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https://www.readbyqxmd.com/read/29925574/improving-guideline-based-streptococcal-pharyngitis-testing-a-quality-improvement-initiative
#1
Laura E Norton, Brian R Lee, Lory Harte, Keith Mann, Jason G Newland, R Alan Grimes, Angela L Myers
BACKGROUND AND OBJECTIVES: Acute pharyngitis is a common diagnosis in ambulatory pediatrics. The Infectious Diseases Society of America (IDSA) clinical practice guideline for group A streptococcal (GAS) pharyngitis recommends strict criteria for GAS testing to avoid misdiagnosis and unnecessary treatment of children who are colonized with group A Streptococcus . We sought to improve adherence to the IDSA guideline for testing and treatment of GAS pharyngitis in a large community pediatrics practice...
June 20, 2018: Pediatrics
https://www.readbyqxmd.com/read/29897938/epidemiology-of-nontuberculous-mycobacterial-infections-in-the-u-s-veterans-health-administration
#2
Makoto M Jones, Kevin L Winthrop, Scott D Nelson, Scott L Duvall, Olga V Patterson, Kevin E Nechodom, Kimberly E Findley, Lewis J Radonovich, Matthew H Samore, Kevin P Fennelly
OBJECTIVE: We identified patients with non-tuberculous mycobacterial (NTM) disease in the US Veterans Health Administration (VHA), examined the distribution of diseases by NTM species, and explored the association between NTM disease and the frequency of clinic visits and mortality. METHODS: We combined mycobacterial isolate (from natural language processing) with ICD-9-CM diagnoses from VHA data between 2008 and 2012 and then applied modified ATS/IDSA guidelines for NTM diagnosis...
2018: PloS One
https://www.readbyqxmd.com/read/29861799/sequential-measurements-of-pentraxin-3-serum-levels-in-patients-with-ventilator-associated-pneumonia-a-nested-case-control-study
#3
Huseyin Bilgin, Murat Haliloglu, Ali Yaman, Pinar Ay, Beliz Bilgili, Mustafa Kemal Arslantas, Filiz Ture Ozdemir, Goncagul Haklar, Ismail Cinel, Lutfiye Mulazimoglu
Purpose: The main purpose of this study was to investigate the dynamics of pentraxin 3 (PTX3) compared with procalcitonin (PCT) and C-reactive protein (CRP) in patients with suspicion of ventilator-associated pneumonia (VAP). Materials and Methods: We designed a nested case-control study. This study was performed in the Surgical Intensive Care Unit of a tertiary care academic university and teaching hospital. Ninety-one adults who were mechanically ventilated for >48 hours were enrolled in the study...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29858008/clinical-radiological-and-molecular-features-of-mycobacterium-kansasii-pulmonary-disease
#4
Zofia Bakuła, Justyna Kościuch, Aleksandra Safianowska, Małgorzata Proboszcz, Jacek Bielecki, Jakko van Ingen, Rafał Krenke, Tomasz Jagielski
BACKGROUND: Studies concerning sociodemographic, clinical, and laboratory features of Mycobacterium kansasii pulmonary disease are few and based on small patient cohorts. The objective of the study was to evaluate characteristics of patients from whom M. kansasii respiratory isolates were recovered and to provide a detailed description of M. kansasii disease. BASIC PROCEDURES: Retrospective review of electronic medical records of all patients for whom at least one positive M...
June 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29850828/factors-associated-with-pneumonia-severity-in-children-a-systematic-review
#5
Preston Dean, Todd A Florin
Community-acquired pneumonia in children is associated with significant morbidity and mortality; however, data are limited in predicting which children will have negative outcomes, including clinical deterioration, severe disease, or development of complications. The Pediatric Infectious Diseases Society/Infectious Diseases Society of America (PIDS/IDSA) pediatric pneumonia guideline includes criteria that were modified from adult criteria and define pneumonia severity to assist with resource allocation and site-of-care decision-making...
May 30, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29850195/the-kinetics-of-anti-hla-antibodies-in-the-first-year-after-kidney-transplantation-in-whom-and-when-should-they-be-monitored
#6
Maria Cristina Ribeiro de Castro, Erick A Barbosa, Renata P Souza, Fabiana Agena, Patrícia S de Souza, Gabriella Maciel, Hélcio Rodrigues, Nicolas Panajotopoulos, Daísa S David, Flávio J de Paula, Elias David-Neto
The impact of the kinetics of the anti-HLA antibodies after KTx on the occurrence of acute rejection as well as the better time-point to monitor anti-HLA Abs after transplantation is not completely defined. This prospective study followed 150 patients over 12 months after transplantation. Serum IgG anti-HLA Abs were detected by single antigen beads after typing donors and recipients for loci A, B, C, DR, and DQ. Before KTx, 89 patients did not present anti-HLA Abs and 2% developed "de novo" Abs during the 1st year, 39 patients were sensitized without DSAs, and 13% developed DSA after surgery; all of them presented ABMR...
2018: Journal of Transplantation
https://www.readbyqxmd.com/read/29807377/-new-guidelines-and-data-to-clostridium-difficile-what-s-new
#7
Christoph Lübbert, Norman Lippmann, Amrei von Braun
The incidence of Clostridium difficile infections (CDI) remains on a high level globally. In Germany, the burden of disease and especially the number of severe or even lethal cases continue to increase. The main risk factor for the development of CDI is the exposure to broad-spectrum antibiotics, which disturb the intestinal microbiota and therefore enable the colonization with C. difficile. According to IDSA's and SHEA's updated US guidelines, vancomycin is the treatment of choice. Fidaxomicin is as effective as vancomycin, but its advantage is the lower rate of recurrence...
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29773899/management-of-acute-hcv-infection-in-the-era-of-direct-acting-antiviral-therapy
#8
REVIEW
Marianne Martinello, Behzad Hajarizadeh, Jason Grebely, Gregory J Dore, Gail V Matthews
The management of acute HCV infection has not been standardized following the availability of direct-acting antiviral agents (DAAs) for chronic HCV infection, and substantial uncertainty exists regarding the optimal treatment regimen and duration. Despite the lack of direct evidence, the 2016 American Association for the Study of Liver Diseases (AASLD)-Infectious Diseases Society of America (IDSA) guidelines supported "the same regimens for acute HCV as recommended for chronic HCV infection … owing to high efficacy and safety", whereas the 2016 European Association for the Study of the Liver (EASL) guidelines recommended sofosbuvir-ledipasvir, sofosbuvir-velpatasvir or sofosbuvir plus daclatasvir for 8 weeks in acute HCV infection, with a longer duration of 12 weeks recommended for those infected with HIV and/or baseline HCV RNA levels >1,000,000 IU/ml...
May 17, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29771360/patient-and-treatment-characteristics-by-infecting-organism-in-cerebrospinal-fluid-shunt-infection
#9
Tamara D Simon, Matthew P Kronman, Kathryn B Whitlock, Samuel R Browd, Richard Holubkov, John R W Kestle, Abhaya V Kulkarni, Marcie Langley, David D Limbrick, Thomas G Luerssen, Jerry Oakes, Jay Riva-Cambrin, Curtis Rozzelle, Chevis N Shannon, Mandeep Tamber, John C Wellons Iii, William E Whitehead, Nicole Mayer-Hamblett
Background: Previous studies of cerebrospinal fluid (CSF) shunt infection treatment have been limited in size and unable to compare patient and treatment characteristics by infecting organism. Our objective was to describe variation in patient and treatment characteristics for children with first CSF shunt infection, stratified by infecting organism subgroups outlined in the 2017 Infectious Disease Society of America's (IDSA) guidelines. Methods: We studied a prospective cohort of children <18 years of age undergoing treatment for first CSF shunt infection at one of 7 Hydrocephalus Clinical Research Network hospitals from April 2008 to December 2012...
May 15, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29763277/infectious-diarrhea-idsa-updates-guidelines-for-diagnosis-and-management
#10
Amber Randel
No abstract text is available yet for this article.
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29761071/long-term-conventionally-dosed-vancomycin-therapy-in-patients-with-orthopaedic-implant-related-infections-seems-as-effective-and-safe-as-long-term-penicillin-or-clindamycin-therapy-a-retrospective-cohort-study-of-103-patients
#11
Jacomien Aleman, Dirk Jan F Moojen, Marc L van Ogtrop, Rudolf W Poolman, Eric J F Franssen
Objectives : Antimicrobial therapy is one of the cornerstones of orthopaedic implant-related infections (OIRI) treatment. Infections with Gram-positive bacteria are often treated with vancomycin, penicillin or clindamycin. A recent IDSA guideline suggests increasing the dose of vancomycin to increase the trough vancomycin target serum concentrations. This is deemed necessary because of an observed decrease in vancomycin susceptibility among Gram-positive bacteria. However, elevated vancomycin concentrations are correlated with the risk of nephrotoxicity, especially with prolonged therapy...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29747285/-expert-consensus-on-the-diagnosis-and-treatment-of-cryptococcal-meningitis
#12
Z Y Liu, G Q Wang, L P Zhu, X J Lyu, Q Q Zhang, Y S Yu, Z H Zhou, Y B Liu, W P Cai, R Y Li, W H Zhang, F J Zhang, H Wu, Y C Xu, H Z Lu, T S Li
Cryptococcal meningitis is a common and refractory central nervous system infection, with high rates of mortality and disability. The experts of the Society of Infectious Diseases of Chinese Medical Association have reached this consensus after a thorough discussion. Based on the current situation of cryptococcal meningitis in China, the management of cryptococcal meningitis includes 6 aspects: introduction, microorganism identification, clinical manifestations and diagnosis, principles of antifungal therapy, treatment of refractory and recurrent meningitis, treatment of intracranial hypertension...
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29744261/antimicrobial-stewardship-without-infectious-disease-physician-for-patients-with-candidemia-a-before-and-after-study
#13
Minoru Murakami, Hirokazu Komatsu, Masahide Sugiyama, Yuhei Ichikawa, Kyoko Ide, Rumi Tsuchiya, Kenji Kunieda, Akiko Magishi, Gaku Akiyama, Fumihide Miura, Kunihiko Okada, Masaya Ikezoe
Background: Little is known about the effects of antimicrobial stewardship team (AST) without infectious disease physician (IDP) on clinical outcome in patients with candidemia. Methods: We conducted a before and after study involving patients with hospital-acquired candidemia at a tertiary hospital without IDPs. The AST consisted of physicians, pharmacists, nurse, microbiologist, and administrative staff. A candidemia care bundle was developed based on the Infectious Disease Society of America (IDSA) guideline...
May 2018: Journal of General and Family Medicine
https://www.readbyqxmd.com/read/29737102/-galactomannan-tests-of-bronchoalveolar-lavage-fluid-for-diagnosing-invasive-pulmonary-aspergillosis
#14
Jin Deng, Si-Ying Wu, Ya Liu, Ying Ma, Yi Xie, Zhi-Xing Chen, Zhong-Qiu Dai, Jie-Lun Deng, Mei Kang
OBJECTIVE: To determine the value of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) for diagnosing invasive pulmonary aspergillosis. METHODS: According to the European Organization for Research and Treatment of Cancer / Invasive Fungal Infection Group (EORTC / IFICG) and the American Mycosis Research Group (MSG),and the American College of Infectious Diseases (IDSA) guidelines,295 patients with pulmonary aspergillosis (IPA) and high risk of invasive infections were divided into four groups: IPA group (42 cases),clinically diagnosed group (68 cases),suspected group (61 cases),and non-IPA group (124 cases)...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29716179/recent-update-of-the-2017-korean-association-for-the-study-of-the-liver-kasl-treatment-guidelines-of-chronic-hepatitis-c-comparison-of-guidelines-from-other-continents-2017-aasld-idsa-and-2016-easl
#15
Jong Eun Yeon
The paradigm for the treatment of chronic hepatitis C (CHC) has been changed due to the development of direct acting antivirals (DAAs) of hepatitis C virus (HCV). The high sustained virologic response rate and ease of administration makes the DAAs approach ideal to contribute to the complete eradication of HCV. Currently, treatment options for individual patients vary depending on the genotype or subtype of HCV, presence or absence of liver cirrhosis, previous experience of antiviral treatment or resistance associated substitutions...
May 2, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29715222/alpha-defensin-lateral-flow-test-for-diagnosis-of-periprosthetic-joint-infection-not-a-screening-but-a-confirmatory-test
#16
Nora Renz, Katsiaryna Yermak, Carsten Perka, Andrej Trampuz
BACKGROUND: Determination of alpha defensin in synovial fluid has shown promising results for diagnosing periprosthetic joint infection (PJI). The purposes of our study were to assess the performance of alpha defensin lateral flow (ADLF) test for the diagnosis of acute and chronic PJI using 3 classification systems and to compare its performance with the synovial fluid leukocyte count. METHODS: Patients in whom aspiration of a prosthetic hip or knee joint was performed before revision arthroplasty were prospectively included...
May 2, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29675117/adherence-to-international-guidelines-for-the-treatment-of-uncomplicated-urinary-tract-infections-in-lebanon
#17
Wissam K Kabbara, Mohamad M Meski, Wijdan H Ramadan, Dina S Maaliki, Pascale Salameh
Objective: The purpose of this study is to evaluate antibiotic-prescribing practices and adherence to IDSA guidelines for the treatment of uncomplicated urinary tract infections in Lebanon. Methods: This observational prospective study was conducted in 15 community pharmacies in Lebanon over 1 year in adult females. A regimen of nitrofurantoin 100 mg bid for 5 days or fosfomycin 3 grams single dose were considered appropriate. For the bivariate analysis, the chi-square test was used...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29668905/antimicrobial-stewardship-training-for-infectious-diseases-fellows-program-directors-identify-a-curriculum-need
#18
Vera P Luther, Rachel Shnekendorf, Lilian M Abbo, Sonali Advani, Wendy S Armstrong, Alice E Barsoumian, Cole B Beeler, Rachel Bystritsky, Kartikeya Cherabuddi, Seth Cohen, Keith W Hamilton, Dilek Ince, Julie Ann Justo, Ashleigh Logan, John B Lynch, Priya Nori, Christopher A Ohl, Payal K Patel, Paul S Pottinger, Brian S Schwartz, Conor Stack, Yuan Zhou
A needs assessment survey of Infectious Diseases (ID) training program directors identified gaps concerning comprehensive and structured educational resources for training and evaluating ID fellows in antimicrobial stewardship. An IDSA-sponsored antimicrobial stewardship core curriculum was subsequently developed to address that need.
April 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29663539/cryptococcal-infections-over-a-15-year-period-at-a-tertiary-facility-impact-of-guideline-management
#19
Ian Gassiep, Joel Douglas, Theophilus I Emeto, Katherine Crawley, Elliott G Playford
BACKGROUND: Cryptococcosis is an invasive fungal infection caused primarily by Cryptococcus neoformans and Cryptococcus gattii species, presenting predominantly as meningoencephalitis. The aim of this study is to assess all cryptococcal infections managed at our facility from 2001-2015 to determine incidence, risk factors, and comparison of outcomes prior to and following introduction of the 2010 Infectious Disease Society of America (IDSA) guidelines. METHODS: Retrospective analysis of all patients diagnosed and treated for cryptococcal infection occurring between January 2001 and December 2015...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29644966/diagnosis-and-treatment-of-neurocysticercosis-2017-clinical-practice-guidelines-by-the-infectious-diseases-society-of-america-idsa-and-the-american-society-of-tropical-medicine-and-hygiene-astmh
#20
A Clinton White, Christina M Coyle, Vedantam Rajshekhar, Gagandeep Singh, W Allen Hauser, Aaron Mohanty, Hector H Garcia, Theodore E Nash
No abstract text is available yet for this article.
April 2018: American Journal of Tropical Medicine and Hygiene
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