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https://www.readbyqxmd.com/read/27919703/prediction-and-mechanism-elucidation-of-analyte-retention-on-phospholipid-stationary-phases-iam-hplc-by-in-silico-calculated-physico-chemical-descriptors
#1
Giacomo Russo, Lucia Grumetto, Francesco Barbato, Giulio Vistoli, Alessandro Pedretti
The present study proposes a method for an in silico calculation of phospholipophilicity. Phospholipophilicity is intended as the measure of analyte affinity for phospholipids; it is currently assessed by HPLC measures of analyte retention on phosphatidylcholine-like stationary phases (IAM - Immobilized Artificial Membrane) resulting in log kW(IAM) values. Due to the amphipathic and electrically charged nature of phospholipids, retention on these stationary phases results from complex mechanisms, being affected not only by lipophilicity (as measured by n-octanol/aqueous phase partition coefficients, log P) but also by the occurrence of polar and/or electrostatic intermolecular interaction forces...
December 2, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27909158/off-site-emergency-planning-at-uk-nuclear-licensed-sites
#2
Paul Leonard, Gareth Thomas
Nuclear emergency planning arrangements in the UK are continually kept under review. This work proposes to outline how experience from nuclear exercises and undertaking emergency response duties can be based on radiological knowledge of specific sites and utilised in the future. In 2014, the UK regulator, the Office for Nuclear Regulation (ONR) revised their principles for the determination of off-site emergency planning areas around nuclear sites where predetermined countermeasures and other protection measures are applied to protect those people who may be affected by a radiation emergency...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27891553/core-curriculum-illustration-dural-venous-sinus-thrombosis
#3
Sibi Rajendran, Alex Pereira, Morgan Eckerd, Barbara Pawley
This is the 25th installment of a series that will highlight one case per publication issue from the bank of cases available online as a part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for study online at http://www.aseronline.org/curriculum/toc.htm .
November 28, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27882554/study-of-heat-moisture-treatment-of-potato-starch-granules-by-chemical-surface-gelatinization
#4
Josiane Bartz, Elessandra da Rosa Zavareze, Alvaro Renato Guerra Dias
BACKGROUND: Native potato starch was heat-moisture treated (HMT) at 12, 15, 18, 21 and 24 % of moisture content at 110 °C for 1 h and the effects on morphology, structure, thermal and physicochemical properties were investigated. To reveal the internal structure, 30 and 50 % of the granular surface were removed by chemical surface gelatinization in concentrated LiCl solution. RESULTS: At moisture contents of 12 and 15 %, the HTM reduced the gelatinization temperatures and relative crystallinity of the starches while at moisture contents of 21 and 24 % both increased...
November 23, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27878244/microrna%C3%A2-93-is-overexpressed-and-induces-apoptosis-in-glaucoma-trabecular-meshwork-cells
#5
Yansa Wang, Fenghua Li, Shuyun Wang
Glaucoma is an optic neuropathy and a major cause of blindness globally. Trabecular meshwork cells are important in maintaining aqueous humor flow, the dysfunction of which tends to induce glaucoma. As important regulators of gene expression, microRNAs may be crucial in regulating trabecular meshwork cells. The present study aimed to reveal the effect of microRNA‑93 (miR‑93) on glaucoma trabecular meshwork (GTM) cell apoptosis. The expression levels of miR‑93 were compared between human trabecular meshwork (HTM) cells and GTM cells...
November 14, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27865182/early-initiation-of-eicosapentaenoic-acid-and-statin-treatment-is-associated-with-better-clinical-outcomes-than-statin-alone-in-patients-with-acute-coronary-syndromes-1-year-outcomes-of-a-randomized-controlled-study
#6
Kazumasa Nosaka, Toru Miyoshi, Mutsumi Iwamoto, Masahito Kajiya, Keisuke Okawa, Saori Tsukuda, Fumi Yokohama, Masahiro Sogo, Tomoyuki Nishibe, Naoaki Matsuo, Satoshi Hirohata, Hiroshi Ito, Masayuki Doi
BACKGROUND: Early initiation of EPA treatment in combination with a statin within 24h after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (MI) reduces inflammation and ventricular arrhythmia compared with statin monotherapy; however, the impact of early initiation of EPA treatment on cardiovascular events is unclear. We determined whether early eicosapentaenoic acid (EPA) treatment in patients with acute coronary syndrome (ACS) reduces adverse cardiovascular events...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27835865/il-15-enhances-the-anti-tumor-activity-of-trastuzumab-against-breast-cancer-cells-but-causes-fatal-side-effects-in-humanized-tumor-mice-htm
#7
Anja K Wege, Florian Weber, Alexander Kroemer, Olaf Ortmann, Falk Nimmerjahn, Gero Brockhoff
Cancer immunotherapy has been shown to enhance established treatment regimens. We evaluated the potential reinforcing effect of IL-15 in trastuzumab treated humanized tumor mice (HTM) which were generated by concurrent transplantation of neonatal NOD-scid IL2Rγnull mice with human hematopoietic stem cells (HSC) and HER2 positive breast cancer cells (metastasizing SK-BR-3, solid tumor forming BT474). We found that trastuzumab treatment efficacy mainly depends on the immediate anti-tumorigenic cellular effect which is significantly enhanced by tumor interacting immune cells upon cotransplantion of HSC...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27827517/using-robot-fully-assisted-functional-movements-in-upper-limb-rehabilitation-of-chronic-stroke-patients-preliminary-results
#8
Marco Caimmi, Andrea Chiavenna, Alessandro Scano, Giulio Gasperini, Chiara Giovanzana, Lorenzo Molinari Tosatti, Franco Molteni
BACKGROUND: Robotic rehabilitation is promising to promote function in stroke patients. The assist as needed training paradigm has shown to stimulate neuroplasticity but often cannot be used because stroke patients are too impaired to actively control the robot against gravity. AIM: To verify whether a rehabilitation intervention based on robot fully assisted Reaching against gravity (RCH) and Hand-to-Mouth (HTM) can promote upper-limb function in chronic stroke...
November 9, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27814681/wuflux-an-open-source-platform-for-13-c-metabolic-flux-analysis-of-bacterial-metabolism
#9
Lian He, Stephen G Wu, Muhan Zhang, Yixin Chen, Yinjie J Tang
BACKGROUND: Flux analyses, including flux balance analysis (FBA) and (13)C-metabolic flux analysis ((13)C-MFA), offer direct insights into cell metabolism, and have been widely used to characterize model and non-model microbial species. Nonetheless, constructing the (13)C-MFA model and performing flux calculation are demanding for new learners, because they require knowledge of metabolic networks, carbon transitions, and computer programming. To facilitate and standardize the (13)C-MFA modeling work, we set out to publish a user-friendly and programming-free platform (WUFlux) for flux calculations in MATLAB(®)...
November 4, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27803851/effects-of-dexamethasone-and-ha1077-on-actin-cytoskeleton-and-%C3%AE-catenin-in-cultured-human-trabecular-meshwork-cells
#10
Jie Peng, Xiao-Yun Feng, Zi-Meng Ye, Qian Luo, Yi-Lian Cheng, Zheng-Zheng Wu, Chun-Tao Lei, Bo Gong
AIM: To investigate the effects of dexamethasone (DEX) and 1-(5-isoquinolinesulfonyl)-homopiperazine (HA1077) on actin cytoskeleton and β-catenin in cultured human trabecular meshwork (HTM) cells. METHODS: The HTM cells were separated from human eyeball and cultured in vitro. They were divided into control group, DEX (1×10(-6) mol/L) group, HA1077 (3×10(-5) mol/L) group, and DEX (1×10(-6) mol/L) and HA1077 (3×10(-5) mol/L) group. Actin cytoskeleton and β-catenin in HTM cells of the four groups were examined by immunofluorescence and Western blot analyses...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27791344/near-infrared-absorbing-and-dopant-free-heterocyclic-quinoid-based-hole-transporting-materials-for-efficient-perovskite-solar-cells
#11
Jen-Shyang Ni, Hsiao-Chi Hsieh, Chun-An Chen, Yuh-Sheng Wen, Wen-Ti Wu, Yen-Chen Shih, King-Fu Lin, Leeyih Wang, Jiann T Lin
New heterocyclic quinoid-based hole transporting materials (HTMs) with a rigid quinoid core [3,6-di(2H-imidazol-2-ylidene)cyclohexa-1,4-diene] have been synthesized. The new HTMs have good hole mobility (>10(-4)  cm(2)  V(-1)  s(-1) ) and very intense absorption in the near-infrared region extending to >800 nm. High performance perovskite solar cells can be fabricated using these HTMs without dopant. The best cell efficiency under simulated AM 1.5 G illumination reaches 12.22 %, which is comparable with that (12...
November 23, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27788310/increasing-versus-maintaining-the-dose-of-olanzapine-or-risperidone-in-schizophrenia-patients-who-did-not-respond-to-a-modest-dosage-a-double-blind-randomized-controlled-trial
#12
Hitoshi Sakurai, Takefumi Suzuki, Robert R Bies, Bruce G Pollock, Masaru Mimura, Shitij Kapur, Hiroyuki Uchida
OBJECTIVE: While doctors often increase the dose of an antipsychotic when there is insufficient response, there is limited evidence that this intervention is any better than waiting longer on the lower dose. We put the proposition to test. METHOD: In this 4-week, double-blind, randomized controlled trial conducted in psychiatric care from September 2012 to March 2015, 103 patients with schizophrenia (ICD-10) who did not respond to olanzapine 10 mg/d or risperidone 3 mg/d were randomly allocated to a dose-increment or -continuation group...
October 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27785614/core-curriculum-illustration-rib-fractures
#13
Gregor M Dunham, Alexandre Perez-Girbes, Ken F Linnau
This is the 24th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.aseronline.org/curriculum/toc.htm .
October 26, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27778114/aser-core-curriculum-illustration-project-aortic-intramural-hematoma-imh
#14
Alexandre Perez-Girbes, Gregor M Dunham, Ken F Linnau
This is the installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.aseronline.org/curriculum/toc.htm .
October 24, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27757729/core-curriculum-illustration-blunt-trauma-to-the-bowel
#15
Nupur Verma, John D Pham, Ken F Linnau
This is the 22nd installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.aseronline.org/curriculum/toc.htm .
October 18, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27741311/impact-of-the-choice-of-normalization-method-on-molecular-cancer-class-discovery-using-nonnegative-matrix-factorization
#16
Haixuan Yang, Cathal Seoighe
Nonnegative Matrix Factorization (NMF) has proved to be an effective method for unsupervised clustering analysis of gene expression data. By the nonnegativity constraint, NMF provides a decomposition of the data matrix into two matrices that have been used for clustering analysis. However, the decomposition is not unique. This allows different clustering results to be obtained, resulting in different interpretations of the decomposition. To alleviate this problem, some existing methods directly enforce uniqueness to some extent by adding regularization terms in the NMF objective function...
2016: PloS One
https://www.readbyqxmd.com/read/27739653/hole-transport-materials-for-perovskite-solar-cells
#17
REVIEW
Laura Calió, Samrana Kazim, Michael Grätzel, Shahzada Ahmad
The pressure to move towards renewable energy has inspired researchers to look for ideas in photovoltaics that may lead to a major breakthrough. Recently the use of perovskites as a light harvester has lead to stunning progress. The power conversion efficiency of perovskite solar cells is now approaching parity (>22 %) with that of the established technology which took decades to reach this level of performance. The use of a hole transport material (HTM) remains indispensable in perovskite solar cells...
November 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27739309/colloidal-precursor-induced-growth-of-ultra-even-ch3nh3pbi3-for-high-performance-paintable-carbon-based-perovskite-solar-cells
#18
Xiaowen Chang, Weiping Li, Haining Chen, Liqun Zhu, Huicong Liu, Huifang Geng, Sisi Xiang, Jiaming Liu, Xiaoli Zheng, Ying-Long Yang, Shihe Yang
Carbon-based hole transport materials (HTM)-free perovskite solar cells (PSCs) due to their relatively high stability have attracted intense attention. However, their power conversion efficiency (PCE) is still low, especially for the simplest paintable carbon-based PSCs (C-PSCs), whose performance is greatly limited by the poor contact at perovskite/carbon interface. To enhance interface contact, it is important to fabricate an even-surface perovskite layer in porous scaffold, which is usually unfeasible due to rough crystal precursor...
October 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27723319/protein-dynamics-and-contact-topology-reveal-protein-dna-binding-orientation
#19
Aravind Chandrasekaran, Justin Chan, Carmay Lim, Lee-Wei Yang
Structure-encoded conformational dynamics are crucial for biomolecular functions. However, there is insufficient evidence to support the notion that dynamics plays a role in guiding protein-nucleic acid interactions. Here, we show that protein-DNA docking orientation is a function of protein intrinsic dynamics but the binding site itself does not display unique patterns in the examined spectrum of motions. This revelation is made possible by a novel technique that locates 'dynamics interfaces' in proteins across which protein parts are anti-correlated in their slowest dynamics...
October 10, 2016: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/27718567/pbi2-hmpa-complex-pretreatment-for-highly-reproducible-and-ef-ficient-ch3nh3pbi3-perovskite-solar-cells
#20
Yi Zhang, Peng Gao, Emad Oveisi, Yonghui Lee, Quentin Jeangros, Giulia Grancini, Sanghyun Paek, Yaqing Feng, Mohammad Khaja Nazeeruddin
Interfacial engineering of the meso-TiO2 surface through a modified sequential deposition procedure involving a novel PbI2-HMPA complex pretreatment is conducted as a reproducible method for preparing MAPbI3-based perovskite solar cells providing the highest efficiencies yet reported with polymer HTM layer. Grazing incidence X-ray diffraction depth profiling confirms the formation of a perovskite film with PbI2-rich region close to the electron transport layer (ETL) due to the strong interaction of HMPA with PbI2, which successfully retarded the dissolution of PbI2 phase when depositing the perovskite layer on top...
October 10, 2016: Journal of the American Chemical Society
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