keyword
MENU ▼
Read by QxMD icon Read
search

Htm

keyword
https://www.readbyqxmd.com/read/28934571/htm-leader-looks-to-make-inroads-into-middle-eastern-healthcare
#1
Yahya S Ghazanfar
No abstract text is available yet for this article.
2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28934570/htm-departments-should-operate-like-a-business-response-to-cohen
#2
Kenneth E Maddock
No abstract text is available yet for this article.
2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28920441/new-insight-of-common-regulatory-pathways-in-human-trabecular-meshwork-cells-in-response-to-dexamethasone-and-prednisolone-using-an-integrated-quantitative-proteomics-swath-and-mrm-hr-mass-spectrometry
#3
Sze Wan Shan, Chi Wai Do, Thomas Chuen Lam, Ricky Pak Wing Kong, King Kit Li, Ka Man Chun, William Daniel Stamer, Chi Ho To
The molecular pathophysiology of corticosteroid-induced ocular hypertension (CIH) is not well understood. To determine the biological mechanisms of CIH, this study investigated protein expression profiles of human trabecular meshwork (hTM) cells in response to dexamethasone and prednisolone treatment. Both discovery-based Sequential Windowed data independent Acquisition of the Total High-resolution mass spectra (SWATH(TM)-MS) and targeted based high resolution multiple reaction monitoring (MRM-HR) confirmation were applied using a hybrid quadrupole-time-of-flight mass spectrometer...
September 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28915132/clinical-update-regarding-general-anesthesia-associated-neurotoxicity-in-infants-and-children
#4
M Ruth Graham
PURPOSE OF REVIEW: The U.S. Federal Drug Administration (FDA) recently released a warning stating that 'repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children's brains' (www.fda.gov/ucm582356.htm). The goal of this article is to review the most recent clinical studies which provide evidence that these concerns may be overstated for the majority of healthy young children who require surgery and anesthesia...
September 14, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28914823/hole-transporting-materials-for-printable-perovskite-solar-cells
#5
REVIEW
Paola Vivo, Jagadish K Salunke, Arri Priimagi
Perovskite solar cells (PSCs) represent undoubtedly the most significant breakthrough in photovoltaic technology since the 1970s, with an increase in their power conversion efficiency from less than 5% to over 22% in just a few years. Hole-transporting materials (HTMs) are an essential building block of PSC architectures. Currently, 2,2',7,7'-tetrakis-(N,N'-di-p-methoxyphenylamine)-9,9'-spirobifluorene), better known as spiro-OMeTAD, is the most widely-used HTM to obtain high-efficiency devices. However, it is a tremendously expensive material with mediocre hole carrier mobility...
September 15, 2017: Materials
https://www.readbyqxmd.com/read/28904819/prdx6-retards-senescence-and-restores-trabecular-meshwork-cell-health-by-regulating-reactive-oxygen-species
#6
Bhavana Chhunchha, Prerna Singh, W Daniel Stamer, Dhirendra P Singh
A progressive decline in antioxidant potential and accumulation of reactive oxygen species (ROS) are major causes of pathogenesis of several diseases, including glaucoma. Trabecular meshwork (TM) dysfunction resulting in higher intraocular pressure (IOP) is a hallmark of glaucoma, but its causes are unclear. Using human (h) TM cells derived from glaucomatous and normal subjects of different ages and cells facing oxidative-stress, we showed that specific loss of moonlighting antioxidant protein Peroxiredoxin (Prdx) 6 in aging or in glaucomatous TM cells caused ROS accumulation and pathobiological changes in TM cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28901244/inter-caste-lovers-suicide-pact-case-report-from-nepal
#7
Alok Atreya, Milan Shrestha, Jenash Acharya
Discrimination on cultural and ethnic grounds is a crime in Nepal. [Caste Based Discrimination and Untouchability (Offence and Punishment) Act, 2068 (2011) * * There are two different dates which reflect the Bikram Sambat which is the official Hindu calendar in Nepal. This calendar is 57 years ahead of Gregorian calendar. For example, 19 August 2017 AD is 03 Bhadra 2074 Bikram Sambat. Thus, the date 2068 is in Bikram Sambat, 2011 is per Gregorian calendar which is unofficial so kept in parenthesis. This text is available online from: http://www...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28875552/diphenylpyridine-amine-substituted-porphyrins-as-hole-transporting-materials-for-perovskite-solar-cells
#8
Un-Hak Lee, Randi Azmi, Septy Sinaga, Sunbin Hwang, Seung Hun Eom, Tae-Wook Kim, Sung Cheol Yoon, Sung-Yeon Jang, In Hwan Jung
The susceptibility of porphyrin derivatives to light-harvesting and charge-transport operations have enabled these materials to be employed in solar cell applications. The potential of porphyrin derivatives as hole-transporting materials (HTMs) for perovskite solar cells (PSCs) has recently been demonstrated, but research on the relationships between the porphyrin structure and device performance remains insufficient. In this work, a series of novel porphyrin derivatives, PZn-TPA-O, PZn-TPA, PZn-DPPA-O and PZn-DPPA, are developed and employed as HTMs for low-temperature processed PSCs...
September 5, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28868561/aqueous-solution-processable-metal-oxides-for-high-performance-organic-and-perovskite-solar-cells
#9
Yan-Hui Lou, Zhao-Kui Wang
Poly(3,4-ethylene dioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) is a widely utilized hole-transporting material (HTM) in planar photovoltaic devices, such as organic solar cells (OSCs) and perovskite solar cells (PSCs). However, the hygroscopic nature of PEDOT:PSS aqueous dispersions may restrict their future application. Therefore, it is necessary to develop other effective and stable HTMs to achieve high-performance photovoltaic devices. Herein, we demonstrate a facile route to deposit solution-processed MoO3, GeO2, V2O5 and CrO3 thin films as hole-transporting layers by directly dissolving their commercial powders in deionized water...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28861951/encapsulation-of-hydrophilic-and-hydrophobic-peptides-into-hollow-mesoporous-silica-nanoparticles-for-enhancement-of-antitumor-immune-response
#10
Jun Xie, Chaohua Yang, Qianqian Liu, Jun Li, Ruijing Liang, Chen Shen, Yi Zhang, Ke Wang, Liping Liu, Khurram Shezad, Martin Sullivan, Yong Xu, Guanxin Shen, Juan Tao, Jintao Zhu, Zhiping Zhang
Codelivery of combinational antigenic peptides and adjuvant to antigen presenting cells is expected to amplify tumor specific T lymphocytes immune responses while minimizing the possibility of tumor escaping and reducing immune tolerance to single antigenic peptide. However, the varied hydrophobicities of these multivariant derived short antigenic peptides limit their codelivery efficiency in conventional delivery systems. Here, a facile yet effective route is presented to generate monodisperse and stable hollow mesoporous silica nanoparticles (HMSNs) for codelivering of HGP10025-33 and TRP2180-188 , two melanoma-derived peptides with varied hydrophobicities...
September 1, 2017: Small
https://www.readbyqxmd.com/read/28860021/disruption-of-fibronectin-matrix-affects-type-iv-collagen-fibrillin-and-laminin-deposition-into-extracellular-matrix-of-human-trabecular-meshwork-htm-cells
#11
Mark S Filla, Kaylee D Dimeo, Tiegang Tong, Donna M Peters
Fibronectin fibrils are a major component of the extracellular matrix (ECM) of the trabecular meshwork (TM). They are a key mediator of the formation of the ECM which controls aqueous humor outflow and contributes to the pathogenesis of glaucoma. The purpose of this work was to determine if a fibronectin-binding peptide called FUD, derived from the Streptococcus pyogenes Functional Upstream Domain of the F1 adhesin protein, could be used to control fibronectin fibrillogenesis and hence ECM formation under conditions where its expression was induced by treatment with the glucocorticoid dexamethasone...
August 30, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28830355/the-porcine-translational-research-database-a-manually-curated-genomics-and-proteomics-based-research-resource
#12
Harry D Dawson, Celine Chen, Brady Gaynor, Jonathan Shao, Joseph F Urban
BACKGROUND: The use of swine in biomedical research has increased dramatically in the last decade. Diverse genomic- and proteomic databases have been developed to facilitate research using human and rodent models. Current porcine gene databases, however, lack the robust annotation to study pig models that are relevant to human studies and for comparative evaluation with rodent models. Furthermore, they contain a significant number of errors due to their primary reliance on machine-based annotation...
August 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28812350/green-solvent-processable-dopant-free-hole-transporting-materials-for-robust-and-efficient-perovskite-solar-cells
#13
Junwoo Lee, Mahdi Malekshahi Byranvand, Gyeongho Kang, Sung Y Son, Seulki Song, Guan-Woo Kim, Taiho Park
In addition to having proper energy levels and high hole mobility (μh) without the use of dopants, hole-transporting materials (HTMs) used in n-i-p-type perovskite solar cells (PSCs) should be processed using green solvents to enable environmentally friendly device fabrication. Although many HTMs have been assessed, due to the limited solubility of HTMs in green solvents, no green-solvent-processable HTM has been reported to date. Here, we report on a green-solvent-processable HTM, an asymmetric D-A polymer (asy-PBTBDT) that exhibits superior solubility even in the green solvent, 2-methylanisole, which is a known food additive...
August 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28811926/postinjection-delirium-sedation-syndrome-in-patients-with-schizophrenia-receiving-olanzapine-long-acting-injection-results-from-a-large-observational-study
#14
Kristin J Meyers, Himanshu P Upadhyaya, John L Landry, Rashna Chhabra-Khanna, Deborah M Falk, Balasubramanya Seetharama Rao, Meghan E Jones
BACKGROUND: Postinjection delirium/sedation syndrome (PDSS) has been reported uncommonly during treatment with olanzapine long-acting injection (LAI), a sustained-release formulation of olanzapine. AIMS: The primary aim of the study was to estimate the incidence per injection and per patient of PDSS events in adult patients with schizophrenia who were receiving olanzapine LAI in real-world clinical practice. Secondary aims were to further characterise the clinical presentation of PDSS events, to identify potential risk factors associated with PDSS events and to characterise hospitalisations at baseline and post-baseline...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28801088/characteristics-of-severe-asthma-with-fungal-sensitization
#15
Katsunori Masaki, Koichi Fukunaga, Masako Matsusaka, Hiroki Kabata, Takae Tanosaki, Takao Mochimaru, Takashi Kamatani, Kengo Ohtsuka, Rie Baba, Soichiro Ueda, Yusuke Suzuki, Fumio Sakamaki, Yoshitaka Oyamada, Takashi Inoue, Tsuyoshi Oguma, Koichi Sayama, Hidefumi Koh, Morio Nakamura, Akira Umeda, Katsuhiko Kamei, Kenji Izuhara, Koichiro Asano, Tomoko Betsuyaku
BACKGROUND: Some patients with severe asthma also have fungal sensitization and are considered to have severe asthma with fungal sensitization. However, there is limited information on the clinical features of SAFS. OBJECTIVE: To investigate the clinical characteristics of severe asthma with fungal sensitization. METHODS: The present study enrolled 124 patients with severe asthma. We evaluated clinical aspects, such as various serum cytokines, fractional exhaled nitric oxide, pulmonary function, and serum immunoglobulin E (IgE)...
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28798387/spiro-phenylpyrazole-fluorene-as-hole-transporting-material-for-perovskite-solar-cells
#16
Yang Wang, Tzu-Sen Su, Han-Yan Tsai, Tzu-Chien Wei, Yun Chi
Spiro-OMeTAD with symmetric spiro-bifluorene unit has dominated the investigation of hole-transporting material (HTM) for efficient perovskite solar cells (PSCs) despite of its low intrinsic hole conductivity and instability. In this study, we designed and synthesized three asymmetric spiro-phenylpyrazole/fluorene base HTMs, namely: WY-1, WY-2 and WY-3. They exhibit excellent electrochemical properties and hole conductivities. Moreover, the PSC based on WY-1 exhibits the highest power conversion efficiency (PCE) of 14...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28767245/direct-observation-of-ultrafast-hole-injection-from-lead-halide-perovskite-by-differential-transient-transmission-spectroscopy
#17
Kunie Ishioka, Bobby G Barker, Masatoshi Yanagida, Yasuhiro Shirai, Kenjiro Miyano
Efficient charge separation at the interfaces of the perovskite with the carrier transport layers is crucial for perovskite solar cells to achieve high power conversion efficiency. We present a systematic experimental study on the hole injection dynamics from MAPbI3 perovskite to three typical hole transport materials (HTMs). We extract the carrier dynamics directly related to the hole injection by employing a pump light with short absorption depth and comparing the transient transmission signals excited on the two sides of the sample...
August 7, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28766075/protein-binding-hot-spots-prediction-from-sequence-only-by-a-new-ensemble-learning-method
#18
Shan-Shan Hu, Peng Chen, Bing Wang, Jinyan Li
Hot spots are interfacial core areas of binding proteins, which have been applied as targets in drug design. Experimental methods are costly in both time and expense to locate hot spot areas. Recently, in-silicon computational methods have been widely used for hot spot prediction through sequence or structure characterization. As the structural information of proteins is not always solved, and thus hot spot identification from amino acid sequences only is more useful for real-life applications. This work proposes a new sequence-based model that combines physicochemical features with the relative accessible surface area of amino acid sequences for hot spot prediction...
August 1, 2017: Amino Acids
https://www.readbyqxmd.com/read/28763501/single-stranded-adeno-associated-virus-achieves-efficient-gene-transfer-to-anterior-segment-in-the-mouse-eye
#19
Li Wang, Ru Xiao, Eva Andres-Mateos, Luk H Vandenberghe
Adeno-associated viruses (AAVs) are used extensively as a gene delivery vehicle for retinal gene therapy, yet its ability to target the anterior segment of the eye, critical to unlocking therapeutic opportunities, is less characterized. Previously, self-complimentary (sc) AAV was shown to be necessary for transduction of the cornea and trabecular meshwork (TM), limiting the size of the gene transfer cassette, likely due to a block in second strand synthesis thought to be required for functional transduction...
2017: PloS One
https://www.readbyqxmd.com/read/28756742/pentablock-copolymer-dexamethasone-nanoformulations-elevate-myoc-in-vitro-liberation-activity-and-safety-in-human-trabecular-meshwork-cells
#20
Vibhuti Agrahari, Guorong Li, Vivek Agrahari, Iris Navarro, Kristin Perkumas, Abhirup Mandal, W Daniel Stamer, Ashim K Mitra
AIM: The aim of this study is to examine the elevation of MYOC in long-term treatment of human trabecular meshwork (HTM) cells using dexamethasone (DEX) encapsulated pentablock (PB) copolymer-based nanoparticles (NPs) (DEX-PB-NPs). MATERIALS & METHODS: PB copolymers and DEX-PB-NPs were synthesized and characterized using nuclear magnetic resonance, gel permeation chromatography, and X-ray diffraction analyses. MYOC levels secreted from HTM cells were measured by western blot (WB) analysis...
August 2017: Nanomedicine
keyword
keyword
42139
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"