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https://www.readbyqxmd.com/read/28934694/development-and-implementation-of-a-pass-fail-field-friendly-method-for-detecting-sildenafil-in-suspect-pharmaceutical-tablets-using-a-handheld-raman-spectrometer-and-silver-colloids
#1
Adam Lanzarotta, Lisa Lorenz, JaCinta S Batson, Cheryl Flurer
A simple, fast, sensitive and effective pass/fail field-friendly method has been developed for detecting sildenafil in suspect Viagra and unapproved tablets using handheld Raman spectrometers and silver colloids. The method involves dissolving a portion of a tablet in water followed by filtration and addition of silver colloids, resulting in a solution that can be measured directly through a glass vial. Over one hundred counterfeit Viagra and unapproved tablets were examined on three different devices during the method development phase of the study...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28934586/improving-student-outcomes-in-higher-education-the-science-of-targeted-intervention
#2
Judith M Harackiewicz, Stacy J Priniski
Many theoretically based interventions have been developed over the past two decades to improve educational outcomes in higher education. Based in social-psychological and motivation theories, well-crafted interventions have proven remarkably effective because they target specific educational problems and the processes that underlie them. In this review, we evaluate the current state of the literature on targeted interventions in higher education with an eye to emerging theoretical and conceptual questions about intervention science...
September 20, 2017: Annual Review of Psychology
https://www.readbyqxmd.com/read/28933276/cyclophosphamide-and-or-anthracyclines-induced-epiphora-in-breast-cancer-patients-a-rare-side-effect
#3
Ruchika Kalra, Bhavesh Chavada, Nishant R Madhani, Bhargav Purohit, C B Tripathi
Two female breast cancer patients developed epiphora after administration of Cyclophosphamide and/or anthracyclines based 2-day chemotherapy regimen. The ophthalmologist was consulted and no apparent cause was found. Both patients was managed by ciprofloxacin eye drops. Chemotherapy-induced ocular complications are not uncommon, but under-reported. Although epiphora is a mild reaction if severe can interfere with daily activities. Patients receiving anticancer drugs should have a thorough ocular evaluation, in order to prevent, early diagnose and efficiently treat established ocular complications of the chemotherapy treatment...
September 19, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28932584/two-cases-of-pulmonary-cysticercosis-manifesting-as-pleural-effusion-case-report-and-literature-review
#4
Youfei Chen, Pingli Wang, Liren Ding
Cysticercosis is an important public health problem in developing countries. The major involvement sites are the central nervous system and the eyes, although striated muscles and subcutaneous tissues are frequently involved in the disseminated form of disease. Pulmonary involvement in cysticercosis is very rare and ill-defined nodular shadows distributed throughout the lung is the usual radiological presentation. Only one case of cysticercosis presenting as lung cavity with pleural effusion has been reported so far in literature...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932335/cataract-surgery-in-patients-with-keratoconus-pearls-and-pitfalls
#5
F Aiello, Q J Nasser, C Nucci, R I Angunawela, Z Gatzioufas, V Maurino
BACKGROUND: Keratoconus (KC) is a common ectatic disorder resulting in progressive corneal thinning and irregular astigmatism. It has been observed that patients affected by KC are more likely to develop lens opacities earlier compared to non-keratoconic patients. OBJECTIVE: Intraocular lens (IOL) selection and refractive outcome prediction are among a number of factors that can make cataract surgery in keratoconic patients challenging. Accurate biometry is often difficult to obtain due to unreliable K measurements and lack of dedicated biometric formulae...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28931988/the-relationship-between-ground-reaction-force-in-sit-to-stand-movement-and-lower-extremity-function-in-community-dwelling-japanese-older-adults-using-long-term-care-insurance-services
#6
Shaoshuai Shen, Takumi Abe, Taishi Tsuji, Keisuke Fujii, Jingyu Ma, Tomohiro Okura
[Purpose] The purpose of this study was to investigate which of the four chair-rising methods has low-load and the highest success rate, and whether the GRF parameters in that method are useful for measuring lower extremity function among physically frail Japanese older adults. [Subjects and Methods] Fifty-two individuals participated in this study. The participants voluntarily attempted four types of Sit-to-stand test (one variation without and three variations with the use of their arms). The following parameters were measured: peak reaction force (F/w), two force development rate parameters (RFD1...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28931389/semi-automated-quantification-of-hard-exudates-in-colour-fundus-photographs-diagnosed-with-diabetic-retinopathy
#7
Abhilash Goud Marupally, Kiran Kumar Vupparaboina, Hari Kumar Peguda, Ashutosh Richhariya, Soumya Jana, Jay Chhablani
BACKGROUND: Hard exudates (HEs) are the classical sign of diabetic retinopathy (DR) which is one of the leading causes of blindness, especially in developing countries. Accordingly, disease screening involves examining HEs qualitatively using fundus camera. However, for monitoring the treatment response, quantification of HEs becomes crucial and hence clinicians now seek to measure the area of HEs in the digital colour fundus (CF) photographs. Against this backdrop, we proposed an algorithm to quantify HEs using CF images and compare with previously reported technique using ImageJ...
September 20, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28931299/-steroid-induced-glaucoma-as-a-complication-of-atopic-eczema-local-treatment
#8
T Řeháková, A Stepanov, N Jirásková
The authors present case reports of two young women, who visited the outpatient Department of Ophthalmology clinic, University Hospital in Hradec Králové with lacklustre subjective eye complaints lasting over few weeks. It the beginning high values of intraocular pressure in both eyes and severe glaucomatous damage of the optic nerve head were find out, which was confirm using perimetry and OCT (optical coherence tomography). The anamnesis has shown that both patients have been treated for atopic eczema since their childhood...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28930702/gcamp-expression-in-retinal-ganglion-cells-characterized-using-a-low-cost-fundus-imaging-system
#9
Yao-Chuan Chang, Steven T Walston, Robert H Chow, James D Weiland
OBJECTIVE: Virus-transduced, intracellular-calcium indicators are effective reporters of neural activity, offering the advantage of cell-specific labeling. Due to the existence of an optimal time window for the expression of calcium indicators, a suitable tool for tracking GECI expression in vivo following transduction is highly desirable. APPROACH: We developed a noninvasive imaging approach based on a custom-modified, low-cost fundus viewing system that allowed us to monitor and characterize in vivo bright-field and fluorescence images of the mouse retina...
October 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28930558/dna-replication-machinery-contributes-to-development-of-eye-in-drosophila
#10
Hidetsugu Kohzaki, Yota Murakami
Chromosomal DNA replication machinery is essential for growth of all cells in all organs in multicellular organisms. Its knockdown in several tissues of Drosophila led to rough eye phenotype and the loss of bristles in the eye. These results show that the DNA replication machinery contributes to the body development independent of growth.
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930545/classification-of-retinal-diseases-based-on-oct-images
#11
Nabila Eladawi, Mohammed M Elmogy, Mohammed Ghazal, Omar Helmy, Ahmed Aboelfetouh, Alaa Riad, Shlomit Schaal, Ayman El-Baz
Optical Coherence Topography (OCT) is an emerging biomedical imaging technology that offers non-invasive real-time, high-resolution imaging of highly scattering tissues. It is widely used in ophthalmology to perform diagnostic imaging on the structure of the anterior eye and the retina. Clinical studies are carried out to assess the application of OCT for some retinal diseases. OCT can provide means for early detection for various types of diseases because morphological changes often occur before the physical symptoms of these diseases...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929784/investigating-children-s-perception-of-nurses-through-their-drawings
#12
Nazan Çakirer Çalbayram, Sebahat Altundağ, Bahise Aydin
Hospitalized children can have various fantasies about hospital, health staff, and related tools and equipment. They need to develop new coping strategies for compliance with hospitalization.This study aimed to investigate the perception of nurses by children with acute and chronic illness through their drawings. The study was carried out using a descriptive research model. "Nurses through the eyes of sick children data collection form" was used in data collection procedure. The instruction "draw a picture of a nurse, please" was used to get the children to draw a picture...
September 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28929348/-comparative-analysis-of-light-sensitivity-depth-and-motion-perception-in-animals-and-humans
#13
REVIEW
F Schaeffel
BACKGROUND: This study examined how humans perform regarding light sensitivity, depth perception and motion vision in comparison to various animals. OBJECTIVE: The parameters that limit the performance of the visual system for these different functions were examined. METHODS: This study was based on literature studies (search in PubMed) and own results. RESULTS: Light sensitivity is limited by the brightness of the retinal image, which in turn is determined by the f‑number of the eye...
September 19, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28929046/application-of-three-dimensional-printing-for-colon-targeted-drug-delivery-systems
#14
REVIEW
Nitin B Charbe, Paul A McCarron, Majella E Lane, Murtaza M Tambuwala
Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide have been interested in colon drug delivery for several decades, not only for the delivery of the drugs for the treatment of colonic diseases such as ulcerative colitis and colon cancer but also for delivery of therapeutic proteins and peptides for systemic absorption...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28927928/discerning-the-composition-of-penetratin-for-safe-penetration-from-cornea-to-retina
#15
Kuan Jiang, Xin Gao, Qing Shen, Changyou Zhan, Yanyu Zhang, Cao Xie, Gang Wei, Weiyue Lu
Delivery of biomacromolecules into the eye is greatly hindered by several protective barriers. The cell-penetrating peptide, penetratin, has been found to be an effective absorption enhancer for noninvasive intraocular gene delivery. To discern the composition of penetratin for safe penetration from cornea to retina, we designed a series of penetratin derivatives by varying the hydrophobicity and evaluated their potency for retina-targeted delivery. The hydrophilic amino acids of penetratin, excluding the conserved basic amino acid residues, were respectively replaced with tryptophan...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28927532/beyond-mouse-cancer-models-three-dimensional-human-relevant-in-vitro-and-non-mammalian-in-vivo-models-for-photodynamic-therapy
#16
REVIEW
Malgorzata Kucinska, Marek Murias, Patrycja Nowak-Sliwinska
The proper design of experiments is a critical step for each study in order to obtain reproducible and reliable data. Taking into account constant competitiveness in the quickly developing biomedical sciences and the availability of sophisticated techniques, the choice and establishment of an experimental model system are essential for a successful research project. Currently, various sophisticated in vitro and in vivo models are being designed and developed in order to replace the use of mammalian models to investigate the mechanisms of action, activity and properties of novel compounds or treatment modalities...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28927495/preventing-myopia
#17
Wolf A Lagrèze, Frank Schaeffel
BACKGROUND: Nearsightedness (myopia) has become more common around the world recently, mainly because of changes in visual, educational, and recreational behavior. The question arises how the risk of myopia and its progression can be reduced. This would lessen the prevalence and severity of myopia and also lower the risk of secondary diseases that impair visual acuity. METHODS: The PubMed/Medline database was selectively searched for pertinent literature. RESULTS: The risk of myopia is lowered by exposure to daylight and increased by activities performed at short visual distances (close-up work)...
September 4, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28926950/development-of-a-textile-nanocomposite-as-naked-eye-indicator-of-the-exposition-to-strong-acids
#18
Isabel Pallás, Maria D Marcos, Ramón Martínez-Máñez, Jose V Ros-Lis
Chemical burns, mainly produced by acids, are a topic of concern. A new sensing material for the detection of strong acids able to be incorporated into textiles has been developed. The material is prepared by the covalent attachment of 2,2',4,4',4″-pentamethoxy triphenyl methanol to a mesoporous material which further is included in a nitro resin to obtain a colourless composite. The response of this composite to diverse acid solutions was tested showing the appearance of an intense purple colour (with a colour difference higher than 160) that can be monitored by the naked eye or could be easily digitised to feed an instrumental sensor...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28926880/-emphasis-on-standardization-and-refinement-in-the-diagnosis-and-treatment-of-dry-eye
#19
Z G Liu
Dry eye is the second most common ocular disease. In China, the incidence rate of dry eye has reached 21% to 30%, and dry eye patients have accounted for more than 30% of the total ophthalmology outpatients. Dry eye has become a common health problem that affects the working efficiency and life quality of Chinese people. Over the past decade, due to the rapid development of diagnostic equipments and new treatments for dry eye, dry eye has become one of the areas with greatest concerns in ophthalmology, and many eye institutions have set up their dry eye clinics...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926640/aire-deficient-mice-provide-a-model-of-corneal-and-lacrimal-gland-neuropathy-in-sj%C3%A3-gren-s-syndrome
#20
Feeling Y Chen, Albert Lee, Shaokui Ge, Sara Nathan, Sarah M Knox, Nancy A McNamara
Sjögren's syndrome (SS) is a chronic, autoimmune exocrinopathy that leads to severe dryness of the mouth and eyes. Exocrine function is highly regulated by neuronal mechanisms but little is known about the link between chronic inflammation, innervation and altered exocrine function in the diseased eyes and exocrine glands of SS patients. To gain a better understanding of neuronal regulation in the immunopathogenesis of autoimmune exocrinopathy, we profiled a mouse model of spontaneous, autoimmune exocrinopathy that possess key characteristics of peripheral neuropathy experienced by SS patients...
2017: PloS One
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