keyword
MENU ▼
Read by QxMD icon Read
search

Eye development

keyword
https://www.readbyqxmd.com/read/29342438/vitreoretinal-complications-and-outcomes-in-92-eyes-undergoing-surgery-for-modified-osteo-odonto-keratoprosthesis-a-10-year-review
#1
Pukhraj Rishi, Ekta Rishi, Vishvesh Agarwal, Sridevi Nair, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal
PURPOSE: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery. DESIGN: Retrospective case series. PARTICIPANTS: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. METHODS: Medical records were reviewed for relevant medical history, best-corrected visual acuity (BCVA), slit-lamp examination, ultrasound scan, oral examination findings, and VR complications...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29342191/changes-in-balance-and-joint-position-sense-during-a-12-day-high-altitude-trek-the-british-services-dhaulagiri-medical-research-expedition
#2
Sarah B Clarke, Kevin Deighton, Caroline Newman, Gareth Nicholson, Liam Gallagher, Christopher J Boos, Adrian Mellor, David R Woods, John P O'Hara
Postural control and joint position sense are essential for safely undertaking leisure and professional activities, particularly at high altitude. We tested whether exposure to a 12-day trek with a gradual ascent to high altitude impairs postural control and joint position sense. This was a repeated measures observational study of 12 military service personnel (28±4 years). Postural control (sway velocity measured by a portable force platform) during standing balance, a Sharpened Romberg Test and knee joint position sense were measured, in England (113m elevation) and at 3 research camps (3619m, 4600m and 5140m) on a 12-day high altitude trek in the Dhaulagiri region of Nepal...
2018: PloS One
https://www.readbyqxmd.com/read/29342127/enhancement-in-corneal-permeability-of-dissolved-carteolol-by-its-combination-with-magnesium-hydroxide-nanoparticles
#3
Noriaki Nagai, Sakie Yamaoka, Yuya Fukuoka, Miyu Ishii, Hiroko Otake, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura
We prepared magnesium hydroxide (MH) nanoparticles, and investigated their effect when combined with dissolved carteolol on the bioavailability and intraocular pressure (IOP)-reducing effect of carteolol. The carteolol was solved in saline containing additives (0.5% methylcellulose, 0.001% benzalkonium chloride, 0.5% mannitol; CRT-solution). MH nanoparticles were prepared by a bead mill method with additives. Then carteolol/MH microparticle and carteolol/MH nanoparticle fixed combinations (mCMFC and nCMFC) were prepared by mixing the CRT-solution and MH particles...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341445/automated-detection-of-preserved-photoreceptor-on-optical-coherence-tomography-in-choroideremia-based-on-machine-learning
#4
Zhuo Wang, Acner Camino, Ahmed M Hagag, Jie Wang, Richard G Weleber, Paul Yang, Mark E Pennesi, David Huang, Dengwang Li, Yali Jia
Optical coherence tomography (OCT) can demonstrate early deterioration of the photoreceptor integrity caused by inherited retinal degeneration diseases (IRD). A machine learning method based on random forests was developed to automatically detect continuous areas of preserved ellipsoid zone structure (an easily recognizable part of the photoreceptors on OCT) in sixteen eyes of patients with choroideremia (a type of IRD). Pseudopodial extensions protruding from the preserved ellipsoid zone areas are detected separately by a local active contour routine...
January 17, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29340648/a-novel-strategy-for-quantifying-choriocapillaris-flow-voids-using-swept-source-oct-angiography
#5
Qinqin Zhang, Fang Zheng, Elie H Motulsky, Giovanni Gregori, Zhongdi Chu, Chieh-Li Chen, Chunxia Li, Luis de Sisternes, Mary Durbin, Philip J Rosenfeld, Ruikang K Wang
Purpose: To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). Methods: Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch's membrane (BM) to approximately 20 μm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29340284/optical-imaging-during-toddlerhood-brain-responses-during-naturalistic-social-interactions
#6
Yoko Hakuno, Laura Pirazzoli, Anna Blasi, Mark H Johnson, Sarah Lloyd-Fox
Despite the importance of our ability to interact and communicate with others, the early development of the social brain network remains poorly understood. We examined brain activity in 12- to 14-month-old infants while they were interacting live with an adult in two different naturalistic social scenarios (i.e., reading a picture book versus singing nursery rhymes with gestures), as compared to baseline (i.e., showing infants a toy without eye contact or speech). We used functional near-infrared spectroscopy (fNIRS) recorded over the right temporal lobe of infants to assess the role of the superior temporal sulcus-temporoparietal junction (STS-TPJ) region during naturalistic social interactions...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/29340020/eya2-promotes-lung-cancer-cell-proliferation-by-downregulating-the-expression-of-pten
#7
Zhaoming Li, Ran Qiu, Xia Qiu, Tian Tian
Lung cancer is the leading cause of cancer-related death worldwide. Despite advances have been made in diagnosis and therapeutic strategies, the prognosis of lung cancer is still very poor. Eyes absent transcriptional cofactor EYA2 has been shown to promote lung cancer cell growth, however, the underlying molecular mechanism is still not fully understood. In the present study, we found that EYA2 was up-regulated in lung cancer, and EYA2 led to increased cell proliferation by inhibiting Phosphatase and tensin homologue (PTEN) expression via modulation of miR-93...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339919/effect-of-oral-tranexamic-acid-on-macular-edema-associated-with-retinal-vein-occlusion-or-diabetes
#8
Masayuki Takeyama, Fumio Takeuchi, Masahiko Gosho, Keijiro Sugita, Masahiro Zako, Masayoshi Iwaki, Motohiro Kamei
Purpose: Tranexamic acid (TXA) is a widely used antifibrinolytic agent that can also cause a decrease in vascular permeability. We hypothesized that TXA could improve macular edema (ME) that is caused by an increase in retinal vascular permeability. The aim of this study is to evaluate the efficacy of oral TXA for ME associated with retinal vein occlusion (RVO) or diabetic ME (DME). Patients and methods: Oral TXA (1,500 mg daily for 2 weeks) was administered to patients with persistent ME secondary to RVO (7 eyes) and DME (7 eyes)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29339916/pediatric-cataract-surgery-with-hydrophilic-acrylic-intraocular-lens-implantation-in-nepalese-children
#9
Srijana Adhikari, Ujjowala D Shrestha
Purpose: To assess the outcome of cataract surgery with hydrophilic acrylic intraocular lens (IOL) implantation in children with congenital and developmental cataracts. Method: A retrospective review of medical records of children with congenital or developmental cataracts who underwent cataract surgery with hydrophilic IOL implantation, from January 2011 to December 2014 in a tertiary eye hospital in Nepal. Primary posterior capsulotomy, anterior vitrectomy, and IOL implantation was done in children 8 years or younger, while older children underwent only lens aspiration and IOL implantation...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29339637/corneal-collagen-crosslinking-combined-with-phototherapeutic-keratectomy-and-photorefractive-keratectomy-for-corneal-ectasia-after-laser-in-situ-keratomileusis
#10
Wei Zhu, Yunfei Han, Changxia Cui, Wenwen Xu, Xuan Wang, Xiaoxiao Dou, Linlin Xu, Yanyun Xu, Guoying Mu
PURPOSE: The aim of this study was to analyze the effects of corneal crosslinking (CXL) combined with phototherapeutic keratectomy (PTK) and photorefractive keratectomy (PRK) in halting the progression and improving the visual function of corneal ectasia after laser in situ keratomileusis (LASIK). METHODS: PTK-PRK-CXL was performed on 14 eyes of 14 patients who developed corneal ectasia after LASIK. The visual acuity, spherical refraction and cylinder, corneal topography indices, thinnest corneal thickness (TCT), and endothelial cell count were evaluated at baseline and at 1, 3, 6, and 12 months postoperatively...
January 17, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29339249/semifluorinated-alkane-based-systems-for-enhanced-corneal-penetration-of-poorly-soluble-drugs
#11
Priyanka Agarwal, Dieter Scherer, Bernhard Günther, Ilva D Rupenthal
Semifluorinated alkanes (SFAs) are amphiphilic liquids that can dissolve hydrophobic drugs to form clear solutions. This study evaluated the potential of two SFAs to act as vehicle for topical ocular drug delivery. After confirming ocular safety, an ex vivo corneal penetration model was developed to determine drug distribution and corneal bioavailability. Hydrophobic dye distribution in the different corneal layers was visualised under a confocal microscope. Corneal bioavailability of cyclosporine A (CsA) dissolved in perfluorobutylpentane (F4H5) or perfluorohexyloctane (F6H8) was compared to commercially available CsA ophthalmic emulsions, Restasis® and Ikervis®...
January 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29339120/symmetry-of-peripheral-retinal-nonperfusion-in-diabetic-retinopathy-by-ischemic-index
#12
Ashley M Speilburg, Bruce Teitelbaum, Yi Pang, Shaun Ittiara
PURPOSE: Diabetic retinopathy is the leading cause of blindness among working-age adults in most developed countries. It affects eyes bilaterally and is generally believed to be symmetrical, yet there are few studies evaluating the symmetry of diabetic retinopathy. The purpose of the present study was to evaluate the symmetry of the amount of peripheral retinal ischemia in patients with diabetic retinopathy. METHODS: Ultra-widefield fluorescein angiography images were obtained on both eyes of 54 subjects, mean age 56...
January 12, 2018: Journal of Optometry
https://www.readbyqxmd.com/read/29338772/incidence-risk-factors-and-impact-of-protocolised-care-on-exposure-keratopathy-in-critically-ill-adults-a-two-phase-prospective-cohort-study
#13
Obaid Kousha, Zubaid Kousha, Jonathan Paddle
BACKGROUND: Exposure keratopathy (EK) has a high incidence in critically ill patients. We aimed to determine the rate of EK in patients admitted to our intensive care unit (ICU), identify risk factors for developing EK and ascertain the effectiveness of a protocol to prevent EK. METHODS: We undertook a two-phase prospective cohort single-centre study in a general adult ICU. The first phase of the study was observational. In the second phase of the study an eye care protocol was introduced...
January 16, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29338721/infectious-keratoconjunctivitis-in-semi-domesticated-eurasian-tundra-reindeer-rangifer-tarandus-tarandus-microbiological-study-of-clinically-affected-and-unaffected-animals-with-special-reference-to-cervid-herpesvirus-2
#14
Javier Sánchez Romano, Torill Mørk, Sauli Laaksonen, Erik Ågren, Ingebjørg H Nymo, Marianne Sunde, Morten Tryland
BACKGROUND: Infectious keratoconjunctivitis (IKC) is one of the most common ocular diseases in ruminants worldwide. In addition to keratitis and conjunctivitis, animals with IKC can develop uveitis, corneal ulcer, and in severe cases, blindness. The bacteria Moraxella spp. has been described as the primary causative agent of infectious bovine keratoconjunctivitis (IBK) in cattle (Bos taurus), while Chlamydia spp. and Mycoplasma conjunctivae are considered the main causative agents of IKC in sheep (Ovis aries)...
January 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29338382/mounting-of-biomaterials-for-use-in-ophthalmic-cell-therapies
#15
Damien G Harkin, Siobhan E Dunphy, Audra M A Shadforth, Rebecca A Dawson, Jennifer Walshe, Nadia Zakaria
When used as scaffolds for cell therapies, biomaterials often present basic handling and logistical problems for scientists and surgeons alike. The quest for an appropriate mounting device for biomaterials is therefore a significant and common problem. In this review, we provide a detailed overview of the factors to consider when choosing an appropriate mounting device including those experienced during cell culture, quality assurance, and surgery. By way of example, we draw upon our combined experience in developing epithelial cell therapies for the treatment of eye diseases...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29338133/pimasertib-associated-ophthalmological-adverse-events
#16
Elon H C van Dijk, Wim H J Kruit, Martine J Jager, Gregorius P M Luyten, Johannes R Vingerling, Camiel J F Boon
PURPOSE: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM). METHODS: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29338044/probing-the-changes-in-gene-expression-due-to-%C3%AE-crystallin-mutations-in-mouse-models-of-hereditary-human-cataract
#17
Usha P Andley, Eric Tycksen, Brittney N McGlasson-Naumann, Paul D Hamilton
The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life. The structural destabilization of crystallins by UV exposure, glycation, oxidative stress and mutations in crystallin genes leads to protein aggregation and development of cataracts. Several destabilizing mutations in crystallin genes are linked with human autosomal dominant hereditary cataracts...
2018: PloS One
https://www.readbyqxmd.com/read/29338030/incidence-microbiology-and-outcomes-of-endophthalmitis-after-111-876-pars-plana-vitrectomies-at-a-single-tertiary-eye-care-hospital
#18
Muna Bhende, Rajiv Raman, Mukesh Jain, Pratik K Shah, Tarun Sharma, Lingam Gopal, Pramod S Bhende, Sangeetha Srinivasan, Malathi Jambulingam
PURPOSE: To describe the incidence, risk factors, clinical presentation, causative organisms, and outcomes in patients with endophthalmitis following pars plana vitrectomy (20G and minimally invasive vitrectomy surgery (MIVS). METHODS: Of 111,876 vitrectomies (70,585 20-G 41,291 MIVS) performed, 45 cases developed acute-onset, postoperative endophthalmitis. RESULTS: The rate of culture positive and culture negative endophthalmitis was 0.021% (2...
2018: PloS One
https://www.readbyqxmd.com/read/29337142/express-a-database-of-transcriptome-profiles-encompassing-known-and-novel-transcripts-across-multiple-development-stages-in-eye-tissues
#19
Gungor Budak, Soma Dash, Rajneesh Srivastava, Salil A Lachke, Sarath Chandra Janga
Advances in sequencing have facilitated nucleotide-resolution genome-wide transcriptomic profiles across multiple mouse eye tissues. However, these RNA sequencing (RNA-seq) based eye developmental transcriptomes are not organized for easy public access, making any further analysis challenging. Here, we present a new database "Express" (http://www.iupui.edu/∼sysbio/express/) that unifies various mouse lens and retina RNA-seq data and provides user-friendly visualization of the transcriptome to facilitate gene discovery in the eye...
January 11, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29336696/controlled-adverse-environment-chambers-in-dry-eye-research
#20
Margarita Calonge, Marc Labetoulle, Elisabeth M Messmer, Sunil Shah, Yonca A Akova, Kostas G Boboridis, Jesús Merayo-Lloves, Pasquale Aragona, José Benítez-Del-Castillo, Gerd Geerling, Maurizio Rolando, Christophe Baudouin
Dry eye disease (DED) is a common condition with signs and symptoms that vary depending on a wide range of environmental factors to which people are exposed in their daily lives. Factors such as variable temperature, airflow velocity, relative humidity, seasonality, and pollutants can alter the rate of tear film evaporation, improving or exacerbating symptoms of DED. Results from currently available clinical tests do not always correlate well with patient-reported symptoms, and the continually changing environment and variability in DED symptoms present challenges for the design and conduct of clinical trials...
January 16, 2018: Current Eye Research
keyword
keyword
42145
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"