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https://www.readbyqxmd.com/read/29166577/cell-cycle-related-kinase-regulates-mammalian-eye-development-through-positive-and-negative-regulation-of-the-hedgehog-pathway
#1
Floria I Lupu, Jacob B Burnett, Jonathan T Eggenschwiler
Cell cycle-related kinase (CCRK) is a conserved regulator of ciliogenesis whose loss in mice leads to a wide range of developmental defects, including exencephaly, preaxial polydactyly, skeletal abnormalities, and microphthalmia. Here, we investigate the role of CCRK in mouse eye development. Ccrk mutants show dramatic patterning defects, with an expansion of the optic stalk domain into the optic cup, as well as an expansion of the retinal pigment epithelium (RPE) into neural retina (NR) territory. In addition, Ccrk mutants display a shortened optic stalk...
November 19, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29160537/relationship-between-anterior-segment-and-optic-nerve-head-parameters-in-healthy-subjects
#2
Ali Bulent Cankaya, Serdar Ozates
PURPOSE: To determine the relationship between anterior segment and optic nerve head (ONH) parameters. METHODS: Two hundred healthy subjects were enrolled in this study. The par-ticipants underwent measurement of anterior segment parameters with a Pentacam Scheimpflug system and imaging of the optic disc with confocal scanning laser ophthalmoscopy. Pearson's correlation coefficient was calculated to assess the associations between ONH and anterior segment parameters...
September 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29145429/heritability-of-the-morphology-of-optic-nerve-head-and-surrounding-structures-the-healthy-twin-study
#3
Jong Chul Han, Hyeonyoung Ko, Seung Hoon Kim, Taekkwan Rhee, Seung Wan Nam, Sungsoon Hwang, Ga-In Lee, Joohon Sung, Yun-Mi Song, Changwon Kee
BACKGROUND: Optic nerve head (ONH) and surrounding structures such as β-zone peripapillary atrophy (PPA) are important structures in glaucomatous pathogenesis. Thus, for understanding genetic components in glaucoma pathogenesis, it is necessary to evaluate the heritability of ONH and surrounding structures. The present study investigated the genetic influences on ONH and surrounding structures such as β-zone PPA and retinal vessels. METHODS: A total of 1,205 adult twins and their family members (362 monozygotic (MZ) twin subjects (181 pairs), 64 dizygotic (DZ) twin subjects (32 pairs), and 779 singletons from 261 families), were part of the Korean Healthy Twin Study...
2017: PloS One
https://www.readbyqxmd.com/read/29144417/fast-low-cost-and-non-destructive-physico-chemical-analysis-of-virgin-olive-oils-using-near-infrared-reflectance-spectroscopy
#4
Ana Garrido-Varo, María-Teresa Sánchez, María-José De la Haba, Irina Torres, Dolores Pérez-Marín
Near-Infrared (NIR) Spectroscopy was used for the non-destructive assessment of physico-chemical quality parameters in olive oil. At the same time, the influence of the sample presentation mode (spinning versus static cup) was evaluated using two spectrophotometers with similar optical characteristics. A total of 478 olive oil samples were used to develop calibration models, testing various spectral signal pre-treatments. The models obtained by applying MPLS regression to spectroscopic data yielded promising results for olive oil quality measurements, particularly for acidity, the peroxide index and alkyl and ethyl ester content...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29120259/signal-alteration-in-the-optic-nerve-head-on-3d-t2-weighted-mri-a-potential-neuroimaging-sign-of-glaucomatous-optic-neuropathy
#5
Jong Yeon Lee, Hyo Jeong Kwon, Su Jin Park, Chungkwon Yoo, Yong Yeon Kim, Eung Yeop Kim
PURPOSE: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm(3)) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively...
November 9, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29118619/revision-of-the-family-carabodidae-acari-oribatida-xii-yoshiobodes-camerunensis-sp-n-and-rugocepheus-costaricensis-sp-n
#6
Nestor Fernandez, Pieter Theron, Sergio Leiva, Louwrens Tiedt
Yoshiobodes camerunensissp. n., collected in Cameroon, is the first species of this genus reported from the Afrotropical region. Diagnostic characters include lamellae terminating in a bridge and not in lamellar tips; cup-shaped bothridia, bothridial ring present; rostral setae cochleariform, smooth; lamellar setae slightly lanceolate, barbate; fifteen pairs of notogastral setae; c3 lanceolate, rounded end, with longitudinal shallow grooves; other notogastral setae curved lanceolate-cochleariform. Rugocepheus costaricensissp...
2017: ZooKeys
https://www.readbyqxmd.com/read/29109895/are-all-retinal-nerve-fiber-layer-defects-on-optic-coherence-tomography-glaucomatous
#7
Sirel Gür Güngör, Akman Ahmet
Objectives: In this study, we investigated the patients who were referred to our clinic with a prediagnosis of glaucoma based on retinal nerve fiber layer (RNFL) defects on optic coherence tomography (OCT) but were determined to have nonglaucomatous RNLF defects upon detailed examination. Materials and Methods: The ophthalmic examination notes, OCT images, Heidelberg retinal tomography (HRT) II and fundus photographs of 357 patients were retrospectively evaluated...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29108792/comparison-of-the-primary-stability-of-a-porous-coated-acetabular-revision-cup-with-a-standard-cup
#8
Nicholas A Beckmann, Sebastian Jaeger, Maciej B Janoszka, Matthias C Klotz, Thomas Bruckner, Rudi G Bitsch
BACKGROUND: The number of revision hip arthroplasty procedures has been increasing substantially, with the acetabular component requiring component revision in over half of the cases. New porous implant designs attempt to improve outcomes due to improved osseointegration; however, sufficient primary stability is paramount for good osseointegration. METHODS: We compared 2 revision cups of the same geometry, yet different surface properties in an in vitro scenario: a porous titanium surface and a conventional sintered-bead titanium surface...
September 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29076672/determination-of-association-of-pigmentary-glaucoma-with-pigment-dispersion-syndrome
#9
Imtiaz Ali Shah, Shujaat Ali Shah, Partab Rai Nagdev, Safdar Ali Abbasi, Naeem Ali Abbasi, Safdar Akhtar Katpar
BACKGROUND: Pigment Dispersion Syndrome (PDS) is an autosomal dominant disorder of white males between 20 to 40 years of age characterized by deposition of pigment on the lens, zonules of lens, trabecular meshwork and corneal endothelium (Krukenberg's spindle) in addition to radial, spoke like transillumination defects in the mid peripheral iris. This study was conducted to determine the frequency of occurrence of Pigmentary Glaucoma in patients with Pigment Dispersion Syndrome (PDS)...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29044060/interocular-symmetry-of-retinal-nerve-fiber-layer-and-optic-nerve-head-parameters-measured-by-cirrus-high-definition-optical-coherence-tomography-in-a-normal-pediatric-population
#10
Neelam Pawar, Devendra Maheshwari, Meenakshi Ravindran, Renagappa Ramakrishnan
PURPOSE: To determine interocular differences in the retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters in a pediatric population using Cirrus high-definition optical coherence tomography (HD-OCT). METHODS: Seventy normal Indian children aged 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the RNFL and ONH by Cirrus HD-OCT...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28984709/measurement-of-optic-disc-cup-surface-depth-using-cirrus-hd-oct
#11
Young Kook Kim, Ahnul Ha, Won June Lee, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To introduce the measurement method of optic disc cup surface depth using spectral-domain optical coherence tomography (SD-OCT) and then evaluate the rates of cup surface depression at three different stages of glaucoma. METHODS: We retrospectively identified 52 eyes with preperimetric glaucoma, 56 with mild-or-moderate glaucoma and 50 with severe glaucoma and followed them for at least 48 months. Eyes were imaged using SD-OCT (Cirrus™ HD-OCT) at 12-month intervals...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28982124/prevalence-of-retinal-nerve-fiber-layer-defects-the-korea-national-health-and-nutrition-examination-survey-2008-2012
#12
Kyeong Ik Na, Jin Wook Jeoung, Won June Lee, Young Kook Kim, Chan Yun Kim, Ki Ho Park
PURPOSE: To investigate the prevalence and associated factors of retinal nerve fiber layer defects (RNFLDs) in a Korean population. METHODS: The Korea National Health and Nutrition Examination Survey (KNHANES) is a population-based study using a complex, stratified, multistage, probability-cluster survey. We performed a review of 2008-2012 data from the KNHANES. Two masked ophthalmologists evaluated fundus photography to detect RNFLDs. All participants underwent ocular and systemic evaluations...
2017: PloS One
https://www.readbyqxmd.com/read/28980561/-heidelberg-retinal-tomography-of-the-optic-disc-in-the-early-diagnosis-of-glaucoma
#13
V A Machekhin, O L Fabrikantov
AIM: To analyze anatomical and topographic optic disc parameters with account to the disc area in glaucoma suspects. MATERIAL AND METHODS: The study included 302 patients (408 eyes) aged 25 to 76 years (the mean age of 50.5±12.5 years); men and women roughly equal in number. The eyes were divided into 8 groups depending on the disc area, which ranged from 0.89 to 3.5 mm2. With HRT, 11 global and sector optic disc parameters were examined, 4 of which (disc area, rim area, cup/disc ratio, mean RNFL thickness) are presented in this paper...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28973373/progressive-deformation-of-the-optic-nerve-head-and-peripapillary-structures-by-graded-horizontal-duction
#14
Soh Youn Suh, Alan Le, Andrew Shin, Joseph Park, Joseph L Demer
Purpose: We investigated the effect of graded range of horizontal duction on the shape of the peripapillary Bruch's membrane (ppBM) and optic nerve head (ONH). Methods: In 50 eyes of 25 normal subjects, the ONH and peripapillary retina were imaged by optical coherence tomography (OCT) in central gaze and incremental angles of add- and abduction. Displacements of the Bruch's membrane opening (BMO), optic cup (OC), and change in ONH angle in eccentric gazes were compared to those of central gaze, in add- and abduction...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28964804/differences-in-oct-assessment-of-bruch-membrane-opening-compared-to-stereoscopic-photography-for-estimating-cup-to-disc-ratio
#15
Jean-Claude Mwanza, Linda Y Huang, Donald L Budenz, Wei Shi, Gintien Huang, Richard K Lee
PURPOSE: To compare the vertical and horizontal cup-to-disc ratio (VCDR, HCDR) by an updated optical coherence tomography (OCT) Bruch's membrane opening (BMO) algorithm and stereoscopic optic disc photograph readings by glaucoma specialists. DESIGN: Reliability analysis. METHODS: 195 eyes (116 glaucoma and 79 glaucoma suspects) of 99 patients with stereoscopic photos and OCT scans of the optic discs taken during the same visit were compared...
September 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28947898/an-automatic-image-processing-system-for-glaucoma-screening
#16
Ahmed Almazroa, Sami Alodhayb, Kaamran Raahemifar, Vasudevan Lakshminarayanan
Horizontal and vertical cup to disc ratios are the most crucial parameters used clinically to detect glaucoma or monitor its progress and are manually evaluated from retinal fundus images of the optic nerve head. Due to the rarity of the glaucoma experts as well as the increasing in glaucoma's population, an automatically calculated horizontal and vertical cup to disc ratios (HCDR and VCDR, resp.) can be useful for glaucoma screening. We report on two algorithms to calculate the HCDR and VCDR. In the algorithms, level set and inpainting techniques were developed for segmenting the disc, while thresholding using Type-II fuzzy approach was developed for segmenting the cup...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28944197/influence-of-corneal-power-on-circumpapillary-retinal-nerve-fiber-layer-and-optic-nerve-head-measurements-by-spectral-domain-optical-coherence-tomography
#17
Kazunori Hirasawa, Nobuyuki Shoji
AIM: To evaluate the influence of corneal power on circumpapillary retinal nerve fiber layer (cpRNFL) and optic nerve head (ONH) measurements by spectral-domain optical coherence tomography (SD-OCT). METHODS: Twenty-five eyes of 25 healthy participants (mean age 23.6±3.6y) were imaged by SD-OCT using horizontal raster scans. Disposable soft contact lenses of different powers (from -11 to +5 diopters including 0 diopter) were worn to induce 2-diopter changes in corneal power...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28937823/optic-disc-parameters-of-myopic-children-with-atropine-treatment
#18
Li-Wei Chan, Yi-Ting Hsieh, Wei-Cherng Hsu, Han-Chih Cheng, Elizabeth P Shen
PURPOSE: To characterize optic disc parameters, retinal nerve fiber layer thickness (RNFLT), and the intraocular pressure (IOP) of myopic children under continual topical 0.25% atropine treatment. METHODS: From October 1, 2010 to September 31, 2011, 67 eyes of 35 myopic children were recruited. The children were treated with 0.25% atropine nightly for myopia control. Visual acuity, refraction, IOP, axial length (AL, IOL Master), RNFLT, and optic disc parameters (Stratus OCT) were measured at enrollment and every 2 months...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28928265/outcomes-of-lensectomy-and-risk-factors-for-failure-in-spherophakic-eyes-with-secondary-glaucoma
#19
Divya P Rao, Praveen J John, Mohammed Hasnat Ali, Ramesh Kekunnaya, Subhadra Jalali, Chandra Sekhar Garudadri, Sirisha Senthil
PURPOSE: To report the outcomes of lensectomy in spherophakic eyes with subluxated or dislocated crystalline lenses and secondary glaucoma. METHODS: Lensectomy was performed in 52 eyes, 36 eyes with lens subluxation and 16 eyes with lens dislocation with secondary glaucoma from 1991 to 2016. Glaucoma was diagnosed based on intraocular pressure (IOP) ≥22 mm Hg and/or glaucomatous optic disc damage. Complete success was defined as IOP ≥5 and ≤21 mm Hg without antiglaucoma medications (AGMs) or surgery, and eyes needing oral AGM or surgical intervention for IOP control or those with complication causing loss of light perception were considered failure...
September 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28927166/experimental-evaluation-of-respirable-dust-and-crystalline-silica-controls-during-simulated-performance-of-stone-countertop-fabrication-tasks-with-powered-hand-tools
#20
David L Johnson, Margaret L Phillips, Chaolong Qi, Anthony T Van, Danielle A Hawley
Objectives: Workers who fabricate stone countertops using hand tools are at risk of silicosis from overexposure to respirable crystalline silica. This study explored the efficacy of simple engineering controls that can be used for dust suppression during use of hand tools by stone countertop fabricators. Methods: Controlled experiments were conducted to measure whether wet methods and on-tool local exhaust ventilation (LEV) reduced respirable dust (RD) exposures during use of various powered hand tools on quartz-rich engineered stone...
July 1, 2017: Annals of Work Exposures and Health
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