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https://www.readbyqxmd.com/read/28818264/the-potential-management-of-oral-candidiasis-using-anti-biofilm-therapies
#1
Warren Chanda, Thomson P Joseph, Wendong Wang, Arshad A Padhiar, Mintao Zhong
Candida albicans is a minor component of the oral microbiota and an opportunistic pathogen that takes advantage of the immunocompromised host and causes oral mucositis and oral candidiasis. This organism is able to undergo phenotypic modification from a yeast to hyphae growth phase, one of the key arsenals for immune cell evasion, tissue invasion and biofilm formation. The latter property coupled with overgrowth and immune compromising factors such as HIV/AIDS, cancer treatments, organ transplantation, diabetes, corticosteroid use, dentures, and broad-spectrum antibiotic use have modified the fungus from a normal component of the microflora to a foe of an oral cavity and resulting in reduced sensitivity towards commonly utilised antifungal agents...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28814859/inhibitory-effect-of-zirconium-oxide-nanoparticles-on-candida-albicans-adhesion-to-repaired-polymethyl-methacrylate-denture-bases-and-interim-removable-prostheses-a-new-approach-for-denture-stomatitis-prevention
#2
Mohammed M Gad, Ahmad M Al-Thobity, Suliman Y Shahin, Badar T Alsaqer, Aiman A Ali
BACKGROUND: Despite drawbacks, cold-cured acrylic resin is still the most common material used in denture repair. Zirconia nanoparticles were among the reinforcements added to increase the strength of the resin. The effect on Candida due to the addition of zirconia nanoparticles to the resin has not been investigated. PURPOSE: The aim of this study was to evaluate the effect of zirconia nanoparticles added to cold-cured acrylic resin on Candida albicans adhesion...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28772791/heat-polymerized-resin-containing-dimethylaminododecyl-methacrylate-inhibits-candida-albicans-biofilm
#3
Hui Chen, Qi Han, Xuedong Zhou, Keke Zhang, Suping Wang, Hockin H K Xu, Michael D Weir, Mingye Feng, Mingyun Li, Xian Peng, Biao Ren, Lei Cheng
The prevalence of stomatitis, especially caused by Candida albicans, has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (w/w). Flexure strength, bond quality, surface charge density, and surface roughness were measured to evaluate the physical properties of resin...
April 20, 2017: Materials
https://www.readbyqxmd.com/read/28698449/in-vitro-evaluation-of-the-inhibitory-activity-of-thymoquinone-in-combatting-candida-albicans-in-denture-stomatitis-prevention
#4
Ahmad M Al-Thobity, Khalifa S Al-Khalifa, Mohammed M Gad, Mohammed Al-Hariri, Aiman A Ali, Talal Alnassar
Candida albicans adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against Candida albicans. Eighty acrylic resin specimens were fabricated and divided into eight groups (n = 10) according to thymoquinone concentrations of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, and 5% of acrylic powder. Two methods were used to evaluate the effect of thymoquinone on Candida albicans: the slide count and the serial dilution test...
July 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28691453/the-effect-of-enriching-denture-adhesives-with-chlorhexidine-diacetate-on-the-proliferation-of-candida-albicans-an-in-vitro-analysis
#5
S Matalon, G Frydman, D Lauritano, H Slutzky, E Shlomo, S Levartovsky, F Carinci, Z Ormianer
Denture adhesives are widely used in dentistry. The growth of Candida albicans on the denture base is common on both jaws, particularly in elderly patients. A strong correlation has been found between the growth of Candida albicans and dentures, potentially leading to denture stomatitis. Recent studies show that the addition of chlorhexidine diacetate (CHDA) to denture adhesives can have a protective effect against denture stomatitis. The aim of this research is to examine the antifungal properties of three denture adhesives when CHDA is added...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28685534/oral-candida-carriage-and-species-prevalence-in-denture-stomatitis-patients-with-and-without-diabetes
#6
REVIEW
F Javed, A A Al-Kheraif, S V Kellesarian, F Vohra, G E Romanos
The objective of this study was to assess the oral Candida carriage and species prevalence in denture stomatitis (DS) patients with and without diabetes mellitus (DM). To address the focused question “In patients receiving dentures, how does having diabetes compared to no diabetes influences the carriage and species prevalence of oral Candida?” Indexed databases were explored without time or language restrictions up to and including February 2017. Nine studies were included. In these studies, the number of diabetics ranged between 14 patients and 405 individuals with mean ages ranging between 33 years and 66...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28678945/phagocytosis-and-nitric-oxide-production-by-peritoneal-adherent-cells-in-response-to-candida-albicans-in-aging-a-collaboration-to-elucidate-the-pathogenesis-of-denture-stomatitis
#7
Taiane Priscila Gardizani, Karen Henriette Pinke, Heliton Gustavo de Lima, Vanessa Soares Lara
Objective: The aim of this study was to investigate the influence of aging on the internalization and the production of nitric oxide (NO) by peritoneal adherent cells (PAC), in response to Candida albicans (C. albicans). Material and methods: PAC obtained from young and aged mice were challenged with dead or viable C. albicans by using predetermined proportions (cells:yeast) for 30 and 120 minutes. Phagocytosis was analyzed by acridine orange dye, and NO production by the Griess reaction...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28674706/the-effect-of-treatment-of-denture-related-stomatitis-on-peripheral-t-cells-and-monocytes
#8
Joanna Maciąg, Tomasz Mikołajczyk, Paweł Matusik, Daniel Nowakowski, Douglas Robertson, Anna Maciąg, Grzegorz Osmenda, Marta Cześnikiewicz-Guzik
PURPOSE: Systemic immune activation has been recently linked to chronic inflammatory disorders of the oral cavity, particularly to periodontitis. The purpose of this study was to determine whether treatment of a fungus-induced oral inflammation, namely denture-related stomatitis (DRS), can affect the activation of the systemic immune response. MATERIALS AND METHODS: Peripheral blood from patients with denture-related stomatitis caused by Candida albicans infection (n = 15) was collected at three time points: before treatment with nystatin, at the end of therapy and 2 months after finishing therapy...
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28658918/efficacy-of-neem-extract-and-three-antimicrobial-agents-incorporated-into-tissue-conditioner-in-inhibiting-the-growth-of-c-albicans-and-s-mutans
#9
Dikshita Ray Barua, Jayaprakash Mugur Basavanna, Rana Kalappattil Varghese
INTRODUCTION: Denture stomatitis is an inflammatory condition which compromises the mucosal surface beneath dentures. The aetiology of denture stomatitis is usually multifactorial which varies from trauma from ill fitting denture to poor immune system. There are evidences that denture stomatitis is an outcome of multispecies biofilms that include Candida albicans and Streptococcus mutans. Tissue conditioners are found to be more susceptible to colonisation by micro-organisms. AIM: The purpose of this study was to compare the efficacy of neem leaf extract and three other antimicrobial agents incorporated in a tissue conditioner against both Candida albicans and Streptococcus mutans...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28655563/pathogenic-characteristics-of-candida-albicans-isolated-from-oral-cavities-of-denture-wearers-and-cancer-patients-wearing-oral-prostheses
#10
J V Mothibe, M Patel
Candida albicans cause opportunistic infections including oral candidiasis in immunocompromised patients. It has an ability to cause infection due to its virulence factors. This study investigated the pathogenic characteristics of C. albicans isolated from the oral cavities of healthy subjects and two vulnerable groups, denture wearers and cancer patients wearing oral prostheses. Oral rinse samples were collected and cultured for the quantitative and qualitative analysis of Candida. Twenty strains of C. albicans isolated from the healthy individuals and denture wearers and, 14 strains isolated from the cancer patients were selected and their pathogenic characteristics were measured...
June 24, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28598524/nicotine-upregulates-coaggregation-of-candida-albicans-and-streptococcus-mutans
#11
Ali Ashkanane, Grace F Gomez, John Levon, L Jack Windsor, George J Eckert, Richard L Gregory
PURPOSE: Denture stomatitis is a condition of painless inflammation of denture-bearing mucosa. Reports indicate that nicotine, the major psychoactive ingredient in tobacco, increases growth of Streptococcus mutans and Candida albicans in denture biofilm. The purpose of this study was to determine the in vitro effects of nicotine on coaggregation of C. albicans with S. mutans. MATERIAL AND METHODS: C. albicans strain ATCC 10231, S. mutans strain UA159 (ATTC 700610), and nicotine dilutions (ranging from 0 to 32 mg/ml) were used for this study...
June 9, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28578870/the-essential-oil-of-allium-sativum-as-an-alternative-agent-against-candida-isolated-from-dental-prostheses
#12
Alejandro Mendoza-Juache, Saray Aranda-Romo, Josué R Bermeo-Escalona, Araceli Gómez-Hernández, Amaury Pozos-Guillén, Luis Octavio Sánchez-Vargas
BACKGROUND: The colonization of the surfaces of dental prostheses by Candida albicans is associated with the development of denture stomatitis. In this context, the use of fluconazole has been proposed, but its disadvantage is microbial resistance. Meanwhile, the oil of Allium sativum has shown an effect in controlling biofilm formation by C. albicans. AIMS: The objective of this study was to determine the antifungal activities of the essential oil of A. sativum and fluconazole against clinical isolates of Candida species obtained from rigid, acrylic-based partial or total dentures and to compare these agents' effects on both biofilm and planktonic cells...
July 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28575640/the-effect-of-subinhibitory-concentrations-of-gentian-violet-on-the-germ-tube-formation-by-candida-albicans-and-its-adherence-to-oral-epithelial-cells
#13
T Mafojane, S L Shangase, M Patel
OBJECTIVE: This study investigated the effect of subinhibitory concentrations of gentian violet on the germ tube formation by Candida albicans and its adherence ability to oral epithelial cells. METHODS: Thirty strains of C. albicans isolated from denture wearers, normal healthy individuals and HIV positive patients were used in the study. The antifungal property (Minimum Fungicidal Concentration) of gentian violet was determined at various time intervals using a microdilution technique...
May 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28552288/fabrication-of-denture-base-materials-with-antimicrobial-properties
#14
Aysan Mirizadeh, Mohammad Atai, Sirous Ebrahimi
STATEMENT OF PROBLEM: Acrylic resin denture base resins are colonized by oral and nonoral bacteria and Candida species. This reservoir of microorganism causes denture stomatitis, which can be implicated in some life-threating infections in older denture wearers. PURPOSE: The purpose of this in vitro study was to incorporate quaternized N,N-dimethylaminoethyl methacrylate (DMAEMA) monomer into a denture base resin and investigate its antimicrobial and mechanical properties...
May 26, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28539095/effectiveness-of-non-fluoride-and-fluoride-dentifrices-for-denture-hygiene
#15
Gökçe Meriç, Meryem Güvenir, Kaya Suer
OBJECTIVE: To compare the effectiveness of commonly used herbal/non-fluoride with fluoride dentifrices in order to eliminate pathogenic oral microorganisms from denture base material. MATERIALS AND METHODS: Heat-polymerized acrylic resin specimens (n = 288) were divided into three groups and each group inoculated with three various microorganisms (n = 96 for each) Candida albicans, Staphylococcus aureus and Pseudomonas aeruginosa (P. aeruginosa). Contaminated specimens were randomly assigned to the application of six herbal/non-fluoride and three fluoride dentifrices...
May 24, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28526091/a-pre-therapeutic-coating-for-medical-devices-that-prevents-the-attachment-of-candida-albicans
#16
Diego Vargas-Blanco, Aung Lynn, Jonah Rosch, Rony Noreldin, Anthony Salerni, Christopher Lambert, Reeta P Rao
BACKGROUND: Hospital acquired fungal infections are defined as "never events"-medical errors that should never have happened. Systemic Candida albicans infections results in 30-50% mortality rates. Typically, adhesion to abiotic medical devices and implants initiates such infections. Efficient adhesion initiates formation of aggressive biofilms that are difficult to treat. Therefore, inhibitors of adhesion are important for drug development and likely to have a broad spectrum efficacy against many fungal pathogens...
May 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28493889/characterization-of-a-novel-antibiofilm-effect-of-nitric-oxide-releasing-aspirin-ncx-4040-on-candida-albicans-isolates-from-denture-stomatitis-patients
#17
Francisco Madariaga-Venegas, Roberto Fernández-Soto, Luisa Fernanda Duarte, Nicole Suarez, Daniela Delgadillo, José A Jara, Ricardo Fernández-Ramires, Blanca Urzúa, Alfredo Molina-Berríos
Candida albicans biofilms play a key role in denture stomatitis, one of the most common oral pathologies in elderly people. Because biofilms are highly resistant to antifungals, new pharmacological strategies are needed. Aspirin and nitric oxide-donor molecules have both shown antibiofilm effects on C. albicans, making them promising candidates for treatment. In this study, we evaluated the antifungal/antibiofilm effect of a nitric-oxide releasing aspirin (NO-ASA) on C. albicans isolates from denture stomatitis patients in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28492744/surface-properties-of-temporary-soft-liners-modified-by-minimum-inhibitory-concentrations-of-antifungals
#18
Mírian Galvão Bueno, Elen Juliana Bonassa de Sousa, Juliana Hotta, Vinícius Carvalho Porto, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek
Evaluating the addition of minimum inhibitory concentrations (MICs) of antifungals for Candida albicans biofilm on the hardness and roughness of temporary denture soft liners. Specimens (n=8; 36×7×6 mm) of tissue conditioner (Softone) and resilient liner (Trusoft) were produced either without (control) or with incorporation of drugs at MICs: nystatin (0.032 g/mL), chlorhexidine diacetate (0.064 g/mL), ketoconazole (0.128 g/mL), miconazole (0.256 g/mL) and itraconazole (0.256 g/mL). Specimens were stored in distilled water at 37 °C for 24 h, 7 days and 14 days prior to the hardness/roughness measurements...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28484255/the-antifungal-effects-and-mechanical-properties-of-silver-bromide-cationic-polymer-nano-composite-modified-poly-methyl-methacrylate-based-dental-resin
#19
Yu Zhang, Yin-Yan Chen, Li Huang, Zhi-Guo Chai, Li-Juan Shen, Yu-Hong Xiao
Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on Candida albicans ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and the mechanical properties of a silver bromide/cationic polymer nano-composite (AgBr/NPVP)-modified PMMA-based dental resin. AgBr/NPVP was added to the PMMA resin at 0.1, 0.2, and 0.3 wt%, and PMMA resin without AgBr/NPVP served as the control...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28476133/improving-practice-guidelines-for-the-treatment-of-denture-related-erythematous-stomatitis-a-study-protocol-for-a-randomized-controlled-trial
#20
Raphael F de Souza, Muhammad Faheem Khiyani, Carolina A L Chaves, Jocelyne Feine, Jean Barbeau, Ramón Fuentes, Eduardo Borie, Luciana C Crizostomo, Claudia H Silva-Lovato, Pierre Rompre, Elham Emami
BACKGROUND: Denture-related erythematous stomatitis (DES) is a chronic biofilm-mediated disease, affecting one in every three complete denture wearers. Antifungals are the treatment most commonly prescribed by oral health professionals, based on the belief that colonization by Candida spp. is the main cause of DES. However, high recurrence rates and adverse effects are commonly observed, prompting the need for practice guidelines regarding treatment. Results from our pilot study demonstrate that palatal brushing can reduce the palatal inflammation and potentially associated Candida carriage without any need for antifungal therapy...
May 5, 2017: Trials
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