Jiaying Xie, Mengyao Sheng, Shaoqin Rong, Dan Zhou, Chao Wang, Wanling Wu, Jingru Huang, Yue Sun, Yin Wang, Pingyue Chen, Yushuang Wu, Yuanxian Wang, Lan Wang, Bo O Zhou, Xinxin Huang, Colum P Walsh, Stefan K Bohlander, Jian Huang, Xiaoqin Wang, Guo-Liang Xu, Hai Gao, Yuheng Shi
Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2) occur frequently in individuals with clonal hematopoiesis (CH) and acute myeloid leukemia (AML). These common hematopoietic disorders can be recapitulated in mouse models. However, the underlying mechanisms by which the deficiency in TET2 promotes these disorders remain unclear. Here we show that the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway is activated to mediate the effect of TET2 deficiency in dysregulated hematopoiesis in mouse models...
October 10, 2023: Leukemia