keyword
MENU ▼
Read by QxMD icon Read
search

Optic cup development

keyword
https://www.readbyqxmd.com/read/29144417/fast-low-cost-and-non-destructive-physico-chemical-analysis-of-virgin-olive-oils-using-near-infrared-reflectance-spectroscopy
#1
Ana Garrido-Varo, María-Teresa Sánchez, María-José De la Haba, Irina Torres, Dolores Pérez-Marín
Near-Infrared (NIR) Spectroscopy was used for the non-destructive assessment of physico-chemical quality parameters in olive oil. At the same time, the influence of the sample presentation mode (spinning versus static cup) was evaluated using two spectrophotometers with similar optical characteristics. A total of 478 olive oil samples were used to develop calibration models, testing various spectral signal pre-treatments. The models obtained by applying MPLS regression to spectroscopic data yielded promising results for olive oil quality measurements, particularly for acidity, the peroxide index and alkyl and ethyl ester content...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29076672/determination-of-association-of-pigmentary-glaucoma-with-pigment-dispersion-syndrome
#2
Imtiaz Ali Shah, Shujaat Ali Shah, Partab Rai Nagdev, Safdar Ali Abbasi, Naeem Ali Abbasi, Safdar Akhtar Katpar
BACKGROUND: Pigment Dispersion Syndrome (PDS) is an autosomal dominant disorder of white males between 20 to 40 years of age characterized by deposition of pigment on the lens, zonules of lens, trabecular meshwork and corneal endothelium (Krukenberg's spindle) in addition to radial, spoke like transillumination defects in the mid peripheral iris. This study was conducted to determine the frequency of occurrence of Pigmentary Glaucoma in patients with Pigment Dispersion Syndrome (PDS)...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28984709/measurement-of-optic-disc-cup-surface-depth-using-cirrus-hd-oct
#3
Young Kook Kim, Ahnul Ha, Won June Lee, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To introduce the measurement method of optic disc cup surface depth using spectral-domain optical coherence tomography (SD-OCT) and then evaluate the rates of cup surface depression at three different stages of glaucoma. METHODS: We retrospectively identified 52 eyes with preperimetric glaucoma, 56 with mild-or-moderate glaucoma and 50 with severe glaucoma and followed them for at least 48 months. Eyes were imaged using SD-OCT (Cirrus™ HD-OCT) at 12-month intervals...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28947898/an-automatic-image-processing-system-for-glaucoma-screening
#4
Ahmed Almazroa, Sami Alodhayb, Kaamran Raahemifar, Vasudevan Lakshminarayanan
Horizontal and vertical cup to disc ratios are the most crucial parameters used clinically to detect glaucoma or monitor its progress and are manually evaluated from retinal fundus images of the optic nerve head. Due to the rarity of the glaucoma experts as well as the increasing in glaucoma's population, an automatically calculated horizontal and vertical cup to disc ratios (HCDR and VCDR, resp.) can be useful for glaucoma screening. We report on two algorithms to calculate the HCDR and VCDR. In the algorithms, level set and inpainting techniques were developed for segmenting the disc, while thresholding using Type-II fuzzy approach was developed for segmenting the cup...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28914615/apoptosis-generates-mechanical-forces-that-close-the-lens-vesicle-in-the-chick-embryo
#5
Alina Oltean, Larry A Taber
During the initial stages of eye development, optic vesicles grow laterally outward from both sides of the forebrain and come into contact with the surrounding surface ectoderm (SE). Within the region of contact, these layers then thicken locally to create placodes and invaginate to form the optic cup (primitive retina) and lens vesicle (LV), respectively. This paper examines the biophysical mechanisms involved in LV formation, which consists of three phases: (1) lens placode formation; (2) invagination to create the lens pit (LP); and (3) closure to form a complete ellipsoidally shaped LV...
September 15, 2017: Physical Biology
https://www.readbyqxmd.com/read/28904534/three-dimensional-organoid-system-transplantation-technologies-in-future-treatment-of-central-nervous-system-diseases
#6
REVIEW
NaiLi Wei, ZiFang Quan, Hailiang Tang, JianHong Zhu
In recent years, scientists have made great achievements in understanding the development of human brain and elucidating critical elements of stepwise spatiotemporal control strategies in neural stem cell specification lineage, which facilitates successful induction of neural organoid in vitro including the cerebral cortex, cerebellar, neural tube, hippocampus cortex, pituitary, and optic cup. Besides, emerging researches on neural organogenesis promote the application of 3D organoid system transplantation in treating central nervous system (CNS) diseases...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28867048/signaling-and-gene-regulatory-networks-in-mammalian-lens-development
#7
REVIEW
Ales Cvekl, Xin Zhang
Ocular lens development represents an advantageous system in which to study regulatory mechanisms governing cell fate decisions, extracellular signaling, cell and tissue organization, and the underlying gene regulatory networks. Spatiotemporally regulated domains of BMP, FGF, and other signaling molecules in late gastrula-early neurula stage embryos generate the border region between the neural plate and non-neural ectoderm from which multiple cell types, including lens progenitor cells, emerge and undergo initial tissue formation...
October 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28864288/a-novel-hypothesis-for-the-pathogenesis-of-glaucomatous-disc-hemorrhage
#8
REVIEW
Eun Jung Lee, Jong Chul Han, Changwon Kee
Disc hemorrhage is known to be associated with glaucoma development and progression. Several hypotheses have been proposed to explain the pathogenesis of disc hemorrhage in glaucoma, including mechanical and ischemic theories. However, no theory has yet provided a clear explanation of cellular-level events and related histologic findings. Moreover, research has yet to elucidate why glaucomatous disc hemorrhage occurs around the optic disc and at the margin of the retinal nerve fiber layer defect. Understanding the pathogenic mechanism of disc hemorrhage will facilitate interpretation of its clinical importance, and provide better insight into clinical practice...
August 30, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28839011/eye-and-heart-morphogenesis-are-dependent-on-melatonin-signaling-in-chick-embryos
#9
Renato C Nogueira, Lucia de Fatima S Sampaio
Calmodulin is vital for chick embryos morphogenesis in the incubation time 48-66 h when the rudimentary C-shaped heart attains an S-shaped pattern and the optic vesicles develop into optic cups. Melatonin is in the extraembryonic yolk sac of the avian egg; melatonin binds calmodulin. The aim of this study was to investigate the function of melatonin in the formation of the chick embryo optic cups and S-shaped heart, by pharmacological methods and immunoassays. Mel1a melatonin receptor immunofluorescence was distributed in the optic cups and rudimentary hearts...
October 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28815393/pattern-noise-pano-a-new-automated-functional-glaucoma-test
#10
Sylvain El-Khoury, Thomas Hannen, Diana Carmen Dragnea, Faustin Ngounou, Paul-Rolf Preußner
PURPOSE: To present a newly developed visual field device (pattern noise: PANO) designed to be sensitive to glaucoma defects, cost-effective, material-practical and easy to repair and therefore particularly suited for low-income countries, where glaucoma can be highly prevalent (e.g. sub-Saharan Africa). METHODS: This is primarily a descriptive paper, but it also includes a prospective matched case-control pilot study. Hardware, stimulus, target configuration, testing strategy and result sheet are described...
August 16, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28783216/sensitive-quantitative-naked-eye-biodetection-with-polyhedral-cu-nanoshells
#11
Jae-Ho Kim, Jeong-Eun Park, Mouhong Lin, Sungi Kim, Gyeong-Hwan Kim, SungJun Park, GwangPyo Ko, Jwa-Min Nam
One of the most heavily used methods in chemical and biological labeling, detection, and imaging is based on silver shell-based enhancement on Au nanoparticles (AuNPs) that is useful for amplifying Rayleigh scattering, colorimetric signal, surface-enhanced Raman scattering, and electrical signal, but poor structural controllability and nonspecific growth of silver shells have limited its applications, especially with respect to signal reproducibility and quantification. Here, a highly specific, well-defined Cu nanopolyhedral shell overgrowth chemistry is developed with the aid of polyethyleneimine (PEI) on AuNPs, and the use of this PEI-mediated Cu polyhedral nanoshell (CuP) chemistry is shown as a means of light-scattering signal enhancement for the development of naked-eye-based highly sensitive and quantitative detections of DNA and viruses...
August 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28729440/the-transcription-factor-foxg1-promotes-optic-fissure-closure-in-the-mouse-by-suppressing-wnt8b-in-the-nasal-optic-stalk
#12
Rowena Smith, Yu-Ting Huang, Tian Tian, Dominika Vojtasova, Oscar Mesalles-Naranjo, Steven M Pollard, Thomas Pratt, David J Price, Vassiliki Fotaki
During vertebrate eye morphogenesis, a transient fissure forms at its inferior part, known as the optic fissure. This will gradually close, giving rise to a healthy, spherical optic cup. Failure of the optic fissure to close gives rise to an ocular disorder known as coloboma. During this developmental process, Foxg1 is expressed in the optic neuroepithelium, with highest levels of expression in the nasal optic stalk. Foxg1(-/-) mutant mice have microphthalmic eyes with a large ventral coloboma. We found Wnt8b expression upregulated in the Foxg1(-/-) optic stalk and hypothesized that, similar to what is observed in telencephalic development, Foxg1 directs development of the optic neuroepithelium through transcriptional suppression of Wnt8b To test this, we generated Foxg1(-/-);Wnt8b(-/-) double mutants of either sex and found that the morphology of the optic cup and stalk and the closure of the optic fissure were substantially rescued in these embryos...
August 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28717659/identification-and-characterization-of-variants-and-a-novel-4%C3%A2-bp-deletion-in-the-regulatory-region-of-six6-a-risk-factor-for-primary-open-angle-glaucoma
#13
Mohd Hussain Shah, Noemi Tabanera, Subbaiah Ramasamy Krishnadas, Manju R Pillai, Paola Bovolenta, Periasamy Sundaresan
BACKGROUND: Primary open-angle glaucoma (POAG) is a complex disease of multigenic inheritance and the most common subtype of glaucoma. SIX6 encodes a transcription factor involved in retina, optic nerve, and pituitary development. Previous studies showed a genetic association between the SIX6 locus and POAG, identifying risk alleles. Whether these alleles are present also in the south Indian population is unclear. METHODS: To address this question, the SIX6 gene and an already characterized and highly conserved SIX6 enhancer (Ch14:60974427-60974430) were sequenced in two south Indian cohorts, respectively, composed of 65/65 and 200/200 POAG cases/age-matched controls...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28700940/in%C3%A2-vitro-modeling-using-ciliopathy-patient-derived-cells-reveals-distinct-cilia-dysfunctions-caused-by-cep290-mutations
#14
Hiroko Shimada, Quanlong Lu, Christine Insinna-Kettenhofen, Kunio Nagashima, Milton A English, Elizabeth M Semler, Jacklyn Mahgerefteh, Artur V Cideciyan, Tiansen Li, Brian P Brooks, Meral Gunay-Aygun, Samuel G Jacobson, Tiziana Cogliati, Christopher J Westlake, Anand Swaroop
Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD). We examined cilia biogenesis and function in cells derived from CEP290-LCA and CEP290-JSRD patients. CEP290 protein was reduced in LCA fibroblasts with no detectable impact on cilia; however, optic cups derived from induced pluripotent stem cells (iPSCs) of CEP290-LCA patients displayed less developed photoreceptor cilia. Lack of CEP290 in JSRD fibroblasts resulted in abnormal cilia and decreased ciliogenesis...
July 11, 2017: Cell Reports
https://www.readbyqxmd.com/read/28700125/optical-assessment-of-mammographic-breast-density-by-a-12-wavelength-versus-a-continuous-spectrum-optical-spectroscopy-device
#15
E Jane Walter, Lothar Lilge
A 12-laser-wavelength, fixed source-detector position, cup-based optical breast spectroscopy (OBS) device was developed for use in large-scale, multi-center trials as a mammographic breast density (MBD) quantification and breast cancer risk pre-screening tool. In this study, the device was evaluated in comparison with a spectrometer-based device used in previous studies. The devices were compared on their ability to predict mammographic percent density (MPD) and to identify women with high MBD from optical spectra...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28576690/complement-component-c3ar-constitutes-a-novel-regulator-for-chick-eye-morphogenesis
#16
Erika Grajales-Esquivel, Agustin Luz-Madrigal, Jeffrey Bierly, Tracy Haynes, Edimara S Reis, Zeyu Han, Christian Gutierrez, Zachary McKinney, Apostolia Tzekou, John D Lambris, Panagiotis A Tsonis, Katia Del Rio-Tsonis
Complement components have been implicated in a wide variety of functions including neurogenesis, proliferation, cell migration, differentiation, cancer, and more recently early development and regeneration. Following our initial observations indicating that C3a/C3aR signaling induces chick retina regeneration, we analyzed its role in chick eye morphogenesis. During eye development, the optic vesicle (OV) invaginates to generate a bilayer optic cup (OC) that gives rise to the retinal pigmented epithelium (RPE) and neural retina...
August 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28556369/retinal-pigment-epithelium-expansion-around-the-neural-retina-occurs-in-two-separate-phases-with-distinct-mechanisms
#17
Paula Bernice Cechmanek, Sarah McFarlane
BACKGROUND: The retinal pigment epithelium (RPE) is a specialized monolayer of epithelial cells that forms a tight barrier surrounding the neural retina. RPE cells are indispensable for mature photoreceptor renewal and survival, yet how the initial RPE cell population expands around the neural retina during eye development is poorly understood. RESULTS: Here we characterize the differentiation, proliferation, and movements of RPE progenitors in the Zebrafish embryo over the period of optic cup morphogenesis...
May 27, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28546339/bmp-induced-reprogramming-of-the-neural-retina-into-retinal-pigment-epithelium-requires-wnt-signalling
#18
Jörg Steinfeld, Ichie Steinfeld, Alexander Bausch, Nicola Coronato, Meggi-Lee Hampel, Heike Depner, Paul G Layer, Astrid Vogel-Höpker
In vertebrates, the retinal pigment epithelium (RPE) and photoreceptors of the neural retina (NR) comprise a functional unit required for vision. During vertebrate eye development, a conversion of the RPE into NR can be induced by growth factors in vivo at optic cup stages, but the reverse process, the conversion of NR tissue into RPE, has not been reported. Here, we show that bone morphogenetic protein (BMP) signalling can reprogram the NR into RPE at optic cup stages in chick. Shortly after BMP application, expression of Microphthalmia-associated transcription factor (Mitf) is induced in the NR and selective cell death on the basal side of the NR induces an RPE-like morphology...
July 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28372636/concerted-action-of-neuroepithelial-basal-shrinkage-and-active-epithelial-migration-ensures-efficient-optic-cup-morphogenesis
#19
Jaydeep Sidhaye, Caren Norden
Organ formation is a multi-scale event that involves changes at the intracellular, cellular and tissue level. Organogenesis often starts with the formation of characteristically shaped organ precursors. However, the cellular mechanisms driving organ precursor formation are often not clear. Here, using zebrafish, we investigate the epithelial rearrangements responsible for the development of the hemispherical retinal neuroepithelium (RNE), a part of the optic cup. We show that in addition to basal shrinkage of RNE cells, active migration of connected epithelial cells into the RNE is a crucial player in its formation...
April 4, 2017: ELife
https://www.readbyqxmd.com/read/28361307/generation-of-a-three-dimensional-retinal-tissue-from-self-organizing-human-esc-culture
#20
Atsushi Kuwahara, Tokushige Nakano, Mototsugu Eiraku
A three-dimensional (3D) tissue generated in vitro is a promising source to study developmental biology and regenerative medicine. In the last decade, Yoshiki Sasai's group have developed a 3D stem cell culture technique known as SFEBq and demonstrated that embryonic stem cells (ESCs) have an ability to self-organize stratified neural tissue including 3D-retina. Furthermore, we have reported that ESC-derived retinal tissue can form an optic cup and a ciliary margin, which are unique structures in the developing retina...
2017: Methods in Molecular Biology
keyword
keyword
42146
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"