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Preserved ejection fraction

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https://www.readbyqxmd.com/read/28741909/a-prospective-evaluation-of-the-established-criteria-for-heart-failure-with-preserved-ejection-fraction-using-the-alberta-heart-cohort
#1
Justin A Ezekowitz, Finlay A McAlister, Jonathan Howlett, Wendimagegn Alemayehu, Ian Paterson, Israel Belenkie, Gavin Y Oudit, Padma Kaul, Jason R Dyck, Todd Anderson
AIMS: Heart failure with a preserved ejection fraction (HF-PEF) remains a difficult clinical diagnosis. The aim of this study was to test the utility of established criteria to classify patients with HF-PEF. We prospectively enrolled patients into one of five groups across a spectrum of cardiac disease and applied three different criteria for HF-PEF and calculated diagnostic metrics. METHODS AND RESULTS: A total of 565 patients were included in the analysis, including 170 patients with an adjudicated diagnosis of HF-PEF, 152 patients with heart failure with reduced ejection fraction, 152 patients at risk for heart failure, and 91 age-matched healthy controls...
July 25, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28739614/apical-ballooning-takotsubo-syndrome-with-concurrent-st-segment-elevation-myocardial-infarction
#2
Mohsin A Hussain, Andrew T Cox, Rachel Bastiaenen, Abhiram Prasad
We present the case of a 61-year-old woman admitted with chest pain and an ECG demonstrating ST-segment elevation in the lateral leads. Emergency coronary angiography demonstrated an occluded obtuse marginal branch. Percutaneous intervention was unsuccessful as the lesion could not be crossed with a wire. Left ventriculography and transthoracic echocardiography demonstrated hypokinesis of the entire apex but preserved contractility of the basal segments, consistent with a diagnosis of apical ballooning syndrome (ABS)...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28738140/high-prevalence-of-subclinical-cerebral-infarction-in-patients-with-heart-failure-with-preserved-ejection-fraction
#3
Rebecca J Cogswell, Faye L Norby, Rebecca F Gottesman, Lin Y Chen, Scott Solomon, Amil Shah, Alvaro Alonso
AIMS: Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS: We studied 1527 participants in the Atherosclerosis Risk in Communities (ARIC) Study, who underwent echocardiography, brain magnetic resonance imaging (MRI) and detailed cognitive assessment during 2011-13...
July 24, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28736291/clinical-and-hemodynamic-correlates-and-prognostic-value-of-ve-vco2-slope-in-patients-with-heart-failure-with-preserved-ejection-fraction-and-pulmonary-hypertension
#4
Sebastiaan H C Klaassen, Licette C Y Liu, Yoran M Hummel, Kevin Damman, P van der Meer, Adriaan A Voors, Elke S Hoendermis, Dirk J van Veldhuisen
BACKGROUND: Impaired exercise capacity is one of the hallmarks of heart failure with preserved ejection fraction (HFpEF), but the clinical and hemodynamic correlates and prognostic value of exercise testing in patients with HFpEF is unknown. METHODS: Patients with HFpEF (Left ventricular ejection fraction [LVEF] ≥ 45%) and pulmonary hypertension, underwent cardiopulmonary exercise test (CPX) to measure maximal (peak VO2) and sub maximal (ventilatory equivalent for carbon dioxide [VE/VCO2] slope) exercise capacity...
July 20, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28734909/prognostic-value-of-exercise-stress-echocardiography-in-asymptomatic-patients-with-aortic-valve-stenosis
#5
Coppelia Goublaire, Maria Melissopoulou, David Lobo, Naozumi Kubota, Constance Verdonk, Claire Cimadevilla, Isabelle Codogno, Eric Brochet, Alec Vahanian, David Messika-Zeitoun
OBJECTIVES: This study sought to evaluate the prognostic value of mean pressure gradient (MPG) increase and peak systolic pulmonary artery pressure (SPAP) measured during exercise stress echocardiography in asymptomatic patients with aortic stenosis (AS). BACKGROUND: Exercise testing is recommended in asymptomatic AS patients, but the additional value of exercise-stress echocardiography, especially the prognostic value of MPG increase and peak SPAP, is still debated...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28733364/magnetic-resonance-imaging-of-myocardial-strain-after-acute-st-segment-elevation-myocardial-infarction-a-systematic-review
#6
Kenneth Mangion, Christie McComb, Daniel A Auger, Frederick H Epstein, Colin Berry
The purpose of this systematic review is to provide a clinically relevant, disease-based perspective on myocardial strain imaging in patients with acute myocardial infarction or stable ischemic heart disease. Cardiac magnetic resonance imaging uniquely integrates myocardial function with pathology. Therefore, this review focuses on strain imaging with cardiac magnetic resonance. We have specifically considered the relationships between left ventricular (LV) strain, infarct pathologies, and their associations with prognosis...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28730869/impact-of-iron-deficiency-on-exercise-capacity-and-outcome-in-heart-failure-with-reduced-mid-range-and-preserved-ejection-fraction
#7
Pieter Martens, Petra Nijst, Frederik H Verbrugge, Kevin Smeets, Matthias Dupont, Wilfried Mullens
BACKGROUND: Little information is available about the prevalence and impact on exercise capacity and outcome of iron deficiency in heart failure with mid-range (HFmrEF) and preserved (HFpEF) ejection fraction in comparison to heart failure with reduced ejection-fraction (HFrEF). Furthermore, no data is available about the progression of ID in patients without baseline anaemia. METHODS: We evaluated baseline iron and haemoglobin-status in a single-centre, prospective heart failure database...
July 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28725953/prognostic-significance-of-low-systolic-blood-pressure-at-discharge-in-patients-with-heart-failure-and-preserved-ejection-fraction
#8
Shijun Li, Xiaoying Li
INTRODUCTION: Systolic blood pressure (SBP) is emerging as a predictor of outcome in chronic heart failure and low SBP has been shown to be related to higher mortality. AIM: To investigate the relationship between low SBP and long-term outcome in patients with heart failure with preserved ejection fraction (HFpEF). METHODS: We use prospectively collected data and recruited 297 patients with chronic HFpEF to investigate the relationship between low SBP at discharge and long-term outcome...
July 19, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28724945/effect-of-septal-flash-on-right-ventricular-systolic-function-in-left-bundle-branch-block-patients-with-preserved-left-ventricular-ejection-fraction
#9
Guang-Yuan Li, Yong-Huai Wang, Zheng-Yu Guan, Xuan-Yi Jin, Yang Li, Shuang Liu, Chun-Yan Ma, Jun Yang
A leftward motion of the ventricular septum prior to ejection, known as the septal flash (SF), is frequently observed in patients with left bundle-branch block (LBBB). We investigated whether the abnormal motion of the ventricular septum affects right ventricle (RV) contractile performance in LBBB patients with preserved left ventricular ejection fraction (LVEF). Forty-four patients with complete LBBB were selected using standard 12-lead electrocardiograms (ECGs), with 30 healthy individuals serving as controls...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716687/measures-of-ventricular-arterial-coupling-and-incident-heart-failure-preserved-ejection-fraction-hfpef-a-matched-case-control-analysis
#10
Carolyn L Lekavich, Debra J Barksdale, Jia-Rong Wu, Virginia Neelon, Jamie Crandell, Eric J Velazquez
OBJECTIVES: This study was designed to detect differences in markers associated with incident heart failure preserved ejection fraction (HFpEF) when comparing matched case-control groups. BACKGROUND: Evidence continues to demonstrate increasing prevalence, cost and mortality implications of HFpEF, but clearly defined parameters that distinguish between controls and HFpEF have not been established. METHODS: A study cohort of case (incident patients with HFpEF, n=155) and matched control (patients with no prior HF, n=155) groups was retrospectively identified...
July 14, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28714796/effect-of-bariatric-surgery-on-heart-failure
#11
Marcela Rodriguez Flores, Carlos Aguilar Salinas, Marie-Eve Piché, Audrey Auclair, Paul Poirier
Obesity increases the risk of heart failure (HF), which continues to be a significant proportion of all cardiovascular diseases and affects increasingly younger populations. The cross-talk between adipose and the heart involves insulin resistance, adipokine signaling and inflammation, with the capacity of adipose tissue to mediate hemodynamic signals, promoting progressive cardiomyopathy. Areas covered: From a therapeutic perspective, there is not yet a single obesity-related pathway that when addressed, can ameliorate cardiomyopathy in obese patients and this is a matter of ongoing research...
July 17, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28712998/brain-natriuretic-peptide-mediates-the-prognostic-role-of-renal-function-towards-10-year-cardiovascular-mortality-in-patients-with-acute-coronary-syndrome-the-hhf-study-2006-2016
#12
Christina Chrysohoou, George Georgiopoulos, Hara Kosyfa, Ioanna Kotsopoulou Haritou, Matina Kouvari, Androniki Filippou, Stelios Iosifidis, Eleftherios Tsiamis, Panagiotis Aggelopoulos, Christos Pitsavos, Dimitris Tousoulis
BACKGROUND/INTRODUCTION: Risk stratification in chronic heart failure (HF) remains a challenge. Renal function and B-natriuretic peptide (BNP) might confer predictive value towards long-term mortality in HF patients after an acute coronary syndrome (ACS). METHODS: From May 2006 to March 2009, 1,000 consecutive patients who were hospitalized with ACS diagnosis were enrolled in the study. In 2016, the 10-year follow-up (2006-2016) was performed in 745 participants...
July 13, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28712069/left-atrial-dysfunction-as-a-determinant-of-pulmonary-hypertension-in-patients-with-severe-aortic-stenosis-and-preserved-left-ventricular-ejection-fraction
#13
Andreea Calin, Anca D Mateescu, Monica Rosca, Carmen C Beladan, Roxana Enache, Simona Botezatu, Iulian Cosei, Cosmin Calin, Marian Simion, Carmen Ginghina, Andreea C Popescu, Bogdan A Popescu
In patients with severe aortic stenosis (AS), the presence of pulmonary hypertension (PH) has been linked to a poor prognosis. We aimed to assess the main determinants of PH in patients with severe AS and preserved left ventricular ejection fraction (LVEF). We prospectively enrolled 108 consecutive patients with isolated severe AS (indexed aortic valve area <0.6 cm(2)/m(2)) and LVEF >50%, in sinus rhythm. Left atrial (LA) function was assessed using longitudinal deformation parameters (by speckle tracking echocardiography)...
July 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28711451/atrial-fibrillation-in-heart-failure-with-preserved-mid-range-and-reduced-ejection-fraction
#14
Ulrik Sartipy, Ulf Dahlström, Michael Fu, Lars H Lund
OBJECTIVES: The study sought to assess the independent risk factors for, consequences of, and outcomes with atrial fibrillation (AF) compared with sinus rhythm (SR) in heart failure (HF) with preserved ejection fraction (HFpEF) versus HF with mid-range ejection fraction (HFmrEF) versus HF with reduced ejection fraction (HFrEF). BACKGROUND: AF is common in HF, but most data are from HFrEF. The importance of AF in HFpEF and MFmrEF is less well known. METHODS: In patients from 2000 to 2012 in the SwedeHF (Swedish Heart Failure Registry) registry, enriched with patient-level data from national health care registries, the authors assessed prevalence of, associations with and prognostic impact of AF in HFpEF versus HFmrEF versus HFrEF...
July 6, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28711449/intrarenal-flow-alterations-during-transition-from-euvolemia-to-intravascular-volume-expansion-in-heart-failure-patients
#15
Petra Nijst, Pieter Martens, Matthias Dupont, W H Wilson Tang, Wilfried Mullens
OBJECTIVES: The goal of this study was to assess: 1) the intrarenal flow in heart failure (HF) patients during the transition from euvolemia to intravascular volume overload; and 2) the relationship between intrarenal flow and diuretic efficiency. BACKGROUND: Intrarenal blood flow alterations may help to better understand impaired volume handling in HF. METHODS: Resistance index (RI) and venous impedance index (VII) were assessed in 6 healthy subjects, 40 euvolemic HF patients with reduced ejection fraction (HFrEF) and 10 HF patients with preserved ejection fraction (HFpEF)...
July 6, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28711447/the-transition-from-hypertension-to%C3%A2-heart%C3%A2-failure-contemporary-update
#16
REVIEW
Franz H Messerli, Stefano F Rimoldi, Sripal Bangalore
Longstanding hypertension ultimately leads to heart failure (HF), and as a consequence most patients with HF have a history of hypertension. Conversely, absence of hypertension in middle age is associated with lower risks for incident HF across the remaining life course. Cardiac remodeling to a predominant pressure overload consists of diastolic dysfunction and concentric left ventricular (LV) hypertrophy. When pressure overload is sustained, diastolic dysfunction progresses, filling of the concentric remodeled LV decreases, and HF with preserved ejection fraction ensues...
July 6, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28707730/complement-and-contact-system-activation-in-acute-congestive-heart-failure-patients
#17
Chiara Suffritti, Eleonora Tobaldini, Riccardo Schiavon, Silvia Strada, Lorena Maggioni, Satish Mehta, Giulia Sandrone, Edgar Toschi-Dias, Marco Cicardi, Nicola Montano
BACKGROUND: Recent experimental data indicate a pathogenic role of complement activation in congestive heart failure (CHF). Aim of this study was to evaluate contact and complement systems activation in patients hospitalized for an acute episode of CHF. METHODS AND RESULTS: 42 of 80 consecutive patients admitted at our hospital with confirmed diagnosis of acute CHF were enrolled. They underwent blood sampling within 24 hours from admission (T0) and at clinical stability (T1)...
July 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28706743/when-is-the-optimal-timing-of-surgical-intervention-for-severe-functional-tricuspid-regurgitation
#18
Nobuhiro Nakanishi, Masanobu Ishii, Koichi Kaikita, Ken Okamoto, Yasuhiro Izumiya, Eiichiro Yamamoto, Seiji Takashio, Seiji Hokimoto, Toshihiro Fukui, Kenichi Tsujita
Functional tricuspid regurgitation (TR) is a serious pathology to be noted for severe right heart failure (HF) and poor prognosis; however, the conventional assessment of TR has some limitations and the optimal timing of surgical intervention remains unclear. A 79-year-old Japanese female was admitted to our hospital to undergo cardiac surgery, because edema gradually got worse despite the increase in diuretics. She had a history of atrial fibrillation (AF) and chronic HF due to severe TR and had been treated with a furosemide for leg edema 4 years ago...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28706575/targeting-endothelial-function-to-treat-heart-failure-with-preserved-ejection-fraction-the-promise-of-exercise-training
#19
REVIEW
Andreas B Gevaert, Katrien Lemmens, Christiaan J Vrints, Emeline M Van Craenenbroeck
Although the burden of heart failure with preserved ejection fraction (HFpEF) is increasing, there is no therapy available that improves prognosis. Clinical trials using beta blockers and angiotensin converting enzyme inhibitors, cardiac-targeting drugs that reduce mortality in heart failure with reduced ejection fraction (HFrEF), have had disappointing results in HFpEF patients. A new "whole-systems" approach has been proposed for designing future HFpEF therapies, moving focus from the cardiomyocyte to the endothelium...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28705911/making-the-case-for-skeletal-muscle-myopathy-and-its-contribution-to-exercise-intolerance-in-heart-failure-with-preserved-ejection-fraction
#20
EDITORIAL
Dalane W Kitzman, Mark J Haykowsky, Corey R Tomczak
No abstract text is available yet for this article.
July 2017: Circulation. Heart Failure
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