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https://www.readbyqxmd.com/read/28649659/inflammation-of-mammary-adipose-tissue-occurs-in-overweight-and-obese-patients-exhibiting-early-stage-breast-cancer
#1
Charlotte Vaysse, Jon Lømo, Øystein Garred, Frøydis Fjeldheim, Trygve Lofteroed, Ellen Schlichting, Anne McTiernan, Hanne Frydenberg, Anders Husøy, Steinar Lundgren, Morten W Fagerland, Elin Richardsen, Erik A Wist, Catherine Muller, Inger Thune
Growing evidence indicates that adiposity is associated with breast cancer risk and negatively affects breast cancer recurrence and survival, a paracrine role of mammary adipose tissue being very likely in this process. In contrast to other adipose depots, occurrence of a sub-inflammatory state of mammary adipose tissue defined by dying adipocytes surrounded by macrophages forming crown-like structures in overweight and obese subjects, remains only partially described. In a general population of breast cancer patients (107 patients) mostly undergoing breast-conserving surgery, we found a positive association between patient's body composition, breast adipocytes size, and presence of crown-like structures in mammary adipose tissue close to the tumor...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#2
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28550173/experimental-cardiac-radiation-exposure-induces-ventricular-diastolic-dysfunction-with-preserved-ejection-fraction
#3
Hirofumi Saiki, Gilles Moulay, Adam J Guenzel, Weibin Liu, Teresa Decklever, Kelly Classic, Linh Pham, Horng H Chen, John C Burnett, Stephen J Russell, Margaret M Redfield
BACKGROUND: Breast cancer radiotherapy increases the risk of heart failure (HF) with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radio-resistant but radiation specifically affects coronary microvascular endothelial cells with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28521021/satellite-cell-mediated-breast-muscle-regeneration-decreases-with-broiler-size
#4
M R Daughtry, E Berio, Z Shen, E J R Suess, N Shah, A E Geiger, E R Berguson, R A Dalloul, M E Persia, H Shi, D E Gerrard
Satellite cells (SCs) reside between the sarcolemma and basal lamina of muscle fibers and are the primary contributor of DNA for post-hatch muscle growth and repair. Alterations in SC content or properties by intrinsic and extrinsic factors can have detrimental effects on muscle health and function, and ultimately meat quality. We hypothesized that disrupted SC homeostasis may account in part for the increased breast myopathies observed in growing broilers. To test this hypothesis, we selected broilers with different body weights at comparable ages and studied SC characteristics in vitro and in vivo...
May 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28499941/mtus1-a-gene-encoding-angiotensin-ii-type-2-at2-receptor-interacting-proteins-in-health-and-disease-with-special-emphasis-on-its-role-in-carcinogenesis
#5
REVIEW
Ibrahim Bozgeyik, Onder Yumrutas, Esra Bozgeyik
Loss of tumor suppressor activity is a frequent event in the formation and progression of tumors and has been listed as an important hallmark of cancers. Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor gene which is reported to be frequently down-regulated in a variety of human cancers including pancreas, colon, bladder, head-and-neck, ovarian, breast cancers, gastric, lung cancers. It is also reported to be implicated in several types of pathologies such as cardiac hypertrophy, atherosclerosis, and SLE-like lymphoproliferative diseases...
May 9, 2017: Gene
https://www.readbyqxmd.com/read/28444312/early-posthatch-thermal-stress-affects-breast-muscle-development-and-satellite-cell-growth-and-characteristics-in-broilers
#6
Yogev Piestun, Tomer Patael, Shlomo Yahav, Sandra G Velleman, Orna Halevy
Heat or cold stress, can disrupt well-being and physiological responses in birds. This study aimed to elucidate the effects of continuous heat exposure in the first 2 wk of age on muscle development in broilers, with an emphasis on the pectoralis muscle satellite cell population. Chicks were reared for 13 d under either commercial conditions or a temperature regime that was 5°C higher. Body and muscle weights, as well as absolute muscle growth were lower in heat-exposed chicks from d 6 onward. The number of satellite cells derived from the experimental chicks was higher in the heat-treated group on d 3 but lower on d 8 and 13 compared to controls...
April 24, 2017: Poultry Science
https://www.readbyqxmd.com/read/28374304/septum-enhanced-mammaplasty-in-inferocentral-pedicled-breast-reduction-for-macromastia-and-gigantomastia-patients
#7
Aurelio Portincasa, Francesco Ciancio, Luigi Cagiano, Alessandro Innocenti, Domenico Parisi
BACKGROUND: Inferior pedicle and free nipple grafting are commonly used as breast reduction techniques for patients with breast hypertrophy and gigantomastia. Limitations of these techniques are, respectively, possible vascular compromise and total/partial necrosis of the nipple-areola complex (NAC). The authors describe the innovative inferocentral pedicled reduction mammaplasty (ICPBR) enhanced by preservation of Würinger's septum for severe hypertrophic breasts. MATERIALS AND METHODS: Among 287 breast reductions performed between January 2001 and 2015, 83 (28...
April 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28289618/long-term-follow-up-and-patient-satisfaction-after-reduction-mammoplasty-superomedial-versus-inferior-pedicle
#8
Mohamed Makboul, Mahmoud Abdelhamid, Ghada Al-Attar
BACKGROUND: Surgery for hypertrophied breast represents a challenge for plastic surgeons. The search for a good cosmetic breast has led to the development of many techniques. Objectives for reduction mammoplasty are to achieve elevated, symmetrical breasts, with round shape, good projection, small cicatrices that are not very perceptible, and a lasting result. METHODS: This study was carried out on 60 cases who had done reduction mammoplasty from January 2009 to December 2014...
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28270386/metabolic-obesity-adipose-inflammation-and-elevated-breast-aromatase-in-women-with-normal-body-mass-index
#9
Neil M Iyengar, Kristy A Brown, Xi Kathy Zhou, Ayca Gucalp, Kotha Subbaramaiah, Dilip D Giri, Heba Zahid, Priya Bhardwaj, Nils K Wendel, Domenick J Falcone, Hanhan Wang, Samantha Williams, Michael Pollak, Monica Morrow, Clifford A Hudis, Andrew J Dannenberg
Obesity is associated with breast white adipose tissue (WAT) inflammation, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that have been linked to the pathogenesis of breast cancer. Here, we determined whether metabolic obesity, including changes in breast biology and systemic effects, occurs in a subset of women with normal body mass index (BMI). Breast WAT and fasting blood were collected from 72 women with normal BMI (<25 kg/m(2)) undergoing mastectomy for breast cancer risk reduction or treatment...
April 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28255494/juvenile-breast-hypertrophy-a-successful-breast-reduction-of-14-9-body-weight-without-recurrence-in-a-5-year-follow-up
#10
Akmal Hisham, Marzida Abd Latib, Normala Basiron
Juvenile hypertrophy of the breast (JHB) is a rare and relentless disease affecting women in the peripubertal period. We present a 13-year-old girl with massive bilateral JHB, successfully treated with a breast reduction and free nipple graft technique. A total of 7300 grams of breast tissue had been removed, accounting for 14.9% of the patient's total body weight. Prophylactic hormonal therapy was not commenced. During the 5-year follow-up period, there was no recurrence and the patient remains satisfied with the aesthetic outcome...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28112868/preoperative-weight-loss-program-targeting-women-with-overweight-and-hypertrophy-of-the-breast-a-pilot-study
#11
N R W Geiker, J Horn, A Astrup
Among women with hypertrophic breasts, the clear majority are overweight or obese. Owing to increased risk of complications, women with a body mass index (BMI) above 25 kg m (-2) are precluded from reduction mammaplasty. The primary aim was to investigate if intensive weight loss could ready women with overweight for breast reduction surgery. Six women, all overweight [BMI 30.9 {28.5; 35.8} kg m (-2) ] with symptomatic hypertrophy of the breast, were included a 12-week weight loss program. All women desired reduction mammaplasty and were motivated for preoperational weight loss...
April 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28092230/octamethylcyclotetrasiloxane-d4
#12
(no author information available yet)
Octamethylcyclotetrasiloxane (D4; CAS No. 556-67-2) is used as a monomer in the manufacture of polymeric materials, which are widely used in various industrial and/or medical applications, such as breast implants. D4 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhalation routes of exposure and is not considered to be a dermal or eye irritant or to be a dermal sensitizer. There is no appreciable dermal absorption of D4 based on results from in vivo and in vitro studies...
January 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28062965/patient-satisfaction-and-clinical-outcomes-following-414-breast-reductions-application-of-breast-q
#13
A Cogliandro, M Barone, G Cassotta, S Tenna, B Cagli, P Persichetti
BACKGROUND: The aim of this study was to measure breast satisfaction and quality of life using the BREAST-Q Reduction Module in a large sample of postoperative patients having breast reduction using the inverted T technique. METHODS: With due approval from the ethics committee of our university, 414 patients who were seen in consultation for breast reduction surgery between 2005 and 2015 performed by the same team were asked to fill out BREAST-Q surveys. The patient factors collected for all those undergoing breast reduction included age, body mass index, incision pattern, areola complex pedicle used, amount of tissue resected, concurrent procedures, and complications...
January 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28051831/breast-reduction-personal-technique
#14
P Fino, G Di Taranto, M Toscani, N Scuderi
INTRODUCTION: Macromastia is a health problem that requires the coordination of surgical and medical specialists. Goals of reduction mammaplasty are to alleviate physical, emotional and psychosocial discomforts and to restore a conical-shaped breast, maintaining scars as short as possible. We report our approach for reduction mammaplasty with superior pedicle. MATERIALS AND METHODS: Our method combines advantages of round block with vertical scar, using a dermal flap that is fixed to the new mammary crease...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28027257/evidence-based-medicine-reduction-mammaplasty
#15
REVIEW
Richard Greco, Barrett Noone
LEARNING OBJECTIVES: After reading this article, the participant should be able to: 1. Understand the multiple reduction mammaplasty techniques available for patients and describe the advantages and disadvantages associated with each. 2. Describe the indications for the treatment of macromastia in patients younger than 18 years. 3. Identify the preoperative indications for breast imaging before surgery. 4. Describe the benefits of breast infiltration with local anesthesia with epinephrine before surgery...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27987514/-effects-of-breast-feeding-duration-bottle-feeding-duration-and-oral-habits-on-the-occlusal-characteristics-of-primary-dentition
#16
X X Chen, B Xia, L H Ge, J W Yuan
OBJECTIVE: To assess the effects of breast-feeding duration, bottle-feeding duration and oral habits on the occlusal characteristics of primary dentition in 3-6-year-old children in Beijing. METHODS: This cross sectional study was conducted via an examination of the occlusal characteristics of 734 children combined with a questionnaire completed by their parents/guardians. The examination was performed by a single, previously calibrated examiner and the following variables were evaluated: presence or absence of deep overbite, open bite, anterior cross bite, posterior cross bite, deep overjet, terminal plane relationship of the second primary molar, primary canine relationship, crowding and spacing...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27986772/increased-capacity-for-work-and-productivity-after-breast-reduction
#17
Isaias Vieira Cabral, Edgard da Silva Garcia, Rebecca Neponucena Sobrinho, Natália Lana Larcher Pinto, Yara Juliano, Joel Veiga-Filho, Lydia Masako Ferreira, Daniela Francescato Veiga
BACKGROUND: Breast hypertrophy is a prevalent condition among women worldwide, which can affect different aspects of their quality of life. The physical and emotional impact of breast hypertrophy may harm daily activities, including work. OBJECTIVES: To assess the impact of reduction mammaplasty on the ability to work and productivity of women with breast hypertrophy. METHODS: A total of 60 patients with breast hypertrophy, already scheduled for breast reduction, aged 18 to 60 years and who had formal or autonomous employment were prospectively enrolled...
January 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27921449/reduction-mammaplasty-with-the-modified-round-block-technique-in-chinese-patients-and-its-anatomy-study
#18
Wei Ding, Yinjia Ding, Hua Jiang
BACKGROUND: Although reduction mammaplasty is one of the most common procedures in plastic surgery, it is associated with some serious complications, especially in cases of severe hypertrophy or advanced ptosis, including necrosis of the nipple and areola, absence of normal sensation of the nipple-areolar complex, and loss of lactational function for future nursing. A thorough understanding of the breast anatomy is vital for successful reduction mammaplasty. This article describes the blood supply and innervation of the breasts, and introduces a modified round block technique for reduction mammaplasty based on this anatomy...
December 6, 2016: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/27899130/antibiotic-prophylaxis-in-reduction-mammaplasty-study-protocol-for-a-randomized-controlled-trial
#19
Edgard Silva Garcia, Daniela Francescato Veiga, Joel Veiga-Filho, Isaías Vieira Cabral, Natália Lana Larcher Pinto, Neil Ferreira Novo, Miguel Sabino Neto, Lydia Masako Ferreira
BACKGROUND: The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic treatment on the occurrence of SSI after breast reduction surgery. METHODS: This is a double-blind randomized clinical trial with 124 breast hypertrophy patients allocated to two treatment groups: antibiotic (n = 62) and placebo (n = 62)...
November 30, 2016: Trials
https://www.readbyqxmd.com/read/27874960/surgical-therapy-of-breast-hypertrophy-a-comparison-of-complications-and-satisfaction-rate-in-large-and-small-superior-pedicle-custom-made-reduction-mammaplasty
#20
P Fino, G Di Taranto, M Toscani, N Scuderi
OBJECTIVE: The reduction mammaplasty is indicated for patients with symptomatic breast hypertrophy. Although surgery is considered the gold standard treatment, it is still debated which is the complication rate and whether or not there is an increased complication rate with increased tissue resection per breast. The main objective of this retrospective study was to determine whether the rates of complications are higher in large reductions (≥2000 g per breast) as compared with smaller reductions (≤1999 g per breast) using the superior pedicle custom-made technique...
November 2016: European Review for Medical and Pharmacological Sciences
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