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https://www.readbyqxmd.com/read/28454414/analysis-of-egfr-mutation-status-in-tissue-and-plasma-for-predicting-response-to-egfr-tkis-in-advanced-non-small-cell-lung-cancer
#1
Yuyan Wang, Jianchun Duan, Hanxiao Chen, Hua Bai, Tongtong An, Jun Zhao, Zhijie Wang, Minglei Zhuo, Shuhang Wang, Jie Wang
The detection of mutations in the epidermal growth factor receptor (EGFR) gene in tumor tissues has been established as the gold standard for predicting the efficacy of treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small-cell lung cancer (NSCLC). The current study aimed to investigate whether the presence of co-existing EGFR mutations in tumor tissue and in cell-free tumor DNA (ctDNA) in the plasma predicts a more favorable outcome of EGFR-TKI treatment in advanced NSCLC. A total of 287 NSCLC patients who had undergone EGFR-TKI treatment were enrolled and stratified into four subgroups: Wild-type EGFR in plasma and tissue specimens (B-/T-); mutated EGFR in plasma and tissue specimens (B+/T+); mutated EGFR in only in plasma samples (B+/T-); or mutated EGFR in only tissue specimens (B-/T+)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454328/reconstruction-of-mandibular-defects-with-autogenous-bone-and-decellularized-bovine-bone-grafts-with-freeze-dried-bone-marrow-stem-cell-paracrine-factors
#2
Ann Kakabadze, Konstantine Mardaleishvili, George Loladze, Lia Karalashvili, Gocha Chutkerashvili, David Chakhunashvili, Zurab Kakabadze
The gold standard following segmental mandibulectomy is vascularized autologous bone graft in the form of the fibula flap. However, in bone reconstruction the use of autogenous bone does not always guarantee a successful outcome. The aim of the present investigation was to develop a novel biologically active bone (BAB) graft, and to use it for the reconstruction of large size defects of the mandible bone following tumor resection. In the first part of the present study, biologically active bone graft was developed by using human freeze-dried bone marrow stem cells (BMSCs) paracrine factors and three-dimensional bone scaffold derived from cancellous bovine bone following decellularization...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454245/improving-contrast-enhancement-in-magnetic-resonance-imaging-using-5-aminolevulinic-acid-induced-protoporphyrin-ix-for-high-grade-gliomas
#3
Junkoh Yamamoto, Shingo Kakeda, Tetsuya Yoneda, Shun-Ichiro Ogura, Shohei Shimajiri, Tohru Tanaka, Yukunori Korogi, Shigeru Nishizawa
Magnetic resonance imaging (MRI) with a gadolinium-based contrast agent is the gold standard for high-grade gliomas (HGGs). The compound 5-aminolevulinic acid (5-ALA) undergoes a high rate of cellular uptake, particularly in cancer cells. In addition, fluorescence-guided resection with 5-ALA is widely used for imaging HGGs. 5-ALA is water soluble, while protoporphyrin IX (PpIX) is water insoluble. It was speculated whether converting from 5-ALA to PpIX may relatively increase intracellular water content, and consequently, might enhance the T2 signal intensity in HGG...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454150/selective-propagation-and-beam-splitting-of-surface-plasmons-on-metallic-nanodisk-chains
#4
Yuhui Hu, Di Zhao, Zhenghan Wang, Fei Chen, Xiang Xiong, Ruwen Peng, Mu Wang
Manipulating the propagation of surface plasmons (SPs) on a nanoscale is a fundamental issue of nanophotonics. By using focused electron beam, SPs can be excited with high spatial accuracy. Here we report on the propagation of SPs on a chain of gold nanodisks with cathodoluminescence (CL) spectroscopy. Experimental evidence for the propagation of SPs excited by the focused electron beam is demonstrated. The wavelength of the transmitted SPs depends on the geometrical parameters of the nanodisk chain. Furthermore, we design and fabricate a beam splitter, which selectively transmits SPs of certain wavelengths to a specific direction...
May 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28454098/the-impact-of-receptor-recycling-on-the-exocytosis-of-%C3%AE-v%C3%AE-3-integrin-targeted-gold-nanoparticles
#5
Yanan Cui, Xiaoning Song, Suxin Li, Bing He, Lan Yuan, Wenbing Dai, Hua Zhang, Xueqing Wang, Bin Yang, Qiang Zhang
Among the diverse factors that may influence the therapeutic outcomes, the exocytosis of targeted drug delivery systems (TDDS) and its relationship with the corresponding receptor receive little attentions. In this study, cRGDfK modified gold nanoparticles (cRGDfK-PEG-AuNPs) were synthesized, and their cellular transportation including endocytosis and exocytosis, as well as the potential relations with αvβ3 integrin were carefully studied. The results showed that the enhanced and fast internalization of cRGDfK-PEG-AuNPs into U87 cells was associated with the high expression level of αvβ3 integrin...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454077/comparison-of-ftir-atr-and-raman-spectroscopy-in-determination-of-vldl-triglycerides-in-blood-serum-with-pls-regression
#6
Adam Oleszko, Jadwiga Hartwich, Anna Wójtowicz, Marlena Gąsior-Głogowska, Hubert Huras, Małgorzata Komorowska
Hypertriglyceridemia, related with triglyceride (TG) in plasma above 1.7mmol/L is one of the cardiovascular risk factors. Very low density lipoproteins (VLDL) are the main TG carriers. Despite being time consuming, demanding well-qualified staff and expensive instrumentation, ultracentrifugation technique still remains the gold standard for the VLDL isolation. Therefore faster and simpler method of VLDL-TG determination is needed. Vibrational spectroscopy, including FT-IR and Raman, is widely used technique in lipid and protein research...
April 18, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28454055/evaluation-of-a-commercially-available-radioimmunoassay-and-enzyme-immunoassay-for-the-analysis-of-progesterone-and-estradiol-and-the-comparison-of-two-extraction-efficiency-methods
#7
C S Skenandore, A Pineda, J M Bahr, A E Newell-Fugate, F C Cardoso
The measurement of progesterone (P4) and estradiol (E2) is essential for monitoring reproductive cycles and can aid in diagnosing the cause of poor reproductive performance in dairy cattle. Readily available, reproducible, accurate, non-radioactive assays are needed for the assessment of P4 and E2 in bovine serum. The gold standard for hormone assessment, radioimmunoassay (RIA), was compared with enzyme-linked immunoassay (EIA). Serum collected from various points in the estrous cycle was extracted with radiolabeled P4 (ie, (3)H-P4; HE) and without (3)H-P4 (CE) before being used in the assay...
April 5, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28454046/preliminary-investigation-of-catalytic-antioxidant-anticancer-and-bactericidal-activity-of-green-synthesized-silver-and-gold-nanoparticles-using-actinidia-deliciosa
#8
Saraschandra Naraginti, Yi Li
Herein we report a rapid low cost one step green synthetic method using Actinidia deliciosa fruit extract for preparation of stable and multifunctional silver and gold nanoparticles. The synthesized nanoparticles were successfully used as green catalysts for the reduction of 4-nitrophenol (4-NP) and methylene blue (MB). The enhanced biological activity of the prepared nanoparticles was investigated based on its highly stable antioxidant, anticancer and bactericidal effects. TEM micrographs showed that the silver nanoparticles (AgNPs) formed were predominantly spherical in shape having diameters ranging from 25 to 40nm, while gold nanoparticles (AuNPs) shown particle size ranges from 7 to 20nm...
March 30, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28454043/vacuum-scanning-capillary-photoemission-microscopy
#9
S A Aseyev, A P Cherkun, B N Mironov, V V Petrunin, S V Chekalin
We demonstrate the use of a conical capillary in a scanning probe microscopy for surface analysis. The probe can measure photoemission from a substrate by transmitting photoelectrons along the capillary as a function of probe position. The technique is demonstrated on a model substrate consisting of a gold reflecting layer on a compact disc which has been illuminated by an unfocused laser beam with a wavelength 400nm, from a femtosecond laser with a beam size of 4mm. A quartz capillary with a 2-µm aperture has been used in the experiments...
April 19, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28453943/supercharging-a-mno-sub-2-sub-nanowire-an-amine-altered-morphology-retains-capacity-at-high-rates-and-mass-loadings
#10
Girija Thesma Chandran, Gaurav Jha, Shaopeng Qiao, Mya Le Thai, Rajen Kumar Dutta, Alana F Ogata, Ji-Soo Jang, Il-Doo Kim, Reginald M Penner
The influence of hexamethylenetetraamine (HMTA) on the morphology of δ- MnO<sub>2</sub> and its properties for electrical energy storage are investigated - specifically for ultra-thick δ-MnO<sub>2<\sub> layers in the micron scale. Planar arrays of gold@δ-MnO<sub>2</sub>, core@shell nanowires, were prepared by electrodeposition with and without the HMTA and their elec- trochemical properties evaluated. HMTA alters the MnO<sub>2</sub> in three ways: First, it creates a more open morphology for the MnO<sub>2</sub> coating, characterized by "petals" with a thickness of 6 nm to 9 nm, rather than much thinner δ-MnO<sub>2</sub> sheets seen in the absence of HMTA...
April 28, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28453939/all-atom-molecular-dynamics-simulations-of-peptide-amphiphile-assemblies-that-spontaneously-form-twisted-and-helical-ribbon-structures
#11
Cheng-Tsung Lai, Nathaniel L Rosi, George C Schatz
Self-assembly of peptide amphiphiles (PAs) has been an active research area as the assemblies can be programmed into various shaped nanostructures. Although cylindrical micelles are common structures, gold-binding peptide conjugates PEPAu can self-assemble into chiral nanofibers with single or double helices. When gold nanoparticles bind to the helices, the resulting chiral nanoparticle assemblies have a collective plasmonic circular dichroism signal that can serve as nanoscale circular polarizers or chiroptical sensors...
April 28, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28453936/metallic-twin-grain-boundaries-embedded-in-mose2-monolayers-grown-by-molecular-beam-epitaxy
#12
Yujing Ma, Sadhu Kolekar, Horacio Coy Diaz, Johannes Aprojanz, Ilio Miccoli, Christoph Tegenkamp, Matthias Batzill
Twin grain boundaries in MoSe2 are metallic and undergo a metal to insulator Peierls transition at low temperature. Growth of MoSe2 by molecular beam epitaxy results in the spontaneous formation of a high density of these twin grain boundaries, likely as a mechanism to incorporation Se-deficiency in the film. Using scanning tunneling microscopy, we study the grain boundary network that is formed in homoepitaxially grown MoSe2, and for MoSe2 grown heteroepitaxially on MoS2- and HOPG- substrates. No statistically relevant variation of the grain boundary concentration has been found for the different substrates, indicating that the grain boundary formation is substrate independent and depends mainly on the growth conditions...
April 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28453929/synthesis-of-lipophilic-core-shell-fe3o4-sio2-au-nanoparticles-and-polymeric-entrapment-into-nano-micelle-a-novel-nanosystem-for-in-vivo-active-targeting-and-magnetic-resonance-photoacoustic-dual-imaging
#13
Ilaria Monaco, Francesca Arena, Stefania Biffi, Erika Locatelli, Barbara Bortot, Francesca La Cava, Giada Maria Marini, Gian Maria Severini, Enzo Terreno, Mauro Comes Franchini
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthetized to obtain a promising theranostic platform. In order to improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles (PMs), decorated with folic acid moieties and tested in vivo for Photoacustic (PA) and MRI detection of ovarian cancer.
April 28, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28453886/remote-diagnosis-of-traumatic-dental-injuries-using-digital-photographs-captured-via-a-mobile-phone
#14
Rogério de Almeida Geraldino, Liliana Vicente Melo de Lucas Rezende, Cibele Queiroz da-Silva, Júlio César Franco Almeida
BACKGROUND: Intra-oral photographs has been aided diagnosis of several pathologies in teledentistry. Mobile phone cameras may produce high quality photographs, presenting itself as a viable tool for remote diagnosis of traumatic dental injuries. Aim To evaluate the levels of inter-examiner agreement in cases of traumatic dental injuries when comparing diagnoses conducted in person and remotely. MATERIAL AND METHODS: The sample included 40 patients with 73 traumatized teeth, and a total of 90 diagnoses, who had presented to two dental clinics, one private and the other public, in Brazil's Federal District...
April 28, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28453722/accuracy-of-mdct-and-cbct-in-three-dimensional-evaluation-of-the-oropharynx-morphology
#15
Hui Chen, Maureen van Eijnatten, Ghizlane Aarab, Tim Forouzanfar, Jan de Lange, Paul van der Stelt, Frank Lobbezoo, Jan Wolff
Objective: To assess the accuracy of five different computed tomography (CT) scanners for the evaluation of the oropharynx morphology. Methods: An existing cone-beam computed tomography (CBCT) data set was used to fabricate an anthropomorphic phantom of the upper airway volume that extended from the uvula to the epiglottis (oropharynx) with known dimensions (gold standard). This phantom was scanned using two multi-detector row computed tomography (MDCT) scanners (GE Discovery CT750 HD, Siemens Somatom Sensation) and three CBCT scanners (NewTom 5G, 3D Accuitomo 170, Vatech PaX Zenith 3D)...
April 27, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28453429/anti-microbial-coating-innovations-to-prevent-infectious-diseases-amici-cost-action-ca15114
#16
Colum P Dunne, Minna M Keinänen-Toivola, Anne Kahru, Birgit Teunissen, Hulya Olmez, Isabel Gouveia, Luis Melo, Kazimierz Murzyn, Martina Modic, Merja Ahonen, Pete Askew, Theofilos Papadopoulos, Christian Adlhart, Francy R L Crijns
Worldwide, millions of patients are affected annually by healthcare-associated infection (HCAI), impacting up to 80,000 patients in European Hospitals on any given day. This represents not only public health risk, but also an economic burden. Complementing routine hand hygiene practices, cleaning and disinfection, antimicrobial coatings hold promise based, in essence, on the application of materials and chemicals with persistent bactericidal or -static properties onto surfaces or in textiles used in healthcare environments...
April 28, 2017: Bioengineered
https://www.readbyqxmd.com/read/28449460/role-of-bronchoprovocation-tests-in-identifying-exercise-induced-bronchoconstriction-in-a-non-athletic-population-a-pilot-study
#17
Jessica H Y Tan, Wui Mei Chew, Therese S Lapperre, Gan Liang Tan, Chian Min Loo, Mariko S Koh
BACKGROUND: Studies on diagnostic tests for exercise-induced bronchoconstriction (EIB) have centered around the asthmatic and elite athletic population. Traditionally, the exercise challenge test (ET) was recommended to assess EIB. We aimed to compare the performance of surrogate testing, mainly the hypertonic saline (HS) test, and methacholine challenge test (MCT) versus ET in identifying EIB among non-athletic subjects. METHODS: We prospectively recruited subjects who did not have confirmed active asthma, but who reported exercise-induced dyspnoea...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448961/supported-binary-liposome-vesicle-gold-nanoparticle-for-enhanced-label-free-dna-and-protein-sensing
#18
Divya Karutha Pandian, Venkataraman Dharuman
Supported binary liposome mixture of cationic liposome N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium propane (DOTAP) and the zwitterionic liposome 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine (DOPE) were tethered on thiol monolayers in the absence and presence of gold nanoparticle to enhance sensor stability and sensitivity for label free DNA and protein sensing for the first time. Cysteamine hydrochloride (Cyst), 3-Mercaptopropionic acid (MPA), 11-Mercaptoundecanoic acid (MUDA) and 11-amino-1-undecane thiol (AUT) monolayers were used as tethers on gold surfaces...
April 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28448949/utility-of-the-fitbit-flex-to-evaluate-sleep-in-major-depressive-disorder-a-comparison-against-polysomnography-and-wrist-worn-actigraphy
#19
Jesse D Cook, Michael L Prairie, David T Plante
BACKGROUND: Sleep disturbance is a common and important component of affective illness. Fitness activity trackers are emerging as alternative means to estimate sleep in psychiatric patients; however, their ability to quantify sleep in mood disorders has not been empirically evaluated. Thus, this study sought to evaluate the utility of the Fitbit Flex (FBF) to estimate sleep in patients with major depressive disorder (MDD) relative to gold standard polysomnography (PSG) and a widely-used actigraph (Actiwatch-2; AW-2)...
April 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28448880/rapid-green-synthesis-of-gold-nanocatalyst-for-high-efficiency-degradation-of-quinclorac
#20
Guorong Shi, Yulu Li, Gaihong Xi, Qinqin Xu, Zijun He, Yating Liu, Jianhui Zhang, Jun Cai
Porous chemical pretreated Saccharomyces cerevisiae was used as support, stabilizer, and reducing agent for the rapid green synthesis of gold nanocatalyst. Au nanoparticles (Au NPs) were generated through in-situ reduction of the absorbed Au(III) by the reductive functional groups of mannoproteins in yeast cell wall. The obtained spherical mono-dispersed Au NPs have an average particle diameter of 9.99±1.63nm as evidenced by TEM image, and exhibits excellent catalytic activity for the dechlorination of quinclorac to 8-quinoline-carboxylic acid by sodium borohydride...
April 18, 2017: Journal of Hazardous Materials
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