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https://www.readbyqxmd.com/read/28535640/-study-of-diffusion-weighted-imaging-in-combination-with-conventional-mri-signs-for-inflammation-activity-of-chronic-hepatitis-b
#1
H W Ren, H Y Ye, W M An, J H Dong, Y Liu
Objective: To study the correlation between ADC values of diffusion weighted imaging (DWI) and the pathological grading in inflammation activity of chronic hepatitis B, and combined with conventional MRI features to predict the diagnosis effectiveness. Methods: A total of 142 cases of patients with chronic hepatitis B were selected as inflammatory group in 302 Hospital of PLA from January 2014 to December 2015, while 20 cases of healthy subjects without history of liver disease were chosen as control group...
May 23, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28522112/diffuse-parenchymal-lung-disease-on-chest-radiographs-and-ct
#2
Theodore J Dubinsky, Hardik Shah, Rachelle Sonneborn, Daniel S Hippe
BACKGROUND: We prospectively identified B-lines in patients undergoing ultrasound examinations following liver transplants who also had a chest x-ray (CXR) and/or chest CT scan on the same day to determine if an association between the presence of B-lines s from the thorax on ultrasound images correlates with the presence of pulmonary abnormalities on chest radiographs. MATERIALS AND METHODS: Following IRB approval, patients undergoing routine postoperative liver transplant ultrasound examinations and a CXR and/or CT scan on the same day between 1/1/2015 through 7/1/2016 were prospectively identified...
May 15, 2017: Chest
https://www.readbyqxmd.com/read/28516225/a-case-of-bilateral-keratitis-caused-by-providencia-alcalifaciens-a-rarely-encountered-ocular-pathogen
#3
Won Choi, Yong Sok Ji, Kyung Chul Yoon
PURPOSE: To report a case of keratitis caused by Providencia alcalifaciens. METHODS: A 70-year-old man presented with pain, redness, and decreased vision in both of his eyes. On initial presentation, the visual acuity in both of his eyes was hand motion, and slit lamp examination showed diffuse infiltrates and total epithelial defects of the cornea, conjunctival hyperemia, and severe anterior chamber reactions with 2-mm-height hypopyon. The results of laboratory studies revealed elevated liver function tests, which indicated the presence of alcoholic liver disease...
May 17, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28498108/imaging-for-abdominal-involvement-in-amyloidosis
#4
H Nursun Özcan, Mithat Haliloğlu, Cenk Sökmensüer, Deniz Akata, Mustafa Özmen, Muşturay Karçaaltıncaba
Involvement of the abdominal organs has variable presentations mostly without specific findings. The objective of this pictorial was to illustrate the computed tomography (CT) and magnetic resonance imaging (MRI) findings of abdominal involvement in systemic amyloidosis. Heterogeneous appearance of the liver, periportal involvement, diffuse low signal intensity of spleen on T2-weighted MRI, and thickened bowel wall may be helpful imaging findings when accompanied by presence or history of chronic inflammatory disease and clinical suspicion for amyloidosis...
May 12, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28494271/motion-robust-parameter-estimation-in-abdominal-diffusion-weighted-mri-by-simultaneous-image-registration-and-model-estimation
#5
Sila Kurugol, Moti Freiman, Onur Afacan, Liran Domachevsky, Jeannette M Perez-Rossello, Michael J Callahan, Simon K Warfield
Quantitative body DW-MRI can detect abdominal abnormalities as well as monitor response-to-therapy for applications including cancer and inflammatory bowel disease with increased accuracy. Parameter estimates are obtained by fitting a forward model of DW-MRI signal decay to the observed data acquired with several b-values. The DW-MRI signal decay models typically used do not account for respiratory, cardiac and peristaltic motion, however, which may deteriorate the accuracy and robustness of parameter estimates...
May 3, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28493097/gastric-adenosquamous-carcinoma-producing-granulocyte-colony-stimulating-factor-a-case-of-a-rare-malignancy
#6
Kazuki Moro, Masayuki Nagahashi, Tetsuya Naito, Yu Nagai, Tomohiro Katada, Masahiro Minagawa, Jun Hasegawa, Tatsuo Tani, Naohiro Shimakage, Hiroyuki Usuda, Emmanuel Gabriel, Tsutomu Kawaguchi, Kazuaki Takabe, Toshifumi Wakai
BACKGROUND: A gastric adenosquamous carcinoma (ASC) that produces granulocyte-colony stimulating factor (G-CSF) is an uncommon malignancy with a poor prognosis. Due to the rarity of this lesion, a standard treatment for the disease has not been established. CASE PRESENTATION: We describe a case of a 66-year-old male with a G-CSF-producing gastric ASC who presented with severe anemia and leukocytosis. A radical resection was performed, followed by a course of adjuvant chemotherapy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28487601/is-there-still-a-role-for-the-hepatic-locoregional-treatment-of-metastatic-neuroendocrine-tumors-in-the-era-of-systemic-targeted-therapies
#7
EDITORIAL
Federica Cavalcoli, Emanuele Rausa, Dario Conte, Antonio Federico Nicolini, Sara Massironi
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) frequently present with distant metastases at the time of diagnosis and the liver is the most frequent site of spreading. The early identification of metastatic disease represents a major prognostic factor for GEP-NENs patients. Radical surgical resection, which is feasible for a minority of patients, is considered the only curative option, while the best management for patients with unresectable liver metastases is still being debated. In the last few years, a number of locoregional and systemic treatments has become available for GEP-NEN patients metastatic to the liver...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28480679/relationship-between-non-alcoholic-fatty-liver-disease-and-breast-cancer
#8
William Nseir, Zuhair Abu-Rahmeh, Alex Tsipis, Julnar Mograbi, Mahmud Mahamid
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease which refers to the presence of hepatic steatosis. Breast cancer is now the most common cancer in women and is the leading cause of death from cancer among women. OBJECTIVES: To assess the relationship between NAFLD and newly diagnosed cases of breast cancer. METHODS: The results of mammography screening examinations in women referred to the Breast Center, Holy Family Hospital, Nazareth during a 4 year period were collected...
April 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28480609/pancreatic-neuroendocrine-tumor-correlations-between-mri-features-tumor-biology-and-clinical-outcome-after-surgery
#9
Rodrigo Canellas, Grace Lo, Sreejita Bhowmik, Cristina Ferrone, Dushyant Sahani
PURPOSE: To assess which magnetic resonance imaging (MRI) features are associated with pNETs (pancreatic neuroendocrine tumors) grade based on the WHO classification, as well as identify MRI features related to disease progression after surgery. MATERIALS AND METHODS: In this Institutional Review Board (IRB)-approved study, 1.5T and 3.0T MRI scans of 80 patients with surgically verified pNETs were assessed. The images were evaluated for tumor location; size; pattern; predominant signal intensity on precontrast T1 - and T2 -weighted images, as well as on postcontrast arterial and portal venous phase T1 -weighted sequences; presence of pancreatic duct dilatation; pancreatic atrophy; restricted diffusion; vascular involvement by the tumor; extrapancreatic tumor spread; and synchronous liver metastases...
May 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28465872/a-rare-cause-of-portal-hypertension-behcet-s-disease-and-nodular-regenerative-hyperplasia-of-the-liver
#10
Cyriac Philips, Rajaguru Paramaguru, Lijesh Kumar, Padmanabha Shenoy, Philip Augustine
Nodular regenerative hyperplasia (NRH) is a rare liver condition in which widespread benign transformation of the hepatic parenchyma into small regenerative nodules occur, leading to development of non-cirrhotic portal hypertension. Conditions associated with NRH include rheumatologic, hematological, autoimmune, infectious, neoplastic, or drug-related etiology. Accurate diagnosis is made on liver biopsy, showing diffuse micronodular transformation in the absence of fibrosis. Here, we present the second case in world literature of a middle-aged man presenting with recent onset sleep reversal and memory loss with darkening of skin for four years associated with systemic manifestations, in whom porto-systemic shunt syndrome due to NRH secondary to Behcet's disease was eventually diagnosed...
March 29, 2017: Curēus
https://www.readbyqxmd.com/read/28452094/imaging-characteristics-of-liver-langerhans-cell-histiocytosis-in-children
#11
Hui Liu, Xueying Long, Xiaoyi Wang, Wenzheng Li, Yigang Pei
BACKGROUND: Hepatic involvement of Langerhans cell histiocytosis (LCH) in children is important not only for prognostic purposes, but also as a guide for therapeutic strategies. The purpose of this study was to evaluate the imaging characteristics of hepatic LCH by computed tomography (CT) and magnetic resonance imaging (MRI) in children. METHODS: Imaging features of 17 children with hepatic LCH diagnosed by physical examination, laboratory and histopathological tests were analyzed retrospectively...
April 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28445298/barcelona-clinic-liver-cancer-stage-c-hepatocellular-carcinoma-a-novel-approach-to-subclassification-and-treatment
#12
Chung Hwan Jun, Jae Hyun Yoon, Eunae Cho, Sang Soo Shin, Sung Bum Cho, Hee Joon Kim, Chang Hwan Park, Hyun Soon Kim, Sung Kyu Choi, Jong Sun Rew
Barcelona clinic liver cancer-stage C (BCLC-C) encompasses a broad spectrum of tumor burdens, liver function statuses, patient prognoses, and treatment strategies. Currently, sorafenib is the only recommended treatment for patients with BCLC-C and outcomes remain suboptimal. The aims of this study were to assess the heterogeneity of BCLC-C hepatocellular carcinoma (HCC) cases, propose a novel subclassification for these cases, and suggest optimal treatment strategies other than sorafenib.We retrospectively analyzed 196 consecutive BCLC-C HCC patients who were diagnosed and treated between January 2008 and December 2015...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28431402/micrometastasis-of-endometriosis-to-distant-organs-in-a-murine-model
#13
Elham N Samani, Ramanaiah Mamillapalli, Fei Li, Levent Mutlu, Demetra Hufnagel, Graciela Krikun, Hugh S Taylor
Endometriosis is an inflammatory gynecological disorder among reproductive-aged women caused by the engraftment and proliferation of endometrial cells outside the uterus, most commonly in the pelvis. It is thought that the disease arises primarily from retrograde menstruation where cells from the endometrium travel through the fallopian tubes to the peritoneal cavity. However, migration of endometriosis-derived cells to distant organs outside of the peritoneal cavity have not been explored. In the present study, we developed and validated a mouse model of disseminated endometriosis using syngeneic DsRed endometrial tissue introduced into the peritoneum of immunocompetent mice...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414662/weil-s-disease-from-a-local-new-orleans-bar
#14
H P Kahn, L Bateman
INTRODUCTION: Leptospirosis is a zoonotic infection that typically presents with fever, myalgias, nausea, and vomiting after contact with contaminated waters or infected animals (typically rodents); and their excrements. Conditions favorable to the transmission of leptospirosis are common in LA and, without treatment, leptospirosis can lead to both liver and renal failure, meningitis, pulmonary hemorrhage and ultimately death. CASE: A 56 year old woman with no past medical history presented to the Emergency Department with weakness, myalgias, jaundice and decreased urine output for one week...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28409533/control-of-oxygen-tension-recapitulates-zone-specific-functions-in-human-liver-microphysiology-systems
#15
Felipe T Lee-Montiel, Subin M George, Albert H Gough, Anup D Sharma, Juanfang Wu, Richard DeBiasio, Lawrence A Vernetti, D Lansing Taylor
This article describes our next generation human Liver Acinus MicroPhysiology System (LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 microenvironments can be established by controlling the oxygen tension in individual devices over the range of ca. 3 to 13%. The oxygen tension was computationally modeled using input on the microfluidic device dimensions, numbers of cells, oxygen consumption rates of hepatocytes, the diffusion coefficients of oxygen in different materials and the flow rate of media in the MicroPhysiology System (MPS)...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28407756/alpha-fetoprotein-elevation-in-nut-midline-carcinoma-a-case-report
#16
Lorenzo D'Ambrosio, Erica Palesandro, Marina Moretti, Giuseppe Pelosi, Alessandra Fabbri, Fabrizio Carnevale Schianca, Massimo Aglietta, Giovanni Grignani
BACKGROUND: Nuclear protein in testis (NUT) midline carcinoma is a rarely diagnosed and potentially under-recognized type of squamous carcinoma that is considered one of the most aggressive human solid tumors. Alpha-fetoprotein elevation has been associated with chronic liver diseases and a limited number of cancers. In particular, in presence of a mediastinal mass in a young man, alpha-fetoprotein elevation is considered nearly pathognomonic of a non-seminoma germ-cell tumor. CASE PRESENTATION: A 22-year old man without any comorbidity was diagnosed with a large mediastinal mass with skeletal and lymph node metastases...
April 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28407655/efsumb-guidelines-and-recommendations-on-the-clinical-use-of-liver-ultrasound-elastography-update-2017-long-version
#17
Christoph F Dietrich, Jeffrey Bamber, Annalisa Berzigotti, Simona Bota, Vito Cantisani, Laurent Castera, David Cosgrove, Giovanna Ferraioli, Mireen Friedrich-Rust, Odd Helge Gilja, Ruediger Stephan Goertz, Thomas Karlas, Robert de Knegt, Victor de Ledinghen, Fabio Piscaglia, Bogdan Procopet, Adrian Saftoiu, Paul S Sidhu, Ioan Sporea, Maja Thiele
We present here the first update of the 2013 EFSUMB (European Federation of Societies for Ultrasound in Medicine and Biology) Guidelines and Recommendations on the clinical use of elastography, focused on the assessment of diffuse liver disease. The first part (long version) of these Guidelines and Recommendations deals with the basic principles of elastography and provides an update of how the technology has changed. The practical advantages and disadvantages associated with each of the techniques are described, and guidance is provided regarding optimization of scanning technique, image display, image interpretation, reporting of data and some of the known image artefacts...
April 13, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28407654/efsumb-guidelines-and-recommendations-on-the-clinical-use-of-liver-ultrasound-elastography-update-2017-short-version
#18
Christoph F Dietrich, Jeffrey Bamber, Annalisa Berzigotti, Simona Bota, Vito Cantisani, Laurent Castera, David Cosgrove, Giovanna Ferraioli, Mireen Friedrich-Rust, Odd Helge Gilja, Ruediger Stephan Goertz, Thomas Karlas, Robert de Knegt, Victor de Ledinghen, Fabio Piscaglia, Bogdan Procopet, Adrian Saftoiu, Paul S Sidhu, Ioan Sporea, Maja Thiele
We present here the first update of the 2013 EFSUMB (European Federation of Societies for Ultrasound in Medicine and Biology) Guidelines and Recommendations on the clinical use of elastography with a focus on the assessment of diffuse liver disease. The short version provides clinical information about the practical use of elastography equipment and interpretation of results in the assessment of diffuse liver disease and analyzes the main findings based on published studies, stressing the evidence from meta-analyses...
April 13, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28386718/globus-pallidus-mr-signal-abnormalities-in-children-with-chronic-liver-disease-and-or-porto-systemic-shunting
#19
Sylviane Hanquinet, Claire Morice, Delphine S Courvoisier, Vladimir Cousin, Mehrak Anooshiravani, Laura Merlini, Valérie A McLin
OBJECTIVES: Detection of subclinical hepatic encephalopathy in children is difficult. We aimed to assess the changes in imaging of the central nervous system in children with chronic liver disease using MR imaging, diffusion, and (1)H -spectroscopy. METHODS: Forty three children with chronic liver disease and/or porto-systemic shunting (111.4±56.9 months) and 24 controls (72.0±51.8 months) underwent brain MRI/spectroscopy on a 1.5T to examine T1, T2, ADC, Cho/Cr, ml/Cr, Glx/Cr ratio spectroscopy in the globus pallidus...
April 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28382841/hepatocellular-carcinoma-in-fanconi-bickel-syndrome
#20
Jennifer Pogoriler, Allison F O'Neill, Stephan D Voss, Robert C Shamberger, Antonio R Perez-Atayde
Fanconi-Bickel syndrome is a rare autosomal recessive disorder due to mutations in the facilitative glucose transporter 2 ( GLUT2 or SLC2A2) gene resulting in excessive glycogen storage predominantly in the liver and kidney. Previous case reports of this condition have described liver biopsies with glycogen storage and variable steatosis and/or fibrosis. Unlike in other types of glycogen storage disease, hepatocellular adenomas and carcinomas have not been described to date in this syndrome. A 6-year-old boy with consanguineous parents had short stature, poorly controlled rickets, hepatosplenomegaly, and renal tubular dysfunction clinically consistent with Fanconi-Bickel Syndrome...
January 1, 2017: Pediatric and Developmental Pathology
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