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Lymphatic endothelial cells

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https://www.readbyqxmd.com/read/29790306/the-role-of-novel-prognostic-markers-prox1-and-foxc2-in-carcinogenesis-of-oral-squamous-cell-carcinoma
#1
Neha S Agnihotri, Madhusudan Astekar
Oral squamous cell carcinoma is the most common malignant tumor of the head and neck regions and accounts for more than 90% of cancers in the oral cavity. The angiogenesis, lymphangiogenesis and epithelial mesenchymal transition are known to be pivotal for tumor progression and metastasis. In the last decade, much data has been generated concerning the molecular mechanisms of angiogenesis, lymphangiogenesis and its significance in pathological conditions. The main angiogenic and lymphangiogenic factors have been identified as vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR-2), forkhead box (FOX) C2 while vascular endothelial growth factor C/D (VEGF-C/D), vascular endothelial growth factor receptor 3 (VEGFR-3), Prospero homeobox 1 (PROX1), LYVE-1, podoplanin, Tie/Angioprotein (Ang) 2 and EphrinB2 respectively...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29779031/a-novel-ex-vivo-mouse-mesometrium-culture-model-for-investigating-angiogenesis-in-microvascular-networks
#2
Ariana D Suarez-Martinez, Susanne Bierschenk, Katie Huang, Dana Kaplan, Carolyn L Bayer, Stryder M Meadows, Markus Sperandio, Walter L Murfee
BACKGROUND: The development of models that incorporate intact microvascular networks enables the investigation of multicellular dynamics during angiogenesis. Our laboratory introduced the rat mesentery culture model as such a tool, which would be enhanced with mouse tissue. Since mouse mesentery is avascular, an alternative is mouse mesometrium, the connective tissue of uterine horns. The study's objective was to demonstrate that mouse mesometrium contains microvascular networks that can be cultured to investigate multicellular dynamics during angiogenesis...
May 18, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29778674/innate-effector-cells-in-angiogenesis-and-lymphangiogenesis
#3
REVIEW
Gilda Varricchi, Stefania Loffredo, Maria Rosaria Galdiero, Giancarlo Marone, Leonardo Cristinziano, Francescopaolo Granata, Gianni Marone
Angiogenesis and lymphangiogenesis are distinct and complex processes requiring a finely tuned balance between stimulatory and inhibitory signals. During adulthood, angiogenesis and lymphangiogenesis are activated at sites of tumor growth, tissue injury and remodeling, and chronic inflammation. Vascular endothelial growth factors (VEGFs), angiopoietin (ANGPTs) and a multitude of additional signaling molecules play distinct roles in the modulation of angiogenesis/lymphangiogenesis. VEGFs and ANGPTs activate specific tyrosine kinase receptor (e...
May 17, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29777777/mir-128-3p-directly-targets-vegfc-vegfr3-to-modulate-the-proliferation-of-lymphatic-endothelial-cells-through-ca-2-signaling
#4
Jie Zhou, Zhiyou He, Le Guo, Jizhang Zeng, Pengfei Liang, Licheng Ren, Minghua Zhang, Pihong Zhang, Xiaoyuan Huang
Lymphangiogenesis has been regarded as a physiological response to pathologic stimuli. The abnormal proliferation of lymphatic endothelial cell (LECs) and lymphangiogenesis is involved in the development of lymphatic disorders. Reportedly, VEGFC/VEGFR3 plays a key role in lymphangiogenesis; moreover, VEGFC/VEGFR3 exerts their cellular effects through activation of Ca2+ signaling in several cell types. Herein, we demonstrated that VEGFC significantly up-regulated LEC proliferation through VEGFR3; moreover, VEGFC/VEGFR3 induced Ca2+ signaling activation...
May 16, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29776755/neutral-ph-and-low-glucose-degradation-product-dialysis-fluids-induce-major-early-alterations-of-the-peritoneal-membrane-in-children-on-peritoneal-dialysis
#5
Betti Schaefer, Maria Bartosova, Stephan Macher-Goeppinger, Peter Sallay, Peter Vörös, Bruno Ranchin, Karel Vondrak, Gema Ariceta, Ariane Zaloszyc, Aysun K Bayazit, Uwe Querfeld, Rimante Cerkauskiene, Sara Testa, Christina Taylan, Johan VandeWalle, YokChin Yap, Rafael T Krmar, Rainer Büscher, Anne K Mühlig, Dorota Drozdz, Salim Caliskan, Felix Lasitschka, Sahar Fathallah-Shaykh, Enrico Verrina, Günter Klaus, Klaus Arbeiter, Raj Bhayadia, Anette Melk, Philipp Romero, Bradley A Warady, Franz Schaefer, Akos Ujszaszi, Claus Peter Schmitt
The effect of peritoneal dialysates with low-glucose degradation products on peritoneal membrane morphology is largely unknown, with functional relevancy predominantly derived from experimental studies. To investigate this, we performed automated quantitative histomorphometry and molecular analyses on 256 standardized peritoneal and 172 omental specimens from 56 children with normal renal function, 90 children with end-stage kidney disease at time of catheter insertion, and 82 children undergoing peritoneal dialysis using dialysates with low-glucose degradation products...
May 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29773646/a-blood-capillary-plexus-derived-population-of-progenitor-cells-contributes-to-genesis-of-the-dermal-lymphatic-vasculature-during-embryonic-development
#6
Cathy Pichol-Thievend, Kelly L Betterman, Xiaolei Liu, Wanshu Ma, Renae Skoczylas, Emmanuelle Lesieur, Frank L Bos, Dorte Schulte, Stefan Schulte-Merker, Benjamin M Hogan, Guillermo Oliver, Natasha L Harvey, Mathias Francois
Despite the essential role of the lymphatic vasculature in tissue homeostasis and disease, knowledge of the organ-specific origins of lymphatic endothelial progenitor cells remains limited. The assumption that most murine embryonic lymphatic endothelial cells (LECs) are venous derived has recently been challenged. Here, we show that the embryonic dermal blood capillary plexus constitutes an additional, local source of LECs that contributes to the formation of the dermal lymphatic vascular network. We describe a novel mechanism whereby rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1 -dependent manner to establish discrete LEC clusters...
May 17, 2018: Development
https://www.readbyqxmd.com/read/29772409/lymphatics-in-the-liver
#7
REVIEW
Masatake Tanaka, Yasuko Iwakiri
The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma. Despite its apparent relevance in healthy and diseased livers as these and other observations indicate, the hepatic lymphatic system has been poorly studied. With knowledge of the lymphatic system in other organs and tissues incorporated, this review article addresses the current knowledge of the hepatic lymphatic system and the potential role of lymphatic endothelial cells in the health and the disease of the liver and concludes with a brief description on future directions of the study of the hepatic lymphatic system...
May 14, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29760194/differential-roles-of-lt%C3%AE-r-in-endothelial-cell-subsets-for-lymph-node-organogenesis-and-maturation
#8
Zhongnan Wang, Qian Chai, Mingzhao Zhu
Cellular cross-talk mediated by lymphotoxin αβ-lymphotoxin β receptor (LTβR) signaling plays a critical role in lymph node (LN) development. Although the major role of LTβR signaling has long been considered to occur in mesenchymal lymphoid tissue organizer cells, a recent study using a VE-cadherincre Ltbrfl/fl mouse model suggested that endothelial LTβR signaling contributes to the formation of LNs. However, the detailed roles of LTβR in different endothelial cells (ECs) in LN development remain unknown...
May 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29760193/expression-of-the-atypical-chemokine-receptor-ackr4-identifies-a-novel-population-of-intestinal-submucosal-fibroblasts-that-preferentially-expresses-endothelial-cell-regulators
#9
Carolyn A Thomson, Serge A van de Pavert, Michelle Stakenborg, Evelien Labeeuw, Gianluca Matteoli, Allan McI Mowat, Robert J B Nibbs
Atypical chemokine receptors (ACKRs) are expressed by discrete populations of stromal cells at specific anatomical locations where they control leukocyte migration by scavenging or transporting chemokines. ACKR4 is an atypical receptor for CCL19, CCL21, and CCL25. In skin, ACKR4 plays indispensable roles in regulating CCR7-dependent APC migration, and there is a paucity of migratory APCs in the skin-draining lymph nodes of Ackr4 -deficient mice under steady-state and inflammatory conditions. This is caused by loss of ACKR4-mediated CCL19/21 scavenging by keratinocytes and lymphatic endothelial cells...
May 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29752774/mesenchymal-stem-cells-promote-lymphangiogenic-properties-of-lymphatic-endothelial-cells
#10
Jan W Robering, Annika Weigand, Romy Pfuhlmann, Raymund E Horch, Justus P Beier, Anja M Boos
Lymphatic metastasis is one of the main prognostic factors concerning long-term survival of cancer patients. In this regard, the molecular mechanisms of lymphangiogenesis are still rarely explored. Also, the interactions between stem cells and lymphatic endothelial cells (LEC) in humans have not been well examined. Therefore, the main objective of this study was to assess the interactions between mesenchymal stem cells (MSC) and LEC using in vitro angiogenesis assays. Juvenile LEC were stimulated with VEGF-C, bFGF, MSC-conditioned medium (MSC-CM) or by co-culture with MSC...
May 11, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29751081/lifr-promotes-tumor-angiogenesis-by-up-regulating-il-8-levels-in-colorectal-cancer
#11
Hao-Xuan Wu, Xi Cheng, Xiao-Qian Jing, Xiao-Pin Ji, Xian-Ze Chen, Ya-Qi Zhang, Yong-Gang He, Kun Liu, Feng Ye, Han-Xing Sun, Hao-Ji Gao, Zi-Jia Song, Huo Wu, Xiao-Jian Zhang, Tao Zhang, Ren Zhao
Leukemia inhibitory factor receptor (LIFR) has been documented as a cancer promoter and to be present at high levels in various types of tumor tissues. In our search for molecules prognostic of colorectal cancer (CRC), we found high levels of LIFR in CRC tissue samples. Further analyses revealed that LIFR was indeed prognostic of CRC patient survival, and was associated with tumor size, lymphatic metastasis and stages. LIFR was found to promote tumor growth, metastasis and angiogenesis both in vitro and in vivo...
May 8, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29749465/12-s-hete-induces-lymph-endothelial-cell-retraction-in-vitro-by-upregulation-of-sox18
#12
Adryan Fristiohady, Daniela Milovanovic, Sigurd Krieger, Nicole Huttary, Chi Huu Nguyen, Jose Basilio, Walter Jäger, Rainer De Martin, Georg Krupitza
Metastasising breast cancer cells communicate with adjacent lymph endothelia, intravasate and disseminate through lymphatic routes, colonise lymph nodes and finally metastasize to distant organs. Thus, understanding and blocking intravasation may attenuate the metastatic cascade at an early step. As a trigger factor, which causes the retraction of lymph endothelial cells (LECs) and opens entry ports for tumour cell intravasation, MDA-MB231 breast cancer cells secrete the pro-metastatic arachidonic acid metabolite, 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid [12(S)-HETE]...
April 26, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29746818/lymphatic-markers-in-the-human-optic-nerve
#13
A Trost, C Runge, D Bruckner, A Kaser-Eichberger, B Bogner, C Strohmaier, H A Reitsamer, F Schroedl
Tissues of the central nervous system (CNS), including the optic nerve (ON), are considered a-lymphatic. However, lymphatic structures have been described in the dura mater of human ON sheaths. Since it is known that lymphatic markers are also expressed by single non-lymphatic cells, these results need confirmation according to the consensus statement for the use of lymphatic markers in ophthalmologic research. The aim of this study was to screen for the presence of lymphatic structures in the adult human ON using a combination of four lymphatic markers...
May 7, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29730294/live-imaging-reveals-a-conserved-role-of-fatty-acid-%C3%AE-oxidation-in-early-lymphatic-development-in-zebrafish
#14
Annalisa Zecchin, Brian Wong, Bieke Tembuyser, Joris Souffreau, An Van Nuffelen, Sabine Wyns, Stefan Vinckier, Peter Carmeliet, Mieke Dewerchin
During embryonic development, lymphatic endothelial cells (LECs) differentiate from venous endothelial cells (VECs), a process that is tightly regulated by several genetic signals. While the aquatic zebrafish model is regularly used for studying lymphangiogenesis and offers the unique advantage of time-lapse video-imaging of lymphatic development, some aspects of lymphatic development in this model differ from those in the mouse. It therefore remained to be determined whether fatty acid β-oxidation (FAO), which we showed to regulate lymphatic formation in the mouse, also co-determines lymphatic development in this aquatic model...
May 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29730230/resistin-facilitates-vegf-c-associated-lymphangiogenesis-by-inhibiting-mir-186-in-human-chondrosarcoma-cells
#15
Chen-Ming Su, Chih-Hsin Tang, Meng-Ju Chi, Chih-Yang Lin, Yi-Chin Fong, Yueh-Ching Liu, Wei-Cheng Chen, Shih-Wei Wang
Chondrosarcoma is a common primary malignant tumor of the bone that can metastasize through the vascular system to other organs. A key step in the metastatic process, lymphangiogenesis, involves vascular endothelial growth factor-C (VEGF-C). However, the effects of lymphangiogenesis in chondrosarcoma metastasis remain to be clarified. Accumulating evidence shows that resistin, a cytokine secreted from adipocytes and monocytes, also promotes tumor pathogenesis. Notably, chondrosarcoma can easily metastasize...
May 3, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29729720/small-intestinal-lymphatic-hypoplasia-in-three-dogs-with-clinical-signs-of-protein-losing-enteropathy
#16
J M Malatos, N A Kurpios, G E Duhamel
Intestinal lymphatic hypoplasia (ILH) is a rare but well-documented cause of protein-losing enteropathy (PLE) in human infants. To our knowledge, this condition has not been reported previously in veterinary medicine. Here we report the clinical and histopathological findings in three dogs that presented with clinical signs of PLE. The onset of PLE was early in an 18-month-old Great Pyrenees, while the other two dogs, a pug and a Tibetan terrier, had a later onset at 4 and 12 years of age, respectively. The presence of intestinal lymphatic and blood vessels was assessed by immunohistochemistry for human prospero homeobox 1 (prox-1), a lymphatic endothelial nuclear transcription factor and human von Willebrand factor (vWf), a marker of vascular endothelial cells, respectively...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29722325/induced-dural-lymphangiogenesis-facilities-soluble-amyloid-beta-clearance-from-brain-in-a-transgenic-mouse-model-of-alzheimer-s-disease
#17
Ya-Ru Wen, Jun-Hua Yang, Xiao Wang, Zhi-Bin Yao
Impaired amyloid-β clearance from the brain is a core pathological event in Alzheimer's disease. The therapeutic effect of current pharmacotherapies is unsatisfactory, and some treatments cause severe side effects. The meningeal lymphatic vessels might be a new route for amyloid-β clearance. This study investigated whether promoting dural lymphangiogenesis facilitated the clearance of amyloid-β from the brain. First, human lymphatic endothelial cells were treated with 100 ng/mL recombinant human vascular endothelial growth factor-C (rhVEGF-C) protein...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29717026/steroid-receptor-coactivator-1-interacts-with-nf-%C3%AE%C2%BAb-to-increase-the-vegfc-level-in-human-thyroid-cancer
#18
Bo Gao, Lingji Guo, Donglin Luo, Yan Jiang, Jianjie Zhao, Chengyi Mao, Yan Xu
Thyroid cancer is the most common endocrine cancer, and has a high incidence of lymphatic metastasis. Vascular endothelial growth factor C (VEGFC) is essential for development of lymphatic vessels and lymphatic metastases during carcinogenesis. Steroid receptor coactivator-1 (SRC-1) interacts with nuclear receptors and transcription factors to promote tumor proliferation and metastasis. However, the correlation between SRC-1 and VEGFC levels in the lymphatic metastases of thyroid cancer remains unclear. We analyzed 20 paired specimens of thyroid cancer tissue and normal thyroid tissue and found increased levels of SRC-1 and VEGFC proteins in 13/20 and 15/20 thyroid cancer specimens, respectively, when compared with those levels in specimens of normal thyroid tissue...
May 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29712618/lymphatic-endothelium-stimulates-melanoma-metastasis-and-invasion-via-mmp14-dependent-notch3-and-%C3%AE-1-integrin-activation
#19
Pirita Pekkonen, Sanni Alve, Giuseppe Balistreri, Silvia Gramolelli, Olga Tatti-Bugaeva, Ilkka Paatero, Otso Niiranen, Krista Tuohinto, Nina Perälä, Adewale Taiwo, Nadezhda Zinovkina, Pauliina Repo, Katherine Icay, Johanna Ivaska, Pipsa Saharinen, Sampsa Hautaniemi, Kaisa Lehti, Päivi M Ojala
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood. We show here that exposure of expansively growing human WM852 melanoma cells, but not singly invasive Bowes cells, to lymphatic endothelial cells (LEC) in 3D co-culture facilitates melanoma distant organ metastasis in mice. To dissect the underlying molecular mechanisms, we established LEC co-cultures with different melanoma cells originating from primary tumors or metastases...
May 1, 2018: ELife
https://www.readbyqxmd.com/read/29704765/lymphatic-endothelial-progenitor-cells-origins-and-roles-in-lymphangiogenesis
#20
REVIEW
Jan Kazenwadel, Natasha L Harvey
How are lymphatic vessels built? What are the sources of progenitor cells employed to construct lymphatic vessels during embryogenesis and in pathological situations? Are lymphatic vessels in different tissues built the same way? These questions have been highly topical and actively debated in the field of lymphangiogenesis research for more than 100 years. While embryonic veins and cells of mesenchymal origin have been recognised as sources of embryonic lymphatic endothelial cells for many years, recent advances in technology have revealed the existence of additional sources of lymphatic endothelial cells important for embryonic lymphangiogenesis...
April 25, 2018: Current Opinion in Immunology
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