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https://www.readbyqxmd.com/read/28062291/pathological-vicissitudes-and-oxidative-stress-enzyme-responses-in-mice-experimentally-infected-with-reptarenavirus-isolate-upm-my01
#1
Yusuf Abba, Hasliza Hassim, Hazilawati Hamzah, Omar Emad Ibrahim, Mohd Azmi Mohd Lila, Mohamed Mustapha Noordin
Boid inclusion body disease (BIBD) is a viral disease of boid snakes believed to be caused by reptarenavirus belonging to the family Arenaviridae. Unlike most mammalian arenaviruses, the reservoir host for reptarenavirus is still unknown. In this study, the pathological responses were evaluated in a mouse model for a period of 28 days. Blood and tissue samples (lung, liver, spleen, heart, kidney and brain) were collected for evaluation of hematology, biochemistry, histopathology and oxidative enzyme levels at six time points (1, 3, 7, 14, 21 and 28 days), after viral infection (2...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28048670/tu-fg-brc-01-cancer-and-the-immune-system-the-basics
#2
E Repasky
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048588/tu-fg-brc-04-opportunities-for-medical-physics-contributions-to-radiation-immunotherapy
#3
M Oldham
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048005/tu-fg-brc-02-radiation-therapy-to-ignite-an-anti-cancer-immune-response
#4
S Formenti
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047342/tu-fg-brc-03-current-clinical-trials-using-radiation-and-immunomodulatory-agents
#5
N Coleman
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046619/tu-fg-brc-00-radiation-and-immunotherapy-how-to-ignite-long-term-anti-cancer-response
#6
Mark Oldham
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027149/thirteenth-annual-warren-k-sinclair-keynote-address-where-are-the-radiation-professionals-warp
#7
Richard E Toohey
In July 2013, the National Council on Radiation Protection and Measurements convened a workshop for representatives from government, professional organizations, academia, and the private sector to discuss a potential shortage of radiation protection professionals in the not-too-distant future. This shortage manifests itself in declining membership of professional societies, decreasing enrollment in university programs in the radiological sciences, and perhaps most importantly, the imminent retirement of the largest birth cohort in American history, the so-called "baby boomer" generation...
February 2017: Health Physics
https://www.readbyqxmd.com/read/28024651/dedicated-mass-casualty-incident-hospitals-an-overview
#8
J J Mark Haverkort, Mirjam B de Jong, Maurizio Foco, Daniele Gui, Masad Barhoum, Gila Hyams, Hany Bahouth, Michael Halberthal, Luke P H Leenen
INTRODUCTION: Hospitals worldwide are preparing for mass casualty incidents (MCIs). The Major Incident Hospital in the Netherlands was constructed 25 years ago as a dedicated hospital for situations wherein a sudden increase in medical surge capacity is mandated to handle an MCI. Over the years, more initiatives of dedicated MCIs have arisen. Herein, we compared the MCI facilities from three countries considering the reasons for construction and the functionality. METHODS: Three dedicated mass casualty hospitals and one hospital with a largely fortified structure were compared...
November 23, 2016: Injury
https://www.readbyqxmd.com/read/27994284/assessment-of-ebola-virus-disease-preparedness-in-the-who-south-east-asia-region
#9
Sirenda Vong, Reuben Samuel, Philip Gould, Hammam El Sakka, Bardan J Rana, Vason Pinyowiwat, Supriya Bezbaruah, Roderico Ofrin
OBJECTIVE: To conduct assessments of Ebola virus disease preparedness in countries of the World Health Organization (WHO) South-East Asia Region. METHODS: Nine of 11 countries in the region agreed to be assessed. During February to November 2015 a joint team from WHO and ministries of health conducted 4-5 day missions to Bangladesh, Bhutan, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand and Timor-Leste. We collected information through guided discussions with senior technical leaders and visits to hospitals, laboratories and airports...
December 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27983611/minimizing-spatial-variability-of-healthcare-spatial-accessibility-the-case-of-a-dengue-fever-outbreak
#10
Hone-Jay Chu, Bo-Cheng Lin, Ming-Run Yu, Ta-Chien Chan
Outbreaks of infectious diseases or multi-casualty incidents have the potential to generate a large number of patients. It is a challenge for the healthcare system when demand for care suddenly surges. Traditionally, valuation of heath care spatial accessibility was based on static supply and demand information. In this study, we proposed an optimal model with the three-step floating catchment area (3SFCA) to account for the supply to minimize variability in spatial accessibility. We used empirical dengue fever outbreak data in Tainan City, Taiwan in 2015 to demonstrate the dynamic change in spatial accessibility based on the epidemic trend...
December 13, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27983505/modeling-tool-for-decision-support-during-early-days-of-an-anthrax-event
#11
Gabriel Rainisch, Martin I Meltzer, Sean Shadomy, William A Bower, Nathaniel Hupert
Health officials lack field-implementable tools for forecasting the effects that a large-scale release of Bacillus anthracis spores would have on public health and hospitals. We created a modeling tool (combining inhalational anthrax caseload projections based on initial case reports, effects of variable postexposure prophylaxis campaigns, and healthcare facility surge capacity requirements) to project hospitalizations and casualties from a newly detected inhalation anthrax event, and we examined the consequences of intervention choices...
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27936340/high-morning-blood-pressure-surge-is-associated-with-oxidative-stress-and-paraoxonase-1-activity-in-newly-diagnosed-hypertensive-patients
#12
Onur Kaypaklı, Mustafa Gür, Hazar Harbalıoğlu, Taner Şeker, Şahabettin Selek
BACKGROUND: Both oxidative stress and morning surge (MS) of blood pressure (BP) were found to be closely related with cardiovascular and cerebrovascular diseases. We investigated the association between MS of BP and oxidative stress in newly diagnosed hypertensive patients. METHODS: We prospectively included 237 newly diagnosed hypertensive patients in the present study (mean age: 51.6 ± 11.7 years). The patients were classified according to the extent of the sleep-through surge as follows: the top decile of sleep-through surge (>47...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27916341/hospital-influenza-pandemic-stockpiling-needs-a-computer-simulation
#13
Mark N Abramovich, John C Hershey, Byron Callies, Amesh A Adalja, Pritish K Tosh, Eric S Toner
BACKGROUND: A severe influenza pandemic could overwhelm hospitals but planning guidance that accounts for the dynamic interrelationships between planning elements is lacking. We developed a methodology to calculate pandemic supply needs based on operational considerations in hospitals and then tested the methodology at Mayo Clinic in Rochester, MN. METHODS: We upgraded a previously designed computer modeling tool and input carefully researched resource data from the hospital to run 10,000 Monte Carlo simulations using various combinations of variables to determine resource needs across a spectrum of scenarios...
December 2, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27777148/eleclazine-an-inhibitor-of-the-cardiac-late-sodium-current-is-superior-to-flecainide-in-suppressing-catecholamine-induced-ventricular-tachycardia-and-t-wave-alternans-in-an-intact-porcine-model
#14
Danilo Bacic, Juliana Saran Carneiro, Afonso Alves Bento, Bruce D Nearing, Sridharan Rajamani, Luiz Belardinelli, Richard L Verrier
BACKGROUND: The capacity of catecholamines to induce ventricular tachycardia (VT) is well documented. OBJECTIVE: The effectiveness of the novel cardiac late sodium inhibitor eleclazine in suppressing catecholamine-induced VT in a large animal model was compared with that of flecainide. METHODS: In 13 closed-chest anesthetized Yorkshire pigs, spontaneous VT and surges in T-wave alternans (TWA) level measured using the Modified Moving Average method were induced by epinephrine (2...
October 21, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27721413/mechanistic-validation-of-a-clinical-lead-stapled-peptide-that-reactivates-p53-by-dual-hdm2-and-hdmx-targeting
#15
F Wachter, A M Morgan, M Godes, R Mourtada, G H Bird, L D Walensky
Hydrocarbon-stapled peptides that display key residues of the p53 transactivation domain have emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in cancer by dual targeting of the negative regulators HDM2 and HDMX. A recent study questioned the mechanistic specificity of such stapled peptides based on interrogating their capacity to disrupt p53/HDM2 and p53/HDMX complexes in living cells using a new recombinase enhanced bimolecular luciferase complementation platform (ReBiL)...
October 10, 2016: Oncogene
https://www.readbyqxmd.com/read/27716813/human-resources-for-treating-hiv-aids-are-the-preventive-effects-of-antiretroviral-treatment-a-game-changer
#16
Till Bärnighausen, David E Bloom, Salal Humair
Shortages of human resources for treating HIV/AIDS (HRHA) are a fundamental barrier to reaching universal antiretroviral treatment (ART) coverage in developing countries. Previous studies suggest that recruiting HRHA to attain universal ART coverage poses an insurmountable challenge as ART significantly increases survival among HIV-infected individuals. While new evidence about ART's prevention benefits suggests fewer infections may mitigate the challenge, new policies such as treatment-as-prevention (TasP) will exacerbate it...
2016: PloS One
https://www.readbyqxmd.com/read/27710702/state-of-the-art-advances-in-radiation-biodosimetry-for-mass-casualty-events-involving-radiation-exposure
#17
Mary Sproull, Kevin Camphausen
With the possibility of large-scale terrorist attacks around the world, the need for modeling and development of new medical countermeasures for potential future chemical, biological, radiological and nuclear (CBRN) has been well established. Project Bioshield, initiated in 2004, provided a framework to develop and expedite research in the field of CBRN exposures. To respond to large-scale population exposures from a nuclear event or radiation dispersal device (RDD), new methods for determining received dose using biological modeling became necessary...
November 2016: Radiation Research
https://www.readbyqxmd.com/read/27692892/the-role-of-nature-based-infrastructure-nbi-in-coastal-resiliency-planning-a-literature-review
#18
Firas Saleh, Michael P Weinstein
The use of nature-based infrastructure (NBI) has attracted increasing attention in the context of protection against coastal flooding. This review is focused on NBI approaches to improve coastal resilience in the face of extreme storm events, including hurricanes. We not only consider the role of NBI as a measure to protect people and property but also in the context of other ecological goods and services provided by tidal wetlands including production of fish and shellfish. Although the results of many studies suggest that populated areas protected by coastal marshes were less likely to experience damage when exposed to the full force of storm surge, it was absolutely critical to place the role of coastal wetlands into perspective by noting that while tidal marshes can reduce wave energy from low-to-moderate-energy storms, their capacity to substantially reduce storm surge remains poorly quantified...
December 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27679975/multifaceted-role-of-hair-follicle-dermal-cells-in-bioengineered-skins
#19
C A Higgins, M Roger, R Hill, A S Ali-Khan, J Garlick, A M Christiano, C A B Jahoda
BACKGROUND: The method to generate bioengineered skin constructs was pioneered several decades ago, and nowadays these constructs are used regularly for the treatment of severe burns and non-healing wounds. Commonly, these constructs are comprised of skin fibroblasts within a collagen scaffold, forming the skin dermis, and stratified keratinocytes overlying this, forming the skin epidermis. In the past decade there has been a surge of interest in bioengineered skins, with researchers searching for alternative cell sources, or scaffolds, from which constructs can be established, and for more biomimetic equivalents with skin appendages...
September 28, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27626015/assessment-of-hospital-management-and-surge-capacity-in-disasters
#20
Hamidreza Shabanikiya, Hasan Abolghasem Gorgi, Hesam Seyedin, Mehdi Jafari
BACKGROUND: Hospital administrators play a key role in the effective management of surge capacity in disasters, but there is little information available about the characteristics required to manage this. OBJECTIVES: In this study, we aimed to identify characteristics of hospital administrators that are important in the effective management of surge capacity in disasters. MATERIALS AND METHODS: This was a qualitative study. Semi-structured purposive interviews were conducted with 28 hospital administrators who had experience working in surge situations in hospitals during disasters...
May 2016: Trauma Monthly
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