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https://www.readbyqxmd.com/read/28086751/quantifying-predictors-for-the-spatial-diffusion-of-avian-influenza-virus-in-china
#1
Lu Lu, Andrew J Leigh Brown, Samantha J Lycett
BACKGROUND: Avian influenza virus (AIV) causes both severe outbreaks and endemic disease among poultry and has caused sporadic human infections in Asia, furthermore the routes of transmission in avian species between geographic regions can be numerous and complex. Using nucleotide sequences from the internal protein coding segments of AIV, we performed a Bayesian phylogeographic study to uncover regional routes of transmission and factors predictive of the rate of viral diffusion within China...
January 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28081470/inhibition-viral-rnp-and-anti-inflammatory-activity-of-coumarins-against-influenza-virus
#2
YuTao Wang, Wen Yan, QiaoLian Chen, WanYi Huang, Zifeng Yang, Xiong Li, XinHua Wang
Influenza viruses pose a severe threat to human health and a significant increase in antiviral drug-resistant among influenza viruses worldwide has been observed. Therefore, there is an urgent need to develop the new antiviral drugs, specifically from the natural products. In this study, the anti-viral and anti-inflammatory activities of coumarins against influenza A virus in vitro were investigated. One of the derivatives eleutheroside B1 showed a wide spectrum of anti- human influenza virus effect with the IC50 value of 64-125μg/ml in vitro, but it showed no effects against avian influenza virus...
January 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28079520/genetic-characterisation-of-novel-highly-pathogenic-avian-influenza-hpai-h5n6-viruses-isolated-in-birds-south-korea-november-2016
#3
Young-Jae Si, In Won Lee, Eun-Ha Kim, Young-Il Kim, Hyeok-Il Kwon, Su-Jin Park, Hiep Dinh Nguyen, Se Mi Kim, Jin-Jung Kwon, Won-Suk Choi, Yun Hee Beak, Min-Suk Song, Chul-Joong Kim, Richard J Webby, Young-Ki Choi
A novel genotype of H5N6 influenza viruses was isolated from migratory birds in South Korea during November 2016. Domestic outbreaks of this virus were associated with die-offs of wild birds near reported poultry cases in Chungbuk province, central South Korea. Genetic analysis and animal studies demonstrated that the Korean H5N6 viruses are highly pathogenic avian influenza (HPAI) viruses and that these viruses are novel reassortants of at least three different subtypes (H5N6, H4N2 and H1N1).
January 5, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28079188/proteome-response-of-chicken-embryo-fibroblast-cells-to-recombinant-h5n1-avian-influenza-viruses-with-different-neuraminidase-stalk-lengths
#4
Yongtao Li, Fan Ming, Huimin Huang, Kelei Guo, Huanchun Chen, Meilin Jin, Hongbo Zhou
The variation on neuraminidase (NA) stalk region of highly pathogenic avian influenza H5N1 virus results in virulence change in animals. In our previous studies, the special NA stalk-motif of H5N1 viruses has been demonstrated to play a significant role in the high virulence and pathogenicity in chickens. However, the molecular mechanisms underlying the pathogenicity of viruses with different NA stalk remain poorly understood. This study presents a comprehensive characterization of the proteome response of chicken cells to recombinant H5N1 virus with stalk-short NA (rNA-wt) and the stalkless NA mutant virus (rSD20)...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077631/vaccine-efficacy-of-an-inactivated-chimeric-ha-h9-h5n2-avian-influenza-virus-and-its-suitability-for-the-marker-vaccine-strategy
#5
Se Mi Kim, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Hyeok-Il Kwon, Young-Jae Si, In-Won Lee, Min-Suk Song, Young Ki Choi
: In order to produce a dual effective vaccine against H9 and H5 avian influenza viruses that aligns with the DIVA (differentiating infected from vaccinated animals) strategy, we generated a chimeric H9/H5N2 recombinant vaccine which expressed the whole HA1 region of A/CK/Korea/04163/04 H9N2 and HA2 region of recent HPAI A/MD/Korea/W452/14 H5N8 viruses. The Chimeric H9/H5N2 virus showed similar in vitro and in vivo growth properties and virulence to the LPAI H9 influenza virus. An inactivated vaccine based on this chimeric virus induced serum neutralizing (SN) antibodies against both H9 and H5 viruses, but only induced cross-reactive hemmaglutination inhibition (HI) antibody against H9 viruses...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28072964/-avian-influenza-virus-h9n2-found-in-a-child-with-influenza-like-illness-in-beijing
#6
R N Zhu, Y Sun, F Wang
No abstract text is available yet for this article.
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28065477/quantitative-analysis-of-the-yield-of-avian-h7-influenza-virus-haemagglutinin-protein-produced-in-silkworm-pupae-with-the-use-of-the-codon-optimized-dna-a-possible-oral-vaccine
#7
Kuniaki Nerome, Sayaka Matsuda, Kenichi Maegawa, Shigeo Sugita, Kazumichi Kuroda, Kazunori Kawasaki, Reiko Nerome
In this study, we aimed to quantitatively compare the increased production of three H7 influenza virus-like particle (VLP) haemagglutinin (HA) with the use of a codon-optimized single HA gene in silkworm pupae. Recombinant baculovirus (Korea H7-BmNPV) could produce 0.40 million HA units per pupa, corresponding to 1832μg protein. The yield of the HA produced in larva was estimated to be approximately 0.31 million HA units per larva, and there were no significant differences between the three HA proteins. We could establish efficient recovery system of HA production in larvae and pupae with the use of three cycles sonication methods...
January 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28063705/h9n2-avian-influenza-virus-enhances-the-immune-responses-of-bmdcs-by-down-regulating-mir29c
#8
Jian Lin, Jing Xia, Ya T Chen, Ke Y Zhang, Yan Zeng, Qian Yang
Avian influenza virus (AIV) of the subtypes H9 and N2 is well recognised and caused outbreaks-due to its high genetic variability and high rate of recombination with other influenza virus subtypes. The pathogenicity of H9N2 AIV depends on the host immune response. Dendritic cells (DCs) are major antigen presenting cells that can significantly inhibit H9N2 AIV replication. MicroRNAs (miRNAs) influence the ability of DCs to present antigens, as well as the ability of AIVs to infect host cells and replicate. Here, we studied the molecular mechanism underlying the miRNA-mediated regulation of immune function of mouse DCs...
January 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28062760/oie-avian-influenza-portal
#9
(no author information available yet)
No abstract text is available yet for this article.
January 7, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28062701/widespread-virus-replication-in-alveoli-drives-acute-respiratory-distress-syndrome-in-aerosolized-h5n1-influenza-infection-of-macaques
#10
Elizabeth R Wonderlich, Zachary D Swan, Stephanie J Bissel, Amy L Hartman, Jonathan P Carney, Katherine J O'Malley, Adebimpe O Obadan, Jefferson Santos, Reagan Walker, Timothy J Sturgeon, Lonnie J Frye, Pauline Maiello, Charles A Scanga, Jennifer D Bowling, Anthea L Bouwer, Parichat A Duangkhae, Clayton A Wiley, JoAnne L Flynn, Jieru Wang, Kelly S Cole, Daniel R Perez, Douglas S Reed, Simon M Barratt-Boyes
Human infections with highly pathogenic avian influenza A (H5N1) virus are frequently fatal but the mechanisms of disease remain ill-defined. H5N1 infection is associated with intense production of proinflammatory cytokines, but whether this cytokine storm is the main cause of fatality or is a consequence of extensive virus replication that itself drives disease remains controversial. Conventional intratracheal inoculation of a liquid suspension of H5N1 influenza virus in nonhuman primates likely results in efficient clearance of virus within the upper respiratory tract and rarely produces severe disease...
January 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28062014/novel-variants-of-clade-2-3-2-1-h5n1-highly-pathogenic-avian-influenza-virus-in-migratory-waterfowl-of-hongze-lake
#11
Wenming Jiang, Guangyu Hou, Jinping Li, Cheng Peng, Suchun Wang, Jiming Chen
Wild birds are known to play a major role in the evolution, maintenance, and spread of the avian influenza viruses (AIVs). More specifically, the waterfowl are thought to be the natural reservoirs of AIVs. Here, we conducted a survey in 2015 at the Hongze Lake and characterized 11 H5N1 highly pathogenic AIVs isolated from wild waterfowls which were found to belong to clade 2.3.2.1. In contrast, the 11 variants of H5N1 viruses did not align with the three previously defined monophyletic subclades. Antigenicity analysis revealed that antigenic drift occurred in these H5N1 variants...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28062008/experimental-infection-of-mandarin-duck-with-highly-pathogenic-avian-influenza-a-h5n8-and-h5n1-viruses
#12
Hyun-Mi Kang, Eun-Kyoung Lee, Byung-Min Song, Gyeong-Beom Heo, Joojin Jung, Il Jang, You-Chan Bae, Suk Chan Jung, Youn-Jeong Lee
A highly pathogenic avian influenza (HPAI) H5N8 virus was first detected in poultry and wild birds in South Korea in January 2014. Here, we determined the pathogenicity and transmissibility of three different clades of H5 viruses in mandarin ducks to examine the potential for wild bird infection. H5N8 (clade 2.3.4.4) replicated more efficiently in the upper and lower respiratory tract of mandarin ducks than two previously identified H5N1 virus clades (clades 2.2 and 2.3.2.1). However, none of the mandarin ducks infected with H5N8 and H5N1 viruses showed severe clinical signs or mortality, and gross lesions were only observed in a few tissues...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28061848/multi-antigen-avian-influenza-a-h7n9-virus-like-particles-particulate-characterizations-and-immunogenicity-evaluation-in-murine-and-avian-models
#13
Che-Ming Jack Hu, Chu-Yang Chien, Ming-Tsan Liu, Zih-Syun Fang, Sui-Yuan Chang, Rong-Huay Juang, Shih-Chung Chang, Hui-Wen Chen
BACKGROUND: Human infection with avian influenza A virus (H7N9) was first reported in China in March 2013. Since then, hundreds of cases have been confirmed showing severe symptoms with a high mortality rate. The virus was transmitted from avian species to humans and has spread to many neighboring areas, raising serious concerns over its pandemic potential. Towards containing the disease, the goal of this study is to prepare a virus-like particle (VLP) that consists of hemagglutinin (HA), neuraminidase (NA) and matrix protein 1 (M1) derived from the human isolate A/Taiwan/S02076/2013(H7N9) for potential vaccine development...
January 7, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28061784/inhibition-of-influenza-virus-via-a-sesquiterpene-fraction-isolated-from-laggera-pterodonta-by-targeting-the-nf-%C3%AE%C2%BAb-and-p38-pathways
#14
YuTao Wang, Beixian Zhou, Jingguang Lu, QiaoLian Chen, Huihui Ti, WanYi Huang, Jing Li, ZiFeng Yang, Zhihong Jiang, XinHua Wang
BACKGROUND: Influenza virus poses serious threats to human health, especially human infection with avian influenza virus. Laggera pterodonta (DC.) Benth is a medicinal plant that is widely used in Traditional Chinese Medicine, especially in Yunnan province, and has been used to treat influenza, pharyngolaryngitis, and bronchitis. However, the compound(s) responsible for the activity and their mechanisms of action against the influenza virus remain to be elucidated. METHODS: L...
January 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28057259/modified-vaccinia-virus-ankara-history-value-in-basic-research-and-current-perspectives-for-vaccine-development
#15
A Volz, G Sutter
Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation vaccine against smallpox and serves as a potent vector system for development of new candidate vaccines against infectious diseases and cancer. Historically, MVA was developed by serial tissue culture passage in primary chicken cells of vaccinia virus strain Ankara, and clinically used to avoid the undesirable side effects of conventional smallpox vaccination. Adapted to growth in avian cells MVA lost the ability to replicate in mammalian hosts and lacks many of the genes orthopoxviruses use to conquer their host (cell) environment...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28057141/-research-on-spatiotemporal-spread-of-avian-influenza-a-h7n9-virus-based-on-discrete-geographic-information
#16
M X Wang, M Q Yuan, Y Fang
Objective: To establish a dynamic spatiotemporal spread modes of influenza A (H7N9) virus by using discrete geographic information and explore the spatiotemporal transmission of the virus. Methods: The gene sequences of H7N9 virus isolated from human in China, which were available from Global Initiative on Sharing Avian Influenza Data (GISAID), were used in alignment by using software BioEdit 7.0. Spatiotemporal spread model of H7N9 virus was established in a Bayesian statistical framework by using software BEAST 1...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28057117/-molecular-analysis-of-hemagglutinin-and-neuraminidase-genes-of-avian-influenza-virus-h5n6-subtype-in-the-border-of-yunnan-province-from-2014-to-2015
#17
Q Kong, H Y Zhao, K Tian, B F Duan, Y Y Hu, T S Hu, Y G Zhang, W D Zhang, F Q Zhang
No abstract text is available yet for this article.
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28054599/estimating-risks-of-inapparent-avian-exposure-for-human-infection-avian-influenza-virus-a-h7n9-in-zhejiang-province-china
#18
Erjia Ge, Renjie Zhang, Dengkui Li, Xiaolin Wei, Xiaomeng Wang, Poh-Chin Lai
Inapparent avian exposure was suspected for the sporadic infection of avian influenza A(H7N9) occurring in China. This type of exposure is usually unnoticed and difficult to model and measure. Infected poultry with avian influenza H7N9 virus typically remains asymptomatic, which may facilitate infection through inapparent poultry/bird exposure, especially in a country with widespread practice of backyard poultry. The present study proposed a novel approach that integrated ecological and case-control methods to quantify the risk of inapparent avian exposure on human H7N9 infection...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28051568/influenza-a-virus-surveillance-in-underrepresented-avian-species-in-ohio-in-2015
#19
Hannah E Urig, Jacqueline M Nolting, Dimitria A Mathys, Blake A Mathys, Andrew S Bowman
We surveyed passerines and other terrestrial avian species for influenza A virus, resulting in molecular detection of virus from 1.5% of the 615 birds. However, no viral isolates were recovered. Little is known about the role that these undersurveilled avian species play in the ecology of influenza A virus.
January 4, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28038412/enhanced-virulence-of-clade-2-3-2-1-highly-pathogenic-avian-influenza-a-h5n1-viruses-in-ferrets
#20
Melissa B Pearce, Claudia Pappas, Kortney M Gustin, C Todd Davis, Mary J Pantin-Jackwood, David E Swayne, Taronna R Maines, Jessica A Belser, Terrence M Tumpey
Sporadic avian to human transmission of highly pathogenic avian influenza (HPAI) A(H5N1) viruses necessitates the analysis of currently circulating and evolving clades to assess their potential risk. Following the spread and sustained circulation of clade 2 viruses across multiple continents, numerous subclades and genotypes have been described. To better understand the pathogenesis associated with the continued diversification of clade 2A(H5N1) influenza viruses, we investigated the relative virulence of eleven human and poultry isolates collected from 2006 to 2013 by determining their ability to cause disease in the ferret model...
December 27, 2016: Virology
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