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https://www.readbyqxmd.com/read/28650951/development-and-progression-of-a-lamellar-macular-hole-with-lamellar-hole-associated-epiretinal-proliferation
#1
Denise Compera, Matteo G Cereda, Ricarda G Schumann, Ferdinando Bottoni
PURPOSE: To describe evolution and progression of a lamellar macular hole (LMH) with "lamellar hole-associated epiretinal proliferation (LHEP)" using spectral-domain optical coherence tomography and fundus autofluorescence. METHODS: Observational case report. RESULTS: We report on a 63-year-old male patient demonstrating a complete history of LMH development with LHEP occurring during a follow-up period of 8 years. Presenting with a normal foveal contour and attached posterior vitreous at first visit, an LMH developed shortly after incomplete posterior vitreous detachment with vitreopapillary adhesion...
June 23, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28650720/nonclinical-development-of-env905-difluprednate-ophthalmic-implant-for-the-treatment-of-inflammation-and-pain-associated-with-ocular-surgery
#2
Rozemarijn S Verhoeven, Andres Garcia, RiLee Robeson, Brian C Gilger, David Culp, Craig Struble, Lee Hamm, Tomas Navratil, Benjamin Yerxa
PURPOSE: Topical corticosteroids are widely used in the treatment of inflammation and pain after ocular surgery, but they possess several shortcomings, including frequent dosing and low patient adherence. We evaluated the efficacy and pharmacokinetics of ENV905 (difluprednate or DFBA) Ophthalmic Implant, a single-dose drug delivery system, compared with 0.05% Durezol. METHODS: PRINT(®) technology was used to fabricate ENV905 implants for either intracameral (IC) or subconjunctival (SCJ) delivery of extended-release DFBA...
June 26, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28650607/self-diffusion-driven-ultrafast-detection-of-ppm-level-nitro-aromatic-pollutants-in-aqueous-media-using-a-hydrophilic-fluorescent-paper-sensor
#3
Wei Lu, Jiawei Zhang, Youju Huang, Patrick Theato, Qing Huang, Tao Chen
Development of fluorescent film probes for toxic nitro aromatic compound pollutants (NACs) such as 2,4,6-trinitrotoluene (TNT) in real water samples implies broad applications in environmental and industrial safety control. Despite many recent advances, there are still some difficult challenges facing this area, e.g., the restricted sensitivity and long response time caused by hindered and slow diffusion of aqueous NACs samples inside a dense, solid film. Hence, we report herein a robust fluorescent paper sensor with improved sensing abilities, which is prepared by absorbing hydrophilic pyrene-functionalized polymer uniformly into cellulose-based filter papers...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28650131/accommodating-intraocular-lenses
#4
Jay S Pepose, Joshua S Burke, Mujtaba A Qazi
With an explosive increase in the worldwide prevalence of presbyopia, development of an accommodating intraocular lens with expansive accommodative amplitude remains the holy grail in lens-based refractive surgery. A dynamic change in the dioptric power of the eye can be accomplished by various strategies alone or in combination, including changes in the position, shape, or refractive index of a single- or dual- optic intraocular lens (IOL). This article reviews the cumulative advances in these various lens designs, along with clinical outcomes and complications of those that have been implanted...
June 26, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28649609/insomnia-and-somnolence-in-idiopathic-rbd-a-prospective-cohort-study
#5
Ronald B Postuma, Jean-François Gagnon, Amelie Pelletier, Jacques Y Montplaisir
Although some sleep disorders are markers of prodromal Parkinson's disease and dementia with Lewy bodies, it is unclear whether insomnia and somnolence can predict disease. We assessed a large cohort of patients with idiopathic rapid eye movement sleep behavior disorder and age/sex matched controls, comparing the Epworth sleepiness scale, the Insomnia Severity Index, the Pittsburgh Sleep Quality Index, and polysomnographic variables. In those with repeated scales, we assessed change over time. Finally, we assessed whether sleep abnormalities predicted defined neurodegenerative disease...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28649596/phenoconversion-from-probable-rapid-eye-movement-sleep-behavior-disorder-to-mild-cognitive-impairment-to-dementia-in-a-population-based-sample
#6
Youngsin Jung, Brendon P Boot, Michelle M Mielke, Tanis J Ferman, Yonas E Geda, Eric McDade, Teresa J H Christianson, David S Knopman, Erik K St Louis, Michael H Silber, Ronald C Petersen, Bradley F Boeve
INTRODUCTION: Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal Olmsted County, Minnesota, residents, aged 70 to 89 years with probable RBD. Here, we examine their progression to dementia and other neurodegenerative phenotypes. METHODS: Fifteen participants with RBD who were diagnosed with either MCI or PD were longitudinally followed, and their subsequent clinical courses were reviewed...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28649427/global-rise-of-potential-health-hazards-caused-by-blue-light-induced-circadian-disruption-in-modern-aging-societies
#7
REVIEW
Megumi Hatori, Claude Gronfier, Russell N Van Gelder, Paul S Bernstein, Josep Carreras, Satchidananda Panda, Frederick Marks, David Sliney, Charles E Hunt, Tsuyoshi Hirota, Toshiharu Furukawa, Kazuo Tsubota
Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28649419/identification-of-transcription-factors-that-promote-the-differentiation-of-human-pluripotent-stem-cells-into-lacrimal-gland-epithelium-like-cells
#8
Masatoshi Hirayama, Shigeru B H Ko, Tetsuya Kawakita, Tomohiko Akiyama, Sravan K Goparaju, Atsumi Soma, Yuhki Nakatake, Miki Sakota, Nana Chikazawa-Nohtomi, Shigeto Shimmura, Kazuo Tsubota, Minoru S H Ko
Dry eye disease is the most prevalent pathological condition in aging eyes. One potential therapeutic strategy is the transplantation of lacrimal glands, generated in vitro from pluripotent stem cells such as human embryonic stem cells, into patients. One of the preceding requirements is a method to differentiate human embryonic stem cells into lacrimal gland epithelium cells. As the first step for this approach, this study aims to identify a set of transcription factors whose overexpression can promote the differentiation of human embryonic stem cells into lacrimal gland epithelium-like cells...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28649215/does-watching-a-play-about-the-teenage-brain-affect-attitudes-toward-young-offenders
#9
Robert Blakey
Neuroscience is increasingly used to infer the cognitive capacities of offenders from the activity and volume of different brain regions, with the resultant findings receiving great interest in the public eye. This field experiment tested the effects of public engagement in neuroscience on attitudes toward offenders. Brainstorm is a play about teenage brain development. Either before or after watching this play, 728 participants responded to four questions about the age of criminal responsibility, and the moral responsibility and dangerousness of a hypothetical young or adult offender...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28649148/origins-and-genetic-diversity-of-introduced-populations-of-the-puerto-rican-red-eyed-coqu%C3%A3-eleutherodactylus-antillensis-in-saint-croix-u-s-virgin-islands-and-panam%C3%A3
#10
Brittany S Barker, Javier A Rodríguez-Robles
The Red-eyed Coquí, Eleutherodactylus antillensis, is a terrestrial frog endemic to the Puerto Rican Bank (Puerto Rico and numerous islands and cays off its eastern coast), in the eastern Caribbean Sea. The species was likely introduced in Saint Croix, an island c. 100 km southeast of Puerto Rico, in the late 1930s, and in Panamá City, Panamá, in the late 1950s or early 1960s, but the source(s) of these introductions are unknown. We analyzed sequence data from one mtDNA locus and four nuDNA introns to infer the origin(s) of the Saint Croix and Panamá City populations and quantify their genetic diversity...
July 2017: Copeia
https://www.readbyqxmd.com/read/28648963/the-association-between-diabetes-level-of-glycaemic-control-and-eye-infection-cohort-database-study
#11
Abdus Samad Ansari, Simon de Lusignan, William Hinton, Neil Munro, Andrew McGovern
AIM: To examine whether diabetes and the degree of glycaemic control is associated with an increased risk of acute eye infection, and prescribing of ocular antimicrobial agents. DESIGN AND SETTING: A retrospective cohort study was carried out using the Royal College of General Practitioners Research and Surveillance Centre database (RCGP RSC), a large primary care database in the United Kingdom. We compared ocular infection rates in people aged ≥15 years without diabetes to those with diabetes, both type 1 and type 2...
June 22, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28648914/psychometrics-of-social-cognitive-measures-for-psychosis-treatment-research
#12
Charlie A Davidson, Rebecca Lesser, Lori T Parente, Joanna M Fiszdon
Social cognition represents an important treatment target, closely linked to everyday social function. While a number of social cognitive interventions have recently been developed, measures used to evaluate these treatments are only beginning to receive psychometric scrutiny. Study goals were to replicate recently-published psychometrics for several social cognitive measures, and to provide information for additional social cognitive measures not included in recent reports. Forty-eight outpatients with psychotic-spectrum disorders completed measures of emotion perception, theory of mind, and attributional bias on two occasions, one month apart...
June 22, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28648816/how-light-affects-the-life-of-botrytis
#13
REVIEW
Julia Schumacher
Fungi, like other organisms, actively sense the environmental light conditions in order to drive adaptive responses, including protective mechanisms against the light-associated stresses, and to regulate development. Ecological niches are characterized by different light regimes, for instance light is absent underground, and light spectra from the sunlight are changed underwater or under the canopy of foliage due to the absorption of distinct wavelengths by bacterial, algal and plant pigments. Considering the fact that fungi have evolved to adapt to their habitats, the complexities of their 'visual' systems may vary significantly...
June 22, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/28648727/detection-of-okadaic-acid-oa-using-elisa-and-colloidal-gold-immunoassay-based-on-monoclonal-antibody
#14
Rongzhi Wang, Linmao Zeng, Hang Yang, Yanfang Zhong, Juncheng Wang, Sumei Ling, Abdullah Farhan Saeed, Jun Yuan, Shihua Wang
Okadaic Acid (OA), a small seafood-borne toxin secreted by Dinophysis and Prorocentrum dinoflagellates, is generally distributed in various species of shellfish and has caused diarrhetic shellfish poisoning (DSP). In view of OA toxin threat to humans and animals, it is essential to develop a rapid, accurate and sensitive method for the detection and quantification of OA in real samples. In this study, a monoclonal antibody named 10E8 was screened by cells fusion of Sp2/0 with spleen cells isolated from immunized mouse, and the isotype of McAb 10E8 was belonged to IgG1...
June 16, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28648371/impacts-of-tannery-effluent-on-development-and-morphological-characters-in-a-neotropical-tadpole
#15
Mateus Flores Montalvão, André Luis da Silva Castro, Aline Sueli de Lima Rodrigues, Bruna de Oliveira Mendes, Guilherme Malafaia
Previous studies have shown the contamination of rivers and streams caused by tannery effluents (TE). However, the effects of TE on amphibians are still unknown. Thus, we evaluated whether the TE, even at low concentrations (0.2%), could cause asymmetric development (inferred through the fluctuating asymmetry indices (FA)) and changes in morphological characteristics of Physalaemus cuvieri larvae. Accordingly, the tadpoles were distributed in groups non-exposed (n=160) and exposed (n=160) to this TE, for 15days...
June 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28648359/evidence-for-the-efficacy-of-melatonin-in-the-treatment-of-primary-adult-sleep-disorders
#16
REVIEW
Fiona Auld, Emily L Maschauer, Ian Morrison, Debra J Skene, Renata L Riha
Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies. The aim of this meta-analysis was to assess the evidence base for the therapeutic effects of exogenous melatonin in treating primary sleep disorders. An electronic literature review search of MEDLINE (1950-present) Embase (1980- present), PsycINFO (1987- present), and Scopus (1990- present), along with a hand-searching of key journals was performed in July 2013 and then again in May 2015...
July 20, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28647127/infrared-light-detection-by-the-haller-s-organ-of-adult-american-dog-ticks-dermacentor-variabilis-ixodida-ixodidae
#17
Robert D Mitchell, Jiwei Zhu, Ann L Carr, Anirudh Dhammi, Grayson Cave, Daniel E Sonenshine, R Michael Roe
The Haller's organ (HO), unique to ticks and mites, is found only on the first tarsus of the front pair of legs. The organ has an unusual morphology consisting of an anterior pit (AP) with protruding sensilla and a posterior capsule (Cp). The current thinking is that the HO's main function is chemosensation analogous to the insect antennae, but the functionality of its atypical structure (exclusive to the Acari) is unexplained. We provide the first evidence that the HO allows the American dog tick, Dermacentor variabilis, to respond to infrared (IR) light...
June 13, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28646862/a-clinical-utility-assessment-of-the-automatic-measurement-method-of-the-quality-of-meibomian-glands
#18
Robert Koprowski, Lei Tian, Paweł Olczyk
BACKGROUND: Meibomian gland dysfunction (MGD) is one of the most common diseases observed in clinics and is the leading cause of evaporative dry eye. Today, diagnostics of MGD is not fully automatic yet and is based on a qualitative assessment made by an ophthalmologist. Therefore, an automatic analysis method was developed to assess MGD quantiatively. MATERIALS: The analysis made use of 228 images of 57 patients recorded by OCULUS Keratograph(®) 5 M with a resolution of 1024 × 1360 pixels concern 30 eyes of healthy individuals (14 women and 16 men) and 27 eyes of sick patients (10 women and 17 men)...
June 24, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28646719/dna-aptamer-based-colorimetric-detection-platform-for-salmonella-enteritidis
#19
Ceren Bayraç, Füsun Eyidoğan, Hüseyin Avni Öktem
Food safety is a major issue to protect public health and a key challenge is to find detection methods for identification of hazards in food. Food borne infections affects millions of people each year and among pathogens, Salmonella Enteritidis is most widely found bacteria causing food borne diseases. Therefore, simple, rapid, and specific detection methods are needed for food safety. In this study, we demonstrated the selection of DNA aptamers with high affinity and specificity against S. Enteritidis via Cell Systematic Evolution of Ligands by Exponential Enrichment (Cell-SELEX) and development of sandwich type aptamer-based colorimetric platforms for its detection...
June 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28646619/early-insights-into-zika-s-microcephaly-physiopathology-from-the-epicentre-of-the-outbreak-teratogenic-apoptosis-on-the-central-nervous-system
#20
Patricia Jungmann, Pedro Pires, Edward Araujo
Foetal infection by the Zika virus has been implicated in the exceptional rise in the number of mycrocephalic newborns recorded by the end of 2015 in Brazil. The mechanism by which this teratogenic effect is produced in the developing brain has not been entirely established. Very early in the outbreak, we addressed this question by evaluating available initial data from a gestational and post-natal clinical investigation in the Brazilian state of Pernambuco. The present study was undertaken to test the hypothesis that the subtractive dysmorphic brain malformations observed in Zika's microcephaly are primarily due to the massive induction of apoptosis of neuroprogenitor cells...
June 24, 2017: Acta Obstetricia et Gynecologica Scandinavica
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