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Cristina Rodríguez-Seco, Lydia Cabau, Anton Vidal-Ferran, Emilio Palomares
Over hundreds of new organic semiconductor molecules have been synthesized as hole transport materials (HTMs) for perovskite solar cells. However, to date, the well-known N2 , N2 , N2' , N2' , N7 , N7 , N7' , octakis-(4-methoxyphenyl)-9,9-spirobi-[9,9'-spirobi[9 H-fluorene]-2,2',7,7'-tetramine (spiro-OMeTAD) is still the best choice for the best perovskite device performance. Nevertheless, there is a consensus that spiro-OMeTAD by itself is not stable enough for long-term stable devices, and its market price makes its use in large-scale production costly...
March 15, 2018: Accounts of Chemical Research
Jayendra M Bhalodiya, Arnab Palit, Manoj K Tiwari, Sanjay K Prasad, Sunil K Bhudia, Theodoros N Arvanitis, Mark A Williams
Cardiovascular disease diagnosis and prognosis can be improved by measuring patient-specific in-vivo local myocardial strain using Magnetic Resonance Imaging. Local myocardial strain can be determined by tracking the movement of sample muscles points during cardiac cycle using cardiac motion estimation model. The tracking accuracy of the benchmark Free Form Deformation (FFD) model is greatly affected due to its dependency on tunable parameters and regularisation function. Therefore, Hierarchical Template Matching (HTM) model, which is independent of tunable parameters, regularisation function, and image-specific features, is proposed in this article...
March 14, 2018: Scientific Reports
Ayan Das, Prithwi Ghosh, Sampa Das
Transgenic Brassica juncea plants expressing Colocasia esculenta tuber agglutinin (CEA) shows the non-allergenic nature of the expressed protein leading to enhanced mortality and reduced fecundity of mustard aphid-Lipaphis erysimi. Lipaphis erysimi (common name: mustard aphid) is the most devastating sucking insect pest of Indian mustard (Brassica juncea L.). Colocasia esculenta tuber agglutinin (CEA), a GNA (Galanthus nivalis agglutinin)-related lectin has previously been reported by the present group to be effective against a wide array of hemipteran insects in artificial diet-based bioassays...
March 8, 2018: Plant Cell Reports
Yuichi Uchino, Masafumi Watanabe, Munenori Takata, Eisuke Amiya, Kensuke Tsushima, Takeshi Adachi, Yukio Hiroi, Toshikazu Funazaki, Issei Komuro
BACKGROUND: We conducted a randomized, controlled trial to determine whether supplementation with oral branched-chain amino acids (BCAAs) improves serum albumin and clinical outcomes in heart failure (HF) patients with hypoalbuminemia. METHODS AND RESULTS: We randomly assigned 18 in-hospital HF patients with serum albumin < 3.5 g/dL to receive oral BCAA granules (LIVACT® ) for 28 days during their hospital stay or until discharge (BCAA group; N = 9) or to receive no supplementation (controls; N = 9), in addition to recommended HF therapy...
March 6, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Ashish Kulkarni, Trilok Singh, Ajay Kumar Jena, Peerathat Pinpithak, Masashi Ikegami, Tsutomu Miyasaka
Low stability of organic-inorganic lead halide perovskite and toxicity of lead (Pb) quest for alternative non-toxic and stable light absorbing materials with promising optoelectronic properties. Herein, we report about non-toxic bismuth triiodide (BiI3) photovoltaic device prepared using TiO2 mesoporous film and spiro-OMeTAD as electron and hole transporting materials, respectively. Effect of annealing methods (e.g. thermal annealing-TA, solvent vapour annealing-SVA, pot-roast vapour annealing-PR-VA) and different annealing temperatures (90, 120, 150 and 180 OC for PR-VA) on BiI3 film morphology was investigated...
March 6, 2018: ACS Applied Materials & Interfaces
Wa Cai, Wen Ma, Guan-Tao Wang, Wei-Dong Shen
BACKGROUND: Poststroke depression is closely related to increased mortality in stroke patients. Compared with antidepressants, electroacupuncture (EA) treatment for poststroke depression (PSD) has relatively more stable effectiveness and can reduce side effects. This trial is designed to provide solid evidence for the efficacy and safety of EA treatment for patients with PSD. METHODS/DESIGN: This ongoing study is a single-blind, single-center, parallel group, randomized controlled trial...
March 2, 2018: Trials
A Ranjitha Dhanasekaran, Katheleen J Gardiner
Reverse Phase Protein Arrays (RPPA) is a high-throughput technology used to profile levels of protein expression. Handling the large datasets generated by RPPA can be facilitated by appropriate software tools. Here, we describe RPPAware, a free and intuitive software suite that was developed specifically for analysis and visualization of RPPA data. RPPAware is a portable tool that requires no installation and was built using Java. Many modules of the tool invoke R to utilize the statistical features. To demonstrate the utility of RPPAware, data generated from screening brain regions of a mouse model of Down syndrome with 62 antibodies were used as a case study...
January 15, 2018: Journal of Bioinformatics and Computational Biology
Saman Kohnehpoushi, Pariya Nazari, Bahram Abdollahi Nejand, Mehdi Eskandari
Here, the MoS2 thin film was studied as a potential 2D hole transporting materials for fabrication of low-cost, durable, and efficient perovskite solar cells. Regarding the 2D character of MoS2, its thickness was studied as a potential factor in reaching high power conversion efficiency of the perovskite solar cells. Besides, the perovskite layer thickness and the different metal back contacts showed distinct photovoltaic properties of the designed perovskite solar cells. The results presented that a single sheet of MoS2 could considerably improve the device PCE from 10...
February 23, 2018: Nanotechnology
Wu Ruibin, Xiaowei Zheng, Jiaying Chen, Xinyi Zhang, Xiayin Yang, Yuxian Lin
OBJECTIVE: This study aimed to investigate the effect and potential mechanism of miR-1298 in the progression of human trabecular meshwork (HTM) cells. MATERIAL AND METHODS: Expression of miR-1298 was assessed by quantitative real time PCR (qRT-PCR), as well as in HTM-1 and HTM-2 cells. Mature miR-1298 mimic, miR-1298 inhibitor, and si-EIF4E3 and their corresponding controls were transfected into HTM-1 and HTM-2 to obtain stable HTM cells. Luciferase reporter assay was used to verify regulation between miR-1298 and EIF4E3...
February 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Soumen Chandra, Karunamay Majee, Triveni Kumar Mahto, Sumanta Kumar Padhi, Sumanta Kumar Sahu
Anatase hierarchical TiO2 microsphere/carbon dots composite (HTM/CDs) was fabricated by a facile method for active visible light photocatalysis. The phase, morphology, microstructure and optical properties were investigated by X-ray diffraction, scanning electronmicroscopy, transmission electron microscopy and UV-VIS diffuse reflectance spectroscopy respectively. Under visible light illumination, the fabricated HTM/CDs composite was exhibited an enhanced photo catalytic activity compared to that of pure hierarchical TiO2 microspheres (HTM)...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Jiajia Xiao, Po Li, Xiaogang Wen
Novel jujube-like hierarchical TiO2 microspheres (HTM) were synthesized by an alkali corrosion process of titanium phosphate (Ti2O3(H2PO4)2·2H2O) microspheres. The hierarchical titanium phosphate microspheres (HTPM) intermediates consisting of nanoflakes with a thickness of 20 nm were prepared firstly by a facile hydrothermal method. After reacting with diluted NaOH at low temperature and atmospheric pressure,following by subsequent acid washing and calcination process, the HTPM intermediates transformed to TiO2 with well remained microsphere morphology, while the nanoflakes became porous, and some new nanowires formed between the nanoflakes...
February 15, 2018: Nanotechnology
Lijun Yang, Pan Yang, Zijun Hu, Ting Jiang, Xinchun Lai, Hong Lin, Xiaochong Zhao
The chemical doping is an effective strategy to improve the charge transport property of hole transport material (HTM). Herein, tris(2-(1H-pyrazol-1-yl)pyridine]cobalt(III) (FK102) doped 2,2,7,7-tetrakis(N, N-di-p-methoxyphenylamine)-9,9-spirobifluorene (spiro-MeOTAD) as HTM for semi-transparent cesium-containing planar perovskite solar cell (Cs0.1MA0.9PbI3) is demonstrated. Incorporating FK102 realizes efficient doping, which improves the mobility of HTM from 3.948 × 10-3 m2V-1s-1 to 2.22 × 10-2 m2V-1s-1, which is 5...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Sung-Ho Jin, Ho-Yeol Park, Saripally Sudhaker Reddy, Haeun Kwon, Jongmoon Shin, Myungkwan Song, Chang-Su Kim
A new set of simply structured triphenylamine-based small molecules are synthesized and evaluated as dopant-free hole transporting materials (HTMs) for high performance perovksite solar cells (PSCs) and bulk heterojunction inverted organic solar cells (BHJ IOSCs). Surprisingly, the new amphiphilic-type HTM-1 (with internal hydrophilic groups and peripheral hydrophobic alkyl tails) showed better compatibility and performance than did the actual target molecule, i.e., HTM-2 in PSCs and BHJ IOSCs. Importantly, the HTM-1-based dopant-free PSCs and BHJ IOSCs exhibited high power conversion efficiencies (PCEs) of 11...
February 13, 2018: Chemistry: a European Journal
Chi Huey Ng, Teresa S Ripolles, Kengo Hamada, Siow Hwa Teo, Hong Ngee Lim, Juan Bisquert, Shuzi Hayase
Perovskite solar cells based on series of inorganic cesium lead bromide and iodide mixture, CsPbBr3-xI x , where x varies between 0, 0.1, 0.2, and 0.3 molar ratio were synthesized by two step-sequential deposition at ambient condition to design the variations of wide band gap light absorbers. A device with high overall photoconversion efficiency of 3.98 % was obtained when small amount of iodide (CsPbBr2.9I0.1) was used as the perovskite and spiro-OMeTAD as the hole transport material (HTM). We investigated the origin of variation in open circuit voltage, Voc which was shown to be mainly dependent on two factors, which are the band gap of the perovskite and the work function of the HTM...
February 6, 2018: Scientific Reports
Robert Roskoski
Platelet-derived growth factor (PDGF) was discovered as a serum-derived component necessary for the growth of smooth muscle cells, fibroblasts, and glial cells. The PDGF family is a product of four gene products and consists of five dimeric isoforms: PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD, and the PDGF-AB heterodimer. This growth factor family plays an essential role in embryonic development and in wound healing in the adult. These growth factors mediate their effects by binding to and activating their receptor protein-tyrosine kinases, which are encoded by two genes: PDGFRA and PDGFRB...
February 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Angela J P Campbell, Lisa A Grohskopf
Influenza vaccination is recommended for all children 6 months of age and older who do not have contraindications. This article provides an overview of information concerning burden of influenza among children in the United States; US-licensed influenza vaccines; vaccine immunogenicity, effectiveness, and safety; and recent updates relevant to use of these vaccines in pediatric populations. Influenza antiviral medications are discussed. Details concerning vaccine-related topics may be found in the current US Centers for Disease Control and Prevention/Advisory Committee on Immunization Practices recommendations for use of influenza vaccines (https://www...
March 2018: Infectious Disease Clinics of North America
Carlos H Villa, Daniel C Pan, Ian H Johnston, Colin F Greineder, Landis R Walsh, Elizabeth D Hood, Douglas B Cines, Mortimer Poncz, Don L Siegel, Vladimir R Muzykantov
Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuman-primate single-chain antibody fragments (scFvs) directed to human RBCs and fused scFvs with human thrombomodulin (hTM) as a representative biotherapeutic cargo (hTM-scFv). Binding fusions to RBCs on band 3/glycophorin A (GPA; Wright b [Wrb] epitope) and RhCE (Rh17/Hr0 epitope) similarly endowed RBCs with hTM activity, but differed in their effects on RBC physiology...
February 13, 2018: Blood Advances
Wei-Feng Guo, Shao-Wu Zhang, Qian-Qian Shi, Cheng-Ming Zhang, Tao Zeng, Luonan Chen
BACKGROUND: The advances in target control of complex networks not only can offer new insights into the general control dynamics of complex systems, but also be useful for the practical application in systems biology, such as discovering new therapeutic targets for disease intervention. In many cases, e.g. drug target identification in biological networks, we usually require a target control on a subset of nodes (i.e., disease-associated genes) with minimum cost, and we further expect that more driver nodes consistent with a certain well-selected network nodes (i...
January 19, 2018: BMC Genomics
Guorong Li, Karen Y Torrejon, Andrea M Unser, Feryan Ahmed, Iris D Navarro, Rudolf A Baumgartner, David S Albers, W Daniel Stamer
Purpose: To evaluate the relationship between the IOP-lowering effect of trabodenoson and the associated structural and functional changes in the trabecular meshwork (TM). Methods: Six independent cohorts of young and aged mice were exposed to three different topical once-a-day formulations of trabodenoson and eyes were compared to those treated with placebo drops. IOP was measured daily just before drug administration using rebound tonometry. Outflow facility was measured in enucleated eyes...
January 1, 2018: Investigative Ophthalmology & Visual Science
Zhengyang Bin, Haoqing Guo, Ziyang Liu, Feng Li, Lian Duan
Precursors of reactive organic radicals have been widely used as n-dopants in electron-transporting materials to improve electron-conductivity and enhance electron-injection. However, the utilization of organic radicals in hole-counterparts has been ignored. In this work, stable organic radicals have been proved for the first time to be efficient dopants to enhance hole injection. From the absorbance spectra and the ultraviolet photoelectron spectra, we could observe an efficient electron transfer between the organic radical (4-N-carbazolyl-2,6-dichlorophenyl)bis(2,4,6-trichlorophenyl)methyl, TTM-1Cz) and the widely used hole injection material (1,4,5,8,9,11-hexaazatriphenylene hexacarbonitrile, HAT-CN)...
January 18, 2018: ACS Applied Materials & Interfaces
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