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https://www.readbyqxmd.com/read/28944738/an-industry-update-the-latest-developments-in-therapeutic-delivery
#1
Oliver C Steinbach
The present industry update covers the period 1-30 June 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. The combination of drug and devices such as improved, safer injectables (see various market reports, companies Adamis and Baxter), patches (Microdermis) and (nano)carriers are moving increasingly from the R&D stage into clinical trials and toward the market. This addresses increased safety and effectiveness requirements, limiting physico-chemical properties of active ingredients, cost-effectiveness and patient comfort through ease of use...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944452/nano-pulse-stimulation-induces-potent-immune-responses-eradicating-local-breast-cancer-while-reducing-distant-metastases
#2
Siqi Guo, Yu Jing, Niculina I Burcus, Brittany P Lassiter, Royena Tanaz, Richard Heller, Stephen J Beebe
Nano-Pulse Stimulation (NPS) as a developing technology has been studied for minimally invasive, non-thermal local cancer elimination for more than a decade. Here we show that a single NPS treatment results in complete regression of the poorly immunogenic, metastatic 4T1-Luc mouse mammary carcinoma. Impressively, spontaneous distant organ metastases were largely prevented, even in those animals with incomplete tumor regression. All tumor-free mice were protected from secondary tumor cell challenge, demonstrating a vaccine-like effect...
September 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28944308/titanium-dioxide-nanoparticle-ingestion-alters-nutrient-absorption-in-an-in-vitro-model-of-the-small-intestine
#3
Zhongyuan Guo, Nicole J Martucci, Fabiola Moreno-Olivas, Elad Tako, Gretchen J Mahler
Ingestion of titanium dioxide (TiO2) nanoparticles from products such as agricultural chemicals, processed food, and nutritional supplements is nearly unavoidable. The gastrointestinal tract serves as a critical interface between the body and the external environment, and is the site of essential nutrient absorption. The goal of this study was to examine the effects of ingesting the 30 nm TiO2 nanoparticles with an in vitro cell culture model of the small intestinal epithelium, and to determine how acute or chronic exposure to nano-TiO2 influences intestinal barrier function, reactive oxygen species generation, proinflammatory signaling, nutrient absorption (iron, zinc, fatty acids), and brush border membrane enzyme function (intestinal alkaline phosphatase)...
January 2017: NanoImpact
https://www.readbyqxmd.com/read/28944259/observing-plasmon-damping-due-to-adhesion-layers-in-gold-nanostructures-using-electron-energy-loss-spectroscopy
#4
Steven J Madsen, Majid Esfandyarpour, Mark L Brongersma, Robert Sinclair
Gold plasmonic nanostructures with several different adhesion layers have been studied with monochromated electron energy loss spectroscopy in the scanning transmission electron microscope (STEM-EELS) and with surface enhanced Raman spectroscopy (SERS). Compared to samples with no adhesion layer, those with 2nm of Cr or Ti show broadened, lower intensity plasmon peaks as measured with EELS. This broadening is observed in both optically active ("bright") and inactive ("dark") plasmon modes. When the former are probed with SERS, the signal enhancement factor is lower for samples with Cr or Ti, another indication of reduced plasmon resonance...
February 15, 2017: ACS Photonics
https://www.readbyqxmd.com/read/28943385/perspectives-from-the-nanosafety-modelling-cluster-on-the-validation-criteria-for-q-sar-models-used-in-nanotechnology
#5
Tomasz Puzyn, Nina Jeliazkova, Haralambos Sarimveis, Richard L Marchese Robinson, Vladimir Lobaskin, Robert Rallo, Andrea-N Richarz, Agnieszka Gajewicz, Manthos G Papadopulos, Janna Hastings, Mark T D Cronin, Emilio Benfenati, Alberto Fernandez
Nanotechnology and the production of nanomaterials have been expanding rapidly in recent years. Since many types of engineered nanoparticles are suspected to be toxic to living organisms and to have a negative impact on the environment, the process of designing new nanoparticles and their applications must be accompanied by a thorough exposure risk analysis. (Quantitative) Structure-Activity Relationship ([Q]SAR) modelling creates promising options among the available methods for the risk assessment. These in silico models can be used to predict a variety of properties, including the toxicity of newly designed nanoparticles...
September 21, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28943207/supramolecular-nano-engineered-lipidic-carriers-based-on-diflunisal-phospholipid-complex-for-transdermal-delivery-qbd-based-optimization-characterization-and-preclinical-investigations-for-management-of-rheumatoid-arthritis
#6
Amanpreet Kaur, Bhupinder Singh Bhoop, Sanjay Chhibber, Gajanand Sharma, Vijay Singh Gondil, Om Prakash Katare
Diflunisal (DIF) is used for treatment of rheumatoid arthritis, osteoarthritis etc. DIF-phospholipid complex (DIF-PL complex) was prepared by solvent-evaporation method and characterized by molecular docking studies, SEM, FTIR, DSC, PXRD studies. Further, the DIF-PL complex was incorporated into supramolecular nano-engineered lipidic carriers (SNLCs) for transdermal delivery. The optimization exercise was done using Face centered cubic design (FCCD) after screening of variables by L8 Taguchi orthogonal array design...
September 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28942497/dynamic-n-glycoproteome-analysis-of-maize-seedling-leaves-during-de-etiolation-using-concanavalin-a-lectin-affinity-chromatography-and-a-nano-lc-ms-ms-based-itraq-approach
#7
Tian-Tian Bu, Jie Shen, Qing Chao, Zhuo Shen, Zhen Yan, Hai-Yan Zheng, Bai-Chen Wang
The identification of N -glycosylated proteins with information about changes in the level of N -glycosylation during de-etiolation provides a database that will aid further research on plant N -glycosylation and de-etiolation. N-glycosylation is one of the most prominent and abundant protein post-translational modifications in all eukaryotes and in plants it plays important roles in development, stress tolerance and immune responses. Because light-induced de-etiolation is one of the most dramatic developmental processes known in plants, seedlings undergoing de-etiolation are an excellent model for investigating dynamic proteomic profiles...
September 23, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28942247/hydrochars-and-phosphate-enhancing-the-transport-of-nanoparticle-silica-in-saturated-sands
#8
Cheng Liu, Nan Xu, Gang Feng, Dongmei Zhou, Xueying Cheng, Zuling Li
Due to the potential negative impact of nano silica (nSiO2) on human's health and living environments, it is important to investigate their transport in soil environments. Hydrochars has been widely used in agricultural soil and phosphate (P) is an important nutrient, thus the aggregation and transport of nSiO2 in saturated sand columns were investigated in single and binary systems of hydrochars and P. The experimental results showed that the nSiO2 aggregates can be restablized by the adsorption of P or the attachment of hydrochars at high IS (>100 mM) and low pH (<7...
September 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28942170/core-shell-structured-mzvi-ca-oh-2-particle-morphology-aggregation-and-corrosion
#9
Cai-Jie Wei, Xiao-Mao Wang, Xiao-Yan Li
A calcium hydroxide shell was coated onto the surface of micro-sized zero valent iron (mZVI) particles by hydrothermal approach in oversaturated Ca(OH)2 solution. The heterogeneous nucleation of nano-scale Ca(OH)2 particle on micro-scale spherical ZVI surface was clearly observed by scanning electronic microscope (SEM). The moderate solubility of Ca(OH)2 was demonstrated as the crucial factor in inducing slow nucleation rate and in facilitating the abundant growth of Ca(OH)2 nuclei on mZVI surface. The growth of shell thickness was found to obey the zero order kinetics with the rate constant at about 15nm/h...
September 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28942167/cracks-in-dried-deposits-of-hematite-ellipsoids-interplay-between-magnetic-and-hydrodynamic-torques
#10
Hisay Lama, Ranajit Mondal, Madivala G Basavaraj, Dillip K Satapathy
The orientation and morphology of cracks in coffee-ring like particulate deposit obtained by drying sessile drops containing anisotropic magnetic particles strongly depends on the magnitude of the applied magnetic field and its direction. This opens up the possibility of tuning the micro-structure of cracks via suitable manipulation of magnetic and hydrodynamic torques on the particles which has potential applications in nano-fabrication and field driven self-assembly. We report a systematic study of magnetic field driven self-assembly of hematite ellipsoids in sessile drops dried on solid substrates and resulting crack patterns...
September 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28942129/bone-regeneration-with-micro-nano-hybrid-structured-biphasic-calcium-phosphate-bioceramics-at-segmental-bone-defect-and-the-induced-immunoregulation-of-mscs
#11
Yu Zhu, Kun Zhang, Rui Zhao, Xingjiang Ye, Xuening Chen, Zhanwen Xiao, Xiao Yang, Xiangdong Zhu, Kai Zhang, Yujiang Fan, Xingdong Zhang
Adequate bone regeneration has been difficult to achieve at segmental bone defects caused by disease. The surface structure and phase composition of calcium phosphate bioceramic are crucial for its bioactivity and osteoinductivity. In the present study, biphasic calcium phosphate (BCP) bioceramics composed of micro-whiskers and nanoparticles hybrid-structured surface (hBCP) were fabricated via a hydrothermal reaction. The in vivo long bone defect model of beagle dogs implanted with hBCP bioceramics achieved a higher quality regenerated bone as compared to the traditional smooth-surface BCP control group...
September 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28941992/nano-delivery-system-targeting-to-cancer-stem-cell-cluster-of-differentiation-biomarkers
#12
REVIEW
Ahad Mokhtarzadeh, Soodabeh Hassanpour, Zahra Farajzadeh Vahid, Maryam Hejazi, Maryam Hashemi, Javad Ranjbari, Maryam Tabarzad, Saeed Noorolyai, Miguel de la Guardia
Cancer stem cells (CSCs) are one of the most important origins of cancer progression and metastasis. CSCs have unique self-renewal properties and diverse cell membrane receptors that induced the resistance to the conventional chemotherapeutic agents. Therefore, the therapeutic removal of CSCs could result in the cancer cure with lack of recurrence and metastasis. In this regard, targeting CSCs in accordance to their specific biomarkers is a talented attitude in cancer therapy. Various CSCs surface biomarkers have been described, which some of them exhibited similarities on different cancer cell types, while the others are cancer specific and have just been reported on one or a few types of cancers...
September 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28941777/new-pyrimidine-based-ligand-capped-gold-and-platinum-nano-particles-synthesis-characterization-antimicrobial-antioxidant-dna-interaction-and-in-vitro-anticancer-activities
#13
M Sankarganesh, P Adwin Jose, J Dhaveethu Raja, M P Kesavan, M Vadivel, J Rajesh, R Jeyamurugan, R Senthil Kumar, S Karthikeyan
In this research work, we have synthesized new pyrimidine based Schiff base ligand, 2-((4,6-dimethoxypyrimidine-2-yl)methyleneenamino)-6-methoxyphenol (DPMM) capped gold (Au) and platinum (Pt) nanoparticles (NPs) by modified Brust-Schiffrin method. The characteristics of DPMM-Au NPs and DPMM-Pt NPs have been examined by UV-Visible, FTIR, SEM, TEM and powder XRD analysis. SEM analysis result shows that surface morphology of the DPMM-Au NPs and DPMM-Pt NPs are in granular and spherical shape, correspondingly...
September 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28941674/do-oil-in-water-o-w-nano-emulsions-have-an-effect-on-survival-and-growth-of-bacteria
#14
Hani El Kadri, Putu Virgina Partha Devanthi, Tim W Overton, Konstantinos Gkatzionis
Nano-emulsions (typically droplet diameter<1μm) are common in foods, and have been extensively reported to present antimicrobial activity, however, the mechanism is not well defined, and some studies reported no effect. A review of the literature was conducted and revealed strongly contradictory reports regarding the antimicrobial effect of nano-emulsions even in reference to similar microbial species and formulations. Following up, this study aimed to investigate the effect of nano-emulsions on four bacterial species (Staphylococcus epidermidis, Bacillus cereus, Lactobacillus acidophilus and five Escherichia coli strains) possessing different surface charge and hydrophobicity...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28941652/silk-scaffolds-in-bone-tissue-engineering-an-overview
#15
REVIEW
Promita Bhattacharjee, Banani Kundu, Deboki Naskar, Hae-Won Kim, Tapas K Maiti, Debasis Bhattacharya, Subhas C Kundu
Bone tissue plays multiple roles in our day-to-day functionality. The frequency of accidental bone damage and disorder is increasing worldwide. Moreover, as the world population continues to grow, the percentage of the elderly population continues to grow, which results in an increased number of bone degenerative diseases. This increased elderly population pushes the need for artificial bone implants that specifically employ biocompatible materials. A vast body of literature is available on the use of silk in bone tissue engineering...
September 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28941340/-synthesis-of-multi-dimensional-nano-biostructures-and-biodevices-through-self-assembly-of-biomacromolecules
#16
Feng Ji, Dong Men, Dianbing Wang, Xian-En Zhang
There are various nanostructures in biological system. They are made of biological molecules via self-assembly with well-organized architectures and specific functions. These nanostructures can be grouped into lines, layers and cages, corresponding to one-, two- and three-dimensional structures, respectively. The bionanostructures can serve as the models or templates for biosynthesis of biodevices with desired functions by rational design. Proof-of-concept studies have shown their attractive performance in practical applications, e...
March 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28941234/tuning-the-size-of-poly-lactic-co-glycolic-acid-plga-nanoparticles-fabricated-by-nanoprecipitation
#17
Wei Huang, Chenming Zhang
Polymeric nanoparticles (PNPs) are promising drug carriers in cancer treatment. Size of the particles has a significant impact on drug loading, in vivo distribution, extravasation, intratumor diffusion and cell uptake, and thus is critical for the successful development of a drug delivery regime. However, methods for manufacturing PNPs of defined size are yet to be established. The goal of this study is to establish a method that can be used to fabricate PNPs with controlled size. We systematically investigated the factors that could impact the size of PNPs fabricated by nano-precipitation...
September 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28941223/fabrication-of-calcium-phosphate-based-nanocomposites-incorporating-dna-origami-gold-nanorods-and-anticancer-drugs-for-biomedical-applications
#18
Hongbo Zhang, Xiangmeng Qu, Hong Chen, Haixin Kong, Ruihua Ding, Dong Chen, Xu Zhang, Hao Pei, Hélder A Santos, Mingtan Hai, David A Weitz
DNA origami is designed by folding DNA strands at the nanoscale with arbitrary control. Due to its inherent biological nature, DNA origami is used in drug delivery for enhancement of synergism and multidrug resistance inhibition, cancer diagnosis, and many other biomedical applications, where it shows great potential. However, the inherent instability and low payload capacity of DNA origami restrict its biomedical applications. Here, this paper reports the fabrication of an advanced biocompatible nano-in-nanocomposite, which protects DNA origami from degradation and facilities drug loading...
September 22, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28941005/superior-potassium-ion-storage-via-vertical-mos2-nano-rose-with-expanded-interlayers-on-graphene
#19
Keyu Xie, Kai Yuan, Xin Li, Wei Lu, Chao Shen, Chenglu Liang, Robert Vajtai, Pulickel Ajayan, Bingqing Wei
Potassium has its unique advantages over lithium or sodium as a charge carrier in rechargeable batteries. However, progresses in K-ion battery (KIB) chemistry have so far been hindered by lacking suitable electrode materials to host the relatively large K(+) ions compared to its Li(+) and Na(+) counterparts. Herein, molybdenum disulfide (MoS2 ) "roses" grown on reduced graphene oxide sheets (MoS2 @rGO) are synthesized via a two-step solvothermal route. The as-synthesized MoS2 @rGO composite, with expanded interlayer spacing of MoS2 , chemically bonded between MoS2 and rGO, and a unique nano-architecture, displays the one of the best electrochemical performances to date as an anode material for nonaqueous KIBs...
September 22, 2017: Small
https://www.readbyqxmd.com/read/28940380/one-dimensional-phosphorus-nanostructures-from-nanorings-to-nanohelices
#20
Giuseppe Sansone, Lorenzo Maschio, Antti J Karttunen
Phosphorus nanorings and nanohelices - which were speculated to exist over 20 years ago - have been systematically derived from one parent structure and studied with quantum chemical methods. The (P8P2)n nanorings have been recently synthetized inside carbon nanotube templates, and our comprehensive analysis of possible structural arrangements strongly supports the possibility to experimentally realize the closely-related (P8P2)n nanohelices. The nanohelices possess very low stiffness, suggesting interesting mechanical properties with nano-spring -like behavior...
September 21, 2017: Chemistry: a European Journal
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