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https://www.readbyqxmd.com/read/27932149/portal-vein-inflow-from-enlarged-coronary-vein-in-liver-transplantation-surgical-approach-and-technical-tips-a-case-report
#1
M Safwan, S Nagai, M S Abouljoud
Portal vein thrombosis is common in patients with end-stage liver disease, with an incidence as high as 26% in liver transplant candidates. It is known to be associated with a high risk of morbidity and mortality posttransplantation, and its management can be challenging. The management options range from a simple thrombendvenectomy to multivisceral transplantation in cases with diffuse portomesenteric thrombosis. We report a case of liver transplantation in which we performed a rare reconstruction of the portal vein...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27929457/advanced-animal-model-of-colorectal-metastasis-in-liver-imaging-techniques-and-properties-of-metastatic-clones
#2
Go Oshima, Melinda E Stack, Sean C Wightman, Darren Bryan, Elizabeth Poli, Lai Xue, Kinga B Skowron, Abhineet Uppal, Sean P Pitroda, Xiaona Huang, Mitchell C Posner, Samuel Hellman, Ralph R Weichselbaum, Nikolai N Khodarev
Patients with a limited number of hepatic metastases and slow rates of progression can be successfully treated with local treatment approaches(1,2). However, little is known about the heterogeneity of liver metastases, and animal models capable of evaluating the development of individual metastatic colonies are needed. Here, we present an advanced model of hepatic metastases that provides the ability to quantitatively visualize the development of individual tumor clones in the liver and estimate their growth kinetics and colonization efficiency...
November 30, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27921168/the-2016-diagnostic-criteria-for-primary-sclerosing-cholangitis
#3
Takahiro Nakazawa, Kenji Notohara, Susumu Tazuma, Atsushi Tanaka, Hiroyuki Isayama, Toshio Tsuyuguchi, Toshiyuki Mori, Hajime Takikawa
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown cause that is characterized pathologically by an inflammatory and fibrotic process centered on the epithelium, leading to diffuse biliary stenosis and increased wall thickness throughout the intra- and extra-hepatic biliary trees. A nationwide survey in Japan revealed several differences in the clinical aspects of PSC between Japan and Western countries. PSC was recently designated an intractable hepatobiliary disease in Japan...
December 5, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27913210/trpv4-activation-of-endothelial-nitric-oxide-synthase-resists-nonalcoholic-fatty-liver-disease-by-blocking-cyp2e1-mediated-redox-toxicity
#4
Ratanesh K Seth, Suvarthi Das, Diptadip Dattaroy, Varun Chandrashekaran, Firas Alhasson, Gregory Michelotti, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Darwin P Bell, Wolfgang Liedtke, Saurabh Chatterjee
NAFLD is a clinically progressive disease with steatosis, inflammation, endothelial dysfunction and fibrosis being the stages where clinical intervention becomes necessary. Lack of early biomarkers and absence of a FDA approved drug obstructs efforts for effective treatment. NAFLD progression is strongly linked to a balance between liver injury, tissue regeneration and the functioning of endogenous defense mechanisms. The failure of the defense pathways to resist the tissue damage arising from redox stress, one of the "multiple hits" in disease progression, give rise to heightened inflammation and occasional fibrosis...
November 29, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27906428/the-epidemiology-of-non-alcoholic-fatty-liver-disease-and-its-connection-with-cardiovascular-disease-role-of-endothelial-dysfunction
#5
A Federico, M Dallio, M Masarone, M Persico, C Loguercio
The non-alcoholic fatty liver disease is considered a predominant hepatopathy worldwide and a component of metabolic syndrome. It represents a risk factor for the development of cardiovascular diseases, independently of the presence of diabetes mellitus, hypertension and obesity. For this reason, nowadays an epidemiological analysis and a research of the causes that correlate non-alcoholic fatty liver disease and cardiovascular pathologies, are extremely useful. There are important epidemiological variations in relation to various geographical areas, and depending on different population groups, the prevalence of this pathology changes...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27881610/primary-leiomyosarcoma-of-the-ovarian-vein-case-report-and-literature-review
#6
María Elena López-Ruiz, Laura Yébenes, Alberto Berjón, David Hardisson
Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relation to the left ovary. The patient subsequently underwent a total hysterectomy with bilateral salpingo-oophorectomy. Histologically, the tumor was composed of interlacing fascicles of spindle cells with abundant eosinophilic cytoplasm, hyperchromatic nuclei, and prominent nucleoli...
November 23, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27862590/hepatic-gadoxetic-acid-uptake-as-a-measure-of-diffuse-liver-disease-where-are-we
#7
REVIEW
Ahmed Ba-Ssalamah, Nina Bastati, Andreas Wibmer, Romana Fragner, Jacqueline C Hodge, Michael Trauner, Christian J Herold, Mustafa R Bashir, Bernard E Van Beers
: MRI has emerged as the most comprehensive noninvasive diagnostic tool for focal liver lesions and diffuse hepatobiliary disorders. The introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI, particularly in the functional imaging of chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD). GA-enhanced MRI (GA-MRI) may help to distinguish between the two subgroups of NAFLD, simple steatosis and nonalcoholic steatohepatitis...
November 8, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27847518/adult-onset-still-s-disease-associated-with-mycoplasma-pneumoniae-infection-and-hemophagocytic-lymphohistiocytosis
#8
Abhishek Agnihotri, Allison Ruff, Lauren Gotterer, Addie Walker, Amy H McKenney, Andrei Brateanu
Adult Onset Still's Disease (AOSD) is a systemic inflammatory disorder that can be associated with hemophagocytic lymphohistiocytosis (HLH), a rare but potentially fatal disease of overactive histiocytes and lymphocytes. We present a unique case of AOSD complicated by Mycoplasma pneumonia infection and HLH. A 28-year-old female developed joint pains followed by a diffuse, erythematous, pruritic skin rash that quickly spread throughout the body. The patient deteriorated and developed fever, chills, cough, and dyspnea and had to be intubated...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27843428/a-rare-case-of-gastric-variceal-hemorrhage-secondary-to-infiltrative-b-cell-lymphoma
#9
Adrienne Lenhart, Juan Fernandez-Castillo, Keith Mullins, Reena Salgia
Portal hypertension commonly arises in the setting of advanced liver cirrhosis and is the consequence of increased resistance within the portal vasculature. Less commonly, left-sided noncirrhotic portal hypertension can develop in a patient secondary to isolated obstruction of the splenic vein. We present a rare case of left-sided portal hypertension and isolated gastric varices in a patient with large B-cell lymphoma, who was treated with splenic artery embolization. The patient is a 73-year-old male with no previous history of liver disease, who presented with coffee ground emesis and melena...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27835979/pharmacologically-active-flavonoids-from-the-anticancer-antioxidant-and-antimicrobial-extracts-of-cassia-angustifolia-vahl
#10
Shabina Ishtiaq Ahmed, Muhammad Qasim Hayat, Muhammad Tahir, Qaisar Mansoor, Muhammad Ismail, Kristen Keck, Robert B Bates
BACKGROUND: Cassia angustifolia Vahl. (commonly known as senna makkai or cassia senna), native to Saudi Arabia, Egypt, Yemen and also extensively cultivated in Pakistan, is a medicinal herb used traditionally to cure number of diseases like liver diseases, constipation, typhoid, cholera etc. This study was conducted to evaluate the in-vitro antimicrobial, antioxidant and anticancer assays and phytochemical constituents of aqueous and organic extracts of C. angustifolia leaves. METHODS: The antimicrobial activities of C...
November 11, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27833517/clinical-utility-of-esophageal-manometry-in-the-patients-with-dysphagia-experience-from-sudan
#11
Amin M Abbas, Sami Medani, Tajeldin M Abdallah, Gasim I Gasim
OBJECTIVES: The aim of this study was to assess the clinical utility of esophageal manometry among Sudanese patients presenting to the National Centre for Gastrointestinal and Liver Diseases, Ibn Sina Hospital, Khartoum, Sudan. METHODOLOGY: Consecutive patients referred for esophageal manometry at the aforementioned center from July 2008 through January 2011 were included in the study. Manometric studies were done after stopping medicines with a known effect on esophageal motility and an overnight fast...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27830559/microencapsulation-of-hepatocytes-and-mesenchymal-stem-cells-for-therapeutic-applications
#12
Raphael P H Meier, Elisa Montanari, Philippe Morel, Joël Pimenta, Henk-Jan Schuurman, Christine Wandrey, Sandrine Gerber-Lemaire, Redouan Mahou, Leo H Bühler
Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semipermeable alginate-based hydrogels. Microspheres protect cells against antibodies and immune cells, while allowing nutrients, small/medium size proteins and drugs to diffuse inside and outside the polymer matrix. Microencapsulated cells are assessed in vitro and designed for experimental transplantation and for future clinical applications...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27829402/intracystic-magnetic-resonance-imaging-in-patients-with-autosomal-dominant-polycystic-kidney-disease-features-of-severe-cyst-infection-in-a-case-control-study
#13
Tatsuya Suwabe, Yoshifumi Ubara, Toshiharu Ueno, Noriko Hayami, Junichi Hoshino, Aya Imafuku, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Satoshi Saitoh, Itsuko Okuda, Kenmei Takaichi
BACKGROUND: The purpose of this study was to investigate the usefulness of intracystic MRI features for detection of severe cyst infection that is usually refractory to antibiotic therapy alone in patients with autosomal dominant polycystic kidney disease. METHODS: Seventy-six patients (88 episodes) with positive cyst cultures treated from January 2006 to December 2013 were enrolled as the cases for this case-control study, while 147 patients who continued to attend our hospital from January 2011 to December 2013 and did not have cyst infection diagnosed during that period were enrolled as the controls...
November 9, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27815224/minimal-hepatic-encephalopathy-in-children-with-chronic-liver-disease-prevalence-pathogenesis-and-magnetic-resonance-based-diagnosis
#14
Anshu Srivastava, Saurabh Chaturvedi, Rakesh Kumar Gupta, Rohan Malik, Amrita Mathias, Naranamangalam R Jagannathan, Sunil Jain, Chandra Mani Pandey, Surender Kumar Yachha, Ram Kishor Singh Rathore
BACKGROUND AND AIMS: Data on minimal hepatic encephalopathy (MHE) in children is scanty. We evaluated children with chronic liver disease (CLD) to determine prevalence of MHE, its correlation with changes in brain metabolites by magnetic resonance spectroscopy ((1)HMRS), diffusion tensor imaging (DTI) derived metrics, blood ammonia (BA) and inflammatory cytokines and the accuracy of MR based investigations for diagnosis METHODS: 67(38 boys; age 13[7-18] years) CLD and 37 healthy children were evaluated with neuropsychological tests (NPT), BA, interleukin-6 [IL6], tumor necrosis factor alpha [TNFα], magnetic resonance imaging (MRI),(1)HMRS and DTI...
November 1, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27812769/use-of-non-invasive-imaging-to-monitor-response-to-aflibercept-treatment-in-murine-models-of-colorectal-cancer-liver-metastases
#15
Karianne G Fleten, Kine M Bakke, Gunhild M Mælandsmo, Andreas Abildgaard, Kathrine Røe Redalen, Kjersti Flatmark
The liver is the most frequent metastatic site in colorectal cancer (CRC), and relevant orthotopic in vivo models are needed to study the efficacy of anticancer drugs in the metastatic setting. A challenge when utilizing such models is monitoring tumor growth during the experiments. In this study, experimental liver metastases were established in nude mice by splenic injection of the CRC cell lines HT29 and HCT116, and the mice were treated with the antiangiogenic drug aflibercept. Tumor growth was monitored using magnetic resonance imaging (MRI) and bioluminescence imaging (BLI)...
November 3, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27805533/lung-biopsy-findings-of-patients-who-have-undergone-a-liver-and-kidney-transplant
#16
Gonca Özgün, Merih Tepeoğlu, Binnaz Handan Özdemir, Eda Yılmaz Akçay, Ebru Şebnem Ayva, Emine Ebru Deniz, Mehmet Haberal
OBJECTIVES: Our objective was to analyze the incidence of pulmonary disorders in solid-organ transplant recipients and report on outcomes in these patients. MATERIALS AND METHODS: Seventy liver and kidney transplant patients, who underwent lung biopsy because of pulmonary symptoms between January 2000 and December 2015, were enrolled in the study. We examined and evaluated histopathologic findings of these patients based on clinical data recorded in patients' files...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27798786/response-monitoring-with-18-f-flt-pet-and-diffusion-weighted-mri-after-cytotoxic-5-fu-treatment-in-an-experimental-rat-model-for-colorectal-liver-metastases
#17
Sandra Heskamp, Linda Heijmen, Danny Gerrits, Janneke D M Molkenboer-Kuenen, Edwin G W Ter Voert, Kathrin Heinzmann, Davina J Honess, Donna-Michelle Smith, John R Griffiths, Sabrina Doblas, Ralph Sinkus, Peter Laverman, Wim J G Oyen, Arend Heerschap, Otto C Boerman
PURPOSE: The aim of the study was to investigate the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) and 3'-dexoy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) as early biomarkers of treatment response of 5-fluorouracil (5-FU) in a syngeneic rat model of colorectal cancer liver metastases. PROCEDURES: Wag/Rij rats with intrahepatic syngeneic CC531 tumors were treated with 5-FU (15, 30, or 60 mg/kg in weekly intervals)...
October 31, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27788034/hepatic-fibrosis-inflammation-and-steatosis-influence-on-the-mr-viscoelastic-and-diffusion-parameters-in-patients-with-chronic-liver-disease
#18
Helena S Leitão, Sabrina Doblas, Philippe Garteiser, Gaspard d'Assignies, Valérie Paradis, Feryel Mouri, Carlos F G C Geraldes, Maxime Ronot, Bernard E Van Beers
Purpose To determine the relationship of liver fibrosis, inflammation, and steatosis with the magnetic resonance (MR) viscoelastic and diffusion parameters in patients with chronic liver disease and to compare the diagnostic accuracy of the imaging parameters in staging liver fibrosis. Materials and Methods Consecutive patients with chronic liver disease scheduled for liver biopsy were prospectively recruited from November 2010 to October 2012 for this institutional review board-approved study after they provided written informed consent...
October 27, 2016: Radiology
https://www.readbyqxmd.com/read/27777894/pulmonary-manifestations-among-patients-with-primary-biliary-cirrhosis
#19
Deniz Koksal, Aydin Seref Koksal, Ahmet Gurakar
Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic liver disease caused by diffuse inflammation, destruction and fibrosis of the intrahepatic bile ducts, ultimately leading to cirrhosis, portal hypertension and liver failure. The pathogenesis of PBC is incompletely understood, but current data suggest roles for genetic susceptibility and environmental factors. PBC is often thought of as an organ-specific autoimmune disease, which mainly targets the liver; however, lung tissue is also a site for autoimmune involvement of PBC...
September 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/27766631/pulmonary-dysfunction-in-thalassaemia-major-is-there-any-relationship-with-body-iron-stores
#20
Francesca Guidotti, Gioia Piatti, Alessia Marcon, Elena Cassinerio, Marianna Giuditta, Alberto Roghi, Valter Fasano, Dario Consonni, Maria Domenica Cappellini
Although pulmonary function abnormalities in thalassaemia major (TM) were described in 1980, the pathogenetic mechanism is not clear and data are contradictory, probably because of study heterogeneity and the multifactorial nature of the pathogenesis. We retrospectively analysed 73 adult TM patients to evaluate the prevalence of pulmonary dysfunction in adult TM and investigate relationships with iron load. All patients underwent body plethysmography and carbon monoxide diffusion (DLCO) was assessed in 63, in addition to blood tests, echocardiogram and T2* myocardial and liver magnetic resonance imaging...
October 21, 2016: British Journal of Haematology
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