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https://www.readbyqxmd.com/read/29337862/therapeutic-management-of-pseudomonas-aeruginosa-bloodstream-infection-non-susceptible-to-carbapenems-but-susceptible-to-old-cephalosporins-and-or-to-penicillins
#1
Ronit Zaidenstein, Asaf Miller, Ruthy Tal-Jasper, Hadas Ofer-Friedman, Menachem Sklarz, David E Katz, Tsillia Lazarovitch, Paul R Lephart, Bethlehem Mengesha, Oran Tzuman, Mor Dadon, Chen Daniel, Jacob Moran-Gilad, Dror Marchaim
It is unknown as to whether other beta-lactams can be used for bloodstream infections (BSI) resulting from Pseudomonas aeruginosa (PA) which are non-susceptible to one or more carbapenem. We conducted a retrospective cohort study at the Assaf Harofeh Medical Center (AHMC) from January 2010 to August 2014. Adult patients with PA-BSI non-susceptible to a group 2 carbapenem but susceptible to ceftazidime or piperacillin (with or without tazobactam), were enrolled. We compared the outcomes of patients who received an appropriate beta-lactam antibiotic ("cases") to those who received an appropriate non-beta-lactam antibiotic ("controls")...
January 16, 2018: Microorganisms
https://www.readbyqxmd.com/read/29337626/comparative-analysis-of-pasteurella-multocida-isolates-from-acute-and-chronic-fowl-cholera-cases-in-hungary-during-the-period-2005-through-2010
#2
Boglárka Sellyei, Ákos Thuma, Dmitriy Volokhov, Zsuzsanna Varga
Fowl cholera (FC) is a highly contagious and economically important disease of poultry worldwide. This study was performed on 218 Pasteurella multocida isolates collected from separated breeding farms or backyards with acute and chronic FC cases in multiple localities across Hungary during the period 2005-2010. All isolates were characterized by a broad range of biochemical, serological, and molecular methods, as well as their antibiotic susceptibility to aminoglycosides (A), macrolides (M), penicillins (P), quinolones (Q), cephalosporins, sulphonamides (S), and tetracyclines (T) was determined...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29337085/disc-describing-infections-of-the-spine-treated-with-ceftaroline
#3
Richard R Watkins, George Yendewa, Steven D Burdette, Sophia Horattas, Nairmeen Awad Haller, Caroline Mangira, Robert A Salata, Robert A Bonomo
OBJECTIVES: Spine infections lead to considerable morbidity and high cost to the global health care system. Currently, the evidence for using ceftaroline, an advanced-generation cephalosporin active against methicillin-resistant Staphylococcus aureus (MRSA), in spine infections is limited. METHODS: Describing Infections of the Spine treated with Ceftaroline (DISC) is a multicenter retrospective cohort study that evaluated ceftaroline for treating spine infections...
January 11, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29333777/-retrospective-analysis-of-adverse-drug-reactions-in-stomatology-hospital-from-2014-to-2016
#4
Li Jia, Wang Jianli, Zhao Ke, Zhao Shaofeng
OBJECTIVE: This study aims to investigate the characteristics and general rules of adverse drug reactions (ADR) in a 3A-grade stomatology hospital for safe and rational drug use in clinical stomatology. METHODS: We retrospectively analyzed 52 ADR cases (1∶1.36, males∶females) reported in the West China Hospital of Stomatology of Sichuan University from 2014 to 2016 in terms of gender and age distributions, drug categories, and clinical manifestations. RESULTS: Eight kinds of drugs and antibiotics were predominately used [24 cases, 46...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29331005/pregnant-lady-with-undiagnosed-hodgkin-s-disease-presenting-as-secondary-sclerosing-cholangitis
#5
Taif Khattak, Syed Hashim Ali Shah, Waqas Khan, Syed Shahmeer Raza, Uzair Ahmad, Farhan Ullah
Hodgkin's lymphoma. A 25 years old lady, 34 weeks primigravida was referred from the Emergency Department to the Medical Unit Khyber Teaching Hospital-MTI, Peshawar with four weeks of fever, progressive jaundice, pruritus, night sweats and weight loss. LFTs showed cholestatic picture, ERCP showed scanty intrahepatic giving beading and autumn tree appearance typical of sclerosing cholangitis. CBD was normal. Doppler U/S of hepatic and portal vein reported normal. She was started on steroids, ursodeoxycholic acid and antibiotics 3rd generation cephalosporins to which she did not respond well...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29329519/eikenella-corrodens-endocarditis-and-liver-abscess-in-a-previously-healthy-male-a-case-report
#6
Anne Christine Nordholm, Ruth Ottilia Birgitta Vøgg, Henrik Permin, Terese Katzenstein
BACKGROUND: Eikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male. CASE PRESENTATION: A 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission there was elevated white blood cell count and C-reactive protein, as well as affected liver function tests...
January 12, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29329177/a-comparison-of-real-time-polymerase-chain-reaction-assays-for-the-detection-of-antimicrobial-resistance-markers-and-sequence-typing-from-clinical-nucleic-acid-amplification-test-samples-and-matched-neisseria-gonorrhoeae-culture
#7
Shelley W Peterson, Irene Martin, Walter Demczuk, Linda Hoang, John Wylie, Brigitte Lefebvre, Annie-Claude Labbé, Prenilla Naidu, David Haldane, Michael R Mulvey
Real-time polymerase chain reaction (PCR) assays to detect antimicrobial resistance-associated mutations were tested on Neisseria gonorrhoeae-positive clinical samples with matched isolates. Of the nucleic acid amplification tests/cultures, 87.7% (64/73), 98.6% (72/73), and 98.4% (62/63) predicted cephalosporin, ciprofloxacin, and azithromycin susceptibilities, respectively. N. gonorrhoeae multiantigen sequence type was correctly predicted for 98.7% (79/80), and 13 of 58 N. gonorrhoeae-negative specimens showed false-positive results...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29326806/negative-impact-of-prolonged-antibiotics-or-persistent-diarrhea-on-vitamin-k1-levels-in-2-24-weeks-aged-egyptian-infants
#8
Mohsen S Elalfy, Fatma S E Ebeid, Iman A Elagouza, Fatma A Ibrahim, Noura B M Hassan, Beshoy A Botros
Background: To evaluate the hazard of prolonged antibiotic therapy and/or persistent diarrhea on vitamin K1 (VK1) level and bleeding profile in infants (2-24 weeks). Methods: A one-year case-control study, conducted at Ain Shams University, Egypt. 338 infants (2-24 weeks) were recruited and divided into 3 groups (1:1:3 ratios); group A (n=67) patients who received antibiotics for ≥10 days, group B (n=67) who had persistent diarrhea ≥ 14 days and group C (n=204) age- and gender- matched infants who had not either received antibiotics nor had diarrhea...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29322236/-urosepsis
#9
Mathias W Pletz, Sebastian Weis, Christina Forstner, Florian Wagenlehner
Urosepsis is defined as a severe disease due to organ failure caused by a urinary tract infection. An empirical antibiotic therapy should be instigated within the first hour after diagnosis. Urine cultures and blood cultures should be performed before antibiotic treatment. Further diagnostics should be carried out at an early stage to enable an interventional focus control in the case of urinary tract obstruction or abscess formation, if necessary. Gram-negative pathogens are most frequently isolated. Extended spectrum beta-lactamase (ESBL) forming bacteria as a cause of urosepsis are increasing...
January 10, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29318906/cefiderocol-a-novel-siderophore-cephalosporin
#10
Justin J Choi, Matthew W McCarthy
The emergence of multidrug-resistant bacterial pathogens has led to a global public health emergency and novel therapeutic options and drug-delivery systems are urgently needed. Cefiderocol is a siderophore cephalosporin antibiotic that has recently been developed to combat a variety of bacterial pathogens, including β-lactam- and carbapenem-resistant organisms. Areas covered: This paper provides an overview of the mutational and plasmid-mediated mechanisms of β-lactam and carbapenem resistance, the biochemical pathways of siderophores in bacterial iron metabolism, and how cefiderocol may be able to provide better targeted antimicrobial therapy that escape these drug-resistant mechanisms...
January 10, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29318461/ceftriaxone-promotes-the-emergence-of-ampc-overproducing-enterobacteriaceae-in-gut-microbiota-from-hospitalized-patients
#11
Victoire de Lastours, Tiphaine Goulenok, François Guérin, Hervé Jacquier, Cindy Eyma, Françoise Chau, Vincent Cattoir, Bruno Fantin
Epidemiological data suggest that ceftriaxone may promote the emergence of commensal AmpC-overproducing Enterobacteriaceae because of a high biliary excretion. We tested this hypothesis in hospitalized patients either treated by ceftriaxone alone or receiving no antibiotics. Hospitalized patients with no previous antibiotics or hospitalization in the last 3 months, treated only with ceftriaxone, were prospectively included. For each ceftriaxone-treated patient, a control patient receiving no antibiotics was included...
January 10, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29318458/diagnostic-performance-of-blood-culture-bottles-for-vitreous-culture-compared-to-conventional-microbiological-cultures-in-patients-with-suspected-endophthalmitis
#12
Jan Kehrmann, Valerie Chapot, Jan Buer, Philipp Rating, Norbert Bornfeld, Joerg Steinmann
The purpose of this investigation was to evaluate the performance of blood culture bottles in comparison to conventional microbiological culture techniques in detecting causative microorganisms of endophthalmitis and to determine their anti-infective susceptibility profiles. All consecutive cases with clinically suspected endophthalmitis in a university-based ophthalmology department between January 2009 and December 2016 were analysed in this retrospective comparative case series. Samples from 247 patients with suspected endophthalmitis underwent microbiological diagnostic work-up...
January 9, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29316517/functional-metagenomics-reveals-a-novel-carbapenem-hydrolyzing-mobile-beta-lactamase-from-indian-river-sediments-contaminated-with-antibiotic-production-waste
#13
Nachiket P Marathe, Anders Janzon, Stathis D Kotsakis, Carl-Fredrik Flach, Mohammad Razavi, Fanny Berglund, Erik Kristiansson, D G Joakim Larsson
Evolution has provided environmental bacteria with a plethora of genes that give resistance to antibiotic compounds. Under anthropogenic selection pressures, some of these genes are believed to be recruited over time into pathogens by horizontal gene transfer. River sediment polluted with fluoroquinolones and other drugs discharged from bulk drug production in India constitute an environment with unprecedented, long-term antibiotic selection pressures. It is therefore plausible that previously unknown resistance genes have evolved and/or are promoted here...
January 6, 2018: Environment International
https://www.readbyqxmd.com/read/29313589/role-of-clarithromycin-in-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#14
Agam Vora
The prevalence of chronic obstructive pulmonary disease (COPD) is increasing in under-developing and developing countries. As per current estimations, COPD will become the third leading cause of death globally, by 2030. Long-acting anti-cholinergic agents, β2-agonists, inhaled corticosteroids, antibiotics and mucolytics are few of the agents currently used in the treatment of COPD, which improve the symptoms and overall quality of life. Several of the important classes of antibiotics are used in the management of COPD including penicillins, cephalosporins, tetracyclines, fluoroquinolones, sulphonamides, aminoglycosides and macrolides...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29311079/neisseria-cinerea-with-high-ceftriaxone-mic-is-an-origin-of-ceftriaxone-and-cefixime-resistance-mediating-pena-sequences-in-neisseria-gonorrhoeae
#15
Gene Igawa, Yuka Yamagishi, Ken-Ichi Lee, Misato Dorin, Ken Shimuta, Hiroyuki Suematsu, Shu-Ichi Nakayama, Hiroshige Mikamo, Magnus Unemo, Makoto Ohnishi
Mosaic penA alleles have caused most of the cephalosporin resistance in Neisseria gonorrhoeae, but their evolution is mostly unknown. The Neisseria cinerea strain AM1601 (ceftriaxone MIC=1.0 μg/ml) penA caused ceftriaxone resistance (MIC=1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3' -terminal half of AM1601 penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains. N. cinerea can serve as a reservoir of ceftriaxone resistance-mediating penA sequences that are transferred to gonococci...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29311072/pharmacokinetics-safety-and-tolerability-of-cefiderocol-a-novel-siderophore-cephalosporin-for-gram-negative-bacteria-in-healthy-subjects
#16
Yutaka Saisho, Takayuki Katsube, Scott White, Hiroyuki Fukase, Jingoro Shimada
Cefiderocol is a novel parenteral siderophore cephalosporin that shows potent efficacy against various Gram-negative bacteria, including carbapenem-resistant strains, in vitro and in preclinical models of infection. The aim of the present study was to evaluate the pharmacokinetics (PK), safety, and tolerability of cefiderocol after both single and multiple dosing by intravenous infusion over 60 min in healthy adult subjects. A single-ascending-dose study at doses of 100, 250, 500, 1000, and 2000 mg was conducted in 40 healthy Japanese males and females (six active and two placebo per cohort)...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310949/antibiotic-resistance-rates-for-pseudomonas-aeruginosa-clinical-respiratory-and-bloodstream-isolates-among-the-veterans-affairs-healthcare-system-from-2009-to-2013
#17
Haley J Appaneal, Aisling R Caffrey, Lan Jiang, David Dosa, Leonard A Mermel, Kerry L LaPlante
Pseudomonas aeruginosa is a major cause of healthcare-associated infections and resistance among isolates is an increasing burden. The study purpose was to describe national resistance rates for clinical P. aeruginosa respiratory and bloodstream cultures and the prevalence of multidrug-resistant (MDR) P. aeruginosa within the Veterans Affairs (VA). MDR was defined as non-susceptibility to at least one drug in at least 3 of the following 5 categories: carbapenems, extended-spectrum cephalosporins, aminoglycosides, and piperacillin/tazobactam...
December 6, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29304746/a-multi-center-study-on-the-risk-factors-of-infection-caused-by-multi-drug-resistant-acinetobacter-baumannii
#18
Huiping Huang, Borong Chen, Gang Liu, Jing Ran, Xianyu Lian, Xinhua Huang, Nan Wang, Zhengjie Huang
BACKGROUND: Acinetobacter baumannii (AB) is critical for healthcare-associated infections (HAI) with significant regional differences in the resistance rate, but its risk factors and infection trends has not been well studied. We aimed to explore the risk factors, epidemiological characteristics and resistance of multidrug-resistant Acinetobacter baumannii (MDR-AB) in intensive care unit inpatients. METHODS: Data of patients with MDR-AB (195 cases), and with antibiotic-sensitive AB infection (294 cases, control) during January to December, 2015 in three medical centers in Xiamen, China were conducted and analyzed in the present retrospective study...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29303883/are-third-generation-cephalosporins-still-the-empirical-antibiotic-treatment-of-community-acquired-spontaneous-bacterial-peritonitis-a-systematic-review-and-meta-analysis
#19
Marco Fiore, Ivan Gentile, Alberto E Maraolo, Sebastiano Leone, Vittorio Simeon, Paolo Chiodini, Maria C Pace, Thierry Gustot, Fabio S Taccone
BACKGROUND: Spontaneous bacterial peritonitis (SBP) is a common complication among cirrhotic patients. Guidelines recommend third-generation cephalosporins (3GCs) as empiric antibiotic therapy (EAT) of SBP. Recently, a broad-spectrum EAT was shown to be more effective than cephalosporins in the treatment of nosocomial spontaneous bacterial peritonitis (N-SBP); however, the prevalence of 3GCs-resistant bacteria is high in the nosocomial setting and broad-spectrum EAT cannot be used in all cases of SBP...
January 4, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29298481/modeling-the-transient-kinetics-of-the-l1-metallo-%C3%AE-lactamase
#20
Maria G Khrenova, Alexander V Nemukhin
The transient absorption spectroscopy of hydrolysis of the chromogenic substrate nitrocefin by the L1 metallo-β-lactamase (MβL), a bacterial enzyme responsible for destruction of β-lactam antibiotics molecules, showed formation and decay of a plausible red-shifted reaction intermediate. We propose a mechanism of this important reaction consistent with the transient kinetic data. Quantum mechanics/molecular mechanics (QM/MM) simulations of the reaction pathway revealed occurrence of two reaction intermediates (I1, I2) between the enzyme-substrate (ES) and enzyme-product (EP) complexes...
January 3, 2018: Journal of Physical Chemistry. B
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