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https://www.readbyqxmd.com/read/29049213/clinical-characteristics-and-prognostic-risk-factors-of-healthcare-associated-pneumonia-in-a-korean-tertiary-teaching-hospital
#1
June H Ahn, Kwan H Lee, Jin H Chung, Kyeong-Cheol Shin, Choong K Lee, Hyun Jung Kim, Eun Young Choi
The 2016 American Thoracic Society and Infectious Diseases Society of America (ATS/IDSA) guidelines removed the concept of healthcare-associated pneumonia (HCAP). We examined whether the 2016 ATS/IDSA guidelines are applicable in Korea.We conducted a retrospective, observational study of pneumonia patients who were hospitalized at a tertiary teaching hospital from March 2012 to February 2014. Identified pathogens that were not susceptible to β-lactams, macrolides, and fluoroquinolones were defined as community-acquired pneumonia drug-resistant pathogens (CAP-DRPs)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29038277/dilution-factor-of-quantitative-bacterial-cultures-obtained-by-bronchoalveolar-lavage-in-patients-with-ventilator-associated-bacterial-pneumonia-implications-for-optimal-antimicrobial-therapy-ventilator-associated-bacterial-pneumonia-study-group
#2
George L Drusano, Michael L Corrado, Gino Girardi, Evelyn J Ellis-Grosse, Richard G Wunderink, Helen Donnelly, Kenneth V Leeper, Mona Brown, Tasnova Malek, Robert Duncan Hite, Michelle Ferrari, Danijela Djureinovic, Marin H Kollef, Lisa Mayfield, Ann Doyle, Jean Chastre, Alain Combes, Thomas J Walsh, Krisztina Dorizas, Hassan Alnuaimat, Brooks Edward Morgan, Jordi Rello, Cristopher Alan Mazo Torre, Ronald N Jones, Robert K Flamm, Leah Woosley, Paul G Ambrose, Sujata Bhavnani, Christopher M Rubino, Catharine C Bulik, Arnold Louie, Michael Vicchiarelli, Colleen Berman
Ventilator-Associated Bacterial Pneumonia (VABP) is a difficult therapeutic problem. Considerable controversy exists regarding the optimal chemotherapy for this entity. The recent IDSA/ATS guidelines recommended a 7-day therapeutic course for VABP based on the balance of no negative impact on all-cause mortality, less resistance emergence and fewer antibiotic days counterbalanced with a higher relapse rate for patients whose pathogen is a non-fermenter. The bacterial burden causing an infection will have a substantial impact on treatment outcome and resistance selection...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29020334/lumbar-puncture-performed-promptly-or-after-neuroimaging-in-adult-bacterial-meningitis-a-prospective-national-cohort-study-evaluating-different-guidelines
#3
Martin Glimåker, Jan Sjölin, Styrbjörn Åkesson, Pontus Naucler
Background: Early treatment is pivotal for favourable outcome in acute bacterial meningitis (ABM). Lumbar puncture (LP) is the diagnostic key. The aim was to evaluate the effect on outcome of adherence to European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), and Swedish guidelines regarding neuroimaging before LP. Methods: The cohort comprised 815 adult ABM patients in Sweden registered prospectively between 2008-2015...
September 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020263/2017-hivma-of-idsa-clinical-practice-guideline-for-the-management-of-chronic-pain-in-patients-living-with-hiv
#4
R Douglas Bruce, Jessica Merlin, Paula J Lum, Ebtesam Ahmed, Carla Alexander, Amanda H Corbett, Kathleen Foley, Kate Leonard, Glenn Jordan Treisman, Peter Selwyn
Pain has always been an important part of human immunodeficiency virus (HIV) disease and its experience for patients. In this guideline, we review the types of chronic pain commonly seen among persons living with HIV (PLWH) and review the limited evidence base for treatment of chronic noncancer pain in this population. We also review the management of chronic pain in special populations of PLWH, including persons with substance use and mental health disorders. Finally, a general review of possible pharmacokinetic interactions is included to assist the HIV clinician in the treatment of chronic pain in this population...
September 14, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020156/idsa-aasld-response-to-cochrane-review-on-direct-acting-antivirals-for-hepatitis-c
#5
William G Powderly, Susanna Naggie, Arthur Y Kim, Hugo E Vargas, Raymond T Chung, Anna S Lok
No abstract text is available yet for this article.
July 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020143/anti-infective-acquisition-costs-for-a-stewardship-program-getting-to-the-bottom-line
#6
Sarah K Parker, Amanda L Hurst, Cary Thurm, Matthew Millard, Timothy C Jenkins, Jason Child, Casey Dugan
Background: Though antimicrobial stewardship programs (ASPs) are in place for patient safety, financial justification is often required. In 2016, the Infectious Diseases Society of America (IDSA) recommended that anti-infective costs be measured by patient-level administration data normalized for patient census. Few publications use this methodology. Here, we aim to compare 3 methods of drug cost analysis during 3 phases of an ASP as an example of this recommendation's implementation...
July 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28938044/sunday-in-the-park-with-infectious-disease-workforce-mismatch-in-a-colorful-universe-of-possibilities
#7
Thomas Moore, Louise-Marie Dembry, Michael S Saag
The decline in applications for infectious diseases (ID) fellowships has been an area of active introspection for the leadership of the Infectious Disease Society of America (IDSA). This prompted actions to address the problem, including surveys of current and former fellows. Ironically, the decline in applications to ID programs is occurring at a time when the need for ID providers has never been greater and the excitement and variety in the practice of ID has never been higher. Data regarding the current ID workforce are presented here, along with perspectives about the future of the profession in the decades to come...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28936949/-clinical-practice-guidelines-of-hap-vap-in-2016-the-updates
#8
Meizhu Lu, Yan Kang
Hospital acquired pneumonia (HAP) and ventilatorassociated pneumonia (VAP) are common hospital-acquired infections with higher mortality, longer hospital stay and more hospitalization expenses. With the latest research results and evidence-based guideline methodology, Infectious Diseases Society of America (IDSA) and American Thoracic Society (ATS) have collaborated to create updated guidelines for the diagnosis and treatment of HAP and VAP in 2016. It is worth critically reading and thinking that most recommendations are supported by low-quality or very-low quality evidence and some strong recommendations is different from the actual clinical work in China...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28936146/adherence-to-clinical-practice-guidelines-for-the-treatment-of-candidemia-at-a-veterans-affairs-medical-center
#9
Chester N Ashong, Andrew S Hunter, M David Mansouri, Richard M Cadle, Richard J Hamill, Daniel M Musher
OBJECTIVES: The primary objective of this study was to examine the appropriateness of candidemia management at a Veterans Affairs Medical Center as recommended by the 2009 Infectious Diseases Society of America (IDSA) guidelines for treatment of Candida infections. METHODS: A retrospective analysis of 94 adult patients with blood cultures positive for Candida spp. was performed. Patients were stratified by severity of disease into two groups: non-neutropenic, mild-moderate disease (Group 1, n = 54, 56%) and non-neutropenic, moderate-severe disease (Group 2, n = 40, 42%)...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28882012/empirical-treatment-of-adults-with-hospital-acquired-pneumonia-lights-and-shadows-of-the-2016-clinical-practice-ats-idsa-guidelines
#10
REVIEW
M Vacas-Córdoba, C Cardozo-Espinola, P Puerta-Alcalde, C Cilloniz, A Torres, C García-Vidal
Hospital-acquired pneumonia (HAP) is a common cause of nosocomial infection associated with significant morbidity and mortality. New clinical practice guidelines for the management of adults with hospital-acquired pneumonia have been published in 2016 by the Infectious Diseases Society of America (IDSA) and the American Thoracic Society (ATS). This review focuses on the recent recommendations and their limitations. We also focus on new therapeutic options that might improve the treatment and outcomes of these patients...
September 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28882011/comments-on-practice-guidelines-for-the-diagnosis-and-management-of-aspergillosis-made-by-the-idsa-in-2016
#11
REVIEW
E Alarcón-Manoja, C Cardozo-Espinola, P Puerta-Alcalde, C García-Vidal
We sought to review the most important updates in the treatment of aspergillosis after the publication of the clinical practice guidelines for the diagnosis and management of invasive aspergillosis (IA) by the Infectious Diseases Society of America. Our aim is to discuss some of the key aspects concerning the following topics: early initiation of antifungal therapy, antifungal agent of choice, follow-up of patients with IA, and breakthrough aspergillosis.
September 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28730159/antibiotic-prescribing-for-adults-hospitalized-in-the-etiology-of-pneumonia-in-the-community-study
#12
Sara Tomczyk, Seema Jain, Anna M Bramley, Wesley H Self, Evan J Anderson, Chris Trabue, D Mark Courtney, Carlos G Grijalva, Grant W Waterer, Kathryn M Edwards, Richard G Wunderink, Lauri A Hicks
BACKGROUND: Community-acquired pneumonia (CAP) 2007 guidelines from the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) recommend a respiratory fluoroquinolone or beta-lactam plus macrolide as first-line antibiotics for adults hospitalized with CAP. Few studies have assessed guideline-concordant antibiotic use for patients hospitalized with CAP after the 2007 IDSA/ATS guidelines. We examine antibiotics prescribed and associated factors in adults hospitalized with CAP...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28678546/mortality-prediction-using-serum-biomarkers-and-various-clinical-risk-scales-in-community-acquired-pneumonia
#13
Min Woo Kim, Jee Yong Lim, Sang Hoon Oh
We evaluated the predictive value of serum biomarkers and various clinical risk scales for the 28-day mortality of community-acquired pneumonia (CAP). Serum biomarkers including procalcitonin (PCT) and C-reactive protein (CRP) were evaluated in the emergency department. Scores for the pneumonia severity index (PSI); CURB65 (confusion, urea, respiration, blood pressure; age >65 years); Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) guidelines for severe CAP; Acute Physiology, Chronic Health Evaluation (APACHE) II; Sequential Organ Failure Assessment (SOFA); and quick SOFA (qSOFA) were calculated...
November 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28677020/treatment-discontinuation-adherence-and-real-world-effectiveness-among-patients-treated-with-ledipasvir-sofosbuvir-in-the-united-states
#14
Amy Puenpatom, Michael Hull, Jeffrey McPheeters, Kay Schwebke
INTRODUCTION: Ledipasvir/sofosbuvir (LDV/SOF) for hepatitis C virus (HCV) treatment provides an oral interferon-free treatment regimen with high rates of sustained virologic response (SVR). This study assessed treatment discontinuation, factors associated with treatment completion, and real-world effectiveness. METHODS: Patients with HCV treated with LDV/SOF between October 2014 and June 2015 and enrolled in a large US health plan were identified. Expected treatment duration was calculated based on IDSA/AASLD treatment guidelines and US labels using data for genotype, initial treatment regimen, baseline cirrhosis, and prior treatments...
July 4, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28657261/rare-case-of-non-tuberculous-mycobacterium-a-diagnostic-dilemma
#15
N Marathe, B Canavan
Non-Tuberculous Mycobacterial (NTM) infections occur in HIV-negative patients with or without underlying lung disease. It is generally felt that these organisms are acquired from the environment. Unlike tuberculosis, there are no convincing data demonstrating human-to-human OR animal-to-human transmission of NTM. We report a case of NTM infection in a 38 year old patient with underlying emphysematous lung disease. The case highlights the diagnostic dilemma which occurs when persistent sputum Acid- Fast Bacilli (AFB) smears are positive, but Nucleic acid amplification test is negative...
February 10, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28625166/impact-of-gram-stain-results-on-initial-treatment-selection-in-patients-with-ventilator-associated-pneumonia-a-retrospective-analysis-of-two-treatment-algorithms
#16
Jumpei Yoshimura, Takahiro Kinoshita, Kazuma Yamakawa, Asako Matsushima, Naoki Nakamoto, Toshimitsu Hamasaki, Satoshi Fujimi
BACKGROUND: Ventilator-associated pneumonia (VAP) is a common and serious problem in intensive care units (ICUs). Several studies have suggested that the Gram stain of endotracheal aspirates is a useful method for accurately diagnosing VAP. However, the usefulness of the Gram stain in predicting which microorganisms cause VAP has not been established. The purpose of this study was to evaluate whether a Gram stain of endotracheal aspirates could be used to determine appropriate initial antimicrobial therapy for VAP...
June 19, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28578710/compliance-with-clostridium-difficile-treatment-guidelines-effect-on-patient-outcomes
#17
K T Crowell, K G Julian, M Katzman, A S Berg, A Tinsley, E D Williams, W A Koltun, E Messaris
Guidelines for the severity classification and treatment of Clostridium difficile infection (CDI) were published by Infectious Diseases Society of America (IDSA)/Society for Healthcare Epidemiology of America (SHEA) in 2010; however, compliance and efficacy of these guidelines has not been widely investigated. This present study assessed compliance with guidelines and its effect on CDI patient outcomes as compared with before these recommendations. A retrospective study included all adult inpatients with an initial episode of CDI treated in a single academic center from January 2009 to August 2014...
August 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28577158/adherence-to-clinical-practice-guidelines-for-the-management-of-clostridium-difficile-infection-in-japan-a-multicenter-retrospective-study
#18
K Kobayashi, N Sekiya, Y Ainoda, H Kurai, A Imamura
This study was conducted to investigate the adherence to clinical practice guidelines (CPGs) for Clostridium difficile infection (CDI). A retrospective multicenter observational study was conducted via chart review at four teaching hospitals in Japan from April 2012 through September 2013. CDI was diagnosed based on positive identification of CD toxin by enzyme immunoassay testing. CDI patients were divided into non-severe and severe groups according to the severity criteria of four published guidelines (SHEA/IDSA 2010, ACG 2013, ESCMID 2009, HPA/DH 2008)...
June 2, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28501465/candiduria-evidence-based-approach-to-management-are-we-there-yet
#19
REVIEW
W A Alfouzan, R Dhar
Candiduria is considered one of the most controversial issues in patient management. Neither the diagnosis nor the optimal treatment options are standardized. This is further complicated by lack of defined laboratory criteria for diagnosis as most of the studies were set for bacterial rather than fungal urinary tract infection (UTI). Furthermore, since Candida species is a known commensal of the genitourinary tract its presence in the urine sample adds ambiguity to making a definitive diagnosis of candidal UTI...
May 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28480249/a-proposed-new-classification-of-skin-and-soft-tissue-infections-modeled-on-the-subset-of-diabetic-foot-infection
#20
REVIEW
Benjamin A Lipsky, Michael H Silverman, Warren S Joseph
Schemes for classifying skin and soft tissue infections (SSTIs) pose limitations for clinicians and regulatory agencies. Diabetic foot infections (DFIs) are a subset of SSTIs. We developed and are proposing a classification to harmonize current schemes for SSTIs and DFIs. Existing schemes for classifying SSTIs are limited in both their usefulness to clinicians and to regulatory agencies. The guidelines on SSTI from the Infectious Diseases Society of America (IDSA) and the guidance from the US Food and Drug Administration do not adequately address many types of wound infections...
2017: Open Forum Infectious Diseases
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