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https://www.readbyqxmd.com/read/28545172/femoral-nerve-block-versus-adductor-canal-block-for-analgesia-after-total-knee-arthroplasty
#1
REVIEW
In Jun Koh, Young Jun Choi, Man Soo Kim, Hyun Jung Koh, Min Sung Kang, Yong In
Inadequate pain management after total knee arthroplasty (TKA) impedes recovery, increases the risk of postoperative complications, and results in patient dissatisfaction. Although the preemptive use of multimodal measures is currently considered the principle of pain management after TKA, no gold standard pain management protocol has been established. Peripheral nerve blocks have been used as part of a contemporary multimodal approach to pain control after TKA. Femoral nerve block (FNB) has excellent postoperative analgesia and is now a commonly used analgesic modality for TKA pain control...
June 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28545136/assessment-of-the-quantiferon-tb-gold-in-tube-test-for-the-detection-of-mycobacterium-tuberculosis-infection-in-united-states-navy-recruits
#2
Jason M Lempp, Margan J Zajdowicz, Arlene L Hankinson, Sean R Toney, Lisa W Keep, James D Mancuso, Gerald H Mazurek
BACKGROUND: Immunologic tests such as the tuberculin skin test (TST) and QuantiFERON®-TB Gold In-Tube test (QFT-GIT) are designed to detect Mycobacterium tuberculosis infection, both latent M. tuberculosis infection (LTBI) and infection manifesting as active tuberculosis disease (TB). These tests need high specificity to minimize unnecessary treatment and high sensitivity to allow maximum detection and prevention of TB. METHODS: Estimate QFT-GIT specificity, compare QFT-GIT and TST results, and assess factor associations with test discordance among U...
2017: PloS One
https://www.readbyqxmd.com/read/28545060/signet-a-signaling-network-data-simulator-to-enable-signaling-network-inference
#3
Elizabeth A Coker, Costas Mitsopoulos, Paul Workman, Bissan Al-Lazikani
Network models are widely used to describe complex signaling systems. Cellular wiring varies in different cellular contexts and numerous inference techniques have been developed to infer the structure of a network from experimental data of the network's behavior. To objectively identify which inference strategy is best suited to a specific network, a gold standard network and dataset are required. However, suitable datasets for benchmarking are difficult to find. Numerous tools exist that can simulate data for transcriptional networks, but these are of limited use for the study of signaling networks...
2017: PloS One
https://www.readbyqxmd.com/read/28545034/characterization-of-sudan-ebolavirus-infection-in-ferrets
#4
Andrea Kroeker, Shihua He, Marc-Antoine de La Vega, Gary Wong, Carissa Embury-Hyatt, Xiangguo Qiu
Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental compounds and should only be used to test the most promising candidates. Therefore, other smaller animal models are a valuable asset. We have recently developed a guinea-pig adapted SUDV virus that is lethal in guinea pigs...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544921/in-situ-formed-copper-nanoparticles-templated-by-tdt-mediated-dna-for-enhanced-spr-sensor-based-dna-assay
#5
Pei-Xin Yuan, Sheng-Yuan Deng, Chen-Yu Zheng, Serge Cosnier, Dan Shan
For the efficient surface plasmon resonance (SPR)-based DNA assay researching, signal amplification tactics were absolutely necessary. In this work, a sensitive SPR-DNA sensor was developed by employing in situ synthesis of copper nanoparticles (CuNPs) templated by poly-T sequences DNA from terminal deoxynucleotidyl transferase (TdT)-mediated extension, and synergistically with nano-effect deposition as the mass relay. The objective of this strategy was manifold: firstly, tDNA hybridized with the optimal designed probes to active the TdT-mediated DNA extension onto the surface of SPR chip, resulted a long poly-T sequences ssDNA chain in dsDNA terminal onto surface of gold chip and characterized by SPR signal amplitudes...
May 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28544766/barriers-and-facilitators-of-mentoring-for-trainees-and-early-career-investigators-in-rheumatology-research-current-state-identification-of-needs-and-roadmap-to-an-inter-institutional-adult-rheumatology-mentoring-program
#6
Alexis Ogdie, Jeffrey A Sparks, Sheila T Angeles-Han, Kathleen Bush, Flavia V Castelino, Amit Golding, Yihui Jiang, J Michelle Kahlenberg, Alfred H J Kim, Yvonne C Lee, Kirthi Machireddy, Michael J Ombrello, Ami A Shah, Zachary S Wallace, Peter A Nigrovic, Una E Makris
OBJECTIVES: Determine perceived barriers and facilitators to effective mentoring for early career rheumatology investigators and develop a framework for an inter-institutional mentoring program. METHODS: Focus groups or interviews with rheumatology fellows, junior faculty, and mentors were conducted, audiotaped and transcribed. Content analysis was performed using NVivo software. Themes were grouped into categories (e.g., mentor-mentee relationship, barriers and facilitators of a productive relationship)...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28544761/composites-of-bacterial-cellulose-and-small-molecule-decorated-gold-nanoparticles-for-treating-gram-negative-bacteria-infected-wounds
#7
Ying Li, Yue Tian, Wenshu Zheng, Yan Feng, Rong Huang, Jingxin Shao, Rongbing Tang, Peng Wang, Yuexiao Jia, Jiangjiang Zhang, Wenfu Zheng, Guang Yang, Xingyu Jiang
Bacterial infections, especially multidrug-resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram-negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility...
May 23, 2017: Small
https://www.readbyqxmd.com/read/28544757/eight-electron-silver-and-mixed-gold-silver-nanoclusters-stabilized-by-se-donor-ligands
#8
Wan-Ting Chang, Po-Yi Lee, Jian-Hong Liao, Samia Kahlal, Jean-Yves Saillard, Chen-Wei Liu
The first atomically and structurally precise silver-nanoclusters stabilized by Se-donor ligands, [Ag20{Se2P(OiPr)2}12] (3) and [Ag21{Se2P(OEt)2}12]+(4), have been isolated by ligand replacement reaction of [Ag20{S2P(OiPr)2}12] (1) and [Ag21{S2P(OiPr)2}12]+ (2), respectively. Further, doping reactions of 4 with Au(PPh3)Cl resulted in the formation of [AuAg20{Se2P(OEt)2}12]+, (5). Structures of 3, 4 and 5 were determined by single crystal X-ray diffraction. The anatomy of cluster 3 with an Ag20 core having C3 symmetry is very similar to that of its dithiophosphate analogue 1...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544742/gold-catalyzed-cadiot-chodkiewicz-type-cross-coupling-of-terminal-alkynes-with-alkynyl-hypervalent-iodine-reagents-highly-selective-synthesis-of-unsymmetrical-1-3-diynes
#9
Xiangdong Li, Xin Xie, Ning Sun, Yuanhong Liu
A new and efficient method for the synthesis of unsymmetrical 1,3-butadiynes by gold-catalyzed C(sp)-C(sp) cross-coupling of terminal alkynes with alkynyl hypervalent iodine(III) reagents has been developed. The reaction features high selectivity and efficiency, mild reaction conditions, wide substrate scope, and functional-group compatibility, and is a highly attractive complement to existing methods. Mechanistic studies reveal that formation of a phenanthrolinyl-ligated gold(I) complex is crucial for the efficiency and selectivity of the target transformation...
May 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544622/an-investigation-into-the-two-stage-meta-analytic-copula-modelling-approach-for-evaluating-time-to-event-surrogate-endpoints-which-comprise-of-one-or-more-events-of-interest
#10
Natalie Dimier, Susan Todd
Clinical trials of experimental treatments must be designed with primary endpoints that directly measure clinical benefit for patients. In many disease areas, the recognised gold standard primary endpoint can take many years to mature, leading to challenges in the conduct and quality of clinical studies. There is increasing interest in using shorter-term surrogate endpoints as substitutes for costly long-term clinical trial endpoints; such surrogates need to be selected according to biological plausibility, as well as the ability to reliably predict the unobserved treatment effect on the long-term endpoint...
May 19, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28544505/understanding-the-mechanisms-of-gold-shell-growth-onto-polymer-microcapsules-to-control-shell-thickness
#11
Alison Louise Tasker, James Hitchcock, Elaine Alice Baxter, Olivier Cayre, Simon Biggs
Polymer microcapsules have been used commercially for decades, however they have an inherent flaw which renders them impractical as a carrier of small, volatile molecules. The porous nature of the polymer shell allows for diffusion of the encapsulated molecules into the bulk. The use of metal shells is an innovative way to prevent undesired loss of small molecules from the core of microcapsules, however it is important, particularly when using expensive metals to ensure that the resulting shell is as thin as possible...
May 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28544497/cell-tracking-using-gold-nanoparticles-and-computed-tomography-imaging
#12
REVIEW
Rinat Meir, Rachela Popovtzer
Cell-based therapies utilize transplantation of living cells with therapeutic traits to alleviate numerous diseases and disorders. The use of such biological agents is an attractive alternative for diseases that existing medicine cannot effectively treat. Although very promising, translating cell therapy to the clinic has proven to be challenging, due to inconsistent results in preclinical and clinical studies. To examine the underlying cause for these inconsistencies, it is crucial to noninvasively monitor the accuracy of cell injection, and cell survival and migration patterns...
May 24, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28544447/modulation-of-wetting-gradients-by-tuning-the-interplay-between-surface-structuration-and-anisotropic-molecular-layers-with-bipolar-electrochemistry
#13
Laurent Bouffier, Stéphane Reculusa, Valérie Ravaine, Alexander Kuhn
A new simple and versatile method for the preparation of surface wetting gradients is proposed. It is based on the combination of electrode surface structuration introduced by a sacrificial template approach and the formation of a tuneable molecular gradient by bipolar electrochemistry. The gradient involves the formation of a self-assembled monolayer on gold surface by selecting an appropriate thiol molecule and the subsequent reductive desorption by means of bipolar electrochemistry. Under these conditions, the completion of the reductive desorption process evolves along the bipolar surface with a maximum strength localized at the cathodic edge and a decreasing driving force toward the middle of the surface...
May 22, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28544420/gold-i-hydrides-as-proton-acceptors-in-dihydrogen-bond-formation
#14
Ignacy Cukrowski, Jurgens Hendrik de Lange, Ferdinand Groenewald, Helgard G Raubenheimer
Wavefunction and DFT calculations indicate that anionic dihydride complexes of AuI form strong to moderate directed Au-H···H bonds with one or two HF, H₂O and NH₃ prototype proton donor molecules. The largely electrostatic interaction is influenced by relativistic effects which, however, do not increase the binding energy. Very weak Au···H associations - exhibiting a corresponding bond path - occur between neutral AuH and HF units, although ultimately F becomes the preferred donor atom in the most stable structure...
May 25, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28544392/growth-process-and-anti-cancer-properties-of-gold-nanorods
#15
Junyan Zhang, Mian Wang, Thomas J Webster
Gold nanoparticles have been of great interest due to their unique optical properties, facile synthesis and conjugation. Among various shapes of gold nanoparticles, gold nanorods have been widely studied. They can be conjugated with different molecules for biomedical applications, such as tumor imaging and therapy. However, few researchers have studied the anti-tumor properties of bare gold nanorods. In this study, unfunctionalized gold nanorods were synthesized and tested on breast tumor cells. Results showed that the aspect ratio of gold nanorods could be easily influenced by both reaction time and the amount of silver nitrate in the growth solution...
May 24, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28544306/high-fidelity-narcissistic-self-sorting-in-the-synthesis-of-organometallic-assemblies-from-poly-nhc-ligands
#16
Narayan Sinha, Tristan T Y Tan, Eduardo Peris, F Ekkehardt Hahn
Highly selective, narcissistic self-sorting has been observed in the one-pot synthesis of three organometallic molecular cylinders of type [M3 {L-(NHC)3 }2 ](PF6 )3 (M=Ag(+) , Au(+) ; L=1,3,5-benzene, triphenylamine, or 1,3,5-triphenylbenzene) from L-(NHC)3 and silver(I) or gold(I) ions. The molecular cylinders contain only one type of tris-NHC ligand with no crossover products detectable. Transmetalation of the tris-NHC ligands from Ag(+) to Au(+) in a one-pot reaction with retention of the supramolecular structures is also demonstrated...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28544304/strong-improvement-of-long-term-chemical-and-thermal-stability-of-plasmonic-silver-nanoantennas-and-films
#17
Xiaolong Wang, Christian Santschi, Olivier J F Martin
Silver (Ag) nanostructures and thin films are advantageous plasmonic materials as they have significantly lower losses than gold (Au). Unfortunately, Ag nanostructures suffer from poor chemical and thermal stability, which limit their applications. Here, the mechanisms leading to the deterioration of Ag nanostructures are clarified. It is first shown that oxygen alone cannot oxidize Ag nanostructures. Then, experiments using X-ray photoelectron spectroscopy reveal that the amount of sulfur in ambient air is too low for efficient tarnishing of the Ag surface...
May 24, 2017: Small
https://www.readbyqxmd.com/read/28544251/robotic-bariatric-surgery-a-general-review-of-the-current-status
#18
REVIEW
Minoa K Jung, Monika E Hagen, Nicolas C Buchs, Leo H Buehler, Philippe Morel
BACKGROUND: While conventional laparoscopy is the gold standard for almost all bariatric procedures, robotic assistance holds promise for facilitating complex surgeries and improving clinical outcomes. Since the report of the first robotic-assisted bariatric procedure in 1999, numerous publications, including those reporting comparative trials and meta-analyses across bariatric procedures with a focus on robotic assistance, can be found. PURPOSE: This article reviews the current literature and portrays the perspectives of robotic bariatric surgery...
May 23, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28544231/dual-responsive-molecular-switches-based-on-dithienylethene-ru-ii-organometallics-in-self-assembled-monolayers-operating-at-low-voltage
#19
Andrea Mulas, Xiaoyan He, Yves-Marie Hervault, Lucie Norel, Stéphane Rigaut, Corinne Lagrost
Two carbon-rich ruthenium complexes bearing a dithienylethene (DTE) unit and a hexylthiol spacer were designed to be attached on gold surfaces. Both compounds display photochemically-driven switching properties, allowing reversible conversion from open to closed forms of the DTE units upon irradiation in solution. In contrast, only the bimetallic complex undergoes an efficient electrochemical ring closure at low potential, (0.5 V vs SCE), whereas the monometallic complex show a simple one electron reversible redox event...
May 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28544222/usefulness-of-detection-of-clarithromycin-resistant-helicobacter-pylori-from-fecal-specimens-for-young-adults-treated-with-eradication-therapy
#20
Takako Osaki, Katsuhiro Mabe, Cynthia Zaman, Hideo Yonezawa, Masumi Okuda, Kenji Amagai, Shinji Fujieda, Mitsuhide Goto, Wataru Shibata, Mototsugu Kato, Shigeru Kamiya
BACKGROUND: To prevent Helicobacter pylori infection in the younger generation, it is necessary to investigate the prevalence of antibiotic-resistant H. pylori. OBJECTIVE: The aim of this study was to evaluate the method of PCR-based sequencing to detect clarithromycin (CAM) resistance-associated mutations using fecal samples as a noninvasive method. METHODS: DNA extracted from fecal specimens and isolates from gastric biopsy specimens were collected from patients with H...
May 22, 2017: Helicobacter
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