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https://www.readbyqxmd.com/read/28801088/characteristics-of-severe-asthma-with-fungal-sensitization
#1
Katsunori Masaki, Koichi Fukunaga, Masako Matsusaka, Hiroki Kabata, Takae Tanosaki, Takao Mochimaru, Takashi Kamatani, Kengo Ohtsuka, Rie Baba, Soichiro Ueda, Yusuke Suzuki, Fumio Sakamaki, Yoshitaka Oyamada, Takashi Inoue, Tsuyoshi Oguma, Koichi Sayama, Hidefumi Koh, Morio Nakamura, Akira Umeda, Katsuhiko Kamei, Kenji Izuhara, Koichiro Asano, Tomoko Betsuyaku
BACKGROUND: Some patients with severe asthma also have fungal sensitization and are considered to have severe asthma with fungal sensitization. However, there is limited information on the clinical features of SAFS. OBJECTIVE: To investigate the clinical characteristics of severe asthma with fungal sensitization. METHODS: The present study enrolled 124 patients with severe asthma. We evaluated clinical aspects, such as various serum cytokines, fractional exhaled nitric oxide, pulmonary function, and serum immunoglobulin E (IgE)...
August 8, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28798387/spiro-phenylpyrazole-fluorene-as-hole-transporting-material-for-perovskite-solar-cells
#2
Yang Wang, Tzu-Sen Su, Han-Yan Tsai, Tzu-Chien Wei, Yun Chi
Spiro-OMeTAD with symmetric spiro-bifluorene unit has dominated the investigation of hole-transporting material (HTM) for efficient perovskite solar cells (PSCs) despite of its low intrinsic hole conductivity and instability. In this study, we designed and synthesized three asymmetric spiro-phenylpyrazole/fluorene base HTMs, namely: WY-1, WY-2 and WY-3. They exhibit excellent electrochemical properties and hole conductivities. Moreover, the PSC based on WY-1 exhibits the highest power conversion efficiency (PCE) of 14...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28767245/direct-observation-of-ultrafast-hole-injection-from-lead-halide-perovskite-by-differential-transient-transmission-spectroscopy
#3
Kunie Ishioka, Bobby G Barker, Masatoshi Yanagida, Yasuhiro Shirai, Kenjiro Miyano
Efficient charge separation at the interfaces of the perovskite with the carrier transport layers is crucial for perovskite solar cells to achieve high power conversion efficiency. We present a systematic experimental study on the hole injection dynamics from MAPbI3 perovskite to three typical hole transport materials (HTMs). We extract the carrier dynamics directly related to the hole injection by employing a pump light with short absorption depth and comparing the transient transmission signals excited on the two sides of the sample...
August 7, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28766075/protein-binding-hot-spots-prediction-from-sequence-only-by-a-new-ensemble-learning-method
#4
Shan-Shan Hu, Peng Chen, Bing Wang, Jinyan Li
Hot spots are interfacial core areas of binding proteins, which have been applied as targets in drug design. Experimental methods are costly in both time and expense to locate hot spot areas. Recently, in-silicon computational methods have been widely used for hot spot prediction through sequence or structure characterization. As the structural information of proteins is not always solved, and thus hot spot identification from amino acid sequences only is more useful for real-life applications. This work proposes a new sequence-based model that combines physicochemical features with the relative accessible surface area of amino acid sequences for hot spot prediction...
August 1, 2017: Amino Acids
https://www.readbyqxmd.com/read/28763501/single-stranded-adeno-associated-virus-achieves-efficient-gene-transfer-to-anterior-segment-in-the-mouse-eye
#5
Li Wang, Ru Xiao, Eva Andres-Mateos, Luk H Vandenberghe
Adeno-associated viruses (AAVs) are used extensively as a gene delivery vehicle for retinal gene therapy, yet its ability to target the anterior segment of the eye, critical to unlocking therapeutic opportunities, is less characterized. Previously, self-complimentary (sc) AAV was shown to be necessary for transduction of the cornea and trabecular meshwork (TM), limiting the size of the gene transfer cassette, likely due to a block in second strand synthesis thought to be required for functional transduction...
2017: PloS One
https://www.readbyqxmd.com/read/28756742/pentablock-copolymer-dexamethasone-nanoformulations-elevate-myoc-in-vitro-liberation-activity-and-safety-in-human-trabecular-meshwork-cells
#6
Vibhuti Agrahari, Guorong Li, Vivek Agrahari, Iris Navarro, Kristin Perkumas, Abhirup Mandal, W Daniel Stamer, Ashim K Mitra
AIM: The aim of this study is to examine the elevation of MYOC in long-term treatment of human trabecular meshwork (HTM) cells using dexamethasone (DEX) encapsulated pentablock (PB) copolymer-based nanoparticles (NPs) (DEX-PB-NPs). MATERIALS & METHODS: PB copolymers and DEX-PB-NPs were synthesized and characterized using nuclear magnetic resonance, gel permeation chromatography, and X-ray diffraction analyses. MYOC levels secreted from HTM cells were measured by western blot (WB) analysis...
August 2017: Nanomedicine
https://www.readbyqxmd.com/read/28749213/htm-departments-should-operate-like-a-business
#7
Ted Cohen
No abstract text is available yet for this article.
July 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28741751/assessment-of-diastolic-function-of-normal-fetal-heart-using-the-dual-gate-doppler-method
#8
Mayumi Takano, Masahiko Nakata, Sumito Nagasaki, Rei Ueyama, Mineto Morita
OBJECTIVES: The ratio of mitral peak early diastolic filling to early diastolic mitral annular velocity (E/e') reflects diastolic cardiac function in adults. The Dual gate Doppler (DD) method enables measurements of E/e' in the same heartbeat. This study was designed to assess the utility of the DD method for measurement of fetal E/e', and to determine reference ranges for normal fetuses. METHODS: This prospective study comprised normal singleton pregnancies between 16 and 36 weeks of gestational age (GA)...
July 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28733664/charge-injection-carriers-recombination-and-homo-energy-level-relationship-in-perovskite-solar-cells
#9
Jesús Jiménez-López, Werther Cambarau, Lydia Cabau, Emilio Palomares
We present a comparative study between a series of well-known semiconductor polymers, used in efficient organic solar cells as hole transport materials (HTM), and the state-of-the art material used as hole transport material in perovskite solar cells: the spiro-OMeTAD. The observed differences in solar cell efficiencies are studied in depth using advanced photoinduced spectroscopic techniques under working illumination conditions. We have observed that there is no correlation between the highest occupied molecular orbital (HOMO) energy levels of the organic semiconductors and the measured open-circuit voltage (VOC)...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727425/the-database-and-bioinformatics-studies-of-probiotics
#10
Lin Tao, Bohua Wang, Yafen Zhong, Siok Hoon Pow, Xian Zeng, Chu Qin, Peng Zhang, Shangying Chen, Weidong He, Ying Tan, Hongxia Liu, Yuyang Jiang, Weiping Chen, Yu Zong Chen
Probiotics have been widely explored for health benefits, animal cares, and agricultural applications. Recent advances in microbiome, microbiota and microbial dark matter research have fueled greater interests in and paved ways for the study of the mechanisms of probiotics and the discovery of new probiotics from uncharacterized microbial sources. A probiotics database named PROBIO was developed to facilitate these efforts and the need for the information of the known probiotics, which provides the comprehensive information about the probiotic functions of 448 marketed, 167 clinical trial/field trial and 382 research probiotics for use or being studied for use in humans, animals, and plants...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28696442/reducing-hole-transporter-use-and-increasing-perovskite-solar-cell-stability-with-dual-role-polystyrene-microgel-particles
#11
Mu Chen, Muhamad Z Mokhtar, Eric Whittaker, Qing Lian, Bruce Hamilton, Paul O'Brien, Mingning Zhu, Zhengxing Cui, Saif A Haque, Brian R Saunders
Perovskite solar cells (PSCs) are a disruptive technology that continues to attract considerable attention due to their remarkable and sustained power conversion efficiency increase. Improving PSC stability and reducing expensive hole transport material (HTM) usage are two aspects that are gaining increased attention. In a new approach, we investigate the ability of insulating polystyrene microgel particles (MGs) to increase PSC stability and replace the majority of the HTM phase. MGs are sub-micrometre crosslinked polymer particles that swell in a good solvent...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28687341/carbenoxolone-prevents-chemical-eye-ischemia-reperfusion-induced-cell-death-via-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibition
#12
Kyoung-Jin Choi, Yoon-Ju Na, Sung Bum Park, Won Hoon Jung, Hye-Rim Sung, Ki Young Kim
Glaucoma is one of the leading causes of preventable blindness diseases, affecting more than 2 million people in the United States. Recently, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors were found to exert preventive effects against glaucoma. Therefore, we investigated whether carbenoxolone (CBX), an 11β-HSD1 inhibitor, prevents chemical ischemia-reperfusion-induced cell death in human trabecular meshwork (HTM) cells. The present study demonstrated that CBX inhibited cell death caused by iodoacetic acid (IAA)-induced ischemia-reperfusion, and its effect was associated with the inhibition of 11β-HSD1 expression and activity...
July 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28684643/clarithromycin-plus-intravenous-immunoglobulin-therapy-can-reduce-the-relapse-rate-of-kawasaki-disease-a-phase-2-open-label-randomized-control-study
#13
Etsuro Nanishi, Hisanori Nishio, Hidetoshi Takada, Kenichiro Yamamura, Mitsuharu Fukazawa, Kenji Furuno, Yumi Mizuno, Kenjiro Saigo, Ryo Kadoya, Noriko Ohbuchi, Yasuhiro Onoe, Hironori Yamashita, Hideki Nakayama, Takuya Hara, Takuro Ohno, Yasuhiko Takahashi, Ken Hatae, Tatsuo Harada, Takayuki Shimose, Junji Kishimoto, Shouichi Ohga, Toshiro Hara
BACKGROUND: We previously reported that biofilms and innate immunity contribute to the pathogenesis of Kawasaki disease. Therefore, we aimed to assess the efficacy of clarithromycin, an antibiofilm agent, in patients with Kawasaki disease. METHODS AND RESULTS: We conducted an open-label, multicenter, randomized, phase 2 trial at 8 hospitals in Japan. Eligible patients included children aged between 4 months and 5 years who were enrolled between days 4 and 8 of illness...
July 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28673001/role-of-nuclear-factor-erythroid-derived-2-like-2-in-the-age-resistant-properties-of-the-glaucoma-trabecular-meshwork
#14
Jintao Cheng, Jiamei Liang, Jinze Qi
Glaucoma is a major cause of irreversible blindness. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates the expression of numerous antioxidants within cells and is therefore a focus of current ophthalmic research. To determine the roles of Nrf2 in mediating the glaucoma trabecular meshwork (GTM), the present study evaluated the levels of Nrf2 expression in GTM and human trabecular meshwork (HTM) cells by reverse-transcription-quantitative polymerase chain reaction and western blot analysis. It was principally observed that Nrf2 expression was downregulated in GTM cells...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28671835/rational-design-of-molecular-hole-transporting-materials-for-perovskite-solar-cells-direct-versus-inverted-device-configurations
#15
Roberto Grisorio, Rosabianca Iacobellis, Andrea Listorti, Luisa De Marco, Maria Pia Cipolla, Michele Manca, Aurora Rizzo, Antonio Abate, Giuseppe Gigli, Gian Paolo Suranna
Due to a still limited understanding of the reasons making 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenylamine)-9,9'-spirobifluorene (Spiro-OMeTAD) the state-of-the-art hole-transporting material (HTM) for emerging photovoltaic applications, the molecular tailoring of organic components for perovskite solar cells (PSCs) lacks in solid design criteria. Charge delocalization in radical cationic states can undoubtedly be considered as one of the essential prerequisites for an HTM, but this aspect has been investigated to a relatively minor extent...
July 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28664952/quantifying-ultrafast-charge-carrier-injection-from-methylammonium-lead-iodide-into-the-hole-transport-material-h101-and-mesoporous-tio2-using-vis-nir-transient-absorption
#16
Johannes R Klein, Mirko Scholz, Kawon Oum, Thomas Lenzer
Organic-inorganic hybrid lead halide perovskites already reach very high power conversion efficiencies above 22% on architectures employing mesoporous TiO2, but the carrier injection processes across the different interfaces are still not fully understood. Here we use ultrafast broadband transient absorption spectroscopy to determine time constants and yields for hole and electron injection. We show that hole transfer from the perovskite valence band (VB) to the hole-transport material (HTM) H101 at the perovskite/HTM interface occurs in less than 500 fs, but is limited by imperfections of the contact layer and poor infiltration of the HTM into the mesoporous structure...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28653432/low-cost-carbazole-based-hole-transport-material-for-highly-efficient-perovskite-solar-cells
#17
Zhiliang Chen, Hui Li, Xiaolu Zheng, Qi Zhang, Zhanfeng Li, Yuying Hao, Guojia Fang
A low-cost carbazole-based small-molecule material, 1,3,6,8-tetra(N,N-p-dimethoxyphenylamino)-9-ethylcarbazole, was designed and synthesized through a facile three-step synthetic route. The material was characterized and applied as a hole-transport material (HTM) for low-temperature-processed planar perovskite solar cells (PSCs). Devices based on this new HTM exhibit a high power-conversion efficiency of 17.8 % that is comparable to that of PSCs based on the costly 2,2',7,7'-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9'-spirobifluorene (Spiro-OMeTAD) (18...
June 26, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28650097/low-cost-perovskite-solar-cells-employing-dimethoxydiphenylamine-substituted-bistricyclic-aromatic-enes-as-hole-transport-materials
#18
Kasparas Rakstys, Sanghyun Paek, Giulia Grancini, Peng Gao, Vygintas Jankauskas, Abdullah M Asiri, Mohammad Khaja Nazeeruddin
The synthesis, characterization and photovoltaic performance of series of novel molecular hole transport materials (HTMs) based on bistricyclic aromatic enes (BAEs) are presented. The new derivatives were obtained following a simple and straightforward procedure from inexpensive starting reagents mimicking the synthetically challenging 9,9'-spirobifluorene moiety of the well-studied spiro-OMeTAD. The novel HTMs were tested in mixed cations and anions perovskite solar cells (PSCs) yielding a power conversion efficiency (PCE) of 19...
June 26, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28636771/is-transvaginal-contained-tissue-extraction-for-everyone
#19
Charles Miller
Professor Ghezzi, et al. should be congratulated for their excellent manuscript "Transvaginal Contained Tissue Extraction After Laparoscopic Myomectomy: A Cohort Study". This is a well-conceived, well-written retrospective cohort study describing operative and peri-operative outcomes for patients who have undergone transvaginal morcellation via a posterior colpotomy. Given the continued controversy regarding electronic power morcellation leading to restriction of use in certain areas, this study is not only impactful, in that it describes an alternative technique with data accumulated over a decade of experience, but it describes a technique of contained morcellation that is neither based on the controversial power morcellation, nor the mini-laparotomy (https://www...
June 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28625600/where-to-do-water-testing-for-pseudomonas-aeruginosa-in-a-healthcare-setting
#20
Mark I Garvey, Craig W Bradley, Elisabeth Holden, Mike Weibren
Pseudomonas aeruginosa is an important nosocomial pathogen commonly colonising hospital water supplies. HTM 04-01 addresses the risk posed by recommending water testing in augmented care areas which includes outpatient haemodialysis. We discuss how two teaching hospitals independently reviewed the risk to outpatient haemodialysis patients drawing the same conclusion. The highest number of infection episodes with P. aeruginosa was seen in critical care followed by burns and haematology with the lowest in haemodialysis...
June 15, 2017: Journal of Hospital Infection
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