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https://www.readbyqxmd.com/read/28073946/a-randomized-phase-iii-trial-of-comparing-two-dose-fractionations-stereotactic-body-radiotherapy-sbrt-for-medically-inoperable-stage-ia-non-small-cell-lung-cancer-or-small-lung-lesions-clinically-diagnosed-as-primary-lung-cancer-japan-clinical-oncology-group
#1
EDITORIAL
Tomoki Kimura, Yasushi Nagata, Junko Eba, Shuichi Ozawa, Satoshi Ishikura, Taro Shibata, Yoshinori Ito, Masahiro Hiraoka, Yasumasa Nishimura
A randomized Phase III trial commenced in Japan in February 2016. Currently, 42 Gy in four fractions of stereotactic body radiotherapy prescribed at the D95% of the planning target volume, which is considered equal to the commonly used 48 Gy in four fractions at the isocenter using an old dose calculation algorithm, is the standard treatment in Japan for medically inoperable Stage IA non-small cell lung cancer and small lung lesions clinically diagnosed as primary lung cancer. This study aims to examine the superiority of 55 Gy in four fractions over 42 Gy in four fractions...
January 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28057680/an-informative-approach-on-differential-abundance-analysis-for-time-course-metagenomic-sequencing-data
#2
Dan Luo, Sara Ziebell, Lingling An
MOTIVATION: The advent of high-throughput next generation sequencing technology has greatly promoted the field of metagenomics where previously unattainable information about microbial communities can be discovered. Detecting differentially abundant features (e.g., species or genes) plays a critical role in revealing the contributors (i.e., pathogens) to the biological or medical status of microbial samples. However, currently available statistical methods lack power in detecting differentially abundant features contrasting different biological or medical conditions, in particular, for time series metagenomic sequencing data...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28056098/a-model-for-good-governance-of-healthcare-technology-management-in-the-public-sector-learning-from-evidence-informed-policy-development-and-implementation-in-benin
#3
P Th Houngbo, H L S Coleman, M Zweekhorst, Tj De Cock Buning, D Medenou, J F G Bunders
Good governance (GG) is an important concept that has evolved as a set of normative principles for low- and middle-income countries (LMICs) to strengthen the functional capacity of their public bodies, and as a conditional prerequisite to receive donor funding. Although much is written on good governance, very little is known on how to implement it. This paper documents the process of developing a strategy to implement a GG model for Health Technology Management (HTM) in the public health sector, based on lessons learned from twenty years of experience in policy development and implementation in Benin...
2017: PloS One
https://www.readbyqxmd.com/read/28052725/paracrine-activity-from-adipose-derived-stem-cells-on-in-vitro-wound-healing-in-human-tympanic-membrane-keratinocytes
#4
Huan Ting Ong, Sharon Redmond, Robert Marano, Marcus Atlas, Magnus von Unge, Peder Aabel, Rodney J Dilley
Stem cell therapies for tympanic membrane repair have shown initial experimental success using mesenchymal stem cells in rat models to promote healing, however the mechanisms providing this benefit are not known. We investigated in vitro the paracrine effects of human adipose-derived stem cells (ADSC) on wound healing mechanisms for human tympanic membrane-derived keratinocytes (hTM) and immortalised human keratinocytes (HaCat). ADSC conditioned media (CMADSC) were assessed for paracrine activity on keratinocyte proliferation and migration, with hypoxic conditions for ADSC culture used to generate contrasting effects on cytokine gene expression...
January 4, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28052541/emerging-of-inorganic-hole-transporting-materials-for-perovskite-solar-cells
#5
REVIEW
Ramireddy Rajeswari, Madoori Mrinalini, Seelam Prasanthkumar, Lingamallu Giribabu
Hole transporting material (HTM) is a significant component to achieve the high performance perovskite solar cells (PSCs). Over the years, inorganic, organic and hybrid (organic-inorganic) material based HTMs have been developed and investigated successfully. Today, perovskite solar cells achieved the efficiency of 22.1 % with with 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenyl-amine) 9,9-spirobifluorene (spiro-OMeTAD) as HTM. Nevertheless, synthesis and cost of organic HTMs is a major challenging issue and therefore alternative materials are required...
January 4, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28032258/core-curriculum-illustration-acute-pyelonephritis
#6
Muhammad Mubashir Ramzan, Claire Kalsch Sandstrom
This is the 26th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online please visit the ASER Core Curriculum and Recommendations for Study online at: http://www.aseronline.org/curriculum/toc.htm .
December 28, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/28031185/metadcn-meta-analysis-framework-for-differential-co-expression-network-detection-with-an-application-in-breast-cancer
#7
Li Zhu, Ying Ding, Cho-Yi Chen, Lin Wang, Zhiguang Huo, SungHwan Kim, Christos Sotiriou, Steffi Oesterreich, George C Tseng
MOTIVATION: Gene co-expression network analysis from transcriptomic studies can elucidate genegene interactions and regulatory mechanisms. Differential co-expression analysis helps further detect alterations of regulatory activities in case/control comparison. Co-expression networks estimated from single transcriptomic study is often unstable and not generalizable due to cohort bias and limited sample size. With the rapid accumulation of publicly available transcriptomic studies, co-expression analysis combining multiple transcriptomic studies can provide more accurate and robust results...
December 28, 2016: Bioinformatics
https://www.readbyqxmd.com/read/28013282/fractional-flow-reserve-derived-from-coronary-computed-tomography-angiography-diagnostic-performance-in-hypertensive-and-diabetic-patients
#8
Ashkan Eftekhari, James Min, Stephan Achenbach, Mohamed Marwan, Matthew Budoff, Jonathon Leipsic, Sara Gaur, Jesper Møller Jensen, Brian S Ko, Evald Høj Christiansen, Anne Kaltoft, Hans Erik Bøtker, Jens Flensted Jensen, Bjarne Linde Nørgaard
AIMS: Fractional flow reserve (FFR) derived from coronary computed tomography (FFRCT) has high diagnostic performance in stable coronary artery disease (CAD). The diagnostic performance of FFRCT in patients with hypertension (HTN) and diabetes (DM), who are at risk of microvascular impairment, is not known. METHODS AND RESULTS: We analysed the diagnostic performance of FFRCT, in patients (vessels) with DM (n = 16), HTN (n = 186), DM + HTN (n = 58) vs...
December 24, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27990177/matk-qr-classifier-a-patterns-based-approach-for-plant-species-identification
#9
Ravi Prabhakar More, Rupali Chandrashekhar Mane, Hemant J Purohit
BACKGROUND: DNA barcoding is widely used and most efficient approach that facilitates rapid and accurate identification of plant species based on the short standardized segment of the genome. The nucleotide sequences of maturaseK (matK) and ribulose-1, 5-bisphosphate carboxylase (rbcL) marker loci are commonly used in plant species identification. Here, we present a new and highly efficient approach for identifying a unique set of discriminating nucleotide patterns to generate a signature (i...
2016: BioData Mining
https://www.readbyqxmd.com/read/27976519/tetraphenylmethane-arylamine-hole-transporting-materials-for-perovskite-solar-cells
#10
Xuepeng Liu, Fantai Kong, Tai Cheng, Wangchao Chen, Zhao'ao Tan, Ting Yu, Fuling Guo, Jian Chen, Jianxi Yao, Songyuan Dai
A new class of hole transporting materials containing tetraphenylmethane core have been developed. After thermal, charge carrier mobility and contact angle tests, it is found that TPA-TPM show a higher glass transition temperature and larger water contact angle than spiro-OMeTAD with comparable hole mobility. Photoluminescence and impedance spectroscopy study indicate that TPA-TPM own comparable hole extraction ability with spiro-OMeTAD. Scanning electron microscope and atomic force microscopy results suggest that TPA-TPM show a smooth surface...
December 15, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27960426/carbon-based-cspbbr3-perovskite-solar-cells-all-ambient-processes-and-high-thermal-stability
#11
Xiaowen Chang, Weiping Li, Liqun Zhu, Huicong Liu, Huifang Geng, Sisi Xiang, Jiaming Liu, Haining Chen
The device instability has been an important issue for hybrid organic-inorganic halide perovskite solar cells (PSCs). This work intends to address this issue by exploiting inorganic perovskite (CsPbBr3) as light absorber, accompanied by replacing organic hole transport materials (HTM) and the metal electrode with a carbon electrode. All the fabrication processes (including those for CsPbBr3 and the carbon electrode) in the PSCs are conducted in ambient atmosphere. Through a systematical optimization on the fabrication processes of CsPbBr3 film, carbon-based PSCs (C-PSCs) obtained the highest power conversion efficiency (PCE) of about 5...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27956680/analgesic-efficacy-of-bilateral-continuous-transversus-abdominis-plane-blocks-using-an-oblique-subcostal-approach-in-patients-undergoing-laparotomy-for-gynaecological-cancer-a-prospective-randomized-triple-blind-placebo-controlled-study
#12
T Yoshida, K Furutani, Y Watanabe, N Ohashi, H Baba
BACKGROUND: The analgesic efficacy of continuous transversus abdominis plane (TAP) blocks in comparison with that of single-injection TAP blocks is not clear. This randomized, triple-blind, placebo-controlled trial investigated the benefits of adding continuous TAP blocks to single-injection TAP blocks after a laparotomy. METHODS: Eighty consecutive patients undergoing midline laparotomy for gynaecological cancer were randomized and received bilateral TAP infusions with either ropivacaine 0...
December 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27939447/differential-response-and-withdrawal-profile-of-glucocorticoid-treated-human-trabecular-meshwork-cells
#13
Guorong Li, Gang Cui, W Michael Dismuke, Iris Navarro, Kristin Perkumas, David F Woodward, W Daniel Stamer
The goal of the study was to examine secreted protein response and withdrawal profiles from cultured human trabecular meshwork (HTM) cells following short- and long-term glucocorticoid treatment. Primary cultures of five human HTM cell strains isolated from 5 different individual donor eyes were tested. Confluent HTM cells were differentiated in culture media containing 1% FBS for at least one week, and then treated with Dexamethasone (Dex, 100 nM) 3 times/week for 1 or 4 weeks. Cell culture supernatant was collected 3 times per week for 8 weeks...
December 7, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27935300/interface-play-between-perovskite-and-hole-selective-layer-on-the-performance-and-stability-of-perovskite-solar-cells
#14
Manuel Salado, Jesus Idigoras, Laura Calio, Samrana Kazim, Mohammad Khaja Nazeeruddin, Juan A Anta, Shahzada Ahmad
Perovskite solar cells with variety of hole selective contacts such as 2,2',7,7'-tetrakis(N,N-di-p-methoxyphenylamine)-9,9'-spirobifluorene (Spiro-OMeTAD), poly(3-hexylthiophene-2,5-diyl), poly[bis(4-phenyl)(2,5,6-trimentlyphenyl)amine], 5,10,15-trihexyl-3,8,13-tris(4-methoxyphenyl)-10,15-dihydro-5H-diindolo[3,2-a:3',2'-c]carbazole (HMPDI), and 2',7'-bis(bis(4-methoxyphenyl)amino)spiro[cyclopenta[2,1-b:3,4-b']dithiophene-4,9'-fluorene] were employed to elucidate its role at the interface of perovskite and metallic cathode...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27924833/tgf%C3%AE-2-induced-outflow-alterations-in-a-bioengineered-trabecular-meshwork-are-offset-by-a-rho-associated-kinase-inhibitor
#15
Karen Y Torrejon, Ellen L Papke, Justin R Halman, Magnus Bergkvist, John Danias, Susan T Sharfstein, Yubing Xie
Members of the transforming growth factor beta (TGFβ) cytokine family have long been associated with affecting several cellular functions, including cell proliferation, differentiation and extracellular matrix (ECM) turnover. Of particular interest to this work, TGFβ2 has been linked to most types of glaucomas as a potential fibrotic agent that can cause elevation of intraocular pressure (IOP). Given that the trabecular meshwork (TM) provides most of aqueous humor outflow resistance in the eye, an in vitro bioengineered human TM (HTM) model has been created and validated by analyzing effects of TGFβ2 on transcellular pressure changes and outflow facility...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27919703/prediction-and-mechanism-elucidation-of-analyte-retention-on-phospholipid-stationary-phases-iam-hplc-by-in-silico-calculated-physico-chemical-descriptors
#16
Giacomo Russo, Lucia Grumetto, Francesco Barbato, Giulio Vistoli, Alessandro Pedretti
The present study proposes a method for an in silico calculation of phospholipophilicity. Phospholipophilicity is intended as the measure of analyte affinity for phospholipids; it is currently assessed by HPLC measures of analyte retention on phosphatidylcholine-like stationary phases (IAM - Immobilized Artificial Membrane) resulting in log kW(IAM) values. Due to the amphipathic and electrically charged nature of phospholipids, retention on these stationary phases results from complex mechanisms, being affected not only by lipophilicity (as measured by n-octanol/aqueous phase partition coefficients, log P) but also by the occurrence of polar and/or electrostatic intermolecular interaction forces...
December 3, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27909158/off-site-emergency-planning-at-uk-nuclear-licensed-sites
#17
Paul Leonard, Gareth Thomas
Nuclear emergency planning arrangements in the UK are continually kept under review. This work proposes to outline how experience from nuclear exercises and undertaking emergency response duties can be based on radiological knowledge of specific sites and utilised in the future. In 2014, the UK regulator, the Office for Nuclear Regulation (ONR) revised their principles for the determination of off-site emergency planning areas around nuclear sites where predetermined countermeasures and other protection measures are applied to protect those people who may be affected by a radiation emergency...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27891553/core-curriculum-illustration-dural-venous-sinus-thrombosis
#18
Sibi Rajendran, Alex Pereira, Morgan Eckerd, Barbara Pawley
This is the 25th installment of a series that will highlight one case per publication issue from the bank of cases available online as a part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for study online at http://www.aseronline.org/curriculum/toc.htm .
November 28, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27882554/study-of-heat-moisture-treatment-of-potato-starch-granules-by-chemical-surface-gelatinization
#19
Josiane Bartz, Elessandra da Rosa Zavareze, Alvaro Renato Guerra Dias
BACKGROUND: Native potato starch was heat-moisture treated (HMT) at 12, 15, 18, 21 and 24 % of moisture content at 110 °C for 1 h and the effects on morphology, structure, thermal and physicochemical properties were investigated. To reveal the internal structure, 30 and 50 % of the granular surface were removed by chemical surface gelatinization in concentrated LiCl solution. RESULTS: At moisture contents of 12 and 15 %, the HTM reduced the gelatinization temperatures and relative crystallinity of the starches while at moisture contents of 21 and 24 % both increased...
November 23, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27878244/microrna%C3%A2-93-is-overexpressed-and-induces-apoptosis-in-glaucoma-trabecular-meshwork-cells
#20
Yansa Wang, Fenghua Li, Shuyun Wang
Glaucoma is an optic neuropathy and a major cause of blindness globally. Trabecular meshwork cells are important in maintaining aqueous humor flow, the dysfunction of which tends to induce glaucoma. As important regulators of gene expression, microRNAs may be crucial in regulating trabecular meshwork cells. The present study aimed to reveal the effect of microRNA‑93 (miR‑93) on glaucoma trabecular meshwork (GTM) cell apoptosis. The expression levels of miR‑93 were compared between human trabecular meshwork (HTM) cells and GTM cells...
December 2016: Molecular Medicine Reports
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