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https://www.readbyqxmd.com/read/27902598/correlation-of-glut-1-and-glut-3-expression-with-f-18-fdg-uptake-in-pulmonary-inflammatory-lesions
#1
Zhen Guang Wang, Ming Ming Yu, Yu Han, Feng Yu Wu, Guang Jie Yang, Da Cheng Li, Si Min Liu
The aim of the study was to investigate the correlation of glucose transporter-1 (Glut-1) and glucose transporter-3 (Glut-3) expression with F-18 FDG uptake in pulmonary inflammatory lesions.Twenty-two patients with pulmonary inflammatory lesions underwent positron emission tomography/computed tomography (PET/CT) examination preoperatively, and Glut-1 and Glut-3 expression were detected by immunohistochemistry in these lesions. Correlations of Glut-1 and Glut-3 with F-FDG uptake were assessed using Spearman's rank correlation test...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27895731/advantages-and-disadvantages-of-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-carcinoma-of-unknown-primary
#2
Xiaozhou Yu, Xiaofeng Li, Xiuyu Song, Dong Dai, Lei Zhu, Yanjia Zhu, Jian Wang, Huiqin Zhao, Wengui Xu
Carcinoma of unknown primary is a type of malignant disease where the primary carcinoma cannot be identified by conventional examination, which presents challenges in diagnosis and therapy. This study aims to evaluate the detailed clinical value and indications of using fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in a large sample. A total of 449 patients who were selected under strict standards were retrospectively included in this study. F-18 FDG PET/CT accurately detected the primary carcinoma in 115 of 449 patients whose primaries could not be detected by conventional examination (25...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27886616/serial-fdg-pet-scans-help-to-identify-steroid-resistance-in-cardiac-sarcoidosis
#3
Abhijeet B Shelke, Hrushikesh U Aurangabadkar, Jason S Bradfield, Zakir Ali, K Shiv Kumar, Calambur Narasimhan
BACKGROUND: Cardiac sarcoidosis (CS) is increasingly being recognized. Immunosuppression with corticosteroids is the mainstay of therapy. But the optimal dose of steroids and how to assess response to therapy is not known. Prognosis is poor if these patients are untreated or undertreated. Fluorine-18-flurodeoxyglucose positron emission computed tomography ((18)FDG-PET CT) is a sensitive tool in diagnosing CS. It correlates closely with the level of granulomatous inflammation and can be used to monitor response to therapy...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27876341/imaging-of-neuroendocrine-tumors-of-the-pancreas
#4
C Dromain, D Déandréis, J-Y Scoazec, D Goere, M Ducreux, E Baudin, L Tselikas
Pancreatic neuroendocrine tumors (PNETs) are rare and represent a heterogeneous disease. PNET can be functioning or non-functioning with different clinical presentations and different prognosis based on WHO and pTNM classifications. The role of imaging includes the localization of small functioning tumor, differentiation of these tumors from adenocarcinoma, identification of signs of malignancy and evaluation of extent. PNETs have a broad spectrum of appearance. On CT and MRI, most of functioning PNETs are well defined small tumors with intense and homogeneous enhancement on arterial and portal phases...
November 18, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27843550/accuracy-and-cost-effectiveness-of-dynamic-contrast-enhanced-ct-in-the-characterisation-of-solitary-pulmonary-nodules-the-sputnik-study
#5
N R Qureshi, R C Rintoul, K A Miles, S George, S Harris, J Madden, K Cozens, L A Little, K Eichhorst, J Jones, P Moate, C McClement, L Pike, D Sinclair, W L Wong, J Shekhdar, R Eaton, A Shah, L Brindle, C Peebles, A Banerjee, S Dizdarevic, S Han, F W Poon, A M Groves, L Kurban, A J Frew, M E Callister, P Crosbie, F V Gleeson, K Karunasaagarar, O Kankam, F J Gilbert
INTRODUCTION: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently. METHODS AND ANALYSIS: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) ((18)FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS)...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27833314/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-idiopathic-pulmonary-fibrosis-a-new-ray-of-hope
#6
Unnati Desai, Vinaya S Karkhanis, Sandip Basu, Jyotsna M Joshi
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with median survival of 2-3 years. It is described as fibroproliferative rather than pro-inflammatory disorder with limited treatment options. IPF diagnostics and therapeutics are a hot topic of current research. We describe a case elaborating the utility of the whole body positron emission tomography with 2-deoxy-2-(fluorine-18) fluoro-D-glucose (F-18 FDG) integrated with computed tomography technique in IPF. The area of most intense pulmonary F--18 FDG uptake corresponded to regions of honeycombing suggesting metabolically active disease amenable to pharmacologic intervention...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27824970/a-pediatric-malignant-paraganglioma-and-brief-review-of-the-literature
#7
Jinhua Zi, Chao Ma, Changyun Xu, Yongli Bai
: A 10 years old boy presented to our hospital complaining of belly pain. He had a retroperitoneal mass diagnosed by ultrasound 3 days before. During that time he was found to have slight hypertension. Computed tomography (CT) showed a left retroperitoneal mass with edge enhancement and central necrosis indicating pheochromocytoma (PCC). Vanillymandelic acid (VMA) in the 24 hours urine sample was not elevated. Pheochromocytoma was suspected given his hypertension and the ultrasound and CT findings...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27818005/immune-mediated-disease-in-ipilimumab-immunotherapy-of-melanoma-with-fdg-pet-ct
#8
REVIEW
Jason W Wachsmann, Ramapriya Ganti, Fangyu Peng
RATIONALE AND OBJECTIVES: The purposes of this study were to provide a case-based overview of various immune-mediated side effects detected by 18F-Fluorodeoxyglucose (F-18 FDG) positron emission tomography-computed tomography (PET-CT) in the patients receiving ipilimumab immunotherapy for treatment of malignant melanoma, and discuss the importance of recognizing immune-mediated side effects in the use of F-18 FDG PET-CT for monitoring therapeutic effects of ipilimumab on metastatic melanoma...
November 4, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27816687/early-change-in-fdg-pet-signal-and-plasma-cell-free-dna-level-predicts-erlotinib-response-in-egfr-wild-type-nsclc-patients
#9
Anne Winther-Larsen, Joan Fledelius, Christina Demuth, Catharina M Bylov, Peter Meldgaard, Boe S Sorensen
INTRODUCTION: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are a treatment option in the second- or third-line palliative setting in EGFR wild-type (wt) non-small cell lung cancer (NSCLC) patients. However, response rates are low, and only approximately 25% will achieve disease control. Early prediction of treatment resistance could accelerate discontinuation of ineffective treatment and reduce unnecessary toxicity. In this study, we evaluated early changes on 18F-fluoro-D-glucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) and in total plasma cell-free DNA (cfDNA) as markers of erlotinib response in EGFR-wt patients...
October 28, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27796945/inhibition-of-blood-brain-barrier-disruption-by-an-apolipoprotein-e-mimetic-peptide-ameliorates-early-brain-injury-in-experimental-subarachnoid-hemorrhage
#10
Jinwei Pang, Yitian Chen, Li Kuai, Ping Yang, Jianhua Peng, Yue Wu, Yue Chen, Michael P Vitek, Ligang Chen, Xiaochuan Sun, Yong Jiang
Apolipoprotein E (ApoE)-mimetic peptides have been demonstrated to be beneficial in secondary brain injury following experimental subarachnoid hemorrhage (SAH). However, the molecular mechanisms underlying these benefits in SAH models have not been clearly identified. This study investigated whether an ApoE-mimetic peptide affords neuroprotection in early brain injury (EBI) following SAH by attenuating BBB disruption. SAH was induced by an endovascular perforation in young, healthy, male wild-type (WT) C57BL/6J mice...
October 31, 2016: Translational Stroke Research
https://www.readbyqxmd.com/read/27785973/hepatic-radiation-injury-mimicking-metastasis-in-distal-esophageal-cancer
#11
Karel Demey, Hans Van Veer, Philippe Nafteux, Christophe M Deroose, Karin Haustermans, Johan Coolen, Vincent Vandecaveye, Willy Coosemans, Eric Van Cutsem
INTRODUCTION: A new hypermetabolic lesion on (18)FDG-PET/CT after neo-adjuvant chemoradiotherapy for distal esophageal cancer can be a hepatic metastasis and should be examined carefully before esophagectomy. CASE-REPORT: We present a case of acute and nodular radiation-induced injury of the left liver after neo-adjuvant chemoradiotherapy for distal esophageal cancer, which resembles a hepatic metastasis on (18)FDG-PET/CT. Acute and nodular radiation hepatitis (RH) can be a potential cause of false-positive findings of malignancy and therefore exclude patients who could benefit from esophagectomy...
October 27, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27771590/decreased-resting-state-metabolic-activity-in-frontopolar-and-parietal-brain-regions-is-associated-with-suicide-plans-in-depressed-individuals
#12
Kees van Heeringen, Guo-Rong Wu, Myriam Vervaet, Marie-Anne Vanderhasselt, Chris Baeken
Suicide plans are a major risk factor for suicide, which is a devastating outcome of depression. While structural and functional brain changes have been demonstrated in relation to suicidal thoughts and behaviour, brain mechanisms underlying suicide plans have not yet been studied. Here, we studied changes in regional cerebral metabolic activity in association with suicide plans in depressed individuals. Using (18)FDG-PET, a comparative study of regional cerebral glucose metabolism (rCMRglu) was carried out in depressed individuals with suicidal thoughts and suicide plans, depressed individuals with only suicidal thoughts, depressed individuals without suicide thoughts and plans, and healthy controls...
October 19, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27742480/assessing-the-role-of-primary-tumour-resection-in-patients-with-synchronous-unresectable-liver-metastases-from-pancreatic-neuroendocrine-tumour-of-the-body-and-tail-a-propensity-score-survival-evaluation
#13
E Bertani, N Fazio, D Radice, C Zardini, G Spinoglio, A Chiappa, D Ribero, R Biffi, S Partelli, M Falconi
BACKGROUND: The role of primary tumour surgery in pancreatic neuroendocrine tumours (PNETs) with unresectable liver metastases is controversial and international guidelines do not recommend surgery in such cases. Resectability of the primary tumour has never been considered in outcome comparisons between operated and non-operated patients. METHODS: From two institutional prospective databases of patients affected by PNET and unresectable liver metastases, 63 patients who underwent a left-pancreatectomy at diagnosis were identified and compared with a group of 30 patients with a potentially resectable but not-resected primary tumour located in the body or tail...
September 30, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27742070/richter-s-syndrome-novel-and-promising-therapeutic-alternatives
#14
Davide Rossi
Richter's syndrome (RS) is the development of an aggressive lymphoma in patients with a previous or concomitant diagnosis of chronic lymphocytic leukemia (CLL). The incidence rate for RS is ∼0.5% per year of observation. In the presence of clinical suspicious of RS, diagnosis of transformation and choice of the site of biopsy may take advantage of (18)FDG PET/CT. Molecular lesions of tumor suppression regulators (TP53), cell cycle (CDKN2A) and cell proliferation (NOTCH1, MYC) overall account for ∼90% of RS and may be responsible for its aggressive clinical phenotype...
March 2016: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/27726929/contribution-of-18-fdg-pet-ct-to-brown-tumor-detection-in-a-patient-with-primary-hyperparathyroidism
#15
Mélanie Gahier Penhoat, Delphine Drui, Catherine Ansquer, Eric Mirallie, Yves Maugars, Pascale Guillot
We report the case of a patient who presented with multiple brown tumors as the inaugural manifestation of primary hyperparathyroidism. Tc-99m hexakis methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy demonstrated increased radiotracer uptake by the bone lesions. The patient was a 65-year-old male who sought advice for a swelling on his right shin. An osteolytic lesion was visible on the radiograph. A bone biopsy showed a benign tumor containing abundant osteoclastic cells. Laboratory abnormalities included hypercalcemia (3...
October 7, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27716085/clinical-significance-of-incidental-18%C3%A2-f-fdg-uptake-in-the-gastrointestinal-tract-on-pet-ct-imaging-a-retrospective-cohort-study
#16
Eugenia Shmidt, Vandana Nehra, Val Lowe, Amy S Oxentenko
BACKGROUND: The frequency and clinically important characteristics of incidental (18)F-fluorodeoxyglucose ([18 F]FDG) positron emission tomography (PET) uptake in the gastrointestinal tract (GIT) on PET/CT imaging in adults remain elusive. METHODS: All PET/CT reports from 1/1/2000 to 12/31/2009 at a single tertiary referral center were reviewed; clinical information was obtained from cases with incidental (18)F-FDG uptake in the GIT, with follow-up through October, 2012...
October 6, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27713140/neuroprotective-effects-of-cd4-cd25-foxp3-regulatory-t-cells-in-a-3xtg-ad-alzheimer-s-disease-model
#17
Hyunjung Baek, Minsook Ye, Geun-Hyung Kang, Chanju Lee, Gihyun Lee, Da Bin Choi, Jaehoon Jung, Hyunseong Kim, Seonhwa Lee, Jin Su Kim, Hyun-Ju Lee, Insop Shim, Jun-Ho Lee, Hyunsu Bae
Alzheimer's disease patients display neuropathological lesions, including the accumulation of amyloid-beta (Aβ) peptide and neurofibrillary tangles. Although the mechanisms causing the neurodegenerative process are largely unknown, increasing evidence highlights a critical role of immunity in the pathogenesis of Alzheimer's disease. In the present study, we investigated the role of regulatory T cells (Tregs) on Alzheimer's disease progression. First, we explored the effect of Tregs (CD4+CD25+ T cells) and Teffs (CD4+CD25- T cells) in an adoptive transfer model...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27692533/-18-fdg-pet-ct-improves-specificity-of-preoperative-lymph-node-staging-in-patients-with-intestinal-but-not-diffuse-type-esophagogastric-adenocarcinoma
#18
K Lehmann, D Eshmuminov, P Bauerfeind, C Gubler, P Veit-Haibach, A Weber, H Abdul-Rahman, M Fischer, C Reiner, P M Schneider
INTRODUCTION: The accuracy of preoperative lymph-node staging in patients with adenocarcinoma of the esophagogastric junction (AEG) or gastric cancer (GC) is low. The aim of this study was to assess the accuracy of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET-CT) for lymph-node staging in patients with AEG or GC, with or without neoadjuvant treatment. PATIENTS AND METHODS: 221 consecutive patients with GC (n = 88) or AEG (n = 133) were evaluated...
September 7, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27688946/concept-of-an-upright-wearable-positron-emission-tomography-imager-in-humans
#19
Christopher E Bauer, Julie Brefczynski-Lewis, Gary Marano, Mary-Beth Mandich, Alexander Stolin, Peter Martone, James W Lewis, Gangadhar Jaliparthi, Raymond R Raylman, Stan Majewski
BACKGROUND: Positron Emission Tomography (PET) is traditionally used to image patients in restrictive positions, with few devices allowing for upright, brain-dedicated imaging. Our team has explored the concept of wearable PET imagers which could provide functional brain imaging of freely moving subjects. To test feasibility and determine future considerations for development, we built a rudimentary proof-of-concept prototype (Helmet_PET) and conducted tests in phantoms and four human volunteers...
September 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27675823/improvement-of-target-definition-for-laryngeal-and-hypopharyngeal-cancer-on-computed-tomography-magnetic-resonance-imaging-and-18-fdg-positron-emission-tomography-validated-by-histopathology
#20
H Ligtenberg, E A Jager, J Caldas Magalhaes, T Schakel, N Kasperts, F A Pameijer, C Terhaard, L M Janssen, S M Willems, C P Raaijmakers, M Philippens
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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