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Siti Sarwani Putri Mohamed Isa, Abdulwali Ablat, Jamaludin Mohamad
Plumeria rubra Linn of the family Apocynaceae is locally known in Malaysia as "Kemboja". It has been used by local traditional medicine practitioners for the treatment of arthritis-related disease. The LCMS/MS analysis of the methanol extract of flowers (PR-ME) showed that it contains 3- O -caffeyolquinic acid, 5-caffeoquinic acid, 1,3-dicaffeoquinic acid, chlorogenic acid, citric acid, 3,3-di- O -methylellagic acid, kaempferol-3- O -glucoside, kaempferol-3-rutinoside, kaempferol, quercetin 3- O -α-l-arabinopyranoside, quercetin, quinic acid and rutin...
February 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Helen L Alvarado, Ana C Calpena, Maria L Garduno-Ramirez, Raul Ortiz, Consolacion Melguizo, Jose M Prados, Beatriz Clares
BACKGROUND: Triterpenoids are an important class of natural bioactive products present in many medicinal plants. OBJECTIVE: The aim of present study is to investigate the antioxidant and anticarcinogenic potential of oleanolic acid (OA) and ursolic acid (UA) on B16 murine melanoma cell line isolated from Plumeria obtusa, free and loaded in a nanoemulsion (NEm) system. METHOD: The nanoemulsion was characterized by dynamic light scattering, transmission electron microscopy...
January 11, 2018: Anti-cancer Agents in Medicinal Chemistry
Ghadah A Alhozaimy, Ebtesam Saad Al-Sheddi, Taghreed A Ibrahim
Background: Plumeria acutifolia ( Apocynaceae ) is an ornamental plant, used in the traditional medicine and known to have a variety of constituents as alkaloids, flavonoids, and iridoids. Extracts of this plant were proved to have antimicrobial and anticancer activities. Objectives: This research was conducted for the evaluation of the biological activities of P. acutifolia stem bark and isolation and structural elucidation of various chemical compounds from the biologically active fractions...
October 2017: Pharmacognosy Magazine
Lucas de Araújo Bastos Santana, Diego Passos Aragão, Thiago de Souza Lopes Araújo, Nayara Alves de Sousa, Luan Kelves Miranda de Souza, Lucas Eduardo Silva Oliveira, Anna Carolina Toledo da Cunha Pereira, Gustavo Portela Ferreira, Naylla Veras de Moraes Oliveira, Bruna da Silva Souza, Francisca Beatriz Melo Sousa, Márcio Viana Ramos, Cleverson Diniz Teixeira de Freitas, Jand-Venes Rolim Medeiros, Jefferson Soares de Oliveira
The water-soluble protein fraction obtained from Plumeria pudica (LPPp) latex has previously been demonstrated to have anti-inflammatory and antinociceptive effects. In the present study, LPPp was tested for activity against diarrhea induced by castor oil, prostaglandin E2 (PGE2 ) or cholera toxin. Different doses of LPPp (10, 20 or 40mg/kg) significantly inhibited the percentage of diarrheal stools (31.18%, 42.97% and 59.70%, respectively) induced by castor oil. This event was followed by significant reduction of both intestinal fluid accumulation (31...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Afnan Sh Ahmed, Qamaruddin Ahmed, Anil Kumar Saxena, Parveen Jamal
Inhibition of intestinal α-amylase and α-glucosidase is an important strategy to regulate diabetes mellitus (DM). Antioxidants from plants are widely regarded in the prevention of diabetes. Fruits of Elettaria cardamomum (L.) Maton (Zingiberaceae) and Piper cubeba L. f. (Piperaceae) and flowers of Plumeria rubra L. (Apocynaceae) are traditionally used to cure DM in different countries. However, the role of these plants has been grossly under reported and is yet to receive proper scientific evaluation with respect to understand their traditional role in the management of diabetes especially as digestive enzymes inhibitors...
January 2017: Pakistan Journal of Pharmaceutical Sciences
David J Portman, Louise Brown, James Yuan, Robert Kissling, Sheryl A Kingsberg
BACKGROUND: Hypoactive sexual desire disorder (HSDD) is a common sexual disorder in younger and older women. Flibanserin is approved for the treatment of acquired generalized HSDD in premenopausal women only. The efficacy of flibanserin for postmenopausal women with HSDD was demonstrated in the first of two North American randomized, double-blinded, placebo-controlled trials (SNOWDROP). AIM: To evaluate the safety and efficacy of flibanserin in postmenopausal women with HSDD in a second randomized, double-blinded, placebo-controlled trial (PLUMERIA)...
June 2017: Journal of Sexual Medicine
Spencer B King
No abstract text is available yet for this article.
March 27, 2017: JACC. Cardiovascular Interventions
Wangyu Liu, Yuanqiang Luo, Li Wang, Tao Luo, Yi Peng, Lei Wu
As an exploration to the nature, research about plants' physiological properties have never been suspended. Water transport in leaf vein systems is an essential part of plant growth and development. In this paper, a simple but efficient method combined the fluorescence labeling technology frequently used in bioresearch and the image-processing technology in the computer realm was developed to measure the flow velocity, which was used as a quantitative description to reveal the regulation of water transport in leaf vein systems...
October 1, 2016: Journal of Plant Physiology
Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck Chan
Apocynaceae is a large family of tropical trees, shrubs and vines with most species producing white latex. Major metabolites of species are triterpenoids, iridoids, alkaloids and cardenolides, which are known for a wide range of biological and pharmacological activities such as cardioprotective, hepatoprotective, neuroprotective, anti-inflammatory, anticancer and antimalarial properties. Prompted by their anticancer and antimalarial properties, the current knowledge on ten genera (Allamanda, Alstonia, Calotropis, Catharanthus, Cerbera, Dyera, Kopsia, Nerium, Plumeria and Vallaris) is updated...
July 2016: Journal of Integrative Medicine
Kaomud Tyagi, Vikas Kumar
Two new species of Neohydatothrips are described from India, N. chandrai and N. plumeria. The former was collected on leaves of a hedge plant in northwest India, and the latter on flowers and leaves of Plumeria sp. in eastern India. A key to the seven species of Neohydatothrips recorded from India is also provided. Partial sequence data of mitochondrial cytochrome <span style="text-decoration: underline;">c oxidase (mtCOI) from the holotypes of each of these two new species were generated.
June 30, 2016: Zootaxa
Tao-yang Huang, Yan-jun Weng, He Huang, Qiu-ling Xie, Cong-hui Yan, Wei Zhao
OBJECTIVE: To compare the volatile constituents of Plumeriae Flos from different origins. METHODS: Water distillation method according to the Chinese Pharmacopeia was used to extract the volatile constituents of fresh Plumeriae Flos samples (red flower and white flower) and dried samples. GC-MS method combined with NIST MS Search 2.0 data base was carried out to identify the volatile constituents and to calculate the relative percentage content. RESULTS: 55 peaks were detected in the GC-MS spectrum...
November 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Nittya K Dogra
Plumeria (Apocynaceae) is a genus comprising mostly of lactiferous trees and deciduous shrubs. Plumeria obtusa L. is a widely available but pharmacologically lesser explored species of this genus. Thus, present research was undertaken to determine the phytochemical constituents and the antioxidant potential of the methanol extract and fractions of the plant. The antioxidant potential was determined using 1,1-diphenyl-2-picrylhydrazyl radical scavenging and inhibition of lipid peroxidation assay.
January 2016: Indian Journal of Pharmaceutical Sciences
Alok Kumar, Vikas Solanki, H N Verma, Bikash Mandal
Frangipani mosaic virus (FrMV) is known to infect frangipani tree (Plumeria rubra f. acutifolia) in India but the virus has not been characterized at genomic level and diagnosis is not available. In the present study, an isolate of FrMV (FrMV-Ind-1) showing greenish mosaic and vein-banding symptoms in P. rubra f. acutifolia in New Delhi was characterized based on host reactions, serology and genome sequence. The virus isolate induced local symptoms on several new experimental host species: Capsicum annuum (chilli), Nicotiana benthamiana, Solanum lycopersicum and S...
October 2015: Virus Genes
Cleverson D T Freitas, Maria Z R Silva, Frederico Bruno-Moreno, Ana C O Monteiro-Moreira, Renato A Moreira, Márcio V Ramos
Proteins that share similar primary sequences to the protein originally described in salt-stressed tobacco cells have been named osmotins. So far, only two osmotin-like proteins were purified and characterized of latex fluids. Osmotin from Carica papaya latex is an inducible protein lacking antifungal activity, whereas the Calotropis procera latex osmotin is a constitutive antifungal protein. To get additional insights into this subject, we investigated osmotins in latex fluids of five species. Two potential osmotin-like proteins in Cryptostegia grandiflora and Plumeria rubra latex were detected by immunological cross-reactivity with polyclonal antibodies produced against the C...
November 2015: Plant Physiology and Biochemistry: PPB
Rani Mata, Jayachandra Reddy Nakkala, Sudha Rani Sadras
Herein, we report the green synthesis of silver nanoparticles using Plumeria alba (frangipani) flower extract (FFE) and their biological applications. The formation of frangipani silver nanoparticles (FSNPs) was confirmed by UV-visible spectroscopy and characterized by DLS particle size analyzer, SEM/EDAX, FTIR, TGA/DSC and XRD. The synthesized spherical FSNPs were found to be 36.19nm in size as determined by DLS particle size analyzer. EDAX data and XRD pattern of FSNPs confirmed the presence and face-centered cubic (fcc) phase structure of silver...
June 2015: Materials Science & Engineering. C, Materials for Biological Applications
N Ali, M Junaid, D Ahmad, M urRahman, N Ali, G Katzenmeier
Extracts of Plumeria obtusa are widely used in ethnomedicine and have been investigated for a variety of biological activities; however, the antimicrobial activity of P. obtusa flowers is poorly characterized. In this study, the antimicrobial activities of different solvents (petroleum ether, ethyl acetate, chloroform, isobutanol and ethanol) extracts from flowers of P. obtusa were investigated by a disc diffusion method against Gram-positive bacteria, Gram-negative bacteria and a fungus. All extracts exhibited growth inhibition of all microorganisms at variable degrees as measured by relative zones of inhibition, however, the petroleum ether extract was ineffective against Klebsiella pneumonia and ethyl acetate and isobutanol extracts were ineffective against Pseudomonas aeruginosa...
December 2014: Tropical Biomedicine
Helen L Alvarado, Guadalupe Abrego, María L Garduño-Ramirez, Beatriz Clares, María L García, Ana C Calpena
Oleanolic acid (OA) and ursolic acid (UA) are ubiquitous pentacyclic triterpenes compounds in plants. These triterpenoids exhibit unique, important biological and pharmacological activities. For the investigation and development of topical drug delivery systems of triterpenoids in Plumeria obtusa is essential an adequate detection and quantification method for its application in skin permeation studies. The aim of this study was to develop a HPLC method for the determination of OA/UA from leaves of P. obtusa...
March 1, 2015: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Nasir Ali, Dawood Ahmad, Jehan Bakht
The present research work was carried out to investigate the antimicrobial (eight bacteria and one fungus) activities of different solvent (ethanol, petroleum ether, chloroform, ethyl acetate and isobutanol) extracted samples from flowers of P. obstusa by disc diffusion method. Analysis of the data revealed that all the five extracts from flowers of P. obstusa showed different ranges of antimicrobial activities. Petroleum ether fractions showed inhibitory activities against all the nine microbial species except Klebsiella pneumonia...
January 2015: Pakistan Journal of Pharmaceutical Sciences
Oladipupo A Lawal, Isiaka A Ogunwande, Andy R Opoku
This paper reports on the compounds identified in the leaf and flower essential oils obtained by hydrodistillation of Plumeria alba L. (Apocynaceae) grown in Nigeria. The chemical analysis of the essential oils was achieved by means of gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS). Linalool (13.2%), n-nonanal (9.6%), phenyl acetaldehyde (8.5%), neryl acetone (5.3%) and n-decanal (5.1%) were the main constituents of the leaf oil. On the other hand, the flower oil comprised mainly of limonene (9...
November 2014: Natural Product Communications
Márcio V Ramos, Danielle A Pereira, Diego P Souza, Maria-Lídia S Silva, Luciana M R Alencar, Jeanlex S Sousa, Juliany-Fátima N Queiroz, Cleverson D T Freitas
Studies investigating the resistance-susceptibility of crop insects to proteins found in latex fluids have been reported. However, latex-bearing plants also host insects. In this study, the gut proteolytic system of Pseudosphinx tetrio, which feeds on Plumeria rubra leaves, was characterized and further challenged against the latex proteolytic system of its own host plant and those of other latex-bearing plants. The gut proteolytic system of Danaus plexippus (monarch) and the latex proteolytic system of its host plant (Calotropis procera) were also studied...
January 2015: Planta
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