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https://www.readbyqxmd.com/read/29136875/a-turn-on-competitive-immunochromatographic-strips-integrated-with-quantum-dots-and-gold-nano-stars-for-cadmium-ion-detection
#1
Meng Xiao, Qiangqiang Fu, Haicong Shen, Yuan Chen, Wei Xiao, Daoguang Yan, Xiaojiang Tang, Zhiyong Zhong, Yong Tang
Immunochromatographic strips (ICSs) are inexpensive, simple, portable, and robust, and therefore have many uses in the medicinal, agricultural, and environmental industries. For detection of small molecules, current ICSs are competitive format (competitive ICSs, CICSs), which only offer a turn-off readout mode, and therefore lead to low sensitivity when evaluating results by the naked eye. To overcome this problem, we report a turn-on CICSs that relies on the ability of gold nano-stars (AuNSs) quenching the signal of quantum dots (QDs)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29127376/genuine-multipartite-entanglement-in-the-3-photon-decay-of-positronium
#2
Beatrix C Hiesmayr, Pawel Moskal
The electron-positron annihilation into two photons is a standard technology in medicine to observe e.g. metabolic processes in human bodies. A new tomograph will provide the possibility to observe not only direct e (+) e (-) annihilations but also the 3 photons from the decay of ortho-positronium atoms formed in the body. We show in this contribution that the three-photon state with respect to polarisation degrees of freedom depends on the angles between the photons and exhibits various specific entanglement features...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127318/minimally-invasive-hemostatic-materials-tackling-a-dilemma-of-fluidity-and-adhesion-by-photopolymerization-in-situ
#3
Yun Zhang, Dandan Song, Hong Huang, Zhiling Liang, Houhe Liu, Yugang Huang, Cheng Zhong, Guodong Ye
Hemostasis in vivo is a key to success in minimally invasive surgery (MIS). However, solid hemostatic materials cannot pass through the sheath tube of the MIS apparatus, while liquid ones are restricted by their low adhesion, which leads to them peeling off of tissue. To tackle the dilemma of fluidity and adhesion, a formulation containing a multifunctional sucrose allyl ether (SAE) monomer and an alpha-hydroxyketone liquid photoinitiator (HMPP) was applied as a lead hemostatic material for MIS. Real-time infrared results showed that SAE initiated by HMPP can rapidly polymerize into a transparent crosslinking membrane...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093641/spatiotemporal-analysis-of-tropical-disease-research-combining-europe-pmc-and-affiliation-mapping-web-services
#4
Magnus Palmblad, Vetle I Torvik
Background: Tropical medicine appeared as a distinct sub-discipline in the late nineteenth century, during a period of rapid European colonial expansion in Africa and Asia. After a dramatic drop after World War II, research on tropical diseases have received more attention and research funding in the twenty-first century. Methods: We used Apache Taverna to integrate Europe PMC and MapAffil web services, containing the spatiotemporal analysis workflow from a list of PubMed queries to a list of publication years and author affiliations geoparsed to latitudes and longitudes...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29072594/advances-in-fluorescent-single-chain-nanoparticles
#5
REVIEW
Julen De-La-Cuesta, Edurne González, José A Pomposo
Fluorophore molecules can be monitored by fluorescence spectroscopy and microscopy, which are highly useful and widely used techniques in cell biology, biochemistry, and medicine (e.g., biomarker analysis, immunoassays, cancer diagnosis). Several fluorescent micro- and nanoparticle systems based on block copolymer micelles and cross-linked polymer networks, quantum dots, π-conjugated polymers, and dendrimers have been evaluated as optical imaging systems. In this review, we highlight recent advances in the construction of fluorescent single-chain nanoparticles (SCNPs), which are valuable artificial soft nano-objects with a small tunable size (as small as 3 nm)...
October 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29058321/synthesis-and-structure-analysis-of-ferrocene-containing-pseudopeptides
#6
Gaetano Angelici, Marcin Górecki, Gennaro Pescitelli, Nicola Zanna, Magda Monari, Claudia Tomasini
Ferrocene with its aromaticity and facile redox properties is an attractive moiety to be incorporated into functional moieties. Medicinal applications of ferrocene are well known and ferrocene itself shows cytotoxic and antianemic properties. In this article, we will describe the synthesis and the structure analysis of two pseudopeptides containing a ferrocene moiety as N-terminal group. After purification, Fc-l-Phe-d-Oxd-OBn [l-Phel-phenylalanine; d-Oxd(4R,5S)-4-Methyl-5-carboxy-oxazolidin-2-one] appears as bright brown solid that spontaneously forms brown needles...
October 23, 2017: Biopolymers
https://www.readbyqxmd.com/read/29051461/exposure-to-inorganic-nanoparticles-routes-of-entry-immune-response-biodistribution-and-in-vitro-in-vivo-toxicity-evaluation
#7
REVIEW
Valeria De Matteis
The development of different kinds of nanoparticles, showing different physico-chemical properties, has fostered their large use in many fields, including medicine. As a consequence, inorganic nanoparticles (e.g., metals or semiconductors), have raised issues about their potential toxicity. The scientific community is investigating the toxicity mechanisms of these materials, in vitro and in vivo, in order to provide accurate references concerning their use. This review will give the readers a thorough exploration on the entry mechanisms of inorganic nanoparticles in the human body, such as titanium dioxide nanoparticles (TiO₂NPs), silicon dioxide nanoparticles (SiO₂NPs), zinc oxide nanoparticles (ZnONPs), silver nanoparticles (AgNPs), gold nanoparticles (AuNPs) and quantum dots (QDsNPs)...
October 17, 2017: Toxics
https://www.readbyqxmd.com/read/29040931/a-combined-experimental-ir-raman-and-uv-vis-and-quantum-chemical-study-of-canadine
#8
Bhawani Datt Joshi, Anubha Srivastava, Poonam Tandon, Sudha Jain, A P Ayala
Plant based natural products cover a major sector of the medicinal field, as such focus on plant research has been increased all over the world. As an attempt to aid that research, we have performed structural and spectroscopic analysis of a natural product, an alkaloid: canadine. Both ab initio Hartree-Fock (HF) and density functional theory (DFT) employing B3LYP using 6-311++G(d,p) basis set were used for the calculations. The calculated vibrational frequencies were scaled and compared with the experimental infrared and Raman spectra...
October 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28961225/graphene-quantum-dots-electrochemistry-and-sensitive-electrocatalytic-glucose-sensor-development
#9
Sanju Gupta, Tyler Smith, Alexander Banaszak, John Boeckl
Graphene quantum dots (GQDs), derived from functionalized graphene precursors are graphene sheets a few nanometers in the lateral dimension having a several-layer thickness. They are zero-dimensional materials with quantum confinement and edge site effects. Intense research interest in GQDs is attributed to their unique physicochemical phenomena arising from the sp²-bonded carbon nanocore surrounded with edged plane functional moieties. In this work, GQDs are synthesized by both solvothermal and hydrothermal techniques, with the optimal size of 5 nm determined using high-resolution transmission electron microscopy, with additional UV-Vis absorption and fluorescence spectroscopy, revealing electronic band signatures in the blue-violet region...
September 29, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28957627/automated-transition-state-search-and-its-application-to-diverse-types-of-organic-reactions
#10
Leif D Jacobson, Art D Bochevarov, Mark A Watson, Thomas F Hughes, David Rinaldo, Stephan Ehrlich, Thomas B Steinbrecher, S Vaitheeswaran, Dean M Philipp, Mathew D Halls, Richard A Friesner
Transition state search is at the center of multiple types of computational chemical predictions related to mechanistic investigations, reactivity and regioselectivity predictions, and catalyst design. The process of finding transition states in practice is, however, a laborious multistep operation that requires significant user involvement. Here, we report a highly automated workflow designed to locate transition states for a given elementary reaction with minimal setup overhead. The only essential inputs required from the user are the structures of the separated reactants and products...
October 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28955356/phosphorous-application-improves-drought-tolerance-of-phoebe-zhennan
#11
Akash Tariq, Kaiwen Pan, Olusanya A Olatunji, Corina Graciano, Zilong Li, Feng Sun, Xiaoming Sun, Dagang Song, Wenkai Chen, Aiping Zhang, Xiaogang Wu, Lin Zhang, Deng Mingrui, Qinli Xiong, Chenggang Liu
Phoebe zhennan (Gold Phoebe) is a threatened tree species in China and a valuable and important source of wood and bioactive compounds used in medicine. Apart from anthropogenic disturbances, several biotic constraints currently restrict its growth and development. However, little attention has been given to building adaptive strategies for its conservation by examining its morphological and physio-biochemical responses to drought stress, and the role of fertilizers on these responses. A randomized experimental design was used to investigate the effects of two levels of irrigation (well-watered and drought-stressed) and phosphorous (P) fertilization treatment (with and without P) to assess the morphological and physio-biochemical responses of P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28925715/novel-carbon-dots-derived-from-schizonepetae-herba-carbonisata-and-investigation-of-their-haemostatic-efficacy
#12
Meiling Zhang, Yan Zhao, Jinjun Cheng, Xiaoman Liu, Yongzhi Wang, Xin Yan, Yue Zhang, Fang Lu, Qingguo Wang, Huihua Qu
Schizonepetae Herba Carbonisata (SHC) has been used in traditional Chinese medicine (TCM) to treat haemorrhagic diseases for more than 1000 years. However, little information is available on its haemostatic components and mechanism. In this study, we developed novel water-soluble carbon dots (CDs) in aqueous extracts of SHC for the first time and a modified pyrolysis method was used to prepare the SHC using Schizonepetae Herba (SH) as the sole precursor. The SHC-CDs were characterized using transmission electron microscopy (TEM), high-resolution TEM (HRTEM), Fourier transform infrared (FT-IR), ultraviolet-visible (UV-Vis) and fluorescence spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and high-performance liquid chromatography (HPLC)...
September 19, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28919707/quantum-mechanics-implementation-in-drug-design-workflows-does-it-really-help
#13
REVIEW
Olayide A Arodola, Mahmoud Es Soliman
The pharmaceutical industry is progressively operating in an era where development costs are constantly under pressure, higher percentages of drugs are demanded, and the drug-discovery process is a trial-and-error run. The profit that flows in with the discovery of new drugs has always been the motivation for the industry to keep up the pace and keep abreast with the endless demand for medicines. The process of finding a molecule that binds to the target protein using in silico tools has made computational chemistry a valuable tool in drug discovery in both academic research and pharmaceutical industry...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28898510/multi-photon-absorption-in-metal-organic-frameworks
#14
Raghavender Medishetty, Lydia Nemec, Venkatram Nalla, Sebastian Henke, Marek Samoć, Karsten Reuter, Roland A Fischer
Multi-photon absorption (MPA) is among the most prominent nonlinear optical (NLO) effects and has applications, for example in telecommunications, defense, photonics, and bio-medicines. Established MPA materials include dyes, quantum dots, organometallics and conjugated polymers, most often dispersed in solution. We demonstrate how metal-organic frameworks (MOFs), a novel NLO solid-state materials class, can be designed for exceptionally strong MPA behavior. MOFs consisting of zirconium- and hafnium-oxo-clusters and featuring a chromophore linker based on the tetraphenylethene (TPE) molecule exhibit record high two-photon absorption (2PA) cross-section values, up to 3600 GM...
September 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28875970/-evaluation-of-selected-vascular-active-factors-in-patients-after-myocardial-infarction-subjected-to-cardiac-rehabilitation
#15
Joanna Kapusta, Anna Mejer-Barczewska, Edward Kowalczyk, Robert Irzmański, Jan Kowalski
Atherosclerosis is an inflammatory process that develops in the coronary arteries. Clinically active agents such as proinflammatory interleukins, TNF-α, tissue inhibitors of metalloproteinases (including TIMP-1), and vascular endothelial growth factor (VEGF), are important factors in the development of acute coronary syndromes. AIM: The aim of the study was to evaluate the effect of cardiac rehabilitation (stage II) on the concentration of selected vascular active factors (IL- 1, IL-6, TIMP-1, VEGF)...
August 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28870210/hemostatic-bioactivity-of-novel-pollen-typhae-carbonisata-derived-carbon-quantum-dots
#16
Xin Yan, Yan Zhao, Juan Luo, Wei Xiong, Xiaoman Liu, Jinjun Cheng, Yongzhi Wang, Meiling Zhang, Huihua Qu
BACKGROUND: Pollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) and high-resolution TEM, as well as Fourier transform infrared, ultraviolet-visible, and fluorescence spectroscopy...
September 5, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28862621/flyscan-opportunities-in-medicine-the-case-of-quantum-rattle-based-on-gold-quantum-dots
#17
Emmanuel Esteve, Solenn Reguer, Cédric Boissiere, Corinne Chanéac, Gustavo Lugo, Chantal Jouanneau, Cristian Mocuta, Dominique Thiaudière, Nicolas Leclercq, Bernard Leyh, Jean François Greisch, Julien Berthault, Michel Daudon, Pierre Ronco, Dominique Bazin
The new rapid scan method, Flyscan mode, implemented on the DiffAbs beamline at Synchrotron SOLEIL, allows fast micro-X-ray fluorescence data acquisition. It paves the way for applications in the biomedical field where a large amount of data is needed to generate meaningful information for the clinician. This study presents a complete set of data acquired after injection of gold-cluster-enriched mesoporous silica nanospheres, used as potential theranostic vectors, into rats. While classical X-ray fluorescence investigations (using step-by-step acquisitions) are based on a limited number of samples (approximately one per day at the DiffAbs beamline), the Flyscan mode has enabled gathering information on the interaction of nanometer-scale vectors in different organs such as liver, spleen and kidney at the micrometer scale, for five rats, in only a single five-day synchrotron shift...
September 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28852273/clinical-practice-in-community-medicine-challenges-and-opportunities
#18
Rajesh Kumar
Clinical practice with community health perspective makes community medicine a unique specialty. In their health centers, community physicians not only implement disease prevention programs, assess community health needs, manage healthcare teams and advocate for health promoting policies but also diagnose and treat diseases. However, participation of community medicine faculty in the delivery of clinical care varies from place to place due to administrative constraints. Health centers attached with medical college are not dependent on community medicine faculty for clinical service as these centers have their own medical and paramedical staff; whereas, other clinical departments in medical colleges depend on their faculty for delivery of clinical care in the hospital...
July 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28842617/simultaneous-gene-delivery-and-tracking-through-preparation-of-photo-luminescent-nanoparticles-based-on-graphene-quantum-dots-and-chimeric-peptides
#19
Soroush Moasses Ghafary, Maryam Nikkhah, Shadie Hatamie, Saman Hosseinkhani
Designing suitable nano-carriers for simultaneous gene delivery and tracking is in the research priorities of the molecular medicine. Non-toxic graphene quantum dots (GQDs) with two different (green and red) emission colors are synthesized by Hummer's method and characterized by UV-Vis, Photoluminescence (PL), Fourier Transform Infrared (FTIR) and Raman spectroscopies, Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The GQDs are conjugated with MPG-2H1 chimeric peptide and plasmid DNA (pDNA) by non-covalent interactions...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28841747/-psychotherapy-quo-vadis
#20
Gunther Meinlschmidt, Marion Tegethoff
Background: The science and practice of psychotherapy is continuously developing. The goal of this article is to describe new impulses, guiding current advancements in the field. Methods: This paper provides a selective narrative review, synthesizing and condensing relevant literature identified through various sources, including MEDLINE, EMBASE, PsycINFO, and "Web of Science", as well as citation tracking, to elaborate key developments in the field of psychotherapy Results: We describe several dynamics: 1) Following up the so-called "third wave of cognitive behavioral therapy", new interventions arise that have at their core fostering interpersonal virtues, such as compassion, forgiveness, and gratitude; 2) Based on technological quantum leaps, new interventions arise that exploit current developments in the field of new media, information, and communication technologies, as well as brain imaging, such as digital interventions for mental disorders and new forms of neurofeedback; 3) Inspired by the field of positive psychology, there is a revival of the promotion of strength and resilience in therapeutic contexts; 4) In light of the new paradigm "precision medicine", the issue of differential and adaptive indication of psychotherapy, addressed with new methods, regains relevance and drives a new field of "precision psychotherapy"...
August 2017: Fortschritte der Neurologie-Psychiatrie
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