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https://www.readbyqxmd.com/read/27902420/interleukin-1-receptor-antagonist-il-1ra-an-early-immunomodulatory-cytokine-induced-by-porcine-reproductive-and-respiratory-syndrome-virus-prrsv
#1
Teerawut Nedumpun, Piya Wongyanin, Chaitawat Sirisereewan, Patcharee Ritprajuk, Tanapat Palaga, Roongroje Thanawongnuwech, Sanipa Suradhat
Porcine reproductive and respiratory syndrome virus (PRRSV) infection poorly induces pro-inflammatory cytokines (IL-1, IL-6, TNF-α) and type I IFN production during the early phase of infection. Our microarray analysis indicated strong upregulation of the IL1RA gene in type 2 PRRSV infected monocyte-derived dendritic cells (MoDC). Interleukin-1 receptor antagonist (IL-1Ra) is an early inhibitory cytokine, which suppresses pro-inflammatory cytokines and T lymphocyte responses. To investigate the induction of IL-1Ra by PRRSV, MoDC were cultured with type 2 PRRSV or other swine viruses...
November 23, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27530458/protection-of-atlantic-salmon-against-salmonid-alphavirus-infection-by-type-i-interferons-ifna-ifnb-and-ifnc
#2
Chia-Jung Chang, Iris Jenssen, Børre Robertsen
Salmonid alphavirus 3 (SAV3) causes pancreas disease (PD), which is a major problem in Norwegian aquaculture of Atlantic salmon. In this work we studied antiviral activities of salmon type I interferons IFNa, IFNb and IFNc against SAV3 infection in cell culture and in live fish to increase the understanding of the innate immunity of salmon against this virus. Recombinant IFNa, IFNb and IFNc all induced antiviral activity against SAV3 in ASK cells. For in vivo studies, we injected salmon presmolts intramuscularly with plasmids encoding salmon IFNa, IFNb and IFNc or a control plasmid and measured expression of the antiviral protein Mx in pancreas after 2 and 10 weeks and protection against SAV3 infection after 10 weeks...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27522115/human-effector-b-lymphocytes-express-arid3a-and-secrete-interferon-alpha
#3
Julie M Ward, Michelle L Ratliff, Mikhail G Dozmorov, Graham Wiley, Joel M Guthridge, Patrick M Gaffney, Judith A James, Carol F Webb
Previously, we determined that enhanced disease activity in patients with systemic lupus erythematosus (SLE) was associated with dramatic increases in numbers of B lymphocytes expressing the transcription factor ARID3a. Our data now indicate ARID3a is important for interferon alpha (IFNa) expression and show a strong association between ARID3a expression and transcription of genes associated with lupus IFN signatures. Furthermore, both ARID3a and IFNa production were elicited in healthy control B cells upon stimulation with the TLR 9 agonist, CpG...
December 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27396621/drug-repurposing-of-minocycline-against-dengue-virus-infection
#4
Shilpa Lekshmi Leela, Chatchawan Srisawat, Gopinathan Pillai Sreekanth, Sansanee Noisakran, Pa-Thai Yenchitsomanus, Thawornchai Limjindaporn
Dengue virus infection is one of the most common arthropod-borne viral diseases. A complex interplay between host and viral factors contributes to the severity of infection. The antiviral effects of three antibiotics, lomefloxacin, netilmicin, and minocycline, were examined in this study, and minocycline was found to be a promising drug. This antiviral effect was confirmed in all four serotypes of the virus. The effects of minocycline at various stages of the viral life cycle, such as during viral RNA synthesis, intracellular envelope protein expression, and the production of infectious virions, were examined and found to be significantly reduced by minocycline treatment...
September 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27234230/long-term-efficacy-and-safety-of-interferon-%C3%AE-2a-therapy-in-severe-refractory-ophthalmic-behcet-s-disease
#5
Hadise Kavandi, Alireza Khabbazi, Sousan Kolahi, Mehrzad Hajialilo, Farid Karkon Shayan, Mohammad Oliaei
Ophthalmic involvement is the most debilitating complication of Behcet's disease (BD). The aim of the current study is to report on the efficacy and safety of a long-term use of interferon alpha-2a (IFNα-2a) in the treatment of refractory ophthalmic BD in the Azari population of Iran. We retrospectively analyzed the clinical data of 12 patients with ophthalmic BD who were under IFNα-2a therapy. All these patients had previously been treated unsuccessfully with corticosteroid and at least one conventional immunosuppressive drug...
May 27, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27192830/-forced-oscillations-of-dna-bases
#6
L V Yakushevich, L A Krasnobaeva
This paper presents the results of the studying of forced angular oscillations of the DNA bases with the help of the mathematical model consisting of two coupled nonlinear differential equations that take into account the effects of dissipation and the influence of an external periodic field. The calculation results are illustrated for sequence of gene encoding interferon alpha 17 (IFNA 17).
March 2016: Biofizika
https://www.readbyqxmd.com/read/27157597/ifna-of-triploid-hybrid-of-gold-fish-and-allotetraploid-is-an-antiviral-cytokine-against-svcv-and-gcrv
#7
Jun Yan, Lingzhi Peng, Yang Li, Hui Fan, Yu Tian, Shaojun Liu, Hao Feng
Triploid hybrid of gold fish (Carassius auratus red var., ♀, 2n = 100) and allotetroploid (♂, 2n = 100) displays much improved disease resistance than its parents. In this paper, one of the type I IFNs of triploid hybrid (3nIFNa) has been cloned and characterized. The full-length cDNA of 3nIFNa consists of 740 nucleotides and the predicted 3nIFNa protein contains 183 amino acids. The mRNA transcription of 3nIFNa was detected in all the selected tissues of triploid hybrid and was obviously enhanced after SVCV or GCRV infection...
July 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27135045/cytokine-stimulated-phosphoflow-of-whole-blood-using-cytof-mass-cytometry
#8
Rosemary Fernandez, Holden Maecker
The ability to assess the function of a range of cytokine, antigen receptor, and Toll-like receptor (TLR) signaling pathways in a range of immune cells could provide a kind of fingerprint of the state of the human immune system. The mass cytometry or CyTOF, platform allows for the parallel application of about 40 labeled antibodies to a single sample, creating the possibility to read out many cell types and signaling pathways in a single small blood sample. We developed such a mass cytometry panel, consisting of 22 antibodies to cell surface lineage markers and 8 antibodies to phospho-specific epitopes of signaling proteins...
June 5, 2015: Bio-protocol
https://www.readbyqxmd.com/read/27108379/ifn-adjuvanted-dna-vaccine-against-infectious-salmon-anemia-virus-antibody-kinetics-and-longevity-of-ifn-expression
#9
Børre Robertsen, Chia-Jung Chang, Lisa Bratland
Plasmids expressing interferon (IFN) have recently been shown to function as adjuvants in Atlantic salmon when co-injected with a DNA vaccine encoding hemagglutinin-esterase (HE) from infectious salmon anemia virus (ISAV). In this work we have compared the antibody kinetics and the systemic Mx/ISG15 response of fish vaccinated with HE-plasmid using either IFNa plasmid (pIFNa) or pIFNc as adjuvants over a longer time period, i.e. 22 weeks post vaccination (pv). The results showed that the antibody response against ISAV with pIFNa as adjuvant arose earlier (7 weeks pv) than with pIFNc as adjuvant (10 weeks pv), peaked at week 10 and declined at week 22...
July 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27095787/interferon-%C3%AE-signaling-promotes-embryonic-hsc-maturation
#10
Peter Geon Kim, Matthew C Canver, Catherine Rhee, Samantha J Ross, June V Harriss, Ho-Chou Tu, Stuart H Orkin, Haley O Tucker, George Q Daley
In the developing mouse embryo, the first hematopoietic stem cells (HSCs) arise in the aorta-gonad-mesonephros (AGM) and mature as they transit through the fetal liver (FL). Compared with FL and adult HSCs, AGM HSCs have reduced repopulation potential in irradiated adult transplant recipients but mechanisms underlying this deficiency in AGM HSCs are poorly understood. By co-expression gene network analysis, we deduced that AGM HSCs show lower levels of interferon-α (IFN-α)/Jak-Stat1-associated gene expression than FL HSCs...
July 14, 2016: Blood
https://www.readbyqxmd.com/read/27071061/genome-wide-host-gene-expression-analysis-in-chicken-lungs-infected-with-avian-influenza-viruses
#11
Pradip B Ranaware, Anamika Mishra, Periyasamy Vijayakumar, Pradeep N Gandhale, Himanshu Kumar, Diwakar D Kulkarni, Ashwin Ashok Raut
The molecular pathogenesis of avian influenza infection varies greatly with individual bird species and virus strain. The molecular pathogenesis of the highly pathogenic avian influenza virus (HPAIV) or the low pathogenic avian influenza virus (LPAIV) infection in avian species remains poorly understood. Thus, global immune response of chickens infected with HPAI H5N1 (A/duck/India/02CA10/2011) and LPAI H9N2 (A/duck/India/249800/2010) viruses was studied using microarray to identify crucial host genetic components responsive to these infection...
2016: PloS One
https://www.readbyqxmd.com/read/26529416/interferon-%C3%AE-subtypes-in-an-ex-vivo-model-of-acute-hiv-1-infection-expression-potency-and-effector-mechanisms
#12
Michael S Harper, Kejun Guo, Kathrin Gibbert, Eric J Lee, Stephanie M Dillon, Bradley S Barrett, Martin D McCarter, Kim J Hasenkrug, Ulf Dittmer, Cara C Wilson, Mario L Santiago
HIV-1 is transmitted primarily across mucosal surfaces and rapidly spreads within the intestinal mucosa during acute infection. The type I interferons (IFNs) likely serve as a first line of defense, but the relative expression and antiviral properties of the 12 IFNα subtypes against HIV-1 infection of mucosal tissues remain unknown. Here, we evaluated the expression of all IFNα subtypes in HIV-1-exposed plasmacytoid dendritic cells by next-generation sequencing. We then determined the relative antiviral potency of each IFNα subtype ex vivo using the human intestinal Lamina Propria Aggregate Culture model...
2015: PLoS Pathogens
https://www.readbyqxmd.com/read/26524356/-antiviral-treatment-and-long-term-clinical-outcome-of-decompensated-cirrhotic-patients-with-hepatitis-c-virus-infection
#13
Fanpu Ji, Shuangsuo Dang, Zhifang Cai, Hongan Xue, Na Huang, Layang Liu, Shu Zhang, Yonghong Guo, Xiaoli Jia, Yuan Wang, Zongfang Li, Hong Deng
OBJECTIVE: To investigate the efficacy and safety of antiviral treatment in patients with hepatitis C virus (HCV) infection and decompensated cirrhosis and determine the effects of virological response on long-term prognosis. METHODS: Sixty-six consecutive,interferon (IFN)-na(i)ve patients with HCV infection and decompensated cirrhosis were enrolled in this prospective study. All patients were given a 48-to 72-week course of IFN plus ribavirin (RBV) combined therapy,with a low accelerating dosage regimen using either:pegylated (PEG)-IFNa-2b at 1...
September 2015: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/26408730/stratified-survival-analysis-after-adjuvant-chemotherapy-of-colon-cancer-reveals-a-benefit-for-older-patients
#14
RANDOMIZED CONTROLLED TRIAL
Benjamin Mayer, Silvia Sander, Stephan Paschke, Doris Henne-Bruns, Karl-Heinrich Link, Marko Kornmann
AIM: Adjuvant treatment is still controversially discussed for elderly colon cancer (CC) patients. Our aim was to investigate the benefit of adjuvant treatment for younger (<70 years) and elderly (≥70 years) patients. PATIENTS AND METHODS: The long-term outcome of patients (n=855) enrolled in a randomized controlled trial comparing adjuvant chemotherapy with 5-FU alone, 5-FU plus folinic acid (FA), and 5-FU plus interferon-alpha (IFNa) was compared in younger (<70 years) and elderly (≥70 years) patients using a quotient of each patient's survival time and his expected residual life expectancy (QSL) and a multivariate Cox proportional hazards model...
October 2015: Anticancer Research
https://www.readbyqxmd.com/read/26299874/extended-duration-versus-standard-duration-of-peginterferon-alfa-2a-in-treatment-of-chronic-hepatitis-b-a-systematic-review-and-meta-analysis
#15
Zhengyan Wang, Ling Sun, Yuwan Wu, Qing Xia
In the last decade, PEG-IFNa-2a has been widely used in the treatment of chronic hepatitis B (CHB). The current standard duration is 48 weeks; however, several studies based on small sample sizes have indicated that treatment extended beyond 48 weeks improved clinical outcomes than standard 48 weeks of therapy. Therefore, we performed a meta-analysis to compare the efficacy and safety of extended duration versus standard duration treatment with PEG-IFNa-2a monotherapy for patients with CHB. Four studies comprising of 350 patients were included in our study...
April 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/26263557/infection-profiles-of-selected-aquabirnavirus-isolates-in-chse-cells
#16
Amr A A Gamil, Øystein Evensen, Stephen Mutoloki
The wide host range and antigenic diversity of aquabirnaviruses are reflected by the presence of a collection of isolates with different sero- and genotypic properties that have previously been classified as such. Differences in cytopathogenic mechanisms and host responses induced by these isolates have not been previously examined. In the present study, we investigated infection profiles induced by genetically and serologically closely related as well as distant isolates in-vitro. CHSE-214 cells were infected with either E1S (serotype A3, genogroup 3), VR-299 (serotype A1, genogroup 1), highly virulent Sp (TA) or avirulent Sp (PT) (serotype A2, genogroup 5)...
2015: PloS One
https://www.readbyqxmd.com/read/26222859/sustained-virologic-response-to-a-dual-peginterferon-alfa-2a-and-ribavirin-in-treating-chronic-hepatitis-c-infection-a-retrospective-cohort-study
#17
Cho Naing, Than Sitt, Aye Td Aung, Kyan Aung
In Myanmar, hepatitis C virus (HCV) infection prevalence is 2%. A combination therapy of pegylated interferon alfa-2a and ribavirin (PEG-IFNa/RBV) is a standard treatment, but the effect of this antiviral therapy needs evaluation as to determine the efficacy and safety of dual PEG-IFNa/RBV therapy in treating patients infected with HCV in Myanmar.This was a retrospective analysis of data from a single clinic exclusively for gastrointestinal diseases in Yangon, Myanmar. We assessed treatment responses at the defined time points and stratified by genotypes of HCV...
July 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26208754/ifna-of-black-carp-is-an-antiviral-cytokine-modified-with-n-linked-glycosylation
#18
Zhilin Huang, Song Chen, Jiachen Liu, Jun Xiao, Jun Yan, Hao Feng
Type I interferons (IFNs) play an important role in the antiviral immune response in teleost fish. In this study, one type I interferon (bcIFNa) of black carp (Mylopharyngodon piceus) has been cloned and characterized. The full-length cDNA of bcIFNa gene consists of 783 nucleotides and the predicted bcIFNa protein contains 185 amino acids. Semi-quantitative RT-PCR analysis demonstrated that bcIFNa mRNA transcription level in all the selected tissues of black carp was greatly increased at 33 h post spring viremia of carp virus (SVCV) infection...
October 2015: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26177342/the-value-of-repeat-thyroid-fine-needle-aspiration-biopsy-in-patients-with-a-previously-benign-result-how-often-does-it-alter-management
#19
Naykky Singh Ospina, Thomas J Sebo, John C Morris, M Regina Castro
BACKGROUND: Thyroid nodules are prevalent and mostly benign, being present in up to 67% of the population when assessed by ultrasound. Due to the variable diagnostic performance of ultrasound-guided fine-needle aspiration biopsy (USFNA) of the thyroid and the possibility of a false-negative result, current clinical guidelines recommend ultrasonographic follow-up of benign thyroid nodules. The objective of this study was to evaluate the clinical relevance of a repeat fine-needle aspiration (rFNA) in patients with an initial benign fine-needle aspiration biopsy (iFNA)...
October 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26113012/hcv-treatments-and-their-integration-into-rheumatology
#20
REVIEW
Dimitrios Vassilopoulos, Leonard H Calabrese
Hepatitis C virus (HCV) has been associated with distinct rheumatic syndromes including arthritis, sialadenitis, and cryoglobulinemic vasculitis (CV). The therapy of these HCV-associated syndromes includes antiviral therapy with or without the addition of immunosuppressives while clinical response is mainly seen in patients who clear the virus after antiviral therapy. Despite significant therapeutic advances, existing antiviral therapies with interferon-a (IFNa)-based schemes achieve viral eradication only in approximately half the patients...
August 2015: Current Rheumatology Reports
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