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Candida denture

Andrés Felipe Cartagena, Luís Antonio Esmerino, Rogerio Polak-Junior, Sibelli Olivieri Parreiras, Milton Domingos Michél, Paulo Vitor Farago, Nara Hellen Campanha
OBJECTIVE: The purpose of this study was to develop a new oral drug delivery system by incorporating polymeric miconazole nitrate (MN) microparticles on an experimental antifungal denture adhesive (DA). METHODS: Spray drying Eudragit L-100 (E) and Gantrez MS-955 (G) MN-microparticles were incorporated in DA. DAE1, DAG1, DAEG1, DAE2, DAG2, DAEG2 groups were obtained from the combination of polymers used in MN-microparticles (E, G and EG) and concentration of MN into DA (1, for 1% and 2, for 2%)...
October 10, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Juliana Hotta, Wilson Gustavo Cral, Vinicius Tatsuyuji Sakima, Vanessa Soares Lara, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek
BACKGROUND: Antifungal agents incorporated into temporary denture resilient liners as drug carries and delivery have been suggested as an alternative treatment for denture stomatitis. However, to test the in vivo biocompatibility of this protocol, standardization of an intraoral device for optimal drug delivery is required. OBJECTIVE: Standardized criteria were produced to adjust an acrylic intraoral device (IOD) for rats feasible for denture stomatitis treatment by sustained drug-delivery based on minimal inhibitory drug concentrations (MICs) of antifungals for Candida albicans biofilm...
October 13, 2016: Current Drug Delivery
Ayşegül Köroğlu, Onur Şahin, Doğu Ömür Dede, Şule Tuğba Deniz, Nurdan Karacan Sever, Serkan Özkan
This study investigated the effect of denture cleansers on the surface roughness and Candida albicans adherence of surface sealant agent coupled denture base resins. One hundred and twenty specimens were fabricated from 2 polymethyl methacrylate (PMMA) (Meliodent; Acron MC) and 1 polyamide (Deflex) denture base materials, coated with a sealant agent (Palaseal) and divided into 4 groups (n=10) according to overnight cleaning procedures: distilled water (control), 5% sodium hypochlorite (NaOCl) and two different sodium perborate (Corega; Rapident)...
2016: Dental Materials Journal
Elisenda Martori, Raúl Ayuso-Montero, Eva Willaert, Miguel Viñas, Maria Peraire, Jordi Martinez-Gomis
PURPOSE: Colonization by Candida is related to wearing a denture. How denture type, status, and maintenance play a role in determining Candida colonization remains unknown. This work evaluated removable denture status in an elderly population and explored the association between denture-related factors and oral Candida colonization as determined by systemic and local factors. MATERIALS AND METHODS: Socio-demographic, general health, and behavioral data and oral factors were registered by means of a questionnaire...
October 6, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Manatsu Kuraji, Tomonori Matsuno, Tazuko Satoh
Oral dryness, a serious problem for the aging Japanese society, is induced by aging-related hyposalivation and causes dysphagia, dysgeusia, inadaptation of dentures, and growth of oral Candida albicans. Oxidative stress clearly plays a role in decreasing saliva secretion and treatment with antioxidants such astaxanthin supplements may be beneficial. Therefore, we evaluated the effects of astaxanthin on the oral saliva secretory function of aging mice. The saliva flow increased in astaxanthin-treated mice 72 weeks after administration while that of the control decreased by half...
September 2016: Journal of Clinical Biochemistry and Nutrition
Jung-Hwan Lee, Ahmed El-Fiqi, Jeong-Ki Jo, Dong-Ae Kim, Si-Chul Kim, Soo-Kyung Jun, Hae-Won Kim, Hae-Hyoung Lee
OBJECTIVE: Poly(methyl methacrylate) (PMMA) used as removable denture bases or orthodontic appliances has relatively poor antimicrobial properties, which accelerate oral infection and induce unfavorable odors. Mesoporous silica nanoparticles (MSNs) have been highlighted as a potential additive to overcome this issue because of their drug-loading capacity. Here, we present the long-term antimicrobial effect of MSN-incorporated PMMA with drug-loading capacity. METHODS: After the MSNs were characterized, MSN incorporation into chemically activated PMMA (0...
September 23, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Duygu Karakis, Canan Akay, Burcin Oncul, Abbas Y Rad, Arife Dogan
The aim of the present study was to compare the effects of some disinfectants, including ethanol extract of propolis (EEP), on the adhesion of Candida albicans to denture base resins. Seventy-two acrylic resin samples were prepared, half of which was polished and the other half was roughened. C. albicans strain ATCC 10231 was incubated on Sabouraud dextrose agar (SDA) at 37°C for 48 h. The adhesion period was completed by keeping the cells in this suspension for 90 min at 37°C. Specimens were then immersed in the following solutions: 1%, 2%, and 5% sodium hypochlorite; 4% chlorhexidine gluconate; and 10% EEP...
2016: Journal of Oral Science
Subhajit Gantait, Jayanta Bhattacharyya, Samiran Das, Shibendu Biswas, Amit Ghati, Soumitra Ghosh, Preeti Goel
CONTEXT: This study evaluated the efficacy of denture adhesive, cleanser, chlorhexidine, and brushing against Candida albicans biofilm developed on an acrylic surface and predicted the most effective, simple, and inexpensive way to maintain denture health, thereby preventing denture stomatitis. AIMS: To find the best possible method for maintaining denture hygiene. SETTINGS AND DESIGN: This retrospective analysis was conducted in the Guru Nanak Institute of Dental Sciences and Research, Kolkata, and this in vitro study was designed to minimize denture stomatitis among denture wearing population...
July 2016: Contemporary Clinical Dentistry
M Lydia Rajakumari, P Saravana Kumari
OBJECTIVES: The aim of the present study was to determine the prevalence of Candida in the buccal cavity of diabetic and non-diabetic individuals in and around Pondicherry, India and to analyse the antifungal susceptibility profile of the selected isolates. MATERIALS AND METHODS: A total of 400 buccal samples, 200 each from diabetic and non-diabetic healthy individuals were included in the study. Sabouraud's dextrose agar was used for isolation of Candida species...
September 2, 2016: Journal de Mycologie Médicale
Aysegul Kurt, Gonca Erkose-Genc, Meltem Uzun, Tuğrul Sarı, Gulbahar Isik-Ozkol
PURPOSE: To evaluate the antimicrobial efficiency of three cleaning solutions and their effect on the physical properties of a denture base material. MATERIALS AND METHODS: A heat-cured polymethyl-methacrylate (PMMA) denture base material (Meliodent) and three cleaning solutions (alkaline-peroxide, 30 minutes; 1% sodium-hypochlorite, 10 minutes; and 0.1% polymeric-guanidine solution, 5 minutes) were used. For antifungal activity test, 40 disc-shaped specimens were fabricated and allocated into a control group (distilled water) and 3 experimental groups (n = 10) according to the cleaning solutions...
September 6, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
D Przybyłowska, K Piskorska, M Gołaś, M Sikora, E Swoboda-Kopeć, J Kostrzewa-Janicka, E Mierzwińska-Nastalska
Yeast-like fungi and gram-negative bacilli are the most frequent potential pathogens of the respiratory tract isolated from the denture plaque of patients with chronic obstructive pulmonary disease (COPD). Dominant species among yeast-like fungi are Candida albicans and Candida tropicalis. Significant frequency is also exhibited by Klebsiella pneumoniae and Klebsiella oxytoca. The purpose of this study was to analyze genetic diversity of the strains of C. albicans, C. tropicalis, and Klebsiella spp. present in patients in stable phases of COPD...
August 30, 2016: Advances in Experimental Medicine and Biology
Arjuna N B Ellepola, L P Samaranayake, Z U Khan
OBJECTIVE: Candida albicans is the primary causative agent of oral candidosis, and one of its key virulent attributes is considered to be its ability to produce extracellular phospholipases that facilitate cellular invasion. Oral candidosis can be treated with polyenes, and azoles, and the more recently introduced echinocandins. However, once administered, the intraoral concentration of these drugs tend to be sub-therapeutic and rather transient due to factors such as the diluent effect of saliva and cleansing effect of the oral musculature...
October 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Beatriz Helena Dias Panariello, Fernanda Emiko Izumida, Eduardo Buozi Moffa, Ana Claudia Pavarina, Janaina Habib Jorge, Eunive Teresinha Giampaolo
PURPOSE: To investigate the efficacy of immersion and brushing with different cleansing agents in reducing the viability of multispecies biofilm on acrylic resins. METHODS: Lucitone 550 (L) and Tokuyama Rebase Fast II (T) specimens (10 x 2 mm) were prepared, sterilized, and inoculated with a suspension of Candida albicans, Candida glabrata, and Streptococcus mutans. Specimens were incubated for 48 hours at 37 degrees C for biofilm formation. Then, they were divided into groups (n = 12) and subjected to brushing or immersion for 10 seconds in distilled water (W), 0...
June 2016: American Journal of Dentistry
Flávia Cristina Targa Coimbra, Marcela Moreira Salles, Viviane Cássia De Oliveira, Ana Paula Macedo, Cláudia Helena Lovato Da Silva, Valéria Oliveira Pagnano, Helena de Freitas Oliveira Paranhos
PURPOSE: To evaluate the in vitro antimicrobial efficacy of alkaline peroxides against microbial biofilms on acrylic resin surfaces. METHODS: Denture base acrylic resin (Lucitone 550; n= 360) circular specimens (15 x 3 mm) were obtained from a circular metal matrix and sterilized with microwave irradiation (650 W, 6 minutes). The specimens were then contaminated with suspensions [106 colony-forming units (CFU)/mL] of Candida albicans (Ca), Candida glabrata (Cg), Staphylococcus aureus (Sa), Streptococcus mutans (Sm), Bacillus subtilis (Bs), Enterococcus faecalis (Ef), Escherichia coli (Ec), and Pseudomonas aeruginosa (Pa)...
June 2016: American Journal of Dentistry
Seshagiri Muttagi, Jyothi Keralapura Subramanya
STATEMENT OF PROBLEM: The colonization of Candida albicans on soft liners causes the deterioration of material surface properties and denture stomatitis. PURPOSE: The purpose of this in vitro study was to investigate the effect of incorporating seed oil on the antifungal properties, surface roughness, wettability, weight changes, and glucose adsorption/absorption of a soft liner. MATERIAL AND METHODS: Centratherum anthelminticum, Ocimum sanctum Linn, and Linum usitatissimum seed oils were incorporated into a soft liner, and the diameter of the inhibition zone (DIZ) was calculated relative to the growth of C albicans at 24, 48, and 72 hours and 7 days...
August 1, 2016: Journal of Prosthetic Dentistry
Junko Yano, Alika Yu, Paul L Fidel, Mairi C Noverr
Denture stomatitis (DS) is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. The disease is caused by Candida albicans, which readily colonizes and form biofilms on denture materials. While evidence for biofilms on abiotic and biotic surfaces initiating Candida infections is accumulating, a role for biofilms in DS remains unclear. Using an established model of DS in immunocompetent animals, the purpose of this study was to determine the role of biofilm formation in mucosal damage during pathogenesis using C...
2016: PloS One
Petrus L B Madeira, Letícia T Carvalho, Marco A B Paschoal, Eduardo M de Sousa, Eduardo B Moffa, Marcos A Dos Santos da Silva, Rudys de Jesus Rodolfo Tavarez, Letícia M Gonçalves
The purpose of this study was to investigate whether immersion of a denture surface in lemongrass extract (LGE) has effects on C. albicans biofilms, human cell viability and denture surface. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) were performed for LGE against C. albicans. For biofilm analysis, discs were fabricated using a denture acrylic resin with surface roughness standardization. C. albicans biofilms were developed on saliva-coated discs, and the effects of LGE at MIC, 5XMIC, and 10XMIC were investigated during biofilm formation and after biofilm maturation...
2016: Frontiers in Cellular and Infection Microbiology
Mariusz Cierech, Jacek Wojnarowicz, Dariusz Szmigiel, Bohdan Bączkowski, Anna Maria Grudniak, Krystyna Izabela Wolska, Witold Łojkowski, Elżbieta Mierzwińska-Nastalska
PURPOSE: The aim of the paper was to investigate the antifungal activity of zinc oxide nanoparticles (ZnONPs) against Candida albicans. Some attempts have been made to find out the best way to introduce ZnONPs into polymethyl methacrylate (PMMA) resin material and to determine some parameters of a newly formed composite. MATERIAL AND METHODS: Zinc oxide nanoparticles were manufactured and their basic physical parameters were determined (average particle size, density, specific surface area)...
2016: Acta of Bioengineering and Biomechanics
Keke Zhang, Biao Ren, Xuedong Zhou, Hockin H K Xu, Yu Chen, Qi Han, Bolei Li, Michael D Weir, Mingyun Li, Mingye Feng, Lei Cheng
Our aims of the research were to study the antimicrobial effect of dimethylaminododecyl methacrylate (DMADDM) modified denture base resin on multi-species biofilms and the biocompatibility of this modified dental material. Candida albicans (C. albicans), Streptococcus mutans (S. mutans), Streptococcus sanguinis (S. sanguinis), as well as Actinomyces naeslundii (A. naeslundii) were used for biofilm formation on denture base resin. Colony forming unit (CFU) counts, microbial viability staining, and 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) array were used to evaluate the antimicrobial effect of DMADDM...
2016: International Journal of Molecular Sciences
Kae Harada-Hada, Sumiyo Mimura, Guang Hong, Tatsumi Hashida, Hitoshi Abekura, Hiroshi Murata, Masahiro Nishimura, Hiroki Nikawa
PURPOSE: Studies of effective methods for the easy removal of denture adhesives from a denture base are not well represented in the literature. We previously assessed the removability of denture adhesives by immersing within denture cleaners, showing that some cleaners have a weak effect, insufficiently effective in daily use. In this study, we prepared a cellulase, as a potential component for denture adhesive removers, and we examined whether the addition of cellulase to denture cleaners is effective in the removal of cream denture adhesives...
June 27, 2016: Journal of Prosthodontic Research
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