such as the application of allografts, autografts, and tissue-engineered substitutes, wound dressings and nanofiber scaffolds approaches...
November 2016: Artificial Cells, Nanomedicine, and Biotechnology
B P Antunes, A F Moreira, V M Gaspar, I J Correia
Frequently, skin is subjected to damaging events, such as deep cuts, burns or ulcers, which may compromise the integrity of this organ. To overcome such lesions, different strategies have been employed. Among them, wound dressings aimed to re-establish skin native properties and decreased patient pain have been pursued for a long time. Herein, an electrospun membrane comprised by deacetylated/arginine modified chitosan (CH-A) was produced to be used as a wound dressing. The obtained results showed that the membrane has a highly hydrophilic and porous three-dimensional nanofibrous network similar to that found in human native extracellular matrix...
October 5, 2015: Carbohydrate Polymers
Nor Hasrul Akhmal Ngadiman, Ani Idris, Muhammad Irfan, Denni Kurniawan, Noordin Mohd Yusof, Rozita Nasiri
Maghemite (γ-Fe2O3) nanoparticle with its unique magnetic properties is recently known to enhance the cell growth rate. In this study, γ-Fe2O3 is mixed into polyvinyl alcohol (PVA) matrix and then electrospun to form nanofibers. Design of experiments was used to determine the optimum parameter settings for the electrospinning process so as to produce elctrospun mats with the preferred characteristics such as good morphology, Young's modulus and porosity. The input factors of the electrospinnning process were nanoparticles content (1-5%), voltage (25-35 kV), and flow rate (1-3 ml/h) while the responses considered were Young's modulus and porosity...
September 2015: Journal of the Mechanical Behavior of Biomedical Materials
Dongyeop X Oh, Sangsik Kim, Dohoon Lee, Dong Soo Hwang
The main impediment to medical application of biomaterial-based adhesives is their poor wet adhesion strength due to hydration-induced softening and dissolution. To solve this problem, we mimicked the wound healing process found in tunicates, which use a nanofiber structure and pyrogallol group to heal any damage on its tunic under sea water. We fabricated a tunicate-mimetic hydrogel adhesive based on a chitin nanofiber/gallic acid (a pyrogallol acid) composite. The pyrogallol group-mediated cross-linking and the nanofibrous structures improved the dissolution resistance and cohesion strength of the hydrogel compared to the amorphous polymeric hydrogels in wet condition...
July 2015: Acta Biomaterialia
Jan Pelipenko, Petra Kocbek, Julijana Kristl
Electrospun polymer nanofibers have opened new opportunities in the rapidly evolving field of tissue engineering, particularly due to their topography and variability of available biomaterials. In order to better understand nanofiber influence on cell growth, the impact of their diameter was systematically examined. In this study homogenous, randomly oriented poly(vinyl alcohol) nanofibers with five different average diameters, ranging from 70nm to 1120nm, were produced, characterized and their impact on morphology, proliferation and mobility of keratinocytes and skin fibroblasts was evaluated...
January 23, 2015: European Journal of Pharmaceutical Sciences
Fernando G Torres, Solene Commeaux, Omar P Troncoso
Some bacteria can synthesize cellulose when they are cultivated under adequate conditions. These bacteria produce a mat of cellulose on the top of the culture medium, which is formed by a three-dimensional coherent network of pure cellulose nanofibers. Bacterial cellulose (BC) has been widely used in different fields, such as the paper industry, electronics and tissue engineering due to its remarkable mechanical properties, conformability and porosity. Nanocomposites based on BC have received much attention, because of the possibility of combining the good properties of BC with other materials for specific applications...
2012: Journal of Functional Biomaterials
Daniela Steffens, Dilmar Leonardi, Paula Rigon da Luz Soster, Michelle Lersch, Annelise Rosa, Thayane Crestani, Cristiane Scher, Michele Greque de Morais, Jorge Alberto Vieira Costa, Patricia Pranke
The combination of mesenchymal stem cells (MSCs) and nanotechnology to promote tissue engineering presents a strategy for the creation of new substitutes for tissues. Aiming at the utilization of the scaffolds of poly-d,l-lactic acid (PDLLA) associated or not with Spirulina biomass (PDLLA/Sp) in skin wounds, MSCs were seeded onto nanofibers produced by electrospinning. These matrices were evaluated for morphology and fiber diameter by scanning electron microscopy and their interaction with the MSCs by confocal microscopy analysis...
December 2014: Burns: Journal of the International Society for Burn Injuries
Linpeng Fan, Zengxiao Cai, Kuihua Zhang, Feng Han, Jingliang Li, Chuanglong He, Xiumei Mo, Xungai Wang, Hongsheng Wang
Silk fibroin (SF) from Bombyx mori has many established excellent properties and has found various applications in the biomedical field. However, some abilities or capacities of SF still need improving to meet the need for using practically. Indeed, diverse SF-based composite biomaterials have been developed. Here we report the feasibility of fabricating pantothenic acid (vitamin B5, VB5)-reinforcing SF nanofibrous matrices for biomedical applications through green electrospinning. Results demonstrated the successful loading of D-pantothenic acid hemicalcium salt (VB5-hs) into resulting composite nanofibers...
May 1, 2014: Colloids and Surfaces. B, Biointerfaces
Yanli Xi, Hua Dong, Kang Sun, Hongliang Liu, Ruiming Liu, Yuansen Qin, Zuojun Hu, Yong Zhao, Fuqiang Nie, Shutao Wang
This work investigates the influence of cytophilic and anisotropic nanomaterials on accelerated cell attachment and directional migration toward rapid wound healing. Inspired by the anisotropic protein nanofibers in scab, a polyurethane (PU) nanofibrous membrane with an aligned structure was fabricated. The membrane showed good affinity for wound-healing-related cells and could guide cell migration in the direction of PU nanofibers. Also, the morphology and distribution of F-actin and paxillin of attached cells were influenced by the underlying nanofibers...
June 12, 2013: ACS Applied Materials & Interfaces
Eun Seok Gil, Bruce Panilaitis, Evangelia Bellas, David L Kaplan
Silk protein-biomaterial wound dressings with epidermal growth factor (EGF) and silver sulfadiazine were studied with a cutaneous excisional mouse wound model. Three different material designs and two different drug incorporation techniques were studied to compare wound healing responses. Material formats included silk films, lamellar porous silk films and electrospun silk nanofibers, each studied with the silk matrix alone and with drug loading or drug coatings on the silk matrices. Changes in wound size and histological assessments of wound tissues showed that the functionalized silk biomaterial wound dressings increased wound healing rate, including reepithelialization, dermis proliferation, collagen synthesis and reduced scar formation, when compared to air-permeable Tegaderm tape (3M) (- control) and a commercial wound dressing, Tegaderm Hydrocolloid dressing (3M) (+ control)...
January 2013: Advanced Healthcare Materials
Mohammad A Alamein, Sebastien Stephens, Qin Liu, Stuart Skabo, Patrick H Warnke
AIM: Biomaterials that mimic the nanofibrous architecture of the natural extracellular matrix (ECM) are in the focus for stem cell hosting or delivery in tissue engineering of multilayered soft tissues such as skin, mucosa, or retina. Synthetic nanofibers for such ECM are usually produced by single-syringe electrospinning with only one needle-jet at very low production rates of 0.005-0.008 g·min⁻¹. The aim of this study was to utilize a novel industrial needle-free multijet electrospinning device with the potential for mass production of nanofibrous ECM (NF-ECM) exhibiting a controlled three-dimensional (3D) morphology for large-scale applications such as large area skin regeneration in patients with burns...
June 2013: Tissue Engineering. Part C, Methods
Dhakshinamoorthy Sundaramurthi, Kirthanashri Srinivasan Vasanthan, Purushothaman Kuppan, Uma Maheswari Krishnan, Swaminathan Sethuraman
Electrospinning is a versatile technique to make biomimetic and nanostructured scaffolds for skin tissue engineering. In this study we have electrospun and characterized chitosan (C)-poly(vinyl alcohol) (PVA) blend nanofibers as dermal substitutes and compared with 2D C-PVA films. The in vitro characterization of the C-PVA nanofibers and 2D films were evaluated using mouse 3T3 fibroblast cells and our results demonstrated that the cells adhered and proliferated on the surface of C-PVA nanofibers. In our animal studies, the implantation of C-PVA nanofibers along with topical administration of growth factor R-Spondin 1 on full thickness wounds created on rats showed 98...
August 2012: Biomedical Materials
R Krishnan, R Rajeswari, J Venugopal, S Sundarrajan, R Sridhar, M Shayanti, S Ramakrishna
Tissue engineering and nanotechnology have advanced a general strategy combining the cellular elements of living tissue with sophisticated functional biocomposites to produce living structures of sufficient size and function at a low cost for clinical relevance. Xylan, a natural polysaccharide was electrospun along with polyvinyl alcohol (PVA) to produce Xylan/PVA nanofibers for skin tissue engineering. The Xylan/PVA glutaraldehyde (Glu) vapor cross-linked nanofibers were characterized by SEM, FT-IR, tensile testing and water contact angle measurements to analyze the morphology, functional groups, mechanical properties and wettability of the fibers for skin tissue regeneration...
June 2012: Journal of Materials Science. Materials in Medicine
Victor T Tchemtchoua, Ganka Atanasova, Abdel Aqil, Patrice Filée, Nancy Garbacki, Olivier Vanhooteghem, Christophe Deroanne, Agnès Noël, Christine Jérome, Betty Nusgens, Yves Poumay, Alain Colige
The final goal of the present study was the development of a 3-D chitosan dressing that would shorten the healing time of skin wounds by stimulating migration, invasion, and proliferation of the relevant cutaneous resident cells. Three-dimensional chitosan nanofibrillar scaffolds produced by electrospinning were compared with evaporated films and freeze-dried sponges for their biological properties. The nanofibrillar structure strongly improved cell adhesion and proliferation in vitro. When implanted in mice, the nanofibrillar scaffold was colonized by mesenchymal cells and blood vessels...
September 12, 2011: Biomacromolecules
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