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https://www.readbyqxmd.com/read/28655215/development-of-a-new-method-based-on-unmodified-gold-nanoparticles-and-peptide-nucleic-acids-for-detecting-bovine-viral-diarrhea-virus-rna
#1
Maryam Askaravi, Seyedeh Elham Rezatofighi, Saadat Rastegarzadeh, Masoud Reza Seifi Abad Shapouri
A simple colorimetric assay is presented for detecting bovine viral diarrhea virus (BVDV)-RNA based on aggregation of gold nanoparticles (AuNPs) in the presence of charge-neutral peptide nucleic acids (PNA). Free charge-neutral PNA oligomers tended to be adsorbed onto AuNPs and act as a coagulant, whereas hybridizing complementary RNA with PNA disrupted PNA-induced AuNP aggregation, and the NPs remained stable. However, non-complementary RNA did not have this effect, and PNA induced aggregation of the AuNPs that resulted in a color change of the reaction from red to blue...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28654862/biopolymer-zein-coated-gold-nanoparticles-synthesis-antibacterial-potential-toxicity-and-histopathological-effects-against-the-zika-virus-vector-aedes-aegypti
#2
Periyakaruppan Suganya, Baskaralingam Vaseeharan, Sekar Vijayakumar, Banumathi Balan, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
The control of multidrug-resistant bacteria as well as insect pests and vectors is timely and important now a days. The present study was designed to evaluate the in vitro antibacterial, antibiofilm and mosquito larvicidal effects of gold nanoparticles synthesized using the zein biopolymer (Ze-AuNPs) against Gram positive (Bacillus pumilus and Bacillus subtilis), Gram negative (Shigella sonnei and Pseudomonas aeruginosa) bacteria and third instar larvae of the dengue and Zika virus vector Aedes aegypti. The synthesized Ze-AuNPs were characterized by UV-vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM)...
June 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28654778/a-new-platform-for-serological-analysis-based-on-porous-3-dimensional-polyethylene-sinter-bodies
#3
Mohammed Alasel, Michael Keusgen
A new sensitive and selective platform, three-dimensional immunosensor, has been developed for a rapid serological diagnosis; detection of a Borrelia infection was considered as a model assay. The immunosensor is based on a 3-dimensional (3D) porous solid surface (sinter body) with dimensions of 2×2.5mm where a recombinant variable lipoprotein surface-exposed protein (VlsE; Borrelia-antigen) is immobilized by different techniques. The sinter body served as a robust and inexpensive carrier, which facilitated a successful hydrophobic adsorption as well as covalent immobilization of the antigen with sufficient amounts of on the surface...
June 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28654711/addressing-the-immunopathogenesis-of-atopic-dermatitis-advances-in-topical-and-systemic-treatment
#4
Lawrence F Eichenfield, Linda F Stein Gold
Several immunologic mediators-phosphodiesterase (PDE), interleukin (IL), small molecules, and Janus kinase-have been implicated in the pathogenesis of atopic dermatitis, and evidence has shown that blocking these mediators can help modify the disease process. Several new topical medications have been developed that target the enzyme PDE; crisaborole was recently approved by the US Food and Drug Administration (FDA) for the treatment of atopic dermatitis, and phase II studies have been completed on OPA-15406...
March 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28654710/nonpharmacologic-strategies-and-topical-agents-for-treating-atopic-dermatitis-an-update
#5
Linda F Stein Gold, Lawrence F Eichenfield
The signs and symptoms of atopic dermatitis can be safely and effectively controlled in most patients; in many cases, the disease can be improved to the point that signs and symptoms are absent or minimal. In addition, flares can be effectively controlled and, in some cases, prevented. New topical medications, improved strategies for the use of topical corticosteroids and topical calcineurin inhibitors, and judicious use of nonpharmacologic regimens-including bathing, bleach baths, and early use of emollients-have led to better disease management and improved quality of life for patients and their families...
March 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28654709/atopic-dermatitis-progression-evaluating-intervention-strategies
#6
Linda F Stein Gold, Lawrence F Eichenfield
Several risk factors have been identified that appear to be consistently and strongly associated with the development of atopic dermatitis (AD): a family history of atopy, an inherited genetic predisposition, and active and passive exposure to tobacco smoke. Recent studies also have demonstrated that a simple intervention from birth-the daily application of an emollient moisturizer-seems to protect susceptible infants from the development of AD.
March 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28654708/practical-strategies-for-the-diagnosis-and-assessment-of-atopic-dermatitis
#7
Lawrence F Eichenfield, Linda F Stein Gold
Atopic dermatitis (AD) has a significant, lifelong clinical impact on affected individuals and has profound effects on quality of life both for patients and their families. The diagnosis usually can be reliably established on the basis of the history and physical examination. In patients with skin of color, blanching of the skin may be helpful to detect erythema, lichenification, follicular accentuation, and hypopigmentation (all of which are more common than in lighter-skinned patients). Once the diagnosis of AD is established, an assessment of severity, persistence, and impact on the patient's and family's life is important as a guide to treatment decisions...
March 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28654468/bullous-pemphigoid-use-of-c4d-immunofluorescent-staining-in-a-case-with-repeated-negative-conventional-direct-immunofluorescence-studies
#8
Sarah S Kassaby, Alexander Hicks, Stuart Leicht, George A Youngberg
Direct immunofluorescence (DIF) using frozen section material from a fresh/preserved perilesional biopsy is the gold standard for the immunopathologic diagnosis of bullous pemphigoid (BP). DIF in BP shows linear dermoepidermal junction (DEJ) staining for C3, with or without staining for IgG. In some situations, only a formalin-fixed lesional biopsy is obtained (with no fresh/preserved perilesional biopsy for DIF). In this setting, paraffin section C4d immunohistochemistry has proven to be diagnostically useful, demonstrating linear DEJ positivity for C4d...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654384/fluorescent-plasmonic-and-radiotherapeutic-properties-of-the-177-lu-dendrimer-aunp-folate-bombesin-nanoprobe-located-inside-cancer-cells
#9
Héctor Mendoza-Nava, Guillermina Ferro-Flores, Flor de María Ramírez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Keila Isaac-Olivé
The integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic-photothermal, therapeutic, and radiotherapeutic potential of (177)Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity ((177)Lu-DenAuNP-folate-bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP-folate-bombesin for optical imaging...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28654105/facile-detection-of-glucose-in-human-serum-employing-silver-ion-guided-surface-enhanced-raman-spectroscopy-signal-amplification
#10
Cuicui Fu, Sila Jin, Joohee Oh, Shuping Xu, Young Mee Jung
A facile surface-enhanced Raman scattering (SERS) sensor based on a silver-ion-mediated amplification effect was designed for the determination of glucose concentration. In this approach, 4-aminothiophenol (4-ATP) molecules assembled on the surface of a gold wafer (Au wafer@4-ATP) act not only as Raman tags but also as linkage agents. Silver nanoparticles marked with cysteamine (AgNP@cys) were used as the SERS enhancement components because they could be bound to the Au wafer@4-ATP in the presence of silver ions through the formation of N → Ag(+) ← N coordination compounds...
June 27, 2017: Analyst
https://www.readbyqxmd.com/read/28654073/rapid-deletion-production-in-fungi-via-agrobacterium-mediated-transformation-of-oscar-deletion-constructs
#11
Scott E Gold, Zahi Paz, María D García-Pedrajas, Anthony E Glenn
Precise deletion of gene(s) of interest, while leaving the rest of the genome unchanged, provides the ideal product to determine that particular gene's function in the living organism. In this protocol the OSCAR method of precise and rapid deletion plasmid construction is described. OSCAR relies on the cloning system in which a single recombinase reaction is carried out containing the purified PCR-amplified 5' and 3' flanks of the gene of interest and two plasmids, pA-Hyg OSCAR (the marker vector) and pOSCAR (the assembly vector)...
June 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653959/mechanical-optical-electro-modulation-by-stretching-a-polymer-metal-nanocomposite
#12
Chloe Minnai, Marcel Di Vece, Paolo Milani
We report the simultaneous investigation of both the plasmonic resonance and electrical conductance evolution in stretchable metal-polymer nanocomposite films. The films are produced by the implantation of neutral gold nanoparticles in a Polydimethylsiloxane substrate by aerodynamically acceleration in a supersonic expansion. A redshift of the gold nanoparticle plasmon peak is found upon stretching as well as a strong correlation between the plasmonic peak wavelength and the nanocomposite electrical resistance...
June 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28653753/the-development-of-a-magnetic-resonance-imaging-index-for-fistulising-crohn-s-disease
#13
M A Samaan, C A J Puylaert, B G Levesque, G Y Zou, L Stitt, S A Taylor, L M Shackelton, M K Vandervoort, R Khanna, C Santillan, J Rimola, P Hindryckx, C Y Nio, W J Sandborn, G D'Haens, B G Feagan, V Jairath, J Stoker
BACKGROUND: Magnetic resonance imaging (MRI) is the gold standard for assessment of perianal fistulising Crohn's disease (CD). The Van Assche index is the most commonly used MRI fistula index. AIMS: To assess the reliability of the Van Assche index, and to modify the instrument to improve reliability and create a novel index for fistulising CD. METHODS: A consensus process developed scoring conventions for existing Van Assche index component items and new items...
June 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28653468/chiral-gold-nanoclusters-atomic-level-origins-of-chirality
#14
REVIEW
Chenjie Zeng, Rongchao Jin
Chiral nanomaterials have received wide interest in many areas, but the exact origin of chirality at the atomic level remains elusive in many cases. With recent significant progress in atomically precise gold nanoclusters (e.g., thiolate-protected Aun (SR)m ), several origins of chirality have been unveiled based upon atomic structures determined by using single-crystal X-ray crystallography. The reported chiral Aun (SR)m structures explicitly reveal a predominant origin of chirality that arises from the Au-S chiral patterns at the metal-ligand interface, as opposed to the chiral arrangement of metal atoms in the inner core (i...
June 27, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28653370/multicenter-study-to-evaluate-a-new-enumeration-method-for-hematopoietic-stem-cell-collection-management
#15
Monique Grommé, Henk Russcher, Eric Braakman, J Henriëtte Klinkspoor, Johan A Dobber, Inge de Greef, Norbert C J de Wit
BACKGROUND: CD34 flow cytometry is the gold standard for stem cell enumeration in peripheral blood at the mobilization stage and in the final apheresis product. The new stem cell mode of the Sysmex XN Series analyzer enumerates an immature cell population in the white progenitor and pathological cell (WPC) channel, based on the cell size, internal cellular complexity, and fluorescence intensity. STUDY DESIGN AND METHODS: In this multicenter study we analyzed 147 peripheral blood samples, 22 samples during collection of stem cells, and 45 samples from the apheresis product of 18 healthy allogeneic donors and 84 autologous patients...
June 26, 2017: Transfusion
https://www.readbyqxmd.com/read/28653346/identification-of-young-of-the-year-great-hammerhead-shark-sphyrna-mokarran-in-northern-florida-and-south-carolina
#16
A M Barker, B S Frazier, D M Bethea, J R Gold, D S Portnoy
Two sharks, visually identified in the field as young-of-the-year (YOY) scalloped hammerhead Sphyrna lewini, were identified as great hammerhead Sphyrna mokarran based on nuclear-encoded single nucleotide polymorphisms (SNP) and sequences of mtDNA. Individuals were captured and released in Bulls Bay, SC, and Saint Joseph Bay, FL, in 2013 and 2014, respectively. These findings indicate S. mokarran may be pupping in or around these areas and highlight new regions that may be a productive focus for future research on early life history of S...
June 27, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28653320/%C3%AF-%C3%A2-h-%C3%A2-%C3%AF-hydrogen-bonds-and-their-lithium-and-gold-analogues-mp2-and-caspt2-calculations
#17
Slawomir Janusz Grabowski, Fernando Ruipérez
Molecular systems where two simple π-electron species, acetylene and ethylene, are linked by a cation located between them are analyzed in this study. In particular, the C2H2***M+***C2H2, C2H4***M+***C2H2 and C2H4***M+***C2H4 complexes (M+ = H+, Li+ and Au+) are calculated with the use of MP2 and CASPT2 methods. The Quantum Theory of Atoms in Molecules (QTAIM), energy decomposition analysis (EDA) and Natural Bond Orbital (NBO) approaches are applied to deepen the understanding of the nature of M+***π interactions in these complexes...
June 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28653255/clinical-evaluation-of-near-infrared-light-transillumination-in-approximal-dentin-caries-detection
#18
Gokhan Ozkan, Kadriye Gorkem Ulu Guzel
The objective of this clinical study was to compare conventional caries detection techniques, pen-type laser fluorescence device, and near-infrared light transillumination method in approximal dentin caries lesions. The study included 157 patients, aged 12-18, without any cavity in the posterior teeth. Two calibrated examiners carried out the assessments of selected approximal caries sites independently. After the assessments, the unopened sites were excluded and a total of 161 approximal sites were included in the study...
June 26, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28652935/segal-s-law-16s-rrna-gene-sequencing-and-the-perils-of-foodborne-pathogen-detection-within-the-american-gut-project
#19
James B Pettengill, Hugh Rand
Obtaining human population level estimates of the prevalence of foodborne pathogens is critical for understanding outbreaks and ameliorating such threats to public health. Estimates are difficult to obtain due to logistic and financial constraints, but citizen science initiatives like that of the American Gut Project (AGP) represent a potential source of information concerning enteric pathogens. With an emphasis on genera Listeria and Salmonella, we sought to document the prevalence of those two taxa within the AGP samples...
2017: PeerJ
https://www.readbyqxmd.com/read/28652891/non-alcoholic-fatty-liver-disease-an-expanded-review
#20
REVIEW
Mark Benedict, Xuchen Zhang
Non-alcoholic fatty liver disease (NAFLD) encompasses the simple steatosis to more progressive steatosis with associated hepatitis, fibrosis, cirrhosis, and in some cases hepatocellular carcinoma. NAFLD is a growing epidemic, not only in the United States, but worldwide in part due to obesity and insulin resistance leading to liver accumulation of triglycerides and free fatty acids. Numerous risk factors for the development of NAFLD have been espoused with most having some form of metabolic derangement or insulin resistance at the core of its pathophysiology...
June 8, 2017: World Journal of Hepatology
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