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Quantum Medicine

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https://www.readbyqxmd.com/read/28633990/cellular-gauge-symmetry-and-the-li-organization-principle-a-mathematical-addendum-quantifying-energetic-dynamics-in-physical-and-biological-systems-through-a-simple-geometric-tool-and-geodetic-curves
#1
REVIEW
Alexander Yurkin, Arturo Tozzi, James F Peters, Pedro C Marijuán
The present Addendum complements the accompanying paper "Cellular Gauge Symmetry and the Li Organization Principle"; it illustrates a recently-developed geometrical physical model able to assess electronic movements and energetic paths in atomic shells. The model describes a multi-level system of circular, wavy and zigzag paths which can be projected onto a horizontal tape. This model ushers in a visual interpretation of the distribution of atomic electrons' energy levels and the corresponding quantum numbers through rather simple tools, such as compasses, rulers and straightforward calculations...
June 17, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28608445/tailoring-the-volatility-and-stability-of-oligopeptides
#2
J Schätti, U Sezer, S Pedalino, J P Cotter, M Arndt, M Mayor, V Köhler
Amino acids are essential building blocks of life and fluorinated derivatives have gained interest in chemistry and medicine. Modern mass spectrometry has enabled the study of oligo- and polypeptides as isolated entities in the gas phase, but predominantly as singly or even multiply charged species. While laser desorption of neutral peptides into adiabatically expanding supersonic noble gas jets is possible, UV-VIS spectroscopy, electric or magnetic deflectometry as well as quantum interferometry would profit from the possibility to prepare thermally slow molecular beams...
June 12, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28585624/exploiting-the-biomimetic-and-luminescence-properties-of-multivalent-dendrimer-semiconductor-nanohybrid-materials-in-the-ultra-low-level-determination-of-folic-acid
#3
Somashree Kundu, Susmita Maiti, Tushar Kanti Das, Debasmita Ghosh, Chandra Nath Roy, Abhijit Saha
In view of the enhanced generation of folate receptors in cancerous cells and diseases linked to the deficiency of folic acid, such as anemia, mental devolution, congenital malformation, etc., the development of a simple method for the ultra-sensitive determination of folic acid remains a long-standing issue for practical applications in medicine and biotechnology. Thus, the proposed luminescence based strategy involving multifunctional poly(amidoamine) (PAMAM) dendrimer encapsulated quantum dots (QDs) as a probe provides a simple, fast and efficient method for the selective determination of folic acid at the nano-molar level...
June 6, 2017: Analyst
https://www.readbyqxmd.com/read/28578662/possible-contribution-of-quantum-like-correlations-to-the-placebo-effect-consequences-on-blind-trials
#4
Francis Beauvais
BACKGROUND: Factors that participate in the biological changes associated with a placebo are not completely understood. Natural evolution, mean regression, concomitant procedures and other non specific effects are well-known factors that contribute to the "placebo effect". In this article, we suggest that quantum-like correlations predicted by a probabilistic modeling could also play a role. RESULTS: An elementary experiment in biology or medicine comparing the biological changes associated with two placebos is modeled...
June 2, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28572453/nanoscale-nuclear-magnetic-resonance-with-chemical-resolution
#5
Nabeel Aslam, Matthias Pfender, Philipp Neumann, Rolf Reuter, Andrea Zappe, Felipe Fávaro de Oliveira, Andrej Denisenko, Hitoshi Sumiya, Shinobu Onoda, Junichi Isoya, Jörg Wrachtrup
Nuclear magnetic resonance (NMR) spectroscopy is a key analytical technique in chemistry, biology and medicine. However, conventional NMR spectroscopy requires at least nanoliter sized sample volume to achieve sufficient signal. Here we combine the use of a quantum memory and high magnetic fields with a dedicated quantum sensor based on nitrogen vacancy centers in diamond to achieve chemical shift resolution in (1)H and (19)F NMR spectroscopy of 20 zeptoliter sample volumes. We demonstrate the application of NMR pulse sequences to achieve homonuclear decoupling and spin diffusion measurements...
June 1, 2017: Science
https://www.readbyqxmd.com/read/28552788/solasodine-3-o-%C3%AE-d-glucopyranoside-kills-candida-albicans-by-disrupting-the-intracellular-vacuole
#6
Wenqiang Chang, Ying Li, Ming Zhang, Sha Zheng, Yan Li, Hongxiang Lou
The increasing incidence of fungal infections and emergence of drug resistance underlie the constant search for new antifungal agents and exploration of their modes of action. The present study aimed to investigate the antifungal mechanisms of solasodine-3-O-β-d-glucopyranoside (SG) isolated from the medicinal plant Solanum nigrum L. In vitro, SG displayed potent fungicidal activity against both azole-sensitive and azole-resistant Candida albicans strains in Spider medium with its MICs of 32 μg/ml. Analysis of structure and bioactivity revealed that both the glucosyl residue and NH group were required for SG activity...
May 25, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28539053/atomic-psychiatry-an-essay
#7
Ian Patrick Paddy Burges Watson
OBJECTIVE: This article aims to address the need to rethink the classification of mental illness and to draw attention to the current use of quantum biology and its likely future use in understanding the nature of mental illness. CONCLUSION: It is desirable to separate out neuroscience and clinical research and to become better acquainted with the concepts of quantum mechanical/quantum biological theory and its contribution to medicine.
May 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28538206/spectroscopic-far-or-terahertz-mid-infrared-and-raman-investigation-thermal-analysis-and-biological-activity-of-piplartine
#8
Anubha Srivastava, T Karthick, B D Joshi, Rashmi Mishra, Poonam Tandon, A P Ayala, Javier Ellena
Research in the field of medicinal plants including Piper species like long pepper (Piper longum L.- Piperaceae) is increasing all over the world due to its use in traditional and Ayurvedic medicine. Piplartine (piperlongumine, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone), a biologically active alkaloid/amide was isolated from the phytochemical investigations of Piper species, as long pepper. This alkaloid has cytotoxic, anti-fungal, anti-diabetic, anti-platelet aggregation, anti-tumoral, anxiolytic, anti-depressant, anti-leishmanial, and genotoxic activities, but, its anticancer property is the most promising and has been widely explored...
May 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28509422/evaluation-of-the-medicinal-potential-of-two-ruthenium-ii-polypyridine-complexes-as-one-and-two-photon-photodynamic-therapy-photosensitizers
#9
Jeannine Hess, Huaiyi Huang, Adrian Kaiser, Vanessa Pierroz, Olivier Blacque, Hui Chao, Gilles Gasser
Two [Ru(phen)2dppz]2+ derivatives (phen = 1,10-phenantroline, dppz = dipyrido[3,2-a:2',3'-c]phenazine) with different functional groups on the dppz ligand [dppz-7,8-(OMe)2 (1), dppz-7,8-(OH)2 (2)] have been synthesized, characterized and investigated as photosensitizers (PSs) for photodynamic therapy (PDT) against cancer. Both complexes showed intense red phosphorescence and promising singlet oxygen (1O2) quantum yields of 75 % (1) and 54 % (2), respectively, in acetonitrile. 1 (logPo/w = -0.52, 2.4 nmol Ru per mg protein) was found to be more lipophilic, having also a higher cellular uptake efficiency compared to 2 (logPo/w = -0...
May 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28506901/new-isoflavonoids-from-the-extract-of-rhynchosia-precatoria-humb-bonpl-ex-willd-dc-and-their-antimycobacterial-activity
#10
Enrique Wenceslao Coronado-Aceves, Giulia Gigliarelli, Adriana Garibay-Escobar, Ramón Enrique Robles Zepeda, Massimo Curini, Jaime López Cervantes, Clara Inés Inés Espitia-Pinzón, Stefano Superchi, Stefania Vergura, Maria Carla Marcotullio
ETHNOPHARMACOLOGY RELEVANCE: The evaluation of the antimycobacterial activity of extracts of medicinal plants used by Mayos against tuberculosis and respiratory problems, allowed the identification of Rhynchosia precatoria (Humb. & Bonpl. ex Willd.) DC (Fabaceae) as the best candidate to find new antimycobacterial compounds. AIM OF THE STUDY: To isolate and characterize the compounds of R. precatoria responsible for the inhibitory and bactericidal activity against Mycobacterium tuberculosis H37Rv and Mycobacterium smegmatis ATCC 700084...
May 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28463765/bright-carbon-dots-as-fluorescence-sensing-agents-for-bacteria-and-curcumin
#11
Mirza Muhammad Fahad Baig, Yu-Chie Chen
Carbon dots (C-dots) are fluorescent nanomaterials that possess good photostability and low toxicity. They have been used as sensing probes and bioimaging agents for a variety of biological species. Numerous methods are available to generate C-dots. Nevertheless, simple and straightforward synthesis methods must be explored for the synthesis of C-dots from inexpensive, natural sources. In this study, we developed a simple method to generate C-dots from inexpensive chicken egg whites through a one-step heating reaction...
April 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28462124/the-quantum-universe-philosophical-foundations-and-oriental-medicine
#12
REVIEW
Menas C Kafatos, Keun-Hang Yang
The existence of universal principles in both science and medicine implies that one can explore their common applicability. Here we explore what we have learned from quantum mechanics, phenomena such as entanglement and nonlocality, the role of participation of the observer, and how these may apply to oriental medicine. The universal principles of integrated polarity, recursion, and creative interactivity apply to all levels of existence and all human activities, including healing and medicine. This review examines the possibility that what we have learned from quantum mechanics may provide clues to better understand the operational principles of oriental medicine in an integrated way...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28453021/binary-twinned-icosahedral-b21h18-interacts-with-cyclodextrins-as-a-precedent-for-its-complexation-with-other-organic-motifs
#13
Saltuk M Eyrilmez, Eduard Bernhardt, Juan Z Dávalos, Martin Lepšík, Pavel Hobza, Khaleel I Assaf, Werner M Nau, Josef Holub, Josep M Oliva-Enrich, Jindřich Fanfrlík, Drahomír Hnyk
The weakly coordinating binary macropolyhedral anion closo,closo-[B21H18](-) (B21; D3h symmetry) has been synthesized using a simplified strategy compared to that in the literature. While gas-phase complexes of B21 with β- and γ-cyclodextrin (CD) were detected using ESI FT-ICR spectrometric measurements, α-CD did not bind to the B21 guest. This spectroscopic evidence has been interpreted using quantum-chemical computations, showing that β- and γ-CD are able to interact with B21 due to their larger cavities, in contrast to the smaller α-CD...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28382642/effects-of-concentration-and-vendor-specific-composition-of-formalin-on-postmortem-mri-of-the-human-brain
#14
Christoph Birkl, Martin Soellradl, Anna Maria Toeglhofer, Stefanie Krassnig, Marlene Leoni, Lukas Pirpamer, Thomas Vorauer, Heinz Krenn, Johannes Haybaeck, Franz Fazekas, Stefan Ropele, Christian Langkammer
PURPOSE: Formalin fixation prevents tissue autolysis by crosslinking proteins and changes tissue microstructure and MRI signal characteristics. Previous studies showed high variations in MR relaxation time constants of formalin fixed brain tissue, which has been attributed to the use of different formalin concentrations. Our investigations confirmed the influence of formalin concentration on relaxation times and unexpectedly revealed an influence of vendor specific formalin composition, which has not been investigated so far...
April 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28377182/a-biophysical-approach-to-cancer-dynamics-quantum-chaos-and-energy-turbulence
#15
REVIEW
Abicumaran Uthamacumaran
Cancer is a term used to define a collective set of rapidly evolving cells with immortalized replication, altered epimetabolomes and patterns of longevity. Identifying a common signaling cascade to target all cancers has been a major obstacle in medicine. A quantum dynamic framework has been established to explain mutation theory, biological energy landscapes, cell communication patterns and the cancer interactome under the influence of quantum chaos. Quantum tunneling in mutagenesis, vacuum energy field dynamics, and cytoskeletal networks in tumor morphogenesis have revealed the applicability for description of cancer dynamics, which is discussed with a brief account of endogenous hallucinogens, bioelectromagnetism and water fluctuations...
April 2, 2017: Bio Systems
https://www.readbyqxmd.com/read/28368062/graphene-quantum-dot-based-switch-on-nanosensors-for-intracellular-cytokine-monitoring
#16
Guozhen Liu, Kai Zhang, Ke Ma, Andrew Care, Mark R Hutchinson, Ewa M Goldys
The detection of cytokines in body fluids, cells, tissues and organisms continues to attract considerable attention due to the importance of these key cell signalling molecules in biology and medicine. We report a graphene quantum dot (GQD) based aptasensor able to specifically detect ultra-small amounts of cytokine molecules intracellularly. Graphene quantum dots modified with cytokine aptamers (Ap-GQDs) and epitope modified GQDs (Ep-GQDs) were prepared; both are normally fluorescent at sufficient dilution...
April 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28360819/surface-initiated-ring-opening-metathesis-polymerization-si-romp-to-attach-a-tethered-organic-corona-onto-cdse-zns-core-shell-quantum-dots
#17
Fatma Vatansever, Michael R Hamblin
Core-shell CdSe/ZnS quantum dots (QDs) are useful as tunable photostable fluorophores for multiple applications in industry, biology, and medicine. However, to achieve the optimum optical properties, the surface of the QDs must be passivated to remove charged sites that might bind extraneous substances and allow aggregation. Here we describe a method of growing an organic polymer corona onto the QD surface using the bottom-up approach of surface-initiated ring-opening metathesis polymerization (SI-ROMP) with Grubbs catalyst...
October 2016: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28338625/-r-aloesaponol-iii-8-methyl-ether-from-eremurus-persicus-a-novel-compound-against-leishmaniosis
#18
Daniela Rossi, Karzan Mahmood Ahmed, Raffaella Gaggeri, Serena Della Volpe, Lauretta Maggi, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate, Federica Corana, Emanuela Martino, Marisa Machado, Raquel Varandas, Maria do Céu Sousa, Simona Collina
Leishmaniosis is a neglected tropical disease which affects several millions of people worldwide. The current drug therapies are expensive and often lack efficacy, mainly due to the development of parasite resistance. Hence, there is an urgent need for new drugs effective against Leishmania infections. As a part of our ongoing study on the phytochemical characterization and biological investigation of plants used in the traditional medicine of western and central Asia, in the present study, we focused on Eremurus persicus root extract in order to evaluate its potential in the treatment of leishmaniosis...
March 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28325225/-unconventional-experiments-in-biology-and-medicine-with-optimized-design-based-on-quantum-like-correlations
#19
Francis Beauvais
In previous articles, a description of 'unconventional' experiments (e.g. in vitro or clinical studies based on high dilutions, 'memory of water' or homeopathy) using quantum-like probability was proposed. Because the mathematical formulations of quantum logic are frequently an obstacle for physicians and biologists, a modified modeling that rests on classical probability is described in the present article. This modeling is inspired from a relational interpretation of quantum physics that applies not only to microscopic objects, but also to macroscopic structures, including experimental devices and observers...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28299798/sterol-glycosyltransferases-required-for-adaptation-of-withania-somnifera-at-high-temperature
#20
Gaurav Singh, Manish Tiwari, Surendra P Singh, Ruchi Singh, Surendra Singh, Pramod A Shirke, Prabodh K Trivedi, Pratibha Misra
Heat is a major environmental stress factor that confines growth, productivity, and metabolism of plants. Plants respond to such unfavorable conditions through changes in their physiological, biochemical and developmental processes. Withania somnifera, an important medicinal plant, grows in hot and dry conditions, however, molecular mechanisms related to such adaptive properties are not known. Here, we elucidated that members of the sterol glycosyltransferases (SGT) gene family play important roles in the survival of W...
March 16, 2017: Physiologia Plantarum
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