keyword
MENU ▼
Read by QxMD icon Read
search

Optic cup

keyword
https://www.readbyqxmd.com/read/29434244/characterization-of-retinal-ganglion-cell-and-optic-nerve-phenotypes-caused-by-sustained-intracranial-pressure-elevation-in-mice
#1
Guofu Shen, Schuyler Link, Sandeep Kumar, Derek M Nusbaum, Dennis Y Tse, Yingbin Fu, Samuel M Wu, Benjamin J Frankfort
Elevated intracranial pressure (ICP) can result in multiple neurologic sequelae including vision loss. Inducible models of ICP elevation are lacking in model organisms, which limits our understanding of the mechanism by which increased ICP impacts the visual system. We adapted a mouse model for the sustained elevation of ICP and tested the hypothesis that elevated ICP impacts the optic nerve and retinal ganglion cells (RGCs). ICP was elevated and maintained for 2 weeks, and resulted in multiple anatomic changes that are consistent with human disease including papilledema, loss of physiologic cupping, and engorgement of the optic nerve head...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432780/how-mechanical-forces-shape-the-developing-eye
#2
REVIEW
Hadi S Hosseini, Larry A Taber
In the vertebrate embryo, the eyes develop from optic vesicles that grow laterally outward from the brain tube and contact the overlying surface ectoderm. Within the region of contact, each optic vesicle and the surface ectoderm thicken to form placodes, which then invaginate to create the optic cup and lens pit, respectively. Eventually, the optic cup becomes the retina, while the lens pit closes to form the lens vesicle. Here, we review current hypotheses for the physical mechanisms that create these structures and present novel three-dimensional computer (finite-element) models to illustrate the plausibility and limitations of these hypotheses...
February 9, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29422665/application-of-bayes-to-the-prediction-of-referral-decisions-made-by-specialist-optometrists-in-relation-to-chronic-open-angle-glaucoma
#3
J C Gurney, E Ansari, D Harle, N O'Kane, R V Sagar, M C M Dunne
PURPOSE: To determine the accuracy of a Bayesian learning scheme (Bayes') applied to the prediction of clinical decisions made by specialist optometrists in relation to the referral refinement of chronic open angle glaucoma. METHODS: This cross-sectional observational study involved collection of data from the worst affected or right eyes of a consecutive sample of cases (n = 1,006) referred into the West Kent Clinical Commissioning Group Community Ophthalmology Team (COT) by high street optometrists...
February 9, 2018: Eye
https://www.readbyqxmd.com/read/29416313/measurement-of-the-hypotenuse-of-the-vertical-optic-nerve-head-cup-with-spectral-domain-optical-coherence-tomography-for-the-structural-diagnosis-of-glaucoma
#4
Fabio Lavinsky, Camila Zanella Benfica, Nédio Castoldi, Anne Elise Cruz do Carmo Chaves, Paulo Augusto de Arruda Mello
Purpose: To evaluate the hypotenuse of the vertical optic nerve head cup (HVOC), measured using the length and depth of the cup obtained with enhanced depth imaging spectral-domain optic coherence tomography (SD-OCT), as a biomarker for glaucoma diagnosis. Methods: This was a prospective cross-sectional study of patients with glaucoma and controls. SD-OCT was performed in all participants to assess average circumpapillary retinal nerve fiber layer (RNFL) thickness...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29411011/activation-of-the-nfat-calcium-signaling-pathway-in-human-lamina-cribrosa-cells-in-glaucoma
#5
Mustapha Irnaten, Alexander Zhdanov, Deirdre Brennan, Thomas Crotty, Abbot Clark, Dmitri Papkovsky, Colm O'Brien
Purpose: Optic nerve cupping in glaucoma is characterized by remodeling of the extracellular matrix (ECM) and fibrosis in the lamina cribrosa (LC). We have previously shown that glaucoma LC cells express raised levels of ECM genes and have elevated intracellular calcium ([Ca2+]i). Raised [Ca2+]i is known to promote proliferation, activation, and contractility in fibroblasts via the calcineurin-NFAT (nuclear factor of activated T-cells) signaling pathway. In this study, we examine NFAT expression in normal and glaucoma LC cells, and investigate the effect of cyclosporin A (CsA, a known inhibitor of NFAT activity) on [Ca2+]i and ECM gene expression in normal and glaucoma LC cells...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29403593/upcoming-methods-and-specifications-of-continuous-intraocular-pressure-monitoring-systems-for-glaucoma
#6
Amir Molaei, Vahid Karamzadeh, Sare Safi, Hamed Esfandiari, Javad Dargahi, Mohammad Azam Khosravi
Glaucoma is the leading cause of irreversible blindness and vision loss in the world. Although intraocular pressure (IOP) is no longer considered the only risk factor for glaucoma, it is still the most important one. In most cases, high IOP is secondary to trabecular meshwork dysfunction. High IOP leads to compaction of the lamina cribrosa and subsequent damage to retinal ganglion cell axons. Damage to the optic nerve head is evident on funduscopy as posterior bowing of the lamina cribrosa and increased cupping...
January 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29400372/evaluation-of-the-optic-nerve-and-scleral-choroidal-retinal-layer-with-ultrasound-elastography-in-glaucoma-and-physiological-optic-nerve-head-cupping
#7
Özkan Özen, Murat Atabey Özer, Alptekin Tosun, Serkan Özen
AIM: To evaluate the strain ratio of the optic nerve and retina-choroid-sclera (RCS) layers in individuals with physiological optic disc cupping (PC) and glaucoma patients using strain elastography. MATERIAL AND METHODS: We evaluated 56 eyes of 56 subjects (20 eyes with glaucoma, 19 eyes with PC, and 17 normal eyes). The strain ratio of orbital fat to optic nerve (SROFON) was calculated as the ratio of the optic nerve to intraconal fat tissue and the strain ratio of orbital fat to retina-choroid-sclera (SROFRCS) was calculated as the ratio of RCS layers to intraconal fat tissue...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29394205/differences-in-optic-nerve-head-retinal-nerve-fiber-layer-and-ganglion-cell-complex-parameters-between-caucasian-and-chinese-subjects
#8
Sunee Chansangpetch, Guofu Huang, Paul Coh, Catherine Oldenburg, Behzad Amoozgar, Mingguang He, Shan C Lin
PURPOSE: To compare optic nerve head (ONH), peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell complex (GCC) parameters between Caucasian and ethnic Chinese. METHODS: Normal subjects greater than 40 years old and self-identified as being Caucasian and Chinese were recruited. They were evaluated with spectral-domain optical coherence tomography (OCT) (RTVue-100, Optovue, Fremont, CA). Parameters related to the ONH, pRNFL and GCC analysis protocols were acquired...
February 1, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29390457/diagnostic-ability-of-macular-ganglion-cell-inner-plexiform-layer-thickness-in-glaucoma-suspects
#9
Xiaoyu Xu, Hui Xiao, Xinxing Guo, Xiangxi Chen, Linlin Hao, Jingyi Luo, Xing Liu
The purpose is to assess the diagnostic ability for early glaucoma of macular ganglion cell-inner plexiform layer (GCIPL) thickness in a Chinese population including glaucoma suspects.A total of 367 eyes with primary open-angle glaucoma (168 early glaucoma, 78 moderate glaucoma, and 121 advanced glaucoma), 52 eyes with ocular hypertension (OHT), 59 eyes with enlarged cup-to-disc ratio (C/D), and 225 normal eyes were included. GCIPL thickness (average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal), retinal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters were measured using Cirrus high-definition optical coherence tomography (OCT) and compared...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29370018/differentiating-occult-branch-retinal-artery-occlusion-from-primary-open-angle-glaucoma
#10
Michael Sullivan-Mee, Pathik Amin, Denise Pensyl, Suchitra Katiyar
SIGNIFICANCE: Clinical findings in occult branch retinal artery occlusion (BRAO) can mimic those of primary open-angle glaucoma (POAG). Because management of these conditions substantially differs, accurate diagnosis is crucial. Our comparative analysis indicates that specific macular thickness variables reliably differentiate these conditions and that macular scanning may enhance routine glaucoma evaluation. PURPOSE: The aim of this study was to identify clinical factors that reliably and efficiently identify occult BRAO masquerading as POAG...
January 25, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29335420/lamina-cribrosa-morphology-predicts-progressive-retinal-nerve-fiber-layer-loss-in-eyes-with-suspected-glaucoma
#11
Jeong-Ah Kim, Tae-Woo Kim, Robert N Weinreb, Eun Ji Lee, Michaël J A Girard, Jean Martial Mari
Although early diagnosis and treatment reduce the risk of blindness from glaucoma, the decision on whether or not to begin treatment in patients with suspected glaucoma is often a dilemma because the majority of patients never develop definite glaucoma. A growing body of evidences suggests that posterior bowing of the lamina cribrosa (LC) is the earliest structural change preceding the retinal nerve fiber layer (RNFL) loss in glaucomatous optic neuropathy. Based on this notion, we conducted a prospective study enrolling 87 eyes suspected of having glaucoma to investigate whether the future rate of RNFL loss is associated with the baseline LC curve evaluated by measuring the LC curve index (LCCI) using enhanced depth imaging optical coherence tomography...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334923/relationship-between-corneal-biomechanical-properties-and-structural-biomarkers-in-patients-with-normal-tension-glaucoma-a-retrospective-study
#12
Keunheung Park, Jonghoon Shin, Jiwoong Lee
BACKGROUND: We evaluated the relationships between corneal biomechanical properties and structural parameters in patients with newly diagnosed, untreated normal-tension glaucoma (NTG). METHODS: All subjects were evaluated using an Ocular Response Analyzer (ORA) measuring corneal hysteresis (CH) and the corneal resistance factor (CRF). Central corneal thickness (CCT), Goldmann applanation tonometric (GAT) data, axial length, and the spherical equivalent (SE), were also measured...
January 15, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#13
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29331255/an-automated-and-robust-image-processing-algorithm-for-glaucoma-diagnosis-from-fundus-images-using-novel-blood-vessel-tracking-and-bend-point-detection
#14
Soorya M, Ashish Issac, Malay Kishore Dutta
Glaucoma is an ocular disease which can cause irreversible blindness. The disease is currently identified using specialized equipment operated by optometrists manually. The proposed work aims to provide an efficient imaging solution which can help in automating the process of Glaucoma diagnosis using computer vision techniques from digital fundus images. The proposed method segments the optic disc using a geometrical feature based strategic framework which improves the detection accuracy and makes the algorithm invariant to illumination and noise...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29315318/correlative-light-and-immuno-electron-microscopy-of-retinal-tissue-cryostat-sections
#15
Thomas Burgoyne, Amelia Lane, William E Laughlin, Michael E Cheetham, Clare E Futter
Correlative light-electron microscopy (CLEM) is a powerful technique allowing localisation of specific macromolecules within fluorescence microscopy (FM) images to be mapped onto corresponding high-resolution electron microscopy (EM) images. Existing methods are applicable to limited sample types and are technically challenging. Here we describe novel methods to perform CLEM and immuno-electron microscopy (iEM) on cryostat sections utilising the popular FM embedding solution, optimal cutting temperature (OCT) compound...
2018: PloS One
https://www.readbyqxmd.com/read/29305369/radius-maumenee-syndrome-a-rare-cause-of-glaucoma
#16
Sara Homem de Melo Marques, Cláudia Farinha, Amélia Martins, Pedro Faria
Case presentation of a 41-year-old woman with long-standing bilateral eye injection whose clinical findings included bilateral episcleral vessel engorgement and tortuosity, raised intraocular pressure with open iridocorneal angles and left optic disc cupping. All remaining objective examination was normal. She underwent cranial and orbits CT and CT-angiography scans which were unremarkable. Optical coherence tomography of the peripapillary nerve fibre layer and automated perimetry were compatible with advanced glaucomatous damage on the left eye...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29280766/optic-nerve-avulsion-after-finger-poke-injury
#17
Tapan P Patel, Erica L Archer, Jonathan D Trobe
We present a case of optic nerve avulsion as a result of finger-poke injury to the eye. Spectral domain optical coherence tomography demonstrated a plunging cup indicative of the avulsion, a finding not previously described. Optic nerve avulsion is a form of anterior indirect traumatic optic neuropathy evoked by a sudden severe rotation at the junction of the optic nerve and globe induced, in this case, by penetration of the finger into the nasal orbit.
December 26, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29279773/automatic-cdr-estimation-for-early-glaucoma-diagnosis
#18
M A Fernandez-Granero, A Sarmiento, D Sanchez-Morillo, S Jiménez, P Alemany, I Fondón
Glaucoma is a degenerative disease that constitutes the second cause of blindness in developed countries. Although it cannot be cured, its progression can be prevented through early diagnosis. In this paper, we propose a new algorithm for automatic glaucoma diagnosis based on retinal colour images. We focus on capturing the inherent colour changes of optic disc (OD) and cup borders by computing several colour derivatives in CIE L∗a∗b∗ colour space with CIE94 colour distance. In addition, we consider spatial information retaining these colour derivatives and the original CIE L∗a∗b∗ values of the pixel and adding other characteristics such as its distance to the OD centre...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29279660/occult-optic-disc-pit-maculopathy-in-a-glaucomatous-disc
#19
Chokkahalli Krishnappa Nagesha, Pratyusha Ganne
Optic pits are congenital defects of the optic disc. Diagnosis of optic pit maculopathy is quite challenging in the absence of a clinically visible or optical coherence tomography (OCT) proven pit. One such scenario is when there is advanced glaucomatous cupping. We present a case in which OCT helped detect optic disc pit maculopathy in a 60-year-old female.
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29261773/classification-of-optic-disc-shape-in-glaucoma-using-machine-learning-based-on-quantified-ocular-parameters
#20
Kazuko Omodaka, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba, Toru Nakazawa
PURPOSE: This study aimed to develop a machine learning-based algorithm for objective classification of the optic disc in patients with open-angle glaucoma (OAG), using quantitative parameters obtained from ophthalmic examination instruments. METHODS: This study enrolled 163 eyes of 105 OAG patients (age: 62.3 ± 12.6, mean deviation of Humphrey field analyzer: -8.9 ± 7.5 dB). The eyes were classified into Nicolela's 4 optic disc types by 3 glaucoma specialists...
2017: PloS One
keyword
keyword
42144
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"