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https://www.readbyqxmd.com/read/29214385/sealing-effects-on-the-storage-stability-of-the-cyanide-antidotal-candidate-dimethyl-trisulfide
#1
Lóránd Kiss, Anna Duke, Kristof Kovacs, Tibor Barcza, Márton Kiss, Ilona Petrikovics, David E Thompson
BACKGROUND: Dimethyl trisulfide (DMTS) is a highly lipid-soluble cyanide (CN) antidote candidate molecule. In prior studies with various US FDA-approved co-solvents, surfactants, and their combinations, aqueous solutions containing 15% polysorbate 80 (Poly80) were found to effectively solubilize DMTS in formulations for intramuscular administration. However, DMTS formulated in 15% aqueous Poly80 solutions showed gradual losses over time when stored in vials with septum-based seals. OBJECTIVE: The present study tested whether storing DMTS formulations in hermetically sealed glass ampules could mitigate storage losses...
December 6, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/29198239/medical-response-to-the-tianjin-explosions-lessons-learned
#2
Jin-Jun Zhang, Tian-Bing Wang, Da Fan, Jun Zhang, Bao-Guo Jiang
BACKGROUND: On August 12, 2015, a hazardous chemical explosion occurred in the Tianjin Port of China. The explosions resulted in 165 deaths, 8 missing people, injuries to thousands of people. We present the responses of emergency medical services and hospitals to the explosions and summarize the lessons that can be learned. METHODS: This study was a retrospective analysis of the responses of emergency medical services and hospitals to the Tianjin explosions. Data on injuries, outcomes, and patient flow were obtained from the government and the hospitals...
December 4, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29197316/developing-a-mass-casualty-surge-capacity-protocol-for-emergency-medical-services-to-use-for-patient-distribution
#3
Samuel E Shartar, Brooks L Moore, Lori M Wood
OBJECTIVES: Metropolitan areas must be prepared to manage large numbers of casualties related to a major incident. Most US cities do not have adequate trauma center capacity to manage large-scale mass casualty incidents (MCIs). Creating surge capacity requires the distribution of casualties to hospitals that are not designated as trauma centers. Our objectives were to extrapolate MCI response research into operational objectives for MCI distribution plan development; formulate a patient distribution model based on research, hospital capacities, and resource availability; and design and disseminate a casualty distribution tool for use by emergency medical services (EMS) personnel to distribute patients to the appropriate level of care...
December 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29189694/committee-opinion-no-726-hospital-disaster-preparedness-for-obstetricians-and-facilities-providing-maternity-care
#4
(no author information available yet)
Large-scale catastrophic events and infectious disease outbreaks highlight the need for disaster planning at all community levels. Features unique to the obstetric population (including antepartum, intrapartum, postpartum and neonatal care) warrant special consideration in the event of a disaster. Pregnancy increases the risks of untoward outcomes from various infectious diseases. Trauma during pregnancy presents anatomic and physiologic considerations that often can require increased use of resources such as higher rates of cesarean delivery...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29189692/committee-opinion-no-726-summary-hospital-disaster-preparedness-for-obstetricians-and-facilities-providing-maternity-care
#5
(no author information available yet)
Large-scale catastrophic events and infectious disease outbreaks highlight the need for disaster planning at all community levels. Features unique to the obstetric population (including antepartum, intrapartum, postpartum and neonatal care) warrant special consideration in the event of a disaster. Pregnancy increases the risks of untoward outcomes from various infectious diseases. Trauma during pregnancy presents anatomic and physiologic considerations that often can require increased use of resources such as higher rates of cesarean delivery...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29173258/the-1917-halifax-explosion-the-first-coordinated-local-civilian-medical-response-to-disaster-in-canada
#6
Chryssa N McAlister, Allan E Marble, T Jock Murray
The 1917 Halifax Explosion was an unfortunate but predictable tragedy, given the sea traffic and munitions cargo, resulting in sudden large-scale damage and catastrophic injuries, with 1950 dead and 8000 injured. Although generous support was received from the United States, the bulk of the medical work was undertaken using local resources through an immediate, massive, centrally coordinated medical response. The incredible care provided 100 years ago by these Canadian physicians, nurses and students is often forgotten, but deserves attention...
December 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29170331/34%C3%A2-a-systematic-literature-review-of-the-pre-hospital-lessons-identified-following-mass-casualty-deliberate-bombing-incidents
#7
Thomas Cooke, Adam Chesters, Gareth Grier
BACKGROUND: Since the end of World War II, there has been an emergence of explosives used amongst civilian populations resulting in mass-casualty incidents. The development of pre-hospital medical systems, worldwide, has resulted in an increased response at these incidents. However, information about the pre-hospital medical response is sparse and not collated. This review aimed to collect and appraise the literature on the pre-hospital management of mass-casualty bombing incidents. The primary objective was to identify and discuss the common themes highlighted as problems in the pre-hospital medical response...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29170304/7%C3%A2-mass-casualty-incidents-a-review-of-triage-severity-planning-assumptions
#8
Paul Hunt
BACKGROUND: Recent events involving a significant number of casualties have emphasised the importance of appropriate preparation for receiving hospitals, especially Emergency Departments, during the initial response phase of a major incident. Development of a mass casualty resilience and response framework in the Northern Trauma Network included a review of existing planning assumptions in order to ensure effective resource allocation, both in local receiving hospitals and system-wide...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29151402/difference-in-first-aid-activity-during-mass-casualty-training-based-on-having-taken-an-educational-course
#9
Youichi Yanagawa, Kazuhiko Omori, Kouhei Ishikawa, Ikuto Takeuchi, Kei Jitsuiki, Toshihiko Yoshizawa, Jun Sato, Hideyuki Matsumoto, Masaru Tsuchiya, Hiromichi Osaka
BACKGROUND: The Japanese Association for Disaster Medicine developed a mass casualty life support (MCLS) course to improve cooperation among medical practitioners during a disaster, which is essential for reducing the rates of preventable disaster death. We investigated whether there was difference in first aid activity among members of the ambulance service during mass casualty training based on having taken the MCLS course. METHODS: Mass casualty training was held at the fire department of Numazu City...
November 20, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29149359/-preclinical-and-intrahospital-management-of-mass-casualties-and-terrorist-incidents
#10
REVIEW
A Franke, D Bieler, B Friemert, E Kollig, S Flohe
Due to the recent terrorist attacks in Paris, Brussels, Ansbach, Munich, Berlin and more recently Manchester and London, terrorism is realized as a present threat to our society and social life, as well as a challenge for the health care system. Without fueling anxiety, there is a need for sensitization to this subject and to familiarize all concerned with the special kind of terrorist attack-related injuries, the operational priorities and tactics and the individual basic principles of preclinical and hospital care...
October 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29123602/rehabilitation-of-vulnerable-groups-in-emergencies-and-disasters-a-systematic-review
#11
REVIEW
Hojjat Sheikhbardsiri, Mohammad H Yarmohammadian, Fatemeh Rezaei, Mohammad Reza Maracy
BACKGROUND: Natural and man-made disasters, especially those occurring in large scales not only result in human mortality, but also cause physical, psychological, and social disabilities. Providing effective rehabilitation services in time can decrease the frequency of such disabilities. The aim of the current study was to perform a systematic review related to rehabilitation of vulnerable groups in emergencies and disasters. METHODS: The systematic review was conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29122057/novel-it-application-for-reverse-triage-selection-a-pilot-study
#12
Gwen Pollaris, Stéphanie Note, Didier Desruelles, Marc Sabbe
OBJECTIVE: The objective of this study was to develop and evaluate an evidence-based information technology (IT) application that guides clinical decision-making during the reverse-triage selection process in mass casualty incidents. METHODS: Based upon 28 validated critical interventions (CI) relevant for determining whether a patient qualifies for early discharge, we developed the Reverse Triage Tool of Leuven (RTTL). The RTTL is compatible with the health electronic record (HER) of UZ Leuven, a tertiary hospital in Belgium...
November 10, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29120063/systematic-sonography-for-detection-of-occult-wounds-in-trauma
#13
Jordan Rupp, Warren Cooper, Robinson Ferre
Treating victims of penetrating trauma is challenging, especially in a mass-casualty or resource-limited setting. The traditional focused assessment with sonography for trauma examination is a well-established clinical tool in the initial evaluation of trauma victims. This article describes a novel technique of systematic sonography of the abdomen to look for occult wounds, which is used in conjunction with the focused assessment with sonography for trauma examination to evaluate occult intraperitoneal injury and improve patient treatment and use of resources...
November 9, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29119221/preparing-japanese-surgeons-for-potential-mass-casualty-situations-will-require-innovative-and-systematic-programs
#14
H Uchino, V Y Kong, J L Bruce, G V Oosthuizen, W Bekker, G L Laing, D L Clarke
INTRODUCTION: The ongoing state of global geo-political instability means that it is prudent to prepare civilian surgeons to manage major military-type trauma. Japan has enjoyed a prolonged period of peace and consequently it is unlikely that surgeons will have been exposed to a sufficient volume of cases. This study reviews the state of trauma training and preparedness in Japan and reviews the trauma workload of a major Japanese emergency medical center and compared with a major South African trauma center with the intention of quantifying and comparing the time needed to gain adequate exposure to major trauma at the two centers...
November 8, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29104014/continuous-positive-airway-pressure-an-early-intervention-to-prevent-phosgene-induced-acute-lung-injury
#15
Stuart Graham, Sarah Fairhall, Steve Rutter, Philippa Auton, Rachel Rendell, Adam Smith, Rosi Perrott, Tim Nicholson Roberts, Bronwen Jugg
Exposure to toxic industrial chemicals such as phosgene may occur through accidental or deliberate release. Inhalation may result in an acute lung injury which manifests as hypoxaemia with insufficient oxygen being delivered to the tissues resulting in hypoxia, respiratory failure and death. No effective pharmacological therapy currently exists and treatment remains supportive, often requiring intensive care facilities. In a mass casualty scenario the logistical burden of managing exposed individuals would rapidly overwhelm healthcare systems...
November 2, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29101834/mass-casualty-education-for-undergraduate-nursing-students-in-australia
#16
Jane Currie, Sarah Kourouche, Christopher Gordon, Christine Jorm, Sandra West
With the increasing risk of mass casualty incidents from extreme climate events, global terrorism, pandemics and nuclear incidents, it's important to prepare nurses with skills and knowledge necessary to manage such incidents. There are very few documented accounts of the inclusion of mass casualty education within undergraduate nursing programs. This paper is the first to describe undergraduate mass casualty nursing education in Australia. A final year Bachelor of Nursing undergraduate subject was developed...
October 28, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29099859/agomelatine-venlafaxine-and-running-exercise-effectively-prevent-anxiety-and-depression-like-behaviors-and-memory-impairment-in-restraint-stressed-rats
#17
Sarawut Lapmanee, Jantarima Charoenphandhu, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra, Narattaphol Charoenphandhu
Several severe stressful situations, e.g., natural disaster, infectious disease out break, and mass casualty, are known to cause anxiety, depression and cognitive impairment, and preventive intervention for these stress complications is worth exploring. We have previously reported that the serotonin-norepinephrine-dopamine reuptake inhibitor, venlafaxine, as well as voluntary wheel running are effective in the treatment of anxiety- and depression-like behaviors in stressed rats. But whether they are able to prevent deleterious consequences of restraint stress in rats, such as anxiety/depression-like behaviors and memory impairment that occur afterward, was not known...
2017: PloS One
https://www.readbyqxmd.com/read/29070605/lessons-in-planning-from-mass-casualty-events-in-uk
#18
EDITORIAL
Christopher G Moran, Catherine Webb, Karim Brohi, Martin Smith, Keith Willett
No abstract text is available yet for this article.
October 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29060951/systematic-node-management-mechanism-using-zigbee-based-real-time-vital-sign-information-monitoring-system-to-manage-large-numbers-of-patients
#19
Ke-Feng Lin, Shih-Sung Lin, Min-Hsiung Hung, Chung-Hsien Kuo, Ping-Nan Chen
BACKGROUND: Local hospitals must deal with large numbers of patients during mass casualty incidents, and the wireless sensor networks (WSNs) can help in these situations by monitoring vital signs. Conventional ZigBee nodes can obtain the ID of a device by assigning a unique 16-bit short address or by burning firmware into an IC. These methods tend to complicate node management and lack portability. OBJECTIVE: The study developed a node management mechanism to deal with a large number of patients in real-time, through the wireless monitoring of physiological signals...
October 13, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29041994/hospital-surge-capacity-a-web-based-simulation-tool-for-emergency-planners
#20
Matthew F Toerper, Gabor D Kelen, Lauren M Sauer, Jamil D Bayram, Christina Catlett, Scott Levin
The National Center for the Study of Preparedness and Catastrophic Event Response (PACER) has created a publicly available simulation tool called Surge (accessible at http://www.pacerapps.org) to estimate surge capacity for user-defined hospitals. Based on user input, a Monte Carlo simulation algorithm forecasts available hospital bed capacity over a 7-day period and iteratively assesses the ability to accommodate disaster patients. Currently, the tool can simulate bed capacity for acute mass casualty events (such as explosions) only and does not specifically simulate staff and supply inventory...
October 18, 2017: Disaster Medicine and Public Health Preparedness
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