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https://www.readbyqxmd.com/read/29769143/clinical-outcome-of-elderly-patients-%C3%A2-70-years-with-esophageal-cancer-undergoing-definitive-or-neoadjuvant-radio-chemo-therapy-a-retrospective-single-center-analysis
#1
Franziska Walter, David Böckle, Nina-Sophie Schmidt-Hegemann, Rebecca Köpple, Sabine Gerum, Stefan Boeck, Martin Angele, Claus Belka, Falk Roeder
BACKGROUND: To analyse the outcome of elderly patients (≥70 years) with esophageal cancer treated with curative intent radio(chemo)therapy. METHODS: Fifty five patients (median 75 years) receiving curative intent radio(chemo)therapy for esophageal cancer from 1999 to 2015 were retrospectively analyzed. Most patients showed locally advanced disease (T3/4:78%, N+:58%) with squamous cell histology (74%). Charlson comorbidity score was > 1 in 27%. 48 patients (87%) received definitive treatment while 7 patients were treated neoadjuvantly...
May 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29764470/joint-preserving-palliative-surgery-using-self-locking-screws-of-intramedullary-nail-and-percutaneous-cementoplasty-for-proximal-humeral-metastasis-in-the-advanced-cancer-patients
#2
Jong Woong Park, Yong-Il Kim, Hyun Guy Kang, June Hyuk Kim, Han Soo Kim
BACKGROUND: We introduced a palliative joint-preserving surgery using proximal self-locking screws of intramedullary (IM) nail and percutaneous cementoplasty (PC) in patients with proximal humeral metastases, including the head and neck, and evaluated the outcome of the surgical method. METHODS: Twenty-three patients (mean age = 63.0 ± 11.8 years, M:F = 14:9) had IM nailing with a self-locking screw system and PC for the treatment of humeral head and neck metastases...
May 15, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29750538/stereotactic-body-radiation-therapy-for-liver-oligometastases-predictive-factors-of-local-response-by-18f-fdg-pet-ct
#3
Rosario Mazzola, Sergio Fersino, Pierpaolo Alongi, Gioacchino Di Paola, Fabiana Gregucci, Dario Aiello, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVE: to investigate metabolic parameters as predictive of local response after Stereotactic Body Radiation Therapy (SBRT) for liver-oligometastases Methods: Inclusion criteria of the present retrospective study were: a) liver oligometastases with controlled primary tumor; b) absence of progressive disease ≥6 months; c) metastases ≤ 3; d) evaluation of SBRT-response by means of 18-FDG-PET/CT for at least two subsequent evaluations; e) Karnofsky performance status >80; f) life-expectancy >6 months...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29745630/evaluation-of-multifunctional-imaging-parameters-in-gastro-oesophageal-cancer-using-f-18-fdg-pet-ct-with-integrated-perfusion-ct
#4
Bert-Ram Sah, Christian A Leissing, Gaspar Delso, Edwin E Ter Voert, Stefan Krieg, Sebastian Leibl, Paul M Schneider, Cäcilia S Reiner, Martin W Hüllner, Patrick Veit-Haibach
BACKGROUND: Positron emission tomography (PET) / computed tomography (CT) is among the most frequently used imaging modalities for initial staging of gastro-oesophageal (GE) cancer, whereas CT-perfusion (CTP) provides different multiparametric information. This proof of concept study compares CTP- and PET-parameters in patients with GE cancer to evaluate correlations and a possible prognostic value of a combined PET/CTP imaging procedure. METHODS: A total of 31 patients with F-18-FDG-PET/CT and CTP studies were prospectively analysed...
May 10, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29743108/-18-fdg-pet-ct-identifies-histopathological-non-responders-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-and-cardia-cancer-cohort-study
#5
Paul M Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras, Kuno Lehmann
BACKGROUND: Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction (AEG) cancer, the accuracy of FDG PET-CT to predict early pathologic response after neoadjuvant chemotherapy (neoCTX) is currently not known. METHODS: From a consecutive cohort of 72 patients, 44 patients with resectable, locally-advanced gastric cancer or AEG Siewert type II and III received neoCTX after primary staging with endoscopic ultrasound, PET-CT and laparoscopy...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29730697/risk-related-18-f-fdg-pet-ct-and-new-diagnostic-strategies-in-patients-with-solitary-pulmonary-nodule-the-italian-multicenter-trial
#6
Marco Spadafora, Leonardo Pace, Laura Evangelista, Luigi Mansi, Francesco Del Prete, Giorgio Saladini, Paolo Miletto, Stefano Fanti, Silvana Del Vecchio, Luca Guerra, Giovanna Pepe, Giuseppina Peluso, Emanuele Nicolai, Giovanni Storto, Marco Ferdeghini, Alessandro Giordano, Mohsen Farsad, Orazio Schillaci, Cesare Gridelli, Alberto Cuocolo
PURPOSE: Diagnosis of solitary pulmonary nodule (SPN) is an important public health issue and 18 F-FDG PET/CT has proven to be more effective than CT alone. Pre-test risk stratification and clinical presentation of SPN could affect the diagnostic strategy. A relevant issue is whether thoracic segmental (s)-PET/CT could be implemented in patients with SPN. This retrospective multicenter study compared the results of FDG whole-body (wb)-PET/CT to those of s-PET/CT. METHODS: 18 F-FDG PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed...
May 5, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29721764/18-fdg-pet-in-a-patient-cohort-suspected-for-cardiac-sarcoidosis-right-ventricular-uptake-is-associated-with-pathological-uptake-in-mediastinal-lymph-nodes
#7
Heikki Tuominen, Atte Haarala, Antti Tikkakoski, Mika Kähönen, Kjell Nikus, Kalle Sipilä
INTRODUCTION: In up to 65% of cardiac sarcoidosis patients, the disease is confined to the heart. Diagnosing isolated cardiac sarcoidosis is challenging due to the low sensitivity of endomyocardial biopsy. If cardiac sarcoidosis is part of biopsy-confirmed systemic sarcoidosis, the diagnosis can be based on cardiac imaging studies. We compared the imaging features of patients with isolated cardiac FDG uptake on positron emission tomography with those who had findings indicative of systemic sarcoidosis...
May 2, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29719160/propolis-protects-endotoxin-induced-acute-lung-and-liver-inflammation-through-attenuating-inflammatory-responses-and-oxidative-stress
#8
Berat Yangi, Mehmet Cengiz Ustuner, Murat Dincer, Cansu Ozbayer, Neslihan Tekin, Derya Ustuner, Emine Colak, Umut Kerem Kolac, Emre Entok
Propolis is a natural bee product, and it has many effects, including antioxidant, anti-inflammatory, antihepatotoxic, and anticancer activity. In this study, we aimed to explore the potential in vivo anti-inflammatory, antioxidant, and antiapoptotic properties of propolis extract on lipopolysaccharide (LPS)-induced inflammation in rats. Forty-two, 3- to 4-month-old male Sprague Dawley rats were used in six groups. LPS (1 mg/kg) was administered intraperitoneally to rats in inflammation, inflammation + propolis30, and inflammation+propolis90 groups...
May 2, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29707993/procalcitonin-as-a-postoperative-marker-in-the-follow-up-of-patients-affected-by-medullary-thyroid-carcinoma
#9
Pierpaolo Trimboli, Rosa Lauretta, Agnese Barnabei, Stefano Valabrega, Francesco Romanelli, Luca Giovanella, Marialuisa Appetecchia
AIM: Due to the limits of calcitonin, other markers are warranted to better manage medullary thyroid carcinoma patients, and procalcitonin has been reported as promising. Here we aimed to evaluate procalcitonin as a marker of medullary thyroid carcinoma in the post-treatment follow-up. METHODS: Medullary thyroid carcinoma patients previously treated by thyroidectomy were enrolled. After complete imaging work-up (i.e. ultrasonography, computed tomography, magnetic resonance and 18 FDG-PET-CT) we identified patients with structural recurrent/persistent medullary thyroid carcinoma (active medullary thyroid carcinoma) and subjects with no evidence of disease...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29705152/evaluation-of-diffuse-large-b-cell-lymphoma-patients-with-64-slice-multidetector-computed-tomography-versus-18-fdg-positron-emission-tomography-computed-tomography-in-initial-staging-and-restaging-after-treatment
#10
Nieves Gómez León, Gema Vega, Beatriz Rodríguez-Vigil Junco, Carlos Suevos Ballesteros
BACKGROUND AND OBJECTIVES: To prospectively compare the accuracy in initial staging and end-of-treatment restaging of diffuse large B-cell lymphoma (DLBCL) between 64-slice multidetector computed tomography (64MDCT) and 18FDG positron emission tomography/computed tomography (18FGD PET/CT) with intravenous contrast injection. MATERIAL AND METHODS: Randomised and blind controlled clinical multicentric trial that included biopsy-proven DLBCL patients. Seventy-two patients from five different hospitals in the region of Madrid, Spain, were enrolled in the study between January 2012 and June 2015...
April 25, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29695997/the-anatomo-electrical-network-underlying-hypermotor-seizures
#11
Xiu Wang, Wenhan Hu, Kai Zhang, Xiaoqiu Shao, Yanshan Ma, Lin Sang, Zhong Zheng, Chao Zhang, Junjv Li, Jian-Guo Zhang
Purpose: Hypermotor seizures (HMS) can be triggered by different epileptogenic foci and thus common symptomatic networks generating HMS may exist among these patients. The goal of the present study was to investigate the specialized networks underlying HMS by analyzing interictal 18 FDG-PET imaging and ictal stereo-electroencephalography (SEEG) recordings. Methods: Fourteen patients with HMS were retrospectively analyzed. HMS were classified into HMS1 and HMS2 according to the speed and intensity of the motor seizure behavior...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29694635/outcomes-of-patients-with-bone-metastases-from-differentiated-thyroid-cancer
#12
Inés Califano, Susana Deutsch, Alicia Löwenstein, Carmen Cabezón, Fabián Pitoia
Objective Bone metastases (BM) from differentiated thyroid cancer (DTC) are associated with poor survival rates. Due to the low frequency of this entity, we performed a multicentric retrospective study that aimed to evaluate the presentation, outcome and causes of death in this population. Subjects and methods We reviewed file records from 10 databases. BM were diagnosed by: i) biopsy and/or ii) radioiodine (RAI) bone uptake + elevated thyroglobulin (Tg) levels and/or c) bone uptake of 18-FDG in the PET-CT scan + elevated Tg levels...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29684783/accurate-segmenting-of-cervical-tumors-in-pet-imaging-based-on-similarity-between-adjacent-slices
#13
Liyuan Chen, Chenyang Shen, Zhiguo Zhou, Genevieve Maquilan, Kimberly Thomas, Michael R Folkert, Kevin Albuquerque, Jing Wang
Because in PET imaging cervical tumors are close to the bladder with high capacity for the secreted 18 FDG tracer, conventional intensity-based segmentation methods often misclassify the bladder as a tumor. Based on the observation that tumor position and area do not change dramatically from slice to slice, we propose a two-stage scheme that facilitates segmentation. In the first stage, we used a graph-cut based algorithm to obtain initial contouring of the tumor based on local similarity information between voxels; this was achieved through manual contouring of the cervical tumor on one slice...
April 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29668594/f-18-fdg-pet-ct-and-mri-for-detecting-the-malignant-potential-in-patients-with-gastrointestinal-stromal-tumors-a-protocol-for-a-network-meta-analysis-of-diagnostic-test-accuracy
#14
Kongyuan Wei, Bei Pan, Huan Yang, Cuncun Lu, Long Ge, Nong Cao
BACKGROUND: Gastrointestinal stromal tumor (GIST) is a rare cancer in gastrointestinal carcinomas and has been widely known as a curable disease among all the digestive tumors. However, early detection of malignant potential in patients with GIST has still been a huge challenge all around the world. CT, MRI, and F-18 FDG PET are all considered as good tests for diagnosing malignant GIST efficiently, but no recommended suggestions presents which test among the 3 is the prior one in detecting the malignant potential of GIST...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29662649/-18-fdg-pet-ct-and-molecular-markers-to-predict-response-to-neoadjuvant-chemotherapy-and-outcome-in-her2-negative-advanced-luminal-breast-cancers-patients
#15
Patricia de Cremoux, Lucie Biard, Brigitte Poirot, Philippe Bertheau, Luis Teixeira, Jacqueline Lehmann-Che, Fatiha A Bouhidel, Pascal Merlet, Marc Espié, Matthieu Resche-Rigon, Christos Sotiriou, David Groheux
Background: The efficacy of neoadjuvant chemotherapy regimens in advanced luminal breast cancer patients is difficult to predict. Intrinsic properties of breast tumors, including altered gene expression profile and dynamic evaluation of metabolic properties of tumor cells using positron emission tomography/computed tomography (PET/CT) of tumor cells, have been identified to guide patient's prognosis. The aim of this study is to determine if both analyses may improve the prediction of response to neoadjuvant chemotherapy in ER-positive / HER2-negative breast cancers (BCs) patients...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662565/follicular-lymphoma-mimicking-metastatic-nodes-on-the-f-18-fdg-pet-ct-and-mri-for-staging-of-endometrial-cancer
#16
Seok-Nam Yoon
A 53-year-old woman was diagnosed with endometrial carcinoma by vaginal bleeding. F-18 fluorodeoxy glucose positron emission tomography PET/CT (F-18 FDG PET/CT) scan for staging showed intense focal FDG uptake in the endometrium suggesting endometrial malignancy. PET/CT showed multiple node uptakes in the pericaval region, paraaortic region, common iliac, and both internal iliac and external iliac regions suggesting multiple pelvic and retroperitoneal node metastases. MRI showed multiple metastatic lymphadenopathy in the retroperitoneum and pelvic cavity...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662562/the-predictive-values-of-lesion-size-f-18-fdg-avidity-and-i-131-avidity-for-the-clinical-outcome-of-i-131-treatment-in-patients-with-metastatic-differentiated-thyroid-carcinoma-only-in-the-lung
#17
Joon Ho Choi, Byung Hyun Byun, Ilhan Lim, Hansol Moon, Jihyun Park, Kyoung Jin Chang, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
Purpose: We aimed to evaluate the prognostic values of radiography, F-18 FDG PET, and I-131 whole body scans in patients with lung-only metastasis from differentiated thyroid carcinoma (DTC). Methods: Between 1998 and 2013, we included 31 patients (F: 26, M: 5) with lung-only metastasis from DTC who had been treated with I-131 and underwent PET. Lung metastasis was categorized according to the size (macronodular ≥1.0 cm vs. micronodular <1.0 cm), FDG avidity (avid vs...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29656743/prognostic-stratification-model-for-patients-with-stage-i-non-small-cell-lung-cancer-adenocarcinoma-treated-with-surgical-resection-without-adjuvant-therapies-using-metabolic-features-measured-on-f-18-fdg-pet-and-postoperative-pathologic-factors
#18
Yeon-Koo Kang, Yoo Sung Song, Sukki Cho, Sanghoon Jheon, Won Woo Lee, Kwhanmien Kim, Sang Eun Kim
PURPOSE: In the management of non-small cell lung cancer (NSCLC), the prognostic stratification of stage I tumors without indication of adjuvant therapy, remains to be elucidated in order to better select patients who can benefit from additional therapies. We aimed to stratify the prognosis of patients with stage I NSCLC adenocarcinoma using clinicopathologic factors and F-18 FDG PET. MATERIALS AND METHODS: We retrospectively enrolled 128 patients with stage I NSCLC without any high-risk factors, who underwent curative surgical resection without adjuvant therapies...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29643671/role-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-various-orbital-malignancies
#19
Aravintho Natarajan, Piyush Chandra, Nilendu Purandare, Archi Agrawal, Sneha Shah, Ameya Puranik, Venkatesh Rangarajan
Orbital swelling comprises wide spectrum of pseudotumors, benign and malignant tumor. Malignant tumor may be primary or secondary tumor, and they constitute about 36% of orbital tumors in adult. Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) scan is extensively used in hematological malignancies and in solid tumors for staging, treatment response, and restaging. Recently, the use of FDG-PET/CT in orbital malignancies has gained importance. The aim of this pictorial essay is to illustrate few important orbital malignancies detected in F-18 FDG-PET/CT and discuss its role in assessing the primary lesion and associated systemic finding...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29603322/functional-visceral-fat-activity-evaluated-by-preoperative-f-18-fdg-pet-ct-predicts-regional-lymph-node-metastasis-in-differentiated-thyroid-cancer
#20
Kisoo Pahk, Sunju Choi, Sungeun Kim
OBJECTIVE: We investigated the predictive role of functional visceral fat activity evaluated by preoperative F-18 FDG PET/CT for regional lymph node metastasis in patients with differentiated thyroid cancer. DESIGN AND PATIENTS: Fifty-eight patients with newly diagnosed differentiated thyroid cancer were enrolled in this study, retrospectively (men 14; women 44; age 53 ± 14.5). They all received preoperative F-18 FDG PET/CT and surgery. Functional visceral fat activity was defined as maximum standardized uptake value (SUVmax) of visceral fat divided by SUVmax of subcutaneous fat (V/S ratio)...
March 30, 2018: Clinical Endocrinology
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