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https://www.readbyqxmd.com/read/29793179/nano-strategies-for-berberine-delivery-a-natural-alkaloid-of-berberis
#1
REVIEW
Elaheh Mirhadi, Mehdi Rezaee, Bizhan Malaekeh-Nikouei
Berberine, as a phytochemical component of some medicinal Chinese herbs (most frequently Berberis vulgaris), is an isoquinoline alkaloid with many therapeutic effects including anti-viral, anti-microbial, anti-diarrhea, anti-inflammatory and anti-tumor effects. Berberine has some significant effects on type 2 diabetes through adenosine monophosphate-activated protein kinase activation, glycolysis stimulation, and mitochondrial function inhibition which subsequently improves both lipid and glucose metabolism...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793125/assessment-of-cam-morphology-of-the-hip-with-ultra-sound-imaging-by-physical-therapists-is-reliable-and-valid
#2
Liliane Mandema, Igor Tak, Brigitte Mooij, Ruud Groeneweg, Eric Bakker, Peter van Veldhoven
BACKGROUND: Femoroacetabular impingement syndrome is considered present when a combination of clinical symptoms, signs and morphological features of the hip co-exist. Imaging is increasingly popular in primary health care settings with physical therapists performing ultrasound (US). OBJECTIVE: The aim of this study was to assess the diagnostic accuracy and inter-rater reliability of ultrasound in determining presence of cam morphology. DESIGN: A concurrent validity and inter-rater reliability study...
April 14, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793089/gold-and-gold-silver-alloy-nanoparticles-enhance-the-myogenic-differentiation-of-myoblasts-through-p38-mapk-signaling-pathway-and-promote-in-vivo-skeletal-muscle-regeneration
#3
Juan Ge, Kai Liu, Wen Niu, Mi Chen, Min Wang, Yumeng Xue, Chuanbo Gao, Peter X Ma, Bo Lei
Under the severe trauma condition, the skeletal muscles regeneration process is inhibited by forming fibrous scar tissues. Understanding the interaction between bioactive nanomaterials and myoblasts perhaps has important effect on the enhanced skeletal muscle tissue regeneration. Herein, we investigate the effect of monodispersed gold and gold-silver nanoparticles (AuNPs and Au-AgNPs) on the proliferation, myogenic differentiation and associated molecular mechanism of myoblasts (C2C12), as well as the in vivo skeletal muscle tissue regeneration...
May 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/29792706/adaptable-detection-strategies-in-membrane-based-immunoassays-calibration-free-quantitation-with-surface-enhanced-raman-scattering-readout
#4
Aleksander Skuratovsky, Robert J Soto, Marc D Porter
This paper presents a method for immunometric biomarker quantitation that uses standard flow-through assay reagents and obviates the need for constructing a calibration curve. The approach relies on a nitrocellulose immunoassay substrate with multiple physical addresses for analyte capture, each modified with different amounts of an analyte-specific capture antibody. As such, each address generates a distinctly different readout signal that is proportional to the analyte concentration in the sample. To establish the feasibility of this concept, equations derived from antibody-antigen binding equilibrium were first applied in modeling experiments...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792684/label-free-optical-marker-for-rbc-phenotyping-of-inherited-anaemias
#5
Martina Mugnano, Pasquale Memmolo, Lisa Miccio, Francesco Merola, Vittorio Bianco, Alessia Bramanti, Antonella Gambale, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Pietro Ferraro
The gold standard methods for anaemia diagnosis are the complete blood count and the peripheral smear observation. However, they do not allow for a complete differential diagnosis, which requires biochemical assays, thus being label-dependent techniques. On the other hand, recent studies focus on label-free quantitative phase imaging (QPI) of blood samples to investigate blood diseases by using video-based morphological methods. However, when sick cells are very similar to healthy ones in terms of morphometric features identification of a blood disease becomes challenging even by morphometric as well as QPI...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792312/identification-of-patients-with-hemoglobin-ss-s%C3%AE-0-thalassemia-disease-and-pain-crises-within-electronic-health-records
#6
Ashima Singh, Javier Mora, Julie A Panepinto
Electronic health records (EHRs) are a source of big data that provide opportunities for conducting population-based studies and creating learning health systems, especially for rare conditions such as sickle cell disease (SCD). The objective of our study is to validate algorithms for accurate identification of patients with hemoglobin (Hb) SS/Sβ0 thalassemia and acute care encounters for pain among SCD patients within EHR warehouse. We used data for children receiving care at Children's Hospital of Wisconsin from 2013 to 2016 to test the accuracy of the 2 algorithms...
June 12, 2018: Blood Advances
https://www.readbyqxmd.com/read/29792228/field-evaluation-of-an-immunochromatographic-test-for-diagnosis-of-cystic-and-alveolar-echinococcosis
#7
Chun-Hua Gao, Jun-Yun Wang, Feng Shi, Dietmar Steverding, Xia Wang, Yue-Tao Yang, Xiao-Nong Zhou
BACKGROUND: The larval stages of the tapeworms Echinocoocus granulosus and Echinococcus multilocularis are the causative agents of human cystic echinococcosis (CE) and human alveolar echinococcosis (AE), respectively. Both CE and AE are chronic diseases characterised by long asymptomatic periods of many years. However, early diagnosis of the disease is important if treatment and management of echinococcosis patients are to be successful. METHODS: A previously developed rapid diagnostic test (RDT) for the differential detection of CE and AE was evaluated under field conditions with finger prick blood samples taken from 1502 people living in the Ganzi Tibetan Autonomous Prefecture, China, a region with a high prevalence for both forms of human echinococcosis...
May 23, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29792146/use-of-bipolar-radiofrequency-catheter-ablation-in-treatment-of-cardiac-arrhythmias
#8
Filip Soucek, Zdenek Starek
Background Arrhythmia management is a complex process involving both pharmacological and non-pharmacological approaches. Radiofrequency ablation is the pillar of non-pharmacological arrhythmia treatment. Unipolar ablation is considered to be the gold standard in the treatment of the majority of arrhythmias; however, its efficacy is limited to specific cases. In particular, the creation of deep or transmural lesions to eliminate intramurally originating arrhythmias remains inadequate. Bipolar ablation is proposed as an alternative to overcome unipolar ablation boundaries...
May 23, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29792059/pitfalls-in-the-diagnosis-of-meningitis-in-neonates-and-young-infants-the-role-of-lumbar-puncture
#9
Luca Bedetti, Lucia Marrozzini, Alessandro Baraldi, Elisabetta Spezia, Lorenzo Iughetti, Laura Lucaccioni, Alberto Berardi
Meningitis occurs frequently in neonates and can lead to a number of acute, severe complications and long-term disabilities. An early diagnosis of neonatal meningitis is essential to reduce mortality and to improve outcomes. Initial clinical signs of meningitis are often subtle and frequently overlap with those of sepsis, and current haematologic tests do not distinguish sepsis from meningitis. Thus, lumbar puncture remains the gold standard for the diagnosis of meningitis in infants, and this procedure is recommended in clinical guidelines...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29792046/annals-express-fast-screening-of-n-glycosylation-disorders-by-sialotransferrin-profiling-with-capillary-zone-electrophoresis
#10
Hermi A Kingma, Fjodor H Van der Sluijs, Rebecca M Heiner-Fokkema
BACKGROUND: Congenital disorders of glycosylation (CDG) are a growing group of rare genetic disorders. The most frequently used screening method is sialotransferrin profiling using isoelectric focussing (IEF). Capillary zone electrophoresis (CZE) may be a simple and fast alternative. We investigated the Capillarys ¬T M CDT assay (Sebia, France) to screen for N-glycosylation disorders, using IEF as gold standard. METHODS: Intra- and interassay precision were established, and analyses in heparin-anticoagulated plasma and serum were compared...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29791800/tip-enhanced-raman-scattering-from-nano-patterned-graphene-and-graphene-oxide
#11
Ashish Bhattarai, Andrey Krayev, Alexey Temiryazev, Dmitry Evplov, Kevin Thomas Crampton, Wayne P Hess, Patrick Z El Khoury
Tip-enhanced Raman spectroscopy (TERS) is particularly sensitive to analytes residing at plasmonic tip-sample nanojunctions, where the incident and scattered optical fields may be localized and optimally enhanced. However, the enhanced local electric fields in this so-called gap-mode TERS configuration are nominally orthogonal to the sample plane. As such, any given Raman active vibrational Eigenstate needs to have projections (of its polarizability derivative tensor elements) along the sample normal to be detectable via TERS...
May 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29791795/surface-acoustic-wave-saw-driven-device-for-dynamic-cell-cultures
#12
Gina Greco, Matteo Agostini, Ilaria Tonazzini, Damiano Sallemi, Stefano Barone, Marco Cecchini
In the last decades new types of cell cultures have been introduced to provide better cell survival and development, and micro/nano-environmental physico-chemical conditions aimed to mimic those present in vivo. However, despite the efforts made, the systems available to date are often difficult to replicate and use. Here, an easy-to-use surface acoustic wave (SAW)-based platform is presented for realizing dynamic cell cultures that is compatible with standard optical microscopes, incubators and cell culture dishes...
May 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29791515/comparison-of-oscillometric-doppler-and-invasive-blood-pressure-measurement-in-anesthetized-goats
#13
Olga Szaluś-Jordanow, Michał Czopowicz, Agata Moroz, Marcin Mickiewicz, Magdalena Garncarz, Emilia Bagnicka, Tadeusz Frymus, Jarosław Kaba
Arterial blood pressure (BP) can be measured directly using an invasive intra-arterial method. This method is considered a gold standard, however it is potentially hazardous and requires expensive equipment and professional skills. Therefore, two non-invasive methods-Doppler ultrasonic sphygmomanometry and oscillometry-have been introduced in veterinary medicine. Their accuracy has so far been reliably evaluated in various animal species, however only one study included a small group of goats. Therefore, we carried out a large-scale study which aimed to evaluate agreement between the two non-invasive methods and invasive intra-arterial BP measurement in anesthetized goats at various age...
2018: PloS One
https://www.readbyqxmd.com/read/29791450/significant-acceleration-of-emergency-response-using-smartphone-geolocation-data-and-a-worldwide-emergency-call-support-system
#14
Michael Weinlich, Peter Kurz, Melissa B Blau, Felix Walcher, Stefan Piatek
IMPORTANCE: When patients are disorientated or experience language barriers, it is impossible to activate the emergency response system. In these cases, the delay for receiving appropriate help can extend to several hours. OBJECTIVES: A worldwide emergency call support system (ECSS), including geolocation of modern smartphones (GPS, WLAN and LBS), was established referring to E911 and eCall systems. The system was tested for relevance in quickly forwarding abroad emergency calls to emergency medical services (EMS)...
2018: PloS One
https://www.readbyqxmd.com/read/29791371/ultrahigh-sensitivity-refractive-index-sensor-of-a-d-shaped-pcf-based-on-surface-plasmon-resonance
#15
JunJun Wu, Shuguang Li, Xinyu Wang, Min Shi, Xinxing Feng, Yundong Liu
We propose a D-shaped photonic crystal fiber (PCF) refractive index sensor with ultrahigh sensitivity and a wide detection range. The gold layer is deposited on the polished surface, avoiding filling or coating inside the air holes of the PCF. The influences of the gold layer thickness and the diameter of the larger air holes are investigated. The sensing characteristics of the proposed sensor are analyzed by the finite element method. The maximum sensitivity can reach 31,000  nm/RIU, and the refractive index detection range is from 1...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791136/precisely-striking-tumor-without-adjacent-normal-tissue-damage-via-mitochondria-templated-accumulation
#16
Zhao-Yu Ma, Kai Han, Xinxin Dai, Heyou Han
Ignored damage in adjacent normal tissue is fatal especially in some specific tumor therapy such as brain tumor, but it remains a great challenge to conquer it due to random drug diffusion and tumor complexity. Herein, we show the hyperthermia in mitochondria, an interparticle plasmonic coupling effect activated nanoevent, selectively strikes tumor tissue without damaging adjacent normal tissue. Spherical gold nanoparticles with a mitochondria-targeting moiety, triphenyl phosphonium, preferentially accumulated inside tumor mitochondria and reached the threshold to activate interparticle plasmonic coupling effect among gold nanoparticles, realizing selective light-thermal conversion and mitochondrial dysfunction in tumor, whereas little hyperthermia and mitochondrial dysfunction were observed in adjacent normal tissue...
May 23, 2018: ACS Nano
https://www.readbyqxmd.com/read/29791049/2-benzoylpyridine-ligand-complexation-with-gold-critical-for-propargyl-ester-based-protein-labeling
#17
Yixuan Lin, Kenward Vong, Koji Matsuoka, Katsunori Tanaka
Previously, Au(III) complexes coordinated with 2-benzoylpyridine ligand, BPy-Au, were prebound to a protein and used to discover a novel protein-directed labelling approach with propargyl ester functional groups. In this work, further examination discovered that gold catalysts devoid of the 2-benzoylpyridine ligand (ex/ NaAuCl4) had significantly reduced levels of protein labeling. Mechanistic investigations then revealed that BPy-Au and propargyl esters undergo a rare example of C(sp2)-C(sp) aryl-alkynyl cross coupling, likely via spontaneous reductive elimination...
May 23, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29790947/antibodies-against-chlamydia-trachomatis-and-ovarian-cancer-risk-in-two-independent-populations
#18
Britton Trabert, Tim Waterboer, Annika Idahl, Nicole Brenner, Louise A Brinton, Julia Butt, Sally B Coburn, Patricia Hartge, Katrin Hufnagel, Federica Inturrisi, Jolanta Lissowska, Alexander Mentzer, Beata Peplonska, Mark E Sherman, Gillian S Wills, Sarah C Woodhall, Michael Pawlita, Nicolas Wentzensen
Background: Pelvic inflammatory disease (PID) has been associated with ovarian cancer risk. To clarify the role of Chlamydia trachomatis and other infectious agents in the development of ovarian cancer, we evaluated the association of serologic markers with incident ovarian cancer using a staged approach in two independent populations. Methods: Studies included: 1) a case-control study in Poland (244 ovarian cancers/556 control subjects) and 2) a prospective nested case-control study in the PLCO Cancer Screening Trial (160 ovarian cancers/159 control subjects)...
May 21, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29790859/neutron-track-length-estimator-for-gate-monte-carlo-dose-calculation-in-radiotherapy
#19
Halima Elazhar, Thomas Deschler, Jean Michel Letang, Abdelmjid Nourreddine, Nicolas Arbor
The out-of-field dose in radiation therapy is a growing concern in regards to the late side-effects and secondary cancer induction. In high-energy X-ray therapy, the secondary neutrons generated through photonuclear reactions in the accelerator are part of this secondary dose. The neutron dose is currently not estimated by the treatment planning system (TPS) while it appears to be preponderant for distances greater than 50~cm from the isocenter. Monte Carlo (MC) simulation has become the gold standard for accurately calculating the neutron dose under specific treatment conditions but the method is also known for having a slow statistical convergence, which makes it difficult to be used on a clinical basis...
May 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29790740/organometallic-gold-iii-reagents-for-cysteine-arylation
#20
Marco S Messina, Julia M Stauber, Mary A Waddington, Arnold L Rheingold, Heather D Maynard, Alexander M Spokoyny
An efficient method for chemoselective cysteine arylation of unprotected peptides and proteins using Au(III) organometallic complexes is reported. The bioconjugation reactions proceed rapidly (<5 min) at ambient temperature in various buffers and within a wide pH range (0.5-14). This approach provides access to a diverse array of S-aryl bioconjugates including fluorescent dye, complex drug molecule, affinity label, poly(ethylene glycol) tags and a stapled peptide. A library of Au(III) arylation reagents can be prepared as air-stable, crystalline solids in one step from commercial reagents...
May 23, 2018: Journal of the American Chemical Society
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