Ziying Lei, Xiaohong Xia, Qiaoling He, Jiali Luo, Yan Xiong, Jin Wang, Hongsheng Tang, Tianpei Guan, Yun Tian, Songhui Xu, Shuzhong Cui
Gastric cancer (GC) has one of the highest tumor incidences worldwide. Heat shock protein 70 (HSP70) is highly expressed and plays a critical role in the occurrence, progression, metastasis, poor prognosis, and drug resistance of GC. However, the underlying mechanisms of HSP70 are not clear. To explore the regulatory role of HSP70 in GC, we performed cell counting kit-8 (CCK-8) and EdU staining assays to assess cell proliferation; immunohistochemistry and western blot analyses to assess protein expression; coimmunoprecipitation (Co-IP) assays to assess interactions between two proteins; and immunofluorescence to assess protein expression and localization...
December 2021: Molecular Carcinogenesis