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Stroke MRI

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https://www.readbyqxmd.com/read/29352234/bi-exponential-3d-t1%C3%AF-mapping-of-whole-brain-at-3%C3%A2-t
#1
Rajiv G Menon, Azadeh Sharafi, Johannes Windschuh, Ravinder R Regatte
Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer's, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective T1ρ imaging study was performed on model relaxation phantoms (eggs) and 7 healthy volunteers. The data was fitted using a single pool and a 2-pool model to estimate mono- and bi-exponential T1ρ maps, respectively. Bi-exponential decays were identified in the gray matter (GM) and white matter (WM) of the brain with 40...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351787/scl20a2-mutation-presenting-with-acute-ischemic-stroke-a-case-report
#2
Xiaoyu Zhang, Gaoting Ma, Zhangning Zhao, Meijia Zhu
BACKGROUND: Primary familial brain calcification (PFBC) is a rare disorder characterized by distinctive bilateral brain calcification and variable clinical presentations. However, cerebrovascular attack was rarely reported in PFBC patients. We here reported a SLC20A2 mutation patient presenting with acute ischemic stroke. CASE PRESENTATION: A 56 years old man was transferred to our hospital because of 6 days of melena and 3 days of somnolence, agitation and mood changes...
January 19, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29350576/posterior-reversible-encephalopathy-syndrome-in-stroke-prone-spontaneously-hypertensive-rats-on-high-salt-diet
#3
Fanny Herisson, Iris Zhou, Jerome Mawet, E Du, Arnavaz H Barfejani, Tao Qin, Marilyn J Cipolla, Philip Z Sun, Natalia S Rost, Cenk Ayata
Stroke-prone spontaneously hypertensive rats (SHRSP) on high-salt diet are characterized by extremely high arterial pressures, and have been endorsed as a model for hypertensive small vessel disease and vascular cognitive impairment. However, rapidly developing malignant hypertension is a well-known cause of posterior reversible encephalopathy syndrome (PRES) in humans, associated with acute neurological deficits, seizures, vasogenic cerebral edema and microhemorrhages. In this study, we aimed to examine the overlap between human PRES and SHRSP on high-salt diet...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29344990/self-gated-golden-angle-spiral-4d-flow-mri
#4
Rene Bastkowski, Kilian Weiss, David Maintz, Daniel Giese
PURPOSE: The acquisition of 4D flow magnetic resonance imaging (MRI) in cardiovascular applications has recently made large progress toward clinical feasibility. The need for simultaneous compensation of cardiac and breathing motion still poses a challenge for widespread clinical use. Especially, breathing motion, addressed by gating approaches, can lead to unpredictable and long scan times. The current work proposes a time-efficient self-gated 4D flow sequence that exploits up to 100% of the acquired data and operates at a predictable scan time...
January 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29341020/mri-in-the-study-of-animal-models-of-stroke
#5
Pedro Ramos-Cabrer, Daniel Padro
Stroke consists of the loss of cerebral functions resulting from the interruption of blood supply to a region of the brain, and represents the second cause of death and the leading cause of major disability in adults in Europe. Stroke is a very active field of research at preclinical and clinical levels, and Magnetic Resonance Imaging (MRI) is one of the most powerful tools that scientist and clinicians have for the study of the onset, evolution and consequences of this devastating disease, as well as for the monitoring of the success of available treatments, or for the development of novel therapeutic strategies...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29341016/oxygenation-imaging-by-nuclear-magnetic-resonance-methods
#6
Heling Zhou, Nuria Arias-Ramos, Pilar López-Larrubia, Ralph P Mason, Sebastián Cerdán, Jesús Pacheco-Torres
Oxygen monitoring is a topic of exhaustive research due to its central role in many biological processes, from energy metabolism to gene regulation. The ability to monitor in vivo the physiological distribution and the dynamics of oxygen from subcellular to macroscopic levels is a prerequisite to better understand the mechanisms associated with both normal and disease states (cancer, neurodegeneration, stroke, etc.). This chapter focuses on magnetic resonance imaging (MRI) based techniques to assess oxygenation in vivo...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29341014/cardiac-mri-in-small-animals
#7
Min-Chi Ku, Till Huelnhagen, Thoralf Niendorf, Andreas Pohlmann
Cardiac magnetic resonance (MR) imaging of mice is a valuable tool for the precise in vivo diagnosis and prognosis of heart defects. This detailed protocol describes the method of cardiac MR imaging in mice step by step. A series of MR images captures the contractile function of the mouse heart and post-processing of the image data yields morphometric parameters (myocardial mass, myocardial wall thickness, ventricular end-systolic and end-diastolic volume) as well as functional parameters (stroke volume and ejection fraction)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29340831/noninvasive-quantification-of-left-to-right-shunt-by-phase-contrast-magnetic-resonance-imaging-in-secundum-atrial-septal-defect-the-effects-of-breath-holding-and-comparison-with-invasive-oximetry
#8
Yuzo Yamasaki, Satoshi Kawanami, Takeshi Kamitani, Koji Sagiyama, Ichiro Sakamoto, Ken-Ichi Hiasa, Hidetake Yabuuchi, Michinobu Nagao, Hiroshi Honda
To investigate the effect of breath-holding on left-to-right shunts in patients with a secundum atrial septal defect (ASD). Thirty-five consecutive patients with secundum ASDs underwent right heart catheterization and invasive oximetry. Phase-contrast magnetic resonance imaging (MRI) was performed for the main pulmonary artery and ascending aorta. All measurements were obtained during free breathing (FB) (quiet breathing; no breath-hold), expiratory breath-hold (EBH), and inspiratory breath-hold (IBH). Pulmonary circulation flow (Qp) and systemic circulation flow (Qs) were calculated by multiplying the heart rate by the stroke volume...
January 16, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29339771/etiology-of-language-network-changes-during-recovery-of-aphasia-after-stroke
#9
Casper A M M van Oers, H Bart van der Worp, L Jaap Kappelle, Mathijs A H Raemaekers, Willem M Otte, Rick M Dijkhuizen
Knowledge of spatiotemporal patterns of language network changes may help in predicting outcome in aphasic stroke patients. Here we assessed language function and performed functional MRI four times during one year to measure language network activation and cerebrovascular reactivity (with breath-holding) in twelve left-hemispheric stroke patients, of whom two dropped out before the final measurement, and eight age-matched controls. Language outcome was related to increase of activation in left and right posterior inferior temporal gyrus over the first year, while activation increase in right inferior frontal gyrus was inversely correlated to language recovery...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29338604/clinical-significance-of-cerebral-microbleeds-on-mri-a-comprehensive-meta-analysis-of-risk-of-intracerebral-hemorrhage-ischemic-stroke-mortality-and-dementia-in-cohort-studies-v1
#10
Andreas Charidimou, Sara Shams, Jose R Romero, Jie Ding, Roland Veltkamp, Solveig Horstmann, Gudny Eiriksdottir, Mark A van Buchem, Vilmundur Gudnason, Jayandra J Himali, M Edip Gurol, Anand Viswanathan, Toshio Imaizumi, Meike W Vernooij, Sudha Seshadri, Steven M Greenberg, Oscar R Benavente, Lenore J Launer, Ashkan Shoamanesh
Background Cerebral microbleeds can confer a high risk of intracerebral hemorrhage, ischemic stroke, death and dementia, but estimated risks remain imprecise and often conflicting. We investigated the association between cerebral microbleeds presence and these outcomes in a large meta-analysis of all published cohorts including: ischemic stroke/TIA, memory clinic, "high risk" elderly populations, and healthy individuals in population-based studies. Methods Cohorts (with > 100 participants) that assessed cerebral microbleeds presence on MRI, with subsequent follow-up (≥3 months) were identified...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29336359/white-matter-lesions-predict-recurrent-vascular-events-in-patients-with-transient-ischemic-attacks
#11
Xiao-Mei Ren, Shu-Wei Qiu, Ren-Yuan Liu, Wen-Bo Wu, Yun Xu, Hong Zhou
BACKGROUND: White matter lesions (WMLs) are common findings in brain magnetic resonance imaging (MRI) and are strongly associated with stroke incidence, recurrence, and prognosis. However, the relationship between WMLs and transient ischemic attacks (TIAs) is not well established. This study aimed to determine the clinical significance of WMLs in patients with TIA. METHODS: A total of 181 consecutive inpatients with first-ever TIA were enrolled. Brain MRIs within 2 days of symptom onset were used to measure WML volumes...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29335483/pilot-study-to-assess-visualization-and-therapy-of-inflammatory-mechanisms-after-vessel-reopening-in-a-mouse-stroke-model
#12
Ebba Beller, Laura Reuter, Anne Kluge, Christine Preibisch, Ute Lindauer, Alexei Bogdanov, Friederike Lämmer, Claire Delbridge, Kaspar Matiasek, Benedikt J Schwaiger, Tobias Boeckh-Behrens, Claus Zimmer, Alexandra S Gersing
After reperfusion therapy in stroke patients secondary inflammatory processes may increase cerebral damage. In this pilot study, effects of anti-inflammatory therapy were assessed in a middle cerebral artery occlusion (MCAO) mouse model after reperfusion. 1 hour after MCAO, the artery was reopened and tacrolimus or NaCl were administered intra-arterially. Perfusion-weighted (PWI) and diffusion-weighted images (DWI) were obtained by MRI during MCAO. DWI, T2- and T1-weighted images with and without Bis-5HT-DTPA administration were obtained 24 hours after MCAO...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29327286/abcd3-i-score-and-the-risk-of-early-or-3-month-stroke-recurrence-in-tissue-and-time-based-definitions-of-tia-and-minor-stroke
#13
Lukas Mayer, Julia Ferrari, Stefan Krebs, Christian Boehme, Thomas Toell, Benjamin Matosevic, Alexander Tinchon, Michael Brainin, Thomas Gattringer, Peter Sommer, Peter Thun, Johann Willeit, Wilfried Lang, Stefan Kiechl, Michael Knoflach
Changing definition of TIA from time to a tissue basis questions the validity of the well-established ABCD3-I risk score for recurrent ischemic cerebrovascular events. We analyzed patients with ischemic stroke with mild neurological symptoms arriving < 24 h after symptom onset in a phase where it is unclear, if the event turns out to be a TIA or minor stroke, in the prospective multi-center Austrian Stroke Unit Registry. Patients were retrospectively categorized according to a time-based (symptom duration below/above 24 h) and tissue-based (without/with corresponding brain lesion on CT or MRI) definition of TIA or minor stroke...
January 11, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29327165/measurement-of-cardiac-valve-and-aortic-blood-flow-velocities-in-stroke-patients-a-comparison-of-4d-flow-mri-and-echocardiography
#14
Thomas Wehrum, Felix Guenther, Alexander Fuchs, Florian Schuchardt, Anja Hennemuth, Andreas Harloff
4D flow MRI is an emerging technique that allows quantification of 3D blood flow in vivo. However, comparisons with methods of blood velocity quantification used in clinical routine are sparse. Therefore, we compared velocity quantification using 4D flow MRI with transthoracic and transesophageal echocardiography at the mitral and aortic valves and the aorta. Forty-eight stroke patients (age 67.3 ± 15.0 years) were examined by 4D flow MRI. Blood flow velocities were assessed using standardized 2D analysis planes positioned in the mitral valve (MV), aortic valve (AV), ascending aorta (AAo), and descending aorta (DAo) and were compared with echocardiography...
January 11, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29326378/the-casper-stent-system-for-carotid-artery-stenosis
#15
Sebastian J Mutzenbach, Katharina Millesi, Cornelia Roesler, Erasmia Broussalis, Slaven Pikija, Johann Sellner, Lukas Machegger, Christoph J Griessenauer, Monika Killer-Oberpfalzer
PURPOSE: To report the results of a retrospective analysis of prospectively collected data evaluating the safety and efficacy of a double layer stent engineered for carotid artery occlusive disease. METHODS: Between January 2014 and February 2017, 138 patients (25.4% women; median age 71 years) underwent Casper stent implantation for carotid artery stenosis. Eligibility criteria included stenosis >70% of vessel diameter (or >50% diameter with ulceration) in symptomatic patients or asymptomatic patients with >80% stenosis at the carotid bifurcation or in the proximal internal carotid artery...
January 11, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29326371/mycoplasma-pneumoniae-infection-presenting-as-stroke-and-meningoencephalitis-with-aortic-and-subclavian-aneurysms-without-pulmonary-involvement
#16
Pournamy Sarathchandran, Abubaker Al Madani, Ayman M Alboudi, Jihad Inshasi
A 39-year-old Philipino man presented with acute onset fever and headache. Neurological examination was normal except for neck stiffness. There was no history of chest pain, cough or breathlessness. Cerebrospinal fluid (CSF) showed a mild increase in protein with normal sugar and lymphocytic pleocytosis. CSF PCR for herpes simplex and varicella zoster virus was negative. He developed acute right haemiplegia a week after hospitalisation. MRI showed acute infarct in the left centrum semiovale. His angiogram showed aneurysm in the left subclavian artery and aortic arch...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29326289/prevalence-of-hippocampal-enlarged-perivascular-spaces-in-a-sample-of-patients-with-hypertension-and-their-relation-with-vascular-risk-factors-and-cognitive-function
#17
Joan Jiménez-Balado, Iolanda Riba-Llena, Edurne Garde, Marta Valor, Belen Gutiérrez, Francesc Pujadas, Pilar Delgado
OBJECTIVES: The clinical importance of hippocampal enlarged perivascular spaces (H-EPVS) remains uncertain. We aimed to study their association with vascular risk factors, cognitive function and mild cognitive impairment (MCI). METHODS: Data were obtained from the ISSYS (Investigating Silent Strokes in hYpertensives, a magnetic resonance imaging Study) cohort, which is a prospective study of patients with hypertension aged 50-70 with no prior stroke or dementia...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29322338/the-oscillatory-flow-of-the-cerebrospinal-fluid-in-the-sylvian-aqueduct-and-the-prepontine-cistern-measured-with-phase-contrast-mri-in-children-with-hydrocephalus-a-preliminary-report
#18
Emilia Nowosławska, Dominika Gwizdała, Dobromiła Barańska, Piotr Grzelak, Michał Podgórski, Krzysztof Zakrzewski, Bartosz Polis, Mariusz Stasiołek, Lech Polis
INTRODUCTION: Recognizing patients with ventriculomegaly who are at risk of developing acute hydrocephalus presents a challenge for the clinician. The association between disturbed cerebrospinal fluid flow (CSF) and impaired brain compliance may play a role in the pathogenesis of hydrocephalus. Phase contrast MRI is a noninvasive technique which can be used to assess CSF parameters. The aim of the work is to evaluate the effectiveness of phase contrast MRI in recognizing patients at risk of acute hydrocephalus, based on measuring the pulsatile CSF flow parameters in the Sylvian aqueduct and prepontine cistern in children with ventriculomegaly...
January 10, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29321138/sensorimotor-functional-and-structural-networks-after-intracerebral-stem-cell-grafts-in-the-ischemic-mouse-brain
#19
Claudia Green, Anuka Minassian, Stefanie Vogel, Michael Diedenhofen, Andreas Beyrau, Dirk Wiedermann, Mathias Hoehn
Past investigations on stem cell mediated recovery after stroke have limited their focus on the extent and morphological development of the ischemic lesion itself over time or on the integration capacity of the stem cell graft ex vivo However, an assessment of the long-term functional and structural improvement in vivo is essential to reliably quantify the regenerative capacity of cell implantation after stroke.We induced ischemic stroke in nude mice and implanted human neural stem cells (H9 derived) into the ipsilateral cortex in the acute phase...
January 10, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29316820/cost-effectiveness-of-access-to-critical-cerebral-emergency-support-services-access-a-neuro-emergent-telemedicine-consultation-program
#20
Justin Whetten, David N van der Goes, Huy Tran, Mark Moffett, Colin Semper, Howard Yonas
AIMS: Access to Critical Cerebral Emergency Support Services (ACCESS) was developed as a low-cost solution to providing neuro-emergent consultations to rural hospitals in New Mexico that do not offer comprehensive stroke care. ACCESS is a two-way audio visual program linking remote emergency department physicians and their patients to stroke specialists. ACCESS also has an education component in which hospitals receive training from stroke specialists on the triage and treatment of patients...
January 9, 2018: Journal of Medical Economics
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