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https://www.readbyqxmd.com/read/27920583/intellijoint-hip-%C3%A2-a-3d-mini-optical-navigation-tool-for-improving-intraoperative-accuracy-during-total-hip-arthroplasty
#1
Wayne G Paprosky, Jeffrey M Muir
Total hip arthroplasty is an increasingly common procedure used to address degenerative changes in the hip joint due to osteoarthritis. Although generally associated with good results, among the challenges associated with hip arthroplasty are accurate measurement of biomechanical parameters such as leg length, offset, and cup position, discrepancies of which can lead to significant long-term consequences such as pain, instability, neurological deficits, dislocation, and revision surgery, as well as patient dissatisfaction and, increasingly, litigation...
2016: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/27918827/optic-radiations-microstructural-changes-in-glaucoma-and-association-with-severity-a-study-using-3tesla-magnetic-resonance-diffusion-tensor-imaging
#2
Laury Tellouck, Muriel Durieux, Pierrick Coupé, Audrey Cougnard-Grégoire, Joy Tellouck, Thomas Tourdias, Fanny Munsch, Arnaud Garrigues, Catherine Helmer, Florence Malet, Jean-François Dartigues, Vincent Dousset, Cécile Delcourt, Cédric Schweitzer
Purpose: To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. Methods: A total of 50 open-angle glaucoma subjects and 50 healthy age- and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27914989/transcriptome-analysis-of-adult-and-fetal-trabecular-meshwork-cornea-and-ciliary-body-tissues-by-rna-sequencing
#3
Megan Ulmer Carnes, R Rand Allingham, Allison Ashley-Koch, Michael A Hauser
PURPOSE: To characterize the transcriptional landscape of human adult and fetal trabecular meshwork (TM), cornea, and ciliary body (CB) tissues, and to evaluate the expression level of candidate genes selected from genetic association studies of primary-open angle glaucoma, central corneal thickness, intraocular pressure, vertical cup to disc ratio, and optic nerve parameters. METHODS: Deep RNA sequencing was performed on the selected human tissues. Transcriptome analyses were performed to 1) characterize the total number of expressed genes, 2) identify the most highly expressed genes, 3) estimate the number of novel transcripts, and 4) evaluate the expression of candidate genes in each tissue...
November 30, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27898470/lamina-cribrosa-in-glaucoma
#4
J Crawford Downs, Christopher A Girkin
PURPOSE OF REVIEW: This article presents, summarizes, and interprets the most recent advances in the study and understanding of the lamina cribrosa in glaucoma, in the context of previous work. RECENT FINDINGS: The lamina is an active living structure that responds to strain by changing morphology at the micro-scale and macro-scale in glaucoma. Changes in lamina cribrosa morphology in glaucoma include posteriorization of the laminar insertion into the sclera, increased cupping or depth of the lamina cribrosa, and the development of focal lamina cribrosa defects...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27889058/mutations-in-reep6-cause-autosomal-recessive-retinitis-pigmentosa
#5
Gavin Arno, Smriti A Agrawal, Aiden Eblimit, James Bellingham, Mingchu Xu, Feng Wang, Christina Chakarova, David A Parfitt, Amelia Lane, Thomas Burgoyne, Sarah Hull, Keren J Carss, Alessia Fiorentino, Matthew J Hayes, Peter M Munro, Ralph Nicols, Nikolas Pontikos, Graham E Holder, Chinwe Asomugha, F Lucy Raymond, Anthony T Moore, Vincent Plagnol, Michel Michaelides, Alison J Hardcastle, Yumei Li, Catherine Cukras, Andrew R Webster, Michael E Cheetham, Rui Chen
Retinitis pigmentosa (RP) is the most frequent form of inherited retinal dystrophy. RP is genetically heterogeneous and the genes identified to date encode proteins involved in a wide range of functional pathways, including photoreceptor development, phototransduction, the retinoid cycle, cilia, and outer segment development. Here we report the identification of biallelic mutations in Receptor Expression Enhancer Protein 6 (REEP6) in seven individuals with autosomal-recessive RP from five unrelated families...
December 1, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27870778/inter-visit-test-retest-variability-of-oct-in-glaucoma
#6
John Graham Pearce, Ted Maddess
PURPOSE: To determine the inter-visit test-retest variability (TRV) of a spectral domain optical coherence tomograph, the Topcon 3D OCT-2000, in the measurement of optic nerve head topography, peripapillary retinal nerve fiber layer (pRNFL), and macular ganglion cell complex (GCC) parameters in glaucoma patients. We also examine whether TRV with this instrument varies with the extent of glaucomatous damage. METHODS: Twenty-four subjects with varying degrees of glaucoma severity provided 41 eyes with usable results for the study...
November 19, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27857326/developing-a-trend-prediction-model-of-subsurface-damage-for-fixed-abrasive-grinding-of-optics-by-cup-wheels
#7
Zhichao Dong, Haobo Cheng
Fixed-abrasive grinding by cup wheels plays an important role in the production of precision optics. During cup wheel grinding, we strive for a large removal rate while maintaining fine integrity on the surface and subsurface layers (academically recognized as surface roughness and subsurface damage, respectively). This study develops a theoretical model used to predict the trend of subsurface damage of optics (with respect to various grinding parameters) in fixed-abrasive grinding by cup wheels. It is derived from the maximum undeformed chip thickness model, and it successfully correlates the pivotal parameters of cup wheel grinding with the subsurface damage depth...
November 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27853025/paradoxical-thinning-of-the-retinal-nerve-fiber-layer-after-reversal-of-cupping-a-case-report-of-primary-infantile-glaucoma
#8
Ta Chen Chang, Alana L Grajewski
The circumpapillary retinal nerve fiber layer (RNFL) thickness was assessed by spectral domain optical coherent tomography (SD-OCT) before and after surgical reduction of intraocular pressure in an eye with primary infantile glaucoma. In this case, a postoperative reduction of cupping and a subsequent increase in neuroretinal rim area is associated with a paradoxical thinning of the RNFL. This is the first-known characterization of cupping reversal using SD-OCT.
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27847468/synaptic-organization-of-microglomerular-clusters-in-the-lateral-and-medial-bulbs-of-the-honeybee-brain
#9
Theo Mota, Sabine Kreissl, Ana Carrasco Durán, Damien Lefer, Giovanni Galizia, Martin Giurfa
The honeybee Apis mellifera is an established model for the study of visual orientation. Yet, research on this topic has focused on behavioral aspects and has neglected the investigation of the underlying neural architectures in the bee brain. In other insects, the anterior optic tubercle (AOTU), the lateral (LX) and the central complex (CX) are important brain regions for visuospatial performances. In the central brain of the honeybee, a prominent group of neurons connecting the AOTU with conspicuous microglomerular synaptic structures in the LX has been recently identified, but their neural organization and ultrastructure have not been investigated...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27846047/optic-nerve-head-histopathology-in-high-axial-myopia
#10
Jost B Jonas, Kyoko Ohno-Matsui, Songhomitra Panda-Jonas
PURPOSE: To describe particularities of the optic nerve head of axially highly myopic eyes. METHODS: Measurements were obtained from enucleated globes and from population-based studies. RESULTS: Morphologic optic disc particularities in high axial myopia included enlarged disc size (secondary macrodisc), widening and temporal translocation of the papillary Bruch's membrane (BM) opening, parapapillary gamma and delta zone, elongation and thinning of lamina cribrosa and peripapillary scleral flange, steeper translamina cribrosa pressure gradient, decreased peripapillary choroid thickness, longer distance between peripapillary arterial circle and optic disc, optic cup flattening, presumably a stretching of the lamina cribrosa pores, and peripapillary intrachoroidal cavitations...
November 11, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27844144/identification-and-functional-characterisation-of-genetic-variants-in-olfm2-in-children-with-developmental-eye-disorders
#11
R Holt, S A Ugur Iseri, A W Wyatt, D A Bax, D Gold Diaz, C Santos, S Broadgate, R Dunn, J Bruty, Y Wallis, D McMullan, C Ogilvie, D Gerrelli, Y Zhang, Nicola Ragge
Anophthalmia, microphthalmia, and coloboma are a genetically heterogeneous spectrum of developmental eye disorders and affect around 30 per 100,000 live births. OLFM2 encodes a secreted glycoprotein belonging to the noelin family of olfactomedin domain-containing proteins that modulate the timing of neuronal differentiation during development. OLFM2 SNPs have been associated with open angle glaucoma in a case-control study, and knockdown of Olfm2 in zebrafish results in reduced eye size. From a cohort of 258 individuals with developmental eye anomalies, we identified two with heterozygous variants in OLFM2: an individual with bilateral microphthalmia carrying a de novo 19p13...
November 14, 2016: Human Genetics
https://www.readbyqxmd.com/read/27834960/diagnostic-ability-of-humphrey-perimetry-octopus-perimetry-and-optical-coherence-tomography-for-glaucomatous-optic-neuropathy
#12
B Monsalve, A Ferreras, P Calvo, J A Urcola, M Figus, J Monsalve, P Frezzotti
PurposeTo evaluate and compare the diagnostic accuracy of the Humphrey Field Analyzer (HFA), Octopus perimetry, and Cirrus OCT for glaucomatous optic neuropathy.MethodsEighty-eight healthy individuals and 150 open-angle glaucoma patients were consecutive and prospectively selected. Eligibility criteria for the glaucoma group were intraocular pressure ≥21 mm Hg and glaucomatous optic nerve head morphology. All subjects underwent a reliable standard automated perimetry with the HFA and Octopus perimeter, and were imaged with the Cirrus OCT...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27832941/thirteen-year-follow-up-of-optic-disc-hemorrhages-in-the-ocular-hypertension-treatment-study
#13
Donald L Budenz, Julia Beiser Huecker, Steven J Gedde, Mae Gordon, Michael Kass
PURPOSE: To determine the cumulative incidence of optic disc hemorrhage (ODH) before and after development of primary open angle glaucoma (POAG); determine the prognostic significance of ODH for the development of POAG; identify predictive factors for ODH. DESIGN: Prospective cohort study. METHODS: ODHs were evaluated in 3,236 eyes of 1618 Ocular Hypertension Treatment Study (OHTS) participants annually using stereoscopic optic disc photographs...
November 7, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27820422/the-relation-of-white-on-white-standard-automated-perimetry-short-wavelength-perimetry-and-optic-coherence-tomography-parameters-in-ocular-hypertension
#14
Ceyda Başkan, Özlem G Köz, Rahmi Duman, Sabite E Gökçe, Ahmet A Yarangümeli, Gülcan Kural
PURPOSE: The purpose of this study is to examine the demographics, clinical properties, and the relation between white-on-white standard automated perimetry (SAP), short wavelength automated perimetry (SWAP), and optical coherence tomographic (OCT) parameters of patients with ocular hypertension. MATERIALS AND METHODS: Sixty-one eyes of 61 patients diagnosed with ocular hypertension in the Ankara Numune Education and Research Hospital ophthalmology unit between January 2010 and January 2011 were included in this study...
December 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27816485/clinical-features-of-optic-nerve-head-in-healthy-newborns
#15
A Guevara D, J C Juarez E
OBJECTIVE: To determine the size and clinical features of the optical disc in healthy term infants. METHODOLOGY: Descriptive, observational, cross-sectional, and retrospective study based on complete medical records of newborns at the Angeles Pedregal Hospital, Mexico DF, from May to August 2015. The measurements of the optical disc and clinical features were obtained from digital photographs and evaluated by 2experts. Frequencies, means and standard deviation were calculated using the SPSS version 17...
November 2, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27797321/analysis-of-cellular-behavior-and-cytoskeletal-dynamics-reveal-a-constriction-mechanism-driving-optic-cup-morphogenesis
#16
María Nicolás-Pérez, Franz Kuchling, Joaquín Letelier, Rocío Polvillo, Jochen Wittbrodt, Juan R Martínez-Morales
Contractile actomyosin networks have been shown to power tissue morphogenesis. Although the basic cellular machinery generating mechanical tension appears largely conserved, tensions propagate in unique ways within each tissue. Here we use the vertebrate eye as a paradigm to investigate how tensions are generated and transmitted during the folding of a neuroepithelial layer. We record membrane pulsatile behavior and actomyosin dynamics during zebrafish optic cup morphogenesis by live imaging. We show that retinal neuroblasts undergo fast oscillations and that myosin condensation correlates with episodic contractions that progressively reduce basal feet area...
October 31, 2016: ELife
https://www.readbyqxmd.com/read/27784074/optic-nerve-head-biomechanic-and-iop-changes-before-and-after-the-injection-of-aflibercept-for-neovascular-age-related-macular-degeneration
#17
Gema Rebolleda, Beatriz Puerto, Victoria de Juan, Marta Gómez-Mariscal, Francisco José Muñoz-Negrete, Alfonso Casado
Purpose: We investigated the early effects of intravitreal aflibercept injection (IAI) on optic nerve head (ONH) morphology. Methods: All of the participants underwent applanation tonometry and enhanced depth imaging by spectral-domain optical coherence tomography immediately before injection, and within 5 and 30 minutes after IAI. Changes in the anterior lamina cribrosa surface depth, prelaminar tissue thickness (PTT), optic cup width, optic cup depth, and Bruch's membrane opening (BMO) were assessed...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27784063/a-novel-method-combining-vitreous-aspiration-and-intravitreal-aav2-8-injection-results-in-retina-wide-transduction-in-adult-mice
#18
Romain Da Costa, Carsten Röger, Jasmin Segelken, Maya Barben, Christian Grimm, John Neidhardt
Purpose: Gene therapies to treat eye disorders have been extensively studied in the past 20 years. Frequently, adeno-associated viruses were applied to the subretinal or intravitreal space of the eye to transduce retinal cells with nucleotide sequences of therapeutic potential. In this study we describe a novel intravitreal injection procedure that leads to a reproducible adeno-associated virus (AAV)2/8-mediated transduction of more than 70% of the retina. Methods: Prior to a single intravitreal injection of a enhanced green fluorescent protien (GFP)-expressing viral suspension, we performed an aspiration of vitreous tissue from wild-type C57Bl/6J mice...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27779752/the-inheritance-of-juvenile-onset-primary-open-angle-glaucoma
#19
REVIEW
Viney Gupta, Bindu I Somarajan, Shikha Gupta, Abadh Kishore Chaurasia, Sandip Kumar, Paromita Dutta, Vipin Gupta, Arundhati Sharma, Bamidele O Tayo, Ken Nischal
Juvenile onset open angle glaucoma affects patients before 40years of age, who present with high intraocular pressure and deep steep cupping of the optic nerve head. While it was considered to be inherited in an autosomal dominant fashion, recent studies have shown an autosomal recessive pattern as well as sporadic occurrence of the disease in several families. In this review, we analyze the genetic basis of the disease along with common mutations and their association with JOAG. We also analyzed the inheritance patterns in a large group of unrelated JOAG patients (n = 336) from Northern India wherein the prevalence of familial occurrence was assessed and segregation analysis performed, to determine the mode of inheritance...
October 25, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27778447/distribution-of-intraocular-pressure-central-corneal-thickness-and-vertical-cup-to-disc-ratio-in-a-healthy-iranian-population-the-yazd-eye-study
#20
Mohammad Pakravan, Mohammad Ali Javadi, Shahin Yazdani, Elham Ghahari, Zohreh Behroozi, Reza Soleimanizad, Sasan Moghimi, Naveed Nilforoushan, Reza Zarei, Yadollah Eslami, Mahmood Ghassami, Hossein Ziaei, Marzieh Katibeh, Hanif Tabesh, Mehdi Yaseri
PURPOSE: To determine the distribution of intraocular pressure (IOP), central corneal thickness (CCT) and vertical cup-to-disc ratio (VCDR) in the healthy Iranian population. METHODS: This population-based, epidemiologic study evaluated Iranian aged 40-80 years, residing in Yazd, Iran, in 2010-2011. Eligible subjects were selected by cluster random sampling. Each participant underwent an interview and ophthalmologic examination including slit lamp examination, Goldmann applanation tonometry, binocular optic disc evaluation, stereoscopic fundus photography, ultrasonic pachymetry and visual field testing...
October 25, 2016: Acta Ophthalmologica
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