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breast hypertrophy

Ilaria Tocco-Tussardi, Nathalie Mobargha, Franco Bassetto, Vincenzo Vindigni
INTRODUCTION: Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is a benign lesion with a female predominance and an aesthetically disturbing appearance. Spontaneous remission is not reported and medical treatments proposed so far have shown variable results. PRESENTATION OF CASE: We describe a rare case of an extensive variant of NHNA covering almost the entire breasts' surface. At present, only three other reports are present in the literature. Medical treatment proved not completely effective and the patient was also affected by a significant breast asymmetry-hypertrophy...
September 22, 2016: International Journal of Surgery Case Reports
Jade Chapman, Scott Ingram
In breast reduction and mastopexy procedures, the periareolar closure forms a vital component of the surgery. Periareolar closures completed with an absorbable suture may be prone to significant widening, hypertrophy and/or areolar distortion. In an effort to avoid this, some surgeons use a non-absorbable/permanent suture material [Franco (Arch Plast Surg 41 (6): 728-733, 2014)]. Hammond (Plast Reconstr Surg 119 (3):804-809, 2007) recommends the use of a Gore-Tex® suture for this purpose in view of the supple, pliable nature of the material; however, there remain at least occasional instances of infection and extrusion of the knot used to tie off the Gore-Tex "purse-string" [Franco (Arch Plast Surg 41 (6): 728-733, 2014); Salgarello (Aesthet Plast Surg 37 (5):1061-1062, 2013)]...
September 8, 2016: Aesthetic Plastic Surgery
Seyed Abolhassan Emami, Roohollah Sobhani
AIM OF STUDY: Women with breast hypertrophy often experience a number of physical symptoms and psychological difficulties. The breasts are very important for the psychological well-being of women, which might be affected negatively because of breast size and shape distortions. Self-body dissatisfaction and, in this background, the breasts can lead to low levels of self-confidence and self-esteem, which might affect sexuality. MATERIALS AND METHODS: Thirty-five women with macromastia and their partners were evaluated for their sexual function and surgery satisfaction before and 6 months following reduction mammaplasty...
October 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Benoît Ranchoux, Jolyane Meloche, Roxane Paulin, Olivier Boucherat, Steeve Provencher, Sébastien Bonnet
Pulmonary hypertension (PH) is defined by a mean pulmonary arterial pressure over 25 mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of PH, pulmonary arterial hypertension (PAH) is characterized by a progressive obstruction of distal pulmonary arteries, related to endothelial cell dysfunction and vascular cell proliferation, which leads to an increased pulmonary vascular resistance, right ventricular hypertrophy, and right heart failure. Although the primary trigger of PAH remains unknown, oxidative stress and inflammation have been shown to play a key role in the development and progression of vascular remodeling...
2016: International Journal of Molecular Sciences
C Bruant-Rodier, C Dissaux, A Baratte, C Francois Fiquet, F Bodin
During adolescence, psychological and physical changes occur and breast takes a major place in the young woman body image. Except rare malign tumors, breast pathologies at this age are mainly benign or malformative. Malformative issues are revealed during breast growth, as isolated asymmetry or associated to other regional anomalies, with abnormal shape or volume of the breast, or even supernumerary breast. Therapeutic solutions will not differ from the ones used for adults. Breast lipofilling, recently admitted by plastic surgery community is an interesting tool that can be used on young women...
June 15, 2016: Annales de Chirurgie Plastique et Esthétique
Nyama M Sillah, Jinesh Shah, Eugene Fukudome, Samuel J Lin
Abdominal-based free flaps are commonly used for breast reconstruction, and the internal mammary or thoracodorsal vessels are typically used as recipient sites. Conversely, free tissue transfer is less commonly used for chest wall reconstruction in the setting of chest wall recurrence, in part, because of a paucity of recipient vessels. Here, we describe a case of a 68-year-old female smoker with metastatic breast cancer, who presented with a chest wall recurrence. There was a large area of chronic ulceration with foul smelling drainage, in addition to radiation-induced tissue injury, and palliative resection was performed...
March 2016: Plastic and Reconstructive Surgery. Global Open
Yuhua Fan, Li Liu, Kun Fang, Tao Huang, Lin Wan, Youbin Liu, Sen Zhang, Dongxia Yan, Guangnan Li, Yanhui Gao, Yanjie Lv, Yanjun Chen, Yingfeng Tu
BACKGROUND: The polyphenol resveratrol (Rev) has been reported to exhibit cardioprotective effects, such as inhibition of TAC (transverse aortic constriction) or isoprenaline (ISO)-induced hypertrophy. MicroRNA-155 (miR-155) was found to be decreased in hypertrophic myocardium, which could be further reduced by pretreatment of Rev. The study was designed to investigate the molecular effects of miR-155 on cardiac hypertrophy, focusing on the role of breast cancer type 1 susceptibility protein (BRCA1)...
April 2016: Journal of the American Heart Association
Sandy R Truong, William T Barry, Javid J Moslehi, Emily L Baker, Erica L Mayer, Ann H Partridge
BACKGROUND: Cardiotoxicity can be a complication of anthracycline- or trastuzumab-based therapy for breast cancer patients. Screening echocardiograms (ECHOs) and radionuclide ventriculograms (RVGs) are often performed before administration of these agents to evaluate cardiac function. Limited evidence for the clinical utility of these screening tests is available. METHODS: Early-stage breast cancer patients diagnosed from 2006 to 2011 (n = 1,067) with baseline ECHOs/RVGs were identified in a single institution prospective registry...
June 2016: Oncologist
Gülay Karagüzel, Sevcan Bilen, Naci Karaçal, Kadriye Yıldız, Murat Livaoğlu
BACKGROUND: Virginal breast hypertrophy is a rapid and massive enlargement of one or both breasts. There are several proposed causes and treatment options for virginal breast hypertrophy, but the investigations to support these theories are lacking. CASES: We report two premenarchal girls with virginal breast hypertrophy who presented as different clinical cases. After their surgical interventions, their clinical courses were followed for more than 2 years with tamoxifen as an adjuvant therapy...
October 2016: Journal of Pediatric and Adolescent Gynecology
Esther Pérez-Panzano, Antonio Güemes-Sánchez, Ana Gascón-Catalán
UNLABELLED: Mammary hypertrophy or macromastia can cause a wide range of symptoms (physical, psychosomatic or behavioral), which affect patients' quality of life. Breast reduction can, in most of the cases, solve the problem. However, certain factors could have a negative effect on the outcome of surgery. The aims of this study were to discover the degree of patient satisfaction (short- and long-term) and to evaluate results of reduction mammoplasty, and also to ascertain which factors may have a negative role on the effectiveness of breast reduction surgery...
July 2016: Breast Journal
Karen L Powers, Linda G Phillips
Mammary hypertrophy can occur in the postburn breast. Patients with burned breasts exhibit the same symptoms of symptomatic macromastia as patients with unburned breasts. The extent of the deformity, the location of the deformity, and the status of the surrounding soft tissue are all assessed before embarking on any surgical plan, which then proceeds in a conservative stepwise fashion. Although many plastic surgeons are reluctant to operate on burned breasts for fear of devascularizing the skin graft or nipple areolar complex, reduction mammaplasty in this group of patients is safe and carries minimal risk if key concepts are followed...
April 2016: Clinics in Plastic Surgery
Ayaka Matsumoto, Chiyomi Sakamoto, Haruka Matsumori, Jun Katahira, Yoko Yasuda, Katsuhide Yoshidome, Masahiko Tsujimoto, Ilya G Goldberg, Nariaki Matsuura, Mitsuyoshi Nakao, Noriko Saitoh, Miki Hieda
A supervised machine learning algorithm, which is qualified for image classification and analyzing similarities, is based on multiple discriminative morphological features that are automatically assembled during the learning processes. The algorithm is suitable for population-based analysis of images of biological materials that are generally complex and heterogeneous. Here we used the algorithm wndchrm to quantify the effects on nucleolar morphology of the loss of the components of nuclear envelope in a human mammary epithelial cell line...
2016: Nucleus
Zeynep Karacor-Altuntas, Mehmet Dadaci, Bilsev Ince, Mehtap Karamese, Nedim Savaci
BACKGROUND: Various pedicle techniques have been described in breast reduction surgery. However, in cases of massive hypertrophy, the free nipple graft technique is still being performed by some surgeons out of fear of losing the nipple-areolar complex (NAC). As such, we evaluated patients with severe gigantomastia who underwent the central pedicle horizontal scar reduction mammaplasty technique. METHODS: The records of 257 patients who underwent the central pedicle reduction technique were retrospectively reviewed...
April 2016: Annals of Plastic Surgery
Carolyn Wayne, Jui-Hsia Cleo Hung, Emily Chan, Isabella Sedgwick, Juan Bass, Ahmed Nasr
BACKGROUND: The etiology of infantile hypertrophic pyloric stenosis (HPS) is not fully understood. The objective of this study was to determine whether formula-feeding is associated with increased incidence. METHODS: This case-control study included HPS cases and controls admitted between 1992 and 2012. Demographic data including feeding method were collected from patient charts and analyzed. RESULTS: We identified 882 HPS cases and 955 controls...
May 2016: Journal of Pediatric Surgery
Wess A Cohen, Peter Homel, Nima P Patel
OBJECTIVE: A total of 62,611 patients with breast hypertrophy underwent breast reduction surgery in 2013 in the United States to improve their symptoms and health-related quality of life. While multiple studies utilizing various outcome instruments demonstrate the efficacy of reductive surgery, it is presently unknown how the postoperative course affects patient satisfaction and health-related quality of life as measured by the BREAST-Q. Our objective was to determine the temporal relationship of patient satisfaction and health-related quality of life after reduction mammoplasty...
2016: Eplasty
Mariela M Lopez, Alexander Chase Castillo, Kyle Kaltwasser, Linda G Phillips, Clayton L Moliver
BACKGROUND: Young female subjects are known to have the highest baseline menstrual hormone levels of any female age group. Studies have found an association between hormone levels and wound healing. This has been researched in the orthopedic, gynecologic, and dermatologic literature, and more recently, in young patients undergoing augmentation mammaplasty. The purpose of this study was to determine whether the timing of surgery relative to the menstrual cycle plays a role in surgical complications following bilateral reduction mammaplasty...
February 2016: Plastic and Reconstructive Surgery
Dogu Aydin, Lone Bak Hansen, Peder Ikander, Jennifer Berg Drejøe, Susanne Lambaa, Lisbet Rosenkrantz Hölmich
INTRODUCTION: Indication for breast reduction in a publically funded or an insurance-funded setting depends on the severity of the subjective symptoms and on the clinical evaluation. The purpose of this study was to evaluate whether Danish surgeons follow a clinical practice recommending a minimum tissue resection weight of 400-500 g per breast. METHODS: Included in the study were a total of 366 female patients with breast hypertrophy who underwent bilateral breast reduction surgery at three large university hospitals in Denmark in the period from August 2008 to November 2013...
January 2016: Danish Medical Journal
Shadi Rezai, Jenna T Nakagawa, John Tedesco, Annika Chadee, Sri Gottimukkala, Ray Mercado, Cassandra E Henderson
Background. Gestational gigantomastia is a rare disorder without clear etiology or well-established risk factors. Several pathogenic mechanisms contributing to the disease process have been proposed, all of which can lead to a similar phenotype of breast hypertrophy. Case. A 28-year-old Guinean woman presented at 37 weeks of gestation with bilateral gigantomastia, mastalgia, peau d'orange, and back pain. Prolactin levels were 103.3 μg/L (with a normal reference value for prolactin in pregnancy being 36-372 μg/L)...
2015: Case Reports in Obstetrics and Gynecology
Jun Ho Kim, Jin Hyup Lee, Young Jun Kim
Bazedoxifene (BZA) is a novel selective estrogen receptor modulator that exhibits estrogen agonist activity in the bone but estrogen antagonist activity in the breast and uterus. We recently demonstrated that BZA mimics estrogenic actions in reversing metabolic abnormalities while protecting the endometrium from estrogen stimulation in ovariectomized (OVX) mice. However, it is unknown whether BZA, alone or paired with estrogens, can protect pancreatic β-cell function or survival. Thus, the aim of this study was to evaluate the preventive effects of estrogens [17β-estradiol or conjugated estrogens (CE)], BZA and their combinations against β-cell failure...
November 6, 2015: Biological & Pharmaceutical Bulletin
Paulo Afonso Monteiro Pacheco Guimarães, Vanessa Contato Lopes Resende, Miguel Sabino Neto, Caroline Lumy Seito, Maria José Azevedo de Brito, Luiz Eduardo Felipe Abla, Daniela Francescato Veiga, Lydia Masako Ferreira
BACKGROUND: The breasts are important for a woman's psychological well-being, which may be negatively affected by distortions of breast size and shape. Improvements in self-esteem and sexuality are important psychological factors associated with motivation for cosmetic surgery. Mammaplasty is among the most sought-after and performed cosmetic procedures. The aim of this study was to evaluate the impact of aesthetic breast surgery on a woman's sexuality. METHODS: This study was conducted in a plastic surgery clinic of a hospital university in Brazil, between 2009 and 2012...
December 2015: Aesthetic Plastic Surgery
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