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https://www.readbyqxmd.com/read/28202653/argentine-ants-linepithema-humile-use-adaptable-transportation-networks-to-track-changes-in-resource-quality
#1
Tanya Latty, Michael J Holmes, James C Makinson, Madeleine Beekman
Transportation networks play a crucial role in human and animal societies. For a transportation network to be efficient, it must have adequate capacity to meet traffic demand. Network design becomes increasingly difficult in situations where traffic demand can change unexpectedly. In humans, network design is often constrained by path dependency because it is difficult to move a road once it is built. A similar issue theoretically faces pheromone-trail-laying social insects; once a trail has been laid, positive feedback makes re-routing difficult because new trails cannot compete with continually reinforced pre-existing trails...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28192373/cardiac-nuclear-receptors-architects-of-mitochondrial-structure-and-function
#2
Rick B Vega, Daniel P Kelly
The adult heart is uniquely designed and equipped to provide a continuous supply of energy in the form of ATP to support persistent contractile function. This high-capacity energy transduction system is the result of a remarkable surge in mitochondrial biogenesis and maturation during the fetal-to-adult transition in cardiac development. Substantial evidence indicates that nuclear receptor signaling is integral to dynamic changes in the cardiac mitochondrial phenotype in response to developmental cues, in response to diverse postnatal physiologic conditions, and in disease states such as heart failure...
February 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28152138/effect-of-reverse-triage-on-creation-of-surge-capacity-in-a-pediatric-hospital
#3
Gabor D Kelen, Ruben Troncoso, Joshua Trebach, Scott Levin, Gai Cole, Caitlin M Delaney, J Lee Jenkins, James Fackler, Lauren Sauer
Importance: The capacity of pediatric hospitals to provide treatment to large numbers of patients during a large-scale disaster remains a concern. Hospitals are expected to function independently for as long as 96 hours. Reverse triage (early discharge), a strategy that creates surge bed capacity while conserving resources, has been modeled for adults but not pediatric patients. Objective: To estimate the potential of reverse triage for surge capacity in an academic pediatric hospital...
February 6, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28142365/hip-and-knee-osteoarthritis-affects-younger-people-too
#4
Ilana N Ackerman, Joanne L Kemp, Kay M Crossley, Adam G Culvenor, Rana S Hinman
Synopsis Although osteoarthritis (OA) has traditionally been considered a disease of older age, hip and knee OA can and does affect younger adults, with a profound impact on psychosocial well-being and work capacity. Obesity and a history of traumatic knee injury (eg, anterior cruciate ligament rupture and/or meniscal tear) are key risk factors for the accelerated development of knee OA, while structural hip deformities (including those contributing to femoroacetabular impingement syndrome) are strong predictors of early-onset hip OA...
February 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28128812/the-2009-pandemic-in-mexico-experience-and-lessons-regarding-national-preparedness-policies-for-seasonal-and%C3%A2-epidemic-influenza
#5
Jose A Cordova-Villalobos, Alejandro E Macias, Mauricio Hernandez-Avila, Guillermo Dominguez-Cherit, Hugo Lopez-Gatell, Celia Alpuche-Aranda, Samuel Ponce de León-Rosales
Influenza is a viral respiratory disease capable of causing epidemics that represent a threat for global security. Mexico was the first country to notify the WHO of an outbreak of what later became the first influenza pandemic of the 21st Century, caused by the virus A(H1N1)2009. Before this event Mexico had a national pandemic influenza preparedness plan, which included seasonal influenza vaccination, stockpiles of personal protection equipment and strategic drugs, and risk communication strategies. During the epidemic, the national public health laboratory network and case surveillance systems were strengthened together with surge capacities for intensive care and delivery of antiviral drugs...
January 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28115033/development-of-an-evacuation-tool-to-facilitate-disaster-preparedness-use-in-a-planned-evacuation-to-support-a-hospital-move
#6
Ranna A Rozenfeld, Sally L Reynolds, Sherri Ewing, Mary Margaret Crulcich, Michelle Stephenson
OBJECTIVES: Our institution relocated to a new facility 3.5 miles from our original location in Chicago on June 9, 2012. We describe the tools we developed to prepare, execute, and manage our evacuation and relocation. METHODS: Tools developed for the planned evacuation included the following: level of acuity and team composition classification, patient departure checklist, evacuation handoff tool, and a patient tracking system within the electronic health record...
January 24, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28062291/pathological-vicissitudes-and-oxidative-stress-enzyme-responses-in-mice-experimentally-infected-with-reptarenavirus-isolate-upm-my01
#7
Yusuf Abba, Hasliza Hassim, Hazilawati Hamzah, Omar Emad Ibrahim, Mohd Azmi Mohd Lila, Mohamed Mustapha Noordin
Boid inclusion body disease (BIBD) is a viral disease of boid snakes believed to be caused by reptarenavirus belonging to the family Arenaviridae. Unlike most mammalian arenaviruses, the reservoir host for reptarenavirus is still unknown. In this study, the pathological responses were evaluated in a mouse model for a period of 28 days. Blood and tissue samples (lung, liver, spleen, heart, kidney and brain) were collected for evaluation of hematology, biochemistry, histopathology and oxidative enzyme levels at six time points (1, 3, 7, 14, 21 and 28 days), after viral infection (2...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28048670/tu-fg-brc-01-cancer-and-the-immune-system-the-basics
#8
E Repasky
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048588/tu-fg-brc-04-opportunities-for-medical-physics-contributions-to-radiation-immunotherapy
#9
M Oldham
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048005/tu-fg-brc-02-radiation-therapy-to-ignite-an-anti-cancer-immune-response
#10
S Formenti
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047342/tu-fg-brc-03-current-clinical-trials-using-radiation-and-immunomodulatory-agents
#11
N Coleman
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046619/tu-fg-brc-00-radiation-and-immunotherapy-how-to-ignite-long-term-anti-cancer-response
#12
Mark Oldham
: There is substantial current interest in the potential of radiation therapy for synergizing with novel immunotherapies to transform irradiated tumor into an immunogenic hub with capacity to ignite a powerful and adaptive longterm anti-cancer response. Interest stems from new insights into fundamental mechanisms underlying interactions between cancer, radiation and the immune system. Radically new immunotherapy approaches have been proposed, which target the immune system, rather than the cancer itself...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027149/thirteenth-annual-warren-k-sinclair-keynote-address-where-are-the-radiation-professionals-warp
#13
Richard E Toohey
In July 2013, the National Council on Radiation Protection and Measurements convened a workshop for representatives from government, professional organizations, academia, and the private sector to discuss a potential shortage of radiation protection professionals in the not-too-distant future. This shortage manifests itself in declining membership of professional societies, decreasing enrollment in university programs in the radiological sciences, and perhaps most importantly, the imminent retirement of the largest birth cohort in American history, the so-called "baby boomer" generation...
February 2017: Health Physics
https://www.readbyqxmd.com/read/28024651/dedicated-mass-casualty-incident-hospitals-an-overview
#14
J J Mark Haverkort, Mirjam B de Jong, Maurizio Foco, Daniele Gui, Masad Barhoum, Gila Hyams, Hany Bahouth, Michael Halberthal, Luke P H Leenen
INTRODUCTION: Hospitals worldwide are preparing for mass casualty incidents (MCIs). The Major Incident Hospital in the Netherlands was constructed 25 years ago as a dedicated hospital for situations wherein a sudden increase in medical surge capacity is mandated to handle an MCI. Over the years, more initiatives of dedicated MCIs have arisen. Herein, we compared the MCI facilities from three countries considering the reasons for construction and the functionality. METHODS: Three dedicated mass casualty hospitals and one hospital with a largely fortified structure were compared...
February 2017: Injury
https://www.readbyqxmd.com/read/27994284/assessment-of-ebola-virus-disease-preparedness-in-the-who-south-east-asia-region
#15
Sirenda Vong, Reuben Samuel, Philip Gould, Hammam El Sakka, Bardan J Rana, Vason Pinyowiwat, Supriya Bezbaruah, Roderico Ofrin
OBJECTIVE: To conduct assessments of Ebola virus disease preparedness in countries of the World Health Organization (WHO) South-East Asia Region. METHODS: Nine of 11 countries in the region agreed to be assessed. During February to November 2015 a joint team from WHO and ministries of health conducted 4-5 day missions to Bangladesh, Bhutan, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand and Timor-Leste. We collected information through guided discussions with senior technical leaders and visits to hospitals, laboratories and airports...
December 1, 2016: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/27983611/minimizing-spatial-variability-of-healthcare-spatial-accessibility-the-case-of-a-dengue-fever-outbreak
#16
Hone-Jay Chu, Bo-Cheng Lin, Ming-Run Yu, Ta-Chien Chan
Outbreaks of infectious diseases or multi-casualty incidents have the potential to generate a large number of patients. It is a challenge for the healthcare system when demand for care suddenly surges. Traditionally, valuation of heath care spatial accessibility was based on static supply and demand information. In this study, we proposed an optimal model with the three-step floating catchment area (3SFCA) to account for the supply to minimize variability in spatial accessibility. We used empirical dengue fever outbreak data in Tainan City, Taiwan in 2015 to demonstrate the dynamic change in spatial accessibility based on the epidemic trend...
December 13, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27983505/modeling-tool-for-decision-support-during-early-days-of-an-anthrax-event
#17
Gabriel Rainisch, Martin I Meltzer, Sean Shadomy, William A Bower, Nathaniel Hupert
Health officials lack field-implementable tools for forecasting the effects that a large-scale release of Bacillus anthracis spores would have on public health and hospitals. We created a modeling tool (combining inhalational anthrax caseload projections based on initial case reports, effects of variable postexposure prophylaxis campaigns, and healthcare facility surge capacity requirements) to project hospitalizations and casualties from a newly detected inhalation anthrax event, and we examined the consequences of intervention choices...
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27936340/high-morning-blood-pressure-surge-is-associated-with-oxidative-stress-and-paraoxonase-1-activity-in-newly-diagnosed-hypertensive-patients
#18
Onur Kaypaklı, Mustafa Gür, Hazar Harbalıoğlu, Taner Şeker, Şahabettin Selek
BACKGROUND: Both oxidative stress and morning surge (MS) of blood pressure (BP) were found to be closely related with cardiovascular and cerebrovascular diseases. We investigated the association between MS of BP and oxidative stress in newly diagnosed hypertensive patients. METHODS: We prospectively included 237 newly diagnosed hypertensive patients in the present study (mean age: 51.6 ± 11.7 years). The patients were classified according to the extent of the sleep-through surge as follows: the top decile of sleep-through surge (>47...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27916341/hospital-influenza-pandemic-stockpiling-needs-a-computer-simulation
#19
Mark N Abramovich, John C Hershey, Byron Callies, Amesh A Adalja, Pritish K Tosh, Eric S Toner
BACKGROUND: A severe influenza pandemic could overwhelm hospitals but planning guidance that accounts for the dynamic interrelationships between planning elements is lacking. We developed a methodology to calculate pandemic supply needs based on operational considerations in hospitals and then tested the methodology at Mayo Clinic in Rochester, MN. METHODS: We upgraded a previously designed computer modeling tool and input carefully researched resource data from the hospital to run 10,000 Monte Carlo simulations using various combinations of variables to determine resource needs across a spectrum of scenarios...
December 2, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27777148/eleclazine-an-inhibitor-of-the-cardiac-late-sodium-current-is-superior-to-flecainide-in-suppressing-catecholamine-induced-ventricular-tachycardia-and-t-wave-alternans-in-an-intact-porcine-model
#20
Danilo Bacic, Juliana Saran Carneiro, Afonso Alves Bento, Bruce D Nearing, Sridharan Rajamani, Luiz Belardinelli, Richard L Verrier
BACKGROUND: The capacity of catecholamines to induce ventricular tachycardia (VT) is well documented. OBJECTIVE: The effectiveness of the novel cardiac late sodium inhibitor eleclazine in suppressing catecholamine-induced VT in a large animal model was compared with that of flecainide. METHODS: In 13 closed-chest anesthetized Yorkshire pigs, spontaneous VT and surges in T-wave alternans (TWA) level measured using the Modified Moving Average method were induced by epinephrine (2...
October 21, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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